Application | Comment | Organism |
---|---|---|
medicine | evidence that inhibitors of enzyme could be effective therapeutic agents in treatment of many human cancers | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Saccharomyces cerevisiae | |
Zn2+ | required | Saccharomyces cerevisiae |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
alpha,beta, 1 * 48000 + 1 * 46000 | Saccharomyces cerevisiae |
48000 | - |
alpha,beta, 1 * 48000 + 1 * 46000 | Saccharomyces cerevisiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | Saccharomyces cerevisiae | - |
S-farnesyl protein + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate | kinetic mechanism | Saccharomyces cerevisiae | |
farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate | enzyme constitutes the protein prenyltransferase family of enzymes | Saccharomyces cerevisiae | |
farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate | farnesyl diphosphate binds the enzyme in a two step process that may involve an enzyme conformational change, the enzyme-substrate complex then rapidly reacts with the peptide substrate to form a product, and product release is the rate-limiting step in catalysis | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F | Saccharomyces cerevisiae | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | - |
Saccharomyces cerevisiae | S-farnesyl protein + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | alpha,beta, 1 * 48000 + 1 * 46000 | Saccharomyces cerevisiae |