EC Number   |
Application |
Reference |
|---|
   1.1.1.B40 | drug development |
the enzyme is a target for inhibitor design and development |
669907 |
| 1.1.1.B40 | medicine |
11beta-HSD1 is a drug target for treatment of insulin resistance, diabetes and cardiovascular disease |
700178 |
| 1.1.1.B40 | medicine |
age-related reduced 11beta-HSD2 activity contributes to the rising prevalence of arterial hypertension in elderly |
695443 |
| 1.1.1.B40 | medicine |
at baseline, mRNA levels are similar in skeletal muscle of diabetic and control sugjects for 11beta-HSD1, 11beta-HSD2, and hexose-6-phosphate dehydrogenase. 11beta-HSD1 activity is reduced in diabetic subjects, while 11beta-HSD2 activity is increased. After application of dexamethasone, 11beta-HSD1 mRNA increases in both groups, whereas 11beta-HSD2 mRNA decreases. 11beta-HSD1 activity increases in diabetic subjects, but not in controls, whereas 11beta-HSD2 activity does not change in either group; mRNA levels are similar in diabetic and control subjects for 11beta-hydroxysteroid dehydrogenase 1 and 11beta-hydroxysteroid dehydrogenase 2. 11beta-Hydroxysteroid dehydrogenase 2-activity is higher in diabetic patients. After treatment with dexamethasone, 11beta-hydroxysteroid dehydrogenase 1-mRNA increases in both groups, whereas 11beta-hydroxysteroid dehydrogenase 2-mRNA decreases. 11beta-Hydroxysteroid dehydrogenase 1-activity increases in diabetic patients, but not in control, whereas 11beta-hydroxysteroid dehydrogenase 2-activity does not change in either group |
687961 |
| 1.1.1.B40 | medicine |
exposure of fetus to high levels of synthetic glucocorticoid may have long-lasting effects on the hippocampal expression of hypothalamic-pituitary-adrenal-related genes into adulthood |
688010 |
| 1.1.1.B40 | medicine |
high-fat fed animals overexpress 11beta-hydroxysteroid dehydrogenase type 2 in subcutaneous but not in retroperitoneal fat. Enzyme mRNA levels strongly correlate in both tissues with different parameters related to obesity, such as body weight, adiposity, and insulin resistance |
693880 |
| 1.1.1.B40 | medicine |
squirrel monkeys protect the mineralocorticoid receptor from activation by high cortisol levels in the kidney via upregulation of 11beta-HSD2 activity through increased production of the enzyme |
686234 |
| 1.1.1.B40 | medicine |
treatment of rats with dehydroepiandrosterone induces a shift from isoform 11beta-HSD1 to 11beta-HSD2 expression, increasing conversion from active to inactive glucocorticoids |
687317 |
| 1.1.1.B40 | pharmacology |
the enzyme is an important therapeutic target for diabetes in humans |
667673 |
