Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,5-bis(3,4,5-trimethoxyphenyl)furan | 3% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
2,5-bis(3,4-dimethoxyphenyl)furan | 7% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
2,5-bis(4-methoxyphenyl)furan | 15% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
2,5-bis(4-nitrophenyl)furan | 9% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
2,5-bis[4-(trifluoromethyl)phenyl]furan | 10% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
2,5-diphenylfuran | 4% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
2-(4-nitrophenyl)furan | 34% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine | IC50: 0.0065 mM | Trypanosoma cruzi | |
4,4'-furan-2,5-diyldibenzonitrile | 11% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
4-furan-2-ylbenzenesulfonamide | 8% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
4-furan-2-ylbenzonitrile | 5% inhibition at 0.02 mg/ml | Trypanosoma cruzi | |
N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide | IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Trypanosoma cruzi |
trypanothione reductase | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma cruzi |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0065 | - |
IC50: 0.0065 mM | Trypanosoma cruzi | 3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine | |
0.0485 | - |
IC50: 0.0485 mM, 54% inhibition at 0.02 mg/ml | Trypanosoma cruzi | N,N'-(furan-2,5-diyldibenzene-4,1-diyl)diacetamide |