2.4.1.85: cyanohydrin beta-glucosyltransferase
This is an abbreviated version!
For detailed information about cyanohydrin beta-glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.85
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2.4.1.85
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sorghum
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cyanogenic
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dhurrin
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bicolor
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glucosylates
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cyp71e1
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three-fold
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bitterness
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stereo-selectively
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r-mandelonitrile
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quantitative-pcr
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diglucoside
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testa
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mill
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amygdalus
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kernels
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batsch
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prunus
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prunasin
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metabolons
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compartmentalised
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non-bitter
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dulcis
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rosaceae
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almond
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erratum
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hypervariable
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regiospecificity
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geraniol
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udp-glucosyltransferase
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agriculture
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biotechnology
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synthesis
- 2.4.1.85
- sorghum
-
cyanogenic
- dhurrin
- bicolor
-
glucosylates
- cyp71e1
-
three-fold
-
bitterness
-
stereo-selectively
-
r-mandelonitrile
-
quantitative-pcr
- diglucoside
- testa
-
mill
- amygdalus
- kernels
- batsch
-
prunus
- prunasin
-
metabolons
-
compartmentalised
-
non-bitter
- dulcis
- rosaceae
- almond
-
erratum
-
hypervariable
-
regiospecificity
- geraniol
- udp-glucosyltransferase
- agriculture
- biotechnology
- synthesis
Reaction
Synonyms
cyanohydrin glucosyltransferase, cyanohydrin glycosyltransferase, glucosyltransferase, uridine diphosphoglucose-p-hydroxymandelonitrile, mandelonitrile glucosyltransferase, sbHMNGT, UDP-glucose-p-hydroxymandelonitrile glucosyltransferase, UDP-glucose:p-hydroxymandelonitrile-O-glucosyltransferase, UDP-glucosyltransferase, UGT85B1, uridine diphosphoglucose-cyanohydrin glucosyltransferase, uridine diphosphoglucose-p-hydroxymandelonitrile glucosyltransferase, uridine diphosphoglucose:aldehyde cyanohydrin beta-glucosyltransferase
ECTree
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General Information
General Information on EC 2.4.1.85 - cyanohydrin beta-glucosyltransferase
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malfunction
plant tcd2 mutants deficient in the enzyme have reduced vigor, being dwarfed, with poor root development and low fertility. The mutant plants accumulate numerous dhurrin pathway-derived metabolites, some of which are similar to those observed in transgenic Arabidopsis thaliana expressing the CYP79A1 and CYP71E1 genes. The tcd2 mutant suffers from self-intoxication because Sorghum does not have a feedback mechanism to inhibit the initial steps of dhurrin biosynthesis when the glucosyltransferase activity required to complete the synthesis of dhurrin is lacking. Phenotype, detailed overview
metabolism
physiological function
enzyme UGT85B1 is essential for formation of dhurrin in sorghum with no co-expressed endogenous UDP-glucosyltransferases able to replace it. Presence of metabolites in the tcd2 mutant which are suggested to be derived from dhurrin via endogenous pathways for nitrogen recovery, indicating which enzymes may be involved in such pathways, metabolites identification by LC-MS
glucosylation of R-mandelonitrile to prunasin which is a precursor of amygdalin
metabolism
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UGT85B1 is an important step in product channelling because a rapid glucosylation of the labile p-hydroxymandelonitrile product of CYP71E1 is necessary to avoid its dissociation into p-hydroxybenzaldehyde and hydrogen cyanide
metabolism
dhurrin is a cyanogenic glucoside and its synthesis from the amino acid tyrosine is catalysed by two membrane-bound cytochrome P450 enzymes (CYP79A1 and CYP71E1) and a soluble glucosyltransferase (UGT85B1), and is dependent on electron transfer from a P450 oxidoreductase
metabolism
dhurrin is a cyanogenic glucoside and its synthesis from the amino acid tyrosine is catalysed by two membrane-bound cytochrome P450 enzymes (CYP79A1 and CYP71E1) and a soluble glucosyltransferase (UGT85B1), and is dependent on electron transfer from a P450 oxidoreductase. Dhurrin biosynthesis in Sorghum and the formation of products derived from the different intermediates as part of the detoxification processes or as putative turnover products identified in the tcd2 mutant, overview