EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.17.23 | angiotensin-converting enzyme 2 |
Caco-2 cell |
- |
764930 |
3.4.21.106 | hepsin |
Caco-2 cell |
non-transmembrane isoform expressed at highest level among investigated cell lines, transmembrane isoform hardly detectable |
672315 |
3.4.21.109 | matriptase |
Caco-2 cell |
- |
732088 |
3.4.21.109 | matriptase |
Caco-2 cell |
cells target latent matriptase to the basolateral plasma membrane where activation, inhibition, and secretion of matriptase take place. A proportion of matriptase-HAI-1 complexes, but not the latent matriptase, undergoes transcytosis to the apical plasma membrane for secretion |
707054 |
3.4.21.109 | matriptase |
Caco-2 cell |
latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney |
707054 |
3.4.21.117 | stratum corneum chymotryptic enzyme |
Caco-2 cell |
- |
710599 |
3.4.21.6 | coagulation factor Xa |
Caco-2 cell |
- |
683235 |
3.4.21.61 | Kexin |
Caco-2 cell |
- |
707305 |
3.4.21.73 | u-Plasminogen activator |
Caco-2 cell |
- |
707901 |
3.4.21.B25 | PACE4 proprotein convertase |
Caco-2 cell |
PACE4-C, PACE4-CS and PACE4-C |
651231 |
3.4.21.B26 | proprotein convertase 5 |
Caco-2 cell |
- |
675967 |
3.4.21.B41 | kallikrein 10 |
Caco-2 cell |
- |
718439 |
3.4.21.B6 | prostasin |
Caco-2 cell |
- |
732088 |
3.4.22.1 | cathepsin B |
Caco-2 cell |
- |
717228 |
3.4.22.15 | cathepsin L |
Caco-2 cell |
- |
712554, 752853 |
3.4.22.62 | caspase-9 |
Caco-2 cell |
- |
699289 |
3.4.24.22 | stromelysin 2 |
Caco-2 cell |
induction of enzyme expression by TNF-alpha and EGF |
670882 |
3.4.24.23 | matrilysin |
Caco-2 cell |
induction of enzyme expression by TNF-alpha and interleukin IL-1beta |
670882 |
3.4.24.35 | gelatinase B |
Caco-2 cell |
- |
717980 |
3.4.24.7 | interstitial collagenase |
Caco-2 cell |
MMP-1 is upregulated by TGF-beta, EGF and IL-1beta |
670882 |
3.4.24.B3 | matrix metalloproteinase-11 |
Caco-2 cell |
- |
718998 |
3.5.1.2 | glutaminase |
Caco-2 cell |
- |
735073 |
3.6.4.B10 | chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing) |
Caco-2 cell |
- |
757782 |
4.1.1.17 | ornithine decarboxylase |
Caco-2 cell |
colon adenocarcinoma cell, enzyme activity decreases upon addition of L-arginine or L-methionine to growth medium |
664189 |
4.1.2.4 | deoxyribose-phosphate aldolase |
Caco-2 cell |
high activity |
747165 |
4.3.2.9 | gamma-glutamylcyclotransferase |
Caco-2 cell |
- |
705761 |
4.6.1.2 | guanylate cyclase |
Caco-2 cell |
- |
681867 |
5.6.2.1 | DNA topoisomerase |
Caco-2 cell |
Caco-2 cells have eight copies of the hTOPI gene, they show twofold more hTopI protein, and twofold higher activity of hTopI compared to HT-29 cells, but similar camptothecin sensitivity |
728804 |
6.2.1.3 | long-chain-fatty-acid-CoA ligase |
Caco-2 cell |
- |
675015 |
6.3.2.2 | glutamate-cysteine ligase |
Caco-2 cell |
oligophosphopeptides derived from egg yolk phosvitin up-regulate gamma-glutamylcysteine synthetase and antioxidant enzymes against oxidative stress in Caco-2 cells |
674140 |
6.3.4.10 | biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase |
Caco-2 cell |
- |
715999 |
7.1.2.2 | H+-transporting two-sector ATPase |
Caco-2 cell |
- |
734201 |
7.2.2.13 | Na+/K+-exchanging ATPase |
Caco-2 cell |
- |
734675, 751973 |
7.2.2.13 | Na+/K+-exchanging ATPase |
Caco-2 cell |
CACO-2BBE cell |
695476 |
7.2.2.8 | P-type Cu+ transporter |
Caco-2 cell |
- |
751471 |
7.2.2.9 | P-type Cu2+ transporter |
Caco-2 cell |
- |
710815 |
7.2.2.9 | P-type Cu2+ transporter |
Caco-2 cell |
model for the ATP7A trafficking in enterocytes |
684720 |
7.6.2.1 | P-type phospholipid transporter |
Caco-2 cell |
- |
700292, 747188 |
7.6.2.2 | ABC-type xenobiotic transporter |
Caco-2 cell |
- |
668705, 688594, 689065, 711833, 711926, 711931, 713065, 720505, 748695, 749400 |
7.6.2.3 | ABC-type glutathione-S-conjugate transporter |
Caco-2 cell |
- |
746940 |