1.1.1.21 aldose reductase Caco-2 cell - 685925, 722714 1.1.1.21 aldose reductase Caco-2 cell colon cancer cell line 668165 1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+) Caco-2 cell - 711694 1.1.1.B40 11beta-hydroxysteroid dehydrogenase (NAD+) Caco-2 cell colon epithelial cell line, isozyme HSD2 667152 1.11.1.6 catalase Caco-2 cell adrenocortical tumor cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms 655696 1.11.1.6 catalase Caco-2 cell colon tumor cell, increased activity of catalase in tumor cells recombinantly overexpressing IGFBP-2 probably mediated through IGF-independent mechanisms 655696 1.13.11.33 arachidonate 15-lipoxygenase Caco-2 cell - 706877 1.13.11.63 beta-carotene 15,15'-dioxygenase Caco-2 cell intestinal cell line Caco-2/subclone TC7 438232, 438238 1.13.11.63 beta-carotene 15,15'-dioxygenase Caco-2 cell when TC7 cells are maintained in serum-free medium, activity is increased 8.2fold after 19 days of postconfluence 438232 1.14.11.2 procollagen-proline 4-dioxygenase Caco-2 cell - 676834 1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase Caco-2 cell - 745525 1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase Caco-2 cell - 745525 1.14.12.17 nitric oxide dioxygenase Caco-2 cell - 658796 1.14.15.18 calcidiol 1-monooxygenase Caco-2 cell - 440130, 672936, 712885 1.14.15.18 calcidiol 1-monooxygenase Caco-2 cell intestinal cell line, both butyrate and 1alpha-25(OH)2D3 stimulate differentiation of Caco-2 cells, while 25(OH)2D3 has no impact on cell differentiation 677255 1.15.1.1 superoxide dismutase Caco-2 cell - 745523 1.17.4.1 ribonucleoside-diphosphate reductase Caco-2 cell a colon adenocarcinoma cell line 688283 1.3.1.72 DELTA24-sterol reductase Caco-2 cell intestinal mucosa cells 654502 1.4.3.22 diamine oxidase Caco-2 cell - 765044 1.5.3.17 non-specific polyamine oxidase Caco-2 cell - 764224 1.6.2.4 NADPH-hemoprotein reductase Caco-2 cell - 658948 1.6.3.1 NAD(P)H oxidase (H2O2-forming) Caco-2 cell - 685016, 711166 1.6.5.10 NADPH dehydrogenase (quinone) Caco-2 cell - 696015 1.8.1.9 thioredoxin-disulfide reductase Caco-2 cell - 687225 1.8.3.4 methanethiol oxidase Caco-2 cell methanethiol oxidase activity is strongly enhanced in Caco-2 cells upon enterocyte differentiation, in parallel with increased SELENBP1 levels 765747 2.1.1.13 methionine synthase Caco-2 cell adenocyrcinoma cell line 658413 2.1.1.319 type I protein arginine methyltransferase Caco-2 cell - 756861 2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase Caco-2 cell - 759760 2.3.1.20 diacylglycerol O-acyltransferase Caco-2 cell - 672340 2.3.1.22 2-acylglycerol O-acyltransferase Caco-2 cell - 672340 2.3.1.291 sphingoid base N-palmitoyltransferase Caco-2 cell - 753514 2.3.1.57 diamine N-acetyltransferase Caco-2 cell colon cancer cells Caco-2 and HTC-116 487270 2.3.1.57 diamine N-acetyltransferase Caco-2 cell induction by aspirin and different non-steroidal anti-inflammatory drugs 671847 2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase Caco-2 cell - 702406 2.3.1.76 retinol O-fatty-acyltransferase Caco-2 cell - 658662 2.3.1.76 retinol O-fatty-acyltransferase Caco-2 cell colon cancer cell line 672340 2.3.2.13 protein-glutamine gamma-glutamyltransferase Caco-2 cell Caco-2 intestinal cancer cells express crosslinking-competent tTG on their surface 759712 2.3.2.13 protein-glutamine gamma-glutamyltransferase Caco-2 cell cell line derived from human colon carcinoma 487859 2.3.3.10 hydroxymethylglutaryl-CoA synthase Caco-2 cell enzyme is a direct target of c-Myc, which represses hydroxymethylglutaryl-CoA synthase transcriptional activity 675910 2.4.1.102 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase Caco-2 cell - 638293 2.4.1.143 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Caco-2 cell - 658123 2.4.1.144 beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Caco-2 cell - 658123 2.4.1.145 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Caco-2 cell high activity 658123 2.4.1.146 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase Caco-2 cell - 638293 2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase Caco-2 cell expression of the enzyme is markedly down-regulated in gastric and colorectal carcinomas 660389 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase Caco-2 cell - 658123 2.4.1.165 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase Caco-2 cell - 488679, 686976 2.4.1.165 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase Caco-2 cell colon carcinoma cell 659083 2.4.1.165 N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N-acetylgalactosaminyltransferase Caco-2 cell enzymic activity correlates with the degree of enterocytic differentiation 488682 2.4.1.17 glucuronosyltransferase Caco-2 cell - 675803, 735649 2.4.1.17 glucuronosyltransferase Caco-2 cell low-level UGT1A5 expression 675594 2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase Caco-2 cell - 736582 2.4.1.90 N-acetyllactosamine synthase Caco-2 cell colon adenocarcinoma cell line 658123 2.4.2.12 nicotinamide phosphoribosyltransferase Caco-2 cell - 760043 2.4.3.2 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3-sialyltransferase Caco-2 cell type 2 mRNA isoform, type 1 mRNA isoform is not detected 744211 2.5.1.57 N-acylneuraminate-9-phosphate synthase Caco-2 cell - 671800 2.6.1.13 ornithine aminotransferase Caco-2 cell - 688566 2.7.1.105 6-phosphofructo-2-kinase Caco-2 cell - 749587 2.7.1.127 inositol-trisphosphate 3-kinase Caco-2 cell - 762015 2.7.1.48 uridine/cytidine kinase Caco-2 cell - 673504 2.7.10.1 receptor protein-tyrosine kinase Caco-2 cell - 674071 2.7.11.10 IkappaB kinase Caco-2 cell - 693131 2.7.11.13 protein kinase C Caco-2 cell - 676258 2.7.11.18 myosin-light-chain kinase Caco-2 cell - 689353, 709236, 709287, 760849, 761603 2.7.11.18 myosin-light-chain kinase Caco-2 cell endothelial cell, 2 isozymes MLCK1 and MLCK2 662316 2.7.6.2 thiamine diphosphokinase Caco-2 cell - 762080 2.7.7.1 nicotinamide-nucleotide adenylyltransferase Caco-2 cell - 737971 2.7.8.27 sphingomyelin synthase Caco-2 cell isozymes SMS1 and SMS2 692991 2.8.2.1 aryl sulfotransferase Caco-2 cell - 705075, 738482, 760663, 760970 2.8.2.14 bile-salt sulfotransferase Caco-2 cell - 676007 2.8.2.15 steroid sulfotransferase Caco-2 cell - 676007, 738552 2.8.2.2 alcohol sulfotransferase Caco-2 cell - 738482 2.8.2.5 chondroitin 4-sulfotransferase Caco-2 cell - 760531 3.1.1.1 carboxylesterase Caco-2 cell - 729359, 749814 3.1.1.1 carboxylesterase Caco-2 cell isozyme CE2 692036 3.1.1.116 sn-1-specific diacylglycerol lipase Caco-2 cell - 761578 3.1.1.23 acylglycerol lipase Caco-2 cell - 680845 3.1.1.43 alpha-amino-acid esterase Caco-2 cell - 715846, 729021 3.1.1.7 acetylcholinesterase Caco-2 cell well-differentiated colonic adenocarcinoma cell line 651202 3.1.2.22 palmitoyl[protein] hydrolase Caco-2 cell exclusively localized to the basolateral side of the polarized cells 651451 3.1.3.46 fructose-2,6-bisphosphate 2-phosphatase Caco-2 cell - 749587 3.1.3.86 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Caco-2 cell - 751770 3.1.3.9 glucose-6-phosphatase Caco-2 cell - 751406 3.1.4.12 sphingomyelin phosphodiesterase Caco-2 cell - 664500, 682477, 705457, 705473 3.1.4.12 sphingomyelin phosphodiesterase Caco-2 cell no mutation identified 664532 3.1.6.4 N-acetylgalactosamine-6-sulfatase Caco-2 cell - 721758 3.2.1.10 oligo-1,6-glucosidase Caco-2 cell - 666140, 677949, 702506 3.2.1.108 lactase Caco-2 cell - 679123 3.2.1.108 lactase Caco-2 cell fully differentiated, intestinal enterocyte-like cells 679123 3.2.1.117 amygdalin beta-glucosidase Caco-2 cell TC7 clone 708783 3.2.1.118 prunasin beta-glucosidase Caco-2 cell TC7 clone 708783 3.2.1.48 sucrose alpha-glucosidase Caco-2 cell - 663852, 664558, 666140, 677949, 702506, 715559 3.2.1.51 alpha-L-fucosidase Caco-2 cell - 655418 3.2.1.62 glycosylceramidase Caco-2 cell - 679123 3.4.11.16 Xaa-Trp aminopeptidase Caco-2 cell - 643873 3.4.11.16 Xaa-Trp aminopeptidase Caco-2 cell expressed both in undifferentiated and differentiated cell lines 643874 3.4.11.6 aminopeptidase B Caco-2 cell colorectal adenocarcinoma cell line 666799 3.4.13.9 Xaa-Pro dipeptidase Caco-2 cell - 683964 3.4.14.5 dipeptidyl-peptidase IV Caco-2 cell - 681294, 681319, 696912, 697519, 699748, 701430 3.4.14.6 dipeptidyl-dipeptidase Caco-2 cell enzyme activity is promoted by integrin subunit alpha2 blockade but decreased after subunit alpha6 blockade. Proliferative blockade using mitomycin C or hydroxyurea prevent the effects of subunit alpha2 ligation on differentiation 668200 3.4.17.23 angiotensin-converting enzyme 2 Caco-2 cell - 764930 3.4.21.106 hepsin Caco-2 cell non-transmembrane isoform expressed at highest level among investigated cell lines, transmembrane isoform hardly detectable 672315 3.4.21.109 matriptase Caco-2 cell - 732088 3.4.21.109 matriptase Caco-2 cell cells target latent matriptase to the basolateral plasma membrane where activation, inhibition, and secretion of matriptase take place. A proportion of matriptase-HAI-1 complexes, but not the latent matriptase, undergoes transcytosis to the apical plasma membrane for secretion 707054 3.4.21.109 matriptase Caco-2 cell latent matriptase is localized at the basolateral surface of the ductal epithelial cells of prostate and kidney 707054 3.4.21.117 stratum corneum chymotryptic enzyme Caco-2 cell - 710599 3.4.21.6 coagulation factor Xa Caco-2 cell - 683235 3.4.21.61 Kexin Caco-2 cell - 707305 3.4.21.73 u-Plasminogen activator Caco-2 cell - 707901 3.4.21.B25 PACE4 proprotein convertase Caco-2 cell PACE4-C, PACE4-CS and PACE4-C 651231 3.4.21.B26 proprotein convertase 5 Caco-2 cell - 675967 3.4.21.B41 kallikrein 10 Caco-2 cell - 718439 3.4.21.B6 prostasin Caco-2 cell - 732088 3.4.22.1 cathepsin B Caco-2 cell - 717228 3.4.22.15 cathepsin L Caco-2 cell - 712554, 752853 3.4.22.62 caspase-9 Caco-2 cell - 699289 3.4.24.22 stromelysin 2 Caco-2 cell induction of enzyme expression by TNF-alpha and EGF 670882 3.4.24.23 matrilysin Caco-2 cell induction of enzyme expression by TNF-alpha and interleukin IL-1beta 670882 3.4.24.35 gelatinase B Caco-2 cell - 717980 3.4.24.7 interstitial collagenase Caco-2 cell MMP-1 is upregulated by TGF-beta, EGF and IL-1beta 670882 3.4.24.B3 matrix metalloproteinase-11 Caco-2 cell - 718998 3.5.1.2 glutaminase Caco-2 cell - 735073 3.6.4.B10 chaperonin ATPase (protein-folding, protecting from aggregation, protein stabilizing) Caco-2 cell - 757782 4.1.1.17 ornithine decarboxylase Caco-2 cell colon adenocarcinoma cell, enzyme activity decreases upon addition of L-arginine or L-methionine to growth medium 664189 4.1.2.4 deoxyribose-phosphate aldolase Caco-2 cell high activity 747165 4.3.2.9 gamma-glutamylcyclotransferase Caco-2 cell - 705761 4.6.1.2 guanylate cyclase Caco-2 cell - 681867 5.6.2.1 DNA topoisomerase Caco-2 cell Caco-2 cells have eight copies of the hTOPI gene, they show twofold more hTopI protein, and twofold higher activity of hTopI compared to HT-29 cells, but similar camptothecin sensitivity 728804 6.2.1.3 long-chain-fatty-acid-CoA ligase Caco-2 cell - 675015 6.3.2.2 glutamate-cysteine ligase Caco-2 cell oligophosphopeptides derived from egg yolk phosvitin up-regulate gamma-glutamylcysteine synthetase and antioxidant enzymes against oxidative stress in Caco-2 cells 674140 6.3.4.10 biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase Caco-2 cell - 715999 7.1.2.2 H+-transporting two-sector ATPase Caco-2 cell - 734201 7.2.2.13 Na+/K+-exchanging ATPase Caco-2 cell - 734675, 751973 7.2.2.13 Na+/K+-exchanging ATPase Caco-2 cell CACO-2BBE cell 695476 7.2.2.8 P-type Cu+ transporter Caco-2 cell - 751471 7.2.2.9 P-type Cu2+ transporter Caco-2 cell - 710815 7.2.2.9 P-type Cu2+ transporter Caco-2 cell model for the ATP7A trafficking in enterocytes 684720 7.6.2.1 P-type phospholipid transporter Caco-2 cell - 700292, 747188 7.6.2.2 ABC-type xenobiotic transporter Caco-2 cell - 668705, 688594, 689065, 711833, 711926, 711931, 713065, 720505, 748695, 749400 7.6.2.3 ABC-type glutathione-S-conjugate transporter Caco-2 cell - 746940