EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
Caco-2 cell |
intestinal cell line Caco-2/subclone TC7 |
438232, 438238 |
1.13.11.63 | beta-carotene 15,15'-dioxygenase |
Caco-2 cell |
when TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence |
438232 |
1.14.15.18 | calcidiol 1-monooxygenase |
Caco-2 cell |
- |
440130, 672936, 712885 |
2.3.1.57 | diamine N-acetyltransferase |
Caco-2 cell |
colon cancer cells Caco-2 and HTC-116 |
487270 |
2.3.2.13 | protein-glutamine gamma-glutamyltransferase |
Caco-2 cell |
cell line derived from human colon carcinoma |
487859 |
2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase |
Caco-2 cell |
- |
488679, 686976 |
2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase |
Caco-2 cell |
enzymic activity correlates with the degree of enterocytic differentiation |
488682 |
2.4.1.102 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
638293 |
2.4.1.146 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
638293 |
3.4.11.16 | Xaa-Trp aminopeptidase |
Caco-2 cell |
- |
643873 |
3.4.11.16 | Xaa-Trp aminopeptidase |
Caco-2 cell |
expressed both in undifferentiated and differentiated cell lines |
643874 |
3.1.1.7 | acetylcholinesterase |
Caco-2 cell |
well-differentiated colonic adenocarcinoma cell line |
651202 |
3.4.21.B25 | PACE4 proprotein convertase |
Caco-2 cell |
PACE4-C, PACE4-CS and PACE4-C |
651231 |
3.1.2.22 | palmitoyl[protein] hydrolase |
Caco-2 cell |
exclusively localized to the basolateral side of the polarized cells |
651451 |
1.3.1.72 | DELTA24-sterol reductase |
Caco-2 cell |
intestinal mucosa cells |
654502 |
3.2.1.51 | alpha-L-fucosidase |
Caco-2 cell |
- |
655418 |
1.11.1.6 | catalase |
Caco-2 cell |
adrenocortical tumor cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms |
655696 |
1.11.1.6 | catalase |
Caco-2 cell |
colon tumor cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms |
655696 |
2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
658123 |
2.4.1.144 | beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
658123 |
2.4.1.145 | alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
high activity |
658123 |
2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase |
Caco-2 cell |
- |
658123 |
2.4.1.90 | N-acetyllactosamine synthase |
Caco-2 cell |
colon adenocarcinoma cell line |
658123 |
2.1.1.13 | methionine synthase |
Caco-2 cell |
adenocyrcinoma cell line |
658413 |
2.3.1.76 | retinol O-fatty-acyltransferase |
Caco-2 cell |
- |
658662 |
1.14.12.17 | nitric oxide dioxygenase |
Caco-2 cell |
- |
658796 |
1.6.2.4 | NADPH-hemoprotein reductase |
Caco-2 cell |
- |
658948 |
2.4.1.165 | N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase |
Caco-2 cell |
colon carcinoma cell |
659083 |
2.4.1.147 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase |
Caco-2 cell |
expression of the enzyme is markedly down-regulated in gastric and colorectal carcinomas |
660389 |
2.7.11.18 | myosin-light-chain kinase |
Caco-2 cell |
endothelial cell, 2 isozymes MLCK1 and MLCK2 |
662316 |
3.2.1.48 | sucrose alpha-glucosidase |
Caco-2 cell |
- |
663852, 664558, 666140, 677949, 702506, 715559 |
4.1.1.17 | ornithine decarboxylase |
Caco-2 cell |
colon adenocarcinoma cell, enzyme activity decreases upon addition of L-arginine or L-methionine to growth medium |
664189 |
3.1.4.12 | sphingomyelin phosphodiesterase |
Caco-2 cell |
- |
664500, 682477, 705457, 705473 |
3.1.4.12 | sphingomyelin phosphodiesterase |
Caco-2 cell |
no mutation identified |
664532 |
3.2.1.10 | oligo-1,6-glucosidase |
Caco-2 cell |
- |
666140, 677949, 702506 |
3.4.11.6 | aminopeptidase B |
Caco-2 cell |
colorectal adenocarcinoma cell line |
666799 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
Caco-2 cell |
colon epithelial cell line, isozyme HSD2 |
667152 |
1.1.1.21 | aldose reductase |
Caco-2 cell |
colon cancer cell line |
668165 |
3.4.14.6 | dipeptidyl-dipeptidase |
Caco-2 cell |
enzyme activity is promoted by integrin subunit alpha2 blockade but decreased after subunit alpha6 blockade. Proliferative blockade using mitomycin C or hydroxyurea prevent the effects of subunit alpha2 ligation on differentiation |
668200 |
7.6.2.2 | ABC-type xenobiotic transporter |
Caco-2 cell |
- |
668705, 688594, 689065, 711833, 711926, 711931, 713065, 720505, 748695, 749400 |
3.4.24.22 | stromelysin 2 |
Caco-2 cell |
induction of enzyme expression by TNF-alpha and EGF |
670882 |
3.4.24.23 | matrilysin |
Caco-2 cell |
induction of enzyme expression by TNF-alpha and interleukin IL-1beta |
670882 |
3.4.24.7 | interstitial collagenase |
Caco-2 cell |
MMP-1 is upregulated by TGF-beta, EGF and IL-1beta |
670882 |
2.5.1.57 | N-acylneuraminate-9-phosphate synthase |
Caco-2 cell |
- |
671800 |
2.3.1.57 | diamine N-acetyltransferase |
Caco-2 cell |
induction by aspirin and different non-steroidal anti-inflammatory drugs |
671847 |
3.4.21.106 | hepsin |
Caco-2 cell |
non-transmembrane isoform expressed at highest level among investigated cell lines, transmembrane isoform hardly detectable |
672315 |
2.3.1.20 | diacylglycerol O-acyltransferase |
Caco-2 cell |
- |
672340 |
2.3.1.22 | 2-acylglycerol O-acyltransferase |
Caco-2 cell |
- |
672340 |
2.3.1.76 | retinol O-fatty-acyltransferase |
Caco-2 cell |
colon cancer cell line |
672340 |
2.7.1.48 | uridine/cytidine kinase |
Caco-2 cell |
- |
673504 |
2.7.10.1 | receptor protein-tyrosine kinase |
Caco-2 cell |
- |
674071 |
6.3.2.2 | glutamate-cysteine ligase |
Caco-2 cell |
oligophosphopeptides derived from egg yolk phosvitin up-regulate gamma-glutamylcysteine synthetase and antioxidant enzymes against oxidative stress in Caco-2 cells |
674140 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
Caco-2 cell |
- |
675015 |
2.4.1.17 | glucuronosyltransferase |
Caco-2 cell |
low-level UGT1A5 expression |
675594 |
2.4.1.17 | glucuronosyltransferase |
Caco-2 cell |
- |
675803, 735649 |
2.3.3.10 | hydroxymethylglutaryl-CoA synthase |
Caco-2 cell |
enzyme is a direct target of c-Myc, which represses hydroxymethylglutaryl-CoA synthase transcriptional activity |
675910 |
3.4.21.B26 | proprotein convertase 5 |
Caco-2 cell |
- |
675967 |
2.8.2.14 | bile-salt sulfotransferase |
Caco-2 cell |
- |
676007 |
2.8.2.15 | steroid sulfotransferase |
Caco-2 cell |
- |
676007, 738552 |
2.7.11.13 | protein kinase C |
Caco-2 cell |
- |
676258 |
1.14.11.2 | procollagen-proline 4-dioxygenase |
Caco-2 cell |
- |
676834 |
1.14.15.18 | calcidiol 1-monooxygenase |
Caco-2 cell |
intestinal cell line, both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation |
677255 |
3.2.1.108 | lactase |
Caco-2 cell |
- |
679123 |
3.2.1.108 | lactase |
Caco-2 cell |
fully differentiated, intestinal enterocyte-like cells |
679123 |
3.2.1.62 | glycosylceramidase |
Caco-2 cell |
- |
679123 |
3.1.1.23 | acylglycerol lipase |
Caco-2 cell |
- |
680845 |
4.6.1.2 | guanylate cyclase |
Caco-2 cell |
- |
681867 |
3.4.21.6 | coagulation factor Xa |
Caco-2 cell |
- |
683235 |
3.4.13.9 | Xaa-Pro dipeptidase |
Caco-2 cell |
- |
683964 |
7.2.2.9 | P-type Cu2+ transporter |
Caco-2 cell |
model for the ATP7A trafficking in enterocytes |
684720 |
1.6.3.1 | NAD(P)H oxidase (H2O2-forming) |
Caco-2 cell |
- |
685016, 711166 |
1.1.1.21 | aldose reductase |
Caco-2 cell |
- |
685925, 722714 |
1.8.1.9 | thioredoxin-disulfide reductase |
Caco-2 cell |
- |
687225 |
1.17.4.1 | ribonucleoside-diphosphate reductase |
Caco-2 cell |
a colon adenocarcinoma cell line |
688283 |
2.6.1.13 | ornithine aminotransferase |
Caco-2 cell |
- |
688566 |
2.7.11.18 | myosin-light-chain kinase |
Caco-2 cell |
- |
689353, 709236, 709287, 760849, 761603 |
3.1.1.1 | carboxylesterase |
Caco-2 cell |
isozyme CE2 |
692036 |
2.7.8.27 | sphingomyelin synthase |
Caco-2 cell |
isozymes SMS1 and SMS2 |
692991 |
2.7.11.10 | IkappaB kinase |
Caco-2 cell |
- |
693131 |
7.2.2.13 | Na+/K+-exchanging ATPase |
Caco-2 cell |
CACO-2BBE cell |
695476 |
1.6.5.10 | NADPH dehydrogenase (quinone) |
Caco-2 cell |
- |
696015 |
3.4.14.5 | dipeptidyl-peptidase IV |
Caco-2 cell |
- |
681294, 681319, 696912, 697519, 699748, 701430 |
3.4.22.62 | caspase-9 |
Caco-2 cell |
- |
699289 |
7.6.2.1 | P-type phospholipid transporter |
Caco-2 cell |
- |
700292, 747188 |
2.3.1.67 | 1-alkylglycerophosphocholine O-acetyltransferase |
Caco-2 cell |
- |
702406 |
2.8.2.1 | aryl sulfotransferase |
Caco-2 cell |
- |
705075, 738482, 760663, 760970 |
4.3.2.9 | gamma-glutamylcyclotransferase |
Caco-2 cell |
- |
705761 |
1.13.11.33 | arachidonate 15-lipoxygenase |
Caco-2 cell |
- |
706877 |
3.4.21.109 | matriptase |
Caco-2 cell |
cells target latent matriptase to the basolateral plasma membrane where activation, inhibition, and secretion of matriptase take place. A proportion of matriptase-HAI-1 complexes, but not the latent matriptase, undergoes transcytosis to the apical plasma membrane for secretion |
707054 |
3.4.21.109 | matriptase |
Caco-2 cell |
latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney |
707054 |
3.4.21.61 | Kexin |
Caco-2 cell |
- |
707305 |
3.4.21.73 | u-Plasminogen activator |
Caco-2 cell |
- |
707901 |
3.2.1.117 | amygdalin beta-glucosidase |
Caco-2 cell |
TC7 clone |
708783 |
3.2.1.118 | prunasin beta-glucosidase |
Caco-2 cell |
TC7 clone |
708783 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
Caco-2 cell |
- |
710599 |
7.2.2.9 | P-type Cu2+ transporter |
Caco-2 cell |
- |
710815 |
1.1.1.B40 | 11beta-hydroxysteroid dehydrogenase (NAD+) |
Caco-2 cell |
- |
711694 |
3.4.22.15 | cathepsin L |
Caco-2 cell |
- |
712554, 752853 |
3.1.1.43 | alpha-amino-acid esterase |
Caco-2 cell |
- |
715846, 729021 |
6.3.4.10 | biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase |
Caco-2 cell |
- |
715999 |