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(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
(1E,4S,4aR,5R,6aS,7S)-5-(acetyloxy)-1-[[[3-(dimethylamino)-propyl](methyl)amino]methylene]-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-7-yl-(1R,2R,4S)-4-[(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl]-2-methoxycyclohexyl octanedioate
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(1E,4S,4aR,5R,6aS,7S)-5-(acetyloxy)-1-{[[3-(dimethylamino)propyl](methyl)amino]methylene}-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-7-yl-(1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl octanedioate
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(1E,4S,4aR,5R,6aS,7S,9aR)-1-({[3-(dimethylamino)propyl](methyl)amino}methylidene)-7,11-dihydroxy-4-(methoxymethyl)-4a,6a,9a-trimethyl-2,10-dioxo-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydroindeno[4,5-h]isochromen-5-yl acetate
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(1Z,4S,4aR,6aS,9aR)-1-([[3-(dimethylamino)propyl](methyl)amino]methylidene)-5-ethoxy-7,11-dihydroxy-4-(methoxymethyl)-4a,6a-dimethyl-4a,5,6,6a,7,8,9,9a-octahydroindeno[4,5-h]isochromene-2,10(1H,4H)-dione
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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-[(2R)-1-[(1S,3R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R)-3-hydroxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
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(8S)-2-[(3R)-3-methylmorpholin-4-yl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one
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1-((3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl)methyl)guanidine
i.e. idelalisib
1-([2-[(2-chloropyridin-4-yl)amino]-4'-(cyclopropylmethyl)[4,5'-bipyrimidin]-2'-yl]amino)-2-methylpropan-2-ol
Vpsn34-IN1
1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
2-morpholin-4-yl-3-phenylchromen-4-one
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weak inhibition, IC50 is above 0.2 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
2-morpholin-4-yl-3-propylchromen-4-one
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IC50 is 0.0031 mM for the recombinant wild-type enzyme and 0.068 mM for the recombinant mutant C838V/I848A
3-benzyl-2-morpholin-4-yl-chromen-4-one
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weak inhibition, IC50 is above 0.2 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
3-butyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.025 mM for the recombinant wild-type enzyme and 0.048 mM for the recombinant mutant C838V/I848A
3-ethyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.028 mM for the recombinant wild-type enzyme and 0.0044 mM for the recombinant mutant C838V/I848A
3-isopropyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.051 mM for the recombinant wild-type enzyme and more than 0.2 mM for the recombinant mutant C838V/I848A
3-methyl-2-morpholin-4-yl-chromen-4-one
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IC50 is 0.033 mM for the recombinant wild-type enzyme and 0.040 mM for the recombinant mutant C838V/I848A
5'-p-fluorosulfonylbenzoyladenosine
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apocynin
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specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim
Ca2+
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0.1 mM, 60% inhibition, in presence of 10 mM MgCl2
ethanol
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dose-dependent inhibition of insulin receptor substrate-1-associated PI3K activity in skeletal muscle, but not in adipose tissue, ethanol-induced diabetic rats
Gö6976
inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition
isoquercetin
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PI 3-kinase I and PI 3-kinase II; strong inhibition of PI 3-kinase I and II, noncompetitive, apparent Ki value: 4 mM for PI 3-kinase I and 2.5 mM for PI 3-kinase II
KU55933
inhibitor directly targets phosphatidylinositol 3-kinase and confers profound inhibition of autophagic flux by inhibiting the formation of autophagosomes. Inhibits wild-type activity in vitro almost as efficiently as LY294002. It does not inhibit the cell survival promoting class I phosphoinositide 3-kinase-Akt signaling at the concentrations required for effective autophagy inhibition
LY292223
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i.e. 2-morpholin-4-yl-chromen-4-one, IC50 is 0.0026 mM for the recombinant wild-type enzyme and 0.025 mM for the recombinant mutant C838V/I848A
LY303511
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the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.065 mM
lysophosphatidic acid
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Mg2+
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inhibition above 2.5 mM, activation below
peptide N24
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a peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase, N24, regulatory subunit acts as inhibitor in cancer therapy, it blocks cell proliferation and induces cell cycle arrest in all cancer cell lines tested. Modeling of mechanisms of Rb-dependent and Rb-independent cell cycle arrest by N24 peptide, overview
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PI3Kalpha inhibitor IV
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PI3Kbeta inhibitor VI
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i.e. TGX-221
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PI3Kgamma inhibitor
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proteinase K
proteinase K treatment of partially purified Rickettsia typhi results in a dose-dependent degradation of Risk1 on the bacterial membrane
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TGFbeta
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significantly inhibits phosphorylation of both p85 and ERK1/2 in vivo. TGFbeta does not activate the ERK pathway but turns off the GM-CSF-induced ERK signal via inhibition of the PI3-kinase-Akt pathway in human leukemia cells, overview
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Tiron
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specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim
ZSTK474
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a phosphatidylinositol 3-kinase inhibitor, inhibited phosphorylation of Ser65, Thr70 and Thr37/46 in 4E-BP1 by PI3K. Identification of the ZSTK474-sensitive phosphoproteins in A-549 cells, overview
(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
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(+/-)-2-[hydroxy[tetrahydro-2-(octadecyloxy)methylfuran-2-yl]methoxyl]phosphinyloxy-N,N,N-trimethylethaniminium hydroxide
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1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
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1-O-octadecyl-2-O-methyl-rac-3-glycerophospho-myo-inositol
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1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
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noncompetitive with ATP
1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine
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noncompetitive with ATP
17-hydroxywortmannin
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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i.e. LY294002
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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i.e. LY294002
3-Methyladenine
3-MA, a nonspecific inhibitor of PI 3-kinases
3-Methyladenine
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treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
3-Methyladenine
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treatment in full medium for a prolonged period of time leads to marked increases of the autophagic markers in cells. The increase of autophagic markers is the result of enhanced autophagic flux. The autophagy promotion activity is due to its differential temporal effects on class I and class III PI3K enzymes. 3-Methyladenine blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient. Treatment with 3-methyladenine in full medium significantly reduces the level of phosphatidylinositol 3-phosphate, the product of class III PI3K, at early time points, but almost completely blocks the product of phosphatidylinositol 3,4,5-trisphosphate up to 9 h
cardiolipin
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GDC-0941
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enzyme PI3K-inhibition via GDC-0941 and PTEN-reconstitution into PTEN-null follicular thyroid carcinomas FTC-133s. GDC-0941 inhibits radiation-induced activation of Ataxia-telangiectasia mutated (ATM), ATM-and Rad3-related (ATR) and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Under anoxia, radiation-induced PI3K-related kinase activation is markedly inhibited by GDC-0941. Inhibition of ATM and DNA-protein kinase catalytic subunits is PI3K-dependent
hexadecylphosphocholine
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hexadecylphosphocholine
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LY294002
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a PI3Kspecific inhibitor, inhibition in vivo: in LY294002-treated root hair cells, endocytosis at the stage of final fusion of the late endosomes to the tonoplast is inhibited and ROS level decreases in a dose-dependent manner, overview
LY294002
competes with ATP and binds to Lys residues in the ATP-binding pocket of PI3Ks
LY294002
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i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a specific cell-permeable PI3-K inhibitor, inhibits spermatozoa motility at 40°C, not at 30°C, independent of and not reversable by Ca2+
LY294002
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IC50 is 0.0011 mM for the recombinant wild-type enzyme and for the recombinant mutant C838V/I848A
LY294002
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the inhibitor activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901
LY294002
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could suppress leukemia cell invasion and migration at least in part through up-regulation of Egr-1, independent of its PI3 K-Akt inhibitory activity
LY294002
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inhibition of PI3K by LY294002 broadly sensitizes wild-type and mutant PTEN glioblastoma cells to both death receptor and chemotherapy-induced apoptosis
LY294002
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simultaneous inhibition of the mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase pathways enhances sensitivity to paclitaxel in ovarian carcinoma
LY294002
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the inhibitor markedly suppresses phosphorylation of Akt and accelerates TRAIL-mediated apoptosis in oral squamous cell carcinoma cell
LY294002
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inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins
LY294002
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the specific inhibitor of the phosphatidylinositol 3-kinase upregulates beta1,4-galactosyltransferase I and thus sensitizes SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma
LY294002
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i.e. [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]
LY294002
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specific PI3K inhibitor, effects of LY294002 on Kv1.5 channels, wild-type and mutant, are independent of the effects on PI3K activity, overview
LY294002
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acts synergistically with the leukotriene biosynthesis inhibitor MK591, overview
LY294002
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a potent inhibitor of PI3-kinase, significantly inhibits phosphorylation of both p85 and ERK1/2 in vivo
LY294002
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specific PI3K inhibitor, restores vasorelaxation and hyperpolarization in response to an ATP-sensitive K+ channel opener levcromakalim
LY294002
inhibits wild-type activity in vitro almost as efficiently as KU55933, but is required at much higher concentrations for efficient inhibition of autophagy
LY294002
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specific inhibitor
LY294002
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specific inhibition
LY294002
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preclinical evidence for the in vivo efficacy for LY294002 in the treatment of follicular thyroid cancer
LY294002
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significantly inhibits retinal neovascularization in a mouse model of retinal neovascularization
LY294002
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a PI3K antagonist
LY294002
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application inhibits rice seed germination and the expression of NADPK oxidase
LY294002
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specific inhibition
LY294002
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the inhibitor potently, reversibly blocks voltage-dependent K+ channel currents via a direct mechanism, IC50 is 0.009 mM, potentiates glucose-stimulated insulin secretion from MIN6 cells in vivo
LY294002
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inhibition of PI3-kinase induces apoptotic cell death, which is mediated by inactivation of Akt pathway in rat osteoblasts
LY294002
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may modulate function of the glycine transporters GlyT1 independent of PI3 kinase inhibition
LY294002
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a specific inhibitor of PI3K, effectively suppresses the microglia-derived plasminogen-dependent phosphorylation of Akt
LY294002
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i.e. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a potent PI3K inhibitor, in vitro and vivo inhibition. Spinal application of LY294002 reduces the wind-up of deep dorsal WDR neurons and inhibits electrically evoked responses. Electrically evoked substance P release is not inhibited by LY294002
LY294002
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IC50 values: 2 mM
LY294002
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inhibits sperm-induced activation of the tyrosine kinase Src and a transient increase in the intracellular concentration of Ca2+ at fertilization. LY294002 also has an inhibitory effect on the Ca2+-dependent breakdown of the Mos protein kinase and cyclin B2 as well as dephosphorylation of mitogenactivated protein kinase
LY301497
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Nonidet P40
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NVP-BEZ235
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the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin catalytic inhibitor, interferes with tumor growth likely by affecting tumor cells and their vasculature system
NVP-BEZ235
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potency and selectivity for efficient P13K pathway blockade, potent in vivo antitumor activity
NVP-BEZ235
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a mTOR/phosphatidylinositol 3-kinase inhibitor. Effector lapatinib and the PI3K inhibitor NVP-BEZ235 collaborate to suppress the PI3K-AKT-mTOR axis driven by loss-offunction PTEN mutations, overview
phosphatidylcholine
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strong inhibition of enzyme form PI3KII, weak inhibition of enzyme form PI3KI
PWT-458
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i.e. poly(oxy-1,2-ethanediyl)-, R-[2-[[2-[[(1S,6bR,9S,9aS,11R,11bR)-11-(acetyloxy)-1,6,6b,7,8,9,9a,10,11,11b-decahydro-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-3Hfuro[4,3,2-de]indeno[4,5-h]-2-benzopyran-9-yl]oxy]-2-oxoethyl]thio]ethyl]-omega-methoxy
PWT-458
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i.e. poly(oxy-1,2-ethanediyl)-, R-[2-[[2-[[(1S,6bR,9S,9aS,11R,11bR)-11-(acetyloxy)-1,6,6b,7,8,9,9a,10,11,11b-decahydro-1-(methoxymethyl)-9a,11b-dimethyl-3,6-dioxo-3Hfuro[4,3,2-de]indeno[4,5-h]-2-benzopyran-9-yl]oxy]-2-oxoethyl]thio]ethyl]-omega-methoxy
PX-866
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potent inhibitor of cancer cell motility and growth in three-dimensional cultures
PX-866
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i.e. acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxacyclopenta[a]phenanthren-11-yl ester
PX-866
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i.e. acetic acid 4-diallylaminomethylene-6-hydroxy-1-alpha-methoxymethyl-10beta,13beta-dimethyl-3,7,17-trioxo-1,3,4,7,10,11beta,12,13,14alpha,15,16,17-dodecahydro-2-oxacyclopenta[a]phenanthren-11-yl ester
quercetin
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inhibition of PI 3-kinase I and II; PI 3-kinase I and PI 3-kinase II, non-competitive
quercetin
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5 mM, 70% inhibition
Wortmannin
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Wortmannin
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inhibition is of a noncompetitive type with regard to ATP, observed with phosphatidylinositol, phosphatidylinositol monophosphate, or phosphatidylinositol bisphosphate as substrate
Wortmannin
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PI3K-C2a is refractory to
Wortmannin
at nanomolar levels
Wortmannin
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phosphoinositide 3-kinase with a C2 domain displays reduced sensitivity to the inhibitor wortmannin
Wortmannin
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inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
Wortmannin
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the inhibitor markedly suppresses phosphorylation of Akt and accelerates TRAIL-mediated apoptosis in oral squamous cell carcinoma cell
Wortmannin
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inhibition of PI 3-K enhances the susceptibility of oral squamous cell carcinoma cells to anticancer drug-mediated apoptosis through regulation of expression and post-translational modification of both pro- and antiapoptotic proteins
Wortmannin
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the specific inhibitor of the phosphatidylinositol 3-kinase upregulates beta1,4-galactosyltransferase I and thus sensitizes SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. PI3K inhibitors might have therapeutic potential when combined with cycloheximide in the treatment of hepatoma
Wortmannin
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an irreversible inhibitor with pan-PI3K activity
Wortmannin
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treatment with wortmannin results in sustained reduction of phosphatidylinositol 3-phosphate and a transient effect on production of phosphatidylinositol 3,4,5-trisphosphate with recovery after 9 h
Wortmannin
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specific inhibitor
Wortmannin
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specific irreversible inhibition, binds covalently to the active site, mixed type inhibition, IC50 is 12 nM
Wortmannin
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a PI3K antagonist
Wortmannin
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an irreversible inhibitor with pan-PI3K activity
Wortmannin
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treatment with wortmannin results in sustained reduction of phosphatidylinositol 3-phosphate and a transient effect on production of phosphatidylinositol 3,4,5-trisphosphate with recovery after 9 h
Wortmannin
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application inhibits rice seed germination and the expression of NADPK oxidase
Wortmannin
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specific inhibition, no blockage of whole-cell outward K+ currents
Wortmannin
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a specific PI 3-K inhibitor
Wortmannin
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intracerebroventricular injection of leptin significantly increases phosphodiesterase 3B activity by twofold in the hypothalamus. Previous administration of wortmannin, a specific PI3K inhibitor, completely reverses the stimulatory effect of leptin on phosphodiesterase 3B activity in the hypothalamus
additional information
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chelation of intracellular Ca2+
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additional information
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LY303511, i.e. 2-(4-Piperazinyl)-8-phenyl-4H-1-benzopyran-4-one, is an inactive analogue of LY294002
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additional information
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no inhibition by resveratrol, i.e. 3,4',5-trihydroxystilbene, which is an inhibitor of type II phosphatidylinositol 4-kinase
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additional information
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tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling
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additional information
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MK591 does not inhibit PI3K
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additional information
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small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/beta-catenin pathway cross-talk and suppress medulloblastoma growth. The inhibitors affect beta-catenin signaling by inhibition of GSK-3beta activity, resulting in cytoplasmic retention of beta-catenin and reduced expression of its target genes cyclin D1 and c-Myc
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additional information
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drug design and synthesis, 17-hydroxywortmannin analogues conjugated to rapamycin analogues via a prodrug linker , inhibitory potency, overview
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additional information
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the PI3K-related kinase proteins share significant sequence homology with PI3K, therefore drugs targeting PI3K may also inhibit PI3K-related kinase, PIKK, activity
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additional information
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downstream lipid products affect the enzyme activity via effectors
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additional information
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no inhibition by 5,6-dichlorobenzimidazole
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additional information
inhibition of TcVps34 with specific PI3K inhibitors, such as wortmannin and LY294000, result in reduced regulatory volume decrease after hyposmotic stress
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additional information
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inhibition of TcVps34 with specific PI3K inhibitors, such as wortmannin and LY294000, result in reduced regulatory volume decrease after hyposmotic stress
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