2.7.1.46: L-arabinokinase
This is an abbreviated version!
For detailed information about L-arabinokinase, go to the full flat file.
Word Map on EC 2.7.1.46
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2.7.1.46
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fructose
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2.7.1.4
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6-phosphotransferase
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ketohexokinase
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hexokinases
- 2.7.1.46
- fructose
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2.7.1.4
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6-phosphotransferase
- ketohexokinase
- hexokinases
Reaction
Synonyms
ARA1, ARA2, arabinokinase, arabinokinase-like protein, At3g42850, At4g16130, collapsed abnormal pollen1, kinase (phosphorylating), L-arabino-, kinase, L-arabino- (phosphorylating), mevalonate/galactokinase family protein
ECTree
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General Information
General Information on EC 2.7.1.46 - L-arabinokinase
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evolution
arabinokinase is a GHMP (galactose, homoserine, mevalonate, phosphomevalonate) kinase with a unique structure that is highly conserved in plants. Isozymes Ara1 and Ara2 share 71% amino acid identity
malfunction
physiological function
exogenous L-arabinose and its cellular accumulation are lethal for the point mutation variant ara1-1. Ara1-1 displays a lethal phenotype only upon L-arabinose treatment. The amino acid exchange of ARA1-1 is part of a conserved alpha-helix. The mutation borders a SSSAA motif which is present in both kinases and plays a role in creating the binding pocket surface. The model and alignments of both proteins show that the amino acid exchange site is closely located at the entrance of the substrate binding pocket. Recombinant Nicotiana benthamiana leaves infiltrated with ARA1 and ARA1-1 constructs show first signs of necrosis after 3 days at the sites of infiltration
malfunction
exogenous L-arabinose and its cellular accumulation are not lethal for the ara1-2 knockout plant. Recombinant Nicotiana benthamiana leaves infiltrated with ARA2 and ARA2-1 constructs show first signs of necrosis after 3 days at the sites of infiltration
physiological function
role of arabinokinase in arabinose toxicity in plants