Reference on EC 2.3.1.15 - glycerol-3-phosphate 1-O-acyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Weber, S.; Wolter, F.P.; Buck, F.; Frentzen, M.
Purification and cDNA sequencing of an oleate-selective acyl-ACP: sn-glycerol-3-phosphate acyltransferase from pea chloroplasts
Plant Mol. Biol.
17
1067-1076
1991
Pisum sativum
Bafor, M.; Stobart, A.K.; Stymne, S.
Properties of the glycerol acylating enzymes in microsomal preparations from the developing seeds of safflower (Carthamus tinctorius) and turnip rape (Brassica campestris) and their ability to assemble cocoa-butter type fats
J. Am. Oil Chem. Soc.
67
217-225
1990
Brassica rapa subsp. oleifera, Carthamus tinctorius
Hershenson, S.; Ernst-Fonberg, M.L.
Comparison of 1-acylglycerophosphate and glycerophosphate acyltransferases from Euglena microsomes
Int. J. Biochem.
16
219-223
1984
Euglena sp.
Bramley, P.M.; Grigor, M.R.
Acyl-CoA:sn-glycerol 3-phosphate acetyltransfrase isozymes in rat mammary gland
Biochem. Int.
5
199-204
1982
Rattus norvegicus
-
Frentzen, M.
Comparison of certain properties of membrane bound and solubilized acetyltransferase activities of plant microsomes
Plant Sci.
69
39-48
1990
Pisum sativum, Spinacia oleracea
-
Bell, R.M.; Coleman, R.A.
Enzymes of triacylglycerol formation in mammals
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
16
87-111
1983
Escherichia coli, Rattus norvegicus
-
Frentzen, M.; Heinz, E.; McKeon, T.A.; Stumpf, P.K.
Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts
Eur. J. Biochem.
129
629-636
1983
Pisum sativum, Spinacia oleracea
Bertrams, M.; Heinz, E.
Positional specificity and fatty acid selectivity of purified sn-glycerol 3-phosphate acyltransferases from chloroplasts
Plant Physiol.
68
653-657
1981
Pisum sativum, Spinacia oleracea
Frentzen, M.; Neuburger, M.; Joyard, J.; Douce, R.
Intraorganelle localization and substrate specificities of the mitochondrial acyl-CoA: sn-glycerol-3-phosphate O-acyltransferase and acyl-CoA: 1-acyl-sn-glycerol-3-phosphate O-acyltransferase from potato tubers and pea leaves
Eur. J. Biochem.
187
395-402
1990
Pisum sativum, Solanum tuberosum
Grobovsky, L.V.; Hershenson, S.; Ernst-Fonberg, M.L.
Isolation of sn-glycerol-3-phosphate acyltransferase from achloroplastic Euglena
FEBS Lett.
102
261-264
1979
Euglena gracilis
Fritz, P.K.; Kauffman, J.M.; Robertson, C.A.; Wilson, M.R.
Cocoa butter biosynthesis. Purification and characterization of a soluble sn-glycerol-3-phosphate acyltransferase from cocoa seeds
J. Biol. Chem.
261
194-199
1986
Theobroma cacao
Douady, D.; Dubacq, J.P.
Purification of acyl-CoA: glycerol-3-phosphate acyltransferas from pea leaves
Biochim. Biophys. Acta
921
615-619
1987
Pisum sativum
-
Zaror-Behrens, G.; Kako, K.J.
Positional and fatty acid specificity of monoacyl- and diacylglycerol 3-phosphate formation by rabbit heart microsomes
Biochim. Biophys. Acta
441
1-13
1976
Oryctolagus cuniculus
Hendry, A.T.; Possmayer, F.
Pulmonary phospholipid biosynthesis. Properties of a stable microsomal glycerophosphate acyltransferase preparation from rabbit lung
Biochim. Biophys. Acta
369
156-172
1974
Oryctolagus cuniculus
Kume, K.; Shimizu, T.; Seyama, Y.
Characterization of sn-glycerol 3-phosphate acyltransferase from guinea pig harderian gland microsomes
J. Biochem.
101
653-660
1987
Cavia porcellus
Haldar, D.; Vancura, A.
Glycerophosphate acyltransferase from liver
Methods Enzymol.
209
64-72
1992
Rattus norvegicus
Yamashita, S.; Numa, S.
Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A
Eur. J. Biochem.
31
565-573
1972
Rattus norvegicus, Rattus norvegicus Wistar
Bates, E.J.; Saggerson, E.D.
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment
Biochem. J.
182
751-762
1979
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Monroy, G.; Chroboczek Kelker, H.; Pullman, M.E.
Partial purification and properties of an acyl coenzyme A:sn-glycerol 3-phosphate acyltransferase from rat liver mitochondria
J. Biol. Chem.
248
2845-2852
1973
Rattus norvegicus
Carroll, M.A.; Morris, P.E.; Grosjean, C.D.; Anzalone, T.; Haldar, D.
Further distinguishing properties of mitochondrial and microsomal glycerophosphate acyltransferase and the transmembrane location of the mitochondrial enzyme
Arch. Biochem. Biophys.
214
17-25
1982
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Coleman, R.A.
Hepatic sn-glycerol-3-phosphate acyltransferases: effect of monoacylglycerol analogs on mitochondrial and microsomal activities
Biochim. Biophys. Acta
963
367-374
1988
Rattus norvegicus
Datta, N.S.; Hajra, A.K.
Does microsomal glycerophosphate acyltransferase also catalyze the acylation of dihydroxyacetone phosphate?
FEBS Lett.
176
264-268
1984
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Okuyama, H.; Yamada, K.; Kameyama, Y.; Ikezawa, H.; Fukushima, H.; Nozawa, Y.
Studies on lipid metabolism in Tetrahymena pyriformis: properties of acyltransferase systems
Arch. Biochem. Biophys.
178
319-326
1977
Tetrahymena pyriformis
Schlossman, D.M.; Bell, R.M.
Glycerolipid biosynthesis in Saccharomyces cerevisiae: sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities
J. Bacteriol.
133
1368-1376
1978
Saccharomyces cerevisiae
Green, P.R.; Merrill, A.H.; Bell, R.M.
Membrane phospholipid synthesis in Escherichia coli. Purification, reconstitution, and characterization of sn-glycerol-3-phosphate acyltransferase
J. Biol. Chem.
256
11151-11159
1981
Escherichia coli
Kessels, J.M.M.; Van Den Bosch, H.
Characterization of reconstituted partially purified glycerophosphate acyltansferase from Escherichia coli
Biochim. Biophys. Acta
713
570-580
1982
Escherichia coli
Scheideler, M.A.; Bell, R.M.
Characterization of active and latent forms of the membrane-associated sn-glycerol-3-phosphate acyltransferase of Escherichia coli
J. Biol. Chem.
266
14321-14327
1991
Escherichia coli
Scheideler, M.A.; Bell, R.M.
Efficiency of reconstitution of the membrane-associated sn-glycerol 3-phosphate acyltransferase of Escherichia coli
J. Biol. Chem.
261
10990-10995
1986
Escherichia coli
Kessels, J.M.M.; Ousen, H.; Van Den Bosch, H.
Studies on reconstituted partially purified glycerophosphate acyltransferase from Escherichia coli
Eur. J. Biochem.
138
543-549
1984
Escherichia coli
Kito, M.; Ishinaga, M.; Nishihara, M.
Function of phospholipids on the regulatory properties of solubilized and membrane-bound sn-glycerol-3-phosphate acyltransferase of Escherichia coli
Biochim. Biophys. Acta
529
237-249
1978
Escherichia coli, Escherichia coli B / ATCC 11303
Negrel, R.; Ailhaud, G.; Mutaftschiev, S.
Comparative inhibition studies of the phosphotransferase and glycerophosphate acylation systems in membrane vesicles of Escherichia coli
Biochim. Biophys. Acta
291
635-649
1973
Escherichia coli, Escherichia coli ML 308-225
Kito, M.; Aibara, S.; Hasegawa, K.; Hata, T.
Inhibition of L-glycerol 3-phosphate acyltransferase from Escherichia coli by cis-9,10-methylenehexadecanoic acid
J. Biochem.
71
99-105
1972
Escherichia coli, Escherichia coli B / ATCC 11303
Ishinaga, M.; Nishihara, M.; Kito, M.
Purification and positional specificity of sn-glycerol-3-phosphate acyltransferase from Escherichia coli membranes
Biochim. Biophys. Acta
450
269-272
1976
Escherichia coli, Escherichia coli B / ATCC 11303
Snider, M.D.; Kennedy, E.P.
Partial purification of glycerophosphate acyltransferase from Escherichia coli
J. Bacteriol.
130
1072-1083
1977
Escherichia coli, Escherichia coli 8
Snider, M.D.
sn-Glycero-3-phosphate acyltransferase from Escherichia coli
Methods Enzymol.
71
546-550
1981
Escherichia coli
Yamashita, S.; Numa, S.
Glycerophosphate acyltransferase from rat liver
Methods Enzymol.
71
550-554
1981
Rattus norvegicus, Rattus norvegicus Wistar
Marchand, C.; Lemonde, A.; Beaudoin, A.R.
Isolation and properties of a glycerophosphate acylating fraction in the fat body of Schistocerca gregaria (Forskal)
Can. J. Biochem.
55
1166-1170
1977
Schistocerca gregaria
Barron, E.J.; Stumpf, P.K.
Fat metabolism in higher plants. XIX. The biosynthesis of triglycerides by avocado-mesocarp enzymes
Biochim. Biophys. Acta
60
329-337
1962
Persea americana
Scheideler, M.A.; Bell, R.M.
Glycerophosphate acyltransferase from Escherichia coli
Methods Enzymol.
209
55-63
1992
Escherichia coli
Okuyama, H.; Wakil, S.J.
Positional specificities of acyl coenzyme A: glycerophosphate and acyl coenzyme A: monoacylglycerophosphate acyltransferases in Escherichia coli
J. Biol. Chem.
248
5197-5205
1973
Escherichia coli, Escherichia coli B / ATCC 11303
Okuyama, H.; Yamada, K.; Ikezawa, H.; Wakil, S.J.
Factors affecting the acyl selectivities of acyltransferases in Escherichia coli
J. Biol. Chem.
251
2487-2492
1976
Escherichia coli, Escherichia coli B / ATCC 11303
Yamada, K.; Okuyama, H.; Endo, Y.; Ikezawa, H.
Acyltransferase systems involved in phospholipid metabolism in Saccharomyces cerevisiae
Arch. Biochem. Biophys.
183
281-289
1977
Saccharomyces cerevisiae, Saccharomyces cerevisiae OC-2
Yet, S.F.; Lee, S.; Hahm, Y.T.; Sul, H.S.
Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase
Biochemistry
32
9486-9491
1993
Mus musculus
Mitchell, J.R.D.; Saggerson, E.D.
A study of glycerolphosphate acyltransferase in rat liver mitochondria - submitochondrial localization and some properties of the solubilized enzyme
Int. J. Biochem.
26
181-187
1994
Rattus norvegicus
Vancura, A.; Haldar, D.
Purification and characterization of glycerophosphate acyltransferase from rat liver mitochondria
J. Biol. Chem.
269
27209-27215
1994
Rattus norvegicus
Eccleston, V.S.; Harwood, J.L.
Solubilization, partial purification and properties of acyl-CoA:glycerol-3-phosphate acyltransferase from avocado (Persea americana) fruit mesocarp
Biochim. Biophys. Acta
1257
1-10
1995
Persea americana
Yet, S.F.; Moon, Y.K.; Sul, H.S.
Purification and reconstitution of murine mitochondrial glycerol-3-phosphate acyltransferase. Functional expression in baculovirus-infected insect cells
Biochemistry
34
7303-7310
1995
Mus musculus
Wilkison, W.O.; Bell, R.M.
sn-Glycerol-3-phosphate acyltransferase from Escherichia coli
Biochim. Biophys. Acta
1348
3-9
1997
Escherichia coli
Murata, N.; Tasaka, Y.
Glycerol-3-phosphate acyltransferase in plants
Biochim. Biophys. Acta
1348
10-16
1997
Arabidopsis thaliana, Persea americana, Ricinus communis, Cucumis sativus, Cucurbita moschata, Phaseolus vulgaris, Pisum sativum, Solanum tuberosum, Spinacia oleracea
Dircks, L.K.; Sul, H.S.
Mammalian mitochondrial glycerol-3-phosphate acyltransferase
Biochim. Biophys. Acta
1348
17-26
1997
Cavia porcellus, Mus musculus, Rattus norvegicus
Ferri, S.R.; Toguri, T.
Substrate specificity modification of the stromal glycerol-3-phosphate acyltransferase
Arch. Biochem. Biophys.
337
202-208
1997
Cucurbita moschata, Spinacia oleracea
Dircks, L.K.; Ke, J.; Sul, H.S.
A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity. Significance of arginine 318 in catalysis
J. Biol. Chem.
274
34728-34734
1999
Mus musculus (Q61586), Mus musculus
Ganesh Bhat, B.; Wang, P.; Kim, J.H.; Black, T.M.; Lewin, T.M.; Fiedorek, F.T., Jr.; Coleman, R.A.
Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein
Biochim. Biophys. Acta
1439
415-423
1999
Escherichia coli, Rattus norvegicus, Rattus norvegicus (P97564)
Slabas, A.R.; Simon, W.R.; Schierer, T.; Kroon, J.; Fawcett, T.; Hayman, M.; Gilroy, J.; Nishida, I.; Murata, N.; Rafferty, J.; Turnbull, A.; Rice, D.
Plant glycerol-3-phosphate-1-acyltransferase (GPAT): structure selectivity studies
Biochem. Soc. Trans.
28
677-679
2000
Arabidopsis thaliana, Cucurbita moschata, Elaeis guineensis, Pisum sativum, Spinacia oleracea
Hayman, M.W.; Fawcett, T.; Schierer, T.F.; Simon, J.W.; Kroon, J.T.M.; Gilroy, J.S.; Rice, D.W.; Rafferty, J.; Turnbull, A.P.; Sedelnikova, S.E.; Slabas, A.R.
Mutagenesis of squash (Cucurbita moschata) glycerol-3-phosphate acyltransferase (GPAT) to produce an enzyme with altered substrate selectivity
Biochem. Soc. Trans.
28
680-681
2000
Arabidopsis thaliana, Cucurbita moschata
Nishida, I.; Sugiura, M.; Enju, A.; Nakamura, M.
A second gene for acyl-(acyl-carrier-protein): glycerol-3-phosphate acyltransferase in squash, Cucurbita moschata cv. Shirogikuza(*), codes for an oleate-selective isozyme: molecular cloning and protein purification studies
Plant Cell Physiol.
41
1381-1391
2000
Cucurbita moschata (Q9FEP9), Cucurbita moschata (Q9FEQ0), Cucurbita moschata
Gonzalez-Baro, M.R.; Granger, D.A.; Coleman, R.A.
Mitochondrial glycerol phosphate acyltransferase contains two transmembrane domains with the active site in the N-terminal domain facing the cytosol
J. Biol. Chem.
276
43182-43188
2001
Rattus norvegicus
Zheng, Z.; Zou, J.
The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae
J. Biol. Chem.
276
41710-41716
2001
Saccharomyces cerevisiae (P32784), Saccharomyces cerevisiae (P36148), Saccharomyces cerevisiae
Mishra, S.; Kamisaka, Y.
Purification and characterization of thiol-reagent-sensitive glycerol-3-phosphate acyltransferase from the membrane fraction of an oleaginous fungus
Biochem. J.
355
315-322
2001
Umbelopsis ramanniana
Turnbull, A.P.; Rafferty, J.B.; Sedelnikova, S.E.; Slabas, A.R.; Schierer, T.P.; Kroon, J.T.M.; Simon, J.W.; Fawcett, T.; Nishida, I.; Murata, N.; Rice, D.W.
Analysis of the Structure, substrate specificity, and mechanism of squash slycerol-3-Phosphate (1)-acyltransferase
Structure
9
347-353
2001
Cucurbita moschata
Slabas, A.R.; Kroon, J.T.M.; Scheirer, T.P.; Gilroy, J.S.; Hayman, M.; Rice, D.W.; Turnbull, A.P.; Rafferty, J.B.; Fawcett, T.; Simon, W.J.
Squash Glycerol-3-phosphate (1)-Acyltransferase. Alteration of substrate selectivity and identification of arginine and lysine residues important in catalytic activity
J. Biol. Chem.
277
43918-43923
2002
Arabidopsis thaliana, Cucurbita moschata, Elaeis guineensis
Hayman, M.W.; Fawcett, T.; Slabas, A.R.
Kinetic mechanism and order of substrate binding for sn-glycerol-3-phosphate acyltransferase from squash (Cucurbita moschata)
FEBS Lett.
514
281-284
2002
Arabidopsis thaliana, Cucurbita moschata
Nishida, I.; Frentzen, M.; Ishizaki, O.; Murata, N.
Purification of isomeric forms of acyl-[acyl-carrier-protein]:glycerol-3-phosphate acyltransferase from greening squash cotyledons
Plant Cell Physiol.
28
1071-1079
1987
Cucurbita moschata, Escherichia coli
-
Tamada, T.; Feese, M.D.; Ferri, S.R.; Kato, Y.; Yajima, R.; Toguri, T.; Kuroki, R.
Substrate recognition and selectivity of plant glycerol-3-phosphate acyltransferases (GPATs) from Cucurbita moschata and Spinacia oleracea
Acta Crystallogr. Sect. D
60
13-21
2004
Cucurbita moschata, Spinacia oleracea
Lewin, T.M.; Wang, S.; Nagle, C.A.; Van Horn, C.G.; Coleman, R.A.
Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes
Am. J. Physiol.
288
E835-844
2005
Rattus norvegicus
Kannan, L.; Knudsen, J.; Jolly, C.A.
Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity
Biochim. Biophys. Acta
1631
12-16
2003
Rattus norvegicus
Lewin, T.M.; Schwerbrock, N.M.; Lee, D.P.; Coleman, R.A.
Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria
J. Biol. Chem.
279
13488-13495
2004
Mus musculus
Roy, A.; Guha, N.; Veras, I.D.; Chakraborty, S.; Haldar, D.
Stimulation of rat liver mitochondrial sn-glycerol-3-phosphate acyltransferase by polymyxin B via enhanced extraction of lysophosphatidic acid
Lipids
38
965-972
2003
Rattus norvegicus
Zufferey, R.; Mamoun, C.B.
The initial step of glycerolipid metabolism in Leishmania major promastigotes involves a single glycerol-3-phosphate acyltransferase enzyme important for the synthesis of triacylglycerol but not essential for virulence
Mol. Microbiol.
56
800-810
2005
Leishmania major
Kump, D.S.; Laye, M.J.; Booth, F.W.
Increased mitochondrial glycerol-3-phosphate acyltransferase protein and enzyme activity in rat epididymal fat upon cessation of wheel running
Am. J. Physiol. Endocrinol. Metab.
290
E480-E489
2006
Rattus norvegicus (P97564)
Pellon-Maison, M.; Coleman, R.A.; Gonzalez-Baro, M.R.
The C-terminal region of mitochondrial glycerol-3-phosphate acyltransferase-1 interacts with the active site region and is required for activity
Arch. Biochem. Biophys.
450
157-166
2006
Rattus norvegicus
Collison, L.M.; Kannan, L.; Onorato, T.M.; Knudsen, J.; Haldar, D.; Jolly, C.A.
Aging reduces glycerol-3-phosphate acyltransferase activity in activated rat splenic T-lymphocytes
Biochim. Biophys. Acta
1687
164-172
2005
Rattus norvegicus (P97564)
Collison, L.W.; Jolly, C.A.
Phosphorylation regulates mitochondrial glycerol-3-phosphate-1 acyltransferase activity in T-lymphocytes
Biochim. Biophys. Acta
1761
129-139
2006
Rattus norvegicus (P97564)
Linden, D.; William-Olsson, L.; Ahnmark, A.; Ekroos, K.; Hallberg, C.; Sjoegren, H.P.; Becker, B.; Svensson, L.; Clapham, J.C.; Oscarsson, J.; Schreyer, S.
Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
FASEB J.
20
434-443
2006
Mus musculus (Q61586), Mus musculus
Hammond, L.E.; Neschen, S.; Romanelli, A.J.; Cline, G.W.; Ilkayeva, O.R.; Shulman, G.I.; Muoio, D.M.; Coleman, R.A.
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs
J. Biol. Chem.
280
25629-25636
2005
Mus musculus
Nagle, C.A.; An, J.; Shiota, M.; Torres, T.P.; Cline, G.W.; Liu, Z.X.; Wang, S.; Catlin, R.L.; Shulman, G.I.; Newgard, C.B.; Coleman, R.A.
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
J. Biol. Chem.
282
14807-14815
2007
Rattus norvegicus
Cao, J.; Li, J.L.; Li, D.; Tobin, J.F.; Gimeno, R.E.
Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis
Proc. Natl. Acad. Sci. USA
103
19695-19700
2006
Homo sapiens, Mus musculus
Wang, S.; Lee, D.P.; Gong, N.; Schwerbrock, N.M.; Mashek, D.G.; Gonzalez-Baro, M.R.; Stapleton, C.; Li, L.O.; Lewin, T.M.; Coleman, R.A.
Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)
Arch. Biochem. Biophys.
465
347-358
2007
Mus musculus
Aneja, K.K.; Guha, P.; Shilpi, R.Y.; Chakraborty, S.; Schramm, L.M.; Haldar, D.
The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase
Arch. Biochem. Biophys.
470
35-43
2008
Rattus norvegicus (P97564)
Yazdi, M.; Ahnmark, A.; William-Olsson, L.; Snaith, M.; Turner, N.; Osla, F.; Wedin, M.; Asztely, A.K.; Elmgren, A.; Bohlooly-Y, M.; Schreyer, S.; Linden, D.
The role of mitochondrial glycerol-3-phosphate acyltransferase-1 in regulating lipid and glucose homeostasis in high-fat diet fed mice
Biochem. Biophys. Res. Commun.
369
1065-1070
2008
Mus musculus
Pellon-Maison, M.; Montanaro, M.A.; Coleman, R.A.; Gonzalez-Baro, M.R.
Mitochondrial glycerol-3-P acyltransferase 1 is most active in outer mitochondrial membrane but not in mitochondrial associated vesicles (MAV)
Biochim. Biophys. Acta
1771
830-838
2007
Rattus norvegicus
Lewin, T.M.; de Jong, H.; Schwerbrock, N.J.; Hammond, L.E.; Watkins, S.M.; Combs, T.P.; Coleman, R.A.
Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation during lipogenic diet and altered phospholipid fatty acid composition
Biochim. Biophys. Acta
1781
352-358
2008
Mus musculus
Hammond, L.E.; Albright, C.D.; He, L.; Rusyn, I.; Watkins, S.M.; Doughman, S.D.; Lemasters, J.J.; Coleman, R.A.
Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice
Exp. Mol. Pathol.
82
210-219
2007
Mus musculus
Chen, Y.Q.; Kuo, M.S.; Li, S.; Bui, H.H.; Peake, D.A.; Sanders, P.E.; Thibodeaux, S.J.; Chu, S.; Qian, Y.W.; Zhao, Y.; Bredt, D.S.; Moller, D.E.; Konrad, R.J.; Beigneux, A.P.; Young, S.G.; Cao, G.
AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase
J. Biol. Chem.
283
10048-10057
2008
Homo sapiens
Yan, K.; Chen, N.; Qu, Y.Y.; Dong, X.C.; Meng, Q.W.; Zhao, S.J.
Overexpression of sweet pepper glycerol-3-phosphate acyltransferase gene enhanced thermotolerance of photosynthetic apparatus in transgenic tobacco
J. Integr. Plant Biol.
50
613-621
2008
Capsicum annuum (Q7XYH5)
Gimeno, R.E.; Cao, J.
Thematic review series: glycerolipids. Mammalian glycerol-3-phosphate acyltransferases: new genes for an old activity
J. Lipid Res.
49
2079-2088
2008
Mammalia
Nagle, C.A.; Vergnes, L.; Dejong, H.; Wang, S.; Lewin, T.M.; Reue, K.; Coleman, R.A.
Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice
J. Lipid Res.
49
823-831
2008
Mus musculus
Harada, N.; Hara, S.; Yoshida, M.; Zenitani, T.; Mawatari, K.; Nakano, M.; Takahashi, A.; Hosaka, T.; Yoshimoto, K.; Nakaya, Y.
Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1)
Mol. Cell. Biochem.
297
41-51
2007
Mus musculus (Q14DK4), Mus musculus
Sui, N.; Li, M.; Liu, X.; Wang, N.; Fang, W.; Meng, Q.
Response of xanthophyll cycle and chloroplastic antioxidant enzymes to chilling stress in tomato over-expressing glycerol-3-phosphate acyltransferase gene
Photosynthetica
45
447-454
2007
Solanum lycopersicum (Q1PA40)
-
Sui, N.; Li, M.; Shu, D.; Zhao, S.; Meng, Q.
Antisense-mediated depletion of tomato chloroplast glycerol-3-phosphate acyltransferase affects male fertility and increases thermal tolerance
Physiol. Plant.
130
301-314
2007
Solanum lycopersicum (Q1PA40)
Sui, N.; Li, M.; Zhao, S.J.; Li, F.; Liang, H.; Meng, Q.W.
Overexpression of glycerol-3-phosphate acyltransferase gene improves chilling tolerance in tomato
Planta
226
1097-1108
2007
Solanum lycopersicum (Q1PA40), Solanum lycopersicum
Qiu, Q.; Liu, G.; Li, W.; Shi, Q.; Zhu, F.; Lu, G.
Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis
Acta Biochim. Biophys. Sin.
41
668-676
2009
Mus musculus (Q8K2C8), Mus musculus
Takeuchi, K.; Reue, K.
Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis
Am. J. Physiol. Endocrinol. Metab.
296
E1195-E1209
2009
Rattus norvegicus, Rattus norvegicus (P97564), Mus musculus (Q14DK4), Mus musculus (Q61586), Mus musculus (Q8C0N2), Mus musculus (Q8K2C8), Mus musculus, Homo sapiens (Q53EU6), Homo sapiens (Q86UL3), Homo sapiens
Bronnikov, G.E.; Aboulaich, N.; Vener, A.V.; Stralfors, P.
Acute effects of insulin on the activity of mitochondrial GPAT1 in primary adipocytes
Biochem. Biophys. Res. Commun.
367
201-207
2008
Rattus norvegicus
Hiromasa, Y.; Yan, X.; Roche, T.E.
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r
Biochemistry
47
2312-2324
2008
Mus musculus
Yoshida, M.; Harada, N.; Yamamoto, H.; Taketani, Y.; Nakagawa, T.; Yin, Y.; Hattori, A.; Zenitani, T.; Hara, S.; Yonemoto, H.; Nakamura, A.; Nakano, M.; Mawatari, K.; Teshigawara, K.; Arai, H.; Hosaka, T.; Takahashi, A.; Yoshimoto, K.; Nakaya, Y.
Identification of cis-acting promoter sequences required for expression of the glycerol-3-phosphate acyltransferase 1 gene in mice
Biochim. Biophys. Acta
1791
39-52
2009
Mus musculus
Bratschi, M.W.; Burrowes, D.P.; Kulaga, A.; Cheung, J.F.; Alvarez, A.L.; Kearley, J.; Zaremberg, V.
Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth
Eukaryot. Cell
8
1184-1196
2009
Saccharomyces cerevisiae
Wydysh, E.A.; Medghalchi, S.M.; Vadlamudi, A.; Townsend, C.A.
Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors
J. Med. Chem.
52
3317-3327
2009
Homo sapiens
Karlsson, E.A.; Wang, S.; Shi, Q.; Coleman, R.A.; Beck, M.A.
Glycerol-3-phosphate acyltransferase 1 is essential for the immune response to infection with coxsackievirus B3 in mice
J. Nutr.
139
779-783
2009
Mus musculus
Pellon-Maison, M.; Garcia, C.F.; Cattaneo, E.R.; Coleman, R.A.; Gonzalez-Baro, M.R.
Macrobrachium borellii hepatopancreas contains a mitochondrial glycerol-3-phosphate acyltransferase which initiates triacylglycerol biosynthesis
Lipids
44
337-344
2009
Macrobrachium borellii
Gidda, S.K.; Shockey, J.M.; Rothstein, S.J.; Dyer, J.M.; Mullen, R.T.
Arabidopsis thaliana GPAT8 and GPAT9 are localized to the ER and possess distinct ER retrieval signals: functional divergence of the dilysine ER retrieval motif in plant cells
Plant Physiol. Biochem.
47
867-879
2009
Arabidopsis thaliana (Q5XF03), Arabidopsis thaliana (Q8GWG0), Arabidopsis thaliana
Ruiz-Lopez, N.; Garces, R.; Harwood, J.L.; Martinez-Force, E.
Characterization and partial purification of acyl-CoA:glycerol 3-phosphate acyltransferase from sunflower (Helianthus annuus L.) developing seeds
Plant Physiol. Biochem.
48
73-80
2009
Helianthus annuus
Nakagawa, T.; Harada, N.; Miyamoto, A.; Kawanishi, Y.; Yoshida, M.; Shono, M.; Mawatari, K.; Takahashi, A.; Sakaue, H.; Nakaya, Y.
Membrane topology of murine glycerol-3-phosphate acyltransferase 2
Biochem. Biophys. Res. Commun.
418
506-511
2012
Mus musculus (Q14DK4), Mus musculus
Wydysh, E.A.; Vadlamudi, A.; Medghalchi, S.M.; Townsend, C.A.
Design, synthesis, and biological evaluation of conformationally constrained glycerol 3-phosphate acyltransferase inhibitors
Bioorg. Med. Chem.
18
6470-6479
2010
Homo sapiens, Cucurbita moschata (P10349)
Marr, N.; Foglia, J.; Terebiznik, M.; Athenstaedt, K.; Zaremberg, V.
Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation
J. Biol. Chem.
287
10251-10264
2012
Saccharomyces cerevisiae (P36148), Saccharomyces cerevisiae
Li, X.C.; Zhu, J.; Yang, J.; Zhang, G.R.; Xing, W.F.; Zhang, S.; Yang, Z.N.
Glycerol-3-phosphate acyltransferase 6 (GPAT6) is important for tapetum development in Arabidopsis and plays multiple roles in plant fertility
Mol. Plant
5
131-142
2012
Arabidopsis thaliana
Stapleton, C.; Mashek, D.; Wang, S.; Nagle, C.; Cline, G.; Thuillier, P.; Leesnitzer, L.; Li, L.; Stimmel, J.; Shulman, G.; Coleman, R.
Lysophosphatidic acid activates peroxisome proliferator activated receptor-gamma in CHO cells that over-express glycerol 3-phosphate acyltransferase-1
PLoS ONE
6
e18932
2011
Rattus norvegicus (P97564)
Cattaneo, E.R.; Pellon-Maison, M.; Rabassa, M.E.; Lacunza, E.; Coleman, R.A.; Gonzalez-Baro, M.R.
Glycerol-3-phosphate acyltransferase-2 is expressed in spermatic germ cells and incorporates arachidonic acid into triacylglycerols
PLoS ONE
7
e42986
2012
Rattus norvegicus (D3ZI76)
Gao, Q.; Shang, Y.; Huang, W.; Wang, C.
Glycerol-3-phosphate acyltransferase contributes to triacylglycerol biosynthesis, lipid droplet formation, and host invasion in Metarhizium robertsii
Appl. Environ. Microbiol.
79
7646-7653
2013
Metarhizium robertsii, Metarhizium robertsii ARSEF2575
Li, C.; Pan, L.; Wang, Y.; Wang, J.; Ding, Z.
Codon bias of the gene for chloroplast glycerol-3-phosphate acyltransferase in Camellia sinensis (L.) O. Kuntze
Biochem. Syst. Ecol.
55
212-218
2014
Camellia sinensis (S5W1E8)
-
Faris, R.; Fan, Y.Y.; De Angulo, A.; Chapkin, R.S.; deGraffenried, L.A.; Jolly, C.A.
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4(+) T cell metabolic activation
Biochim. Biophys. Acta
1842
1475-1482
2014
Mus musculus
Wendel, A.A.; Cooper, D.E.; Ilkayeva, O.R.; Muoio, D.M.; Coleman, R.A.
Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation
J. Biol. Chem.
288
27299-27306
2013
Mus musculus, Mus musculus (Q61586)
Cooper, D.E.; Grevengoed, T.J.; Klett, E.L.; Coleman, R.A.
Glycerol-3-phosphate acyltransferase isoform-4 (GPAT4) limits oxidation of exogenous fatty acids in brown adipocytes
J. Biol. Chem.
290
15112-15120
2015
Mus musculus (Q8K2C8)
Faris, R.; Weber, M.M.; Seeger, D.R.; Cavazos, D.; de Graffenried, L.; Murphy, E.J.; Jolly, C.A.
Mitochondrial glycerol-3-phosphate acyltransferase-dependent phospholipid synthesis modulates phospholipid mass and IL-2 production in Jurkat T cells
Lipids
51
291-301
2016
Homo sapiens
Paya-Milans, M.; Venegas-Caleron, M.; Salas, J.J.; Garces, R.; Martinez-Force, E.
Cloning, heterologous expression and biochemical characterization of plastidial sn-glycerol-3-phosphate acyltransferase from Helianthus annuus
Phytochemistry
111
27-36
2015
Helianthus annuus (K9JTB0), Helianthus annuus
Shockey, J.; Regmi, A.; Cotton, K.; Adhikari, N.; Browse, J.; Bates, P.D.
Identification of Arabidopsis GPAT9 (At5g60620) as an essential gene involved in triacylglycerol biosynthesis
Plant Physiol.
170
163-179
2016
Arabidopsis thaliana (Q8GWG0)
Du, M.; Liu, X.; Liu, X.; Yin, X.; Han, S.; Song, Q.; An, S.
Glycerol-3-phosphate O-acyltransferase is required for PBAN-induced sex pheromone biosynthesis in Bombyx mori
Sci. Rep.
5
8110
2015
Bombyx mori
Baral, M.; Misra, N.; Panda, P.; Thirunavoukkarasu, M.
In silico structural determination of gpat enzyme from Ostreococcus lucimarinus for biotechnological application of microalgal biofuel production
Biotechnol. Biotechnol. Equip.
26
2794-2800
2012
Ostreococcus sp. 'lucimarinus' (A4RT23), Ostreococcus sp. 'lucimarinus' CCE9901 (A4RT23)
-
Fitzpatrick, S.M.; Sorresso, G.; Haldar, D.
Acyl-CoA sn-glycerol-3-phosphate O-acyltransferase in rat brain mitochondria and microsomes
J. Neurochem.
39
286-289
1982
Rattus norvegicus (P97564), Rattus norvegicus (Q4V8J4)
Huang, L.; Yu, L.; Li, Z.; Li, Y.; Yoon, K.; Hu, Q.; Yuan, L.; Han, D.
Microalgal plastidial lysophosphatidic acid acyltransferase interacts with upstream glycerol-3-phosphate acyltransferase and defines its substrate selectivity via the two transmembrane domains
Algal Res.
45
101758
2020
Chlamydomonas reinhardtii (A0A2K3E3Z9)
-
Garcia-Fabiani, M.B.; Montanaro, M.A.; Stringa, P.; Lacunza, E.; Cattaneo, E.R.; Santana, M.; Pellon-Maison, M.; Gonzalez-Baro, M.R.
Glycerol-3-phosphate acyltransferase 2 is essential for normal spermatogenesis
Biochem. J.
474
3093-3107
2017
Mus musculus (Q14DK4), Mus musculus
Quiroga, I.Y.; Pellon-Maison, M.; Suchanek, A.L.; Coleman, R.A.; Gonzalez-Baro, M.R.
Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages
Biochem. J.
476
85-99
2019
Mus musculus (Q8C0N2), Mus musculus (Q8K2C8), Mus musculus C57Bl6/J (Q8C0N2), Mus musculus C57Bl6/J (Q8K2C8)
Lee, J.; Ridgway, N.
Substrate channeling in the glycerol-3-phosphate pathway regulates the synthesis, storage and secretion of glycerolipids
Biochim. Biophys. Acta
1865
158438
2020
Mus musculus (Q14DK4), Mus musculus (Q61586), Mus musculus (Q8C0N2), Mus musculus (Q8K2C8), Homo sapiens (Q53EU6), Homo sapiens (Q6NUI2), Homo sapiens (Q86UL3), Homo sapiens (Q9HCL2)
Niu, Y.F.; Wang, X.; Hu, D.X.; Balamurugan, S.; Li, D.W.; Yang, W.D.; Liu, J.S.; Li, H.Y.
Molecular characterization of a glycerol-3-phosphate acyltransferase reveals key features essential for triacylglycerol production in Phaeodactylum tricornutum
Biotechnol. Biofuels
9
60
2016
Phaeodactylum tricornutum (B7FRB8), Phaeodactylum tricornutum, Phaeodactylum tricornutum CCAP 1055/1 (B7FRB8)
Zhang, L.; Luo, H.; Zhao, Y.; Chen, X.; Huang, Y.; Yan, S.; Li, S.; Liu, M.; Huang, W.; Zhang, X.; Jin, W.
Maize male sterile 33 encodes a putative glycerol-3-phosphate acyltransferase that mediates anther cuticle formation and microspore development
BMC Plant Biol.
18
318
2018
Zea mays (A0A1D6F8B0), Zea mays (A0A1D6JQM9), Zea mays
Keenan, K.A.; Grove, T.J.; Oldham, C.A.; OBrien, K.M.
Characterization of mitochondrial glycerol-3-phosphate acyltransferase in notothenioid fishes
Comp. Biochem. Physiol. B
204
9-26
2017
Chaenocephalus aceratus (A0A288TFU7), Chaenocephalus aceratus, Notothenia coriiceps (A0A288TG08), Notothenia coriiceps, Eleginops maclovinus (A0A288TG42), Eleginops maclovinus
Ouyang, L.L.; Li, H.; Yan, X.J.; Xu, J.L.; Zhou, Z.G.
Site-directed mutagenesis from Arg195 to His of a microalgal putatively chloroplastidial glycerol-3-phosphate acyltransferase causes an increase in phospholipid levels in yeast
Front. Plant Sci.
7
286
2016
Lobosphaera incisa (A0A0B5EHP8), Lobosphaera incisa, Lobosphaera incisa H4301 (A0A0B5EHP8)
Sui, N.; Tian, S.; Wang, W.; Wang, M.; Fan, H.
Overexpression of glycerol-3-phosphate acyltransferase from Suaeda salsa improves salt tolerance in Arabidopsis
Front. Plant Sci.
8
1337
2017
Suaeda salsa, Arabidopsis thaliana (Q9FZ22), Arabidopsis thaliana Col-0 (Q9FZ22)
Khatun, I.; Clark, R.; Vera, N.; Kou, K.; Erion, D.; Coskran, T.; Bobrowski, W.; Okerberg, C.; Goodwin, B.
Characterization of a novel intestinal glycerol-3-phosphate acyltransferase pathway and its role in lipid homeostasis
J. Biol. Chem.
291
2602-2615
2016
Mus musculus (Q8C0N2), Mus musculus
Patel, N.; Pirani, K.A.; Zhu, T.; Cheung-See-Kit, M.; Lee, S.; Chen, D.G.; Zufferey, R.
The glycerol-3-phosphate acyltransferase TbGAT is dispensable for viability and the synthesis of glycerolipids in Trypanosoma brucei
J. Eukaryot. Microbiol.
63
598-609
2016
Trypanosoma brucei brucei (Q38BT6), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q38BT6)
Singer, S.D.; Chen, G.; Mietkiewska, E.; Tomasi, P.; Jayawardhane, K.; Dyer, J.M.; Weselake, R.J.
Arabidopsis GPAT9 contributes to synthesis of intracellular glycerolipids but not surface lipids
J. Exp. Bot.
67
4627-4638
2016
Arabidopsis thaliana (Q8GWG0)
Men, X.; Shi, J.; Liang, W.; Zhang, Q.; Lian, G.; Quan, S.; Zhu, L.; Luo, Z.; Chen, M.; Zhang, D.
Glycerol-3-phosphate acyltransferase 3 (OsGPAT3) is required for anther development and male fertility in rice
J. Exp. Bot.
68
513-526
2017
Oryza sativa (Q2QZN3), Oryza sativa
Jayawardhane, K.N.; Singer, S.D.; Weselake, R.J.; Chen, G.
Plant sn-glycerol-3-phosphate acyltransferases biocatalysts involved in the biosynthesis of intracellular and extracellular lipids
Lipids
53
469-480
2018
Arabidopsis thaliana (Q5XF03), Arabidopsis thaliana (Q8GWG0), Arabidopsis thaliana (Q9CAY3), Arabidopsis thaliana (Q9FZ22), Arabidopsis thaliana (Q9LHS7), Arabidopsis thaliana (Q9SHJ5), Arabidopsis thaliana (Q9SYJ2)
Law, J.D.; Daniel, J.
The mycobacterial Rv1551 glycerol-3-phosphate acyltransferase enhances phospholipid biosynthesis in cell lysates of Escherichia coli
Microb. Pathog.
113
269-275
2017
Mycobacterium tuberculosis (P9WI59), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WI59), Mycobacterium tuberculosis ATCC 25618 (P9WI59)
Yu, J.; Loh, K.; Song, Z.Y.; Yang, H.Q.; Zhang, Y.; Lin, S.
Update on glycerol-3-phosphate acyltransferases the roles in the development of insulin resistance
Nutr. Diabetes
8
34
2018
Mus musculus (Q14DK4), Mus musculus (Q61586), Mus musculus (Q8C0N2), Mus musculus (Q8K2C8), Homo sapiens (Q53EU6), Homo sapiens (Q86UL3), Homo sapiens (Q9HCL2), Mus musculus C57BL/6J (Q8K2C8)
Yang, S.U.; Kim, J.; Kim, H.; Suh, M.C.
Functional characterization of Physcomitrella patens glycerol-3-phosphate acyltransferase 9 and an increase in seed oil content in Arabidopsis by its ectopic expression
Plants (Basel)
8
284-300
2019
Physcomitrium patens (A9SYM2), Physcomitrium patens
Nutahara, E.; Abe, E.; Uno, S.; Ishibashi, Y.; Watanabe, T.; Hayashi, M.; Okino, N.; Ito, M.
The glycerol-3-phosphate acyltransferase PLAT2 functions in the generation of DHA-rich glycerolipids in Aurantiochytrium limacinum F26-b
PLoS ONE
14
e0211164
2019
Aurantiochytrium limacinum (A0A387K406), Aurantiochytrium limacinum, Aurantiochytrium limacinum F26-b (A0A387K406)
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