1.5.3.14: polyamine oxidase (propane-1,3-diamine-forming)

This is an abbreviated version!
For detailed information about polyamine oxidase (propane-1,3-diamine-forming), go to the full flat file.

Reaction

Synonyms

EC 1.5.3.11, flavin-containing polyamine oxidase, maize PAO, maize polyamine oxidase, MPAO, OsPAO7, PAO, ZmPAO

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.3 With oxygen as acceptor

                1.5.3.14 polyamine oxidase (propane-1,3-diamine-forming)

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
20	AA Sequence
2	Application
8	Cloned(Commentary)
8	Cofactor
2	Crystallization (Commentary)
5	Expression
12	General Information
75	Inhibitors
14	kcat/KM [mM/s]
46	Ki Value [mM]
31	KM Value [mM]
11	Localization
1	Metals/Ions
1	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
25	Organism
4	Pathway
3	PDB ID
9	pH Optimum
1	pH Stability
4	Posttranslational Modification
6	Protein Variants
7	Purification (Commentary)
1	Reaction
23	Reference
15	Source Tissue
1	Specific Activity [micromol/min/mg]
45	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Stability [°C]
28	Turnover Number [1/s]

Application

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Application on EC 1.5.3.14 - polyamine oxidase (propane-1,3-diamine-forming)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Application Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Zea mays

-

under drought stress, expression of polyamine oxidase genes PAO1, PAO2, PAO3, PAO4,PAO5, PAO6 and activity of enzymatic polyamine oxidation is increased in both relatively tolerant (Karoon) and sensitive (260) maize cultivars. The enhancement in PAO gene expression and enzyme activity is more prominent in Karoon cultivar compared to 260

765115

medicine

Zea mays

-

exogenous spermine and PAO treatment decrease cell viability in a spermine dose- and time-dependent manner, particularly, the viability of the multidrug-resistant colon adenocarcinoma cells, LoVo DX, when compared with drug-sensitive ones. H2O2 derived from spermine is mainly responsible for the cytotoxicity. Treatment with PAO and spermine increases the apoptotic population of LoVo wild-type and multidrug-resistant LoVo cells. Treatment with PAO and spermine markedly reduces mitochondrial membrane potential in the multidrug-resistant LoVo cells

764933