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Disease on EC 2.3.1.74 - chalcone synthase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.
Clinicopathological and genomic comparisons between different histologic components in combined small cell lung cancer and non-small cell lung cancer.
Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma.
Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer.
Key genes in lung cancer translational research: a meta-analysis.
Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma.
Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells.
Adenocarcinoma of Lung
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas.
ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation.
ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.
ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.
EGFR mediates activation of RET in lung adenocarcinoma with neuroendocrine differentiation characterized by ASCL1 expression.
Adenoma
Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.
In situ validation of an intestinal stem cell signature in colorectal cancer.
Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression.
Astrocytoma
Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis.
Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma.
Autoimmune Diseases
Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease.
Brain Injuries
The Potential of Targeting Brain Pathology with Ascl1/Mash1.
Brain Injuries, Traumatic
Transplantation of human induced cerebellar granular-like cells improves motor functions in a novel mouse model of cerebellar ataxia.
Brain Neoplasms
ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models.
Breast Neoplasms
Elevated ASCL2 expression in breast cancer is associated with the poor prognosis of patients.
Involvement of Salicylic Acid on Antioxidant and Anticancer Properties, Anthocyanin Production and Chalcone Synthase Activity in Ginger (Zingiber officinale Roscoe) Varieties.
Carcinogenesis
Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.
ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.
Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer.
Co-expression of Achaete-Scute Homologue-1 and Calcitonin Gene-Related Peptide during NNK-Induced Pulmonary Neuroendocrine Hyperplasia and Carcinogenesis in Hamsters.
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice.
Distinct transcriptional programs of SOX2 in different types of small cell lung cancers.
Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.
Gene Manipulation with Micro RNAs at Single-Human Cancer Cell.
Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours.
Lack of nuclear expression of hairy and enhancer of split-1 (HES1) in pancreatic endocrine tumors.
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.
The Epithelial Sodium Channel (?ENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.
The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1.
Carcinoid Tumor
Chrysin suppresses achaete-scute complex-like 1 and alters the neuroendocrine phenotype of carcinoids.
Clinical-Pathologic Challenges in the Classification of Pulmonary Neuroendocrine Neoplasms and Targets on the Horizon for Future Clinical Practice.
Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis.
MG-132 Inhibits Carcinoid Growth and Alters the Neuroendocrine Phenotype.
Recent advances in histogenesis research of lung neuroendocrine cancers: Evidence obtained from functional analyses of primitive neural/neuroendocrine cell-specific transcription factors.
Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling.
Carcinoma
Achaete-scute complex homolog-1 promotes DNA repair in the lung carcinogenesis through matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.
Ascl1 represses the mesendoderm induction in Xenopus.
Ascl1-induced neuronal differentiation of P19 cells requires expression of a specific inhibitor protein of cyclic AMP-dependent protein kinase.
Detection of hypermethylated genes as markers for cervical screening in women living with HIV.
Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.
Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma.
Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis.
Key genes in lung cancer translational research: a meta-analysis.
NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas.
Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression.
Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells.
Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization.
SMYD3 controls a Wnt-responsive epigenetic switch for ASCL2 activation and cancer stem cell maintenance.
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and small cell lung cancer.
Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.
Carcinoma, Neuroendocrine
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Clinical-Pathologic Challenges in the Classification of Pulmonary Neuroendocrine Neoplasms and Targets on the Horizon for Future Clinical Practice.
Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells.
Carcinoma, Non-Small-Cell Lung
Detection and characterization of lung cancer using cell-free DNA fragmentomes.
Carcinoma, Squamous Cell
Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma.
Key genes in lung cancer translational research: a meta-analysis.
Cervical Intraepithelial Neoplasia
Detection of hypermethylated genes as markers for cervical screening in women living with HIV.
chalcone synthase deficiency
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development.
MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells.
Cholangiocarcinoma
Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours.
Colitis
Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease.
Colonic Neoplasms
Ascl2 activation by YAP1/KLF5 ensures the self-renewability of colon cancer progenitor cells.
Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells.
Downregulation of Ascl2 promotes cell apoptosis by enhancing autophagy in colorectal cancer cells.
MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): impact on the epithelial-mesenchymal transition in colon cancer cells.
R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells.
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
WiNTRLINC1/ASCL2/c-Myc Axis Characteristics of Colon Cancer with Differentiated Histology at Young Onset and Essential for Cell Viability.
Colorectal Neoplasms
Ascl2 and 11p15.5 amplification in colorectal cancer.
ASO Author Reflections: ASCL2, a Marker of Dynamic Colon Stem Cell, Involved in Wnt Pathway Activation Reflects Anti-cancer Drug Resistance in Primary Colorectal Cancer.
Comprehensive analysis of ?-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/?-catenin signaling.
Distribution of intestinal stem cell markers in colorectal precancerous lesions.
Downregulation of Ascl2 promotes cell apoptosis by enhancing autophagy in colorectal cancer cells.
Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer.
R-spondin1/Wnt-enhanced Ascl2 autoregulation controls the self-renewal of colorectal cancer progenitor cells.
SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.
Cushing Syndrome
Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome.
Cysts
Characterization of chitin synthases from Entamoeba.
Hypercyst mutants in Rhodospirillum centenum identify regulatory loci involved in cyst cell differentiation.
Demyelinating Diseases
Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination.
Endometrial Neoplasms
Discovery and validation of methylation markers for endometrial cancer.
Fetal Growth Retardation
Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
Glioblastoma
ASCL1 Promotes Differentiation of Glioblastoma Stem Cells.
ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.
Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
The Potential of Targeting Brain Pathology with Ascl1/Mash1.
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1.
Glioma
ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models.
Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
Inhibition of Glioma Development by ASCL1-Mediated Direct Neuronal Reprogramming.
Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis.
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and small cell lung cancer.
Hepatitis C
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Hirschsprung Disease
Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome).
Hyperventilation
Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome).
Infections
Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo.
Chalcone synthase as a reporter in virus-induced gene silencing studies of flower senescence.
Differential accumulation of plant defense gene transcripts in a compatible and an incompatible plant-pathogen interaction.
Induced responses to pathogen infection in Norway spruce phloem: changes in polyphenolic parenchyma cells, chalcone synthase transcript levels and peroxidase activity.
Involvement of kaempferol in the defence response of virus infected Arabidopsis thaliana
Lawsonia intracellularis exploits ?-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation.
Modulation of Arabidopsis Flavonol Biosynthesis Genes by Cyst and Root-Knot Nematodes.
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Neuronal transcription factors induce conversion of human glioma cells to neurons and inhibit tumorigenesis.
Transcriptomic Analysis of Resistant and Susceptible Responses in a New Model Root-Knot Nematode Infection System Using Solanum torvum and Meloidogyne arenaria.
Infertility, Male
Comprehensive transcriptome-based characterization of differentially expressed genes involved in microsporogenesis of radish CMS line and its maintainer.
Post-transcriptional silencing of flavonol synthase mRNA in tobacco leads to fruits with arrested seed set.
white anther: A petunia mutant that abolishes pollen flavonol accumulation, induces male sterility, and is complemented by a chalcone synthase transgene
Inflammatory Bowel Diseases
Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease.
Leukemia
TNF? activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation.
Leukemia, Lymphocytic, Chronic, B-Cell
Overexpression of the proneural transcription factor ASCL1 in chronic lymphocytic leukemia with a t(12;14)(q23.2;q32.3).
Lissencephaly
Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding.
Liver Diseases
Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy Pregnancy.
Lung Neoplasms
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.
Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702).
ASCL1 and RET expression defines a clinically relevant subgroup of lung adenocarcinoma characterized by neuroendocrine differentiation.
ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus.
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.
ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer.
Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer.
Co-expression of Achaete-Scute Homologue-1 and Calcitonin Gene-Related Peptide during NNK-Induced Pulmonary Neuroendocrine Hyperplasia and Carcinogenesis in Hamsters.
Detection and characterization of lung cancer using cell-free DNA fragmentomes.
Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors.
Key genes in lung cancer translational research: a meta-analysis.
NEUROD1 is highly expressed in extensive-disease small cell lung cancer and promotes tumor cell migration.
Polymorphism in ASCL1 target gene DDC is associated with clinical outcomes of small cell lung cancer patients.
POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer.
SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures.
Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression.
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and small cell lung cancer.
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
The Epithelial Sodium Channel (?ENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.
The prognostic implications of Notch1, Hes1, Ascl1, and DLL3 protein expression in SCLC patients receiving platinum-based chemotherapy.
Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma.
[Pathological and Molecular Biological Classification of Small Cell Lung Cancer].
Lymphatic Metastasis
Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer.
Elevated ASCL2 expression in breast cancer is associated with the poor prognosis of patients.
Lymphoma, B-Cell
Achaete-scute complex homologue 2 accelerates the development of Sjögren's syndrome-like disease in the NOD/ShiLtJ mouse.
Melanoma
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
Microcephaly
Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1.
Multiple Sclerosis
Ascl1/Mash1 promotes brain oligodendrogenesis during myelination and remyelination.
Mycoses
Rapid induction of phenylalanine ammonia-lyase and chalcone synthase mRNAs during fungus infection of soybean (Glycine max L.) roots or elicitor treatment of soybean cell cultures at the onset of phytoalexin synthesis.
Neoplasm Metastasis
ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMT.
Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer.
Elevated ASCL2 expression is associated with metastasis of osteosarcoma and predicts poor prognosis of the patients.
Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
Programmed Death Ligand 1 (PD-L1) Status and Tumor-Infiltrating Lymphocytes in Hot Spots of Primary and Liver Metastases in Prostate Cancer With Neuroendocrine Differentiation.
SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
Neoplasms
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Aberrant upregulation of ASCL2 by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells.
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.
Achaete-scute complex homologue 2 accelerates the development of Sjögren's syndrome-like disease in the NOD/ShiLtJ mouse.
Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia.
Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702).
ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.
ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers.
ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.
ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models.
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.
ASCL1-coexpression profiling but not single gene expression profiling defines lung adenocarcinomas of neuroendocrine nature with poor prognosis.
ASCL2 expression contributes to gastric tumor migration and invasion by downregulating miR223 and inducing EMT.
Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease.
Ascl2 Knockdown Results in Tumor Growth Arrest by miRNA-302b-Related Inhibition of Colon Cancer Progenitor Cells.
Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors.
Clinical and Biological Features of Neuroendocrine Prostate Cancer.
Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy.
Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma.
Detection of hypermethylated genes as markers for cervical screening in women living with HIV.
Distribution of LGR5+ cells and associated implications during the early stage of gastric tumorigenesis.
DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile.
Downregulation of Ascl2 promotes cell apoptosis by enhancing autophagy in colorectal cancer cells.
Elevated ASCL2 expression in breast cancer is associated with the poor prognosis of patients.
Elevated expression of ASCL2 is an independent prognostic indicator in lung squamous cell carcinoma.
Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice.
Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors.
Gene Manipulation with Micro RNAs at Single-Human Cancer Cell.
Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours.
Immunohistochemical study of the neural development transcription factors (TTF1, ASCL1 and BRN2) in neuroendocrine prostate tumours.
In situ validation of an intestinal stem cell signature in colorectal cancer.
Inhibition of phosphatidylinositol 3-kinase/Akt signaling suppresses tumor cell proliferation and neuroendocrine marker expression in GI carcinoid tumors.
Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors.
Lack of nuclear expression of hairy and enhancer of split-1 (HES1) in pancreatic endocrine tumors.
LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B.
Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients.
miR-375 is highly expressed and possibly transactivated by achaete-scute complex homolog 1 in small-cell lung cancer cells.
Molecular characterization of prostatic small-cell neuroendocrine carcinoma.
Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.
Molecular Subtypes of Primary Small Cell Lung Cancer Tumors and Their Associations with Neuroendocrine and Therapeutic Markers.
Nelfinavir Inhibits the Growth of Small-cell Lung Cancer Cells and Patient-derived Xenograft Tumors.
NEUROD1 is highly expressed in extensive-disease small cell lung cancer and promotes tumor cell migration.
Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro.
Norrin mediates opposing effects on tumor progression of glioblastoma stem cells.
Norrin mediates tumor-promoting and -suppressive effects in glioblastoma via Notch and WNT.
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities.
Pim1 kinase synergizes with c-MYC to induce advanced prostate carcinoma.
Potential Mechanism of Immune Evasion Associated with the Master Regulator ASCL2 in Microsatellite Stability in Colorectal Cancer.
POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.
RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis.
Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis.
SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
Shutdown of achaete-scute homolog-1 expression by heterogeneous nuclear ribonucleoprotein (hnRNP)-A2/B1 in hypoxia.
SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers.
SMYD3 controls a Wnt-responsive epigenetic switch for ASCL2 activation and cancer stem cell maintenance.
SNAIL1 combines competitive displacement of ASCL2 and epigenetic mechanisms to rapidly silence the EPHB3 tumor suppressor in colorectal cancer.
Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth.
Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal Neoplasia.
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and small cell lung cancer.
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
The Epithelial Sodium Channel (?ENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.
The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
The PARP inhibitor ABT-888 potentiates dacarbazine-induced cell death in carcinoids.
The Potential of Targeting Brain Pathology with Ascl1/Mash1.
The prognostic implications of Notch1, Hes1, Ascl1, and DLL3 protein expression in SCLC patients receiving platinum-based chemotherapy.
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1.
Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome.
[Prognostic Impact of Radiation Therapy and Molecular Classification of Infant Atypical Teratoid/Rhabdoid Tumors].
Neuroblastoma
ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry.
Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma.
Correction: Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma.
Dephosphorylation of the Proneural Transcription Factor ASCL1 Re-Engages a Latent Post-Mitotic Differentiation Program in Neuroblastoma.
PCP4/PEP19 downregulates neurite outgrowth via transcriptional regulation of Ascl1 and NeuroD1 expression in human neuroblastoma M17 cells.
Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.
Neuroendocrine Tumors
ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.
Genome-wide Analyses Identifies MEN1 and MAX Mutations and a Neuroendocrine-like Molecular Heterogeneity in Quadruple WT GIST.
Hypermethylation of adjacent CpG sites is negatively correlated with the expression of lineage oncogene ASCL1 in pulmonary neuroendocrine tumors.
Neuroendocrine phenotype alteration and growth suppression through apoptosis by MK-2206, an allosteric inhibitor of AKT, in carcinoid cell lines in vitro.
The Epithelial Sodium Channel (?ENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors.
Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid cancer cells.
Oligodendroglioma
Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2.
Osteosarcoma
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.
Elevated ASCL2 expression is associated with metastasis of osteosarcoma and predicts poor prognosis of the patients.
Papillomavirus Infections
HPV16-Related Cervical Cancers and Precancers Have Increased Levels of Host Cell DNA Methylation in Women Living with HIV.
Parkinson Disease
Embryonic development of selectively vulnerable neurons in Parkinson's disease.
Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease.
Pheochromocytoma
Inhibition of the PI3K Pathway Suppresses Hormonal Secretion and Limits Growth in Pheochromocytoma Cells.
Prostatic Neoplasms
Molecular characterization of prostatic small-cell neuroendocrine carcinoma.
Regulation of CEACAM5 and Therapeutic Efficacy of an Anti-CEACAM5-SN38 Antibody-drug Conjugate in Neuroendocrine Prostate Cancer.
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
Pulmonary Fibrosis
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/??catenin signaling activation (Review).
Rectal Neoplasms
Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.
Retinoblastoma
Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.
Rhabdomyosarcoma
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Sarcoma
Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.
Small Cell Lung Carcinoma
Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.
Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702).
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer.
Clinicopathological features and prognostic implications of ASCL1 expression in surgically resected small cell lung cancer.
Detection and characterization of lung cancer using cell-free DNA fragmentomes.
Key genes in lung cancer translational research: a meta-analysis.
NEUROD1 is highly expressed in extensive-disease small cell lung cancer and promotes tumor cell migration.
Polymorphism in ASCL1 target gene DDC is associated with clinical outcomes of small cell lung cancer patients.
POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer.
SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures.
Sensitivity of Small Cell Lung Cancer to BET Inhibition Is Mediated by Regulation of ASCL1 Gene Expression.
Significance of achaete-scute complex homologue 1 (ASCL1) in pulmonary neuroendocrine carcinomas; RNA sequence analyses using small cell lung cancer cells and Ascl1-induced pulmonary neuroendocrine carcinoma cells.
Small Cell Lung Carcinoma Subtypes Defined by ASCL1, NEUROD1, POU2F3 and YAP1: Comprehensive Immunohistochemical and Histopathologic Characterization.
System analysis identifies distinct and common functional networks governed by transcription factor ASCL1, in glioma and small cell lung cancer.
[Pathological and Molecular Biological Classification of Small Cell Lung Cancer].
Stomach Neoplasms
Aberrant upregulation of ASCL2 by promoter demethylation promotes the growth and resistance to 5-fluorouracil of gastric cancer cells.
Bufalin inhibits gastric cancer invasion and metastasis by down-regulating Wnt/ASCL2 expression.
Stroke
Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis.
The Potential of Targeting Brain Pathology with Ascl1/Mash1.
Thyroid Neoplasms
Overexpression of the NOTCH1 intracellular domain inhibits cell proliferation and alters the neuroendocrine phenotype of medullary thyroid cancer cells.
Uterine Cervical Neoplasms
Detection of hypermethylated genes as markers for cervical screening in women living with HIV.
Evaluation of six methylation markers derived from genome-wide screens for detection of cervical precancer and cancer.