2.3.1.67: 1-alkylglycerophosphocholine O-acetyltransferase

This is an abbreviated version!
For detailed information about 1-alkylglycerophosphocholine O-acetyltransferase, go to the full flat file.

Reaction

Synonyms

1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA: lyso-PAF acetyltransferase, acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine 2-O-acetyltransferase, acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acetyl-CoA:lyso-PAF acetyltransferase, acetyl-CoA:lysoPAF acetyltransferase, acetyl-coenzyme A:1-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase, acetyl-coenzymeA:lysoPAF acetyltransferase, acetyltransferase, 1-alkyl-2-lysolecithin, acetyltransferase, 1-alkylglycerophosphocholine, acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acyltransferase, blood platelet-activating factor acetyltransferase, lpafat1, LPCAT1, LPCAT2, lyso-GPC:acetyl CoA acetyltransferase, lyso-PAF acetyltransferase, lyso-PAF acetyltransferase:LPC acyltransferase 1, lyso-PAF AT, Lyso-PAF ATC, Lyso-PAF ATE, lyso-PAF-acetyltransferase, lyso-PAF-AcT, Lyso-PAF-AT, lyso-PAF:acetyl-CoA acetyltransferase, lyso-PAFAT, lyso-platelet activating factor:acetyl-CoA acetyltransferase, lyso-platelet-activating factor acetyltransferase, lyso-platelet-activating factor:acetyl-CoA acetyltransferase, lysoPAF-AT, lysoPAF:acetyl CoA acetyltransferase, lysoPAFAT, lysophosphatidylcholine acyltransferase (LPCAT2)/lyso-PAF acetyltransferase, lysophosphatidylcholine acyltransferase 1, mLysoPAFAT/LPCAT2, PAF acetyltransferase, platelet-activating factor acylhydrolase, platelet-activating factor-synthesizing enzyme

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.67 1-alkylglycerophosphocholine O-acetyltransferase

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Results	in table
18	Activating Compound
37	AA Sequence
8	Application
1	CAS Registry Number
8	Cloned(Commentary)
7	Cofactor
3	Disease/ Diagnostics
8	Expression
13	General Information
4	General Stability
63	IC50 Value
141	Inhibitors
17	KM Value [mM]
21	Localization
6	Metals/Ions
3	Molecular Weight [Da]
19	Natural Substrates/ Products (Substrates)
51	Organism
2	Pathway
29	pH Optimum
2	pH Range
2	Posttranslational Modification
10	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reaction Type
48	Reference
63	Source Tissue
24	Specific Activity [micromol/min/mg]
80	Substrates and Products (Substrate)
1	Subunits
76	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.3.1.67 - 1-alkylglycerophosphocholine O-acetyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

2 entries

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

5 entries

acetyl-CoA + 1-O-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-6-phosphocholine

Homo sapiens

-

final step in remodelling pathway of PAF biosynthesis

487375

-

487375

?

acetyl-CoA + lyso-platelet activating factor

CoA + platelet activating factor

Homo sapiens

-

-

758268

-

-

?

acetyl-CoA + lyso-platelet-activating factor

?

Homo sapiens

-

-

756321

-

-

?

acetyl-CoA + lyso-platelet-activating factor

platelet-activating factor + CoA

2 entries

additional information

?

-

6 entries

1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

Homo sapiens

-

lyso-PAF, lyso-platelet-activating factor

701601, 702406, 703250

PAF, platelet-activating factor

-

?

1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA

1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

Mus musculus

Q3TFD2

lyso-PAF, lyso-platelet-activating factor

704418

PAF, platelet-activating factor

-

?

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Homo sapiens

-

-

672336

-

-

?

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Homo sapiens

Q7L5N7

-

736604

-

-

?

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Mus musculus

Q8BYI6

-

736450, 736604

-

-

?

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Mus musculus

-

-

736604

-

-

?

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphocholine

CoA + 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine

Mus musculus C57/BL6J

Q8BYI6

-

736450

-

-

?

acetyl-CoA + lyso-platelet-activating factor

platelet-activating factor + CoA

Homo sapiens

Q7L5N7

-

672495

-

-

?

acetyl-CoA + lyso-platelet-activating factor

platelet-activating factor + CoA

Mus musculus

Q8BYI6

-

688161

-

-

?

additional information

?

-

Homo sapiens

Q7L5N7

enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF

674893

-

-

?

additional information

?

-

Mus musculus

-

the enzyme is activated 1. by a second-order time course after stimulation with platelet-activating factor receptor, 2. by a minute-order time course after LPS stimulation in the MyD88-dependent and p38 MAPK-dependent pathway, and 3. by an hour-order time course after LPS-stimulation in the MyD88-independent and TRIF-independent pathway

659628

-

-

?

additional information

?

-

Mus musculus

Q8BYI6

enzyme is induced by bacterial endotoxin. The enzyme catalyzes not only biosynthesis of PAF from lyso-PAF but also incorporation of arachidonoyl-CoA to produce PAF precursor membrane glycerophospholipids (lysophosphatidylcholine acyltransferase activity). Under resting conditions, the enzyme prefers arachidonoyl-CoA and contributes to membrane biogenesis. Upon acute inflammatory stimulation with lipopolysaccharide, the activated enzyme utilizes acetyl-CoA more efficiently and produces PAF

674893

-

-

?

additional information

?

-

Mus musculus

Q8BYI6

LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine

736450

-

-

?

additional information

?

-

Mus musculus

-

LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine

736450

-

-

?

additional information

?

-

Mus musculus C57/BL6J

Q8BYI6

LPCAT2 also possesses lysophosphatidylcholine acyltransferase, EC: 2.3.1.23, activity that catalyzes the incorporation of arachidonoyl-CoA into membrane phosphatidylcholine

736450

-

-

?