1.4.1.24: 3-dehydroquinate synthase II
This is an abbreviated version!
For detailed information about 3-dehydroquinate synthase II, go to the full flat file.
Word Map on EC 1.4.1.24
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1.4.1.24
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1-phosphate
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cyclization
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semialdehyde
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shikimate
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deamination
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l-aspartate
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jannaschii
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methanocaldococcus
- 1.4.1.24
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1-phosphate
-
cyclization
-
semialdehyde
- shikimate
-
deamination
- l-aspartate
- jannaschii
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methanocaldococcus
Reaction
Synonyms
aroB', aroB2, dehydroquinate synthase II, DHQ synthase, DHQ synthase II, DHQS, MJ1249, MJ1249 protein, type II 3-dehydroquinate synthase
ECTree
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Systematic Name
Systematic Name on EC 1.4.1.24 - 3-dehydroquinate synthase II
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2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.