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Literature summary for 1.1.1.B40 extracted from

  • Garbrecht, M.R.; Schmidt, T.J.; Krozowski, Z.S.; Snyder, J.M.
    11beta-Hydroxysteroid dehydrogenase type 2 and the regulation of surfactant protein A by dexamethasone metabolites (2006), Am. J. Physiol. Endocrinol. Metab., 290, E653-E660.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
carbenoxolone
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
x * 40000, isozyme HSD2, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NAD+ Homo sapiens inactivation of the biologically active glucocorticoid cortisone + NADH
-
r
additional information Homo sapiens enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozymes HSD1 and HSD2
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell colon epithelial cell line, isozyme HSD2 Homo sapiens
-
lung adult and fetal, isozymes HSD1 and HSD2 Homo sapiens
-
NCI-H441 cell lung epithelial cell line, isozymes HSD1 and HSD2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NAD+
-
Homo sapiens cortisone + NADH
-
r
cortisol + NAD+ inactivation of the biologically active glucocorticoid Homo sapiens cortisone + NADH
-
r
additional information enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
dimer or trimer x * 40000, isozyme HSD2, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NADH
-
Homo sapiens