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5-fluorouracil + 2-deoxy-alpha-D-ribose 1-phosphate
5-fluoro-2'-deoxyuridine + phosphate
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the enzyme converts 5-fluorouracil to 5-fluoro-2'-deoxyuridine, activating the prodrug, overview. This action can only take place if there is enough co-substrate. 5-Fluorouracil prodrugs and metabolism, detailed overview
5-fluoro-2'-deoxyuridine is further converted by thymidine kinase to 5-fluoro-2'-deoxyuridine 5'-monophosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
uracil + 2-deoxy-alpha-D-ribose 1-phosphate
2'-deoxyuridine + phosphate
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additional information
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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2-deoxy-alpha-D-ribose 1-phosphate strongly promoted neovascularization
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-alpha-D-ribose 1-phosphate
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thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
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intact platelets degrade thymidine but are not able to synthesize thymidine from thymine
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thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
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the enzyme confers resistance to apoptosis induced by hypoxia. The enzymatic degradation of thymidine by thymidine phosphorylase is required for the inhibition of hypoxia-induced apoptosis. The enzyme can confer resistance to apoptosis in addition to its angiogenic activity. The enzyme must play some role in the development or malignancy of tumors. Involved in invasion and metastasis of some solid tumors
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thymidine + phosphate
thymine + 2-deoxy-D-ribose 1-phosphate
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the enzyme plays a crucial role in intratumoral angiogenesis, which occurs in the early phase of ovarian cancer, or influences angiogenesis indirectly
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thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-alpha-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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enzyme is enantioselective, acts only on the naturally occurring D-thymidine and some D-thymidine analogs, but not on their L-counterparts
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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degradation of uridine in tumor specimen
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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enzyme also catalyzes the nucleoside deoxyribosyltransferase reaction with pyrimidine deoxyribonucleosides, ec2.4.2.6
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thymine + 2-deoxy-D-ribose 1-phosphate
thymidine + phosphate
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in Escherichia coli and Salmonella typhimurium thymidine phosphorylase plays an important role in metabolism of thymine auxotrophs and is necessary for the conversion of exogenous thymine to thymidine
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role in thymidine metabolism, homeostasis, development and regeneration of central nervous system and formation of blood/brain barrier
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formation of blood/brain barrier and repair following brain injury
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identical to platelet-derived endothelial cell growth factor
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identical to platelet-derived endothelial cell growth factor
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mitogenic effect, promotes endothelial cell proliferation
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angiogenic activity
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angiogenic activity
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angiogenic activity
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angiogenic activity
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angiogenic activity
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angiogenic activity
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expression of PD-ECGF/TP may play an important role in the progression of solid tumors
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important role in nucleoside metabolism, implicated in angiogenesis and apoptosis
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important role in nucleoside metabolism, implicated in angiogenesis and apoptosis
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thymidine phosphorylase and uridine phosphorylase contribute in the conversion of 5'-deoxy-5-fluorouridine into 5-fluorouracil and the conversion of 5-fluorouracil into its active metabolites in peripheral blood mononuclear cell, but thymidine phosphorylase seems to be the most important enzyme for these reactions in PBMC
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the enzyme stimulates formation of focal adhesions and the phosphorylation of Tyr397 of focal adhesion kinase, and it induces the expression and/or secretion of other angiogenic factors, overview. Thymidine phosphorylase promotes tumor growth and metastasis by preventing apoptosis and inducing angiogenesis, detailed overview. As gliostatin from fibroma cells, the enzyme inhibits the growth of both astrocytes and glial tumor cells
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thymidine phosphorylase is identical with platelet-derived endothelial cell growth factor, PD-ECGF, which promotes angiogenesis. The mechanism of endometrial angiogenesis involves thymidine phosphorylase and stimulation by ovarian steroids of production of angiogenic regulators by endometrial epithelium and stroma which then act on the endothelium
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