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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58analysis procedure for labeling designed ankyrin repeat proteins (DARPins) engineered with a C-terminal CVIA sequence using an azide-containing FPP analog by yeast PFTase and procedures to subsequently conjugate the labeled DARPins to a TAMRA fluorophore 759730
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58drug development the enzyme from Aspergillus fumigatus is a target for antifungal drug design 739602
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine - 637511, 637514, 637515, 637516, 637517, 637525
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine analysis of reaction mechanism using catalytically active crystals and comparison with the human enzyme. In the CAAX binding site, a single residue substitution at the a2 site from tyrosine to asparagine results in a deeper cavity in this region compared with the human enzyme. The prenylated product exit groove is wider in the Cryptococcus neoformans enzyme relative to human enzyme and varies in amino acid composition. A substrate-induced conformational change observed for the 4alpha-5alpha loop of results in a molecular surface in the active site with two distinct states that can be individually exploited for inhibitor design -, 722725
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine design of a protein farnesyltransferase-driven plasma membrane-targeted chimeric peptide, PpIX-C6-PEG8-KKKKKKSKTKC-OMe, for plasma membrane-targeted photodynamic therapy and enhanced immunotherapy. The plasma membrane targeting ability of the peptide originates from the cellular K-Ras signaling, which occurs exclusively to drive the corresponding proteins to plasma membrane by protein farnesyltransferase 758576
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine enzyme a target in developing drug therapy for malaria 637524
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine enzyme from trypanosomatid parasites are target of anti-trypanosomatid agents because inhibitors of this enzyme are highly toxic to these parasites compared to mammalian cells -, 637511
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine evidence that inhibitors of enzyme could be effective therapeutic agents in treatment of many human cancers 636537, 637501, 637502, 637503, 637505, 637507, 637512, 637513, 637523
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine farnesyltransferase inhibitors as potential cancer therapeutics 705172
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.58medicine inhibition of protein farnesyltransferase with influence for oncogenesis, potential target for treatment of cancer 705065
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