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2.6.1.36: L-lysine 6-transaminase

This is an abbreviated version!
For detailed information about L-lysine 6-transaminase, go to the full flat file.

Word Map on EC 2.6.1.36

Reaction

L-lysine
+
2-oxoglutarate
=
(S)-2-amino-6-oxohexanoate
 +
L-glutamate

Synonyms

aminotransferase, lysine 6-, EC 2.6.1.68, L-lysine-alpha-ketoglutarate 6-aminotransferase, L-lysine-alpha-ketoglutarate aminotransferase, L-lysine-epsilon-aminotransferase, LAT, lysine 6-aminotransferase, lysine epsilon-aminotransferase, lysine epsilon-transaminase, lysine-epsilon-aminotransferase, lysine:2-ketoglutarate 6-aminotransferase, Rv3290c

ECTree

     2 Transferases
         2.6 Transferring nitrogenous groups
             2.6.1 Transaminases
                2.6.1.36 L-lysine 6-transaminase

Inhibitors

Inhibitors on EC 2.6.1.36 - L-lysine 6-transaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-2-(2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid
-
(E)-2-(4-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)phenoxy)acetic acid
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-indol-3-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(1H-pyrrol -2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(2,4-dihydroxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4,5-trimethoxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(3,4-dimethoxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-benzyloxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-fluorophenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(4-hydroxyphenyl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrofuran-2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(5-nitrothiophen-2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(furan-2-yl)acrylonitrile
-
(E)-2-(benzo[d]thiazol-2-yl)-3-(thiophen-2-yl)acrylonitrile
-
(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid
-
(E)-3-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
-
(E)-3-(benzo[d][1,3]dioxol-5-yl)-2-(benzo[d]thiazol-2-yl)acrylonitrile
-
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)benzoic acid
-
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)benzoic acid
-
(E)-4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)isophthalic acid
-
(E)-5-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)furan-2-yl)isophthalic acid
-
2,2'-oxybis[N'-[(E)-(4-fluorophenyl)methylidene]acetohydrazide]
25.6% cytotoxicity at 0.1 mM
2,2'-oxybis[N'-[(E)-[(3-benzyloxy)phenyl]methylidene]acetohydrazide]
26.4% cytotoxicity at 0.1 mM
2-oxopentanedioic acid
binding energy 6.48 kcal per mol
2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
-
2-[methyl[(1-methylpiperidin-2-yl)methyl]amino]-1-phenylethanol
binding energy 7.23 kcal per mol
4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide
protein is stabilzed in presence of the inhibitor
4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
at 0.05 mM, 24.87% cytotoxicity in a HEK-293 cell line
5-Aminopentanoate
-
-
5-hydroxylysine
-
DL-
acetate
-
stimulates alanine transamination, inhibits lysine transamination
Br-
-
stimulates alanine transamination, inhibits lysine transamination
Cl-
-
stimulates alanine transamination, inhibits lysine transamination
F-
-
stimulates alanine transamination, inhibits lysine transamination
formate
-
stimulates alanine transamination, inhibits lysine transamination
I-
-
stimulates alanine transamination, inhibits lysine transamination
N-([2-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-dioxo-2,3,5,6,11,11a-hexahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indol-5-yl]methyl)-2-(4-methoxyphenyl)acetamide
binding energy 10.79 kcal per mol
O-(2-aminoethyl)-DL serine
-
-
Phenylglyoxal
-
loss of activity with lysine, no effect on activity with L-alanine
propionate
-
inhibits alanine transamination and lysine transamination
additional information
-