EC Number   |
General Information |
Reference |
|---|
    1.4.3.1 | metabolism |
H2O2 is essential for the iodination of the tyrosyl residues to produce mono- and diiodotyrosine that are the precursors for the synthesis of thyroid hormones T3 and T4. interaction of endogenous D-Asp, D-AspO, and D-aspartate racemase in thyroid gland constitutes an additional biochemical pathway for the production of H2O2 and consequently for the synthesis of thyroid hormones, overview |
711722 |
| 1.4.3.1 | metabolism |
in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration, exaggerated D-Asp concentrations activate SOD1 as cytoprotective mechanism in the kidney, whereas, in the brain and in the heart, where the antioxidant action of SOD1 is limited, caspase 3 is activated, overview |
711721 |
| 1.4.3.1 | metabolism |
the reductive half-reaction is reversible. The kinetic mechanism follows a ternary complex mechanism characterized by a very fast step of flavin reduction followed by a rate-limiting reoxidation step |
763008 |
| 1.4.3.1 | more |
melatonin secretion and D-Asp release from pinealocytes are enhanced by stimulation with noradrenaline, after which the melatonin secretion is suppressed by the action of the released D-Asp on the cells. Through this negative feedback mechanism, noradrenaline may regulate its ability to induce melatonin secretion in the pineal gland |
711719 |
| 1.4.3.1 | physiological function |
age-related changes in D-aspartate oxidase promoter methylation control extracellular D-aspartate levels and prevent precocious cell death during brain aging. The enzyme expression is critical to regulate the content of the N-methyl-D-aspartate receptor agonist D-aspartate in adulthood |
743133 |
| 1.4.3.1 | physiological function |
D-Asp is important in the development and neurogenesis of the brain. D-Asp plays a regulatory role in the synthesis and secretion of prolactin in the anterior lobe of the pituitary gland. D-Asp directly interacts with DNA and/or acts on nuclear protein(s) involved in the regulation of gene transcription, through which d-Asp controls gene expression in the hypothalamo-neurohypophyseal system |
711719 |
| 1.4.3.1 | physiological function |
D-Asp oxidase is a FAD-containing flavoprotein that catalyzes the oxidative deamination of D-amino acids with O2 to generate the corresponding 2-oxo acids, along with H2O2 and NH3. DDO is highly specific for acidic D-amino acids, such as D-Asp, N-methyl-D-Asp, and D-Glu |
711718 |
| 1.4.3.1 | physiological function |
D-AspO plays an essential role in decreasing excessive amounts of D-Asp in frog tissues |
712616 |
| 1.4.3.1 | physiological function |
in frog tissue, D-AspO plays an essential role in modulating the D-Asp concentration. Induction of oxidative stress following D-Asp exposure is primarily related to its metabolism by inducible D-AspO |
711721 |
| 1.4.3.1 | physiological function |
relevance of D-Asp and DDO to NMDA receptor-related disease, D-Asp protects against sensorimotor-gating deficits, which are observed in schizophrenic patients, overview. D-Asp is important in the development and neurogenesis of the brain |
711719 |
