2.5.1.104: N1-aminopropylagmatine synthase

This is an abbreviated version!
For detailed information about N1-aminopropylagmatine synthase, go to the full flat file.

Reaction

Synonyms

ACAPT, agmatine aminopropyltransferase, agmatine/cadaverine aminopropyl transferase, PF0127, SpeE, TAAPT, TK0147 protein, triamine/agmatine aminopropyltransferase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.104 N1-aminopropylagmatine synthase

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Results	in table
29	AA Sequence
4	Cloned(Commentary)
2	Crystallization (Commentary)
13	kcat/KM [mM/s]
13	KM Value [mM]
6	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
4	Organism
3	Pathway
6	pH Optimum
1	pH Stability
4	Purification (Commentary)
1	Reaction
4	Reference
1	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
4	Subunits
9	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
13	Turnover Number [1/s]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 2.5.1.104 - N1-aminopropylagmatine synthase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagamatine

Thermococcus kodakarensis

Q5JFG9

the enzyme is involved in polyamine biosynthesis

719718

-

-

?

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine

5 entries

S-adenosyl 3-(methylthio)propylamine + agmatine

S-methyl-5'-thioadenosine + N1-aminopropylagmatine

Thermus thermophilus

Q5SK28

-

720250

-

-

?

S-adenosyl 3-(methylthio)propylamine + cadaverine

5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine

3 entries

S-adenosyl 3-(methylthio)propylamine + homospermidine

S-methyl-5'-thioadenosine + ?

Thermus thermophilus

Q5SK28

low activity

720250

-

-

?

S-adenosyl 3-(methylthio)propylamine + N,N'-bis(3-aminopropyl)-1,3-propanediamine

S-methyl-5'-thioadenosine + ?

Thermus thermophilus

Q5SK28

i.e. thermine. Low activity

720250

-

-

?

S-adenosyl 3-(methylthio)propylamine + norspermidine

S-methyl-5'-thioadenosine + N,N'-bis(3-aminopropyl)-1,3-propanediamine

Thermus thermophilus

Q5SK28

-

720250

i.e. thermine

-

?

S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine

5'-S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine

Pyrococcus furiosus

Q8U4G1

2.9% of the activity compared to cadaverine

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + putrescine

5'-S-methyl-5'-thioadenosine + spermidine

2 entries

S-adenosyl 3-(methylthio)propylamine + spermidine

5'-S-methyl-5'-thioadenosine + spermine

Pyrococcus furiosus

Q8U4G1

0.8% of the activity compared to cadaverine

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + spermidine

S-methyl-5'-thioadenosine + spermine

Thermus thermophilus

Q5SK28

-

720250

no formation of thermospermine (i.e. 1,12-diamino-4,8-diazadodecane)

-

?

S-adenosyl 3-(methylthio)propylamine + tris(3-aminopropyl)amine

S-methyl-5'-thioadenosine + N4-aminopropylthermine

Thermus thermophilus

Q5SK28

i.e. mitsubishine. Low activity. No formation of tetrakis(3-aminopropyl)ammonium

720250

-

-

?

additional information

?

-

2 entries

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine

Pyrococcus furiosus

Q8U4G1

agmatine is the physiological substrate in the constitutive synthesis of spermidine, while cadaverine acts as an aminopropyl acceptor under stress conditions when an active and rapid synthesis of N-(3-aminopropyl)cadaverine could be required

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine

Pyrococcus furiosus

Q8U4G1

4.9% of the activity compared to cadaverine

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine

Thermococcus kodakarensis

Q5JFG9

-

719718

-

-

?

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine

Thermus thermophilus

Q5SK28

-

719832

-

-

?

S-adenosyl 3-(methylthio)propylamine + agmatine

5'-S-methyl-5'-thioadenosine + N1-aminopropylagmatine

Thermus thermophilus

Q5SK28

the enzyme is involved in polyamine biosynthesis

719832

-

-

?

S-adenosyl 3-(methylthio)propylamine + cadaverine

5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine

Pyrococcus furiosus

Q8U4G1

-

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + cadaverine

5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine

Pyrococcus furiosus

Q8U4G1

agmatine is the physiological substrate in the constitutive synthesis of spermidine, while cadaverine acts as an aminopropyl acceptor under stress conditions when an active and rapid synthesis of N-(3-aminopropyl)cadaverine could be required

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + cadaverine

5'-S-methyl-5'-thioadenosine + N-(3-aminopropyl)cadaverine

Thermococcus kodakarensis

Q5JFG9

-

719718

-

-

?

S-adenosyl 3-(methylthio)propylamine + putrescine

5'-S-methyl-5'-thioadenosine + spermidine

Pyrococcus furiosus

Q8U4G1

8.7% of the activity compared to cadaverine

719710

-

-

?

S-adenosyl 3-(methylthio)propylamine + putrescine

5'-S-methyl-5'-thioadenosine + spermidine

Thermococcus kodakarensis

Q5JFG9

-

719718

-

-

?

additional information

?

-

Thermus thermophilus

Q5SK28

only faint activities (less than 10% of spermidine) are detected for diaminopropane [NH2(CH2)3NH2], putrescine, spermine, and caldopentamine

720250

-

-

?

additional information

?

-

Thermus thermophilus

-

only faint activities (less than 10% of spermidine) are detected for diaminopropane [NH2(CH2)3NH2], putrescine, spermine, and caldopentamine

720250

-

-

?