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Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP
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-
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?
Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xylbeta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Gal(6-O-sulfate)beta(1-4)Xylbeta1-O-Ser + UDP
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-
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?
Galbeta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser + UDP
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-
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?
Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser + UDP-GlcUA
GlcUAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser + UDP
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?
UDP-alpha-D-glucuronate + Galbeta1,3Galbeta-O-naphthalenemethanol
?
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?
UDP-alpha-D-glucuronate + Galbeta1,3GalNAcbeta-O-naphthalenemethanol
?
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?
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
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?
UDP-Gal + Galbeta(1-3)Gal
Galbeta(1-3)Galbeta(1-3)Gal + UDP
no activity with wild-type enzyme, weak activity with mutant enzyme H308R
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?
UDP-galacturonic acid + Galbeta(1-3)Gal
Galbeta(1-3)Galbeta(1-3)Gal + UDP
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?
UDP-GlcNAc + Galbeta(1-3)Gal
GlcNAcbeta(1-3)Galbeta(1-3)Gal + UDP
no activity with wild-type enzyme, activity with mutant enzyme H308R is nearly equal to activity with UDP-Glc
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?
UDP-glucose + galactosyl-1,3-thiogalactose
?
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?
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP-glucuronate + Galbeta(1-3)Gal
GlcAbeta(1-3)Galbeta(1-3)Gal + UDP
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?
UDP-glucuronate + Galbeta(1-3)Gal(6-sulfate)beta1-O-methoxyphenyl
UDP + ?
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?
UDP-glucuronate + Galbeta(1-3)Gal-O-benzyl
UDP + ?
best substrate
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?
UDP-glucuronate + Galbeta(1-3)Gal-O-naphthalenemethanol
UDP + ?
best substrate
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?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
UDP + GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xyl-1-O-Ser
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?
UDP-glucuronate + Galbeta(1-3)Galbeta1-O-methoxyphenyl
UDP + ?
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?
UDP-glucuronate + Galbeta(1-3)GlcNAcalpha-O-benzyl
UDP + ?
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?
UDP-glucuronate + Galbeta(1-3)GlcNAcalpha-O-naphthalenemethanol
UDP + ?
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?
UDP-glucuronate + Galbeta(1-3)GlcNAcbeta-O-naphthalenemethanol
UDP + ?
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?
UDP-glucuronate + Galbeta(1-4)Glcbeta-O-naphthalenemethanol
UDP + ?
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?
UDP-glucuronate + Galbeta(1-4)GlcNAcbeta-O-naphthalenemethanol
UDP + ?
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?
UDP-glucuronate + Galbeta-O-1-naphthol
UDP + GlcAbeta(1-3)Galbeta-O-1-naphthol
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?
UDP-glucuronate + Galbeta-O-2-naphthol
UDP + GlcAbeta(1-3)Galbeta-O-2-naphthol
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?
UDP-glucuronate + Galbeta1-3Gal
UDP + Galbeta1-3Galbeta1-3Gal
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the enzyme exhibits a strict selectivity towards Galbeta1-3Gal structures
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?
UDP-Man + Galbeta(1-3)Gal
Manbeta(1-3)Galbeta(1-3)Gal + UDP
no activity with wild-type enzyme, efficient reaction with mutant enzyme H308R
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?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
?
UDPglucuronate + 3-beta-D-galactosyl-D-galactose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactose
UDPglucuronate + 3-beta-D-galactosyl-D-galactosyl-4-xylose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactosyl-4-xylose
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?
UDPglucuronate + 3-beta-D-galactosyl-D-galactosyl-4-xylosylserine
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactosyl-4-xylosylserine
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?
additional information
?
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UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
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?
UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
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plays a key role in glycosaminoglycan biosynthesis
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?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
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?
UDP-glucuronate + Galbeta(1-3)Galbeta(1-4)Xyl
UDP + GlcAbeta(1-3)-Galbeta(1-3)Galbeta(1-4)Xyl
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high expression of the GlcAT-I gene renders the cells capable of synthesizing the HNK-1 epitope
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?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
?
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involved in the biosynthesis of the polysaccharide-protein-linkage region of proteochondroitin sulfate
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?
UDPglucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein
?
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involved in the biosynthesis of the heparin-polypeptide linkage region
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?
UDPglucuronate + 3-beta-D-galactosyl-D-galactose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactose
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transfer to non-reducing terminal
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?
UDPglucuronate + 3-beta-D-galactosyl-D-galactose
UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-D-galactose
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?
additional information
?
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mutant lacking glucuronosyltransferase I fails to make both heparan sulfate and chondroitin sulfate
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?
additional information
?
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no activity with Galalpha-O-p-nitrophenol, Galbeta-O-p-nitrophenol, Galalpha-O-a-naphthol, GalNAcalpha-O-p-nitrophenol, GalNAcbeta-O-p-nitrophenol
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?
additional information
?
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no activity with Galalpha-O-p-nitrophenol, Galbeta-O-p-nitrophenol, Galalpha-O-a-naphthol, GalNAcalpha-O-p-nitrophenol, GalNAcbeta-O-p-nitrophenol
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?
additional information
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analysis of glycan structure by mass spectrometry. Activity analysis of enzyme splicing variants, overview
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additional information
?
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the uridine diphosphate binding region plays an important role in enzyme activity of the enzyme
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?
additional information
?
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galactosyl-beta-1,6-galactose is a less effective acceptor substrate
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?
additional information
?
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galactosyl-beta-1,4-galactose is a less effective acceptor substrate
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?
additional information
?
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negligible activity with Galbeta(1-3)galbeta1-O-benzyl, galbeta(1-4)GlcNAc and galbeta(1-4)Glc
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?
additional information
?
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the enzyme is involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans
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?
additional information
?
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the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans
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?
additional information
?
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the enzyme forms the glycosaminoglycan-protein linkage region, GlcAbeta(1-3)Galbeta(1-3)Galbeta(1-4)Xylbeta1-O-Ser, of the proteoglycans
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?
additional information
?
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enzyme is involved in heparan sulfate and chondroitin sulfate biosynthesis
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?
additional information
?
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central enzyme in the initial steps of proteoglycan synthesis
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?
additional information
?
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expressed in Pichia pastoris
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?
additional information
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enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains
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?
additional information
?
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enzyme plays a key role in proteoglycan biosynthesis by catalyzing the transfer of glucuronic acid onto the trisaccharide-protein linkage structure Galbeta(1-3)Galbeta(1-4)Xyl-O-Ser, a prerequisite step for polymerization of glycosaminoglycan chains
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?
additional information
?
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the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence
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?
additional information
?
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the enzyme is responsible for the complementation of the glycosaminoglycan primer sequence
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?
additional information
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no activity with wild-type enzyme: UDP-Glc, IDP-Gal, UDP-Man and UDP-GlcNAc
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?
additional information
?
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no activity with wild-type enzyme: UDP-Glc, IDP-Gal, UDP-Man and UDP-GlcNAc
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?
additional information
?
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no substrate Gal(6-O-sufate)beta(1-3)Galbeta(1-4)Xyl(2-O-phosphate)beta1-O-Ser
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?
additional information
?
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no substrate Gal(6-O-sufate)beta(1-3)Galbeta(1-4)Xylbeta1-O-Ser
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?
additional information
?
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galactosyl-beta-1,4-xylose, galactosyl-beta-1,4-glucose is a less effective acceptor substrate
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?
additional information
?
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galactosyl-beta-1,6-galactose is a less effective acceptor substrate
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?