2.7.1.76: 2'-deoxyadenosine kinase

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For detailed information about 2'-deoxyadenosine kinase, go to the full flat file.

Reaction

Synonyms

dAdo/dCyd kinase, dAK, dCK, dCyd kinase/dAdo kinase I, deoxyadenosine kinase, deoxycytidine kinase/deoxyadenosine kinase, dCK/dAK, deoxyguanosine kinase/deoxyadenosine kinase, dGK/dAK, dGuo kinase/dAdo kinase II, kinase, deoxyadenosine (phosphorylating), More, purine-deoxyribonucleoside kinase

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.76 2'-deoxyadenosine kinase

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Results	in table
7	Activating Compound
492	AA Sequence
1	Application
1	CAS Registry Number
7	Cloned(Commentary)
15	Cofactor
3	Crystallization (Commentary)
5	General Stability
29	Inhibitors
8	Ki Value [mM]
50	KM Value [mM]
3	Localization
11	Metals/Ions
10	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
45	Organism
5	Pathway
2	PDB ID
4	pH Optimum
2	pH Range
1	pH Stability
14	Protein Variants
11	Purification (Commentary)
2	Reaction
1	Reaction Type
37	Reference
22	Source Tissue
10	Specific Activity [micromol/min/mg]
4	Storage Stability
147	Substrates and Products (Substrate)
10	Subunits
27	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
19	Turnover Number [1/s]

Application

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Application on EC 2.7.1.76 - 2'-deoxyadenosine kinase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

-

thymocytes lacking adenosine deaminase activity accumulate intracellular dATP and undergo apoptosis. Inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates accumulation of dATP and significantly reduces the induction of apoptosis

694483