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2.5.1.113: [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

This is an abbreviated version!
For detailed information about [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase, go to the full flat file.

Word Map on EC 2.5.1.113

Reaction

O-phospho-L-serine
+
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)SH
=
[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-cysteine
+
phosphate

Synonyms

CysM, Cysteine synthase, O-phosphoserine sulfhydrylase, O-phosphoserine-specific cysteine synthase, Rv1336

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.113 [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

Systematic Name

Systematic Name on EC 2.5.1.113 - [CysO sulfur-carrier protein]-thiocarboxylate-dependent cysteine synthase

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SYSTEMATIC NAME
IUBMB Comments
O-phospho-L-serine:thiocarboxylated [CysO sulfur-carrier protein] 2-amino-2-carboxyethyltransferase
A pyridoxal-phosphate protein. The enzyme participates in an alternative pathway for L-cysteine biosynthesis that involves a protein-bound thiocarboxylate as the sulfide donor. The enzyme from the bacterium Mycobacterium tuberculosis also has very low activity with O3-acetyl-L-serine (cf. EC 2.5.1.65, O-phosphoserine sulfhydrylase).