1.3.3.4: protoporphyrinogen oxidase
This is an abbreviated version!
For detailed information about protoporphyrinogen oxidase, go to the full flat file.
Word Map on EC 1.3.3.4
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1.3.3.4
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herbicide
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heme
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porphyria
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variegate
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chlorophyl
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weed
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coproporphyrinogen
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acifluorfen
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ferrochelatase
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diphenyl
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tetrapyrrole
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porphobilinogen
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ppo-inhibiting
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amaranthus
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flumioxazin
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tuberculatus
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glyphosate
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neurovisceral
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5-aminolevulinic
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oxyfluorfen
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acetolactate
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uroporphyrinogen
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fomesafen
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oxadiazon
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broadleaf
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target-site
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agriculture
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postemergence
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glufosinate
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waterhemp
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herbicide-resistant
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porphyrinogenic
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coproporphyria
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diphenylether
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oxidase-inhibiting
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rudis
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glyphosate-resistant
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sauer
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diagnostics
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medicine
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drug development
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mesotrione
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analysis
- 1.3.3.4
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herbicide
- heme
- porphyria
- variegate
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chlorophyl
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weed
- coproporphyrinogen
- acifluorfen
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ferrochelatase
-
diphenyl
- tetrapyrrole
- porphobilinogen
-
ppo-inhibiting
- amaranthus
- flumioxazin
- tuberculatus
- glyphosate
-
neurovisceral
-
5-aminolevulinic
- oxyfluorfen
- acetolactate
- uroporphyrinogen
- fomesafen
- oxadiazon
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broadleaf
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target-site
- agriculture
-
postemergence
- glufosinate
-
waterhemp
-
herbicide-resistant
-
porphyrinogenic
- coproporphyria
- diphenylether
-
oxidase-inhibiting
- rudis
-
glyphosate-resistant
-
sauer
- diagnostics
- medicine
- drug development
- mesotrione
- analysis
Reaction
Synonyms
HemG, HemG-type PPO, HemG-type protoporphyrinogen IX oxidase, hemY, hPPO, H_N10, H_N40, H_N90, LMJF_06_1280, mtPPO, MxPPOX, MxProtox, PPO, PPO1, ppo1-1, PPO2, PPOX, PPOX I, PPX1, PPX2, protein YfeX, protogen oxidase, protoporphyrinogen IX oxidase, protoporphyrinogen IX oxidase 1, protoporphyrinogen oxidase, protoporphyrinogen oxidase IX, protoporphyrinogenase, protox, Protox enzyme, R-PPO, Rs-slr1790 protein, S-PPO, Salk_143057, YfeX
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 1.3.3.4 - protoporphyrinogen oxidase
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REACTION DIAGRAM
protoporphyrinogen IX + 3 O2
protoporphyrin + 3 H2O2
Thermosynechococcus vestitus
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during heme and chlorophyll biosynthesis, the flavin-dependent protoporphyrinogen IX oxidase catalyzes the six-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. In the following step, iron is inserted into protoporphyrin IX by ferrochelatase. The two enzymes are organized in an enzyme complex, overview
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protoporphyrinogen IX + 3 O2
protoporphyrin IX + 3 H2O2
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protoporphyrinogen IX + 3 O2
protoporphyrin IX + 3 H2O2
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protoporphyrinogen IX + 3 O2
protoporphyrin IX + 3 H2O2
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protoporphyrinogen IX + 3 O2
protoporphyrin IX + 3 H2O2
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?
protoporphyrinogen IX + 3 O2
protoporphyrin IX + 3 H2O2
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?
protoporphyrinogen IX + 3 O2
protoporphyrin IX + 3 H2O2
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?
protoporphyrin IX + H2O
20fold lower activity with protoporphyrinogen IX compared to coproporphyrinogen III
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protoporphyrinogen IX + O2
protoporphyrin IX + H2O
20fold lower activity with protoporphyrinogen IX compared to coproporphyrinogen III
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate step before the chlorophyl and heme synthesis diverge in plants
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate enzyme in the heme biosynthesis, several mutations of the enzyme encoding gene are responsible for variegate porphyria
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
the penultimate step in the heme biosynthesis, enzyme deficiency causes variegate porphyria
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
Megalodesulfovibrio gigas
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does not utilize O2 but 2,6-dichlorophenolindophenol as electron acceptor
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
Megalodesulfovibrio gigas
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penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
enzyme deficiency causes variegate porphyria, bringing about e.g. light-sensitivity of human skin
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
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penultimate step of heme and chlorophyll biosynthesis
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?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
-
?
protoporphyrinogen-IX + 3 O2
protoporphyrin-IX + 3 H2O2
-
penultimate step of heme and chlorophyll biosynthesis
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?
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enzyme PPO1 directly interacts with proteins MORF2, MORF9, or MORF8, interaction analysis, overview. The RNA editing function of PPO1 depends on its interaction with MORFs
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additional information
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enzyme PPO1 directly interacts with proteins MORF2, MORF9, or MORF8, interaction analysis, overview. The RNA editing function of PPO1 depends on its interaction with MORFs
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additional information
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mutations of enzyme-encoding gene PPOX are involved in variegate porphyria, an acute hepatic porphyria, which is characterized by skin lesions and acute neuropsychatric/cisceral attacks due to enzyme deficiency
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additional information
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the enzyme from Leishmania major also shows a physiological ferrochelatase activity
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additional information
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the enzyme might be complexed in vivo with the ferrochelatase for substrate channeling
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additional information
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the enzyme might be complexed in vivo with the ferrochelatase for substrate channeling
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?