Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.B51: 3-quinuclidinone reductase (NADPH)

This is an abbreviated version!
For detailed information about 3-quinuclidinone reductase (NADPH), go to the full flat file.

Reaction

(R)-3-quinuclidinol
+
NADP+
=
3-quinuclidinone
 +
NADPH
 +
H+

Synonyms

RrQR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B51 3-quinuclidinone reductase (NADPH)

Engineering

Engineering on EC 1.1.1.B51 - 3-quinuclidinone reductase (NADPH)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
F212A
complete loss of activity
F212L
complete loss of activity
I167A
complete loss of activity
I167V
relative activity for 3-qinuclidinone is 24.5% compared to wild-type enzyme
K185A
complete loss of activity
N173A
relative activity for 3-qinuclidinone is 97.8% compared to wild-type enzyme
Q178A
relative activity for 3-qinuclidinone is 164.5% compared to wild-type enzyme
S166A
complete loss of activity
S168A
relative activity for 3-qinuclidinone is 115.7% compared to wild-type enzyme
Y181A
complete loss of activity
Y181F
complete loss of activity