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2.4.2.31: NAD+-protein-arginine ADP-ribosyltransferase

This is an abbreviated version!
For detailed information about NAD+-protein-arginine ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.31

Reaction

NAD+
+
L-arginine
=
nicotinamide
 +
Nomega-(ADP-D-ribosyl)-L-arginine
 +
H+

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-arginine, actin-specific ADP-ribosyltransferase, ADP-ribosyl-acceptor hydrolase 1, ADP-ribosyltransferase, ADP-ribosyltransferase enzymatic component, ADP-ribosyltransferase-2, ADPRT, alloantigen Rt6.1 , alloantigen Rt6.2 , ALT, arginine ADP-ribosyltransferase 1, arginine specific ADP-ribosyltransferase, arginine specific mono-ADP-ribosyltransferase, arginine-specific adenosine diphosphate ribosyltransferase 1, arginine-specific ADP-ribosyltransferase, arginine-specific ADP-ribosyltransferase 1, arginine-specific ADP-ribosytransferases 1, arginine-specific mono-ADP-ribosyltransferase, arginine-specific mono-ADP-ribosyltransferase 1, arginine-specific mono-ADP-ribosyltransferase A, ARH1, ART, ART1, ART2, ART3, ART4, ART5, Art7.1, Art7.2, ARTase, ARTC1, ARTD15, ARTD15/PARP16, asparagine-specific ADP-ribosyltransferase, AT1 , AT2 , binary toxin, binary toxin A, binary toxin component Ia, C2 toxin, C2I, cARTC2.1, CD196 ADP-ribosyltransferase, CDT, CdtA, cholera toxin, cholix toxin, CTA, Dombrock blood group carrier molecule , exoenzyme C3, glycosylphosphatidylinositol-anchored arginine-specific ADP-ribosyltransferase7.1, i-toxin, iota toxin, MART-A, mono(ADP-ribosyl)transferase , mono-ADP-ribosyl-arginine hydrolase, mono-ADP-ribosyltransferase, mono-ADP-ribosyltransferase A, NAD(P)+-arginine ADP-ribosyltransferase, NAD+:arginine ADP-ribosyltransferase, NAD+:arginine ecto-mono(ADP-ribosyl)transferase, NAD+:L-arginine ADP-D-ribosyltransferase, NAD-arginine ADP-ribosyltransferase, NAD-arginine mono-ADP-ribosyltransferase B, NAD-dependent ADPribosyltransferase, NAD:arginine ADP-ribosyltransferase, NAD:arginine ADP-ribosyltransferase B, NarE, PARP16/ARTD15, RT6, RT6.1, RT6.2, T-cell surface protein Rt6.1 , T-cell surface protein Rt6.2 , TcdB2-TccC3, VIP2, Vis toxin, XAC3230, XopAI

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.31 NAD+-protein-arginine ADP-ribosyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.4.2.31 - NAD+-protein-arginine ADP-ribosyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
actin + NAD+
nicotinamide + ?
show the reaction diagram
-
the ADP ribosylation of actin in the heterophils may be involved in the cellular processes such as phagocytosis, secretion and migration
-
-
?
FGF-2 + NAD+
?
show the reaction diagram
histone + NAD+
Nomega-[(2'-phospho-ADP)-D-ribosyl]-histone-L-arginine + nicotinamide + H+
show the reaction diagram
-
isozyme ART2 is active with high and low molecular weight histones, membrane-bound and PI-PLC released ART2 preferentially ADP-ribosylate high or low MW histones, respectively
-
-
?
human neutrophil peptide-1 + NAD+
Nomega-(ADP-D-ribosyl)-L-arginine-human neutrophil peptide-1 + nicotinamide
show the reaction diagram
-
human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis
-
-
?
NAD+ + agmatine
nicotinamide + Nomega-(ADP-D-ribosyl)-agmatine
show the reaction diagram
-
the enzyme labels L-arginine with ADP-ribose from the NAD(+) substrate at the amino nitrogen of the guanidinium side chain
-
-
r
NAD+ + glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-glucose-regulated protein of 78 kDa/immunoglobulin heavy-chainbinding protein-L-arginine
show the reaction diagram
-
-
-
?
NAD+ + MazF L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-MazF-L-arginine
show the reaction diagram
Tequatrovirus T4
-
the enzyme ADP-ribosylates MazF at an arginine residue at position 4
-
-
?
NAD+ + polyarginine
nicotinamide + Nomega-(ADP-D-ribosyl)-polyarginine
show the reaction diagram
-
-
-
?
NAD+ + protein L-arginine
nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine
show the reaction diagram
NAD+ + [actin]-L-arginine177
nicotinamide + [actin]-N-(ADP-D-ribosyl)-L-arginine177 + H+
show the reaction diagram
nicotinamide + Nomega-(ADP-D-ribosyl)-agmatine-L-arginine
NAD+ + agmatine L-arginine
show the reaction diagram
-
-
-
-
r
additional information
?
-