2.4.2.52: triphosphoribosyl-dephospho-CoA synthase

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2'-(5-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA

Synonyms

2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase, ATP:dephospho-CoA 5-triphosphoribosyl transferase, CitG, EC 2.7.8.25, MdcB, synthetase, 2'-(5''-triphosphoribosyl)-3'-dephospho-coenzyme A, triphosphoribosyldephospho-CoA synthase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.52 triphosphoribosyl-dephospho-CoA synthase

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Results	in table
9815	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	Expression
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
8	Organism
2	Pathway
1	Purification (Commentary)
2	Reaction
2	Reaction Type
6	Reference
1	Storage Stability
8	Substrates and Products (Substrate)
1	Subunits
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.2.52 - triphosphoribosyl-dephospho-CoA synthase

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ATP:3'-dephospho-CoA 5-triphospho-alpha-D-ribosyltransferase

ATP cannot be replaced by GTP, CTP, UTP, ADP or AMP. The reaction involves the formation of a new alpha (1''->2') glycosidic bond between the two ribosyl moieties, with concomitant displacement of the adenine moiety of ATP [1,4]. The 2'-(5-triphosphoribosyl)-3'-dephospho-CoA produced can be transferred by EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase, to the apo-acyl-carrier protein subunit (gamma-subunit) of EC 4.1.3.6, citrate (pro-3S) lyase, thus converting it from an apo-enzyme into a holo-enzyme [1,3]. Alternatively, it can be transferred to the apo-ACP subunit of malonate decarboxylase by the action of EC 2.7.7.66, malonate decarboxylase holo-[acyl-carrier protein] synthase [4].