2.1.1.17: phosphatidylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.17
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2.1.1.17
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phosphatidylcholine
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choline
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homocysteine
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cytidylyltransferase
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cdp-choline
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betaine
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s-adenosylhomocysteine
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ctp:phosphocholine
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cdp-diacylglycerol
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phosphatidyl-n,n-dimethylethanolamine
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phosphatidyl-n-monomethylethanolamine
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choline-deficient
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transmethylation
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n-methyltransferases
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kennedy
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adomet
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vance
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phosphatidylmonomethylethanolamine
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medicine
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ptdcho
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analysis
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phosphatidyldimethylethanolamine
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mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
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ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
-
choline-deficient
-
transmethylation
- n-methyltransferases
-
kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
-
remethylation
-
cholinephosphotransferase
-
adohcy
-
choline-supplemented
Reaction
Synonyms
lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3
ECTree
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Activating Compound
Activating Compound on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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1-methyl-4-phenylpyridinium
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enhances activity. S-Adenosylmethionine hypermethylation can be involved in the etiology of Parkinsons disease and an increase of phospholipid methylation could be one of the mechanisms by which 1-methyl-4-phenyl-pyridinium causes parkinsonism
betaine
attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway, the effect is enhanced by ethanol, which alone has no effect on expression levels of the enzyme, overview
ethanol
enhances the inducing and protecting effects of betaine on the enzyme, alone has only a slightly activating effect on the enzyme activity, overview
progesterone
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physiological levels of progesterone activate PE-NMT and sphingomyelin synthase
additional information
17-beta-estradiol induces the enzyme in hepatocytes
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additional information
17-beta-estradiol induces the enzyme in hepatocytes
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