1.13.11.67: 8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase

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For detailed information about 8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase, go to the full flat file.

Word Map on EC 1.13.11.67

1.13.11.67

cortisone

hydroxysteroid

taqman

polycystic

11-beta

11beta-hydroxysteroid

postmenopausal

hyperandrogenism

myotubes

infusions

population-based

hsd11b2

intrauterine

tacrolimus

corticosterone

conceptus

ovine

femoral

inconclusive

ruminants

Reaction

Synonyms

carotenoid cleavage dioxygenase, CarT, CCD, EC 1.13.12.12, torulene oxygenase

ECTree

1 Oxidoreductases

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.13.11 With incorporation of two atoms of oxygen

1.13.11.67 8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase

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Results	in table
4	Activating Compound
2	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
1	Crystallization (Commentary)
2	Inhibitors
4	KM Value [mM]
1	Metals/Ions
4	Organism
2	pH Optimum
1	Protein Variants
1	Purification (Commentary)
1	Reaction
3	Reaction Type
4	Reference
4	Source Tissue
4	Specific Activity [micromol/min/mg]
13	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
2	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.13.11.67 - 8'-apo-beta-carotenoid 14',13'-cleaving dioxygenase

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8'-apo-beta-carotenol:O2 oxidoreductase (14',13'-cleaving)

A thiol-dependent enzyme isolated from rat and rabbit. Unlike EC 1.13.11.63, beta-carotene-15,15'-dioxygenase, it is not active towards beta-carotene. The secondary product has not been characterized, but may be (3E,5E)-7-hydroxy-6-methylhepta-3,5-dien-2-one.