2.7.1.105: 6-phosphofructo-2-kinase

This is an abbreviated version!
For detailed information about 6-phosphofructo-2-kinase, go to the full flat file.

Reaction

Synonyms

6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2, 6-phosphofructo kinase-2/fructose diphosphatase-2 isoenzyme 3, 6-phosphofructo-2-kinase, 6-phosphofructo-2-kinase/2,6-bisphosphatase 3, 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase:glucokinase complex, 6-phosphofructose 2-kinase, 6PF2K/Fru-2,6-P2ase, ATP:D-fructose-6-phosphate 2-phosphotransferase, fructose 6-phosphate 2-kinase, inducible 6-phosphofructo-2-kinase, iPFK2, kinase, 6-phosphofructo-2-(phosphorylating), OsF2KP1, OsF2KP2, Pfk-2, PFK-2/FBPase, PFK-2/FBPase-2, PFK2, PFK2/FBPase2, PFKFB, PFKFB-3, PFKFB1, PFKFB2, PFKFB3, PFKFB4, phosphofructokinase 2, phosphofructokinase-2, phosphofructokinase-2/fructose bisphosphatase-2, T-PFK2, tPFK-2, uPFK-2

ECTree

     2 Transferases

         2.7 Transferring phosphorus-containing groups

             2.7.1 Phosphotransferases with an alcohol group as acceptor

                2.7.1.105 6-phosphofructo-2-kinase

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Results	in table
11	Activating Compound
192	AA Sequence
18	Application
1	CAS Registry Number
56	Cloned(Commentary)
30	Cofactor
9	Crystallization (Commentary)
109	Disease/ Diagnostics
18	Expression
57	General Information
3	General Stability
24	IC50 Value
215	Inhibitors
75	Ki Value [mM]
189	KM Value [mM]
14	Localization
86	Metals/Ions
72	Molecular Weight [Da]
74	Natural Substrates/ Products (Substrates)
173	Organism
3	Pathway
33	PDB ID
32	pH Optimum
10	pH Range
3	pI Value
84	Posttranslational Modification
63	Protein Variants
54	Purification (Commentary)
60	Reaction
1	Reaction Type
158	Reference
1	Renatured (Commentary)
283	Source Tissue
48	Specific Activity [micromol/min/mg]
6	Storage Stability
265	Substrates and Products (Substrate)
60	Subunits
146	Synonyms
1	Systematic Name
45	Temperature Optimum [°C]
4	Temperature Stability [°C]
43	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.7.1.105 - 6-phosphofructo-2-kinase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.026

(2E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

1

2-((5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)amino)acetamide

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.5

2-(5-bromo-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)-1,2,3,4-tetrahydroisoquinoline-5-carbonitrile

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.027

2-hydroxy-4-[(naphthalen-1-ylsulfonyl)amino]benzoic acid

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

1

3H-benzo[e]indol-2-yl(pyridin-4-yl)methanone

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0084

4-(4-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-5-bromo-6-oxopyridazin-1(6H)-yl)benzonitrile

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

1

4-bromo-2-phenyl-5-(((tetrahydrofuran-2-yl)methyl)amino)pyridazin-3(2H)-one

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

1

4-bromo-2-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyridazin-3(2H)-one

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

1

4-bromo-5-morpholino-2-phenylpyridazin-3(2H)-one

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0034

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzyl-4-bromopyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

10

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-2-benzylpyridazin-3(2H)-one

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.011

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(3-phenylpropyl)pyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.5

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-((2-(dimethylamino)ethyl)-amino)benzyl)pyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0091

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-(trifluoromethoxy)phenyl)-pyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.007

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-chlorophenyl)pyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0087

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(4-iodobenzyl)pyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0096

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-(pyrimidin-5-yl)pyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0026

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenethylpyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.0074

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-bromo-2-phenylpyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.026

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-chloro-2-phenylpyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

1

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-ethoxy-2-phenylpyridazin-3(2H)-one

Homo sapiens

Q16875

above, pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.013

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-iodo-2-phenylpyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.5

5-(4-acetyl-5-methyl-1H-1,2,3-triazol-1-yl)-4-isopropyl-2-phenylpyridazin-3(2H)-one

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389

0.055

ethyl 1-(6-oxo-1-phenyl-5-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1,6-dihydropyridazin-4-yl)-1H-1,2,3-triazole-4-carboxylate

Homo sapiens

Q16875

pH 7.5, 30°C, recombinant GST-tagged enzyme

729389