EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.24.16 | neurolysin |
astrocyte |
contain only soluble enzyme |
37076 |
3.4.24.16 | neurolysin |
astrocyte |
- |
37080, 37082 |
2.6.1.64 | glutamine-phenylpyruvate transaminase |
astrocyte |
- |
288890 |
3.5.1.3 | omega-amidase |
astrocyte |
omega-amidase activity is about the same in cultured chick astrocytes and neurons |
288890 |
3.5.1.3 | omega-amidase |
astrocyte |
omega-amidase activity is higher in astrocytes than in neurons |
288890 |
3.5.1.3 | omega-amidase |
astrocyte |
omega-amidase activity is significantly higher in astrocytes than in neurons |
288890 |
3.5.1.3 | omega-amidase |
astrocyte |
primary cultures of astrocytes |
288890 |
1.8.5.1 | glutathione dehydrogenase (ascorbate) |
astrocyte |
perivascular |
394026 |
1.13.11.6 | 3-hydroxyanthranilate 3,4-dioxygenase |
astrocyte |
- |
439372, 439373 |
1.14.13.8 | flavin-containing monooxygenase |
astrocyte |
prepared from forebrain of 1-day old Swiss Webster mice |
440389 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
astrocyte |
low activity |
485498 |
2.7.10.1 | receptor protein-tyrosine kinase |
astrocyte |
- |
490550 |
3.4.24.82 | ADAMTS-4 endopeptidase |
astrocyte |
cell culture, expression of aggrecanase-1 mRNA is induced if cells are treated with beta-amyloid |
638959 |
3.4.24.86 | ADAM 17 endopeptidase |
astrocyte |
- |
639002 |
2.6.1.42 | branched-chain-amino-acid transaminase |
astrocyte |
- |
640019, 640025 |
2.7.1.1 | hexokinase |
astrocyte |
cerebrocortical astrocytes in primary culture, prepared from the neopallium |
640248 |
2.7.1.1 | hexokinase |
astrocyte |
hexokinase I: predominant in normal brain, hexokinase II: increased in brain tumors, ethylnitrosourea-induced 36B-10 astrocytic F-344 rat brain tumor cell line |
640259 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
astrocyte |
cerebral cortex astrocytes, isoform B |
640758 |
2.7.1.127 | inositol-trisphosphate 3-kinase |
astrocyte |
highest expression of recombinant isoenzyme A in astrocytes of hippocampal cultures transfected with isoenzyme A |
640760 |
1.21.99.3 | thyroxine 5-deiodinase |
astrocyte |
cell culture |
644801 |
1.21.99.3 | thyroxine 5-deiodinase |
astrocyte |
isozyme type III |
644801 |
6.3.2.2 | glutamate-cysteine ligase |
astrocyte |
primary cell culture |
649315 |
3.1.3.9 | glucose-6-phosphatase |
astrocyte |
low enzyme activities |
649729 |
4.3.2.1 | argininosuccinate lyase |
astrocyte |
- |
650743 |
3.1.3.67 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
astrocyte |
primary astrocyte, expression of wild-type enzyme |
650911 |
3.1.4.35 | 3',5'-cyclic-GMP phosphodiesterase |
astrocyte |
- |
652975 |
3.1.1.4 | phospholipase A2 |
astrocyte |
- |
653367 |
3.1.4.11 | phosphoinositide phospholipase C |
astrocyte |
adult brain, PLC-delta1 is concentrated in astroglial cells, much lower levels in neurons |
653442 |
1.1.1.42 | isocitrate dehydrogenase (NADP+) |
astrocyte |
- |
656588 |
1.4.1.3 | glutamate dehydrogenase [NAD(P)+] |
astrocyte |
predominantly |
656871 |
1.13.11.52 | indoleamine 2,3-dioxygenase |
astrocyte |
- |
657493, 743358 |
1.14.14.16 | steroid 21-monooxygenase |
astrocyte |
cultured cell |
658359 |
1.14.14.25 | cholesterol 24-hydroxylase |
astrocyte |
in normal brain |
659374 |
1.8.1.7 | glutathione-disulfide reductase |
astrocyte |
- |
-, 659860, 686856 |
2.7.11.13 | protein kinase C |
astrocyte |
primary, cortical |
661460 |
3.3.2.9 | microsomal epoxide hydrolase |
astrocyte |
patchy distribution |
661658 |
2.4.1.214 | glycoprotein 3-alpha-L-fucosyltransferase |
astrocyte |
- |
661837 |
5.3.99.2 | Prostaglandin-D synthase |
astrocyte |
lipocalin-type prostaglandin D synthase (beta-trace) is upregulated in the alphaB-crystallin-positive astrocytes in the chronic multiple sclerosis |
662954 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
astrocyte |
primary culture |
664476 |
3.4.22.61 | caspase-8 |
astrocyte |
no change in activity after irradiation |
664508 |
4.2.1.22 | cystathionine beta-synthase |
astrocyte |
cystathionine beta-synthase is associated with the generation and/or differentiation of the radial glia/astrocyte lineage cells in the developing central nervous system |
664879 |
3.4.11.2 | membrane alanyl aminopeptidase |
astrocyte |
- |
665112 |
3.5.3.15 | protein-arginine deiminase |
astrocyte |
pressure-treated astrocytes exhibit elevated PAD2 and citrullination without apparent change in PAD2 mRNA |
665252 |
3.1.3.9 | glucose-6-phosphatase |
astrocyte |
primary |
665603 |
3.1.1.23 | acylglycerol lipase |
astrocyte |
primary |
666129 |
3.5.3.15 | protein-arginine deiminase |
astrocyte |
- |
663848, 666136, 697491 |
3.2.1.143 | poly(ADP-ribose) glycohydrolase |
astrocyte |
cell culture |
666771 |
3.4.21.B7 | mannan-binding lectin-associated serine protease 1 |
astrocyte |
- |
666927 |
3.4.17.23 | angiotensin-converting enzyme 2 |
astrocyte |
transcriptional regulation of ACE2 mRNA in astrocytes is dependent on the relative concentrations of both angiotensin II and angiotensin(17) as well as on interaction with their respective receptors |
-, 667146 |
3.4.24.82 | ADAMTS-4 endopeptidase |
astrocyte |
- |
668117 |
3.4.24.B11 | ADAMTS1 endopeptidase |
astrocyte |
- |
668117 |
1.1.1.213 | 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific) |
astrocyte |
high expression and activity in astrocytes of glaucomatous optic nerve head |
668392 |
3.4.17.10 | carboxypeptidase E |
astrocyte |
cell culture |
669606 |
3.4.23.46 | memapsin 2 |
astrocyte |
astrocytic BACE1 expression may be important to the development of pathology in Alzheimer's disease |
669930 |
3.4.24.81 | ADAM10 endopeptidase |
astrocyte |
strain U373 MG |
669957 |
3.5.4.6 | AMP deaminase |
astrocyte |
similar level of expression of AMPD2, but greater expression of AMPD3 than in neurons |
669960 |
3.5.1.2 | glutaminase |
astrocyte |
phosphate-activated isozyme |
670129 |
3.4.24.35 | gelatinase B |
astrocyte |
enzyme expression is slightly induced by HIV and strongly induced by TNF alpha, while matrix metalloproteinase MMP-2 and tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 are only slightly affected. Astrocytes are a major source of enzyme in the inflamed brain |
670149 |
3.5.1.2 | glutaminase |
astrocyte |
isozymes LGA and KGA |
670391 |
7.2.2.9 | P-type Cu2+ transporter |
astrocyte |
- |
670415 |
2.6.1.7 | kynurenine-oxoglutarate transaminase |
astrocyte |
astrocytes in the substantia nigra express KAT-I under normal conditions. The amount of this enzyme increases after administration of 6-hydroxydopamine |
671174 |
2.4.1.1 | glycogen phosphorylase |
astrocyte |
expression of both muscle isoform and phosphorylase BB |
672848 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
astrocyte |
- |
672916 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
astrocyte |
MGMT gene expression is substantially lower in knockout p53 astrocytes than in wild-type p53 astrocytes |
672916 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
astrocyte |
- |
672959 |
2.1.1.63 | methylated-DNA-[protein]-cysteine S-methyltransferase |
astrocyte |
level of AGT is much reduced in mice lacking p53 |
673219 |
1.1.1.35 | 3-hydroxyacyl-CoA dehydrogenase |
astrocyte |
activated, high level expression |
673340 |
1.3.1.24 | biliverdin reductase |
astrocyte |
- |
673797 |
1.6.5.2 | NAD(P)H dehydrogenase (quinone) |
astrocyte |
enzyme is highly upregulated in active and chronic multiple sclerosis lesions, particularly in hypertrophic astrocytes and myelin-laden macrophages |
673798 |
6.3.2.2 | glutamate-cysteine ligase |
astrocyte |
- |
673803 |
1.2.1.105 | 2-oxoglutarate dehydrogenase system |
astrocyte |
- |
673870, 758628 |
1.4.3.3 | D-amino-acid oxidase |
astrocyte |
- |
674360, 687746, 711720 |
2.5.1.16 | spermidine synthase |
astrocyte |
- |
675523 |
7.1.1.9 | cytochrome-c oxidase |
astrocyte |
cortical astrocyte. Differential, cell-type specific expression of enzyme subunit IV isoform 2 in cortical astrocytes and cerebellar neurons. Presence of subunit IV isoform 2 suppresses the sensitivity of enzyme to its allosteric regulator ATP and overrules the regulation by the cellular energy level. Pivotal role of enzyme as an oxygen sensor in brain |
675529 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
astrocyte |
primary culture. Proliferation induced by fibrillar beta-amyloid peptide Abeta1-40 is mediated both by microglial release of TNF-alpha and by production of hydrogen peroxide by enzyme |
675531 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
astrocyte |
- |
675554 |
2.3.1.50 | serine C-palmitoyltransferase |
astrocyte |
increased SPT enzyme activity in reactive astrocytes of the hippocampus at 2 weeks post-kainate injection |
675555 |
2.4.2.3 | uridine phosphorylase |
astrocyte |
primary |
676187 |
2.7.1.20 | adenosine kinase |
astrocyte |
expressed most strongly in astrocytes |
676193 |
3.1.3.74 | pyridoxal phosphatase |
astrocyte |
4-5 days after ischemia PLP-P expressed in glial components |
679694 |
4.1.1.17 | ornithine decarboxylase |
astrocyte |
primary cells |
680257 |
3.1.4.11 | phosphoinositide phospholipase C |
astrocyte |
PI-PLC delta3 |
681021 |
4.6.1.1 | adenylate cyclase |
astrocyte |
- |
681092 |
3.1.3.21 | glycerol-1-phosphatase |
astrocyte |
- |
681523 |
3.4.22.36 | caspase-1 |
astrocyte |
- |
681931 |
3.1.3.3 | phosphoserine phosphatase |
astrocyte |
- |
682867 |
3.4.18.1 | cathepsin X |
astrocyte |
- |
683448 |
3.3.2.10 | soluble epoxide hydrolase |
astrocyte |
scattered astrocyte |
683721 |
3.4.24.56 | insulysin |
astrocyte |
primary |
683801 |
3.4.24.35 | gelatinase B |
astrocyte |
secretion, induced by interleukin-1beta |
683874 |
3.4.24.71 | endothelin-converting enzyme 1 |
astrocyte |
- |
684002 |
3.5.3.15 | protein-arginine deiminase |
astrocyte |
cortical |
686367 |
1.21.99.4 | thyroxine 5'-deiodinase |
astrocyte |
cell culture |
686407 |
2.1.4.1 | glycine amidinotransferase |
astrocyte |
- |
686537 |
1.11.1.9 | glutathione peroxidase |
astrocyte |
- |
685439, 686868 |
2.7.1.20 | adenosine kinase |
astrocyte |
astrocyte-based ADK provides a critical link between astrogliosis and neuronal dysfunction in epilepsy |
687973 |
2.1.1.2 | guanidinoacetate N-methyltransferase |
astrocyte |
- |
688183 |
2.4.1.38 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase |
astrocyte |
primary |
688471 |
2.4.1.92 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase |
astrocyte |
- |
688514 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
astrocyte |
insulin-like growth factor-I, epidermal growth factor, and insulin markedly increase TG-2 expression and activity. This effect is reduced when glial cultures are primed with both dexamethasone and estradiol. The regulation of TG-2 in astrocytes is signal- and hormone dependent |
688551 |