Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.5.1.15: dihydropteroate synthase

This is an abbreviated version!
For detailed information about dihydropteroate synthase, go to the full flat file.

Word Map on EC 2.5.1.15

Reaction

(7,8-dihydropterin-6-yl)methyl diphosphate
+
4-Aminobenzoate
=
diphosphate
 +
7,8-dihydropteroate

Synonyms

6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropterin-pyrophosphokinase-dihydropteroate synthase, 6-hydroxymethyl-7,8-dihydropteroate synthase, 7,8-dihydropteroate synthase, 7,8-dihydropteroate synthetase, 7,8-dihydropteroic acid synthetase, BCG3672c, DHP synthase, DHPS, DHPS-HPPK, DHPS/DHPR, dihydroneopterin aldolase-dihydropterin pyrophosphokinase-dihydropteroate synthase, dihydropteroate diphosphorylase, dihydropteroate synthase, dihydropteroate synthase/hydroxymethyldihydropterin pyrophosphokinase, dihydropteroate synthetase, dihydropteroic synthetase, FolP, folP1, folP2, HPPK-DHPS, hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, MbDHPS, MtDHPS, Mycobacterium tuberculosis dihydropteroate synthase, PfDHPS, pfPPK-DHPS, PPPK-DHPS, putative dihydropteroate synthase ortholog, pvdhps, PvHPPK-DHPS, PVX_123230, Rv1207, synthase, dihydropteroate

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.15 dihydropteroate synthase

Substrates Products

Substrates Products on EC 2.5.1.15 - dihydropteroate synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
7,8-dihydropteroate + diphosphate
show the reaction diagram
-
-
-
?
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + 4-aminobenzoate
7,8-dihydropteroate + diphosphate
show the reaction diagram
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoylglutamate
diphosphate + dihydrofolate
show the reaction diagram
-
-
-
?
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfamethoxazole
diphosphate + dihydropterin-sulfamethoxazole
show the reaction diagram
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfanilamide
diphosphate + dihydropterin-sulfanilamide
show the reaction diagram
-
-
-
?
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + sulfathiazole
diphosphate + dihydropterin-sulfathiazole
show the reaction diagram
4-aminobenzoate + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
dapson + Mg-6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 2-amino-6-[([4-[(4-aminophenyl)sulfonyl]phenyl]amino)methyl]-7,8-dihydropteridin-4(3H)-one
show the reaction diagram
-
-
-
?
p-aminobenzoate + 6-hydroxymethyl-7,8-dihydropterin-diphosphate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
p-aminobenzoic acid + 6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 7,8-dihydropteroate
show the reaction diagram
substrate binding order: 6-hydroxymethyl-7,8-dihydropterin diphosphate binds prior to p-aminobenzoic acid, 6-hydroxymethyl-7,8-dihydropterin diphosphate binding with KD: 33 +/-6 microM (k(on): 260000 1/M*s, k(off): 8.7 1/s) as revealed by fluorescence spectroscopy, p-aminobenzoic acid binding to diphosphate-enzyme complex: KD: 0.13 +/-0.02 microM
diphosphate-binding allows binding of p-aminobenzoic acid or p-aminobenzoic acid analogues, diphosphate binding with KD: 350 +/-20 microM (k(on): 56000 1/M*s, k(off): 21 1/s) as revealed by fluorescence spectroscopy
-
?
sulfadiazine + 6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-pyrimidin-2-ylbenzenesulfonamide
show the reaction diagram
-
-
-
?
sulfamethizole + 6-hydroxymethyl-7,8-dihydropterin diphosphate
?
show the reaction diagram
-
-
-
?
sulfamethizole + 6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide
show the reaction diagram
-
-
-
?
sulfamethoxazole + 6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-(5-methylisoxazol-3-yl)benzenesulfonamide
show the reaction diagram
-
-
-
?
sulfanilamide + 6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]benzenesulfonamide
show the reaction diagram
-
-
-
?
sulfathiazole + 6-hydroxymethyl-7,8-dihydropterin diphosphate
diphosphate + 4-[[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino]-N-1,3-thiazol-2-ylbenzenesulfonamide
show the reaction diagram
-
-
-
?
sulfisoxazole + 6-hydroxymethyl-7,8-dihydropterin diphosphate
?
show the reaction diagram
-
-
-
?
additional information
?
-