EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.5.1.58 | Adenocarcinoma |
8090782 |
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
1
0 |
| 2.5.1.58 | Adenocarcinoma of Lung |
9252680 |
Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin. |
ongoing research
unassigned |
4
0 |
| 2.5.1.58 | Bone Diseases |
27400896 |
Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
1
2
0 |
| 2.5.1.58 | Bone Diseases |
29342131 |
Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib. |
causal interaction
therapeutic application
unassigned |
3
2
0 |
| 2.5.1.58 | Breast Neoplasms |
11705875 |
Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer. |
ongoing research
therapeutic application
unassigned |
4
2
0 |
| 2.5.1.58 | Breast Neoplasms |
12088116 |
The use of molecular markers in farnesyltransferase inhibitor (FTI) therapy of breast cancer. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
3
4
0 |
| 2.5.1.58 | Breast Neoplasms |
17415788 |
Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest. |
ongoing research
therapeutic application
unassigned |
4
3
0 |
| 2.5.1.58 | Carcinogenesis |
11822869 |
Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras. |
diagnostic usage
unassigned |
3
0 |
| 2.5.1.58 | Carcinogenesis |
15451670 |
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. |
unassigned |
0 |
| 2.5.1.58 | Carcinogenesis |
18713740 |
Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate. |
causal interaction
unassigned |
2
0 |
