2.4.1.257: GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

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For detailed information about GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase, go to the full flat file.

Reaction

Synonyms

Alg2, Alg2 mannosyltransferase, Alg2 MTase, More, MTase, scAlg2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.257 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

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Results	in table
3485	AA Sequence
1	Application
3	Cloned(Commentary)
5	General Information
9	Localization
1	Metals/Ions
5	Natural Substrates/ Products (Substrates)
7	Organism
6	Pathway
4	pH Optimum
1	Posttranslational Modification
31	Protein Variants
3	Purification (Commentary)
1	Reaction
7	Reference
12	Substrates and Products (Substrate)
12	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.1.257 - GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

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SYSTEMATIC NAME

IUBMB Comments

GDP-D-mannose:D-Man-alpha-(1->3)-D-Man-beta-(1-4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-6-mannosyltransferase

The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation (cf. EC 2.4.1.132) of beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation, to form the first branched pentasaccharide intermediate of the dolichol pathway [1,2].