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2.1.1.177: 23S rRNA (pseudouridine1915-N3)-methyltransferase

This is an abbreviated version!
For detailed information about 23S rRNA (pseudouridine1915-N3)-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
pseudouridine1915 in 23S rRNA
=
S-adenosyl-L-homocysteine
 +
N3-methylpseudouridine1915 in 23S rRNA

Synonyms

m3Psi methyltransferase, pseudouridine methyltransferase, Psi1915-specific methyltransferase, RlmH, rRNA large subunit methyltransferase H, YbeA

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.177 23S rRNA (pseudouridine1915-N3)-methyltransferase

Engineering

Engineering on EC 2.1.1.177 - 23S rRNA (pseudouridine1915-N3)-methyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E138A
loss of activity, equilibrium dissociation constants for the first SAM binding site in the RlmH dimer is similar to wild-type
E138Q
loss of activity, equilibrium dissociation constants for the first SAM binding site in the RlmH dimer is similar to wild-type
H129A
about 17% of wild-type activity
H153F
loss of activity, equilibrium dissociation constants for the first SAM binding site in the RlmH dimer is similar to wild-type
R142A
about 3% of wild-type activity
R154A
loss of activity, equilibrium dissociation constants for the first SAM binding site in the RlmH dimer is similar to wild-type
Y152F
loss of activity, equilibrium dissociation constants for the first SAM binding site in the RlmH dimer is similar to wild-type