Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-nitro-furan-2-carboxylic acid (3-dimethylamino-propyl)-amide | reversible uncompetitive inhibition regarding substrate trypanothione disulfide, IC50 value for Trypanooma cruzi growth inhibition 0.0019 microM, EC50 value for toxicity against HeLa cells 0.074 microM | Trypanosoma cruzi | |
5-nitrofuran-2-carboxylic acid benzylamide | reversible uncompetitive inhibition regarding substrate trypanothione disulfide, IC50 value for Trypanooma cruzi growth inhibition 0.0015 microM, EC50 value for toxicity against HeLa cells 0.123 microM | Trypanosoma cruzi | |
5-nitrofuran-2-carboxylic acid dibenzylamide | reversible uncompetitive inhibition regarding substrate trypanothione disulfide, IC50 value for Trypanooma cruzi growth inhibition 0.0001 microM, EC50 value for toxicity against HeLa cells 0.078 microM | Trypanosoma cruzi | |
nifurtimox | - |
Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | V5AJG2 | - |
- |
Trypanosoma cruzi Dm28c | V5AJG2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH + H+ | - |
Trypanosoma cruzi Dm28c | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TCDM_11669 | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.061 | - |
5-nitrofuran-2-carboxylic acid benzylamide | pH 7.5, 30°C | Trypanosoma cruzi | |
0.068 | - |
5-nitrofuran-2-carboxylic acid dibenzylamide | pH 7.5, 30°C | Trypanosoma cruzi | |
0.118 | - |
5-nitro-furan-2-carboxylic acid (3-dimethylamino-propyl)-amide | pH 7.5, 30°C | Trypanosoma cruzi | |
0.245 | - |
nifurtimox | pH 7.5, 30°C | Trypanosoma cruzi |