2.1.1.62: mRNA (2'-O-methyladenosine-N6-)-methyltransferase
This is an abbreviated version!
For detailed information about mRNA (2'-O-methyladenosine-N6-)-methyltransferase, go to the full flat file.
Reaction
Synonyms
cap-dependent 2'-O-methyltransferase, messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, mRNA cap (nucleoside-2'O)-methyltransferase, NS5MTaseDV, VP39
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.62 - mRNA (2'-O-methyladenosine-N6-)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + 7MeGpppAC5
S-adenosyl-L-homocysteine + 7MeGpppA2'OMeC5
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RNA substrate is used
-
-
?
S-adenosyl-L-methionine + G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + G(5')pppm6Am-mRNA
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poor substrate
-
-
?
S-adenosyl-L-methionine + m7G(5')pppA-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6A-mRNA
-
-
-
-
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
S-adenosyl-L-methionine + pppA-mRNA
S-adenosyl-L-homocysteine + pppm6A-mRNA
-
-
-
-
?
additional information
?
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no substrates are the oligonucleotides m7G(5')pppAm, m7G(5')pppA, m7G(5')pppAmpN, no methyl group acceptors are brome mosaic virus RNA, E. coli tRNA and rRNA and yeast tRNA
-
-
?
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
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methyl group acceptor is methylated or unmethylated vaccinia virus RNA
mRNA containing an N6,2'-O-dimethyladenosine cap
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
-
involved in post-transcriptional modification of 5'-end of messenger-RNA
mRNA containing an N6,2'-O-dimethyladenosine cap
?
S-adenosyl-L-methionine + m7G(5')pppAm-mRNA
S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA
Variola sp.
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also acts as poly(A) polymerase progressivity factor
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-
?