EC Number   |
Posttranslational Modification |
Reference |
|---|
    1.1.1.42 | acetylation |
SIRT3 deacetylates isoform IDH2 |
762409 |
| 1.1.1.42 | glutathionylation |
Cys269 of IDPc is a target for S-glutathionylation, this modification is reversed by dithiothreitol as well as enzymatically by cytosolic glutaredoxin in the presence of glutathione. Glutathionylated IDPc is significantly less susceptible than native protein to peptide fragmentation by reactive oxygen species and proteolytic digestion. Glutathionylation may play a protective role in the degradation of protein through the structural alterations of IDPc. |
698059 |
| 1.1.1.42 | glutathionylation |
S-glutathionylation of Cys363 is involved in the inhibition of the cytosolic enzyme activity upon nitrosoglutathione treatments |
760361 |
| 1.1.1.42 | nitration |
the enzyme protein is a target of inhibitory nitric oxide-mediated posttranslational modification (nitration) |
762026 |
| 1.1.1.42 | phosphoprotein |
the enzyme is phosphorylated at Ser113 by Escherichia coli isocitrate dehydrogenase kinase/phosphatase |
760653 |
| 1.1.1.42 | phosphoprotein |
tyrosine phosphorylated enzyme shows a significantly lowered enzymatic activity |
760487 |
| 1.1.1.42 | S-nitrosylation |
- |
760361 |
| 1.1.1.42 | S-nitrosylation |
the enzyme protein is a target of inhibitory H2S-mediated posttranslational modification (S-nitrosylation) |
762026 |
