2.1.1.98: diphthine synthase
This is an abbreviated version!
For detailed information about diphthine synthase, go to the full flat file.
Word Map on EC 2.1.1.98
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2.1.1.98
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diphthamide
-
toxin
-
pyrococcus
-
horikoshii
-
trimethylation
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diphtheria
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eef2
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ill-defined
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eukaryal
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amidase
- 2.1.1.98
- diphthamide
- toxin
-
pyrococcus
- horikoshii
-
trimethylation
-
diphtheria
- eef2
-
ill-defined
-
eukaryal
- amidase
Reaction
3 S-adenosyl-L-methionine + = 3 S-adenosyl-L-homocysteine +
Synonyms
diphthine methyltransferase, diphthine synthase, Dph5, methyltransferase, diphthine, S-adenosyl-L-methionine:elongation factor 2 methyltransferase
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.98 - diphthine synthase
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S-adenosyl-L-methionine:2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] methyltransferase (diphthine-[translation elongation factor 2]-forming)
This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14, diphthine---ammonia ligase. Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314). In the archaeon Pyrococcus horikoshii the enzyme acts on His600 of elongation factor 2.