2.6.1.45: serine-glyoxylate transaminase

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For detailed information about serine-glyoxylate transaminase, go to the full flat file.

Reaction

Synonyms

AGT1, alanine:glyoxylate aminotransferase, aminotransferase, serine-glyoxylate, FpSGAT, L-serine glyoxylate aminotransferase, More, Os08g0502700, serine-alpha-ketoglutarate aminotransferase, serine-glyoxylate aminotranferase, serine-glyoxylate aminotransferase, serine:glyoxylate aminotransferase, serine:glyoxylate transaminase, Sga, Sga20Z, SgaBath, SGAT, SGT, SKAT

ECTree

     2 Transferases

         2.6 Transferring nitrogenous groups

             2.6.1 Transaminases

                2.6.1.45 serine-glyoxylate transaminase

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Results	in table
743	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
18	Cofactor
1	Crystallization (Commentary)
303	Disease/ Diagnostics
1	Expression
57	General Information
2	General Stability
58	Inhibitors
12	Ki Value [mM]
69	KM Value [mM]
12	Localization
24	Molecular Weight [Da]
52	Natural Substrates/ Products (Substrates)
63	Organism
13	Pathway
4	PDB ID
11	pH Optimum
4	pH Range
5	pH Stability
9	Protein Variants
15	Purification (Commentary)
8	Reaction
1	Reaction Type
48	Reference
17	Source Tissue
8	Specific Activity [micromol/min/mg]
4	Storage Stability
122	Substrates and Products (Substrate)
22	Subunits
81	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
5	Temperature Stability [°C]
5	Turnover Number [1/s]

Engineering

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Engineering on EC 2.6.1.45 - serine-glyoxylate transaminase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

P251L

Arabidopsis thaliana

Q56YA5

the sat mutation likely affects the dimer interface near the catalytic site, phenotype overview. The point mutation renders the sat mutant plants lethally stunted when grown in normal atmospheric conditions

759257

additional information

8 entries

additional information

Arabidopsis thaliana

Q56YA5

transgenic overexpression of Flaveria pringlei SGAT in Arabidopsis thaliana rosette leaves via transfection with Agrobacterium tumefaciens strain GV3101, quantitative RT-PCR enzyme expression analysis

759565

additional information

Arabidopsis thaliana Col-0

-

transgenic overexpression of Flaveria pringlei SGAT in Arabidopsis thaliana rosette leaves via transfection with Agrobacterium tumefaciens strain GV3101, quantitative RT-PCR enzyme expression analysis

-

additional information

Flaveria pringlei

-

elevated SGAT activity through transgenic overexpression of Flaveria pringlei SGAT causes clear changes in metabolism and interferes with photosynthetic CO2 uptake and biomass accumulation of Arabidopsis thaliana. The faster serine turnover during photorespiration progressively lowers day-time leaf serine contents and in turn induces the phosphoserine pathway. Transcriptional upregulation of this additional route of serine biosynthesis occurs already during the day but particularly at night, efficiently counteracting night-time serine depletion. Additionally, higher SGAT activity results in an increased use of asparagine as the external donor of amino groups to the photorespiratory pathway but does not alter leaf asparagine content at night. Phenotype, detailed overview

759565

additional information

Methylotuvimicrobium alcaliphilum

G4T3S7

the sga20Z gene is knocked out by the insertion of the kanamycin cassette using double homologous recombination. The growth rate of the DELTAsga strain on methane is significantly lower as compared to the wild-type strain. During growth on methanol, this effect is even more pronounced

758661

additional information

Methylotuvimicrobium alcaliphilum 20Z

-

the sga20Z gene is knocked out by the insertion of the kanamycin cassette using double homologous recombination. The growth rate of the DELTAsga strain on methane is significantly lower as compared to the wild-type strain. During growth on methanol, this effect is even more pronounced

-

additional information

Methylotuvimicrobium alcaliphilum DSM 19304

-

the sga20Z gene is knocked out by the insertion of the kanamycin cassette using double homologous recombination. The growth rate of the DELTAsga strain on methane is significantly lower as compared to the wild-type strain. During growth on methanol, this effect is even more pronounced

-

additional information

Methylotuvimicrobium alcaliphilum NCIMB 14124

-

the sga20Z gene is knocked out by the insertion of the kanamycin cassette using double homologous recombination. The growth rate of the DELTAsga strain on methane is significantly lower as compared to the wild-type strain. During growth on methanol, this effect is even more pronounced

-

additional information

Methylotuvimicrobium alcaliphilum VKM B-2133

-

the sga20Z gene is knocked out by the insertion of the kanamycin cassette using double homologous recombination. The growth rate of the DELTAsga strain on methane is significantly lower as compared to the wild-type strain. During growth on methanol, this effect is even more pronounced

-