2.4.1.133: xylosylprotein 4-beta-galactosyltransferase This is an abbreviated version! For detailed information about xylosylprotein 4-beta-galactosyltransferase, go to the full flat file .
Reaction
UDP-alpha-D-galactose +
[protein]-3-O-(beta-D-xylosyl)-L-serine =
UDP +
[protein]-3-O-(beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-serine
Synonyms B4GALT7, beta-1,4 galactosyltransferase I, beta-1,4 galactosyltransferase V, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 7, beta-1,4-galactosyltransferase I, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-T7, beta-1,4-GalT, beta-1,4-GalT 7, beta-1,4-GalT I, beta-1,4-GalT V, beta-1,4-GalT-I, beta1,4-galactosyltransferase 7, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase VII, beta1,4-galactosyltransferase-7, beta1,4-GalT, beta1,4-GalT-I, beta1,4-GalT7, beta4-galactosyltransferase 7, beta4Gal-T7, beta4galactosyltransferase I, beta4GalT-7, beta4GalT7, dbeta4GalTI, galactosyltransferase I, galactosyltransferase, uridine diphosphogalactose-xylose, GalT I, GalT-I, hbeta4GalT7, MgGalT7, pNP-xylose-beta-1,4-galactosyltransferase, proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I, SQV-3, UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, UDPgalactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase, xylosylprotein 4-beta-galactosyltransferase, xylosylprotein beta1,4-galactosyltransferase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 2.4.1.133 - xylosylprotein 4-beta-galactosyltransferase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UDP-alpha-D-galactose + 2-naphthyl beta-D-xylopyranoside
UDP + 4-beta-D-galactosyl-2-naphthyl-beta-D-xylopyranoside
-
-
-
?
UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein]
UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
UDP-galactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
UDPgalactose + N-acetyl-beta-D-glucosamine
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
-
-
-
-
?
UDPgalactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
additional information
?
-
UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein]
UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
-
-
-
?
UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein]
UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
-
-
-
?
UDP-alpha-D-galactose + O-beta-D-xylosyl-[protein]
UDP + 4-beta-D-galactosyl-O-beta-D-xylosyl-[protein]
-
-
-
?
UDP-galactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
-
-
?
UDP-galactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
in a progeroid patient carrying two point mutations in beta4galactosyltransferase I (ß4GalT-7) only 50% of the decorin core protein molecules are substituted with glycosaminoglycan chains. Tthe ß4GalT-7 mutations directly affect the molecular phenotype of decorin observed in a patient with the progeroid form of Ehlers-Danlos syndrome, which may be a major mechanistic cause for the skin and wound healing defects observed in this patient
-
-
?
UDP-galactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
-
-
-
?
UDPgalactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
the enzyme transfers a galactose to the beta-xylose residue in proteolycan. The enzyme is essential for viability
-
-
?
UDPgalactose + O-beta-D-xylosylprotein
UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
-
involved in chondroitin sulfate biosynthesis
-
-
?
additional information
?
-
beta-1,4-galactosyltransferase is responsible for the biosynthesis of Gal-beta - 4GlcNAc units in N-glycans and core 2 O-glycans of glycoproteins, including IgG, gp120 and serum alpha-fetoprotein
-
-
?
additional information
?
-
some beta-D-xylosides, such as 2-naphthyl beta-D-xylopyranoside, can induce glycosaminoglycan synthesis by serving as acceptor substrates for beta4GalT7 and by that also compete with the glycosaminoglycan synthesis on core proteins
-
-
?
additional information
?
-
-
enzyme catalyzes the transfer of galactose from the sugar nucleotide donor uridine diphosphate galactose to glycoside residues with a terminal N-acetylglucosamine moiety
-
-
?
additional information
?
-
-
enzyme transfers galactose to the terminal N-acetylglucosamine of N- and O-linked glycans in a beta-1,4-linkage
-
-
?