2.1.1.256: tRNA (guanine6-N2)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanine6-N2)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.256
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2.1.1.256
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nucleosides
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n2-methylguanosine
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pyrococcus
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thermophilus
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thermus
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methyltransferases
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thump
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furiosus
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rossmann-fold
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guanosine
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trnaphe
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trna-modifying
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mtases
- 2.1.1.256
- nucleosides
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n2-methylguanosine
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pyrococcus
- thermophilus
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thermus
- methyltransferases
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thump
- furiosus
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rossmann-fold
- guanosine
- trnaphe
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trna-modifying
- mtases
Reaction
Synonyms
G6 MTase, m2G6 methyltransferase, m2G6 tRNA methylase, methyltransferase Trm14, PF1002, PfTrm14, Trm14, TrmN, tRNA (m2G6) methyltransferase, tRNA m2G6 methyltransferase, tRNA m2G6 MTase, tRNA:m2G6 methyltransferase, TTC1157, TTCTrmN
ECTree
2.1.1.256 tRNA (guanine6-N2)-methyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.1.1.256 - tRNA (guanine6-N2)-methyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + guanine37 in tRNATrp
S-adenosyl-L-homocysteine + N2-methylguanine37 in tRNATrp
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-
-
-
?
S-adenosyl-L-methionine + guanine54 in tRNATrp
S-adenosyl-L-homocysteine + N2-methylguanine54 in tRNATrp
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-
-
-
?
S-adenosyl-L-methionine + guanine6 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
S-adenosyl-L-methionine + guanine6 in tRNA(Phe)
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA(Phe)
S-adenosyl-L-methionine + guanine6 in tRNACys
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys
S-adenosyl-L-methionine + guanine67 in tRNATrp
S-adenosyl-L-homocysteine + N2-methylguanine67 in tRNATrp
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-
-
-
?
S-adenosyl-L-methionine + guanine8 in tRNATrp
S-adenosyl-L-homocysteine + N2-methylguanine8 in tRNATrp
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-
-
-
?
S-adenosyl-L-methionine + guanine6 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
the enzyme specifically modifies tRNAPhe at guanosine 6 in the tRNA acceptor stem
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-
?
S-adenosyl-L-methionine + guanine6 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
the enzyme specifically modifies tRNAPhe at guanosine 6 in the tRNA acceptor stem. Contribution of the THUMP domain in tRNA recognition and catalysis, substrate binding and ligand-induced conformational changes in the RFM domain
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-
?
S-adenosyl-L-methionine + guanine6 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
the enzyme specifically modifies tRNAPhe at guanosine 6 in the tRNA acceptor stem
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-
?
S-adenosyl-L-methionine + guanine6 in tRNA
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
the enzyme specifically modifies tRNAPhe at guanosine 6 in the tRNA acceptor stem. Contribution of the THUMP domain in tRNA recognition and catalysis, substrate binding and ligand-induced conformational changes in the RFM domain, overview
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-
?
S-adenosyl-L-methionine + guanine6 in tRNA(Phe)
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA(Phe)
production of a small amount of N2-dimethylguanine6 in tRNA(Phe)
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-
?
S-adenosyl-L-methionine + guanine6 in tRNA(Phe)
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA(Phe)
production of a small amount of N2-dimethylguanine6 in tRNA(Phe)
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-
?
S-adenosyl-L-methionine + guanine6 in tRNA(Phe)
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA(Phe)
production of a small amount of N2-dimethylguanine6 in tRNA(Phe)
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-
?
S-adenosyl-L-methionine + guanine6 in tRNACys
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys
Trm14 generates m2G at position 6 in tRNACys
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-
?
S-adenosyl-L-methionine + guanine6 in tRNACys
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys
wild-type or G6A/C67U tRNACys transcripts as substrates, Trm14 generates m2G at position 6 in tRNACys, i.e. tRNACys m2G6-forming activity
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-
?
S-adenosyl-L-methionine + guanine6 in tRNACys
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys
Trm14 generates m2G at position 6 in tRNACys
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-
?
S-adenosyl-L-methionine + guanine6 in tRNACys
S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNACys
wild-type or G6A/C67U tRNACys transcripts as substrates, Trm14 generates m2G at position 6 in tRNACys, i.e. tRNACys m2G6-forming activity
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-
?
additional information
?
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active site structure with bound ligands, S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, and sinefungin, overview
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?
additional information
?
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active site structure with bound ligands, S-adenosyl-L-methionine, S-adenosyl-L-homocysteine, and sinefungin, overview
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?
additional information
?
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docking model of TrmN in complex with tRNAPhe of Thermus thermophilus
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?
additional information
?
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docking model of TrmN in complex with tRNAPhe of Thermus thermophilus
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?
