Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-chloroethoxy)diphenylmethane | - |
Trypanosoma brucei | |
1-((2-benzhydryloxy)ethyl)piperazine | - |
Trypanosoma brucei | |
1-(1-benzo[b]thiophen-2-yl-cyclohexyl)-piperidine | - |
Trypanosoma brucei | |
1-(2-(benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine | GBR-12935 | Trypanosoma brucei | |
1-(3-phenylpropyl)piperazine | - |
Trypanosoma brucei | |
1-propylbenzene | - |
Trypanosoma brucei | |
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(3-phenyl-propyl)piperazine | - |
Trypanosoma brucei | |
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(E)-(3-phenyl-allyl)piperazine | - |
Trypanosoma brucei | |
1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-piperazine | - |
Trypanosoma brucei | |
2-chloro-10-(3-(4-(3-phenylpropyl)piperazin-1-yl)propyl)-10H-phenothiazine | - |
Trypanosoma brucei | |
3-Phenylpropylamine | - |
Trypanosoma brucei | |
4-chloromercuribenzoic acid | - |
Trypanosoma brucei | |
5-(2-chloroethoxy)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene | - |
Trypanosoma brucei | |
Bay 11-7085 | - |
Trypanosoma brucei | |
bromoacetyl alprenolol menthane | - |
Trypanosoma brucei | |
chlorpromazoine | - |
Trypanosoma brucei | |
clomipramine | - |
Trypanosoma brucei | |
ebselen | - |
Trypanosoma brucei | |
indatraline | - |
Trypanosoma brucei | |
perphenazine | - |
Trypanosoma brucei | |
pindobind | - |
Trypanosoma brucei | |
prochlorperazine | - |
Trypanosoma brucei | |
triflupromazine | - |
Trypanosoma brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma brucei | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
trypanothione reductase | - |
Trypanosoma brucei |
TryR | - |
Trypanosoma brucei |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma brucei | |
NADPH | - |
Trypanosoma brucei |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000251 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 4-chloromercuribenzoic acid | |
0.00075 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 2-chloro-10-(3-(4-(3-phenylpropyl)piperazin-1-yl)propyl)-10H-phenothiazine | |
0.00136 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | ebselen | |
0.00194 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(3-phenyl-propyl)piperazine | |
0.0021 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | bromoacetyl alprenolol menthane | |
0.00369 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-(1-benzo[b]thiophen-2-yl-cyclohexyl)-piperidine | |
0.0038 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | clomipramine | |
0.00488 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | perphenazine | |
0.00494 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | Bay 11-7085 | |
0.00632 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | chlorpromazoine | |
0.00689 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | pindobind | |
0.00726 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | indatraline | |
0.00746 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | prochlorperazine | |
0.00753 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | triflupromazine | |
0.0109 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-(2-(benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine | |
0.0269 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-4-(E)-(3-phenyl-allyl)piperazine | |
0.0297 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 5-(2-chloroethoxy)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene | |
0.0345 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-(3-phenylpropyl)piperazine | |
0.0487 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-((2-benzhydryloxy)ethyl)piperazine | |
0.0515 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-[2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yloxy)ethyl]-piperazine | |
0.0829 | - |
in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | (2-chloroethoxy)diphenylmethane | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 3-Phenylpropylamine | |
0.1 | - |
IC50 above 0.1 mM, in 40 mM HEPES pH 7.4, 1 mM EDTA, at 25°C | Trypanosoma brucei | 1-propylbenzene |