2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase
This is an abbreviated version!
For detailed information about phosphatidylinositol-4-phosphate 3-kinase, go to the full flat file.
Word Map on EC 2.7.1.154
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2.7.1.154
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wortmannin
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chemotaxis
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pi3kgamma
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p110alpha
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ptdins3,4,5p3
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pten
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3,4,5-trisphosphate
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p110delta
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pleckstrin
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p110gamma
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ptdins3p
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gpcrs
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rac
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isoform-selective
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pi3-kinase
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pi3k-dependent
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pi3kalpha
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ptdins3,4p2
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p85alpha
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3-phosphoinositides
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3,4-bisphosphate
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3-kinase-dependent
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pi3-ks
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pi3kdelta
-
kinase-dead
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gbetagamma
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drug development
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diagnostics
- 2.7.1.154
- wortmannin
-
chemotaxis
- pi3kgamma
- p110alpha
-
ptdins3,4,5p3
- pten
-
3,4,5-trisphosphate
- p110delta
-
pleckstrin
-
p110gamma
- ptdins3p
-
gpcrs
- rac
-
isoform-selective
- pi3-kinase
-
pi3k-dependent
- pi3kalpha
-
ptdins3,4p2
-
p85alpha
- 3-phosphoinositides
- 3,4-bisphosphate
-
3-kinase-dependent
- pi3-ks
- pi3kdelta
-
kinase-dead
- gbetagamma
- drug development
- diagnostics
Reaction
Synonyms
C2-domain-containing phosphoinositide 3-kinase, C2-PI3K, class I phosphoinositide 3-kinase, class II phosphoinositide 3 kinase alpha subunit, class II phosphoinositide 3-kinase, class II phosphoinositide 3-kinase alpha, class II phosphoinositide 3-kinase alpha-isoform, class II phosphoinositide 3-kinase C2alpha, class II phosphoinositide 3-kinase C2beta, class II phosphoinositide 3-kinases PI3K-C2alpha, class II PI3K, class II PI3K-C2alpha, class III phosphoinositide 3-kinase, class-I PI 3-kinase, class-II PI 3-kinase, HsC3-PI3K, kinase (phosphorylating), phosphatidylinositol 4-phosphate 3-, p170, phosphatidylinositol 3-kinase class 2 beta, phosphatidylinositol 3-kinase class II alpha, phosphoinositide 3-kinase, phosphoinositide 3-kinase C2 beta, phosphoinositide 3-kinase C2beta, phosphoinositide 3-kinase-C2-beta, phosphoinositide 3-kinase-C2-gamma, phosphoinositide 3-kinases, PI 3-kinase, PI 3-kinase C2alpha, PI 3-kinase C2beta, PI 3-kinase C2gamma, PI3K, PI3K-C2alpha, PI3K-C2beta, PI3K-C2gamma, PI3KC2a, PI3KC2alpha, PI3KC2b, PI3KC2beta, PI3KC2gamma, PI3K_68D, PI3K_C2alpha, PI3K_C2gamma, PIK3C2G, PtdIns-3-kinase C2alpha, PtdIns-3-kinase C2beta, PtdIns-3-kinase C2gamma, type II phosphoinositide 3-kinase
ECTree
2.7.1.154 phosphatidylinositol-4-phosphate 3-kinaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate
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strong preference for phosphatidylinositol over 1-phosphatidyl-1D-myo-inositol-4-phosphate
-
-
?
ATP + phosphatidylinositol
?
-
strong preference for phosphatidylinositol over 1-phosphatidyl-1D-myo-inositol-4-phosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
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preferred substrate of enzyme form PI3K-C2beta
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol
ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
-
preferred substrate of enzyme form PI3K-C2beta
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
at 10% of the activity with phosphatidylinositol, phosphorylation only in presence of Mg2+, not in presence of Ca2+
-
?
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
-
?
ATP + 1-phosphatidyl-1D-myo-inositol-4-phosphate
ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
-
-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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-
-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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-
-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
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-
-
?
ATP + phosphatidylinositol
ADP + phosphatidylinositol 3-phosphate
-
-
-
?
ATP + phosphoinositides
ADP + ?
enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview
-
-
?
ATP + phosphoinositides
ADP + ?
phosphorylation of the D-3 position on the inositol ring
-
-
?
ATP + phosphoinositides
ADP + ?
enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview
-
-
?
ATP + phosphoinositides
ADP + ?
phosphorylation of the D-3 position on the inositol ring
-
-
?
ATP + phosphoinositides
ADP + ?
enzyme plays a role in cellular signalling pathways, e.g. the insulin signalling pathways acting via class Ia and PI3K-C2alpha isozymes synthesizing 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate and affecting the glucose metabolism, the enzyme antagonizes with phosphatases both regulating the signalling pathways together, the enzyme is also involved in insulin resistance in peripheral tissues, overview
-
-
?
ATP + phosphoinositides
ADP + ?
phosphorylation of the D-3 position on the inositol ring
-
-
?
additional information
?
-
no activity with phosphatidylinositol 4,5-diphosphate
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-
?
additional information
?
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the isozymes interact with and effect patterning of receptor signaling pathways, overview
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-
?
additional information
?
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the class II phosphoinositide 3-kinase C2.alpha. is activated by clathrin and regulates clathrin-mediated membrane trafficking
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-
?
additional information
?
-
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PI3K-C2alpha and PI3K-C2beta represent two downstream targets of the activated epidermal growth factor
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-
?
additional information
?
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isozyme PI3K-C2alpha is a crucial survival factor for the cell
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-
?
additional information
?
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the isozymes activate different signalling cascades via stem cell factor SCF in overexpressing cancer cell lines, e.g. association with c-Met, IGF-IR, regulation, class II PI3K C2beta blocks both protein kinase and small lung cell carcinoma in reponse to stem cell factor, polypeptide growth factors induce the recruitment of class IA and II isozymes to phosphotyrosine-containing signalling complexes, detailed overview
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-
?
additional information
?
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PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking.
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-
?
additional information
?
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PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking.
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?
additional information
?
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PI3KC2alpha functions in vascular smooth muscle contraction, priming of neurosecretory granule exocytosis, insulin signalling and clathrin-mediated membrane trafficking.
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?
additional information
?
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PI3KC2beta functions in cell migration, and PTK receptor signalling
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-
?
additional information
?
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PI3KC2beta functions in cell migration, and PTK receptor signalling
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-
?
additional information
?
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PI3KC2beta functions in cell migration, and PTK receptor signalling
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-
?
additional information
?
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PI3KC2beta regulates the migration and survival of human tumor cells by distinct molecular mechanisms. Phosphoinositide 3-kinase C2beta regulates cytoskeletal organization and cell migration via Rac-dependent mechanisms
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-
?
additional information
?
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ATP and substrate binding of PI3K isozymes, overview
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-
-
additional information
?
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ATP and substrate binding of PI3K isozymes, overview
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-
-
additional information
?
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ATP and substrate binding of PI3K isozymes, overview
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-
-
additional information
?
-
-
PI3K-C2alpha and PI3K-C2beta represent two downstream targets of the activated epidermal growth factor
-
-
?
additional information
?
-
-
the class II phosphoinositide 3-kinase C2.alpha. is activated by clathrin and regulates clathrin-mediated membrane trafficking
-
-
?
additional information
?
-
enzyme regulation, overview
-
-
?
additional information
?
-
-
TNFalpha and leptin stimulate the alpha-isoform of class II phosphoinositide 3-kinase
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-
?
additional information
?
-
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the enzyme is regulated by intracellular signalling mechanisms
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-
?
additional information
?
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ATP and substrate binding of PI3K isozymes, overview
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-
-
additional information
?
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ATP and substrate binding of PI3K isozymes, overview
-
-
-
additional information
?
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ATP and substrate binding of PI3K isozymes, overview
-
-
-
additional information
?
-
no activity with phosphatidylinositol 4,5-diphosphate
-
-
?
