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2.4.2.36: NAD+-diphthamide ADP-ribosyltransferase

This is an abbreviated version!
For detailed information about NAD+-diphthamide ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.36

Reaction

NAD+
+
diphthamide-[translation elongation factor 2]
=
nicotinamide
 +
N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2, ADP-ribosyltransferase, cholera toxin, cholix, cholix toxin, chxA, CTB, diphthamide-specific ADPRT, diphthamide-specific mono-ADP-ribosylating toxin, EHI 155600, EhToxin-l, EhToxin-like, ExoA, ExoA(c), exotoxin A, mono(ADPribosyl)transferase, mono-ADP-ribosyltransferase, NAD(+)-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase NAD-elongation factor 2 ADP-ribosyltransferase, NAD:elongation factor 2-adenosine diphosphate ribose-transferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.36 NAD+-diphthamide ADP-ribosyltransferase

Inhibitors

Inhibitors on EC 2.4.2.36 - NAD+-diphthamide ADP-ribosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,8-naphthalimide
-
potent competitive
1H-benzo[de]isoquinoline-1,3(2H)-dione
-
2-[(5,6-dimethyl-4-oxo-3,4,4a,7a-tetrahydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-(2-hydroxyethyl)acetamide
-
3-((3,3-diethylguanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 24% inhibition
3-((3,3-diisopropylguanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 94% inhibition
3-((3-(1-benzylpiperidin-4-yl)guanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 96% inhibition
3-((3-(1-benzylpyrrolidin-3-yl)guanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 68% inhibition
3-((3-(2-(ethyl(m-tolyl)amino)ethyl)guanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 76% inhibition
3-((3-(2-morpholinoethyl)guanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 57% inhibition
3-((3-(4-bromobenzyl)guanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 98% inhibition
3-((3-(4-methoxybenzyl)guanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 97% inhibition, not sufficient material for IC50 and Ki estimation
3-((3-benzylguanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 93% inhibition
3-((3-phenethylguanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 93% inhibition
3-((3-phenylguanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 57% inhibition
3-((3-tert-butylguanidino)methyl)benzamide
-
1 mM, 37°C, pH 7, 39% inhibition
3-(3,3-diisopropylguanidino)benzamide
-
1 mM, 37°C, pH 7, 15% inhibition
3-(3-(1-benzylpiperidin-4-yl)guanidino)benzamide
-
1 mM, 37°C, pH 7, 58% inhibition
3-(3-(4-bromobenzyl)guanidino)benzamide
-
1 mM, 37°C, pH 7, 22% inhibition
3-(3-benzylguanidino)benzamide
-
1 mM, 37°C, pH 7, 10% inhibition
3-(3-phenylguanidino)benzamide
-
1 mM, 37°C, pH 7, 12% inhibition
3-(3-tert-butylguanidino)benzamide
-
1 mM, 37°C, pH 7, 77% inhibition
4-amino-1,8-naphthalimide
-
-
8-fluoro-2-[3-(piperidin-1-yl)propanoyl]-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one
-
Cytoplasmic extract of pyBHK-cells
-
not fragment A
-
Elastase
-
inactivation follows pseudo-first order kinetic
-
ethyl 4-(3-(3-carbamoylbenzyl)guanidino)piperidine-1-carboxylate
-
1 mM, 37°C, pH 7, 34% inhibition
histamine
-
250 mM, almost complete inhibition
additional information
-