2.7.1.6: galactokinase
This is an abbreviated version!
For detailed information about galactokinase, go to the full flat file.
Word Map on EC 2.7.1.6
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2.7.1.6
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galactose-1-phosphate
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galactosemia
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cataract
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leloir
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uridyltransferase
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lambda
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gale
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uridyl
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thymidine
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bacteriophage
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udp-galactose
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1-phosphate
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epimerase
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lactis
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galactitol
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inborn
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udp-glucose
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kluyveromyces
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pyrophosphorylase
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gal-1-p
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presenile
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rho-dependent
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coliphage
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antitermination
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phosphomevalonate
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galactose-induced
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4'-epimerase
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glucose-1-phosphate
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counterselection
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udp-galactose-4-epimerase
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medicine
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synthesis
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nutrition
- 2.7.1.6
- galactose-1-phosphate
- galactosemia
- cataract
-
leloir
- uridyltransferase
- lambda
-
gale
-
uridyl
- thymidine
- bacteriophage
- udp-galactose
- 1-phosphate
-
epimerase
- lactis
- galactitol
-
inborn
- udp-glucose
- kluyveromyces
-
pyrophosphorylase
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gal-1-p
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presenile
-
rho-dependent
-
coliphage
-
antitermination
- phosphomevalonate
-
galactose-induced
-
4'-epimerase
- glucose-1-phosphate
-
counterselection
- udp-galactose-4-epimerase
- medicine
- synthesis
- nutrition
Reaction
Synonyms
atgalk, ATP:D-galactose-1-phosphotransferase, BiGalK, CLB.507001.110, CLB.510667.120, GAL1, Gal1p, galactokinase, galactokinase 1, galactose kinase, GALK, GALK1, GalKAmu, GalKSpe4, kinase (phosphorylating), galacto-, kinase, galacto- (phosphorylating), SCO3136
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.7.1.6 - galactokinase
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REACTION DIAGRAM
ADP + alpha-D-galactose 1-phosphate
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?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
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-
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?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
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-
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?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
the enzyme catalyses the first committed step in the Leloir pathway
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-
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
involved in Leloir pathway
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-
?
ATP + alpha-D-galactose
ADP + alpha-D-galactose 1-phosphate
involved in Leloir pathway
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?
ADP + alpha-D-galactose 1-phosphate
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the enzyme catalyzes the first step in the conversion of galactose to glucose. Galactokinase deficiency is characterized by galactosemia, galactosuria and cataract formation in early childhood
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-
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
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galactokinase deficiency is an autosomal recessive disorder, which causes cataract formation in children not maintained on a lactose-free diet
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-
?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
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galaktokinase deficiency is an autosomal recessive disorder characterized by hypergalactosemia and cataract formation
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?
ATP + galactose
ADP + alpha-D-galactose 1-phosphate
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lack of fully functional galactokinase is one cause of the inherited disease galactosemia, the main clinical manifestation of which is the early onset of cataracts
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ATP + galactose
ADP + alpha-D-galactose 1-phosphate
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first step in the Leloir pathway for galactose metabolism
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-
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galactokinase Gal1p is a regulator of transcription. Gal1p activates Gal4p, the activator of GAL genes. Gal1p activates Gal4p by direct interaction with the Gal4p inhibitor Gal80p. Interaction requires galactose, adenosine triphosphate and the regulatory function of Gal1p. The gal1p-gal80p complex formation results in the inactivation of Gal80p, thereby transmitting the galactose signal to Gal4p
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additional information
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key enzyme for cellulase induction during growth on lactose
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additional information
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induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina
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additional information
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induction of the gal pathway and cellulase genes involves no transcriptional inducer function of the galactokinase in Hypocrea jecorina
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?