2.4.1.267: dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase
This is an abbreviated version!
For detailed information about dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.267
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2.4.1.267
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cdg-ic
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oligosaccharide
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lipid-linked
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n-glycosylation
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croatian
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n-linked
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synthesis
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medicine
- 2.4.1.267
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cdg-ic
- oligosaccharide
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lipid-linked
-
n-glycosylation
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croatian
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n-linked
- synthesis
- medicine
Reaction
Synonyms
ALG6, hALG6
ECTree
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Application
Application on EC 2.4.1.267 - dolichyl-P-Glc:Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase
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medicine
single nucleotide polymorphisms ALG6 rs10889417 G>A and GALNTL4 rs12270446 G>C independently predict cutaneous melanoma disease-specific survival. The low death-risk-associated rs10889417 A allele is associated with increase in ALG6 mRNA expression levels in cultured skin fibroblasts and whole blood cells and the rs12270446 G allele is associated with decrease in GALNTL4 mRNA expression levels in skin tissues
synthesis
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genetic engineering of N-glycan biosynthesis in Yarrowia lipolytica so that it produces Man(3)GlcNAc(2) structures on its glycoproteins. Disruption of the ALG3 gene, EC 2.4.1.258, results in modification of proteins mainly with Man(5)GlcNAc(2) and GlcMan(5)GlcNAc(2) glycans, and to a lesser extent with Glc(2)Man(5)GlcNAc(2) glycans. To avoid underoccupancy of glycosylation sites, Alg6, EC 2.4.1.267, is concomitantly overexpressed. Overexpression of the heterodimeric Aspergillus niger glucosidase II results in removal the terminal glucose residues. Overexpression of an alpha-1,2-mannosidase leads to Man(3)GlcNAc(2) structures, which are substrates for the synthesis of complex-type glycans. The final Yarrowia lipolytica strain produces proteins glycosylated with the trimannosyl core N-glycan (Man(3)GlcNAc(2)), which is the common core of all complex-type N-glycans