1.1.3.46: 4-hydroxymandelate oxidase
This is an abbreviated version!
For detailed information about 4-hydroxymandelate oxidase, go to the full flat file.
Word Map on EC 1.1.3.46
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1.1.3.46
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oxidases
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fmn-dependent
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amycolatopsis
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four-electron
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flavin
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coelicolor
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benzoylformate
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two-electron
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mononucleotide
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vancomycin
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nonribosomal
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orientalis
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chloroeremomycin
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synthesis
- 1.1.3.46
- oxidases
-
fmn-dependent
-
amycolatopsis
-
four-electron
- flavin
- coelicolor
- benzoylformate
-
two-electron
- mononucleotide
- vancomycin
-
nonribosomal
- orientalis
- chloroeremomycin
- synthesis
Reaction
Synonyms
4HmO, fegC, HmO, hydroxymandelate oxidase, L-4-hydroxymandelate oxidase, p-hydroxymandelate oxidase, Sco3228
ECTree
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Crystallization
Crystallization on EC 1.1.3.46 - 4-hydroxymandelate oxidase
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structures of Hmo and its mutants in complex with physiological/nonphysiological substrates, products and inhibitors
structures of wild-type and mutant Y128F with and without substrate. Cofactor FMNox possesses an electrophilic/nucleophilic duality. In the Y128F mutant the active-site perturbation ensemble facilitates the polarization of FMNox to a nucleophilic ylide, which is in a position to act on an alpha-ketoacid, forming an N5-acyl-FMNred dead-end adduct. In four-electron oxidation of mutant Y128F, an intramolecular disproportionation reaction via an N5-alkanol-FMNred C'alpha carbanion intermediate may account for the ThDP/PLP/NADPH-independent oxidative decarboxylation reaction