>Q9NV66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Homo sapiens|Swiss-Prot
MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>Q57705|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)|Swiss-Prot
MIPEEIYKILRKQRYQIDGHTAVKLCGWVRKKMLEDKNCYKSKFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPRDIGIDISQIKEPKWEEPEVVYEKILAMHKRIIMGYAGVLDRVGEK
KFKEALEPKHVAISLSGEPTLYPYLDELIKIFHKNGFTTFVVSNGILTDVIEKIEPTQLY
ISLDAYDLDSYRRICGGKKEYWESILNTLDILKEKKRTCIRTTLIRGYNDDILKFVELYE
RADVHFIELKSYMHVGYSQKRLKKEDMLQHDEILKLAKMLDENSSYKLIDDSEDSRVALL
QNENRKINPKL
>Q8BJM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mus musculus|Swiss-Prot
MGPLDVWDLSPLLSLWMNRFYIYMGCALGLTLCICVQIIKKQVTRSQEKRVPGAPDSSLS
PQKKQTHVSGVKIFYGSQTGTAKGFAVVLAKAVTSLDLPVAIINLKEYDPDDSLIGEITS
KTVCAFLVATYTDGCPTESAEWFCKWLEESANDFRFGKTYLKGLRYAVFGLGDSAYRSHF
NKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQRGEK
KACGGNCKRGKCESAQHGPGEARPHPQGELHPGDAEEEEPCESSSEDELGTQDYQSLTSV
VDVEDLGNIMNPVKREKREKSHQDGKAAMQRNPEKTEDGEGRAMITPALREALTKQGYQL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMY
PEINRLLKLLHQHGISSFLVTNAQFPEEIRKLTPVTQLYVSVDASTRDGLKKIDRPLFKD
FWQRFLDSLKALSAKQQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYCGES
AASSLTMANVPWHEEVVRFVRELVDLLPDYEVACEHEHSNCLLIGHKKFKIDGEWWTWIN
YSRFQELVLQYEESGGSKTFSSRDYMARTPQWALFGARERGFDPKDTRYQRKNKTKDISG
C
>Q8H8N3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza sativa subsp. japonica|Swiss-Prot
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>Q5REF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pongo abelii|Swiss-Prot
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGRNLQEKSVPKAAQD
LMTNGYVSLQEKDVFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEAAIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQRGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGKDHQSLNSIVDVEDLGKIMDHVKKEKREKEQREEKSGLFRNMGRNEDGEIRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWRRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVCELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>Q9V1F9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus abyssi (strain GE5 / Orsay)|Swiss-Prot
MREMITIKPGKITVQANPNMPEEVANLFRKQHYEIVGRHSGVKLCHWLKKSLTEGRFCYK
QKFYGIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTELPQPWDDPEFIVEESIKAQRK
LLIGYKGNPKVDKKKFEEAWEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGT
VPERLEEMIKEDKLPTQLYVSITAPDIETYNSVNIPMIPDGWERIMRFLELMRDLPTRTV
VRLTLVKGENMHSPEKYAKLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHQDIREFAE
ALVKHLPGYHIEDEYEPSRVVLIMRDDVDPQGTGVNGRFIKH
>O59412|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)|Swiss-Prot
MMEMITIKPGKITVQANPNMPKEVAELFRKQHYEIVGRHSGVKLCHWLKKSLTEGRFCYK
QKFYGIHSHRCLQMTPVLAWCTHNCIFCWRPMENFLGTELPQPWDDPAFIVEESIKAQRK
LLIGYKGNPKVDKKKFEEAWNPTHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGT
IPERLEEMIKEDKLPTQLYVSITAPDIETYNSVNIPMIPDGWERILRFLELMRDLPTRTV
VRLTLVKGENMHSPEKYAKLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHQDIREFAE
ALVKHLPGYHIEDEYEPSRVVLIMRDDVDPQGTGVEGRFIKH
>O59761|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Schizosaccharomyces pombe (strain 972 / ATCC 24843)|Swiss-Prot
MGYSLGYIGEHWEEYRAVLYIVLLLPVLIHFLIRRKTQLSNSDKSSEKKDEVKKQREVKR
FKRVGKRGKIGSPSSSIRKQNDTIDWKNSPLCVFYSTLGGTAERYAKQVHEELSSLLQRD
DIQLLNLDYVDLSEYFVSCPENAIYLVVLPSYEIESSIDYYLSSLQESFSDFRVPKDPLH
GLSGYAVFGLGDMENYPGDKFCYQAIQADKWIKKLGARRLAPLGVVNTQLAPTAQIDALL
QWTRSVAECLKNGTLLKIGNTDSLSSDVMDVEDMGSMMAKAKAEAALPVGTKEMVSTESP
TYKALTKQGYSVVGSHSGVKICRWTKSAMRGRGFCYKYSFYGIRSHLCMEATPSLACANK
CTFCWRHGTNPVGTSWRWKVDPPEMILQGILKAHYAKLKLMKGVPGVLPDRYEEASRVRH
CALSLVGEPIFYPYINEFVSMLHEREISSFLVTNAQHPEALRNMGMVTQLYVSVDASTKQ
SLKSVDRPLFKDFWERMLTCLEILREKRQRTVYRMTLVKGFNMEQIKEYTELIRLGVPCF
IEVKGVTYSGNSDQSPLTMKNVPYYEEVIDFVKKLIEYIDIHLQDLGVRYEIAAEHAHSC
SILVAQTAFKKDGHWHTHIDYPKFFELIRTKKDFGPFDYMASTPDFAMFGNGGFSPEDTR
FHRKKKTQTSKPISATISETATISEAAA
>Q2KHP8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xenopus laevis|Swiss-Prot
MDKSTDAWDFAYTHLMFLWLNRFYIYSCAAIGITVWVCSHFIMARKKHQNETVCNGSLLL
KTKALKSDSLTSNKEQKVYVAGVKIFYGSQTGTSKGFAHLLAEEVTLLGLPVELINMKEY
DPDDNLVEETTSKNICVFLVATYTDGKPPESAEWFCKWLEEASNDFRFGKTYLKGMRYAV
FGLGNSVYSTHYNTVGKNIDKWLWMLSANRVMTRAEGDCNVVKSKHGSIESDFEAWKRKF
LNRLKALLSGEKKPCSGKCKKGKCKSKKKSSIESVEEEEEEEEKHSEHEDTEDDTFETSS
DSEPEEHGEPGSGLIDVEDLGKAMSNMKKSKREHDSNTELGKSLQGDEAKEKEEPREMIT
PALQEALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILEEAILNHQNMIKQFKGVPGVKPERFEEGLAV
KHCALSLVGEPIMYPEINTFLRLLHNQHISSFLVTNAQFPEEIRSLEPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFIDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLVALGLP
DFIEVKGVTYCGESSASNLTMANVPWHEEVIRFVEELVDLLPDYEVACEHEHSNCMLIAH
KKFKINGEWCTWIDYERFQELIQAFGESKGSRTFTALDYVAKTPEWALFGSRERGFDPLD
KRFQRKNKTKDISGC
>Q08960|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain ATCC 204508 / S288c)|Swiss-Prot
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>Q6NUM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Homo sapiens|Swiss-Prot
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIE
ANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHRCMETTPSLACANKCVFCW
WHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQQFLDSLKALAVKQQRTVYRLMLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGG
EWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKN
KSKAISGC
>Q8RXN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabidopsis thaliana|Swiss-Prot
MSTTSSVRVRLAFVALLSATTFYCIHKYRRLKHLKNLSLNPSSTLKASRGKIFFISQTGT
AKALAQRLHELCASNDIAFDIVDPHSYEPEDLPKETLVLFIASTWDGGKPPKNGEFLVNW
LGESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEGD
VDDGELDRAFQDWCDGVIRVLKGGSAQETNGVSQQIGAVEDDLEYYDSTDEEDEDNDADG
GIVDLEDIAGKAPSKRNGVVKVTKVDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSV
IVKGALDLHKNMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGR
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
TDVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTEKFKVDGKWFTWIDYEKFHDLVASG
EPFTSTDYMAQTPSWAVYGAQEGGFDPGQLRYKKERNHPPKPQAVLA
>Q08C92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Danio rerio|Swiss-Prot
MSGVLNDVRDYTEGYLQVLWQNRLYVYSTAAVLIGVWFTVNMLFKKKKMVHPVSPLASKS
VKKQEPASEAKKVIYVSGVKVFYGSQTGTAKGFAKELAEDVIAQGIQCEVIDMKDFDPED
RLAEECTSKIICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLG
NSVYVGHFNTVSKSIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQVWKGKFLNRL
QALAKGEKKACSGNCKKASCKNKKKHKEEAEDNHSLAEKNNSEEELMESSSDEESSSEDE
KSHGSVIDMEDLGNVMNHMKKAKQRMEEDEEDSQRVKQNGERKSECEEERREMITPALRD
SLTKQGYKLIGSHSGVKLRRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAEKIIQEAMENHRNMIRQFRGVPGVRPERFEEGLTVKHCAL
SLVGEPIMYPEINSFLKLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEV
KGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLANHKFKV
DGEWWTWIDYERFQELIQQYEESGGTKNFSAMDYMAKTPSWAVFGAGERGFDPTDTRFQR
KNKTKDISGC
>A0A842WHA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MDKSSSKFSFSEKVIDEFLKKQYGIVGSHSAVQICGWTKRMLRGKGACYKQKFYGADCAS
CAQMSPAAAWCSQNCIFCWRPMEWMDFRQMEEEEVDSPREIIEGTVAAKRKLVSGLGGAE
DVDEGLFRRVLDSFPAHWAISLSGEPTLYPRLPELIKELKGNPEVKTVFLVTNGQEPEML
LRLKEEGALPTQLYISVDAAEKETFEKVNVPVYSDGWERLNRALEMIADFPCRRVLRFTV
IKGVNDLEGMLPLYGKMLEKSGADFIEVKAYMWLGYSRRRLGEENMPSHEYVRELCGKLL
DFLPGYSFEDEDEKSRIVLLKSKKSKYDNIIGSVEG
>A0A6P4TUS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panthera pardus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDQQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVTLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGLANFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A0E3MAT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharolobus solfataricus|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHRKAVSG
YLGRNDVSIQKVKDAMKPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAKEFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKILGQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWNWSTIDMEDDMSGEYKEAEQGCTEGS
T
>A0A7R9LP07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oppiella nova|TrEMBL
TCRILYATQTGTSRRLSQQLMTYLSQEFNEDITHKNITITLNAINEYDAEERLVSDAKNN
TTLIIIMSTYSSGSSAPDGQWFCKWLQDFANDFRVDKSSLKGLSFAIFGVGDKAYGEDFC
LVSKDMDRWLKQLEAIPVVSTQLSDVSDSVGFDKQFKEWMNGLSTNLSNNSVISSEIDSQ
EDMEEEDQLNESANKIVDIEDIVTKKSKLESNGVVKDMITPELRRELTKQGYKLIGSHSG
VKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVWKDVLFRRQSNGSQTN
GQSKTCRILYATQTGTSRRLSQQLMTYLSQEFNEDITHKNITITLNAINEYDAEERLVSD
AKNNTTLIIIMSTYSSGSSAPDGQWFCKWLQDFANDFRVDKSSLKGLSFAIFGVGDKAYG
EDFCLVSKDMDRWLKQLEAIPVVSTQLSDVSDSVGFDKQFKEWMNGLSTNLSNNSVISSE
IDSQEDMEEEDPLNESANKIVDIEDIVTKKSKLESNSVVKDMITPELRRELTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHQTNPVGT
EWKWSLDNPELVFSGALSNHYKMINEFKGVPGVVAERLKEAMEVKHCALSLVGEPIMYPH
INSFVRMLHNKSISTFLVTNAQFPDAIKQLDPVTQLYVSVDASSKQSLKRIDRPLFRDFW
ERFTGSLTALSDKGQRTVYRLTLVKSYNVEELEGYAYLVGLGNPDFIEIKGVTYCGTSKD
SHITMANIPFHEEVVNFSVDLLKHLNSGCESDSKARYGMACEHKHSNCVLIANTKFLVDN
RWHTWIDYNAFARLMQEYYRSDGTKTFSSLDYIEETPDWALWGSQERGFDPNDTRFYRKA
KE
>A0A497R2X3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Heimdallarchaeota archaeon|TrEMBL
MHPIIKERLKKQGYQLYGKQVAVKKCLWTHKYLKEEQYCYKNAYGIESHRCIQATPTLLC
THQCTFCWRLQEKDVGLKPVWNVPDSEFDSPEEVYKGLLWGWKRAISGYKPIVPKELFDQ
AMDPQHVALSLAGEPTLYPFLTELLELLHAKGLSTFLVSNGTMPESISKMITTGVRPTQL
YITIPAPNKKDYLHVCKPIIQNGWDRLNKSLELLGKLGGRTVTRLTMAKELNMKNPVEYV
ALIKKAHPAFIEIKGYVHVGFSQYRVTRGNMPFHEEIRAFANKILEGLPEYKLVYEMEDS
KVVILSNDKQPLKIDFQKIGKKEEELTKKS
>A0A497Q9M5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPNELKTRLEKQGYHLLGDSGRAAFKACQWQRKSLVFGDVCYKEKFYGIQSHRCLQMTPV
VDKCTQNCEFCWRVIPSDVGVGWNQTSVSREDVMEPASLLDSVLVANLRSLGGYNPEVDK
RVSMDKYLEAREPKHLAISLAGEPTLYPMIGELIDEAHSRGMTTFLVTNGTKPEVLKSMT
LPTQLYVTLAAPDEDVYRTLCRPGIRGGWERIMESQDLLGSLKTRTVNRLTMVSKRNMDN
PRGYSKLILSGEPDFVEVKGYMHLGSARGRLSSENAPSHRAIRAFAKAISALTGYYLSDE
QPESRVVLLSRSRHVERLNTN
>A0A2K2BPW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Populus trichocarpa|TrEMBL
MPLTSTPARLTLLALLSATTIYCFYKSRRLKKISLNPNPNKPKLFFISQTGTSKTLAHRL
HNLLASNNLHFDLIDPQNYEPEDLFKEKLVIIIASTWEDGKPPQNAKFFANWLAESADDF
RVGSLMLSECKFAVFGVGSRAYGETFNAVAKDFSRRLRDLGAKEVVGVGEGDVDGGELDG
VFEEWSGRLARVLKGESVENGEVCGNGVVVIDESDDDEDDGGVESDIIDLEDIAGKGPSR
RSLAVAQSNGKLNGENGKLNGQKEMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLRG
RGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAI
DLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHRRQISTFL
VTNAQFPEKILMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLKEKQQRT
VYRLTLVKGWNTEDLDAYFNLFSVGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKAF
SEAMALKSKGEYEVACEHVHSCCVLLAKTEKFKVDGQWFTWIDYDKFHDLVASGKPFDSK
DYMAATPSWAVYGADEGGFDPDQSRYRKERHHKTNH
>A8IUI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chlamydomonas reinhardtii|TrEMBL
MDVLASLYTFGQIFSVTVIDAAAYEPEQLLTEPRDTLVVLVVSTYEGGTPPPSAGFFCSW
LEDAASDFRLGAGALGGLRTAVWGAGNSLYGAHYNAVARRLEAQLLDLGARRFRPLGLGD
EDAGDLRTQFATWAEALVAKLMLNALIRGSLTKQGYKIIGSHSGVKMCRWTKSMLRGRGG
CYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKTWKWKMDPPDVIVDTALDLH
CRMVREYSGVPGVKPEAVAAGLAPRHCALSLVGEPIMYPEINALVGRLHARGLSTFLVTN
AQFPDRIQQLSPVTQLYVSVDAATPASLKAVDRPLFADYWERFTACLTALRDKRQRTVYR
LTLVKGWNMEEVADYARLVDLGRPDFIEIKGVTYCGSGGASSLTMANVPYHADVVAFGEA
ICQARGGEYGLACEHAHSCCILLARVDKFKAATSALRTTCCPHPPGPHSGRRRRASTRAR
>A0A8B9K0E6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
MTLKKKKTVLTSSPPLSKSEKKKEKLPEKEKVIHVEGVRIFYGSQTGTAKGFARELADDA
RATGFHSEVFDMKDYDPDDRLSDECTSKMICVFLVATYTDGKPTENAEWFCKWLEEASTD
FRYGKTYLKGMRYAVFGLGNSEYVGHYNTVGKNVDKWLWALSASRVLSRGEGDCNVVKSR
NGSVQADFQAWKAKFLTRLQALARGEKKACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSE
KQSEEESQRGKLSKLNGVMKTEGEEEAREMITPALREALTKQGTALLIDLISKMLLCVFN
QSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEK
ILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINAFLRLLHQR
HISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALG
EKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWH
EEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGEWWTWIDYERFQELIQRYED
SGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNKTKDISGC
>A0A3L6TS15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panicum miliaceum|TrEMBL
MPPPFPTATTATSHLALLFLLSSSSSLFFLYKSIRLRCKPSPATGPARTTIPTLLYASAT
GTSKTLAARLSARLTAHGGVLVSAADATSFDPDDLPSVPLLLLLVPTHDGGAPPPSAAFL
ARWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVEVVPLG
EGDVDGGDLEAVFEEWSGKVLRVVKGEELNEGVEGESDGLDELELEGEESDVDDEEEAVS
GEIDMEDIAGKAPARRQNGKVEGGLTNGGQNSVKEMVTPIIRTSLEKQGYKILGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKM
DDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVD
ELHRRHISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDS
LKFLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLTME
NVPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWYTWIDYDRYHE
LVISGKPFKSQDYMAVTPSWAVYGAEEGGFDPDQSRFKKERRHRTAALKG
>A0A671Q4X9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MVDPISPLLYKSVKNQELSPETEKVLHVSGVKVLYGSQTGTAKGFAKELAGGISAQGIQC
EVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASMDFRYGKTF
LKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQAD
FQAWETKFLKRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSEEELME
SSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIRQFR
GVPGVHPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIR
SLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWN
VDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDY
EIACEHEHSNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTP
SWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A7L4QXQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MSLKEKEELMTIPEIPDFEALLKKQGYSLAGTHSAVKTCLWLGRSMKGEGECYKSRFYGI
ISHCCLQMTPTLRCNQRCLFCWRPTEAEVSFPENWDSPVEIVGSSIKAQQKLISGFGGSA
PRERWEEANQPKHVAISLSGEPTLYPYLPELVEEYEKQGFSTFIVSNGTVPDIMERIEPS
QLYMSLDAPDRETYEKVCKPKSDDLWDNINRSLEILGKKDNRKAIRITLVKGVNMIDPAG
YARLIEIANPDYIEVKAYMHLGFSRGRLPREAMPSHEEVVSFAKELAEHLGYSIADEVEI
SRIALLSKDGKVSCLY
>A0A533WBT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLIEERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLDMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRIVVLQNQKRFMDRWIAAYANTN
>I7KCZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus bourgensis (strain ATCC 43281 / DSM 3045 / OCM 15 / MS2)|TrEMBL
MHSEACKALRRQGYQFVSPSSSAAVKPCMWNKRALRGGEMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVVEEEECPPAEIIGNLRRLQKRALSGYKVSPYVTPERFAEALR
PTMVAISLSGEPTCYSHLPELIDGLNAEGYTTFLVSNGTRPDVLARCRPYQVYVSLDAPD
RETYLGLCRPREDYWDLVQESLAGLAGRRSAIRTTVVRGYNDFAPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRDQMPEHRDVRAFAAKIADHCDYFIKDESPVSRVVCLERNV
>T0KI57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum gloeosporioides (strain Cg-14)|TrEMBL
MASPLDRPGILSVLNNFHDVWQEIRIPVILFTAFGLLVLRFYLHSVEEKDELKAFPKALN
REKPESKPLPKPIDEKKDAKPSPVVEAKAPKSNGPKRIKGGLVKRPSEELKDGEVLARTV
RPLIFFSSITANTPKIAKDYAERLEKELEKVTADTGCSFNTPEVLDLAEIDFDDYFITPP
KSEDPVELFYMFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREG
WPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYVERLSEWSEGVVDVLGMLAK
TGSLGEGLPGSGAPEESDDESAAEDDDEVLIEEDAKPEKLKSRKNIDDVEDLGRIMKSSN
PDADTKPAAAPIAVDFTTYGKSASAPKKTPTNAAKEMVPKNSPTYASLTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINE
FLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERF
QRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYCGTSTA
SNAGLSMSNVPFYWEVAEFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKDGKWH
PRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A663EQ07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aquila chrysaetos chrysaetos|TrEMBL
MDTWNFYTCLVSLWLHRLYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASFEGIED
KVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDYDPDD
CLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFGLG
NSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRL
QALCRGEKKPCSGKCKKGKCKSPGKQSKDCSDHEHGASEYENTEAEELFETSSDEEADGE
EAGGTNSVIDVEDLGSIMSHMKKAKRERELEEGDTGTSLTHKNAGRKEEGEKREMITPAL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKV
KGPEKERKQIAT
>A0A7N0UPF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kalanchoe fedtschenkoi|TrEMBL
MSFSSPAASTAAHLTLLTVLSAATIYCFYKSRRLKFASRNPKPSLPPATGKLFFISQTGT
SKALGRRLLNLLTSNGLVFDLVDPKDYEPEDLCKETLVLIVASSWEDGKPPPGARFFANW
LEESADDFRVGSLLLSKCRFSVFGVGSRSYGEAFNAVSRHFSKWMRALGAEELFPVYEGD
VDGGDLDEVFDSWSGKVIQRLKGGLVENGDARDFSVVCHSDEEFVDGFLDDDDDDYIDGE
ENADVGVVDLEDLAGRGPTRKLGQEVSSNGRVNGVKEMVTPIIRASLEKQGYKIIGSHSG
VKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRW
KIDDPLEIVNTAIDLHTKMIKQMKGVPGVKVKRLAEGLSPRHCALSLVGEPIMYPEINTL
VDELHRRRISTFLVTNAQFPERIMLLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFV
DSLTALKNKQQRTVYRLTLVKGWNTEDIDAYFNLFSIGKPDFVEIKGVTYCGSSATSKLT
MENVPWHADVKAFSEALATKSNGEYEVACEHVHSCCVLLAKVDKFKVNEKWHTWIDYEKF
HDLVASGRPFTSTDYMAATPSWAVYGADEGGFDPDHTRYKKERHHKPKN
>A0A7J4FZR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Geothermarchaeota archaeon|TrEMBL
MSSREVIKIPERIVNQLLNAHYGVYNHSTVEICHWTKKSLKNQGVCYKRVFYGIDSHRCV
EFSPAGMMCTMKCIFCWRPMEFMKKVDMAFEEVDDPIDIMEGLMKERSRLMSGYPGMPNV
DFRRLEESKEPTHYAISLSGEPTLYPRLPELVRYLKSLPSTRSVYIVSNGLQPDMIKRLM
DEDALPTQLYISMSAPNEEVMYRVDKPLYKDAWSRYIRTLELLSQADTRTVIRMTMIKDV
NALDEYIPEYVGLLEIANPNFIEVKSYMHLGYSTKRLKKSNMMSHEEIRRYARKILRRLK
GFRYMDEYPPSRIAVLQNMVRYVDRWIN
>A0A319D3R8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus uvarum CBS 121591|TrEMBL
MAEFAVDEGLLAFWHTYRLPLLLALVAAFTFIRFFRTLQPKSRTATASSIPPSPRSLSPE
KSEKLAIGYDKEITKVEKSAIQTIAEREKAPKSASGPKRVSGKKPSKVAGRRTGSDQNQQ
PLSFIQPIIFYASLTATTEKYAQVLLEDLRAAAQLRADPENRERAILPPQIQDLSYVDFD
DYFAAAPKPPSNSPGTRYVYCLLIPSYNIDTILNTFLGHLDETHNDFRIDTAPLSSLAGY
AVFGFGDKEGWPTEEEGYCYQAKELDRWMAKLTGRKRAYPLGFGDVKGDPEAALKEWSHG
LQDILGDILENGGLGEGVPGSGDPLESDEEDLDEEGSDDSSKKNRKRNKAQDVVDLEDIK
FSADSGSGTPIPVDFTTAGASPASAIQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVD
SPDLIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFLDM
LHSEHISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCL
DILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAG
LTMQNVPFYEEIQEFVTSLNKELERRGLKYGLAAEHAHSCCALIASERFYVNGKWHSRID
YDRFFELLEKEKADGTPFKPEDYMSETLEWALWGNGGFDPNDERVYKKGKKKGLQAAAAA
QD
>A0A2N3N8L9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lomentospora prolificans|TrEMBL
MASQGWLSESGSTLDRVSNGRLLAGGTPSSDNILELWHSYRTPILLSVFVSLVGLRAYLH
ATEEHEDLVVLPKLYENEKALSTKTDETPSTGTKTKKSPSPSRERRKTGPKRIKGGLNKA
KAASQTPVEPNANQSLNREAQVLIFYSSITTNTARIANEFKAKLDAAVKKLPGIPDRQFL
EAEVLDLAEIDFDDYFIAPPASKQGIDLFYLILLPSYNIDTINDTFLEHLKETHYDFRID
TGSLSALLGYSVFGFGDREGWPDENEGYCFQAKEVDKWMARLTGRKRAYPVGMADIKRDY
NERLAEWTGGVTDILGQVLRTGSLGEGLPGSGNAVESDDESGSDVDDEYDDGETLVGSGS
GSSSADLGDVEDLGKIVEGGLPKESQTKAPLAVDFTTYGKSVVPLRRKAPVQTVKEMVPK
NSPTYASLTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMESTPSLSC
SNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGIKANHYQKIKVLRGMAGVRAERYAEAMR
IRHCALSLVGEPIFYPHINEFLALLHGDRISSFLVCNAQHPDQLAALKAVTQLYVSIDAS
NKESLRKIDRPLHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNIDDEVDGYADLVE
RGLPCFIEIKGVTFCGTSTSANHGLRMTNVPFYWEVCEFVKALEKRLNEKGLGYGIAAEH
AHSCCVLIASDRFRVEGKWHTRIDYDRFFELLEERGADGDWKPEDYMGEATPEWATWGNG
GFDPRDERVDRKGRKIEA
>A0A328SLW5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. rholeuAM130|TrEMBL
MLISETKKQDMEKKGYRFAGKHLHSGNKICHWTRKSIVDDGVCYKEEFYGIKSHRCLQMS
PAIPYCQHKCLFCWRDTEITKTSWDTDDYDDPGTIIDDCIANQKQLLCGFFGNENANPKK
LEECLKPNNAAISLAGEPLLYPEINQLLREFEKKDFTTFLVSNGERPDLLKKLEDEEPTQ
LYISLDAPNRDVYKRVCIPQVENGWEKLNESLELLSTLDTRKVLRITSVNELNMLNTDEY
ARIIDRTDIDYVEIKAYMFVGDSRNRLKWENMPTTKQLHDFAYDVATKAGLDVLSEVEKS
RVLLLGDKLPTKYNN
>V5TI42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula hispanica N601|TrEMBL
MKPTAMSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQ
MTPVVKCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPRE
VFDQAMEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLY
VSVDAADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYA
AMCDRADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDS
RVAMLAEDENTWVPKLEKSSEFWEQDSLVEY
>A0A1B8BXA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. WSF 3629|TrEMBL
MANNEYFGADIASHASENYFMALWHTYRIPLILTLLAVLLITRTVLHLKVGREKIVYTPP
PTPSEKAPVVANPQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLRDEPANKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLAPIAHDLAELEDYDEYFLGLPK
PEDASQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAMFGFGDR
EGWPTEAEGFCSQATEVDRWLAKLTARKRAFPLGMGDTKVDAQERLEEWRQGVEDVLQNL
GKTGNLGEGVVGSGDADESDVEDAEEDDVEVQSDGAVKLKRKSKKNVTSSMDDVEDIGRI
LQKGQTESEDQDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
GAAGLTMQNVPFYEEVCAFVLALTAALEKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEG
EEVEKEEKPVLVEI
>A0A8H7YH64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Histoplasma ohiense|TrEMBL
MAGDVLQIFAQRFLTSWHRYRIPIFFLAAVVSIVIWLSTRYHKRNTPLSDSLSPCQSEKQ
NQNDKAEPCRVESPSKNDPAAAFYPTSDHSGSSIESQVRQAKQSANGPKRVHGSKPVKRC
ANNRTNPGELSRDINIQPMVFYVSLTGSTEAYAKSFCHRLQKATHALIENHSKTAILTPQ
LHDLSYIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRID
TSSLSGLAGYSVFGFGDREGWPSEEEGFCSQARDVDRWMAKLTGKKRAYPLGMADVKGDN
TQMVLNDWCDGLSGIMFDLISSGGLGEGFPGSGDPIESDEEDIRDSEENDENGQSRRNKR
KEEQIVDLEDIKFGIPEGKGTSTDRQLLPIDFTTHSHPQASKPVSQPQLEMVPTSSPTFT
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWKVDPPGLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCF
VEVKGVTFCGTSTSASAGLTMQNVPFYEEVVAFVVALNAELTRRGLGYGIAAEHNHSCCV
LLASNRFYVNDRWHTRIDYDKFFTLLEKEKNNGISFRPEDYMRETDEWALWGNGGFDPND
TRVYTRGKNKAKLNAALKASEQNATSVEG
>A0A317YG62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zea mays|TrEMBL
MTVARGPPGRPSSGLLGCWRRRPALGFGAKVGIAIALGLSFAIIWTSISPTSSSQQISTE
RSSFAAEVAAPPTASHNRAAAVGDSGSGGHAHRKPRPVPRSHKKRHPAPSGSHSHPHRSN
VTSSPDTTAAKDDHSEPALVTDPEPKEEQGPDMEMEPEQEAELPMPELGGDNSGKAPAEE
EEEKPPQLELEDEPNEVDGEEDDPEAAKRKAPSKKRKLPPLFSPGARYHWKLCGANSGYH
YIPCVDFDGDGRQRHHERSCQRSPVTCLVSLPKEYKQPAPWPERKDKVWYGNVGHPRLSN
YVKGHNWLNHSGEYLMFPPDEWEFKGSARHYVESIDEMAPDIDWGKNIRIILDVGCKSAG
FGIALLEKDVITLSLGLTNDQTDLAQVALERGIPATVGSLGSRRLPFPSGAFDAIHCGEC
NIPWHSNGGKLLLEINRILRPGGYFIISSRSADLESEEGISASMTALCWNAIAYNSDDVS
EAGVKIFQRPVSNEVYDLRAKKDPPFCKEEQNKASAWYTNIKHCLHKAPVGIEERGSDWP
EEWPKRLESFPEWLGETETRVASDHNHWKAVVEKSYLDGLGIDWSNIRNIMDMRAVYGGF
AAALASKKVWVMNVVPVHAADTLPIIYERGLIGVYHDWCEPFSTYPRSYDLLHADHLFSR
LKIRCKQPVSIVVEMDRILRPGGWAIIRDKLEILDPLETILKSLHWEIVMTFRKDKEVHL
LLLVIPTHDGGAPPPSAAFLSRWLEESAADFRAGALLLSGLRFAVFGVGSRSYGETFNAA
ARNFSRWLRALGAVEVVPLGEGDIDSGDLEAVFEEWNRRVLRVVKGEEVSYGANEKSNGL
DELELEGEDWDDDDEEMVDAEVDMEDIAGKAPARRKNGNLEGVLANGVHNGVKDMVTPII
RTSLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGKSWKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLDEGLSPRHC
ALSLVGEPIMYPEINALVDELHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKES
LKAVDRPLFSDFWERFLDSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLDLGQPDFI
EIKGVTYCGSSATSKLTMENVPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVD
KFKINGKWHTWIDYDRFHELVTSGKPFKSRDYMAMTPSWAVYGAEEGGFDPDQSRFKKER
RHGTAALRS
>A0A8J8VUY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp. b2|TrEMBL
MSCSGEIIDGEEQLIQIKPAISAQLKKAKYGVSDHSTVELCHWTKKSFKHEGNCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLQTTKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYKSFLKINKPKYDDSWERWNRTLGMLKHLNTRTVL
RITLIRGYNDQKDMIPAFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKQFS
EQIAKQSKIFSVMDESFVSRISILQNNERFIDRWIPSYANTN
>A0A7J5YD42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dissostichus mawsoni|TrEMBL
MRTSRDPRPLVSQRISSSISLKQPGSSSKSSLSTTCSSGFSFSFSLLASLAGSTRRSLMW
ALWISMDSFSCRITSRAWEQPGSQNALSPSESYLLSVWHHRLYLYSAAALLFGFWFLLKV
ALNKKSFSKDVGPLVSKAVKRSEDSDAVVHLSGVKIFYGSQTGTAKGFAKELSGEVKTLG
IPAEVIDIKDYDPDDQLSDECTNMSVCVFLVATYTDGTPTVNAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRERATHSGRLPGWKVK
FLTRLQALAKREKKSCSGSSKNGSSCKNKKKEQEEDEAAPVPQDNSSEEDLMESSSDEEE
SGLQDEKTSGSVVDMEDLGNIMNSVKRAKSKEEGGDGLMVKLSKVNGLKKIEDEAERREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHNTNPVGTEWRWKMDPAEKILEDALEKHQTMIRQFRGVPGVKPERYEEGL
AVKHCALSLVGEPIMYPEINTFIRLLHTHHISSFLVTNAQFPEEIRSLVPVTQLYVSVDA
STKDSLKRIDRPLFKDFWPRFLDSLRALGEKTEDGVQADAVKAWNVEEMQAYSELSLGQP
DFIEVKGVTYCGDSPASTLTMANVPWHQEVVTFVQELADMLPQYEIACEHEHSNCLLIAH
TKFKVEGEWWTWIDYERFQELVQAQEESGGQQGFSALDYMAKTPSWALFGATEQGFEPVD
TRFHRRNKTKDISGC
>A0A267GGH3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
QSASKMSHWDLTVHISRALQNSSALSYSLLLAASVVGAWILFQRRGRQGHVISASSVKKA
VLSSSSQMSLRSPTTRKAMLPTTSCTSTANGSVDETFNKVRVFYASQLGRAKHFATLLRD
ELAGVLKQQKQQQQQSQCCNGGDGEACKSTTVSSSDSAGIELIDLANYDPEESLHKESPD
TLCYFLLPTYEGGSSPNTGAWFCKWLAEAAEDWRVERGHLSGLRFIVIGLGNSLYAENYN
LIAKRVDEQLTQLSGTRLRPPVLLDENVASATGHGGQEADFQAALQSQLLDPLVSKKKKS
ACCSEATGNSACCQGAEAASDVAEDHSDVDSDHLDEEDQDGLVDVEDIGGVLSSATRSNQ
KQKLRQEATTRRAMVTPLVRKSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYG
IASHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWLEDPPDEILSGALDAHRRMIREFR
GVPGVMPERISEGMQPRHCALSLVGEPIMYPRINQLLHLLHTSGISSFLVTNAQFPEAMR
QLPPVTQLYVSVDAATPDSLKRIDRPLFKDFWQRFIDCLRAMRDCGQRTVYRLTLVKAWN
TEEVQQYAKLVDLGCPDFIEVKGVTFCGDSKASQLTMGNVPWHKEVVQFSQALADSLANQ
YDIACEHEHSNCVLLANKRKFLVNNRWHTWIDYDRFEQLYGRFVETGQRFNAADYMAETP
EWAVYGSAEQGFDPNETRFRRRAAAAAAAASGDY
>A0A7K8F3S5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Struthidea cinerea|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVAQFTTTRTKRKVTEPVSTFLRE
DPKILDKLGNGCASPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMG
DYDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRY
AVFGLGNSAYADHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKA
KFLTRLQALCKGEKKPCSGKCEKGKCKSSGKQSKESSDHEHGMSEHENTEAEELFETSSE
EEAGGTDSVVDVEDLGDIMGHMKKAKVLLLEGVWNAHGVHHFRYQPGCVVDQFLQAKLNC
LTIFALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKH
CALSLVGEPIMYPQINRFVRLLHRHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKE
SLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDF
IEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSK
FQVDGEWRTWIDYGRFQELVREHERSGGSRTFSAAEYTARTPSWALFGARERGFDPLDVR
FQRKNKARDISGC
>A0A2A3T5C8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGEVIEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEDIITKLMAERKKLIM
GHYGDPNQDKKKLDESLLPSHYSISLSGEPTMYPKLPXLIKXLKSLEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYKSFLKINRPRYDDSWERWNRTLKMLSTLXTRTVL
RITLIRGYNDDEEMIPXFASLLXXSNTHFVEIKSYMHIGRSTNRLEHSDMLEMSEVRSFA
NKLAQENSXFTVMDESXISRIVILQNKKRFVDRFIPACC
>G7XKV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus kawachii (strain NBRC 4308)|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPENRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKRNKNQSVVDLEDIKFNSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAVETQG
>A0A836BEQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGEVVQEEELIQIKPGVLQQLKKAKYGVADHSTVQLCHWTKKSFKNEGDCYKHKFYG
ISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPERVTEPEEILIKLMEERRKLIMG
HYGDIKSDKQKLDESLFPSHYSISLSGEPTMYPKLPELIKYLKSLKATKSTFLVTNGQEP
DMIKRLSDEGALPTQLYLSTNAADYESFLKINRPRYKDSWERWNTTLEMLKELDTRTVLR
ITLIRNYNTSDEMIPALASMIKRSSPHFIEVKSYMHIGRSTNRLERTHMLEFDEVKRFAS
ELASQSKIFSVMDESDISRIVVLQNQERFIDRWIPAYLETN
>A0A2Y9JA12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Enhydra lutris kenyoni|TrEMBL
MDPAGAWDSASPWVSLWTNRFYVYVGLACGISLWICFQIVIRRRDKSSQEKSVPKASRDL
GTEGSISLQRKEVSVSGVKIFYGSQTGTAKGFAASLAEAVTSLDLPVAVIDLKDYDPDDH
LVEEVTSKNVCAFMVATYTDGRPTESAVWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYARHFNKVGRNVDKWLWMLGAHRVVARGEGDCDVANSTHGSIEADFRAWKTQFLAQLQ
TLEKGEKKPCEGSCERGQCGSSAEEEPFESTSEDESGAKDPPNLNPVVDVEDLGRIVSCV
KREKREKEQQEEKSSLLRSSGKNGPGERRAMITPALREALTKQGYQLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEM
ILKEAIENHQSMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLTLLHEC
KISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTEDRLKKIDRPLFKDFWQRFLDSLKALA
AKPQRTVYRLTLVKAWNGDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWH
EEVVHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKVGGEWWTWIDYDRFQELVREYED
SGGSATFGAQDYTARTPRWAVFGARERGFDPKDTRYQRKNKSKDISGC
>A0A7L4NZC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriaceae archaeon|TrEMBL
MPISDTVIKNLEKKGYRFVGSKRHAAAKVCHWTKKSLLDEGVCYKEKFYGIKSHRCLQMS
PSIPFCHHKCLFCWRDISITSTTWDEEFDDPGDIIDGCIEAQRKLLVGFFGNSQANQNKV
REAQNPNNAAISLAGEPLLYPSINQLLEEYQQRNFTTFLVSNGLSPEKLKNLNPEPTQLY
LSLDAPNPEIYKSICDPQVEKGWEKLKQSLDLLSTFNCRTVIRMTCVKDYNMFHPEEYAQ
IIEGADPDFVEIKAYMYVGSSRDRLKFDHMPKSKDIFEFANSVANLCGRKIVDHAPESRV
VLLA
>W9IMU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum NRRL 32931|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEKKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEAEKDLNRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8C3UM89|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Catharus ustulatus|TrEMBL
MDTWSYFHTCLVSIWLHRFYIYSAVAFGIILWIVLVCLSGFAKALAEAVTSLNLPVETSS
RNICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSAYVDHY
NTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQLQALCKGEK
KPCSGKCKKGKCKSLGKGREELRSHELVMEPEELFETSSEEEAGGTDSVIDVEDLGNIMG
HMKKAKREQELQEGAAGAGRKEEAVRREMITPALREALTKQGEALPRAAGAQLRVLSHRC
MEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIREFKGVSGVK
AARLEEALAVKHCALSLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVT
QLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKSWNVDELKA
YADLISIGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEH
EHSNCLLMAHSKFHVDGEWRTWIDYGRFQELVREHEQSGGSRTFTAAEYTARTPPWALFG
ARERGFDPLDVRFQRKNKARDVSGC
>A0A6A5FP56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perca fluviatilis|TrEMBL
MLMSQKYGCTQHQLQRTVYFNTPLAKMLSFFVIIVLCISRVSTFDTKVSQNARSPSESYL
ISIWQNRLYLYSAAALVFGIWFSLKLVLRKKSFSKDVGPWVYKAVKSNDSPDRDTSVHVS
GVKIFYGSQTGTAKGFAEELSEEVKTLGIPAEVIDIKDYDPDDQLADECTNKSVCVFLVA
TYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDK
WLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFVAWKVRFLKRLLALAKGEKKSCSGNCKT
GGSCKNKRKDGQEKGEEEEEEEKAALQNNSSEEDLIESSSDEEDSGLQDEKNSGSVVDME
DLGKIMNSAKKAKSKEEGRGDGQMVKLSKLNGVKKIEDDGERREMITPALRGALTKQGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNP
VGTEWRWKMDPAEKILQDALEKHQSMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIM
YPEINTFIRLLHSHRISSFLVTNAQFPKEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFK
DFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVTYCGE
SSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLMAHTKFKVDGEWWTWI
DYERFQELVQAHEESGGQQGFSALDYMAKTPSWALFGANEQGFDPADTRFQRRNKTKDIS
GC
>A0A151BGK5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon B23|TrEMBL
MPLPEELRRVYARQGYHFVGRHSAVKTCHWVRKSLTTGGVEHCYKQHFYGVPSHRCLQMT
PSLGRCLQSCLYCWRAKPEDIGVAWDQMHLPREEADDPDLIVESSIEAHRRAISGFGGNP
KVPRELYLEAREPIHAAISLEGEPTLYPRLGELVEAYFNHGFKTVFIVTNGLRPDVIADL
DPEPSQLYVSVSAPDEETYRRTCRPLVGGGWRRLMETLELLNSLSCPTVLRHTLLPKYNM
HSPEGYARLAELSNATYIEPKAAMSVGYARLRFGYEEMAWHSDIRRFAEALAEASGYRIV
DEHPPSSVVLLSQLEKPIRLC
>A0A061FDJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theobroma cacao|TrEMBL
MSPSSLSARLTLLALLSATTFYFLYKSRRRLKPLRQLPINSNPRKGKLFFITQTGTSKAL
AQRLLNLLSSNNIPFDLVDPQNYEPEDLPKESLILIIASTWEDGNPPQGSKFFVNWLAEI
STDFRAGNLLLSSCKFAVFGVGSRVYGETFNAVARNLGKRLRGLGATEMVAVGEGDVDGG
ALESVFKEWSEKVVRVLKGGLVVENENGIVYASDAESFESDDDDNGGGGGEEEIVDLEDI
AGKGPSRKKSVNVAETNGKMDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTA
IDLHTKMIKQMKGVPGVTQERLTEGLTPRHCALSLVGEPIMYPEINMLVDELHRRRISTF
LVTNAQFPDKIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALRDKQQR
TVYRLTLVKGWNTEDADAYSKLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKA
FSEALALKSEGEYEVACEHAHSCCVLLAKTDKFKVNGQWYTWIDYEKFHDLVASGEPFDS
ADYMALTPSWAVYGAEEGGFDPDQSRYRKERHHKSNR
>A0A2D4PYH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Micrurus surinamensis|TrEMBL
MNTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCIQFLNKAKEQNKNRLAELNPSK
TTAAEKEQQDPSFEKVHVAGVKVFYGSQTGTAKRFALVLTKAVASINLPAEIIDMQDYDP
DDCLIDEISSKNICIFLVATYTDGKSTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHGSIEADFEAWKAKLLM
RLQALAKGEQKACSGRCKKGQCRSKSEVSQEAKEQETSEHVEKEEEDFFETTSEEESDIE
NGRGADQVVDVEDLGKVMDQMKKSQKDHQTNGEVPIGVGTQHGRGEDERREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEVIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALS
LVGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEISNLQPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIK
GVTYCGESSASNLTMANVPWHEEVTRFVQELADLLPDYEIASEHEHSNCLLIAHKKFKIE
GKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKERGFDPVDTRFQRK
NKIKDISGC
>A0A673K6E6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
VLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGVCFTMNMLFKKVIKRGFAKELAGDVSAQ
GIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLEEASTDFRY
GKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGS
VQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHSLAEKNNSER
VKLSKQNGVRKSESEEEQREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCGFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHR
NMIRQFKGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNA
QFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRL
TLVKAWNVDELKAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQL
ANLLPDYEIACEHEHSNCLLLAHHKFKVDREWWTWIDYERFQELIQEYEESGGTKSFSAM
DYMAKTPSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>Q8ZZN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)|TrEMBL
MSCEYEALGRYHVLEGPRIKIRASAARALIERHYGVAGHAAVELCKWTKDAIEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLICSNRCVYCWRPTEEFDVISLNERFYMEPEEIVRGVLE
ERRRLLSGYWGHPQGRKRVKEALEPTHWAISLSGEPAMYPKLPELIKLIKSLPSTKSVFL
VTNGQHPEMLRRLIEEDALPTQLYLSTNAPNKELYYRINVPVYNREDAWEKWLESLDIIA
KAPTRTVLRITLIRSLNFDDKYIPEFAQIVKRGNPHFVEVKSYMHLGHSTFRLKREDMLS
HEEVKEWSFKLLKELEKIGARFAYMDDDEPSRIVVLQNLDRYVDRWIVPPGAPI
>A0A5N6SQE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus pseudotamarii|TrEMBL
MAELSLIEGLVTFWHSYRLPILIAIASVAIILKVYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQTRTGESEKPAVAEKSVPKPASGNDAVPKVVSGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTATTERYAQILLEDLRTAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPQPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
NILVDILDNGGLGEGVPGSGDPLESDEEDLDDDENDGNRSKRRNGQDVVDLEDIKMGSDE
QSGSGPVPVDFTTAGKSTAPSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHNEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTTFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A2K1QHR4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaceloma murrayae|TrEMBL
MGFLEGFLALWHAYRLEILIFISISAVGARYYQQRIPPKRRPSHEVDKKYEGSLYVRDGA
KDREYKLPVVASKSTSTAKHDGPKRITGARKSSPGASRMKTSSNGPVSVQPVVFYFSLGG
STEKLAEHLCANLAKMAQTSPSLKQPQLLNLVEIDFDNYFISTPDIDSGVQLLYLLLLPS
YNIDSELVAFISNLAETHNDFRIDTSPLSGLAGYSVFGTGEKEGWPTEAEGFCSQAIEID
KWMARLTGKKRAYPIGTSDIKDAQQSLALWQAGIAEVMDSISAGNGLGDGVPGSGDALES
DEEDADEADQVSLPTSKKRKRITRTITADLEDIRAPSSEPLEVDFTTTSKTSAPKEMVPV
TSPTYKALTKQGYTIVGSHSGVKLCRWTKSALRGRGSCYKYSFYGINSHRCMESTPSLSC
SNKCVFCWRHGTNPVSTTWRWTVDPAPLVFAGIKAGHYQKIKMMRGVPGVLASRFSEAMQ
IRHCALSLVGEPIFYPHINELLSLLHSERISTFLVCNAQHPDQLAALDHVTQLYVSIDAA
TKEGLKKIDRPLHRDYWERFLRCMDILREKRDTQRTVFRLTLVKGFNIDEEVEGYADLVQ
RARPGLVEIKGVTFCGTSTSASAGLTMQNVPFYEEVCEFVEALDRALEKRGLGYGIAAEH
KHSCCVLLAEKARFEREDGWHTLIDYEAFFDCLESGREFGPGDYVGETTPEWALYGNGGF
DPRDVRVDRKGRPKDEEGEERMKAREGLMVEI
>A0A818KH73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTVDLYILAAGSAFTGLVFYFFAGAEWSLWHLFTIPLYTFVFIVFLSLSIIKRFKSSSKP
SESLTKIIPQEKNGITIVFGSVKGNCRTFAQSTYDKLSNELNCQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDGTPPPSAKWFVLHLQEAATDFRVSKNELEKLTYAIFGCGNS
FYDDNFNKVATELDRCLSELGAKQFIPTELADENSGKSIYGGLEGHYSKWSSQLKSAFQS
PKTEKCDCSNENSVNCCQSSTNNDHSIEKKQNGEQSRIESDDDDEGGGCKDGDDDIMDLE
DMGDYMETHSPNKTAKGPPKEMITPIIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVDGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A482Y1N1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema altunense|TrEMBL
MSDSANPGADGANGDATAEGDGGGPAQVSSPEYHSENHTAAQTCGWTANALRGEGKCYKN
IFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVAWDDPEAVVDASIDLQKKLL
SGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRP
EMLRDCDPTQLYVSVDAPERHTFDRVVGAMEDDAWENLLETMHVLAEKDDTRTVLRTTLV
KGENMHDPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPDHEEVVAFAEDVREHM
PEFDEVMGVPASRVALVSKTNDTWVPKLQKGSEFWERDPVTGD
>A0A1J7HMA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lupinus angustifolius|TrEMBL
MSISFSSLPARLTLLALFSATTFYCFYKSRRLRNLKFSLSNRFSNPNPKKPKIVFLSQTG
TSKTLAQRLHELLSSNDVAFDLVDSKSYEPEDLAKETLVLVVASTWEDGKPPSGSNFLAT
WLSETATDFRVGSLLLSRCRFAVFGVGSRAYGETFNAVARDFAAQMKALGAAEIVPMWEG
DVDGGNLDEDFEIWSGKVVGVLKGGGVLENGGVLENGVVDGDGGEFGNDSSFEDSDEESE
PESEIVDLEDIAGKAPSRKNVAVVESNGKLNGKKEMVTPVIRANLTKQGYKIIGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWQWEM
DDPVEIVNSAIDLHTNMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVD
ELHKRRISTFLVTNAQFPDKIKSLRPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDS
LTALKEKHQRTVYRLTLVKGWNTEDIDAYFKLFSIGEPDFIEIKGVTYCGSSATSKLTME
NVPWHADVKAFSETLSLKSQGEYEVACEHAHSCCVLLAKTKKFKIDGQWYTWIDYEKFHD
LVASGSTFDSTDYMAATPSWAVYGAEESGFDPAQLRFKKERHHKSTRVQSS
>A0A0F8GVC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei|TrEMBL
MPLEEKKEEQENFGENLPEVQEENTGEEPTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQSKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYIRVCQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSEELAKHLGYEITDESEISRVVLLSKDGRKSPVKKK
>G4UIA5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neurospora tetrasperma (strain FGSC 2509 / P0656)|TrEMBL
MDSTQRVQTDEDERRPLLDGRGRAEGFKSNAAAAAAAAAGEPAKTTWAGRNQWIVLAMAS
GACAAFNGAFAKLTTTELTSNFSQAVARLLHLSEEEKVIEVVVRGVFFGLNLLFNGVMWT
LFTKALKCGLSTTQVSIMNTSSNFVITAMLGFVIFSEALPPMWWVGAAMLVAGNVIVGRK
DEGEGQGSSDTKQDGDGHSTGNGSGNNDAASVGGSTEGLAEGGLATYRRAVQAEGSGSRG
RQGDGIPAVDDTEKEDSDEDCMNCYFLADLLSRYRFGFILCQWNALRFCYVEWYGPHDEM
KGSLESLVPKLNIRKTRLLMPFEIPGLNPAAVAEVARYAVELWHEHRIPILLSAVFLLGL
LRTYLHLYSEPRQALLVLPKIYEPNEKTKETTLVETEVEDKKTGAAITKKAKSANGGPKR
IKGDKVRTKKGTNGNDTGSESEGPRKIQVLVFYSSLTGNTERYTKDFAKELGDLLVGQSD
AESKAESNFLAPQVLDLAEIDFDEYFLSPMKGPVDYFYCLIIPSYNIDSINDTFLAHLDE
THNDFRIDTSPLAPLIGYSVFGYGDRDGWPTEEEGYCVQAKQVDRWMAKLTGRKRAFPLG
MGDYKRDGKERLSEWQNGIVDVLKMIEQTGSLGEGVPGSGDPFESDEEDIAEDDGEVVYE
ESESKKTLEDVEDLGRIMKQSQGDGPAAPIAIDFTDFGKTGKTVRARKSATVTVKEMVPK
DSPTYTSLTKQGYSIVGSHSGVKYSFYGIASHRCAEATPSLSCSNKCVFCWRHGTNPVGT
SWRWVVDPPDLIFNGIKENHYKKIKMMRGVPGVSSSRFVEAMRIRHCALSLVGEPIFYPY
INEFLGMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKNSLRRIDRPLHRDFW
ERFQRCLDILRERRFRQRTVFRLTLVKDFNIEDEIEGYADLVERALPCFIELKGVTYCGT
STAGAAGLTMANVPFYQEVCDFVVKLNDALNKRGLGYGIAAEHAHSCCVLLASDRFKVDG
KYHTLIDYEKFFDLLEEKGPDGDFGPEDYMGAATPEWATWGNGGFDPRDQRVDRKGRPIE
RP
>A0A851X620|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corvus moneduloides|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAIAFGISLWIVVQFTTTRTKRKVTEPKSHGNPA
SSEGTADKLGNGCALPQPQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINM
GDYDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLR
YAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWK
AKFLTRLQALCKGEKKPCSGKCKKGKCKSSGRQSKESSDHEHGTSEHENTEAEELFETSS
EEEAGGTDSVVDVEDLGNIMGHMKKAKVLLLEGHWAHGVNHCRYQLVCLVDHFLQAKLNC
LMIFALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKH
CALSLVGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTQE
SLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLITLGKPDF
IEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSK
FQVDGEWRTWIDYGRFQELVREHEQSGGSRTFSAAEYTARTPPWALFGARELGFDPLDVR
FQRKNKARDISGC
>A0A314Y702|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus yedoensis var. nudiflora|TrEMBL
MPLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSPSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNDLAFDLVDPNHYEPEDLPKETLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGASEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNGVGAECEAESFDGSDDDDEEEDDVESEV
VDLEDIAEMVTPVIRASLVKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAIDLHSKMIKQMKGVPGV
TLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTFLVTNAQFPEKIKMLKPI
TQLYVSVDAATKESLKAIDRPLFGDFWERFIFFVCPDVPNVFTKGFLEISKEKQQRTVYR
LTLVKGWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPWHADVKAFSEA
LALKSNGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSSGRPFDSKDYM
AATPSWAVYGAEEGGFDPYQSRYKKERHHRSNQ
>A0A0M9F075|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium langsethiae|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAARIYFQFSGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEQVEIEDKTPTIESVEEKKNAKSQGPRRIKGGLARKPSKKPEEE
KDLTRPVVPLVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKAHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWAQGVEE
VIEYVTRTGNLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDRKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTSYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A7K8CUT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eulacestoma nigropectus|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPTSSEG
TADKLGNGCAPPQAQEVRVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRCLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNGTGGEGTASGWARGGTGWILGKFLPGKG
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKG
>A0A852HTW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nicator chloris|TrEMBL
LDISMDTWSYFHTCLVSIWLYRFYIYSAVAFGISLWIVIQFSTTRTKRKVTEPGTADKLG
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALGEAVTSLNLPVEVINMGAYDPEDGLA
EETSSKNICVFLVATYTEGQPPESAGWFCKWLEEAANDFRVGKSFLRGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQAL
CKGEKKPCGGKCKKGKCKSSEKQSKESSDHEHGMSEHENTEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGRMKKAKVLLLEGTWNVHGVHHSGYHLVYFVCQFLQAKLNCLMICALFSG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWEMDQPEVILQEAIEKHQNMIKQFKGVPGVKAARLEEALAVKHCALSLVGEP
IMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFLDSLKALAEK
>A0A1V5AFZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaU1.Bin028|TrEMBL
MEDSSEHTAALVRQGYHMVGHAAVKPCLWLNRSLRGEDQCYKHHFYGISSHRCIQMTPVL
HCNHLCMHCWRPVDQPIALPREWLEPDDLLQRVVMEQRRVLSGYGGSPVLDRERFEESKV
PAHLAISLMGEPTYYPMLDELIDAARRRSMTTFLVSNGTRPEVLERVRPTQLYLSLSASD
REQYLHAAHPSRDDWDQVLSSLHLLGDHASRTVVRITLVKGFNMDPEGFFSLLKEAGPDF
IEAKAYMHLGKSRGRLTREAMPSHEEVMAFSLRLAENLGYSLSGEVPLSRVALLTNNRRP
RIIEEH
>A0A438K153|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vitis vinifera|TrEMBL
MRLFEAYHSHSARLTLLALLSASTLYCFYKSLRLKRHALLFPTTNPNSSSRGKLFFVSQT
GTSEILARRLLRLLTSCDLSFDLVHPKDYEPEDLSKETLVLIVASTWEDGNPPPDAGFFS
NWLAESADDFRVGSMLLSRCKFAVFGVGSRSYGAAFNAVARGFSKRMRKLGGLQVLPVEE
GDVDAGDLDEVFDVWSRKLISVLKGGSVENGVFDGSMAVVESDAETIDGSEEDYDDDDDA
DRENGAEGSIVDLEDIAGKGPSRKTKTMTTSSGTINGEKEMVTPVIRASLEKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WRWKMDDPLEIVNSAIDLHTKMIRQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEI
NSLIEELHRRRISTFLVTNAQFPEKIKELKPVTQLYVSVDAATKDSLKAIDRPLFGDFWE
RFVDSLKALREKQQRTVYRLTLVKGWNTEEIDAYFNLFSIGKPDFVEIKGVTYCGSSATS
KLTMENVPWHADVKAFSEALALKSKGEYEVACEHVHSCCVLLAKTDKFKVNNQWFTWIDY
EKFHDLVASGRPFNSKDYMAATPSWAVYGAEEGGFDPGQSRYRKERHHRPKTTD
>A0A3F3R6L5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus niger|TrEMBL
MEGSGNEGLLAFWHSYRLPLLLALATLLVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISNSTEKDIGTDLKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPAVSFI
QPIIFFASLTANTERYAQVLLEELRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSESDKANGRKRNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPF
YEEVQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDKFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQAAAAATEAQG
>A0A2J7QXM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cryptotermes secundus|TrEMBL
MLGIETRWFSFEVTEAATLCISHCPNMFTVLGIPLIGTLFLPTLLGVITFYIIWSLSTRR
KDSSCTGGLSSAAREPSDPMLAVNDLTSKPETKVFGNRAVSSPNLQSEDNSCTESDVYSV
TQIKVQYASNSRRKVFRSKAGDQCSQTVQVVSDLTKKNTRKKRCKGKPGCCSKKNGASTI
LEGTIETVKVFFGTQTGKSKIFSTVLAEGCEQRGLSSELVDLASADPEERLLEETSGNSL
CVFILPTYTEGKPPESAAWFYKWLQEASNDFRVEKELLKGMKFAVFGLGNSQYKAHFNEV
GKQVDGWLQELHAARLIKLGIGDEDTVASKHGSIEADFQNWNSQLWARVDKLRAACQCDA
TEQDQAESSCDSSSEGCYSDGDSSEQDSRGNGVLDLEELGSFSNSLLAARERKFEDNSPR
EMVTALLKESLTKQGYRIVGTHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDPPEQIMTEALENHYNMIRQFRGVPGVLPERFAE
GMDVKHCALSLVGEPIMYPEIGSFVRLLHERGISTFLVTNAQFPEALRDLSPVTQLYVSV
DASTKSSLRKIDRPLFKDFWERFIDSLKALSEKGQRTVYRLTLVKSWNADEIADYAKLVA
IGKPDFIEVKGVTYCGTSKASNLTMENVPWHGEVLSFVKKLGGLLPDYDIASEHEHSNCV
LLAHQKFKVNGEWWTWINYDKFHELMRQYYLTDGASTFTAEDYMCKTPSWAVFGALERGF
DPAEKRWHRKTLPKKDISGC
>F6TJ39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monodelphis domestica|TrEMBL
MDASLDVWDHFSMPLMSLWVNRFYLYLGLAFGISLCICVQVAIKKLGDRSTKESSLQKAP
LTPAANGPISRQKKEEVFVSGVKIFYGTQTGTAKGLATRLAKAVKALGFPAVVVNLKEYD
PDDRLGEEVTSKHLCVFLVATYTDGQPPESAEWFCRWLEEASNDFRFGKTYLKGMRYAVF
GLGNSLYDGNFNKVGKNIDRWLWMLSARRVMTCGEGDCNVVKSRHGSLEADFAAWQAHFL
SRLQDLSRSDHSKKKAACRHRQGHCKKGECKSKKKEGKNAGPEGSRQEAPEEEEQFETTS
EEESGPEEGRSRSPVVDVEDLGKMMDSMKKAKKEREQQDMEQDMSRSPGKNEAREKREMI
TPALREALSKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPDMILQQAIDNHQNMINQFKGVPGVKAERLEEGLQ
VKHCALSLVGEPIMYPEINGFLKLLHQHRISSFLVTNAQFPTEIRNLEPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVEELRAYAELVSLGE
PDFIEVKGVTYCGESSASNLTMANVPWHEEVIHFVEELVGLLPQYEVACEHEHSNCLLIA
HTKFKIDGDWWTWIDYDRFQELIQEYENSHGLKTFSAKDYVAKTPHWAVFGASERGFDPK
DTRFLRKNKAKDISGC
>A0A1A8MVF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius pienaari|TrEMBL
MLRLLLFLSHITAHVASSDTNAQQEAPRSGESYLLWVWTNRLYVYSAAALVFGTWFLVKV
TQQEKHTDSAGPSCTSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVD
MKNYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGL
RYAVFGLGNSVYVGRYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAW
KVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVDRIESSSEEDESGLA
DERTSGSVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGERREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCAL
SLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
KIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEV
KGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKV
DGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQR
RNRTKDVSGC
>A0A832LI41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp|TrEMBL
MFISKSGKIKRLEKMGYRFVGENAHTAVKTCLWTKKSILDEGTCYKQKFYDIKSHRCLQM
SPSIFSCQQKCLFCWRDLRSTKTAWEGDYDEPASIIDDCINAQRNLLCGFFGNEKANKKK
LLEAQKPNNAAISLAGEPLLYPMINELIKEFHKRKFTTFLVTNGINHKALENLSEEPTQL
YISLDAPSKKIHNKICRPQTKNAWECLNRSLELFPSFNCRKVLRITAVNGKNMTNPSGYA
SLIKKAQPDFVEVKAYMYLGYSRQRLEIENMPLFFEVYEFADEIAKLTNMDIIDESKESR
VVLLG
>A0A2K5F1B2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aotus nancymaae|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAFSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGYVSLHKKDIFVSGVKIFYGSQTGTAKGFATVLAEAVVSLDLPVAIINLKEYDPDD
CLIEEVTGKNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVSRGEGDCDVVKSKHGSIEADFRAWKTTFISQL
QALQKGERKKSRGGHCKKGKCESHQHGSEEREEGSDEQDELHYRDTEEEEPYEGSSEEEF
GGEDQQSVNSIVDVEDLGKIMDHMKKEKREKEQQEEKTSLFRNTGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVIAERFEEGLTVKHC
ALSLVGEPIMYPEINSFLKLLHQRKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKER
LKKIDRPLFKDFWRRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGSEWWTWIDYNRFQELIQEYEDSGGSKTFSAEDYVARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A8C5V2N4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microcebus murinus|TrEMBL
LDPSLEMWDLSSPLISLWINRFYIYMGFAFGISLWICVQIVIKKQGFATILAEAVTSLDL
PVAIIDLKEYDPDDHLVEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSAYASYFNKVGKNIDKWLWMLGAHRVMTRGEGDCDVVRSKHGSIE
ADFRAWKTKFIYRLQALCKGEKKKSCGGNCKKGKCESNQHGSEETEPGSHTPDDLHPRDT
EEEEPGENTSEEEFGTEDHQGLNSVVDVEDLGKIMDRVKKEKKEKEQQEEKTSLFRSTGK
NEDGERRAMITPALREALTKQGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILKEAMENHQNMIKQFKGVPGVQAERFEEGMTVKHCALSLVGEP
IMYPEINRFLKLLHHCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLKKIDRPL
FKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYC
GESSASSLTMANVPWHEEVVRFVRELVELIPDYEISCEHEHSNCLLIAHKKFKIDGEWWT
WIDYNRFQELIQEYEDSGGSKTFSAKDYVAKTPHWALFGANERGFDPKDTRYQRKNRAKD
ISGC
>A0A3M7F964|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFALLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKSAASQEAQVIEKVQPI
IFYYTLGGSTKVYAESVAQDLATSSPSSVLEPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKDESDNMLREWTEGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETAAQRKPKRKSANRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINDLLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKGLAKRG
LDYGIGAEHAHSCCILLADRGRFFRVPAAEKDNPAAERKWHTLIDYPRFFDCLESGKPFA
PEDYVGPPTPEWALWGNGGFDPRDERVDRKGRPKEPRVQEVQEVQEVQE
>A0A139CQ87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus sp. T82-4|TrEMBL
MSRRRQKVREITDFKSLLKKQGYSLAGKHSAVKTCLWLGRAIKGEGECYKSHFYGIQSHR
CLQMTPTLMCNQKCLHCWRPTEIDVPMPEGWDSPVEIVGSCVDSQRKLISGFGGSAPREL
WMEGNEPGHVAISLSGEPTLFPHLPELIEEFKSKGLTTFVVSNGTVPAMMEKINPSQLYM
SLDAPDRETYEKVCVPNSPGLWDRINESLDVLRKKDTRTVIRITLIKGVNMFNPDAYAYL
IRRADPDYIEVKAYMHLGFSRKRLPREAMPSHEEVLEFSGELAEHLGYLIADDVEISRVV
LLSKDGSVSHLI
>A0A8C3W6S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Catagonus wagneri|TrEMBL
MDPLDMWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKKSQEKTVPNASQNL
MTNGYLSLEKREIFVSGVKIFYGSQTGTAKGFAAVLAEAVAALGLPVAVINLKEYDPDDH
LAEEATSKNVCAFLLATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYAHHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRKGEKKPCSGNCRKGKCESHQRGSERAEPGSQAQEGFRQRDAEEEELLGSTSEEESGP
EDLQSLSSVIDVEDLGQIMDRVKKEKREKEWREGETGVFGSAVENEASEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWCTWIDYNRFQELIQEYEDSGGSKTFSAKDYTARTPSWALFGASERGFDPRDTRYQR
KNKAKDISGC
>A0A834VBF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sarcoptes scabiei|TrEMBL
MHKDSRVFFSSDQKQTSNSDRNDSEKRRKKFKNSIFNLSTNIEINPILKMFNNLLGFCRK
IFRQNKTIPLLVLASAICWKLIQRFKLREFFLDKLRSQYRLKDKFRRNSKLKIIYASNSG
VTKSLALKLYDAIKEKISTEETMDQFQSIELLHADQYDPEDELINDARLKTLLIILMPTY
SQGEPPEEAEWFCKYISESSEDFRFPKNALIKLRFIILGVGDSNYGDDFCKCAFNLERCL
KNLQANCLIPMTGIDVSSNESIEDQFSRWFDNLSLIFQQSDRTVPPSRNSRSSISPEYSC
SEKTDSSDFEELCSPPDQIVDLEDLVEPIKVRSKDGESKSSTLINDMITPKIRKELSKQG
YKLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHS
NPVGTKWQWNLDDPEMIFNDLQKQHYSMINEFKGVPGVLPERIDSARTIRHCALSLVGEP
IMYPKINELIRLLHSRSISTFLVTNAQFPDAIKNLEPVTQLYVSVDASSKISLKKIDRPL
FHDFWERFLDSLRYLSLKNQRTVYRLTLVKSWNSDEIDGYAELVMIGRPEFIEIKGVTFC
GDSSDSKLTIKNSPRHCEVVGFSQSLTIKINHLIRQNIIKHKGNEGFNSPDIENEFYAIA
SEHEHSNCVLLAKKKFYISGFWYTWIDYDRFDSLIKEYYESKGKKTFSSKDYCAQTPRWA
NFGAKEQGFDPEQTKVKKERRHYNQTM
>C1E003|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709)|TrEMBL
MSSVLPKLRALRDSLRTKLGLHGGPSTATVAVEPTRKPPDACGGAESCCRADDDAGAESC
CRADDNRDDAGCVAPTVTGGRILFGSQTGTARRLAHKLANSLRTRHRVDLQVTDLADYDP
EDLVKEKVALVVLSTYESADGAAPPDAARWFCKWASESSRDERFGMLYLMRVKFAVFGCG
NREYGAERFNAAARSLDADLARLGGERVLRRCDGDESSGKMEEQFHDWVDKLAERLNPEG
AFAAKTNLAPAVDADVDKKETFYDTDDEEGSGDDDYEGASAGSEDGMDMEDMGGDATGEK
REMVTPQLRAALTKQGYKILGSHSGVKLCRWTKAQLRGRGGCYKHSFYGIESHRCMEATP
SLACANKCVFCWRHHTNPVGREWRWQMDDAETIVEKAVSEHRGMIKQMKGVPGVIPERFE
EGMDPRHCALSLVGEPIMYPEIDKFVGLLHAKRISTFLVTNAQFPDAIKNLPAITQLYVS
VDAATPETLKAIDRPLFGDYWDRFVSSLTALRDKNQRTVYRLTLVKGMNAEDAAEYAKLI
DLGKPDFIEIKGMTYCGTTSGASNLTMENVPYHEEVKKFGEDLCMARLKQQGGDTGGELT
GGTPKEAEYGLACEHAHSCCILLGRKDPYLVDGAWHTWIDYEKFQDLAASGEQFRSEDYM
LPTPHWSVWGAEEGGFDPGETRVRKVRNHPGKDSAQSSPRPTGD
>A0A010Q2B4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum fioriniae PJ7|TrEMBL
MASTLEPVGFKSMLNTFGLLILRFYLHSTEEKSELKALPKAFNREKPETKPVEEKKDVKP
SPPSPAVESKAPKSNGPKRIKGGIVKRTSSNEAKGEALVRKVRPLVFFSSITANTPKIAK
EYAEGLEKELQKVAAETDCTFATPEVLDLAEVDFDDYFITPPKSEEDPADLFYLFLLPSY
NIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDREGWPTEEDGFCFQAKQVDK
WMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVVDVLGMLAKTGSLGEGLPGSGAPEES
DDESAAEDDDEVLIEDSEAKPEKLKSRKNIDDVEDLGRIMKSSNPDAATNGRAAKSATAG
AAAPIAVDFTTYGKTVAKKTPLNAAKEMVPKNSPTYASLTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELI
FDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFLGMLHAER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLDILRE
KRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYCGTSTASNAGLSMSN
VPFYWEVQEFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKDGKWHPRIDYQRFF
ELLEERGADGDWKPEDYMGEATPEWATWGKGGFDPRDDRVDRKGRKIEV
>A0A3B4T7E6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Seriola dumerili|TrEMBL
MLNFFLVILLFLRHVSTSDTKVSQNEHRPSESYFMSIWHNRLYLYSAAALVFGIWFSLKM
ALKKKSFSKDIGPWVYKAVKNNDSSDRDTAVHVSGVKIFYGSQTGTAKAFAKELSEEVKN
LGIPAEVTDMKDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRVMTRGEGDCNVVKSRNG
SIQADFQAWKVKFLNRLQALAKGEKKSCSGNCKTGGSCKNKRKDGHMEEEEEEEKAAPQN
PSPEDALIESSSDEDESGLQDEKKSGSVVDMEDLGNIMNSAKKAKSKEEGRGDGQTVKLS
KLNGVKKIGDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILRDAVEKHQNMIR
QFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSQQISSFLVTNAQFPQ
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVK
AWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADML
PQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQSFSALDYMA
KTPSWALFGACEQGFDPADTRFQRRNKTKDISGC
>A0A7R9U1E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pinguiococcus pyrenoidosus|TrEMBL
ARSAPRASLIRRLPQSFDTYITMLWWLFGGLLALSLTLLLFFRSGSAPKPPPKADERTRL
LVLYGSTTGTSRLLAAQLSQEATALSALGMPISVEVKNVSDVDPEDLGSSSAELFVLLLS
TWTGGQPPVSAEVFCKSLEEMSKDFRVGSAFLKGKKAAVFGLGSCHYEENFCLAAAKAAQ
HLQDLGAELLFPVQKGDDSVGVELGFRGFCERLWTALRKDASATARTAEPALTAPQGRLP
LKEYRRKKRRERAEKKLREAREQQEQRLAQATAEDNYNAHLCEEDESEDEAKPKTASLLD
MEDLGQSMAPKATEMKDDARAEMVTPLQRQSLVKEGYNIIGSHSAVKVCRWTKNQMRGRG
GCYKHTFYGITSYQCMEMTPSLACANKCVFCWRHHKNPVGREWRWQVDDPHEIVASAVER
HRGMIKQLKGVPGVIPERYEDAFNVRHCALSLVGEPIMYPHINELVDDLHSRRISTFLVT
NAQFPEQMANLGPVTQLYVSIDAATPESLKEVDRPLFKDFWQRFVDSLSALRSKKIRTVY
RLTLVKSYNMQEVLDYCSLLEIGRPDLIEIKAVTYCGKSDASNLTMEHVPWHQEVVSFAS
DIASESSLDYELVCEHEHSCCVLLARKKFNVDGRWHTWIDYPRYFELFERFQRTGEEFGS
EDYMAETPAWALVGSEERGFSPNENRWRRNRRTQTPKSE
>A0A438NEN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala mesophila|TrEMBL
MDLGDGGAMPVILADWLDRGLTVWHESRVILTAVLVACFLTILVRRRQSTRPFTQSSSPA
LEKADGRQGSQIEKLSISETYDVDSKTTLAAAPTQKIKTRPAAARIVTGRKPASTARNGN
LKQVQEEVTHIQPLIFFSSLTGTTERLSKIASESLQALSTRNTSILQPEVRDLSYVDLDD
YFISGPKTPSPRAGTVFFYLLLIPSYDIDTILNTFTAHLDETHNDFRIDTSPLAVLAGYA
VFGIGDKSGWPNEEQGFCSQAIEVDKWMAKLTGRKRAYPLGLGDVKDNATHALREWTDGV
STVLEELISTGSLGEGVPGSGDAIESESEEEPEMVDEEEDFPDSGRNKRRKIANTTDLED
VGGKTKTKHSSLAVDFTTYSATQVTQPVLKAMVPKESPTYASLTKQGYTIVGTHSGVKIC
RWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDD
PNLIFEGAKEGHYKKIKMMRGVPGVRSDRFEEAMRIRHCALSLVGEPIFYPHINKFLDLL
HGERISSFLVCNAQHPQQLRDVKRVTQLYVSIDASNKESLRKIDRPLHRDFWERFQACLD
ILREKRFVQRTVFRLTLVKGFNIEDEVEGYVNLVAKGLPCFIEVKGVTYCGTSTSANAGL
TMQNVPFYEEVAAFVEALNVALAKRGLEYGIAAEHSHSCCILLASNRFYINGKWHTVIDY
DKFFQLLESGQDFRPEDYCKETVEWALWGNGGFDPRDEKVDRKGRPKEATKLTGKKIDSS
KLDF
>A0A832ZAQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrodictium sp|TrEMBL
MRTVRGKFWKLRIDDFPEPYRSLYTLLKKQGYVLVGRHTVVKKCHWTHMALTQKRFCYKC
KFYGIASHRCVQMSPSALWCWNACLHCWRARPQDIGISWDETKLLWVDDPEYIAKGSIEA
QREILSGYKGHPKVDPRMYEEALNPKHVAISLTGEPVLYPRLSELIEIYHKMGMTTFLVT
RGVRPDVLANLDEEPTQLYVSIEAWDKKSYEYFNKPLVPRAWELTLETLELLPSFSCPTV
VRITLVKSFNMHEEALKGFAKLMEIAQPTYIEVKAYMYLGYSRNRLKPSDMPKHEEVLDF
AKKLGELIGYNILSQQIASRVVLLSKLDKPIRVGEGCPGAWKKWREEWESEEAEYKLAKE
S
>A0A0D2CVD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cladophialophora immunda|TrEMBL
MDLGEAGAAPVILADWLDRLLIYWHENRVVLSTILGLCVLAVILRRRHAHHIAQRGSPTL
EKAEWLTQNDNAHAQVARDEKIQTSSRSSPSLISGQARKPRTAAAATRVVTGRKPASSRG
GQAALQRRREPSRIQPLIFFSSLTGTTERLSKQVAANLEEVSTSQPSILRPQVYDISYVD
LDDYFISGPKTPAPNADVLYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLA
GYTIFGIGDKEGWPTEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKNGLDKSLKDWV
GGVCTVLREVSKTGALGEGIPGSGEPVESGDEDEPEEMDDEVEFPDSGRNKRRKLANTTD
LEDVGGKTNSYASPIAIDFTTYSSRPPAPPTLKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPHLIFEGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNS
CLDILREKRFVQRTVFRLTLVKGFNVEDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALDKALAKRGLEYGIAAEHAHSCCVLVASKRFLVDDKWHTL
IDYDKFFDLLESRRDFAPEDYCRETPQWALWGNGGFDPRDERVDRKGRPKEKKTGDDVGE
DKRGSRPGEDKVELDF
>A0A168KA03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Akanthomyces lecanii RCEF 1005|TrEMBL
MDPLGGAHGQSALFNINVAFCGLLLLRLYLHVYEEKPDLKTIPKLYGKVATQKPDNVSQR
DMQAKAAVKTAGPRRIKGGMAKKPETSEEPIDLTKPVKILVFFSSITTKTEKIGQDYIAK
LEKSVAQLAADTQRQVLAPELLDLTEIDFDDYFIAPPKSDDGAQFLYLFLIPSYNIDSIN
DTFLEHLQETHHDFRIDTAPLSTLLGYSVFGFGDREGWPDEAEGYCFQAKELDKWMAKLT
ARKRAYPVGMGDMKSDHAERFAEWTGGVEEVFGQIIRTGYLGQGVAGSGAAVESDDEVEE
EDYDDGEVVFDDEKLAKRENGKKSSSLDDVEDLGRVIKSQGGDANPKAPIAVDFTTYNNS
KASSQSKPKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKYSLYGI
NSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFDGVKEGHYKKIKMMRG
VPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKERISSFLVCNAQHPDQLAD
LKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILREKRFRHRTVFRLTLVKGF
NVEDEVEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFVRALDTR
LQEKGLAYGIAAEHAHSCCVLLASERFHVDGKWHTHIDYDRFFELLEERGPDGDWTPEDY
MGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVIREAPE
>N6V010|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus villosus KIN24-T80|TrEMBL
MKMIELLRKQRYQIDNHTAVKLCGWVRKKMLEDKNCYKSKFYGIETHRCIQCSPAFMWCQ
QSCIFCWRVLPSDIDAKIEEPNWEEPEVVYEKILKLHRRAIMGYKGILNRVGEKKFNEAL
NPKHVAISLSGEPTLYPYLDELIKIFHKNGFTTFVVSNGILTDVIEKIEPTQLYISLDAY
DLESYKKICRGKEEYWENILETLDILKKKKRTCIRTTLVRGYNDDILKFVELYERADVHF
IELKSYMHVGYSQRRLEKKHMLKHDEILKLAKMLEEESKYKLIDDAEDSRVALLKNTDRD
ISVKIC
>A0A1F9YK34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon RBG_13_31_8|TrEMBL
MKPEFKKILEKQHYAIVGDHSAVKLCHWMKQSLLFNRECYKQTFYGIKSYRCLQMTPSIN
QCNQMCLFCWRHQGFTEKDFEKIDDPAFILDESIKIQKKLITGFKGNIRCNLKKWEEANN
PNMLACSLSGEPTLYPYLSDFFKECHKKNIITFLVTNGTNPKALKNLDTLPKQLYVSVVA
PNKEIYKKICSPLIPDGWDRLNQTLELLPSLDTRIVIRHTLVNGWNMSEKNISEYAKIIS
KANPMFVEPKGYVFVGYSRKRMTIKNMPVFDQIKVFGNKLAKDMGYYFLMEKPDSLVVLL
SNKLKPARFDK
>A0A7J3A7W4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaerales archaeon|TrEMBL
MVKQPQKAASVERIPEELKQILKKQGYHLVGEHSATKKCLWLHNSLVYKRPCYKEKFYGI
SSHRCLQASPAVLSCLTRCIHCWRIMPGDEGYNCSDTFSNIWDEPKFIAEGLIKEHKRIV
CGYGALVKEGRVEKNRFRESMEPTNVALSLSGEPTLYPYLSDLIKEFKKRGMTVFLVTSG
VLPKALTRLVELDAEPTQLYISLTAWDEESYQRLNRPIEPKLWSTLQKSLELTPTFTCPT
VFRITLIHGLNDHTEALRGFSTVVSRHQPTYVEVKAYMHIGYSTKRLEKSAMPRFSQVCS
AAEEISRQTGYQIAGRDEDSRVVLLKR
>A0A7K6VK27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Notiomystis cincta|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTATIRTKRKKSPGNPASSK
GTPDKLGNGCAPPQAQEVPIAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDY
DPEDSLSEETSSSNICVFLVSTYTEGQPPESAAWFCKWLEEAANDFRVGKSLLQGLRYAV
FGLGNSAYVDHYNTVGRSIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKANF
LTRLQVLCRGEKKSCSRKCKKGKCKSSEKQSKESSDHEHGMSEHENAEGEELFETSSEEE
AGGTDSVVDVEDLGNIMGHMKKAKVLLHSRYHLVSFVCQFLQAKLIGLMIFALFSGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEMILQEAIEKHQNMIKQFKGVSGVKEARLEEALTVKHCALSLVGEPIMYP
HINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDF
WQRFLDSLKALAEK
>A0A2H2ZFW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma parareesei|TrEMBL
MDAASRLQLEALVADLVDVWHAYRTPIILSALLLLAGLRIFLHTTEDREPLVALPKIYNE
PQQPQVSQKTISKAQPVAETEKKPFGPRRIKGGVTRKASQEDKTAPAKHDRPAKVLVFFS
SVTTKTEKIAHDYIKTLETFLDQKANETDAKFLKPELLDLTEIDFEDYFVSPPKSPEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLVGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFTEWTSGVQEVIAQASQTGFLGEG
VPGSGDAVESDDEEAEGDDGEVVFDDEEPSNSKESDGSRPLDDVEDLGKMIRPSKDGNEG
PRKAPLAVDFTTYPSASKRKGQAPVIKEMVAKDSPTYNALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEM
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALDRRLQEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQRF
FELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAVVSREAPE
>A0A2Y9R6J0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichechus manatus latirostris|TrEMBL
MDPSLDTWNFSSPLISLWINRFYIYLGFAFGISLWICVQIVLKKQREVFVSGVKIFYGSQ
TGTAKGFAEVLAESVTSLDLPATIINLKDYDPDDHLVEEVTSENVCAFLVATYTDGQPAE
SAKWFCKWLEEAANDFRFGRTYLKGMRYAVFGLGNSAYTSQFNKVGKNVDKWLWLLGARR
VLTRGEGDCDTVKSKHGSIEADFSAWKTRLTSRLQELHQGEKKPCGSNCKKGKCESGQHG
PEGREPGPHTLEESPHRDAEEEEPFESSSEEECGTEDQQSLNSVVDVEDLGNIMDRVKKE
KKEKEQQEEKSSLFRNTGKNEDNERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILK
EAIENHQNMIKQFKGVPGVRAERFEEGMKVKHCALSLVGEPIMYPEINRFLELLHQCKIS
SFLVTNAQFPEEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKQ
QRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASNLTMANVPWHEEV
VRFVHELVDLIPDYDVACEHEHSNCLLIAHKKFKIDREWWTWIDYNRFQELIQEYENSSG
SKTFCAKDYMAKTPQWALFGAHERGFDPKDTRYQRKNRSKDISGR
>A0A2Y9DV10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichechus manatus latirostris|TrEMBL
MDPSLDTWNFSSPLISLWINRFYIYLGFAFGISLWICVQIVLKKQDKNSQEKSVPKVTWD
LMTNGSVSHQKREVFVSGVKIFYGSQTGTAKGFAEVLAESVTSLDLPATIINLKDYDPDD
HLVEEVTSENVCAFLVATYTDGQPAESAKWFCKWLEEAANDFRFGRTYLKGMRYAVFGLG
NSAYTSQFNKVGKNVDKWLWLLGARRVLTRGEGDCDTVKSKHGSIEADFSAWKTRLTSRL
QELHQGEKKPCGSNCKKGKCESGQHGPEGREPGPHTLEESPHRDAEEEEPFESSSEEECG
TEDQQSLNSVVDVEDLGNIMDRVKKEKKEKEQQEEKSSLFRNTGKNEDNERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVRAERFEEGMKVKHCA
LSLVGEPIMYPEINRFLELLHQCKISSFLVTNAQFPEEIRNLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASNLTMANVPWHEEVVRFVHELVDLIPDYDVACEHEHSNCLLIAHKKFK
IDREWWTWIDYNRFQELIQEYENSSGSKTFCAKDYMAKTPQWALFGAHERGFDPKDTRYQ
RKNRSKDISGR
>A0A7K8HPU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aleadryas rufinucha|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPKSHGNPT
SSEGTAGKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINM
GDYDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLR
YAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWK
AKFLTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSS
EEEAGGTDSVIDVEDLGNIMGHMKQAKWGRAALSPWCYHSGYQLICFVCQFLQAELNCLM
NFALFSGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALRVKHCA
LSLVGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALAEK
>A0A1Y2D194|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizoclosmatium globosum|TrEMBL
MAAITILFSTQEGTTETFAEKLANEITAKLILPKDVAFPPVEVKCIKNFDIDALLKRTSN
ELVFFFLTTYVDGGPADDAAWFGSWLEDMRYDFRVSKESMANIRYSVFGVGDSAYGENHC
LFPKKVDKYIHEMAGVRVCESVFGDVGTPQDFDGVLDNWIDSCIRGIVGALSGSEAVLST
GISNITLVGEKEDEYEELDEEYVTSDEENDDVYVDAKESNELMDLEDLGSYAAAGLKAAK
QARDEDQANGVVINRKKGTSTTTTHTREMLTPNLRKNLEKQGYKLIGTHSGVKLCRWTKA
QMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRLQTNPVGVEWRWKADRPEEIV
EGAIEKHRLMVKQMKGVPGVTAEKFQEGMDVAHCALSLVGEPIMYPYINEFVELLHQKHI
SSFLVTNAQFPELIRKLQPVTQLYLSIDAANKESLKKVDRPLFSDFWERFNGCLDELAKK
EQRTVFRLTLVKGFNVDELKEYAVHVRRAKPDFIEVKGVTFCGYSGSNPLTMQNVPFHEE
VVEFVKLLCAEIDDDYEISCEHAHTNSLLISHKKFKINGVWHTWIDYPKFHELVNSGAHF
TSMDYLAPTPAWAVFGDDRKGFDPEMTRVYKNKAKYEGDGAAYRDKIKESMIGSGNLAAA
AELD
>A0A075FXF5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine group II/III euryarchaeote AD1000_79_C02|TrEMBL
MQSPITRIEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCM
QMAPNVDTCNLACTYCWREPHSETLHKIDDDPYELFLESVRAHRRLITGFGGNPKADPEK
FREAQDPKHVAISLNGEPTLYSRLGEFIDVCHQHGVSTFLVTNGSLPKVIENLDPLPTQL
YVSVDAPNKEIFDRLCKPKFDQAAFHKLEATLELLPSLDTRTVCRHTLIKGESLGHHEDY
ARLDNIADPDFIEAKGYVYVGNSRNNLSIENMPSHDDVMGFSHRLAPLVGREVLSDRRES
RVALIAREMIPVTLPEKVRELPRDLGIAKPQRFVLPQA
>A0A842XYX9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedenaceae archaeon|TrEMBL
MTGISESTMELLARHGYHIAGSHGAVKTCLWLNRSMRGEGGCYKSHFYGMASHRCIQMTP
TLVCNHRCLHCWRAVEAPVPLPGKWDSPEELVEGCMKGQSRLVSGYGGSKTTESARWKEA
YEPKHVAISLSGEPTTYPYLPELIEEFHSKGMTTFVVTNGTNPGMVGKITPTQLYISLNA
PDADTYAKACAPLSDTWENIKQSLEIMKSSRTRTAVRITLTKGVNMFNPEGYARLIETAE
PDYIELKAYMHLGFSRKRLSRENMPMHNEVLDFSRQVAQEMGYKVADESQISRVVLLSKD
GLKQGISNDM
>A0A672LSU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus grahami|TrEMBL
FQTSYLNLSKLYSRAFTGALNDVWEFTESYLLTVWQNRLYVYTTAAVLIGVWLTVNMLFK
KKKMVDPISPLLYKSVKNQELSPETEKVLYVSGVKVLYGSQTGTAKGFAKELAGGISAQG
IQCEVIDMKEYDPEDRLAEECTSKMVCVFLVATYTDGQPTESTEWFCKWLEEASTDFRYG
KTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSV
QADFHAWKTKFLNRLQALAKGEKKACSGKCKSGSCKNKKKHKEEEELMESSSDAESSAEE
EKSRGSVIDMEDLGNVMNRMKKAKGDEEDSQRVKLSKQNGVRKSESEEERREMITPALRD
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIR
SLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWN
VDELKAYADLISLGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDY
EIACEHEHSNCLLLAHHKFKVDGKWWTWIDYERFQELIQEYEESGGTKSFSAMDYMSKTP
SWAIFGAGERGFDPLDTRFQRKNKTKDISGC
>A0A556UZY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bagarius yarrelli|TrEMBL
MAGFLENPWLYTEAFLLAVWQNRLYVYTAAALFIGLWFTVTMRKKKPINAGKVSKSEKQN
EEPLEKEKIVNVAGIRIFYGSQTGTAKGFARELAEEVQAIGFQSDVIDLQDYDPEDKLSE
ECTSKMICVFLMATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVY
VGHYNTVGKNVDKWLWMLSAVRIMSRREGDCDVELFESSSDAESEGEAENAHGSVIDLED
LGNVMNHMKKAKKHTADSSEHGKLNGLKKTEAEEERREMITPALSEALTKQGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKMDPAEKILQEALENHRNMIRQFRGVPGVRPERFEEGLAVKHCALSLVGEPIMYPEINS
FLRLLHRCHISSFLVTNAQFPAEIRSLVPVTQLYVSVDASTKDSLKRIDRPLFKDFWQRF
VDSLKALGEKQQRTVYRLTLVKAWNVDELKAYAELVALGQPDFIEVKGVTYCGESSASNL
TMANVPWHEEVVHFEPFICGCSSSSPTDLPKKLPECPMTSSPFKVDDEWWTWIDYERFHE
LIQQYDESNGAKTFTALDYMAKTPSWAVFGARERGFDPSDTRFLRKNKTKDISGC
>A0A6M2E974|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Populus davidiana|TrEMBL
MSLTSTPARFTLLALLSATTIYCFYKSRRLKKISLNPNPNPNKPKLFFISQTGTSKTLAH
RLHNLLASNNLHFDLIDPQNYEPEDLFKEKLVIIIASTWEDGKPPQNAKFFANWLAESAD
DFRVGSLMLSECKFAVFGVGSRAYGETFNAVAKDLSRRLRDLGAKEVVGVGEGDVDGGEL
DGVFEEWSGRLARVLKGESVENGEVCGNGVVVIDESDDDEDDGGVESDIVDLEDIAGKGP
SRRSLVVAQSNGKLNGENGKLNGQKEMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNS
AIDLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHRRQIST
FLVTNAQFPDKIQMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLKEKQQ
RTVYRLTLVKGWNTEDLDAYFNLFSAGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVK
AFSEALALKSKGEYEVACEHVHSCCVLLAKTEKFKVDGQWFTWIDYDKFHDLVASGKPFD
SKDYMAATPSWAVYGAEEGGFDPDQSRYRKERHHKTNH
>A0A7J4FWX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MPKDIKKRLINQHYHIVGKHSAVKVCHWTKKSILDEGFCYKQNFYGIQSHRCLQMSPSVI
WCTHRCIYCWRYIDNKIGYELREIDTPEYIVKNSINAQAILLSGYGGIPDRINWKKYDES
KEPNQAAISLSGEPMVYPRISELIGEFHKRGFTTFLVTNGTLPERIECLEELPTQLYLSL
NAPDDKIYKGVCRPLINNGWDRINKTIDLFPSIDTRRVIRITMIRNWNMFNPEGYGRLVE
RAEPDFVEVKAYMFVGESRKRLNLEDMPSFGDIEEFSQKLSDEIGYRIKDSKEDSRVVLL
SKN
>A0A3Q2UUY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haplochromis burtoni|TrEMBL
MCFLPPVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKKVSKEKNDKVDKAAKK
NDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKSLGLPAEVIDMKDYDPDDQLADEC
ISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVE
ELHWLIIWLWMLSGRRIMTRGEGDCNVVKSLNGSIQADFLTWKVKFLNRLKTLAKGEKKS
CSGKCKTEGSCKNKRKERQEEEKKASPQNNSSEVRAGKLFLLKSSSKYSIIHIFGIQIFA
FKYESQRDGQMVKLSKLNGVQKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAE
KILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHH
HQISSFLVTNAQFPQEIRYNLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPLCRKLFVL
YLHCFSSGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIA
HTKFKMDGEWWTWIDYERFQELIQAYDERGGQHTFSALDYVAKTPSWALFGAQEQGFDPA
ETRFQRRNKSKDISGC
>A0A3B5R5S3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xiphophorus maculatus|TrEMBL
MLALLTVISFLAGSLSTSDTKVPQDVRSPTENYLLWTWNNRLYVYSAAALLLGFCFLLQV
TRRKINHTKDSGLKVQKAAKNKISSDKDGDVHVSGVKIFYGSQTGTAKGFASELSQEVQT
LGIPAEVIDMKDYDPDDRLADECVSKSVCVFLVATYSDGRPTENAEWFCKWLEEASTDFR
YGNSFLKGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSARRVLSRGEGDGNVVKSRHG
SVQADFRAWEVRFLSRLKALARGEKKSCSGNCKNGASCKNRKKHGAQEEEENGSEVELIE
SSSEEEESGLSGEKMSRSVVDVEDLGNIMNNVKRAKGVKEDQGDGQMVKLTKQNGVMKTA
DEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPGVK
PERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHHISSFLVTNAQFPEEIRNLVPVT
QLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVEELQA
YAELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPRYDIACEH
EHSNCLLIAHDKFKVNGEWWTWIDYDRFQDLVQAHEDSGGQQSFSALDYTAKTPSWALFG
SNEQGFDPADTRFQRRNKTKDISGC
>A0A7Z8P2F9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus vulcani|TrEMBL
MSRRRKNKNKDSSDDESGITDFKSLLKKQGYSLAGRHSAVKTCMWLRRSIKDEGECYKSV
FYGITSHRCLQMTPTLMCNQKCLHCWRPTEVDVPMPVGWDSPVEIVGSSIESQRKLISGF
GGSAPLERWKEGNDPKHVAISLSGEPTLFPYLDELVDEFKAQDFTTFVVSNGTVPEMMAK
INPAQLYMSLDAPDRETYEKVCQPKSPALWDNILKSLEILREKETRTVIRITLVKGVNMF
DPQGYAKLIKIAEPDYIEVKAYMHLGFSRKRLPREAMPSHDEVMQFSEKLAQHLGYKVAD
DVEVSRVVLLSKDGSVTHLL
>A0A7J2WT73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MLALSVSTPPHVRKLMEKQGYKFVLNHSAVKPCYWFRKSIMKGKTCYKNKFFGIPTWRCI
QMTPTASFCNMQCVYCWRLNASDVPMSQRWVEVPEGKWDDPEEIAEESVRVHRMLVQGYK
GVRVFNEDWVREAEEPKHAAISLTGEPTLYPSIGGLVGAFSKRGMTTFIVTNGTIPERIE
GLEKEPTQLYVTVPAPNEKLYSEITRPLWPDAWNRLMRTLELLQSLSCPTVMRIPLMKGF
NMDERTLEEFSVLIKKYQPTYVEPKAYEWVGYSRRRLNKWNMPWHHEVREFAEKLSDLTG
YKILDESEESGIVLLSRLERAIRFY
>G9P1M0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypocrea atroviridis (strain ATCC 20476 / IMI 206040)|TrEMBL
MDAGNRLQLGTSVSDLVEVWHAHRTSIILCALVLLIGLRTLLHKAEEREPLAVLPKIYNQ
EKSETNEKTAHEAQPVAVAEKKSAGPRRIKGGVTRKPSQEKKATAVDYTDRPTKVLVFFS
SITTKTEKIAHEYIKTLETFVDQRAGETQGKFLKPELLDLTEIDFEDYFVSPPKSTENAA
YVYLFILPSYNIDSINDTFLQHLQETHHDFRIDTAPLSPLIGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHTERFTEWTTGVQDVIFQAVQTGFLGEG
VPGSGDAVESDEEDAEADDGEVVFDDEESGDGKSSDDSRPLDDVEDLGKMIRPNKDGNGT
IRKAPLAVDFTTYPSAGKKKAQAPIIKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDM
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHNE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEAEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALDKRLQEKGLDYGIAAEHAHSCCVLLASKRFNVNGKWHTHIDYQRF
FELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVTREAPE
>A0A523VPB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVGRHSAVKRCRWLYNTLIHNRPCYKQKFYGINTHQCIQMTPTAFSCTMRCLFCWRVQSG
DGNLTWDETTLPFCDDAEDIVEGCLEEQKKLLSGYKPNPKVNREKYWEANHPKHAAISLT
GEPTLYPQLGELIKSFHRRSFTTFLVTNGTKPEVLSVLEQEPSQLYVSTCAPDKRTFNKV
CRPQISNAWERLNETLALLPSFRCPTVMRITLTRHLNLKHPELYARLIERAQPTYIEPKA
YMHVGFSRLRLTYKNTPHHKEIKEFAASLAEKTGYKILDESKESRVVLLSKLEKPIKLR
>A0A497EUB4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MDNDMLNDEIYSALRRQGYHIVGRHSAVKTCHWLKKSLTKGEYCYKQQFYGIQSHRCLQM
TPSVVYCTNKCIYCWRLVPEAIGVSWNEIELLDVDDPEVIIDGAIAEQRRLLTGFYGNPQ
VDRKKLEEAMNPKHAAISLSGEPTLYPKIGELIEAFHARGMTTFLVTNGTRPDVLSKITE
PTQLYISVSAPNEDKYRNICRPLIRDNWVKLNKSLELMKSFSCPTVIRLTLVKGLNMEGG
DLQGYSELILKAEPTYVELKAYMHLGYSTARLKFENMPSHQEVRDFAERLASMIGYNLLD
ENSKSRVVLLSRLTKPIKVSRE
>A0A7J2JZT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPGVPLELVRLLRKQGYHLVGRHSAVKRCHWLYASLTSGRFCYKQKFYGIATHRCIQMTP
ALYYCTQRCLFCWRAQTGDLGLRWEETRMPEWDEPELIVEGSIRAQRQILSGYKANPKTD
PRKLEEALRPRHAAISLAGEPTLYPELGALIAEYHRRGFTTFLVTNGTVPETLAGLEEEP
TQLYVSLCAPDERTYKALCRPQLPGLWQKLVETLELLPSLSCRKVIRITLVKGWNMKDEQ
AYARLIERAEPDFVEPKAFMWIGFSRYRGLGFENMPRHEEVKAFATRLSAELGYHVLDES
LPSRVVLLGRYDRKWPIGTPRPG
>A0A550GX93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLYKQKYHLVGNHSAIKRCRWLYNSIIQNRVCYKQKFYGIQSHRCLQMTPSVFYCNLGCI
FCWRAQNGDHNIRWDETKLPTWEDPETIIDGSIKEQKRILTGYKATPNVDHIKRIEADTP
RHAAISLAGEPTIYPHLDGLIKEFHRRDFTTFLVTNGTNPKALSKLIEEPTQLYVSVSAF
EKDAFSKICRPQSNNSWKKLNETLGLLPSFKCPTVIRFTLARHLNLEYPKRFAKLVKKAN
PTYLEPKAYMFVGFSRLRLEFSNMPTHKEIKNFGAQLSSELQYKILDESPDSRVVLLSRL
EKAIKLA
>A0A7J3SB43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKITEMILMEAVEKLKREYIKQGYKFIGDYSLLKPCYWLKASLTSRGKNVCYKQKFYGIP
SHRCLQLSPTITCTHECLYCWRVQASDMGIEWNELNLPKWDDPEKIVLNGLKMQREVLSG
FKGNKNVDGSMLEEAFRPIHAAISLVGEPTLYPYIDDLIYEFFKHNFKTVFLVSNGTRPD
VLEKLNNEPSQLYISLSAPDYETYRKVCRPKIPNGWENIMRSMELIKSFSCPTVIRLTLV
KELNLKKVEDYARIIDKANPTYVEPKAAMSLGGFQYRLSSTHMPSFEEILEFGKKMSELT
SLKIIDASESSRIVLLSRLDKPIKLI
>A0A7J2TPK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVRLETLVPSALIQALKKQKYHFVGRHSAVKRCRWLYETLIHDRPCYKQKFYGIKTHQCI
QMTPAAFFCTQQCLFCWRAQTDDLQITWNEMKLPPWDSPEEIVDGSIKAQLKILSGYKGN
PKANKRKFMEALTPKHAAISLTGEPTLYENIGELIKAFHRRGFTTFLVSNGTLPSVLAKL
REEPTQLYISVCAPDEESFKNVCRPQIPKAWEKMNETLSLLPSFKCPTVIRITSVRGLNM
KNIEGYAKLITKANPTYIEPKAYMHVGFSRLRLGYEHMPSLAEIVEFGRQLATETGYFII
DKSAESRVLLLGRIEKPIRFGNG
>A0A6A6BM12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aplosporella prunicola CBS 121167|TrEMBL
MAATTLSWALPDDLLAIWHTSRVPILLAVATILTLIRLTQRLRTSNREKLSASPIPGSPQ
AGPEKKDRSLEIAARWVNADGVVPEKAKPLEDDHLEDITVAEPPLVRPKPGPKKVTGSKV
PKAKRTISFDATRDKVQPLVFFSSLGGSTEARAKQLVEDFGAWTDALALESENAPLPLKP
ILHDLSYIEYDDFFISAPKTDENIKYFYIVLVPTYNIDTALDAFIEHLQETHHDFRIDTA
PLSGILGYAVFGFGDKEGWATEEEGFCSQGKDVDKWLARLTGRRRAFPLGIGDVKSDVVE
RLKEWRLGVQEVLLDVASGKGLGEGVPGSGDALESDEEDTEDEDGEEETQPSKPRKTKPK
SDLNDVEDLGRMVQTDASPEEPMEIDFTTYKTKPAKTSQPAPKEMVPKTSPTYSALTKQG
YTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWQVDPPEEIYKGVTEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPYINEFTKMLHDDHISSFLVCNAQHPAQLATLKPVTQLYVSIDASNKESLRKVDRPL
NRDFWERFCACLDILREKRFEQRTVFRLTLVKGFNLEDEVAGYADLVARGLPCFVEIKGV
TFCGTSTSAAAGLTMQNVPFYAEVQTFVTALNDALAERGLEYGIAAEHAHSCCVLLASTR
FRRRGADGELKWCTLIDYERFFELLESGEPFKPEDYMGEATPEWALWGNGGFNPEDERVY
RKGKNRDRSDAGPAVVEI
>A0A2D7ASK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGKFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELSDQDPLEMLYDSVKAQRRLLSGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYKNLSEYMELCHSHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKEVFDEICRPKWNSAAWDKFDQTIDLLPSLDTRIVCRHTLIKGRNMKPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILEFSRALAPLTDRKLLDDSAPSRVALV
GREIVPIPIPEATMEFPKDLGIAESIKHLKIVQ
>A0A2E1SNR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDSLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPKEKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSSHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNRDVLSESRPSRVALI
GREIVPIPIPEAELYFPDDLGIAPPVKKLPLIQN
>A0A7J2NI09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
METGTDTVLEWQGYKLVGKYGAVKGCHWLREKLLRGKPCYKEQFYGIESHRCMQMTPVVN
ICNCQCLFCWRFHGMKEYPSPDMDDPEALIEGMLAAQKEIVSGFGGDSRCEPEMWEESKS
PTNVAISLSGEPTLYPRLSDLIEACHKRGTTTFLVTNGTNPRALDDLDVLPTQLYVTIAA
PTREIFEKLCIPRSSRLWDRLMETVSMLPSLDTRKVIRHTLVSNWNMGWESEYAALVERS
EADFVECKAYMFVGDSRNRLAVENMPSHRDIRTFSERLCAENSYELLDEHRDSRVVLLTR
NQRKARLAF
>A0A2E4B1A4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPGLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVTPEKFKEAQNP
KHVAISLNGEPTLYTKLGEYMELCXKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDEVCRPKWGNGAWDQFEKTIDXLPSLDTRIVCRHTMMKGINMSSEHIKQFAALDN
RADPDWIEAKGYVYVGHSRENLSMENMPSHEDILNFSNELAPQVDRRVLSESRPSRVALI
GREIVPIPLPDPEMFFPEDLGIAPPTKKLPLIQN
>A0A2E3FR27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACTYCWREPHMDTLKLTEQDPLDMLYDSVKAQRRLLSGFGGNPKVPKEKWLDAQNP
KHVAISLNGEPTLYTRLSEYIELCHAHGMTTMLVTNGTLPKVLERLDTLPTQLYVSVDAP
NEEVFNEICRPKWNSASWKYFDQTIDLLPSLDTRIVCRHTLIKGKNMKKEHIKQYAALDN
RADPDWIECKGYVHVGNSRGNLTAENMPFHNDILEFSNALAPLTDRRLLDHSPPSRVALV
GREIIPIPIPEATMHFPKNLGIAQSVKHLKIVQ
>A0A534KCT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPEKKDVLERQGYRIVGEHSGVKLCHWTKASLTKGIGCYKQTFYGIESHRCLQMTPTVD
ACNLSCQFCWRTQEWGSDSLLEADDPVFLVDESIRAQRELLSGYNGNPNVSRERFLEAWH
PSNVAISLTGEPTLYKRLGEMIDEFKRRHISTFLVTNGTTPSVLRRMHAEGRLPTQLYVT
VAAPNEEVYRKLVAPKSDHEFRKLRETLALLPTLPTRTVIRHTLVQGWNLGWEDEYAELD
RVAQPMFIECKGYSFVGESRLRLQADNVPSHASIRTFAERLADRVGYRPAAEREDSRVVL
LTRDGQLHPLPR
>A0A3M1HFV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MESKDRQQDAKIDGKVSFNPRQREKWEKVYGIVGHHSAVHICKWTKDSLTSATTCYKNKF
YGIDTHKCAEMTPSAAWCQEACVFCWRPMEWYSRTSMEEEEVDEPAYIIDSVVEQRKKLL
SGFGGNANVPRELFDNVFNSFPSHWAISLSGEPTIYPLIGKLISELRSREGVKSIFLVSN
GQDSSVFLKMKKEDSLPTQLYISLDAPNEGLFKRINRSIYDDGWERLLATLRLLPSLPTR
RVIRYTLIKGLNDKEEHIEEYAKLYNIAKPDYIEVKSYMFLGQSRKRLVMENMADHDYIR
AFSESLLSHLPDYEWRNEEESSRIVLLKRKDSPFKDIIRAPHPLHSLREGAEKPSEWGVQ
>A0A7J2Y4X6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDSERKEVLERQGYRIVGEHSGVKLCHWTKASLTRGIGCYKQTFYGIESHRCLQMTPTVD
ACNLGCIFCWRTQEWGSDSLIEADDPGFVVEESLRAQRELLSGFKGNPEVPRERFLEAWH
PNQVAISLTGEPTLYRRLGEMIDEFKRRNMTTFLVTNGTTPAVLRRMASEGRLPTQLYVT
VAAPTEDVYRRLMAPKSDHEWAKLRETLELLPTLDTRTVIRHTLVEGWNLGWEDEYAALD
AIAKPMFIECKGYSFVGESRLRLRADNMPSHASIRTFAGRLADRVGYAIAAEREDSRVVL
LTQDGGLHPITA
>A0A812WNU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium necroappetens|TrEMBL
MGSCTSQRQLADGHRFQDIEDLDLLFGSKPSTSSPSVVPAVPRGGVEARSADASWVKRLR
QERVRPLYRSGELKAVHLELTTRCNAACPQCPRNLQGGVENPVLAAHHSELSLEDVRAIL
PPGFLRQLRKVYLCGNFGDPAVAQDCAEVIRYLLSVGGSRVGLFTNGGARSPVWWEELGS
IMQPPERAFVRFAIDGDESTNHLYRQHVRWERLMANVDAFLAAGGNAEWDFIVFEHNEHQ
VEAMRSLAEQKGFTKFNAKKTARFIDKARGAVKPSVPVKDTSGSVVRTLRPPANPAWQNE
AALESVQKAVEKYGSIEAYYDSCEISCKVAKEKEVYISADGLAFPCCWLAAEMYRADLPN
SGREVVRLAKAAFPQEGLHALSALRRGVGAAVDRRAGLFQQLVPAAMRQPSLREGRLRTC
SGVCGVEVNAFAKQFAGATQPLDPVRRSRAASAATVAPAPVEGSPVEVWYGSETGTAEQL
ALRAAEALGSEAAVSVPPPWDQVEARLHGCRALVLVLATWGQGEPTEDAQGLFRFLRERR
GKAKRVFPPLPVAIFGLGSSLWPHFNAAAREAEELIRSLGAPILIRLGEGDAAKGHLDSD
FDAWLQELLVALKKLGLDSSGGPPRVRRSTDSVSILPMTVVRVTRLAPRDPVAREAAMAM
TIDCGKLVSKFNSPPAAMSLKVDGIVRAELQEELATPNRLAGGEMDGVLAYALKMFLKVE
EARIDPGMNVGSDIMKVPVPELGQMLPPPQPHSVQRPPKDPRFRPIPLADRANIVFSKGS
VGHPFSCAAACRYVKRKGGCRRGADCNLCHECFWSKDSEMWEQPQAQEEKVAQAGPVFIP
SQEDVTDEFAGLLSEVCMLQPLPQQESYPASAFLGSMDSAVGMEGFAGVEMPAMNPGSLG
HPHSCGPACKYAQKSRGCKDGDMCRRLCAEVVFPFDRLVLTSGRCQASHRREKDDFPHHP
ALCYTAAEPLHVHEEDRDGDGLPVLFAAAWAQTPQPQEAEGSRILPDTCQESRTEQQGTS
SNVHIATASTDVLAALLSEDSIPELSGKLELRYPPPPERVRCDLEELSADFCEGCGREVL
RLLVREVSGGVCSPYLCGLRPGAVVECLAPRRRSPLRAAWEAREASRLLLVANGAGLAPF
LALLEQLSVSDSRPLYLWLGCRRRSGGLLYEERLEALEAQGALQRLSVAESRPLAAGEAQ
KPWVQDLLKAESEQVGQLLFGSPTQPGTGLMLVCGSAAMGCAV
>T1J2J5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigamia maritima|TrEMBL
MEAVWNFTWKTMRVLFFLLFFVVNFVRVNSEDGELEVGNDDNYFCWTNIFTTIIFAVCAS
FSFKLAFETGSMEKKIAARRLSKPCNTKSNCECENKSNSCCQQKQTDKTIQIFFATQTGT
SIKFAELLKDFLQEKGFNYTLSNLKDFESEEKLLELAKNKHICVFILSTYTDGGPPEEIQ
WFYQWLNDTVNDFRVQKSLLKGMRYSVAKNVDQWMHEMQAQRLMPLGLGDENVAESEKGG
IEHDFDEWQKKFISILHKMQLSSTECCDQPAEVVTEDEEIQYEDTSDEEDSSKDEKELVD
VEDLGVVVSRKNVKKSTDVREMITPTLRTALTKQGYRLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIASHQCMETTPSLACANKCVFCWRHHSNPVGTEWKWKMDQPETILDRAMQAH
YKMINEFKGVPGVKDYRIAEGMKIRHCALSLVGEPIMYPEINKFVSLLHSHGISSFLVTN
AQFPDAIKDLVPVTQLYVSVDASTKDSLKKIDRPLFSDFWPRFLASLKALSDKGQRTVYR
LTLVKAWNVEELAAYAELVTMGNPDFIEIKGVTYCGTSKASKLTMENVPWHEEVVEFGKK
LINLLPEYGLACEHAHSNCILMANKKFQINGEWHTWIDYDKFHELIKDPAIISGEKTFNS
LNYVAQTPYWAVYGSDKQGFDPDETRWYRKNNKDISGC
>A0A6A6JAN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Westerdykella ornata|TrEMBL
MAAGDFFEQLPAELLLIWHTLRIPLLLSAAALIAVARYVRHRSTAIKIVKIESPTEEKKI
ELRPEWLPENTTLLPGQQIATSLSKSSKPKKVPKIVRGQKKSPTRAQQKTAPVFNHTTDK
IQPLVFFQSLSGTTERYASQLAKTLNDWIADAKPGASILEPQVHDISYIEYDDYFVSPPK
SEDGTIKYFYLILLPSYNIDTVLQNFLDNLQETHNDFRIDTAPLSGLLGYSVFGFGDKEG
WPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGDADARLEEWRTGVQEALLEIAA
GRGLGEGVPGSGDAVESDEEDLDSAEGSDVEPVPNKPQKPKKNTQRVDDLEDLGRMMNST
STSPASSTSSPIPIDFTTYTSTPSKPTTSTLPLKEMVPTSSPTHKALTKQGYTIIGSHSG
VKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRW
VTDPPEMIFDGITAAHYRKIKTMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINAL
INLMHSQRISTFLVCNAQHPAQLQSLVPVTQLYVSIDASDKESLRKIDRPLHRDFWDRFI
ACLDILRQRRFEQRTVFRLTLVKGFNMADEVRGYADLVQRALPGFVEVKGVTFCGTSTAG
SAGLTMANVPFYEEVAEFVRQLAAELGRRGLPYGIAAEHAHSCCVLLADGERFKRNGRWA
TRIDYERFFDLYEGKVQGSRMQGGKVVGWRPEDYIGDETPEWALWENGGFDPRDVRVWRK
GKGPKAVKEQGEAENERDKAVAVEI
>A0A7R9CMD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema poppense|TrEMBL
MITIFGVPFFGASFIPTLVAVATIYIAWSWFAKKQNGNKICSLEAIDAVTTDSLSRQVVE
NGKGPLISIGDKVGPRKIVAKARKKSCGGKGGKCCGSKKGKSKCLTIEGVIDRLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEERGPRGGLLTSNPHLHTDKPL
RGLTTHSAFQHRGRCPGDTARRHPERGFPREHLRARPGRWVSPQGIDNPLCQQHQREHNT
SPTSGKSLCVFVLPTHAEGKPPEAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQ
YADHFNEVGRSVDHWLHKLQAVRVAKLGAGDEDTAASRYGSIEADFDNWQNSLMGCVEKW
RAKSNCRCGGKSQPQEERIEEASSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNF
SSALRAARERKESGESVGTREMITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGG
CYKHSFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALDAH
YKMINQFKGVPGVKPERLAEGFQAKHCALSLVGEPIMYPEINKFVKLLHQKEISSFLVTN
AQFPEAIREMSPVTQLYVSVDASTKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYR
LTLVKAWNVDELENYAKLVEIGKPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQK
LAYLLPEYAIASEHEHSNCVLVAHKKFQVDGEWMTWIDYEKFHELVQKFYSTNGESSFTA
LDYMRKTPDWAVYGSSEQGFDPVETRWHRKSNTKDISGC
>A0A7C4KXL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylicus sp|TrEMBL
MNKELLKILKSQGYQIVGRHSAVKTCHWVRKAITKGEICYKGKFYGIKTHRCLQMSPSVV
YCTNRCIYCWRILPGERGIIWNGNSLYEEDDPEFIAKESINAHRRALTGYKGNPKAKKEI
LEEAMNPKHVAISLSGEPTLYSKISELIEEYHKMGMTTFLVTNGTRPEVLEKIKEPTQLY
ISLSASSEEIYKKVCRPVYEDNWNKLIKSISLLRSFKCPTVIRITLIRNLNMEDIDGYAK
IIKIGLPKYIEVKAYMHVGCSIWRLGENVMPTHEEILLFSRKLAEKINYEIIDEVPASRV
VLLKR
>A0A7K4B5I0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MHSGQCEPSMKALRGMGYQFFHPQSSAALKPCLWCKRSLSGGDQCYKNQFYGITSHRCVQ
LTPTLRCNHTCLFCWRSFEHEYTGEKDLMPEEIVSRIPFLQKKALGGYKVSPRVAKEKWE
EALRPDQYAISLAGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPGVLRQCHPYQKYISL
TAPDRETYLRIARPVEDYWDQILESISDLGHETDAGRRTAIRVTLVRGINDQDPERYARI
IQESGAKFVEVKAYMHVGYSQKRLTIRHMPLHDEIDRFTRKMLPHLSYRILGENTLSRVI
CLEQDL
>A0A7K4A5Q6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MLSSPCKALRSQGYQFFSPESSAAVKPCLWCKKALKGGEQCYKHQFYGIESHRCIQMTPT
LRCNHRCLFCWRSFEHEYPGERECTPEEILAGLYDLQKRALSGYKVSPYVTSERFAEALR
PAHVAISLSGEPTLYSHLPELIDLLKDRGFTTFLVSNGTNPDMLSRCLPYQTYVSLPAPD
KETYLSICRPAADYWDQICRSLTLLSSRRSAVRVTLVRGLNDHSPEKYAALFEKSDARYI
EIKGYMYLGYSRKRLSREHMPAHAYIKEFAERIAEYGNYRITNENAPSRVVLMENTA
>A0A7K4MYM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVSDHSTVELCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYETMEMKPENVAEPEEIMTNLMAERRKLIM
GHYGDPNQDKKKLDESLLPSHYSISLSGEPTMYPKLPALIKYLKSLEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYESFLKINRPRYDDSWERWNRTLKMLSTLDTRTVL
RITLIRGYNDDEEMIPAFASLLQKSNTHFVEIKSYMHIGRSTNRLEHSDMLEMSEVRSFA
NKLAQENSDFTVMDESGISRIVILQNKKRFVDRFIPACC
>A0A6A5QWM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ampelomyces quisqualis|TrEMBL
MSLPNKWAQLPAELLLIWHHHRFSVLFSAVAFAAIVRLAIYARSRRQKISNSPVPGSPVE
KKDIELRPEWLPENTTLNTSCLNVDGHAEDVSSLGATVLKKKRGPKTVKGRRTAKKSPVP
ASCFDHNTDKIQPIIFFQSLSGITERFATDFVKIFTDWTTGCDQSRIFLQPDVYDISYIE
YDDYFISPPKVEENTRLFYIILLPTYNIDTVLDNFLENLQETHNDFRIDTAPLRSLLGYS
VFGFGDKEGWPTEEEGFCSQAREVDKWMAKLTGRKRAYPLGMGDTKKDAAARLQEWRVGV
QEALVEIAEGRGLGDGIPGSGDPAESDEEEDLEDSNGQSKRVEEIEELGSMVDSSSTTIP
VDYTTYKSKSKLLVKSTVAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDGIT
AAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLNIMHSNRISTFL
VCNAQHPAQLASLVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGTAGLTMQNVPFYE
EVAEFVTELEKELNSRGLTYGIGAEHAHSCCVLLADKTRFMPNGKWATRIDFERFFDLYE
GKVEGTRLEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDQRVWRKGKGPKADEGEKRG
EVERKKMEELEF
>W0I5J7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus paralvinellae|TrEMBL
MSETIKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKHNRVCYKQRFYGIHSHRC
LQMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLSGFGGIKDR
INVKKFGEAQEPKHAAISLSGEPTIYPYIGDLVEEFHKRGFTTFIVTNGTVPEAIEQMKK
ENKLPTQLYVSLTAPDIETYNRVNIPMIPDGWERILKTLELMRDLPTRTVIRLTLVKDEN
MHNPKGYAELIMKAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEELVKYLPGYH
IEDEYQPSRVVLIMRDDISKEERFIKH
>A0A8D5ZHC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobales archaeon HS-7|TrEMBL
MICALTQDAYSFLFRELEKQRYHIIGSHSVYKKCHWTHEAITKNRFCYKGKFYGIESHRC
AQMSPSALWCWFRCEHCWRLEPEDVGLDWDETKIPTEDDPELIAEKSIEEHIRSVSGYYG
MKGVNKEKVKEAEDVKHVAISLTGEPTLYERIGELIKEYHKRGITTFLVTSGVRPDILAN
LEEEPTQLFVSLQAPNEYKHKIFNRPIIANSWNLVMKTLRILPSFSCPTVIRLTMINGFN
MSDKDAEEFAKLFEIAKPTYIEVKAYMHVGPSTLRLSKDAMPRHNEIRLFAEKLAELTGY
NILSEHIPSRIVLLSQLNRPIKIGNAWSDSWNWSTRDLEDDVSGEYREAETSCTEGQI
>M4C2B5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyaloperonospora arabidopsidis (strain Emoy2)|TrEMBL
MLSPAASAGVSLLLVATSVLLYLSVQLRPLSIDAAAISCKKKAKKSSSCKPKSDPPQPLT
VRILYGTQTGVSKTMAETLQKSLFALNIANFYFQTSVVNMKDYDQDNLEQEAIVVAILST
WTHGNPPEDARVFCNWITDMTQDFRVSKSWLNGVPHAVFGLGNAEYDEDHATAAKNLDRD
LSNLGSPSLVGLGLGDDNVDQFKQFDIWMDNLIAAMCEFSSEKAAAALKEGGNGVKDAEK
AGKKEWLSQNEFRRLKRAGKVEAAAANGESVEPNEEDRMNEQFLVDEFSDDEEQNAQSTN
DEDGMVDVEDIGKSMKESEAANMSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQL
RGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKMDDAETLVKG
SIERHQSMIKELKGLPGLIPARWEEAFTVRHCALSLVGEAIMYPQINEFCRQLHNRHISS
FLVTNAQFPEKIAALDPITQLYVSVDAGTKESLRAVDRPLFKDFWERFLACLEELKHKGQ
RTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSNLTMKNVPWHEEVR
GFCSALCGRVSGDYALASEHAHSNCVLIAKKKFCRDGMWHTWIDFPRFHELVTKFYEDGT
PFTADDYTAPTPHWALYNSKEQGFDPVETRFRRTRDGKVVEFAYQSTESGCG
>G7P1P8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca fascicularis|TrEMBL
LDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A6A6MBV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hevea brasiliensis|TrEMBL
MSLSSAYARLTLLALLSASTFYCFYKSRRLKLLKISLNPKDNLNANPISSSNKGKLFFIS
QTGTSKTLAQRLHNLFKLNDLLFDLIDIKDYEPEDLSKETVVIIIASTWEDGKPPSNASF
FANWLADSADDFRVGSLLLSKCKFAVFGVGSTAYGGTFNAVAKDFSRRLRELGANEIVEV
GKGDVDGGELDGIFDQWSGKVLRILKGGSMQNGLVFSNGCTGGESDNENIEDGFESEDDE
NGDVESGIVDLEDIAGKGPSRRSNTVAEVNGKANGQKEMGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKNWQWKMDDPLEIVNS
AIDQHTKMIKQMKGVPGVTQERLTEGLSPRHCALSLVGEPIMYPEINKLVDELHRRQIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKSLKEKQQ
RTVYRLTLVKGWNTEDVDAYFNLFKIGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVK
AFSEALALKSKGEYEVACEHAHSCCVLLAKTEKFKVNGQWFTWIDYESFHDLVASGKPFN
SMDYMAATPSWAVYGAQEGGFDPDQSRYRKERHHRSSH
>A0A1J4VV28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon CG1_02_31_27|TrEMBL
MKLATPTEIAENLKHKHYGLSKHGAVQICLWTKKALRNEGVCYKEKFYDAHCHRCMEMTP
LAVWCNQNCIFCWRPSEWLNLNDLKKELEKPEEMVEKLIEKRKKLLSGFGGSVKKYKTER
LFKESLIPDHFAISLSGEPTLYKKLPGLIKLLKEKYKARTVFLVTNGSQPEMLLKLQKER
ALPIQLYISFESPNENDFLKTNKPRSKNAWKTLMRTFSILPKLDVRKVIRITLMKNINDS
EEKIKQFSMIINESFADFVELKSYMHVGSSRERLKKENMLEHKEIKEISKKFLKYLKNFR
YEDEQKESRIVLLKNKKSPYKTKFD
>A0A8H3NEN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus udagawae|TrEMBL
MAEHPITEGLLAFWHSYRLLFLVALSTVFLGLRFYRILQSRTKTTASSSIPPSPRSQSPE
KTDKGTSLKSSNPATTQKAERQLPLANGPAKGTSGPKRVTGKKPSKVAGRQGQTEDAEPL
SFIQPIIFFASLTGTTERYAKILFEELRAAAQKRADLQDRERGLLPPQIHDLSYIDLDDY
FTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTVLDHLNETHNDFRIDTGSLSNLAGYSV
FGLGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGLGDVKSDAESSLKEWSQGLQ
DILFDILENGGLGEGVPGSGDPVESDEEVDDEDVDKSNAQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSGQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFEGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGERISSFLVC
NAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTFCGTSTSAGAGLTMQNVPFYEEV
AQFVTALDAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKEK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDKRVYTKGKKKNMQITVEP
>A0A7J8LDF6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium lobatum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGEDIVDLEDI
AGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTA
IDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTF
LVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQR
TVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVRA
FSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFDS
DDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A7K4C254|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus bourgensis|TrEMBL
MHSEACKALRRQGYQFVSPSSSAAVKPCMWNKRALRGGEMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVVEEEECPPAEIIGNLRRLQKRALSGYKVSPYVTPERFAEALR
PTMVAISLSGEPTCYSHLPELIDGLNAEGYTTFLVSNGTHPDVLARCRPYLVYVSLDAPD
RETYLRLCRPREDYWDLVQESLAGLAGRRSAIRTTVVRGYNDFAPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRDQMPEHRDVRAFAAKIADHCDYFIKDESPVSRVVCLERNV
>A0A7L2AZL6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Heliornis fulica|TrEMBL
IGDKLVDGYVSLQAKNICVAGVKIFYGSQTGTAKRFAQHLAETVISFNLPVEVISMGDYD
PDDHLVEETSGRNICVFLVSTYTDGQPSESAAWFCKWLEEAAHDFRFGQMYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
SRLQALCRGEKKPCSGKCKKGKCKSPGKQSEESSDCEHGASEYENTEAEELFETSSEEEA
DAEEAGGASSVIDVEDLGNIVSHMRKAKVPLSTQENAGRKEEGEKREMITLALREALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRLAEAMSVRHCALSLVGE
PIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRP
LFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEVKGVTY
CGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKTDGEWY
TWINYSRFQELVHEHESSGGSKTFTAADYTAKTPRWALFRSRERGFDPSDIRYQRKNKAR
DISGC
>A0A843HV31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp|TrEMBL
MKELEKEKYHLIGSHSAYKKCYWTHEAITENRYCYKGKFYGIESDKCVQMTPSAAWCWFR
CIHCWRLEPEDIGLEWDETKIPFMDDPEYIVERSIEEHKKALSGYLGREGVDPKKVKEAL
QPRHVAISLTGEPTLYEKLGDLIAEYHKRGLTTFLVTSGVRPDILANLTEEPTQLFVSLQ
APNEKKHKLMNRSIVANSWNLVLETLKILPSFSSPTVIRMTMIKGFNMSNEDVKDFAKLI
EIAMPTYIEVKAYMHVGPSIYRLSKDAMPRHYEIREFAKILGELTGYKILSEYPQSRIAL
LSKLDRPIQIGNAWSDKWNWSTVEPEDDINWEYKEAEDD
>A0A7G9Z419|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-1 ERB7|TrEMBL
MEPKAILNYHEATLEKQGYHFVAPHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAHRCV
QMTPCIFCNQRCIHCWRPLEAFNMGEVDIAWDTPLEIVEGCMKEQRRLISGFKGSSKTSK
AAFAEAEEPKHAAISLIGEPTLYPHLQELIQEFHSHGMTTFVVTNGTNPAVLREIHPSQL
YISLNAPDETIYKRVAHADYWTQIQESLEVMKRMKERTVIRITAMAGTNMVDPGGYAKLL
ETANPDFVEVKAYMHIGYSRKRLSRAVMPSHTEVKEFAGEIAEHLTSSGYDYKIVDESEI
SRVVLISNLSSEVKALPKL
>A0A8C7YDS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias sinensis|TrEMBL
MFNFSLRLCFQKSGEKDAVSGAIKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKAL
GFPAEVIDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRY
GRTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGS
VQADFQAWKGKFLSRLQALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEVRRREE
DGEVVKFSKLNGVKKIDDDDGERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDA
LEKHQDMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSF
LVTNAQFPEEIRSLEPVTQLYVSVDASTKESLKKIDRPLFKDFWPRFLDSLKALGEKRQR
TVYRLTLVKAWNVEEMQAYAELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVA
FVQQLAAMLPEYEVACEHEHSNCLLIAHKKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQ
TFSALDYMARTPSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A2D6PAU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MQIKVKKLLEKQGYRIIGKHTAIKICLWCKKAIRNENTCYKHKFYGIKSWRCIQMSPAFL
NCLHRCQFCWRYLDYTLAKDVEKPDDPNTIIDGCINAQREILQGFLGNKKIGKKRFYEAM
NPKHFALSLAGDACMYPKLPQFIDEIHKRKMTTFLVTNGTKPEMLKKLLKHKPTQLYITL
PAPNKKIYKKICKPTIKDGWERLMESLNLMKNFNRPTIRLTLAKELNMCNVKDYANIIKD
LNFKFLECKAAMPVGYARHRITYEQMPTHKELRTFTTKLAELLKLKIIDEKEESRVFLLS
KKDSADRKLFK
>A0A2D6LVY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MKTLEKQGYRLTGKHSAVKICNWTRESIRNKGVCYKQEFYGIKSHECCQMTPCLTCNNSC
TFCWRSTKNLTGTKLEPPIDTPEQIINNCIQQQKQLLIGFKGYKNTNQKKLQESFKPSLF
AISLTGEPTIYPYLKELIQELKKRKIKSFLVTNGQFPDKLKDLNPTQLYLSLDAPNKEIY
KELDKPLFKDYWERLLKSLKILSKTKTRTCIRITAIKDINMCNLEQYANLIKIANPKFVE
IKGYMWIGESRKILKKENMPFHEDVLNFSEKLAKILNWKVIKQKKESRAVLLMKEDKDRL
VY
>A0A7J3DJV4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MVVKIPDFVREKLKHMHYGIAGNHSAVEICAWTKKALRGKGVCYKQKFYGIECHRCAQMS
PAAVWCQQNCIFCWRPMEFMKNIKMKSEEVDTPKEIIEKVVEQRKRLLSGIGGAYDVKSK
LWKESFELFPSHWAISLSGEPTLYPSLPELVKELKKHKEVKSIFIVTNGQEPGMIERLWK
ENALPHQLYISLDAPNKTLFKKINKSLYKDGWGRVKKTLSLVAKIPTRRVIRFTVIKGLN
DDEKYLPAYAKLFEKSKADFIEVKAYMWLGYSRKRLKIENMPRHHEIKNLAENLLKFLPN
YEYMDEQEESRIVVLKRKGSRFGRWLIFENFRNI
>A0A7L0B203|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ciconia maguari|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYSAVAFGISVWIVIQFTTTKTKKKVTECVRIEDKL
VNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAEGLAEAVISLNLPVEVISMGDYDPDDCL
SEETTSKNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWMWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSRLQA
LCRGEKKPCSGKCKKGKCKSSGKQSKESSDHERGASEYENTEAEELFETSSEEEADAEEA
GGTHSVIDVEDLGNIMSHMKKAKRERELEEGDVGTSLTQEDAGRKEEGEKREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCAL
SLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEV
KGVTYCGESSASNLTMANVPWHEEVVRFARELADLTPDYETACEHEHSNCLLIAHKKFKI
NGEWCTWINYDRFQELVQEHERSGGSKTFTAADYAAKTPRWALFGSRERGFDPLDIRYQR
KNKVRDISGC
>A0A833A115|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus okinawensis|TrEMBL
MSFNNPYIPQEIYEILRKQRYQIRDHSAVKLCGWVKKSLLENKSCYKSKFYGIETHRCIQ
CTPSVIWCQQSCIFCWRVLPSDIGISKISYDNIKWKEPEEVLEDILEMHRKVVMGYKGIL
DRIGREKFEELLNPRHVAISLSGEPTLYPYLEELINLFHKRGFSTFVVSNGILTEVIQEI
NPTQLYISLDAYDLESYRRICRGREEYWQSILETLDTLRSKERTCIRTTLIRGYNTDIEK
FIPLYERADVHFIELKSYMNVGYSRRRLALEHMLKHEEILELARRVEELSHYKLEDDSFD
SKVALLVNEDRRIERFIK
>A0A665U0U4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
MTCLSTVSQNEHGTSESWFMSVWHNRLYLYSAVALVFGVWFSLNMALKKKSISKDINPWV
YKAVKIQNCPDRAAVVHVSGVKIFYGSQTGTAKGFAKELSEEVTNLGIPSEVIDMKDYDP
DDQLPDECTSKSVCVFLVATYTDGQPTENAEWFYRWLEEASTDFRYGKTYLKGLRYAVFG
LGNSVYVGHYNTVCKNVDKWLWMLSGMRVMTRGEGDCNVVKSHNGSIQADFQAWKVKFLN
RLQALAKNEKSCSGNCKTGSSCKNKRNDGQLEVEKENDDLIESTSDEDESGLQDEKKSGA
VVDMEDLGSMMNIARKAKYLIYCDSDKSKLGLSKFTAVKKLADEEERREMITPALKEALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWHWKMDPAEKILQDSLEKHQNMIRQFRGVPGVRPERYEEGLAVKHCALSLV
GEPIMYPEINTFIRLLHSHQISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAMGQPDFIEVKGV
TYCGESSASNLTMANVPWHQEVVAFVQQLAGMLPQYEIACEHEHSNCLLIAHTKFKVDGE
WWTWIDYQRFQELAHVHEESGGLQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNK
TKDISGC
>A0A3M7MDN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora seminiperda CCB06|TrEMBL
MCTMVFLRYAEQLPAELVHIWHEHRLEILLSALVVATIARLAIYSRDRRRDKVSQSPIPL
SPVEKQTVELKPEWLPEYTTTLSPPLLNVDNHAEEGTAAVQKVAKAKKSPKTVKGRKIQK
KSPAPASTFDHKADKIQPLVFFQSLAGTTERYAAELTKTLTEWTAGCDQSTSFLEPQSHD
ISYIEHDDYFISPPKVDSHVKHFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSG
LLGYSVFGFGDKEGWPTEEEGFCSQAREVDKWMAKLTGRKRAYPLGMADVKSEAKERLQE
WRIGVQEALVEIAEGRGLGEGVPGSGDPAESDEEDVEDVDDGGGQGTRVDDVEDLGSMVN
STSAPIPVDFTTYKKPATKSKHVQIPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWT
KSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDL
IFDGITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPYINELLAIMHKN
RISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILR
NRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQ
NVPFYEEVAEFVTELEKELNARGLQYGIGAEHAHSCCILLADKTRFRKGNGRWATRIDFE
RFFDLYEGRVEGSRVEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKA
VKEEGEVEEGKSEVKVGRAAAGALEF
>A0A2V2V2N0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi|TrEMBL
MTESISEALWWVLLGALIPLVTLTLTTLLDRWVSRRRKRQMEVARAQAAKEGKTTWMEPN
VHNSTGKTNGNGSTIHDAVKGSKGRVDVKKILIAYATQSNTACKLAHKLFSTLSTTLHES
RDEMQGGSSSCVCSEGSSSCCATSHTARHLPELKVLQLTEEGRQCGVEHLLESQAYGLVI
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKFAIFGLGDIAYGEKHFNRFA
KNLYMWCKGLGATFVVPPVYASEANTIPLFNVFTASLVKWVGRVTFTADGVTILKRQQKQ
LKEKKEKGQIKLCNDVELQGNATYNSEEDEEEEEREEEDEETGRKKRNHNSEGDVEDVVT
DDEDEGEDVNGQSGSVDHAVQALSSEPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTK
AMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRTFRWKVDPPQLL
LAEGIAGHQKMMKQMRGVPGVTPERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHEQG
ISSFMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRR
KPQRTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLTMKENVPRH
EEVVRFCAALCEALACDTAPRDKRTWLGTEPKTGPLQRDPNFDEKRTSVNNMENNSSRCN
RKDEEEGVGINFSGPYSIACEHEHSCCVLIALRRFLVNGVWHTWIDYEKFNALARSGRTD
FTAAEYAAPTPSWAVFRSNEKGFDPTQVRVYRKSGNTTVVTSGC
>A0A5E4I9K5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MNPELQKILKRQHYAIIGKHSGVKLCHWMKQSLLFGRECYKQTFYGINSHRCLQMTPAIT
HCTQMCLFCWRFQNFTEKELHDIDDPGYILDHAIEAQKKLITGFKGDPRCDQKKWKEANE
PNMLACSLSGEPTLYPKLGEFFEACHQKGITTFLVTNGTTPAALEKLDPLPKQLYVSVVA
PTEELYKKICAPLIPNGWENIQRTLALLPSLGTRIVIRHTLIHDWNMDEKYIEAYAKLDA
RASPTFIEPKGYVFVGSSRNRLHFSNMPPYDQIKNFGQKLAEQLGYEQVMEKADSLVVLL
SSQQKNRKVK
>A0A5E4KJL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MTSISSATQALLKKHGYHLAGTHGAVKTCLWLNKSLRSEGGCYKAKFYGIASHRCVQMTP
TLVCNHRCLHCWRAIEVQTEVPEKWDSPEDIVKDCLAEHRRLVSGYGGSEVMNRAKWKEA
FVPKHVAISLSGEPTIYPYLPELIDAFHKKNMTTFVVSNGTNPQMLKQICPTQLYISLNA
PDEDTYEKVCAPLGDTWENIQQSLEAMKESKTRTAVRITLTRDVNMIDPEGYAHLIKLAE
PDYVELKAYMHLGFSRKRLSRDNMPSHYDVRIFSEHVADALGYCIADESEASRVVLLSKD
GKKCSVV
>A0A5E4IQC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MPDTEKQKRLKNQGYRLIGKNAAVKLCHYTKKTIRGEYACYKNKFYGISSECCLQLAPCV
GNCTHHCTFCWRSVDYSPLPPKQSETDSPDEIILSALFGQQKLISGFGGSPELIDKEVYA
RAKTVKHVAISLAGEPTMYPNLGELIQKFHERGISTFLVTNGMFPEVLNSLGSTNSLPTQ
LYISVYGPDEKTYKEITRSALKDSWQRLSSSLKILGSFKGKTRTAIRLTLVKGANMFSPE
KYADLLRVANPDYVECKGYVHVGGSMANLGAENMPSHSEIKEFALQLAKEMNYSYKDEAE
ISRVVLLVRDPSKSTFIPGFEKNVCKKQPNPRGENLFETDL
>A0A0V0SFW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella nelsoni|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVFDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLNKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVCEVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDICERCVMIHFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVG
THSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPKWKWKTDPAEKILSDSLEGHK
KMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNA
QFPSAIKNLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILREKKQRTVYRL
TLVNRYNMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKDSKITMANVPWHADVVDFVQQL
VFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDY
MAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A6G8T3A0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. JP-L23|TrEMBL
MSESDDGPKQVSDPAYHSQNHTAAQTCGWTKNAIQGDGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQKRLLSGFGGNENVPRDVFEQA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTNPEMLAECDPTQLYVSVDA
ADRQTFDATVKAVEDDAWDSLVDTLDVLAGKDDTRTVVRTTLVKGHNMHHPEWYAAMCDR
ADVDFVEMKAYMHVGHSRGRLDRDSMPSHEDVRAFTEEMQAFLPDHDVLKEVEESRVAML
AEDEQTWVPKLEKSSEFWERDSHVEY
>A0A8C2JIM1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MVDAVSPLLDKSVKNQKRSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVIAQGIQC
EVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTY
LKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQAD
FQAWKAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSERMEGD
EEDSQRVKLSKQNGVRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQE
AVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISS
FLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQ
RTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVI
YFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGT
KIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A7K4DC76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosa archaeon|TrEMBL
MENVWSTLKRQKYKIVGANSAVKICHWTKKSLTEGRVCYKQRFYGIESHRCLQMTPSVAW
CSHKCLFCWRPVEYNEEKPSKYDDPETIIEGCIEAQRELLSGYHGFLEKVDINKLKEAEN
PNNVAISLAGEPTLYPEISGLIEGFRKRNFSTFLVTNGTTPEVLSSMDSYPDNLYITLPA
PTKETYEHVCNPQIKNGWEKLNESLELFPKIKTERRILRLTLVKDYNMADIDNYAKLIEK
SKPDFIEAKAYMFVGYSRKRLEIENMPTFEDILEFCKDLEEKSGYKSVDSASDSRVVLLS
RN
>A0A8C2JIY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FLILVKKDPDFSHCTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGM
RYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAW
KAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSD
AESSAEEEKSHGSVIDMEDLGNVMNRMKKTKVKTKPCRSTVSMLRGRGGCYKHTFYGIES
HRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRGVP
GVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLV
PVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDE
LKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIA
CEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWA
IFGARERGFDPSDTRFQRKNKTKNISGC
>A0A0F4YZ64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rasamsonia emersonii CBS 393.64|TrEMBL
MAGDATATGVSWLLTVWHAVRIPLLLALAVIVLVRSYGKSLPRSKTPSSSSIPPSPRLEK
AVWPQDDGAEKQTASIPAVDIEKAPSSNTAKPKTAAAGPKRVVGNRQLKDAAKRRGASDD
LASPSFIKPIIFFASLTGSTERFANSLVEELRAAAQERSKSVQRDRGLLLPEIYDLSYID
FEDYFVSAPKPPPNSPQTRYVYCLLIPTYNIDSIINTFLSHLDETHHDFRIDTAPLSGLA
GYSVFGFGDGEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSNAQDALKEWT
RGLLDVLDEIVETGGLGEGVPGSGDPLESDEEDVAEDGEDNVTGHKDKAEAVVDLEDIKL
NVDSGMSDTKSKSATSNQSSATTPAVKEMVPKSSPTYAALTKQGYTIVGSHSGVKICRWT
KSALRGRGSCYKYSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEM
IFQGVKEGHYKKIKMLRGVPGIRADRFAEAMRIRHCALSLVGEPIFYPHINEFVRLLHSE
QISSFLVCNAQHPDQLAALDRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILR
EKRHVQRTVFRLTLVKGFNIEDEIRGYADLVEKALPCFVEVKGVTYCGTSTSAGAGLTMK
NVPFYEEVAAFVVALNDELQRRGLKYGIAAEHAHSCCILIASERFLVNGRWHTRINYDRF
FELLEREKSKGISFGPEDYMAETEEWALWGNGGFDPNDERVYKKGRNKTVNRQENDSKS
>A0A2A2H514|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium bryantii|TrEMBL
MSLNDENLKKLEKMGYRFVGNNKHSAAKVCHWTKKSILDEGVCYKQKFYGIESHRCLQIS
PSVPFCHQKCLFCWRDLSVTQTQWKGDFDEPGEIIDGCIDAQRNLLCGFFGNEKANPKKL
QESQDPNNAAISLAGEPMLYPKIDDLIEEFHRRNFTTFLVTNGMTPEKLENLKEEPTQLY
VSLDAPNKETYNKLCNPQVENGWNNLNKSLDLISSFDCRTVLRMTCVKGYNMQNVDEYAD
MIKKTNPDFVEIKAYMFVGYSRKRLTFENMPSNQEIYDFASSVAEKCDLEIKDKSYESRV
VLLK
>A0A420NT64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVVLVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A0C3HDV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oidiodendron maius Zn|TrEMBL
MAHDNWSLMALLPLEIFDLVSLWHTYRIPIILTTFTILIILRTALHIRASREKGIASLPP
SPKFSIERKGFLGDTKASEKAPRRIVGGLKKRNSLGENATPEDQKVQVLVFFSSLTGTTE
KTAKLFTEQVIKSQADSAVFHEAQLLDLSYIDYDDYFITPPKDKSSIQYFYIILIPTYNI
DTVLDNFLEHLRETHNDFRIDTAPLARLLGYSVFGFGDREGWPTEEEGFCSQAREVDKWM
AKLTGRKRAFPLGMGDAKTDALERLREWREGVEDVLANIAETGGLGEGVVGSGDAVESDV
EDEDVAEDGGELLFEEQTLARRKTKAQKSGLNDLEDIGGTLNKSTSMSDSSEPLEIDFTT
YSKGAQPPSPAITKEMVPKNSPTYDALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVIDPPELIFEGVKAGHYKKI
KMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINAFTAMLHKERISSFLVCNAQHP
DQLAALNPVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILRERRFEQRTVFRLT
LVKGFNIDDEAEGYADLVQRGLPAFVEVKGVTYCGTTSSAGAGLTMQNVPFYEEVCAFVE
ALNTALARRGLDYGIAAEHAHSCCVLIASTRFKREGKWHTRIDYEKFFELLESGEKFTPE
DYTGPETPEWATWGNGGFDPRDERVHRRGKNKVALTESQGALMKGKD
>A0A3P8TCW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amphiprion percula|TrEMBL
WVRKAEQKNNSSSDRDAEVHVSGVKIFYGSQTGTAKGFANELSEEVNTLGIPAEVIDMKD
YDPDDQLADEVSFKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYA
VFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRNGSVQADFQAWKVK
FVNRLQALARGEKKSCNGNCKTGGSCKNKKKEKQEEEERAAAQNNSSEEELIESSSDEEE
SGPSDEKKSGSVIDMEDLGNIMNSVKKAKVRLHRHFLLNMSVYSYKALFFPRCSLSFCAG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDPAEKILQDAVEKHQSMIRQFRGVPGVKPERYEEGLSVKHCALSLVGEP
IMYPEINAFIRLLHFYRISSFLVTNAQFPQEIRYDLVPVTQLYVSVDASTKDSLKKIDRP
LFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTY
CGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWW
TWIDYERFQELAKAHEESGGQQSFSALDYVAKTPSWALFGAQEQGFDPADTRFQRRNKTK
DISGC
>A0A899FYP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pneumocystis wakefieldiae|TrEMBL
MADDEGDKYLYGEEDDYKPSNGVEVPKNEGNGSPLYGSNVDMEDLPKNREIGSEEEEEVE
SDSDIEFVIETKPGQRAEPLSRPAPYSNVKISAPTKGIDKVFIASSKQEPPSTKPPGVDV
DHVAEWNGKPLYQLDIESLAEKPWRKPGADITDYFNYGFDEFTWMAYCTKQEGIRRDFTP
QKIMQMMEQMPGTDMMSMPPNMQVMMAAGGFPGMQNISGMKPDMVSMMGMGMSDMSGFMM
NMGQMGFQQFPPGLNSMNPEPQLGQNAQGKQMPYSHNLYNMQPYGGYNQMQSQYGSQMQG
VKSTSSTSKGHNADGAKVLPNERVQSSVNYKQDSSLGSSKESHESIESVSNAPQNRSSAR
SNMQNRNKSSSIIPDFMEFCQRIIISLYFLIYIIQLCFDYLDKIDKNFKKNFHYYLGDKL
EVSNMLLLLYQLWKSYRVFIAICLVLVYTLYFFIAYFQQKIPLIDRKSCALSVPSKENHV
ISPEEDKNGFTEISKFVKIRTPKRFVGSSVKHPKPSNISRDARQSLVQNNGQVIVDVNDI
YVSILYQTLLGSTEKYAKILHDILSPHFEKKVLLKNLDFVEDFDDYFVSPDNPESRIFIL
LIPSYETDSPVDLLISTLKDVLHDFRVGAIPLRNLKGYAVLGFGDENEWPGQKFCYQARD
VDQYMSKLGARRIVSLGCGNVKGDIINDIQSWANVLLNGIKNGTMPELIPDVSDESENEP
SEDNEDSVVDMEDMGMLMKTKKKDPRELEPKEMVSKSSPTYKSLVKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKYSFYGIRSHLCMETTPSLACANKCVFYILLGMMEGHYNKIKQMK
GIPGIRSERLEEAMRIRHCALSLVGEPITYPYINELIKMLHDRKISTFLVTNAQHPDALE
SIEHVTQLYVSIDASTKDSLKKIDRPLFKDFWERFISCLEILSRKQQRTVYRLTLVKGFN
TEEVEQYAHLVSIGKPCFIEVKGVTYCGNSNSSSLTMKNVPFHEEVVGFVKALAKKISEV
DNILEYDIACEHVHSCCVLIAQKKFYINGKWYTHINYDRFFELLESNMPFSVMDYISETP
QWAYFNSPYEGFSPDDVRWKRKNAKTVDFKKEEIGLQNNVEY
>A0A1V8UWD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rachicladosporium sp. CCFEE 5018|TrEMBL
MFNQELLLPDELLRFWHAHRVEALIVAGLVLLAVRLALHWRSKRVIAAKIADDTTTAKLA
PTPVITSRDVEDVKHVLPSNAPARPKPGPKRVTGLRKAKPRNVRERTSLVRPIVFYYSLG
GSTRSYATQLAALLSQPKGAVETAPVEVLDLTEIDYDDYFISPPKHTATGRSISYFYLLL
IPSYDIDTELSNFLTHLEETHHDFRIDTAPLSGLAGYSIFGLGDQQEWPTEQDGFCSQAI
EVDKWMAKLTGRKRAFPLGLADMRGSPEVKLEEWAAGVESVAHDLATGTGLGEGVSGSGN
AVESGDEDEDAVLDDTEAKDDREGDVEDIGGRSPIPVDFTTTSRTKPTSPSAPKAMVPVS
SPTYTSLTKQGYSIVGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCS
NKCVFCWRHGTNPVGTTWRWQVDEPELIFDGIKENHYKKIKMMKGVPGVRAERFSEAMQI
RHCALSLVGEPIFYPHINKLLAMLHAEHISSFLVCNAQHPDELAALGPVTQLYVSIDASN
KESLRKIDRPLHRDFWERFQRCLDILHTKRNTHRTVFRLTLVKGFNVNEEAEGYAALVDR
ARPSFVEVKGVTYCGPSTAAGAGLTMQNVPFYEEVCAFVLALEAALKRRGLDYGIGAEHA
HSCCILLADRERYFLPTGPSGERRWHTLIDYAKFFQLLEGGEAFGPEDYIGDATPEWASW
GKGGFDPRDERVDRKGKPKGALEELPSAVMIREAEVTG
>A0A1A8SBM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius rachovii|TrEMBL
MARAVFDHSLAAMLRLLLFLSHITAHVASSDTNAQQEAPRSGESYLLWVWTNRLYVYSAA
ALVFGTWFLLKVTQQEKHTDSAGPSSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIE
ALGITAEVVDMKNYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDF
RYGKSYLKGLRYAVFGLGNSVYVGRYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRH
GNVQADFQAWKVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVDRIES
SSEEDESGLADERTSGSVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGER
REMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYE
EGLEVKHCALSLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVS
VDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELI
TLGQPDFIEVKGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNC
LLIAHTKFKVDGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQG
FDPADTRFQRRNRTKDVSGC
>S7PKJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myotis brandtii|TrEMBL
MIKGVLLGFRYKIRSVYARFPISVIIQENDSLVEIRNFGGEKIHLQNLDEIKYFSSSVTS
DPPLPPNTVKGKSENHRWTIRIMFNINPLENLKLYISSRPPLVVFMISVSAMAIAFLTLG
YFFKIKEIKSPGMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTTTPESTMTSGQARVST
QSPQALEDSGPVNISVAITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINI
TFTLPAAWSSDDCALHSHCEQVVFTACMTLTANPGVFPVTVQPPHCVPDTYSNATLWYKI
FMTARDANTKYAQDYNPFWCYKGAIGKVYHTLNPKLTVIVPDDDRSLINLHLMHTSYFLF
VMVITMFCYAVIKGRPSKLRQSSPEFCPEKIVTRKQDKNSQEKSIPKAAQDLMTNGYISL
HKKEVFVSGVKIFYGSQTGTAKEFATILAEAVTSLYLPVAVINLKEYDPDDNLVEEVTSK
NVCAFLVATYTDGRPTESAEWFCKWLEEASNDFRFGKTYLKGMRYAVFGLGNSAYASHFN
KVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASNDFRFGKTYLKGMRYAVFGLGNSAY
ASHFNKVGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGSIEADFRAWKTKFISQLQVLC
KGEKKSCDGSCKKGKCESNQRSSEEMELGSHTQDGLHQRDPEEEEPFESSSEEESGTEDH
QSLTSVVDVEDLGNIMNHVKKEKREKEQQEEKTGLFRNTVKNEASERRAMITPALREALT
KQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILKEAIENHQNMIKQFKGVPGVKEERFKEGMTVKHCALSLV
GEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKID
RPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGHPDFIEVKGV
TYCGESSASSLTMANVPWHEEVVRFVRELVDLIPDYEIACEHEHSNCLLIAHKKFKIDRE
WWTWIDYNRFQELIQEYEDSGGSKTFSAEDYMAKTPHWALFGANERGFDPKDTRFQRKNK
SKDISGC
>A0A1B6HHE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Homalodisca liturata|TrEMBL
MISIEEIEHFAYEYYPFVIYFSLTIITTSLFLYFHESSQPSKKKDIHNDRSKLIGSKVSG
GPLKKKVYRKRDSKIKPSKIVILYGTVTGNSKVYSLKLQNKLKGLTEVTAIDISGIDPEE
TLFELASVENVVLLLLPTHSEGTPPPTAAWFYKWLGESASDFRYDKTSFKNLHYAVFGLG
NSSYQEHYNVVGTQVDQWLQDLGAQRVLPLALGDEDSLDEDFNKWAKLVAELATAESSSA
SPIDGEEALANGLMDLEELGPALRQMRQQTAITPVVKEMITPTLRQALTKQGYKLLGSHS
GVKMCRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKTDNAEDILSDALSAHYNMIKEFKGVPGVLPERLAEGMQVRHCALSLVGEPIMYPHINT
FVRLLHRQHISSFLVTNAQFPAAIRDLSPVTQLYVSVDASTKSSLKKIDRPLFSDFWERF
LDSLRALSKKGQRTVYRLTLVKAWNVEELESYSQLVLLGKPDFIEIKGVTFCGGGDGNSL
KMENVPWHEEVIEFSKKIAALLPDYALAS
>A0A843L813|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MPQEDQAVQILSRQGYHLVGGGAVKPCLWLNRAMRGGEQCYKHHFYGISSHRCVQMTPTL
ECNHLCLHCWRPIEGQTPAKEPLEPAALLDGILSGQQRFLSGYGGAKTTDPARLAEAWVP
RHVALSLMGEPTLYPYLAELLELISSRGMTSFLVSNGTNPDVLSALRPTQLYLSLNAPDE
DLYHRVCRPSGHFWPRILQSLEVLREHCCRSVVRLTLARGLNLERPEDWARIIAQGEPDF
VEVKAYMHLGRSRNRLAREAMPPHEEILQFSRNLGGALGYEIEADVPLSRVALLSSGRVE
RHIISS
>A0A842UDJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MLTEETKKSLENQQYGIAGRHSAVKTCTWTKKSIRNEGVCYKEQFYDIKAHRCMQITPSL
SCCNRCIFCWRDLSAPTATEWSWKTDSPEEIVQKCLEEHRKLLIGFRGNEKANQEKLKEA
FEPNQVAISLSGEPTFYPKISQLIRLLHRKKMTTFLVTNGQYPDVLERIEPPTQLYISID
APNKELFQKIEQSAHPDAWQRFKRSLDIMKTMNCRTAARITLIKGINMEDMEGYKKLIEK
AMPDYVEVKAYMFVGSSRQRLAIKNMPYHEEVREFSVKLASILPDYSIRDEKAESRVVLL
ARNKKE
>A0A7J3LN86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MDNAIKKLLQKQQYAFTGRHSAVKLCRWTKKAIRGEGHCYKQEFYGIESHRCVQLAPGVT
SCQNRCIFCWRPIEFTDNEIGTPLDQPDEIIDNALAMQKRLLSGFGGTEKTDIQKFKQSK
EPKHFAISLAGEPTLYPKLNELISAVHRRGMTSFVVTNGMLPERLEGIEPPTQLYLSVDA
PNESLFKKIDQPTLEDGWKRLIQSLDAVKKLKSKTRTTLRLTLIKGMNMVHPEQWAELIM
KAEPMFVEVKAYMFVGFSRQRLLMENMPLHNEVRDFAMEISKHCPYTLVMEKKESRVVLM
MREGMEYRLLNKIMQEKK
>A0A832TBV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MVKESYRKLLEKQHYAMIGSHSAVKLCTWTKKSLRDEGVCYKEKFYGIKSHRCCQMSVTI
NYCDMDCVYCWREHYNEPFTDIDDPEELVKKAVEAQRKLISGFGGFEGTNKDKLKEAQHP
DQFAISLTGETLYYPRLSEFIRELKQAGNSTFIVTNGMLPDILEKLEPPTQLYISIDAPN
ADLQKKLCSPKHPDAWDRLTRSLRILSQLRSKTRTALRLTVIKGMNDIDPEGYARLIKLA
DPHFVEVKAYMFVGASQLRLSMKDMPFHPEVKAFAEKVAHNAGMKIIDEQEESRVVLLMK
EDFPERIMR
>A0A662EZJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MISEAKKKDLEKQGYRIVGNHSAIKLCLWCKKAIRNEDTCYKNTFYGIKSHRCIQMTPSL
QTCSHRCYFCWRDIDWTKAKWEGPVDSPEEIVDGCIREHIKYIQGFKGTMDTTDAKKFKE
ALEPLHFAISLSGEPCSYPELPKLIDEIKRRKMTAFLVTNGTIPDMIKKLAKKHEPTQLY
ITLPAPDEKTYKKVCSPMIRDGWLRIMESLASLKDFECNTVIRLTLVKGINMFNPAGYAA
IIKKYQPVYVEAKAYVWVGHSRERLGIESMPQHQEIKSFAEDLSELSDYKIVNEKKESRV
LLLKR
>A0A7K7NF14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haliaeetus albicilla|TrEMBL
LDVSMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKSNGNP
ASFEGIEDKVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVIALNLPVEVIS
MGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVNDFRFGKTYLKGL
RYAVFGLGNSVYVDHYNTVGRNIDKWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAW
KAKFLSQLQALCRGEKKPCSGKCKKGKCKSLGKQSKESSDHEHGASEYENTEAEELFETS
SDEEADGEEAGGTNSVIDVEDLGSIMSHMKKAKVLHFGLSHIVTLVALSLRNEKFSFSDE
LHCPFSHFFLSWNGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSL
ACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEA
MTVKHCALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVD
ASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISL
GEPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLL
IAHKKFKINGEWWTWINYDRFQELVREHERSSGSKTFTAADYAARTPRWALFGSRERGFD
PLDVRYQRKNKARDISGC
>A0A2K0U336|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma harzianum|TrEMBL
MDAASRLQLEAMVADLVEVWHLHRTTIILASLFLLAGLRIFLHTTEKREPLAALPKIYNQ
EQPKAIEKPIVKAPPVVETEKKSTGPRRIKGGLTRKYSQEGKTATNEYTDRPAKVLVFFS
SVTTKTEKIARDYIDALETFLDQKAKETDGKFLKPELLDLTEVDFEDYFVSPPKSTEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAALSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHAERFAEWTSGVQDVIAQAAQTGFLGEG
VPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDVEDLGKMLRPNKDGNEG
TRKAPLAVDFTTYTSANKKKAQAPIIKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDL
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALDKRLQEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQKF
FELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>A0A0E3NF81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina thermophila CHTI-55|TrEMBL
MRKMPMEEKKRNTGEDFPEVQEKNGGGESTSLPFDIPDFKTLLKKQGYALAGRHSAVKTC
LWLRHAMNGQGSCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDLPE
KIVEESIACQRKLITGYGGSPNALKERWLEGNEPNNVAISLSGEPTLYPYLPELIEEYEK
RGFTTFLVTNGTVPDMFAKISPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSIMK
QKKSRTVIRTTLVKGENMFKPEAYARLIEKASPDFVEVKAYMHLGFSRLRLDRSAMPTHE
EVLEFSKELAKHLGYKIADESEISRVVLLSKDGNKSPVRNLSFPD
>A0A7J4I5C9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MVPTKAIHATQQATQVLSELQHKAEQLRHEMITQELLVDNDFAEDREELNALQETQEERT
GKNREKVVEENAEPVFSDKLKDRLRKQQYRIIGSHSAVKTCGWTKSSLTGKGGCYKQKFY
GIQSHQCVQMTTYLTCANFCTFCWRDMTAKAHNEFKGTPDDPKMILDNAVEGQKKLLIGY
KGHQHIDKQKYEESQFPKHFAISLTGEPILYPRLQEMITYAHSKDSTTFVVCSGQFPEQM
DAITPTQLYLSLDAPTKNLFIKIDKSINKDSWERLLGSLDALKRARERCRTVVRITCVKE
QNMVDPQEYAKLIERANPMFLEVKGYMFVGSSRQRLSLKNSPFHEDVKAFAEEIARYCDY
KVIDESACSRVVLMMKEDVAERFLER
>A0A432Q790|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus sp|TrEMBL
MEKHTKGNYEPPKKFLQDLKGYKIVGGHSAVKLCLWLKRSLRDRGVCYKQKFYGINSHRC
LQMTPALMCNQSCIYCWRPLDLLPGVKGWDSADFVAEECIKAQKVLLSGFGGLSDVNRRK
LEEAKKPNQVAISLIGEPTLYPYLDELVDIFNSKGMTTFVVTNGTKPEMVEKIDPYQLYV
SLTAYSEESHAIINRPAKNYWNEILKSLKILANKDCRTVIRLTLIKGLNMIPENFVELLD
MASPDFIEAKAYMHLGYSRMRLERSAMPSHDEVRAFAEELERLTGYEIKNESKISRVTLL
TK
>A0A219AMX7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp. 87.7|TrEMBL
MALTREEQKILEKSGYRFLGKNGHAACKICHWTRESIVNRDVCYKQKFYGIESHRCLQMS
PAVPFCQQKCSFCWRDLSLTKTEWEGPWDDPETIIEDGIREHNKLLCGYYGNDKADKKKL
EEMKKPTNAAISLAGEPTLYPDIDGLIGEFNHQGFSTFLVSNGQNYEKLNSLENEPSQTY
LSLDAPNSKIYKNLCNPQIDDAWDNLNKSLEILNTFTNNTALRITVVKGKNMINPEDYAK
LIEKADPTYIEVKSYMCVGSSRDRLSLDNMPTYDEVNKFASEIGENCGRSITNGSEISRV
VLLTKD
>A0A364L099|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces amestolkiae|TrEMBL
MADSSFVPGFLATWHSFRVPIIVSLAVFFIFVRFFGTKRSKSPLSSSLPPSPRLESAIPK
EKPVAPILDQKSVTEVKSTPKSVAPGPKRVVGNKGRRGGKDTQKAGELNGPSYIKPVIFF
ASLTASTQTHARWLSEELRTAAQEKSPGKDEEWGLLPPEIYDLAEVDFDDHFVTAPKPPA
NSPNTRYVYCFLIPTYNIDTIIDTFIAHLDETHNDFRIDTAPLSSLAGYSVFGFGDKEGW
PSEEEGFCSQAKEIDRWMAKLTAKRRAYPLGMGDTKTDALDCLKDWTNGLADILLEVAQT
GGLGEGVAGSGDPLESDEESAAEDEDESSNKKTQTVVDLEDINFGARAKKSKGDPIPVDF
TTVSKVQTSPTTLKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGTTWRWKVDPPEMIFNGVKEGHYKKIKMLKGIPGVRAERFAEAMRIRHCALSLVGEP
IFYPHINEFLGMLHNEQISSFLVCNAQHPDQLATLHRVTQLYVSIDASNRESLRRIDRPL
HRDFWERFQRCLDILREKRHVQRTVFRLTLVKGFNIDDEVKEYADLVEKGLPCFIEVKGV
TYCGTSSSAGVGLTMKNVPFYEEVVAFVLALNDELERRGLGYGIGAEHAHSCCILLASDR
FKVDGKWHTRIDYDRFFELLEKEKSEGISFRPEDYMRETEEWALWGNGGFDPNDQRVRKV
RNKKPKNDQSAE
>A0A8H3N684|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus lentulus|TrEMBL
MAEHSTAEGLLAFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSLESSNKATTQKAERQPAVANGSARTTSGPKRVTGKKPLKVAGRRGLTEDAEPL
AFIQPIIFYASLTGNTERYAKILLEELRAAAQKRADLQDRERGLLPPQIHDLSYVDLDDY
FTSAPKPPSNSPGTGYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGFGDVKSDAESSLKEWSQGLQ
DVLFDILKNGGLGEGVPGSGDPVESDEELDDEDADKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSGQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHAEHISSFLVC
NAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEKEK
ADGSSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A2U3WAR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Odobenus rosmarus divergens|TrEMBL
MDPLDTWDFSSSLMSLWINRFYVYLGFAFGISLWICFQIVIRKQLFIFKDKNSQKSVPKA
TGDLMKNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKEYD
PDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVF
GLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTKFL
ARLQTLQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGKI
MNYVKKEKRENEQQEEKSSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHCCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMD
QPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLKL
LHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALATKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMAN
VPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQELVQ
EYEDSGGSATFSAKDYVAKTPHWALFGARERGFDPKDTRHQRKNKSKHISGC
>A0A7J4QL36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDPTLKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLTGFGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYTRLAEYMDLCHQHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQIFDDVCRPKWNSGAWEQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAALDR
RADPDWIEAKGYVYVGHSREHLSIDNMPSHEDILAFSESLAPQVDMRILSESRPSRVALI
GNEMVPIPIPEASMHFPEDLGIASPVKKLKLADLS
>A0A319AUG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus saccharolyticus JOP 1030-1|TrEMBL
MAELSVAEGLLAFWHLYRLPLLLTLVAAFTFIRVYRTLQPKSRIATASSVPPSPRSHSPE
KSEKIAVGYDEKDVPAAGSNTKTIVQKETSAKPTSGPKRVSGKKPLKVAGRRAGSDQEQP
LSFIQPIIFFASLTGTTEKHAQDLLEYMRIGAQERADLENRERGILPPQIHDLSYVDYDD
YFAAAPKPPPNSPGTRYVYCLLIPSYNIDTVLNTFLSHLDETHNDFRIDTAPLSSLAGYC
VFGFGDKEGWPTEEEGYCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAEAALREWAHGL
QDILGDILENGGLGEGVPGSGDPLESDEEDLDEEEESDGNRKINRKRNKTQDVVDLEDIK
FSADSQNGSGAPVPVDFTTAGASAPSAIQPSEKEMVPKTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWK
VDSPDLIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFL
DMLHSEHISSFLVCNAQHPDQLETLSRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLDILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAG
AGLTMQNVPFYEEIQEFVTSLNQELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSR
INYQRFFELLEKEKADGTPFKPEDYMEETLEWALWGNGGFDPNDERVYKKGKKKGLQAAA
ATLD
>A0A524MIG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPTELREKLENQGYHLLGKRGAFKACQWQKKALLYGDACYKQRFYGIESHRCVQMTPIVD
KCTHNCDFCWRITPSDVGISWDQVKVSKDDVVPVNELMDAVLMANLRSLGGYNPDAGAKV
LREKYLEAREPKHVAVSLAGEPTLHPQISELIEEIHSRKMTSSLVTNGTRPDVLERMTAP
TQLYVTLAAPDETTYKKLCKPGIKNGWQKIVESQEMLHSLNTRTVNRLTMVSGLNMKNPR
SYSDLIHKGRPDFVEVKGYMFLGSSRGRLSNENAPSHRDIRAFSQKIADLTGYYLLDEQI
ESRVVLLSQSKHIKKLQ
>G2WQ92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)|TrEMBL
MSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQVTGEKPEQLKALPKKL
AADETVAEKAALARDAKAEKPPVVVAEASGAPRAPKTTSGPRRVKGGVVRRRSSDDNVDQ
PPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHKAAPETRCTFEAPELLDLAEVDFDDY
FVTPPPAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSVFGF
GDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIIEIL
GQLARTGGLGEGMPGSGAPVESDEEDADEEDDDETLVEDGEAKPEKLKNSKNLEDVEDLG
RIMKDSRPDSVPAKGKGAPIAVDFTTYGKTAAKKAAPAPPTVKEMVPRNSPTYASLTKQG
YTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGEP
IFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRPL
HRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDDEVDGYAALVERGLPCFIEVKGV
TYCGTSTASNAGLSMSNVPWYWEVCDFVKKLEARLADKGLRYGIAAEHAHSCCILLASDR
FRVDGKWHTTIDYQRFFELLEERGPDGDWRAEDYMGPATPEWATWGNGGFDPRDDRVDRK
GRKIEAK
>A0A7J4F936|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDESVGRILRRQGYALMGDHAAVKLCHWLRESLVRGRPCYKEVFYGIESHRCLQMTPWLG
CNQECRFCWRYPGWGGSPNLVDPHTMLDRAIDAQRALVSGYRGVPTVDDARWQESRVPNQ
MAISLSGEPTLYPYLGGLIAAADERGITTFLVTNGTRSDVLADLDPLPTQLYISVDAPSE
EVYRQLCRPTTGSLWSRLIESLDTLNGLDTRTVVRHTLVRGWNMEDVEGYARLVRRADPD
FVEAKGYVFVGHSRLTMSIDAMPSHEEVLQFSRALARATGYEVTAERPDSRVVLLTKDGR
LPREYRPIGPVK
>D9PXR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)|TrEMBL
MYAEKSQRRMERMGYRFVGENRHSAVKTCLWTKKSIINEGFCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTETAWNGPHDEPADIIEGAIEAQRKLLCGYFGNERADKIKVL
EAQDPTNAAISLAGEPLLYPDMDGLLAEFHKRNFTTFLVTNGLASSNLEALSVEPTQLYI
SLDAPDRETYEKLCRPQIPDAWDLLNRSLEIMPSFNCRKVLRITAVRDINMKKPEMFARM
IERAQPDFVEVKAYMYIGYSRKRLEIDNMPLFYEVHEFADSIADSCGMEIVDESRESRVV
LLA
>A0A852B158|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chloropsis cyanopogon|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTITRTKRKVTEPGTLDKLG
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPEAVLA
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKNFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQLQVL
CKGEKKPCSGKCKKGKCKSSGKQSKESLDHEHGTSEHDNTEAEELFETSSEEEAGSTDSV
IDVEDLGNVMGHMEKAKVLLLEGVWIHGVSHSGHHLVYFVCQFLQAKLNCLMICALFSGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKEARLEEALAVKHCALSLVGEPI
MYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLF
KDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCG
ESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTW
IDYSRFQELVREHEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDI
SGC
>A0A662JYG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNEELRRILRKQRYAVIGRHSGVKLCHWMRQSLLYGRECYKQSFYGIESHRCLQMTPSLN
YCTQSCLFCWRYQGFTETFFKDEVDDPEYILEESIQAQRRLITGFKGDVRCDHRKWMEAN
NPNMVACSLSGEPTLYPRLGEFFDVCHRRGMITFLVTNGTTPEVLENLDPLPTQLYVSVV
APDREVYKRLCVPLVSNGWEKLIQTLELLPSLDTRVVIRHTLVDGWNMDDKYVEKYAKLD
EKASPLFVEPKAYVFVGYSRRRMSISNMPSHSSVKSFGEKLSALLGYEMVMERSDSRVVL
LASDPKKRKIR
>A0A843IAU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MNPELQKILARQRYAVVGNHSGVKLCHWMKQSLLFGRQCYKQAFYGINSHQCLQMTPTVT
HCTHMCLFCWRFQNFTENQLLDPDDPGFILEQAIVAQRKLLTGFKGDPRCDQKKWNEANH
PNMLACSLSGEPTLYPRLGEFFEACHQKGITTFLVTNGTMPEALERMSTLPTQLFVSLVA
PNEEVYKKICAPLIPNGWEKIQKTLELLPSLSTKTVIRHTLVHGWNMDDEHIKEYAKLDG
KAQPTFIEPKGYVFVGSSRNRLHFSNMPRHEQIRSFSQRLSEEIGYSQVAEKEDSLVVLL
SAKNQKKKKE
>A0A3Q0E1U4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Carlito syrichta|TrEMBL
MDPLAAWDLSSPLISLWINRFYIYLGIAFGISLWICVQIVMKKQDRNSQKKSVPKATQHL
MTNGYIALQKKEIFVSGVKIFYGSQTGTAKKFAAILADAVTSLDLPVAIINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLRGMRYAVFGLGN
SAYESHFNKVGKNVDKWLWMLGAHRVLTRGEGDSDVVKSKHGSIEADFRTWKTKFISQLQ
ALQKGEKKKSCGGNCKKGKCESNQHGSEEMEPGSHAQDELHHRGTEEEEACESTSEEEFG
SEDHKSLNSVVDVEDLGKIMDRVKKGKREKEQQEDNTGLFRNSGRNEDGERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIGNHQNMIKQFKGVPGVKVERFEEGMKVKHCA
LSLVGEPIMYPEINRFLKLLHQHKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVRELVNLIPNYEIACEHEHSNCLLIAHKKVR
ITQPFVLQTPYPTAPFFSFLLLSP
>F0NQY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain HVE10/4)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A0T5ZH62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon CSP1-1|TrEMBL
MSCSGEIQSSDDELIQIKPKIVQQLKKAKYGVSDHSTVELCHWTRKSFKNEGDCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPENVAESEQVVSKLMEERRKLIM
GHYGDSRYEKQKLDESLLPAHYAISLSGEPTMYPKLPNLIKYLKSLPETKSIFLVTNGQE
PDMLQKLKDEDALPTQLYLSTNAADYKSFLKINRPRYEDSWERWKTSLRMLSKLNTRTVL
RITLIRNYNDGDEMIPAFASMLRNSSPNFVEIKSYMHIGRSTNRLEHDNMLDMDEVRHFA
SKLSEQSEIFSVMDESFISKIVVLQNQERFIDRLIPTYTQTN
>G4N597|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)|TrEMBL
MSHPLGTTSSLGNLPSLAVEIWHTYRIQVILSVVAALILLRFYLEHTQGRDKSSVAFANK
FGEENVKDGPSPPPVETQKKSTSLEKTKPSGPRRIKGDVNKTGKNGGAQADITATGREIL
PLVFFSCVTGRTDKVAREYAARLDESLRALPAVAGCSFRESRILDLSEIDYDEYFISVPK
IEAQKEGSRVELLYLLLLPSFNIDTINDTFLEHLQETHHDFRIDTAPLAAILGYSVFGFG
DREGWPTEEEGFCFQAKEVDRWMAKLTARKRACPLGMGDSKTDAPERLSEWHDGVVDVLS
LLARTGSLGEGVPGSGDAVESEDEGGSNEDDDEVLIEENGWTEKKPKKSKSKALDDVEDI
GRMLDTSRANGTAPPVAVDFTTYDKPKGGSRKQPAVQTVKQMVPKSSPTYTALTKQGYAI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMEATPSLSCSNKCVFCWRHGTNPV
GTTWRWVADPPDMIFDGIRSGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINEFLQLLHAEHISSFLVCNAQHPDQLAALGHVTQLYVSIDASNKDSLRRIDRPLHRD
FWERLQRCLDILREKRFRQRTVFRLTLVKGFNVEDEVEGYADMVEKAMPCFVEVKGVTYC
GTSTSAGAGLSMSNVPFYHEVTEFVTALEKSLRKRGLAYGLAAEHAHSCCVLLASERFLV
DGKWHTRIDYEKFFQLLEQKGPHGDFSPEDYMGPETPEWATWGNGGFDPRDQRVDRKGRP
IEA
>A0A1D2WUX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp. A54|TrEMBL
MSLNKKQVEKLESSGYRFVGSHNHAAAKICHWTKQSILDKGVCYKEKFYGIESHRCLQMA
PAVPNCQQKCEFCWRDLSYTQTQWEGEYDDPKTIIDEAVKAQNNLLCGFFGNDKANKEKL
EESKTPTNAAISLAGEPMLYPEIDELIAEFNRRNFTTFVVSNGQCVDKLKNLENEPYQLY
LSLDAPTKKIYNDVCRPQISEGWDNLNQSLDTLASFNSRTCIRTTCVKGRNMTNPEKYAE
LIKKASPDFVEIKAYMCVGSSRHRLTPDNMPTFDEVKSFAQKIGENCGKKIVNESEVSRV
VLLQ
>V4M5I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured Acidilobus sp. JCHS|TrEMBL
MEVRAEEDVYRLLDQRLIKQGYHLVGRHSSVKKCYWNHAALVEGRFCYKGKFYGIESHRC
IQLSVTNHWCWNACLHCWRLRPQDVGIQWNETRMPFADDPRSIVEGAIREYRRIVSGYKG
RPGVDPKMYQEATNPKHVAISLTGEATLYPMLGELIKEFHRRGITTFLVTRGVRPDVLAN
LEEEPTQIYVSLEAWDKESYNYFNRPLVPRAWELTLETLQLLPSFSSTTVYRITIVKDFN
DNDAALRGFAELVKLGMPDYIEVKAYMYVGASRNRLRLENMPRHEEVKAIARKLSELTGY
PVVSESAPSRVVLLSRLERPIRYGNAPVDWNSPDIPAPGEYEEPNEAATA
>A0A0L8FXJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Octopus bimaculoides|TrEMBL
MLEELLQYEVSEYLHLPVWLLLLAIISFTYLSRFWMKQTKTKVAEVKESVEKTISKDCKT
EVKEWKRSLHILYGSQTGHSKTLAESLAQNAEQQGVQVEVLNIKDCDPEDHIKQFKSPDR
IYVIVISTYVQGSPPDDAVWFYKWLKETAVDFRVQKNFLEGMIYAVFSHGNSEYKENFSV
VGKNIDDWLHQLEANRILPVGIGDEDTTQSSHGGLTEDFNAWNRKFWKKSIPLLKGGTLP
VESNKCCKETCEKKCCDKDNSSSNQEVLMETSSEEEEEDGDNVESSGSLPVTQSNGLVDL
EDLGKVMKNVKKTKTKLKLNGYIVSTNKQTKNEEPKPMITEIFKKSLEKQGYSLIGTHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRW
LMDDPEYIFNGAIANHTKMIKQFRGVPGVLPERFNEGMSPKHCALSLVGEPIMYPEINKF
IDLLHNKGISTFLVTNAQFPDAIHNLIPVTQLYVSVDASNKESLKKIDRPLFRDFWQRFL
DSLQALAEKKQRTVYRLTLVKGWNTDEIEAYADLVDYGKPDFIEVKGVTYCGESKASTLT
MKNVPWHEEVCGFVQQLADLLPDYEIACEHEHSNCLLVANKKFKVNGEWWTWIDYEKFHE
LVQNRKNNSEMIFTAEDYMAKTPDWAVYGAKEHGFDPSDKRFFRKKQKDISGC
>A0A533VLA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGETIEVSSEFLQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFKNDGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLMEERRKLIM
GHYGDARSDKKKLDESLFPSHYAVSLSGEPTMYPQLPELIKYLKKLPTTKSVFLVTNGQE
PDMLQRLQDEDALPTQLYLSTNAPNEEIFQLVNRPKFKDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCDDKLIPEYAKMLKRSNVHFIEAKSYMHIGRSINRLERSDMLEMSEVRHFA
STLAMQTEIFSAMDESEISRIVVLQNQRRFIDRWIAAYANTN
>A0A843M4H5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum sp|TrEMBL
MHSVQCDQSKKALRGMGYQFFHPDSSAALKPCLWCKRSLSGGDQCYKNQFYGITSHRCVQ
LTPTLRCNHTCLFCWRSFEHEYTGEKDLLPQEIVSRIPFLQKKALGGYKVSPKVTKEKWE
EALQPDQYAISLAGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPDVLKRCHPCQKYISL
TAPDRETYLRIARPREDYWDQVLESISYLGHETDAGDRTAIRVTLVRGINDQDPEGYAQI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHDEIEHFTKRMLPHLSYRVLGENTLSRVI
CLERVS
>A0A7C4WGL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSAIPMYRPSRDEVKALEKFKKAGYRIVGRHSAVKICHWTKTALRGGKFCYKRWYGIRSH
RCIQMTPTLQYCNMMCIFCWRFHSINRVSPYGGDWDEPKTILDGCIAAQKELLSGFKGNP
RVTIQRFNEAMDPKHIAISLDGEPTLYPYLSDLIKEAKVRGMTTFLVTNGTMPEVLKELE
TLPTNLYISLYGPDEETHKQITRPLITDSWQRTIKSLELMSSLNCRKVVRLTLVKNYTMK
DAEKYADLIKLAMPEFVECKAYMHVGESQKRLPREAMPNMEEVSAFAKELKDFLGYVLVT
EDSDSRVVLLARSDVELSKIASF
>A0A7C5YCJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MLMQVLRDSYTECIERLKSQKYHLIGAHSAVKKCLWVHNALVYGRFCYKCRFYGIASHRC
IQMSPSVLWCWNNCLHCWRVRPQDLGLSSEELTTLPHVDDPEFIAEMAILEHRRIVSGYR
KRTSEEMFKEALNPKHVAISLTGEPTLYPRLSELIEEFHRRGLTTFLVSRGVRPDVLASL
DEEPSQLYISIEAYDRETYNYFNRPLIPNAWELTLKTLEILPSFTSPTVIRITLVKGFNM
SYEVIKKFKKLLELAQPTYIETKAYMHVGGSVGRLGRENMPTFNEVVEFAKRLSDEVGYR
VVSYSRASRVVLLTRLTKPIRLGGGCPKGWEEVDTCEEEIGEYSRVEEAV
>A0A4W2DSE6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos indicus x Bos taurus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALRKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHQSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKVL
LVMEAWHAAIHGVAKSRTQLSN
>A0A6J1AD52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Herrania umbratica|TrEMBL
MSPSSLSARLTLLALVSATTFYFLYKSRRRLKPLRQLPINPDPRKGKLFFITQTGTSKAL
AQRLLNLLSSNNIPFDLVDPQNYEPEDLPKESLILIIASTWEDGNPPQGSKFFVNWLAEI
STDFRAGNLLLSNCKFAVFGVGSRVYGETFNAVARDLGKRLRGLGATEMVAVGEGDVDGG
ALESVFKEWSEKVVRVLKGGLAVENENGIVYESDAESLESDGDDDGGGREEEIVDLEDIA
GKGPSRKKAVNAAETNAKMDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLRG
RGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAI
DLHTKMIKQMKGVPGVTQERLTEGLTPQHCALSLVGEPIMYPEINMLVDELHQRRISTFL
VTNAQFPDKIKMLMPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALRDKQQRT
VYRLTLVKGWNTEDVDAYSKLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKAF
SEALALKSEGEYEVACEHAHSCCVLLAKTDKFKVNGQWYTWIDYEKFHDLVASGEPFDSA
DYMALTPSWAVYGAEEGGFDPDQSRYRKERHHKSNR
>A0A6V8EWC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPIELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A0A9WXI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lygus hesperus|TrEMBL
MMLEFLLSINFLGHFLIASVIALLIFKNFCNLYSAETSEPILPTAKRQQKENERQRPQSL
YRNIDTNFRCIEVYFATEYGNTKKLCEKLVEYFTTTKSIDSVLIDLSNIEPEDVLHSKNA
QRKCLSLFVLPTVTDGQPPKAAKWFCKWLSDAATDFRIDKQSQAHVSYAVFGLGNSVYAE
NFNIVAKEVDENLAQLGACRVCKLTLGDEDTSESQNGGLEADFDAWTKVIENVVWSQCTP
PYEVLDTRANEVETSSEEEDVVDIEDLVKPKSKRTNSKSEGAKEMITPQLRGVLTKQGYK
LIGSHSGVKLCRWTKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNP
VGTEWKWKMDDANTILRGALENHYNMIKEFKGVPGVLPEKFAEALAVKHCALSLVGEPIM
YPEINKFCRLLHEEGISTFLVTNAQFPEAIRAMDPVTQLYVSVDASTKESLKKIDRPLFK
DFWERFIDSLKALSEKGQRTVYRLTLVKAWNIDEMQNYASLVALGKPDFIEVKGVTYCGG
DSSKPNSLTMANVPWHEEVTSFVEQLIDLLPDYALASEHEHSNCLLIAHRKFFMDGKWRT
WIDYTKFHNLMRYHYETKGESSFSAMDYVADTPSWATFGSVERGFDPSEKRWHRKNGTKD
ISGC
>A0A7L4QDL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon|TrEMBL
MNEGLKKILEKQQYRVYGDHAAVKLCHWMRQSLLHERSCYKQDFYGIRSHRCLQMTPVIT
KCNQRCLFCWRVQGFESEGGDWTDPEEMLDALIEHQRTLVSGFKGDARCPLEKFEEANEP
KHVAISLAGEPTLYPRLGELLEVCHRRGLTTFLVTNGTLPEVLENLDPLPRQLYVTVAAP
NEDIYRKLCVPLVPDGWERLNRTLEIMPSLNARTVIRHTLVKGWNLGWEEQYAILDEKAE
PTFVEPKGFVLVGGSRSRLNLTNMPSHANIVEFSRRLGTLLGIEILKQKADSRVVLLGKS
GTRTEIED
>A0A8C6CNY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Moschus moschiferus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASQD
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPVAMINLKDYDPDD
RLVEEVTSKNVCAFLVATYTDGQPSESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALCKGERKRCRGNCKKGKCETNQRSSEAAEPESHVQEELHHRDAEEEEPFGSTSEEESD
AEDHQSQNSVVDVEDLGKIMDHVKKEKREKEQQEGETSVTRSTVKSEASERRTMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPVEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVGLIPDYEVACEHEHSNCLLIAHKKFK
IGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>A0A7C4E356|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldiarchaeum subterraneum|TrEMBL
MVPLSEVEKPRRSGVKGVEKFSNAGYRIVGRHSAVKVCHWTKSALKGGKMCYKSWYGIAS
HRCIQMTPSVQYCNMMCVFCWRFHTLNRVQPYDGEWDRPEEILERMIAEQRQLLSGFGGN
PNVSRERFSEAMEPKHIAISLDGEPTLYPYLAEFIQLASSRGMTTFLVTNGTMPERLEEL
LEKAQPTSLYISLYGPDKETHVKTCKPLIKDSWERLLKSLEMMGRFSCRKIIRLTLVKDV
NMHSPEKYGALIRVASPDFVECKGYTHVGESQLRLKRENMPSLEEINKFAAELAASIGFI
KVAEDEVSRVVLLANPSSPYYLEAAKQGSSA
>A0A7K4N8F1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSAETVEEDDRLLQIKPAIAKQLKKAKYGIADHATVALCHWTKKSFKHEGNCYKHKFY
GISTHGCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPKQVAEPEAILTKLMIERKELIN
GYYGDSRNDKQRLDESLLPSHYSISLSGEPTMYPKLPELIKYLHSLKATKSTFLVTNGQE
PDMIQRLQDEEALPTQLYLSTNAADYESFKRINQPKYDDSWERWNRTLAMLKHLNTRTVL
RITLIRGYNDIKEMIPAFAEMVRKASPHFIEIKSYMHIGRSTNRLEHTNMLEMEEIKNFS
EQVAKQSKIFSIMDESFVSRISVLQNNERLIDRYIPTCVNTN
>A0A1A8YXX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium ovale wallikeri|TrEMBL
MMEEKRLEHYPSLRSFQMFSIRKRAKINLKVIYGSESGGTYKKAKEFLNELVEFFREIGS
FFKDINRISLCGDNTDGESTNGYLIDTSELGSRLVAYFKSYLVEKEKNKTGLSMESRGKR
SSGGRTNGETQYLDIFKNGRTISNEGFSNCVDILIENSISTVHVDFTSGNEFDSYSFFEN
SQEYDLNILLLLLSTCNYGSFPKNCYKIEEILRDLLNDFRVGKNYLENVFYSCVGFGNKE
YGSKYFCVPIKECDKILTSLGAHKLYKTVKLCDEEDNDVTLLEWKSSLFKTLSLSLFFYH
FDFTKLRSNYVQYAMKKVYNSLKYYCSFFREKDERDSISNGEEVLSEVDAPFREEVDGAI
SPNVHLDENKKETIPTSDTDEIGSRRGETHNCGSGDEVEDILIDTPKDMLTMNQREKLTK
EGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMETTPSLACANKCVFCWRH
HKNPVGTQWKWHKDDANMIVDEAIKKHRGMIKELKGVYGIITERFENAMNVKHCALSLVG
EPIMYPDINQLIDELHKRNISTFLVTNAQFPSELKKLHKVTQLYISIDGPNRDALKNIDR
PLFKDFWERYIKCIKILKKRKERTVFRFTLVKEYNMMCDEILSYAKLVEYGFPDFIEIKA
VTYCGSSEGYKLTMKNIPWHEEVFNFAHHLINCKSSITDAYDIACEHKHSCSILIAKKIF
KINNKWHTWINYENFQLLVKQGKDFTSTDYCAETPHWAVLGAQECGFNPSDKRVYTKGRN
KNRNPDETQGGSPVVVAPTYVAPT
>A0A7J4KP35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MDEILKKLLTKQQYRVIGNSGAVKLCTWTKKSIWDQGVCYKEKFYGIKSYACCQMTPDAN
FCQNKCIFCWRNLEGTEGKMDNKDIDDPLLIIDGSIKSHAKLLNGYPGNSKTNMKKWKDA
QEPKHFAISLAGEPTLYPKLAELIKELHKRKKSTFLVTNGLVPERLLELEKENALPTQLY
VSIDAPNKELFFKIDRSSIKDGWERLMQTLDILRKLKKKTRTSIRITLIKDMNMINPEQY
AQLIKKSDALFVEVKAYMHVGSSRERLTIKHMPLHNEVKEFALEIGKHCGYKLIDEQQAS
RVVLLMKKDFPGRIMKF
>D2RY92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / JCM 9101 / NCIMB 13204 / VKM B-1734 / 4k)|TrEMBL
MSNSAESGVEGGSDTDAEHDESEDGGAMQVSSPDYHSENHTAAQTCGWTANAVRGEGKCY
KYIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHTYEMDDVEWDDPEAVVDASIRLQKK
LLSGFGGNDEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFRDRDITTFLVSNGT
RPEVLRECDPTQLYVSVDAPERHTFDQVVGATEDDAWERLLETMDVLAEKDETRTVLRTT
LVKGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSAMPDHEEVMAFADEVKE
YMPEFTESRGVSESRVALLAKQKDTWVPKLKKGSEFWERDPVVGD
>A0A834LJA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhododendron simsii|TrEMBL
MTTMPSPSAAAHLTLLALLSATTFYCFYKSRRLKNLPRNPNPNSPPKGKLFYLSQTNTSK
NLAHRLLDLLSSNDLPFDLVDLHNYEPEDLHKETLVLIVASTWEDGKPPPNGKFFADWLA
ESAEDFRVGSLLLSKCRFAVFGVGSLSYGENFNAVGKEFSKQMRALGAEEVLPLWEGDVD
GGDLDEVFGAWSEKLVRVLNGGGLGNEAFGVGYGAKDESQYEMISDSDEEDGGENGGESG
VVDLEDIAGKAPSRKSTTIVKSNGKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVKLCRW
TKAQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPL
VIVNSAIELHTKMIRQMKGVPGVKPERLMEGLSPRHCALSLVGEPIMYPEINSLVDELHR
RRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFLDSLKAL
KEKHQRTVYRLTLVNGWNTEDLDAYSSLFGIGNPDFVEIKGVTYCGSSATSKLTMENVPW
HSDVKAFSEALAQKSKGEYEVACEHVHSCCVLLANASKFKIDGQWFTWIDYEKFHNLVAS
GRPFDSKDYMVATPSWAVYGAEEGGFDPGQARYKKERHHKSSH
>H0VIL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cavia porcellus|TrEMBL
MDPPFDVWNLSSSLLSLWINRFYIYLGIAFGISLWICFQVAIKKQAKNSQEKSVPKATQD
LTTNGYLSLQKKQIFVSGVKIFYGSQTGTAKGFAAILGKAVSSLDLPVEVINLKDFDPDD
HLIEEISSQNICAFLVATYTDGRPPESAEWFCRWLEDAASDFRFGRNYLKGVRYAVFGLG
NSAYQSHFNKVGKRVDKWLWMLGARRVLARGEGDCDVVRSKHGSIEADFMAWKAKFIARL
QVLRKGEDKSCGGHCKRGKCDSRLQDSEEQEQEQEPEPEPGPACRDGPWPADTQEEEACE
SSGEEELGPGDHPSLNAVVDVEDLGKIMNHVKKEKREKDRQEEKTGLSRNPGESDGGEGR
AMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVQAARLEE
GMKVKHCALSLVGEPIMYPEINRFLQLLHHCKISSFLVTNAQFPEEIRNLKPVTQLYVSV
DASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKRQRTVYRLTLVKSWNVDELQAYAELVS
LGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVIRFVRELVDLIPDYEIACEHEHSNCL
LIAHKKFKIDGEWWTWIDYNRFQELIQEYEDSGGSRSFCAENYMARTPHWALFGASERGF
DPKDTRHQRKSRSKNIAGC
>A0A2K6QU26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopithecus roxellana|TrEMBL
MKLPVCVILNLDLSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRNLQ
EKSVPKAPQNLMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKKVTLAVNCPLAVTSKNVCV
FLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLGNSAYSSHFNKVGK
NVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQLQALQKGERKKYCG
GHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDRQSLNSIVD
VEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITAALREALTKQGYQLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPE
INRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFW
QRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFIEVKGVTYCGESSA
SSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKFKIGGEWWTWIDYN
RFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQRKNKSKAISGC
>A0A8H6PEY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus hiratsukae|TrEMBL
MMAEHSTTEGLLAFWHSYRLLFLVALSTVFVALRFYRKLQSRTKTTASSSVPPSPRSQSP
EKTEKGVSLESSNPGTTQKAEGQLTVANGPAKGTSGPKRVTGKKPSKVAGRRGQKEDAEP
LSFIQPIIFFASLTGNTERYAKILLEELRAAAQKRADLQDRERGLLPPQIHELSYIDLDD
YFTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGSLSSLAGYS
VFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGLGDVKSDAESSLKEWSRGL
QDILFDILENGGLGEGVPGSGDPVESDEELDDEDVDKSNAQNVMDLEDIKFGGDQNSAGS
PIPVDFTTTGKSPSGQSTGKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFQGVKE
GHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGEHISSFLV
CNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHIQR
TVFRLTLVKGFNIDDEVVGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEE
VAQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKE
KADGTTFTPEDYMRETEDWALWGNGGFDPNDERVYNKGKKKNLQITAEP
>A0A533X1Z7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEHVSHSTDNLIQITPQLKARLQKAKYGVYNHSAVELCHWTRKSFANEGNCYKHKF
YGISTHQCMEMTPAAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDAIVEQLMAERKKLI
NGYYGNTKNDKRKLDESLLPAHYAISLSGEPTMYPKLPKLIKYLKSLKATKSIFLVTNGQ
EPDMLRRLTAEDALPTQIYLSTNASNKKMFHQINRPLHKDAWERWWESLCFLATVNTRTV
LRMTLIRGYNDSKNFVGEFGEMMAKGNPHFIELKSYMHIGMSNRRLEQDHMLEMQEVRDF
AIQLCEKMSSFKMMDESEVSRIVVLQNQARYTDRWIKEYIMPAS
>A0A1V4YWH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocella sp. PtaU1.Bin125|TrEMBL
MSLIDLLKKQGYHIIGTHGAIKPCLWLNRSIKASGSCYKASFYGISSHRCVQMTPCIACN
QRCLHCWRPVEEPFSIESWDRPELIVEQSLAEQKRFVSGYGGTGATDRQAWKEALMPKHA
AISLVGEPTLYPYLDELIAQYRDRDMSTFVVTNGTRPGVVARISPSQLYMSLDAPDHETY
LKACNPVSDLWDRVNESLEVLRSRPGQRSALRLTLVKGLNMIDPEGYARLVKKAQPDYVE
VKAYMHLGYSRYRLPREAMPSHAEVLAFARKVADAAGYRPAMDVELSRVALLSKDGSARP
IG
>A0A5N1L556|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. CBA1130|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRGTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVRAFTQEMGEYLPNHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWEQDALVDY
>A0A063ZFW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp. MH98A|TrEMBL
MHSEACKALKKQGYQFITPTSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LKCNQQCLFCWRSFEHEVVEEEECPPDVIVANLRRVQKKALSGYKVSPYVAPERFAEALD
PTMVAISLSGEPTCYSRLPELVDALNADGYTTFLVSNGTRPDVLARCRPYQTYVSLDAPD
RETYLALCRPREDYWEQIHESLAGLRERRSAIRTTVVRGYNDFSPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRTQMPEHREVRAFSELIAKHCDYSIRDESPVSRVVCLERDV
>A0A1Z2TK25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 5-4|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPSQLYVSLTAPDVETYNRVNVPMIPDGWDRIKTFLEMMNGLPTRTVVRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGYSRNRLTINNMPRHEEIKAFAEELVKNLPGY
HIEDEYEPSRVVLIMRDDVDPRGSGREGRFIKH
>A0A7J3ZBZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MAVRLQVVKDPYKEINDKLRAQKYHLIGSHSAVKKCLWTHKAVYEGKLCYKGKFYGIESH
RCIQSSVSTQWCWNACIHCWRLRPTDVVDEWDEKGLISIDDPRFIVEMSIIEHRRTISGY
KALGVPEDVIREAMDPKHVAISLTGENTLYPRLGELIKEYHRRGITTFLVTRAVRPDILA
NLDEEPSQLYISLETYDEEGYEFFTAPLVANAWRLTMETIEILPSFTCPTVYRITAVKGW
NMDEKAVKGFARLVEIGMPTFIEVKAYMHVGTSVTRLTRDNMPTHEEVLRFAEDLAKETG
YKLVSHSRPSRVALLSKLDKPLIRHGNAKISWWDPDYEGEDEYEHQSIYGIIATK
>A0A7M3X9I0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPIDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDQVCRPKWNSGAWDQFEKTIDLMPSLDTRIVCRHTLMKGVNMSDAHIKEFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARKVLSDSRPSRVALV
GTEITPIPIPEPMMFFPEDLGIAPPVKHLPVLS
>A0A2J6PI16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyaloscypha hepaticicola|TrEMBL
MAHETWVFRSWLPFEIADIVAVWHEYRIPIILSTFTILMIFRTVLHLRSSRGKISHTPPI
SPSLTAQKGNLLGDKKANGEKVPRRIVGGLKKRKSSEDAVQIGSQKIQLLVFFSSLTGTT
EKTAKVFREGLAKSTQNLGDATTTFLEPQLLDLSYIDYDDYFITAPKTEEETRFFYLLLL
PTYNIDTVLDNFLEHLQETHNDFRVDTAPLSTLLGYSVFGFGDRGGWPTEEEGFCSQARG
VDKWLAKLTGKKRAFPLGMGDSKTNAAERLQEWKEGVLDVLGHIARTGGLGEGVVGSGDA
VESDVEDLDEDDEVLSDEQNVAQRKTKLQKKDGLNDLEDIGSTLNKSSVDLSEPLEVDFT
TYSKKSQPTAPATIKEMVPKNSPTYNALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYK
YSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIFAGVKAGHYQK
IKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHAEHISSFLVCNAQH
PDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILRERRFEQRTVFRL
TLVKGFNIEDEAEGYAALIEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVCSFV
EALNTALAKRGLKYGIAAEHAHSCCILIASERFKKDGKWRTRIDYERFFECLESEETFKP
EDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTESQGEVMGDVA
>A0A2G8KUJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stichopus japonicus|TrEMBL
MYFRYCFVGVAVVCLTAVTSSVLAHDVRSRTLNQDNDSDTLSRLFYYLQDWMPCCHGSAY
IAGAMVLLCTIAFVNTFLNRQEKPSSPSSQESSTSSKAVESKKEDGVSSGNDVWVFYGTQ
TGTAQKFADSLKKKFVDSKLGVRVIDLKTFDPEQHILPDFVKTSTLVFIISTYTDGQPPE
SAAWFYNWLEESVNDFRVPRTLLSGVKYSVFGLGNSLYKENYNKVSRSVDVWMKTLHATP
VLGRGYGDANVANSKHGGAEGDFDVWAKKIVTLLKAEGTPNGKTVANGVKAKIQEEEEEE
TQEEVFEDEDDDIESSKNVLDVEDLGVMMKSSQKKNEAGDSTKEMVTPMIRQSLTKQGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNP
VGTEWKWKMDQPDVIVKGAMENHYKLINQFKGVPGVKDERMQEAMKIKHCALSLVGEPIM
YPEINTLVRMLHGHEISTFLVTNAQFPNAIKQLLPVTQLYVSVDASTKDSLKKIDRPLFK
DFWQRFLDSLRALLDKGQRTVYRLTIVKSWNSEEIEGYAELVDLGKPDFIEIKGVTYCGE
SKASTLTMQNVPWHEEVLGFVQNLVDLLPDYELACEHEHSNCVLLANKKFKIEGRWHTWI
DYTMFHKLMRKFEESKGQESFCAEDYMAETPSWACYGSEERGFDPEETRFRRKNKKQDIS
GC
>A0A0U3RY68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 2319x1|TrEMBL
MDAKTNMPGEIENLFKKQHYALIGHHSSVKLCHWLKESIKHDRFCYKQKFYGIQSHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPQPWDEPSYIVEKSIEAQRKLLSGYWGVKDQIN
VRKLEEAMEPKHAAISLSGEPMLYPMIGDLVEEFHKRGFTTFIVTNGTEPEVLEKMIKEN
KLPTQLYVSLTAPDEETYQRVNVPMIPDGWERINRTLELMRDLPIRTVIRLTLVKDENMH
NPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVKYLPGYHIE
DEYPPSRVVLIMRDDISKKDRFIKH
>A2EUJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichomonas vaginalis|TrEMBL
MTNSPLFKQLPDNYLQCLCCSHYCQIAPGKLGKCRIRGNNNGQPVLPTYGRYTVAIDPIE
KKPLHHFLPGSSIYSYGTVGCNFSCQFCQNSSLSMWGLDIEDVGCIHESDIGRLKKLTPE
RVVSSAIKNSCQSIASTYNEPTVSSEFSHEVFKLAKEKGLYTVYVTNGYESVECLDYLAP
YLDAVNIDLKSFNDKFYMKTCGGHLEPVCNTIRRCYAMGIHTEVTTLIIPKNNDSDEELT
AAANFLASVGKDIPWHLSAYHDDYNFEGFGRTPLETLKRAAAIGKKAGLKYVYMGNVQAP
EARVTRCPNCGHLLVDRIWFGTEVKMKGGKCEKCGEVVPGFFSDANNLKPKLTRVPDHLR
NLSNSPVTAKIESKLPQKFVIYATQGGTSQEYAEKIAMQFGVDAFNIADIDPNSLSSADE
IVFVLSTYGRGNPPQPATKFWETLKSTDIDMKNVKFTVLGCGSSGYKKTFCGFAKSVFER
MKELGAQELAPLCTRDELDDDETYPEVTKWIDALKL
>A0A642UIG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diutina rugosa|TrEMBL
MSLVLFVACVAVHLLSGGRVSVAAAASVAVWMYSRHRLLCEPCNGSAAPMAAKANGTPTK
SGVDRPIYAVDFTGSIPEGTTSLPQPSKPRKLRTRSAKATPKVIKARHPLDVALTRRPIY
VFYTTLTGSSERVAKQMFDTLTSMAQDNDGPLPKLLSLDDDVDELEEYFLKSPKHAIYVL
VLPSYETDSPIDYFLEHLKDVAQDFRVDKYPLRQVSFAVLGLGDRESWADKFCYQAQLAD
KWMGKLGAQRLFPLGQVCLKNDGEPAAHQWSFKFAQMIQENAPVMASVDSDDDDGDGAEN
GDEDGADVEDLLATVTTKEMVAKDSPTFKSLTKQGYTIVGSHSGVKICRWTKSALRGRGS
CYKYAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWTVDPPDEVLAGALAG
HYAKIKQMRGVPGVQMDRFDEAFTVRHCALSLVGEPIFYPHINELTAMLHAKHISSFLVC
NAQHPAQLRALSRVTQLYVSIDASTKEELKRVDRPLNSDFWERLTECLDILRTAQSHQRT
VFRLTLVKGFNMGDIAGYADMVERARPSQIEVKGATFCGSSQANGNPLTMQNIPFWDECQ
RFVRDLETELQKRQLPYQLAAVHAHSCCVLLADTKFKIDGQWHTHIDYAKFFKLLESGAP
FVDTDYVAPTPPWAVWGSAEGGFNPEDTRFDRQAEKAKRRQQREQAQQRAAAAAAAMASA
>A0A497SFS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIMIDEKTKGDLLKKHYGLFNHSGVQVCEWNRKSLRGTGVCYKEQFYGIDCHRCMQFSPA
VIICNLNCIFCWRPNEAMIKEFGAEFDEPEEIVENLIKLRKKLLSGFGGSVADKKKLEES
FDPNHFAISLSGEPTLYPKINELIDYLTERARTVFLVTNGTRPDVLAKLKPKKNFQLYIS
LNAPNEEKFLQICRSTDKDNWNKFNESLKIMKNFKGRRVIRLTLIKNLSFDYNFIDDYLK
LIELASPDFIEVKSFMSIGNAKERLGVGSMLSFDDVKEFAEKITERSNYKLDDYKEDSRI
VLLKNKDSKVVNKFD
>A0A497T6Z8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MMEKIRKELEKKHYKLFNHSGVQICEWTKKSLRGEGVCYKEKFYGINCHRCMQFSPSVVF
CNLRCLFCWCPNELFINKFPEKIDEPEEIVKNLIEQRKKLLSGFGGSVKNKKKFEESLEP
NHFAISLSGEPTLYKKIVELVDYLTERARTVFLVTNGINPEILPKLKKKKNFQLYLSLSA
PEKEKFEKICRPTEKDGWDKFNKSLEIVNKFKGRRVVRLTLIKGLNDSDEDLKGFLKLIE
KGNPDFVEVKSYMSLGYSKKRLGDEKMPDFEEVKKFALKISKKSNYKYEDESKDSRIVLL
KNKDSKVINRFE
>A0A836BJS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGEVVQEEELIQIKPGVLQQLKKAKYGVADHSTVQLCHWTKKSFKNEGDCYKHKFYG
ISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEIVAEPEEILTKLMEERRKLIMG
HYGDIRSDKQKLDESLRPSHYSISLSGEPTMYPKLPELIKYLKSLKATKSIFLVTNGQEP
DMIKRLSDEDALPTQLYLSTNAADYESFLKINRPRYKDSWERWNTTLEMLKELDTRTVLR
ITLIRNYNTSDEMIPDLASMIKRSSPHFIEVKSYMHIGRSTNRLERTHMLEFDEVKHFAS
ELASQSKIFSVMDESEISRIVVLQNQERFIDRQISAYLETN
>A0A453LXF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aegilops tauschii subsp. strangulata|TrEMBL
ARLANAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAPPPGAAFLARWLAETAADFR
AGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGAVEVLPVGEGDVDEGDLDDV
FEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDDDDDEEEEEEVASAEVDMED
IAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQGYKIVGSHSGVKICRWTKS
QLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDDPLDIV
NTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINTLVDDLHRRHI
STFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSLHDK
DQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTYCGSSATSKLTMENVPWHAD
VKEFSEVLASKSGGVYELACEHVHSCCVLLAKVDKFKINGKWHTWIDYDRFNELVSFPSR
IINTGVEHLCR
>Q0W0G8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)|TrEMBL
MESTVTAANLIDLLRKQGYHILGRHSAIKPCLWLNRSIKAKGSCYKAQFYGISSHRCVQM
TPCVACNQRCLHCWRPVEEPFTIESWDKPELIAEQAIAEQLRFVSGYGGTDSADKAIWKE
AFKPKHAAISLVGEPTLYPYLDELIELFKSKEMSTFIVTNGTRPDVLAQISPSQLYMSLD
APDHETYLATCNPAGDLWNKVQESLEVLGSRPQQRRALRITLVKGLNMKDPAGYARQIST
AKPDYVEVKAYMHLGYSRYRLPREAMPRHAEVLEFAKDVAAACGYKLAMDVELSRVVLLS
RDGTARRLE
>A0A7C8V6N2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MSGSSLTTIYLFLLQILVAQHSFAWQQINIETGGEDWFRSSVAPSPDYYRHSSYSDLSQC
YRTPKARPMHLKGIAIWNRHSYDQSPDIRSVGFYNNSNCNRLTQGNGKYEIRSVPYAIVT
LDPAKLAGVSVVDLTETGIEVFASSWKAIDIERERQTGGILVDVPDTMLSDSILIWRGEG
DPEVPAGQQGWEPLTGGVTHLDPGLWSYLTGSMLNLYLREMAERVLNPGWIEIPGAVEKS
ISRLMNPYISLRNNEVVKPMLGEALRNGPQRLLELPYVSMEWARPYSVHPFIGVNSLSGI
EFQGRTGPGQLNAIERRRGGSLTSRRTPQEMQLDLSLASIISEPLASLKTNKPSQSAVEN
SLAASGNRHWWMGGIIAQWEYMTSVLLEARRQYNQLEFGSPNRGPQGQLQIANQAEPQSN
GIDIEYLGALPGRQAQLPIQQNRFQDQFGGRVIPEGSILRESRMSPEKEVQTVRRIKPSS
NRGTQTEPVEGDIETQTENPTRRIQLEIDTQTDPIQMMRGIQTEEQLQPQSNMETQTEAP
IRPETGIQTEDPIWPEMGIQTEGPVRLEFGMQTERPIQPDVQIQTEGFINPEAGVQTERP
ALAEMEIQTEQFIGPEAGIQTERPAQLEVELQTEERPEIEMQTERPTQFEVELQTEEQPQ
IGMQTERPVQRQMEIQTEHFREPEAGIQTERPAQTEIETQTDYFMEPETGVQTDRPARTE
MEIQTEDIIIPGIGIQTEGQAPAGGHRHAAHQIDLEDFRVNLESPAQSSPSYRSGEQSEA
WPDAQIRLRLNQPQNVRIEPENILNSDVSSPEHQSSQEQSETDPREQSEIGALGQLVNEE
TYLLDADAADQEGENATNQLALDEIYQSETGSAHQPETGEVYQSEVSSRSGSPEDQLEES
SLYEPSEEPSRGSSQYSPLRDELEGQQEDPNGQVQSEVQIQSDIDEEDLGYQGQMEMSPP
LILLGTGMPELEVPSVGINGIQNADFRNINDLSALRNFDPHFLDQEELRRLLDSNRRQLE
PARSNPATSPRRYNFNSLAEAVPRVDPSDYLLQKLKEAGLEPGAMSSIDFPGESFTGDDF
QGAEDDLEDDMGNYRRQRPRQNLPNLGLGRFIVPMAEIFKSRSPDLIELWHTIRIPLIIA
IGVLYITIRLRSILRARTPVITAPPSPSKLEPQLCAEPDGTVILPEKFEATSPSNKRRKL
SPAKNVPKRITGGEARKKKPVKSNADAPPAIERVGENTQSNGKSIQVFIFYSSLTGSTAK
YAEKLSNDLFSEPLHIPTPTPPSVDNAEPEPAVEKATFLPPIVENLDYLDLDDYFISPAT
VKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETHNDFRIDTRPLRSLAGFSVFGFGDKEG
WPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFPVGMGDVKGDALDSMDEWRKHLEIALN
DLATGEILPESTGVDSEDEEDVAQDAATTEPLVDVEDIGNSIRSSKPPKSKKSSAPLAVD
FTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVGSHSGVKLCRWTKSALRGRGSCYKYSF
YGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWNWVVDPPEMILSGAMEGHYKKIKI
LKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPHINEFLSMLHARHISSFLVCNAQHPDQ
LARLKYVTQLYVSIDASNKESLRRIDRPLHRDFWERFMKCLDIIKAKKDRMRTVYRLTLV
KGFNIEDEVEGYADLVEKGLPAFVEIKGVTYCGTSTSVGAGLSMQNVPFYEEVCEFVKRL
NEALQKRGLEYGIAAEHAHSCCILIASNDYFIDGRWHTVIDYQKFFELLEEGKEFGPLDY
VGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTAEEVAAELAAEAAEAESGCG
>A0A7C0UQF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp|TrEMBL
VKLCHWLKESIKNNRVCYKQKFYGIESHRCLQMTPVTAWCTHNCIFCWRPMEGFLGVELP
RPFDDPAFIVEESVKAQRKLLSGYWGVKDQINVKKLEEAMEPKHAAISLSGEPMLYPMIG
ELVEEFHKRGFTTFIVSNGTEPEALEKMMKENKLPRQLYISLTAPDEETYQRVNVPMIPD
GWDRINKTLELMRDLPTRTVIRLTLVKGENMHNPEGYAKLIMKAKPMFVEAKAYMFVGFS
RNRLTINNMPSHEDIKAFAEELVENLPEYHIEDEYPPSRVVLMMRDDIRKADRVIKH
>A0A436ZYK6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arthrobotrys flagrans|TrEMBL
MADASKLRSSDLIELWHTIRIPLIVAIGILYITVRLRSILLSRNLVLTTPPSPSKLEPQL
CAEPDGTVVLPEKFEVTSPSNKRRKLSPPKHVPKRITGSEVRKKKPAKPNQDTPPAVEEE
GPYWNSKSIQVFIFYSSLTGSTAKYAEKLSKDLFSEPLHVPKPTPPSVETTETQPAVEKA
TFLPPIVENLDYLDLDDYFISPATVKGLNTTSVYLLLIPTYEITSPVDAFLEHLSETHHD
FRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGIFCGQAKEADRWMSKLTGGKRVFPIG
MGDVKGDAMASMDEWRKHLEIALNDLATGETIPESTGVDSEDEEEVAQDASTTEPLVDVE
DIGNSIRSSKSSKSKKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVGS
HSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVSTT
WNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPHI
NEFLSMLHARHISSFLVCNAQHPEQLARLKYVTQLYVSIDASNKESLRRIDRPLHRDFWE
RFMKCLEIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYADLVEKGLPAFVEIKGVTYCGTS
TSVGAGLSMQNVPFYEEVCEFVKRLNEALQKRGLGYGIAAEHAHSCCILIASNDYFIDGR
WHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTAE
EVAAELAAEAAEAESGCG
>A0A8A1LXL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces capsulatus|TrEMBL
MAGDDLQIFAQRLLTSWHRYRIPIFFLAAVVSIVIWLSTRSHKRNTPLSDSLSPCQSEKQ
NQNDKAESCRVELSSKNDPAAAFFPNSDHSGSSIESQVRQAKQSANGPKRVHGSKPVKRG
ANNRTNPGELSRDINIQPMVFYVSLTGSTEAYAKSFCHRLQKATHALIENHSKTAILTPQ
LHDLSYIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRID
TSSLSALAGYSVFGFGDREGWPSEEEGFCSQARDVDRWMAKLTGKKRAYPLGMADVKGGN
TQTVLNDWCDGLSGIMFDLISSGGLGEGFPGSGDPIESDEEDIHDSEENDENGRSFRNKR
KEEQIVDLEDIKFGVTDGKGTSADRQLLPIDFTTQSHPQASKPVSQPQLEMVPTSSPTFT
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWKVDPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCF
VEVKGVTFCGTSTSASAGITMQNVPFYEEVVAFVVALNAELTRRGLGYGIAAEHKHSCCV
LLASNRFYVNDRWHTRIDYDKFFTLLEKEKNNGISFRPEDYMRETDEWALWGNGGFDPND
TRVYTRGKNKAKLNAVLKASEQNATSVEG
>A0A8H7ZBZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces capsulatus|TrEMBL
MAGDVLQIFAQRLLTSWHRYRIPIFFLAAVVSIVIWLSTRYHKRNTPLSDSLSPCQSEEQ
NQNDKAEPCRVESPSKNDPAAAFYPNSDHSGSSIESQVRQAKQSANGPKRVHGSKPVKRG
ANNRTNPGELSRDINIQPMVFYVSLTGSTEAYAKSFCHRLQKATHALIENHSKTAILTPQ
LHDLSYIELDDYFIAAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRID
TSSLSGLAGYSVFGFGDREGWPSEEEGFCSQARDVDRWMAKLTGKKRAYPLGMADVKGDN
TQMVLNDWCDGLSGIMFDLISSGGLGEGFPGSGDPIESDEEDIRDGEENDENGQSLRNKR
KEEQIVDLEDIKFGVTDGKGTSTDRQLLPIDFTTHSHPQASKPVSQPQLEMVPTSSPTFT
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWKVDPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINEFLSLLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCF
VEVKGVTFCGTSTSASAGLTMQNVPFYEEVVAFVVALNAELTRRGLGYGIAAEHKHSCCV
LLASNRFYVNDRWHTRIDYDKFFTLLEKEKNNGISFRPEDYMRETDEWALWGNGGFDPND
TRVYTRGRNKAKLNAVLKASEQNATSVEG
>T0N5V8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon A-plasma|TrEMBL
MENAYTQIYKKQQYGLVGKHSAVKVCHWTKSEITGGKGCYKGDFYGIKSHQCVQMTPALN
SCTENCSFCWRFQGFDSMHISDEDDPEFILEESIKAHRKLLTGFKGNPKVTEEKWNEADN
PKHIAISLTGEPTLYSRLGEFIALARKRGISTFLVTNGTLPMVLEKLDPLPTQLYVTTAG
PTKQIFHDVLNPAIGNAWENFLRTLELLPSLDTRKVIRHTLVKDVNMPYLEEYAKLDSIA
SPDFIESKGYVHVGQSITRLGIENMPSHDYVVDFSRALGSMLGYEFAGERRDSRVTLLAK
DPSRAKIDFSAI
>A0A8D3BZ58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MFTYFKFSKRDILLPFYAPTAQFLTVFCCFHVSIQCTSKSVCVFLVATYTDGQPTENAEW
FCKWLEEASTDFRYGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTR
GEGDCNVVKSRNGSIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQV
VEEKANSEVMTWDDPLIKYQNFKTVKTITAISQIWIKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRG
VPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRT
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNV
EEMQAYSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYE
IACEHEHSNCLLIAHTKFKVAGEWWTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPG
WALFGACEQGFDPADMRFKRRNKAKDISGC
>A0A0J6Y7E0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides immitis RMSCC 2394|TrEMBL
MPDETFASGAQRALSLWHSYRGYALVLLPAVFILSHLIAARGKTAEASPPSIPSPPRSSK
AKQSRPTSGTEPPTSTTTPEEGTPSPNGAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDA
TKEISIQPIIFFSSLTGSTERSAKRVLERLNTEPLKDSKRSSRLLAPQLYDLSYVDFDDY
FVSPPKAPESNPNVLYFYCIIIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAV
FGFGDKEGWPTEEEGFCSQAKEVDKWMAKLTGRKRAYPLGLGDVKTDGDKALDEWCSGMQ
EVLSDMVTNNGALGEGVPGSGDPLESDEEDVEEDDEGVPNPGSRPRKARRAEITDLEDIK
FGGDASGKQGSDIPIDFTTYSKTSTSVATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWK
VDPPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFV
SMLHSEHISSFLVCNAQHPDQLAALDRITQLYVSIDASNRDSLRKIDRPLHRDFWERFQR
CLDIIREKTHVQRTVYRLTLVKGFNIDDEVVGYADLVERGLPCFVEIKGVTYCGTSTSAG
AGLTMQNVPFYEEVAAFAVALNDELNRRGLGYGIGAEHSHSCCILLASRRFHVDGKWHTK
INYERFFELLEREKAEGVSFTPEDYMSETDEWALWGNGGFDPNDQRVYRKGKNKANMSDA
GSVPKGGVVEI
>A0A843F2X7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MSFNKSQQKKLEKSGYRFVGSHGHAAVKTCHWTRQSIVDKGVCYKEKFYGIESHRCLQMS
PAVPNCQQECEFCWRDLTYTQTEWEDDEYDDPKTIVDGAIEAQNNLLCGYYGNEKANTKK
LEEIKKPTNAAISLAGEPTLYPKIDELIGEFNRRNFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPTSKIYDDVCRPRISDAWDNLNESLETLSSFNSRTCIRNTCVKGRNMVNPEKYA
ELIDKANPDFVEVKAYMCVGSSRERLTLDNMPTFDEVKDFAQKIGDECGREITDEAEISR
VVLLK
>S9VUK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691)|TrEMBL
MCFDLAFLEEKWGTYRGLVFYLVLLLPVAAHLIISRNKRQLAVPAEGIVLNEKENGKQKK
TTKRFTRKNMKTRPVQSTSKSQNEIDLQNSPICIFYATLGGTAQRYANEVHKLLSTNLQR
DDLQLLSLDYIDLEEYFLYCPENAVYLLVLPSYAIESSLDFYLSTLRETVYDFRVQKNPL
QKLSGYAVFGLGDMDNYPGDMFCYQAIEADKWLSKLGAQRIAPMGIMNTQLASATQIDVL
TQWTNSVIEHMRKGTLLRPMDEGEGNSDVMDVEDMGPMMAKAKTEASLPIGTKEMVSTVS
PTYKALTKQGYSVVGSHSGVKICRWTKSAIRGRGFCYKYSFYGIRSHLCMEATPSLACAN
KCTFCWRHGTNPVGTEWRWKVDPPELILKGILESHYSKLKLMRGVPGVRQDRFAEASRVR
HCALSLVGEPIFYPYINEFVGMLHEREISSFLVTNAQHPEAFQKMGMVTQLYVSIDASTK
QSLKSVDRPLFKDFWERLLTCLEILREKKQRTVYRMTLVKGFNMEQIKEYTELIRLGIPC
FIEIKGVTYSGNSDQSPLTMKNVPYYEEVIDFTKKLIENIDKYLGDLGVKYEIAAEHAHS
CSLLVAQTKFKKDNVWYTHIDYPKFFELWRSKKDFDPLDYVAPTPDFAYYGNGGFSPEDV
RFVRKQKNKGQPGTTPAPAPVSEIAA
>A0A8H3EQ82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alectoria fallacina|TrEMBL
MEVFGRPAAGSKDRGFLIHGLILDQWHEYRYILLLAAVLFGLAVVVYFDWRLPRERFTSS
PAVSTPEHATAEPGGRLDEKPQSTTLAEREDERSEKPGPYENAAMRLPFVSLRPRPSPKR
VTGSKVDRKPKSESSANGRIQPLIFFSSLTGTTEKRAQLFLSELQTSLKDHSSAVLEPQI
HDLSYIDYDDFYVTPPKSQNTDQHVQFFYLLLLPSYNIDTALDNFLAHLQETHHDFRIDT
APLSGLAGYSVFGFGDKDGWGTEEEGFCWQAIEVDKWMAKLTGRKRAYPLGSADVKSDVE
RGLGEWRDGVVKALLDVAAHGDLGEGVTGSGDAVESDEEDAEEAAEQGTSPRTEARRPTK
QKRPQKNSRVDDLEDLGRKTSFQSMDSSSESPSPLPIDFNTSTTLQATKAMVPVSSPTHA
ALTKQGYTIIGTHSGVKICRWTKSALRGRGSCYKYSFYGIKSHICMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWQVDPPKMIFEGAKEGHYKKIKMMRGVPGVRAERFQEAMQIRHCAL
SLVGEPIFYPHINEFVAMLHKERISSFLVCNAQHPDQLAALKPVTQLYVSIDASNAESLR
RVDRPLHRDYWQRFLRCLDILREKRFRMRTVFRLTLVKGFNIEEEVEGYADLVALGLPCF
VEIKGVTYCGTSSSAGAGLTMQNVPFYDEITTFVEALNAALERKGLEYGIAAEHAHSCCV
LIASKRFYVEQKWHTLIDYENFFECLKSGKEFSPEDYMGPPTPEWATWGNGGFDPADTRV
DRKGKPKIEKVR
>A0A446TGE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSIALRRLRRTLRPSPSPSSSSPAAAAXX
XXXXXXXATGTSKALAERLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGA
PPPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALG
AVEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEDDAVDGETNGFDGLEGEESDYD
DDDDEEEEEEVASGEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEK
QGYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVG
EPIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDR
PLFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVT
YCGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKING
KWHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAA
LKG
>A0A446TGH3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSIALRRLRRTLRPSPSPSSSSPAAAAXX
XXXXXATGTSKALAERLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAPP
PGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGAV
EVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEDDAVDGETNGFDGLEGEESDYDDD
DDEEEEEEVASGEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQG
YKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEP
IMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPL
FSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTYC
GSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGKW
HTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAALK
G
>A0A1Q8RU59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum chlorophyti|TrEMBL
MASSFDSVGFKSTLNDLHDVWQQIRIPVILFTAFGLLLLRFYLHTTEEKGELKALPKAYN
KEKPDSKPKPVDEKKDAKPSPTLESKASKSNGPRRIKGGLVKRPSTEVVDGESLAQKIKT
LIFFSSITANTPKIAKDYAERLGKELEKLAADSGCAFLAPEILDIAEIDFDDYFITPPKS
EDPVELFYLFLLPSYNIDTINDTFLEHLKETHHDFRIDTAPLSSLLGYSVFGFGDREGWP
TEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYAERLSEWSEGVVDVLGMVAKTG
SLGEGLPGSGAPEESDDESAAEDDDEVLIEDSEAKPEKLKSRKNIDDVEDLGRIMKTSGP
DADVTGAPPPIAVDFTTYGKTTPKKTPTSAAKEMVPKNSPTYASLTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVV
DPPELIFEGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFLG
MLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRC
LEILREKRFKHRTVFRLTLVKGFNVEDEVEGYAQLVEKGLPCFVEIKGVTYCGTSTASNA
GLSMSNVPFYWEVADFVKALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYRDGKWHPRI
DYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGKGGFDPRDERVDRKGRKIES
>A0A5B0PIU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia graminis f. sp. tritici|TrEMBL
MFSLVESITSRFNLTNHTNADRPLNTQVLYSSLSSTTKKLANQLSTSLQSSSQHLHSTLE
SLDHLDLDQLIIQTPVDSTYQLAIFLLPSYNVESPVDSVLAQFRDALFDFRLSKNSLAGL
SFAVIGIGHSDYRDEFCKQAIELDEILEGLGARRLLPLQKIDVAVDPERDLDHYYHSIIQ
KTFHPALKSFSELPTIKSQEIKKYSAENQEEEEEEEEEQDDVDNSDDEFVDYSNSKPLSK
AEKARQKSKRLLNKKINQGEKKTNGTQDIEDLGVGVPQIENLTSNSKDDAENQMIKKDMI
SPMTRKSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLAC
ANKCTFCWRSHTNPVGTSWRWKTDDAEFVVEESLKEHDRLIKQLAGMPGVRPDRFTEART
PRHAALSLVGEPVMFPHIKKYISLLTEKRISTFLVTNAQFPDSLLDLPPVTQLYLSIDAG
TKESLKSIDRPLHRDFWERFLESIDIVRKKKIRTVFRLTLVKGENSDEIKEYAELIRRGQ
PDFIEVKGGG
>A0A8J8JTL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|ANME-1 cluster archaeon GoMg4|TrEMBL
MSNYAEETIKTLEKQGYHFVGTHKHSAVKTCLWLRRSIRGEGNCYKGKFYGISAHRCIQM
TPSIFCNQRCVHCWRPLEAFNINTGTEEEQVVWDSPEEIVEDSLKEQKRLISGFKGSPKT
DKDAFAEAEVPRHAAISLIGEPTLYPYLKDLIQEFRSRDMTTFVVSNGTNPEVLREIRPY
QLYISLNAPDEATYKKASHARYWTRINESLDEMGKLKGKTRRVIRVTCIEGLNMINPTGY
AELLARANPDFIEVKAYMHIGYSRKRLSRDAMPTHLRVKEFAREIAEALTSSGYTYTIAD
ESEISRVVLVSSNTDL
>A0A5C7H687|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acer yangbiense|TrEMBL
MSSSSLRARLTLVAILSATTFYFIYKSRRLNKLLRLSLKPKNPENPRKGKLFFISQTGTS
KTLAERLHSHLTSLDLPFELVDPRNYEPEDLPKETLILIVASTWDNGKPPETAKFFVDWL
AESANDFRVGSLLLSRCKFAVFGVGSGAYEKSFNVVARDLSNKMRELGAAEVLPVFEGDV
DGGELDVVFEDWSKRVVAVLKGGEDDHVGNGIVDCDVGMESDDFDDDGGADDDEDDDDDE
EEVESEMVDLEDIAGKGPSRRSKNVAETNGKVTNGKRDMVTPVIRASLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQ
WKMDDPLVIVNTAIDLHTKMIKQMKGVPGVTQERLNEGLTPRHCALSLVGEPIMYPEINT
LVDELHQRQISTFLVTNAQFPDKIKLLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERF
LDSLKALREKQQRTVYRLTLVKGWNTEDIDAYFQLFSIGSPDFVEIKGVTYCGSSATSKL
TMENVPWHSDVKAFSEALSLKSKGEYEVACEHAHSCCVLLAKTDKFKVDGQWYTWIDYEK
FHDLVTSGRPFNSNDYMAATPSWAVYGAEEGGFDPDHTRYRKERNHKPKQ
>A0A0F7ICE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geoglobus ahangari|TrEMBL
MVKSLSDLKGYQIVGKHSAVKTCLWLKKSLKDEGYCYKQKFYGIASHRCLQMSPALICNL
SCVHCWRPLDLMPPFTEWDEPEFIFEESIKAQHRLLSGFHGTEGVNRRKLEEAYRPNQVA
ISLIGEPTLYPRIDELVEVYRRNGFTTFLVTNGTNPQAVERVEPYQLYLSITAWNAESHR
ALQGRDQWGKVEETMRIMAEKDSRTVIRLTLMRNVNMEPEKFVEIVDKVQPDFIEAKAYM
HLGHSRLRLDRSAMPSHEEIREFSERLARLTGYEVKDESEISRVVLLER
>A0A067QHA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zootermopsis nevadensis|TrEMBL
MVTLFGIPLIGTLFIPTLLGFLTFYIIWSLSTRKKDADCTVEQILPSDSALTVNNIGSKP
KRKVFGNRADSVSIGQDDNSYSKGDSNSLPQVKLHYTQNAKRKVFGSKVGELTSLSLQLE
NNLAKKNTRKKRCKGKSRCCSKKKGPSKVLEGTIEIVKVFFGTQTGKSKTFSTKLGRCCE
QIGLSVELVDLASFDPEERLLEETSGKSLCVFILPTHTDGKPPESAAWFCKWLEEASNDF
RVERELFKGMKFAVFGLGNSQYKDHFNQVGKQVDRWLQDLHAARFIKLGVGDEDTSASKR
GSIEADFQDWIDQLWMRVDRFRTACQCDGSEQEKAESSCDSSSEGCDSDGNSSGQDSHGT
GVIDLEELGAFSSSFRAAREKEVEENSPREMVTAALRDSLTRQGYRIVGTHSGVKLCRWT
KSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDPPDK
ILKDSLENHYNMIKQFKGVPGVLPERFAEGMDVKHCALSLVGEPIMYPEISNFVLLLHEH
GISTFLVTNAQFPKALRDMGPVTQLYVSVDASTKSSLRKIDRPLFKDFWERFIDSLKALS
EKGQRTVYRLTLVKSWNVDEIMDYSKLVEIGKPDFIEVKGVTYCGTSKASNLTMENVPWH
EEVITFVKKLGDLLPDYEIASEHEHSNCVLLAHRKFKVNGEWWTWIDYNKFHELVQRYYS
TDGASTFTAEDYMFKTPPWAVFGASERGFDPVEKRWHRKRLPGKDISGC
>A0A4Y8DIE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryotinia calthae|TrEMBL
MAYDSWISRPVWSFGIDDVVALWHLYRIPIILTTATILILVRITLRPRALREKLSASPLP
TSPILSAAKEKISPPVINKKKANGVKAPRRIVGGIKKRKSSEENLQAGPEKIQPLVFFSS
LTGTTEKTANSFVESLTGDLSGRANGQRIQFLESQLLDLSYIDYDDYFINPPKGESGTSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVDDVEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTASEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTG
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASNRFNIEGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGIV
MGEVQDAGEDKVAEDSTKDDLAF
>A0A1D2UZM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp. 2-GBenrich|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A5A7VC83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cucumis melo var. makuwa|TrEMBL
MSFSSRSAKLTILALLSASTLYCFYKSRRLRKLKLSLNPTLSSRKPKLFFISQTGTSKAL
AHRLLNVLNSNGLVFDLVDPKDYEPEDLFKETLVLFVASTWEDGGPPPHAKFLANWLSES
AEDFRVGSLLLSQCKFSVFGVGSRVYGETYNAVARDFSKRMKALGAKEILPIGEGDVDGG
DIDKCFDDWSRKLLKVVKVDAEGNGVELCSGIAGDSDAVSVEEEYEEEDDDLGEEDIVDL
EDIAGKGPSRKSTNVVETNGKLNGKKVMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPLDIVN
SAIDLHTKMIKQMKGVPGVTQEKLEEGLSPRHCAFSLVGEPIMYPEINTLVDELHQRRIS
TFLVTNAQFPDKIKLLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKALNEKQ
QRTVYRLTLVKGWNTEDIDAYSNLFSIGRPDFVEIKGVTYCGSSNTSKLTMENVPWHSDV
KSFSEALAAKSQGEYEVACEHVHSCCVLLAKTDKFRVDGQWFTWIDYEKFHDLVASGKPF
DSKDYMAPTPSWAVYGSDEGGFDPDQSRYRKERHHKPKPTS
>A0A838YPF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGETVEEEDRLIQIKPAIAKQLKKAKYGIADHATVALCHWTKKSFKHEGNCYKHKFY
GISTHACMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPKQVAEPEEILTKLMIERKELIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLHSLKATKSTFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFKRINQPKYDDSWERWNRTLSMLKHLKTRTVL
RITLIRDYNDIKEMIPVFAEMVRKASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEIKNFS
EQVAKQSKIFSVMDESFVSRISILQNNERTIDRYIPTYANTN
>A0A8H3IAU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gomphillus americanus|TrEMBL
MEALGRIGTSQSCSSSFESHDDCNAGLLAVWHLTRLPILCILAGVFLTLKWWLSRRNSVG
LGEQIVELKIPAQTFQPLSKPITEPGISNIQPTPTPVTKPSLSRAKREPKRVLGSKAGRR
VSPKSHPNSETASIRIQPMIFFSSLTGSTEAYAKSVQEQLIEKASASTLEPQIYDLSYID
YDDYFISAPESEAGIKYCYLVLVPTYNIDTVLNNFILHLEETHHDFRIDNAPLTGIIGYS
VFGFGDREGWPTEEDGFCSQAKDIDRWLAKLTGRRRAFPLGMGDVKADAKARLMEWVGGI
VETMSNIAETGSLGEGVIGSGDAVESDVEEDDTEDKVKSTLGDLEDIGIRTNTKTSLAID
FTTTDTNTLKPMVPKTSPTYASLTKQGYAIIGSHSGVKICRWTKSALRGRGSCYKRSFYG
IASHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEMIYDGAKEAHLKKIKTMR
GVPGVKAERFQEAMRIRHCALSLVGEPIFYPHINEFLTLLHNDHISSFLVCNAQHPDQLA
ALNNVTQLYVSIDASNKESLRKIDRPLHRDFWERFIKCLDIIRSRRYDMRTVYRLTLVKG
FNIDDEVSGYADLIARGLPCFVEIKGVTYCGTSTSAGAGLSMSNVPFYHEVQTFVTALDT
ELAKRGLHYGIAAEHAHSCCVLMAASTFKRNGKWCTIIDYDRYFQLLESGEPFGPEDYMG
EDTPEWALWGNGGFDPADQRVDRKGRAIEI
>A0A832TPQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfurisphaera tokodaii|TrEMBL
MVSNLRIDTLSLIMKELEKEKYHIVGNHSVYKKCHWTHEALTSGRYCYKGKFYGIESHRC
VQMSPTAAWCWFRCIHCWRLEPEDIGIEWDETKLPVEDDPDIIVEKSIEEHKRAVSGYFG
REGVDKNKVKEAITPKHVAISLTGEPTLYDRLGELIKEYHKRGLTTFLVTSGVRPDILAS
LEEEPTQLFVSLQAPNEFKHKLINRPIVANSWNLVMKTLEILPSFSSPTVIRMTMIKGFN
MSDEDAREFARLMEIAQPTYIEVKAYMHVGPSTYRLSKDAMPRHFEIKEFAKKLAEYTGY
KILSEHIPSRIVLLSKLDKPIQIGNAWTDNWNWATKDIEDDINGEYKEAELGCTEGET
>A0A0E3SJ19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina horonobensis HB-1 = JCM 15518|TrEMBL
MPLEEKKEEKENSRESLSEVLEENRDEEQTPIPFDIPDFETLLKKQSYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGAWDSPK
KIVEESITCQRKLITGFGGSPSALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDASDLETYLRVCQPKSPALWDRINESLEIMK
EKSSRTVIRTTLVKGENMFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLDRSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKPVCPS
>A0A445GBK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glycine soja|TrEMBL
MSISISLSSVPARLTLLALFSATTFYCLYKSRRLRHLKLSLNPNPNPNPNPKILFLSETG
TAKTLARRLHRLLSSNDVAFDLVDAQHYEPEDLPKETLILLVASTWQDGAAPAASRFFAT
WLADAAADFRAGSLLLSRCRFAVFGVGSRAYGDDSFNAVAKGLARHLRALGATEAVPLSE
GDIDGGDDVDAVFDRWCEKVVAVLKGVGVVESCDNDGAEECGVVSSSEEESDVESSEIVD
LEDIAGKAPSRRKVVANGEESNGKLNGSREMVTPVIRANLEKQGYKIIGSHSGVKLCRWT
KAQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIE
IVNSAIDLHTNMIKQMKGVPGVTLERLSEGLSPRHCALSLVGEPIMYPEINALVDELHKR
RISTFLVTNAQFPEKIKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALK
EKHQRTVYRLTLVKGWNTEEVDAYSKLFSLGEPDFVEIKGVTYCGSSTTSKLTMDNVPWH
ADVKAFSEALALKSQGEYEVACEHAHSCCVLLAKTNKFKIDGQWYTWIDYEKFHDLVASG
RTFDSRDYMAATPSWSVYGSEEGGFDPGQLRYRKERHHKSTRNQAG
>A0A7K6B8I6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Upupa epops|TrEMBL
LDVSVDMWDLFCTCLVSLWLHRIYIYSAVAFGISIWIIIQVISTKTRKKVTEQTTPVRES
LEVSGIEDKLANGYTVVQPKEDFVAGVKIFYGSQTGTAKRFAKALAEAVISLHLPVEALN
MGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAASDFRFGKTYLKGL
RYAVFGLGNSVYVDHYNTVGRNTDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAW
KTKFLGRLQALCSGEKKPCSGKCKKGKCRSPGKQSKECSDHEHGASEYENTEAEELFETS
SEEEADAEEAESTNSVVDVEDLGDIMSHMKKAKRDGELEDGDVGMNLTGDSTGKKEVAEK
REMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATP
SLACANKCVFCWRHHTNPVGTEWRWKMDQPERILQEAIENHQNMIKQFKGVSGVKADRFE
EAMTVKHCALSLVGEPIMYPEINLFVKLLHQHSISSFLVTNAQFPEEIRNLVPVTQLYVS
VDASTKDSLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLI
ALGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELVDLIPDYEIACEHEHSNC
LLIAHKKFKINGQWNTWIDYERFQELVQEHEMSGGAKTFSATDYTARTPRWALFGSREKG
FDPLDIRHQRRNKARDISGC
>A0A671WG98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sparus aurata|TrEMBL
MSIWHNRLYLYSAAALVFGIWFSLKVALKKKSFSKDVGTLVYRAVKNNDRDTVVHLSGVK
IFYGSQTGTAKGFAQELSEEVKTLGIPAEVIDMKDYDPDDQLADECSNKSVCVFLVATYT
DGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLW
MLSGMRVMTRGEGDCNVVKSRNGSVQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGS
CKSKRRDTQEEEEEEEEKAALKNNGSEEELIESSSDDEESGPQDEEKSASVVDVEDLGNI
MNSVKKAKSRGDGQMVKLSKLNGMGKIEDEGERREMITPALRDALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPTLIKSKGGADSTTFLTPGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLH
SHHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRA
LGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVP
WHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQTH
EESGGRQSFSALDYTAKTPSWALFGANEQGFDPADTRFQRRNKTKDISGC
>A0A2Y9I383|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neomonachus schauinslandi|TrEMBL
MDPSLDTWDFSSPLMSLWMNRFYVYLGFAFGISLWICFQIVIRKQLFIFKDKNSQKSVTK
ATGDLMTNGYIPLQKKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKEY
DPDDHLVEEVTSKNVCAFVVATYTEGRPPESAEWFCKWLEEASSDFRFGKTYLKGMRYAV
FGLGNSAYASHFNKVGKNVDKWLWMLGAHRVATRGEGDCDVAKSKHGSIEADFRAWKTKF
LARLQTLQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGK
IMNYVKKEKREKEQQEEKSGLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLK
LLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDS
LKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMA
NVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQELM
QEYEDSGGSATFSAKDYVAKTPHWALFGACERGFDPKDTRYQRKNKSKDISGC
>A0A218P081|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus celer Vu 13 = JCM 8558|TrEMBL
MAITFQSNPNMPEEIARLFQRQHYALVGHHSSVKLCHWLKESLKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRRLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHRRGFTTFIVTNGTVPERIEEML
REDKLPTQLYLSLTAPDLETYNRVNVPMIPDGWDRILRTLELMKDLPTRTVVRMTLVRGE
NMHNPEGYARLIMKARPMFVEAKAYMFVGFSRNRLTIDNMPKHGEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPHASGTGGRFIKH
>A0A6Q2WWM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
MGKEVKTLGIAAKVIDMKDYDPDDRLADECSTKSICVFLLATYTDGQPTENAKWFCKWLE
EASTDFRYGNNYLKGLRYAVFGLGNSVYDSHFNTVSKNVDKWLWKLSGVRVLSRGDGDCN
VVKSRHGSLHSDFLVWKTKFLSRLQTMVAGPKACRGKCKTGGSCNNRKKPQKTDDEQAAP
EHETSHHATSISMLLPCNTMQPCEARVTNTENARLKIQQKSHLSKCLCISWTESVIDRLL
KVQICDHITFSTFCSTGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETT
PSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKILLEAVENHQNMIRQFRGVPGVRLERY
QEGLKVKHCALSLVGEPIMYPEINAFLCLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYV
SVDASTKDSLKKIDRPLFKDFWTRFLDSLKALGEKRQRTVYRLTLVKAWNVDELKSYSEL
ISLGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVQQLVDMLPQYQIACEHEHSN
CLLIAHTKFKVDGEWWTWIDYERFQELVQAYEESGGSQTFSAMDYMAKTPMWALFGASER
GFDPTDTRYQRRHKTKDISGC
>D8RBB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Selaginella moellendorffii|TrEMBL
MEKLRGWLTRGADRGAGDCSCKGECNSNDDGVGGGGAVKLKLLFASETGTSAALAKRLAG
KLGERGIPVELVDPSGYEPEEFLKERLVVMVVSTWEDGNPPKHAAFFVNWLAESSTDFRV
GSKALAECRFAVFGVGSREYGSKFNAVGRAVEKYMADLGAQRLVERGEGDVDGGRLDATF
DGWSARLVRKVKEFLERDSIAVEPAAAVEGDESDDDGEFDDSKEDFDLEDLAGKYPRATN
GKPVSDGEAKEMVTPVIRSSLEKQGYKVIGSHSGVKLCRWTKSQLRGRGGCYKHTFYGIE
SHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDDPLDIVTTALDHHKKMIKQMKGV
PGVKDDRLEEGLRPRHCALSLVGEPIMYPEINTLVDELHKRHISTFLVTNAQFPDKIASL
HPVTQLYVSVDAATKERLKAIDRPLFSDYWERFIDSLKALLDKQQRTVYRLTLVKGWNTA
EITAYAELLKLGRPDFIEIKGVTYCGSSKTSTLTMENVPWHEDVREFSEALSAETRGEYE
LACEHVHSCCVLLANVSKFKADGQWHTWIDYDKFQELVTSGESFSSEDYMATTPAWAVYG
AVEGGFDPTETRVRKERRHGGGGVSGGCT
>A0A094DQX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4515|TrEMBL
MANNDLIGADIASDAMGNYLMVLWHTYRIPLILTVLALLLLTRTVLHLKVGRGKIIYTPP
ATPTEKTPLAANLKREELTEKAPISAEVKKAGPKRVVGKVTRKKSPLRDQPASKDVKFQV
LVFYSTLAGSTERTAQALTTKLADTLKANAGSGQYEFLSPIAHDLAELEDYDEYFLGLPK
PEDDGLDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWLAKLTARKRAFPLGMGDTKVDAQDRLDEWRQGIEDVLQNL
GQTGNLGEGVVGSGDADESDVEDADEDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQAESEDQDQDEDEGAIDFTTYGKKTPAPVAAPKEMVPKGSPTYNALTKQGYTIVGS
HSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYL
NEFTAMLHKERISSFLVCNAQHPDQLATLKPVTQLYVSIDATNRESLRKIDRPLHRDFWE
RFQRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTS
TSGAAGLTMQNVPFYEEVCAFVLALTAALEKRGLKYGIAAEHAHSCCILIASDRFKKEGK
WHTRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRV
EGEEAEPKEVETKEGGDKAAHGIQVSPRRPGGFQNQPTISRLQAPTSSQSADGRPMGLLV
AVRQRVAMLSGDAKATLVAGNGFERTGCATLLGLTTKRIPTICTGSTFLSQNGGSAATLY
GAWSPMYKPESSRSKAIPNKDILLYRSAYTHLRLELMSEPIAIDGIEACLSQYGYSRETT
YRDLSMISGAHLSSIYHRIHGRPSKREAAYNRQYLTYEEEEVIATCLLSMAQSGYCLPRQ
FIRKIAHHVKRQRNSIEPVHQYQSGGDGALRPGKNWSTTFWKRHPTLKIALEIPKKNTKK
SDQHIFDHIDAWINIIAPKLDTLKALNKNTYHVIATGGILKFPAIIPEIVSEDTIHAYLN
ANDKGKVLTAIECSSMDGQFINPLIISPTVAERNQTLDHVFNCHFDQSSNGYLDSEVAIK
WVTNIFEPHTRAVANGRPRFLISDALTYYNTRELRVFCKKNRIHLCGLHSMVVQRLQFHT
ASSFEQLQISLREEYSRAYSYSRDCEKLQFSLLYDRARQRAIDVHTTQAQFQDEDSSEAS
IDSSASSFEDSPQTIEDTAQTTKDTPKTVEGLVSLCQNIENDLKCEALSEAVKGRIQHLL
DIAMIGATI
>A0A8C3HNH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chrysemys picta bellii|TrEMBL
MLNFWLVFQVLTILAACADAHAMDASADTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWIC
FQFIATKAKKQDEKSTEKLTPSKVTQDVLINGYTMPKTKEVYVAGVKVFYGSQTGTAKGF
ATILAEAILSLNLPAEIINMRDYDPDDCLVEEATSKNICVFLVATYTDGQPTENAAWFCK
WLEEAVNDFRFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEG
DCNVAKSKHGSIEADFSAWKARFLARLQALCKGEKKPCSGNCKKGKCKSKGKKSKEGSDH
EQRVSEQENTEKECELEEEAGRTGPSQQSSGKNEESERREMITPGLRDALTKQGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEMILREAIENHQSLIKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEI
NTFLKLLHRHNISSFLVTNAQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSAS
NLTMANVPWHEEVVHFVRELADLIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWIDYDR
FQELVQEYENSRGSKTFTAADYVAKTPHWAMFGSRERGFDPLDTRFQRKNKTKDISGC
>A0A3B4T7D5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Seriola dumerili|TrEMBL
LCGLLDILCCYSSYKLLMFPKCKIHDIGPWVYKAVKNNDSSDRDTAVHVSGVKIFYGSQT
GTAKAFAKELSEEVKNLGIPAEVTDMKDYDPDDQLADECTSKSVCVFLVATYTDGQPTEN
AEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRV
MTRGEGDCNVVKSRNGSIQADFQAWKVKFLNRLQALAKGEKKSCSGNCKTGGSCKNKRKD
GHMEEEEEEEKDALIESSSDEDESGLQDEKKSGSVVDMEDLGNIMNSAKKAKSKEEGRGD
GQTVKLSKLNGVKKIGDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGR
GGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILRDAVE
KHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSQQISSFLV
TNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTV
YRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFV
QQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQSF
SALDYMAKTPSWALFGACEQGFDPADTRFQRRNKTKDISGC
>A0A3D8R8Y5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus mulundensis|TrEMBL
MAESTAAEGLLTLWHSFRLPLLVALVSVLVIVRLRRVLQARSKTATASSVPPSPRSSSPE
KSTKSVEPVISEKQDSGVPNSGRVSPKPANGPKRVTGRKPLKSAGKRSGSRSGEEEQSVT
HIQPIIFWASLTGSTERYAKVLLEDLRAAAQSQADPENRERGLLPPQIYDLAEVDYEDYF
TTAPKPPSTSPGTRYVYCFLIPSYNIDTILDTFLGHLDETHHDFRIDTGSLSTLAGYAVF
GFGDKEGWPTEEEGFCSQAKELDRWMAKLTNKKRAYPLGFGDVKSDAEASLREWSGGLQD
ILGDIVKNGGLGEGVPGSGDPLESDEELSDDEESDSKSKARRKPQAVVDLEDIKMGADGQ
VAGSPIPVDFTTSGLSSRDYQPTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKS
ALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPDLIF
NGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDLLHSEHI
SSFLVCNAQHPDQLQNLHRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREK
RHIQRTVFRLTLVKGFNIDDEVVGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNV
PFYEEIAAFVVQLNEELLRRGLDYGIAAEHAHSCCVLIASERFRVNGKWHSRIDYPRFFK
LLEKEKAEGTPFRPEDYMRETEEWALWGNGGFDPNDERVFRKGKEAKKALGEKDAATVEV
VA
>J7RK31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3)|TrEMBL
MVSVGISAVLAAAVGVYLYFGGRISIAIVIIVSYAVFCSEQNKQVEDSGDKPSDVPPVVQ
KRKEKHVCACKSGGGGGGGSCCSSKGGKSGGGSCCSSKGAKSGDLSGKKVSIADELEIES
LGEQISEENKKQLEELTIDFTDMFTKEKKSTPKPLSSTKSTKRFTKGKRTLKKEAKQQTV
EFANIADDGLIKSAFTVSNEKLMSSDIYVFYSSLQGASVSAAEKVVKELSSIKELQNSPT
LINLDELDDVDQYFLDVPTEQSFYILVLPSYDVDCPLDYFLQILEETYNDFRVDRYPLRK
LVGYTVLGLGDRESYPEKFCYQAKKADFWLSRLGARRMFPLGEICVKFSGLEKVDKWSRL
LGKMMLDDEPILYEYDETVDNSDDEEEEDNGNVSDEGVVDVEDLTGKTDDDLAKNSTEVK
QMIAKNSPTYKNLTKQGYKIVGSHSGVKVCRWTKNELRGKGSCYKKSLFNIASSRCMELT
PSLACSSKCVFCWRHGTNPVSKNWRWETDDPQFILENALEAHYSMIKQMRGVPGIIADRF
AKAFQVAHCALSLVGEPILYPHITRFIELLHQKHITSFLVCNAQHPESLRTIGKVTQLYV
SIDAPTKGELQKVDRPLYKDFWERMMECLDIIKTVQSHQRTVYRLTLVKGFNMGDIISYA
DLVERGLPCFIEVKGATFSGTAKDSVNALTMQNIPYLEECKKFVESFVALLQSRGLKYEI
AAEHSHSNCVLIAHEKFKIDGEWHTHIDFDKFFEKLESGEPFTYMDYLSKTPEWALYGNG
GFAPGNVRVIRKDKKLENKLLREQQAVTAQGVTSTA
>A2BLU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)|TrEMBL
MSSSTLAEFRPRTVRGKRWKYRIEDFPEPYRTLYRILQKQGYIIIGRHSVYKKCHWTHAA
LVEERFCYKCRFYGIESHRCIQMSPSALWCWNACMHCWRLRPTDTMRWDDTKIPWVDDPD
LIVEGSIEAHREALMGYRGHPRMDERMKKRLEEAMNPAHVAISLTGEPTLYPRLGELIKE
YHKRGLTTFLVTRGIRPDVLANLEEEPTQLYVSLEAWDKKSFNYFNKPLVPRGWELTLKT
LELLPSFSSMTVIRFTLVKSFNMHDEALKAWAKLVEISQPTYIEFKSYMHVGAARQRLSA
SDMAKHLEVFMFAKKFADMTGYRIVSQQIESRVVLLSRLDKPVRVGKGCKEGWEREKVRV
EQLLELLERKKDIDETEYRMVLEQKI
>A0A3B6LTY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum aestivum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRTLRPSPSPXXXXXXXXXXX
XXXXXXXXXXXXKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGA
PPPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALG
AVEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYD
DDDEEEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLEK
QGYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVG
EPIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDR
PLFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVT
YCGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKING
KWHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAA
LKG
>A0A2U4A8Q2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tursiops truncatus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLGLPVALINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKDVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELVQEYEDTGGSRTFSAKDYMARTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A8C2Z9U7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyclopterus lumpus|TrEMBL
MSVWHNRLYLYSAAALVFGIWFSVKVALKKGFAEELSEEVKTLGVPAKVIDIRDYDPDDQ
LADECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLPYAVFGLGN
SVYVGHYNTVGTNVDKWLWMLSAVRIMTRGEGDCDVVKSRHGSIQADFLAWKVKFLIRLQ
ALVKGEKKSYSGNCKTKGSCKNPKKDGQEEEEETTALQNSSEDELVESSSDEEESGLQDE
EKSGSVVDMEDLGNIMSSAKRAKVRLFHVAGEGGLLQAHTTPSLACANKCVFCWRHHTNP
VGTEWRWKMDPAEKILHEAMEKHQGMIRQFRGVPGVQPERYEEGLAVKHCALSLVGEPIM
YPEINAFICLLHSHRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTRDSLKKIDRPLFK
DFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLSYSELIALGQPDFIEVKGVTYCGE
SAASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWI
DYERFQDLVQVQGESGGQRGFSALDYMAKTPSWALFGANEQGFDPTDTRFQRRNKTKDIS
GC
>A0A852N6T9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pteruthius melanotis|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSLGDPTSSEG
TADKLRNGCAPPQAQEVHVAGVKVFYGSQTGTAKRFAKALAEAVSSLNLPVEVINMGDYD
PEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEYRTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKWGRAASSHGVNRSGYQLVYFVCRFLQAKLNCLMIFAL
FSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALAVKHCALSLV
GEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRID
RPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
>K2RKT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrophomina phaseolina (strain MS6)|TrEMBL
MASSDQLQAVSNDLLALWHSSRVPVLLTVCAVIALTRIFQRLRQPREKLSASPVPGSPAS
KVDAIAAPWANTDDIPAFTEKPTQPLHDDHVEDITVAEQPLVRPKPGPKKVTGTKVPRQA
AKRISSFDAVRDKVQPLVFFSSLGGTTEAAAKKLVEELGQWIYALDSESIPRPLEPQIHD
LSYIDYDDYFVSAPKGDQNTKYFYMILLPTYNIDTTLDNFLEHLQETHHDFRIDTAPLSG
ILGYSVFGFGDREGWPTEEEGFCSQGKDVDKWMAKLTGRRRAYPLGIGDVKSDAEQRLKE
WRLGLQEILLDVCAGKGLGEGVPGSGDAVESDEEDIDDGEIDSETPQPSKSRRTKTKSNL
DDVEDLGKMVKSESDPEEPMEVDFTTYKKSTKPMAPSAPKEMVPTSSPTYSSLTKQGYTI
VGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPEKIFEGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFTALLHKERISSFLVCNAQHPAQLATLKQVTQLYVSIDASNKESLRKVDRPLHRD
FWERFCACLDILREKRFQQRTVFRLTLVKGFNMADEIAGYADLVARGLPCFVEIKGVTYC
GTATSAAAGLTMQNVPFYAEVQEFVEALNKELNNRGLEYGIAAEHAHSCCVLLASTRFRK
QVDGQWKWCTLIDYDRFFELLESGEDFKPEDYMGEPTPEWALWGNGGFNPEDERVYRKGK
NKEKNLEASKEVVEI
>A0A0D2MA92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium raimondii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGMVPVGEGDVDGGELESVFEGWSEKVVTVLKGGLVMENE
NGIVYESDVESLESDDDDDGEGGGEDIVDLEDIAGKGPSRKKSVNVAKTNGKLDGKREMV
TPVIRANLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAIDLHTKMIKQTKGVPGVTQERLMEGLS
PRHCALSLVGEPIMYPEINALVDELHRRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAA
TKDSLKAIDRPLFGDFWERFIDSLKALKEKHQRTVYRLTLVKGWNTEDVDAYSKLFVLGK
PDFVEIKGVTYCGSSATSKLTMENVPWHSDVRAFSEALALKSEGEYEVACEHAHSCCVLL
AKTEKFKVNGQWHTWIDYEKFHDLVALGRPFDSEDYMALTPSWAVYGAEEGGFDPDQSRY
KKERHHKSKR
>A0A7K9SMP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Galbula dea|TrEMBL
LDVSMDTWNSFSTCLMSLWLHRFYIYSAVAFGISIWIIIQFTATKTKGKKSTGNPAPSEG
TEDKLVNGYATLQAKEVCVAGVKIFYGSQTGTAKRFARGLAEAVVSLNLPVEVISLGDYD
PDDCLSEETTSRNICVFLVATYTEGQPTESAAWFCKWLEEAANDFRYGKTYLRGLRYAVF
GLGNSVYLDHYNTVGRNIDRWLWMLSASRIMSRAEGDCNVAQSKHGSIEADFEAWKAKFL
SRLQALCRGEKQPCSGKCKKGKCKSAGKRSRESSDHDHGAAEHENAEAEELFETSSEEEA
EAEEAGGTNSVIDVEDLGNIMSHMKKAKLEEGGGGTSLTQETSGREEKDGKREMITPALR
EALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKKDRPEVILQEAIENHQSMIKQFKGVSGVKADRFEEAMTAKHCA
LSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALSEKHQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIE
VK
>A0A086KFW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii GAB2-2007-GAL-DOM2|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKVRGKAKPEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGEYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A1U8QPQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)|TrEMBL
MAESTAAEGLLTLWHSFRLPLLVALATVFVIVRLRRVFQARPKIATASSVPSSPRSSSPE
KTTKSVASSLSEKKDVAVPNGGRVSPKPTAGPKRVTGKKPLKSARKRSSSISDEEKQPVT
HIQPIIFWASLTGSTERYAQVLLEDLRAAAQSQADPENRERGLLPPQIHDLAEVDYDDYF
TTAPKPPPTSPGTRYVYCFLIPSYNIDTILDTFLGHLDETHHDFRIDTGSLSTLAGYAVF
GFGDKEGWPTEEEGFCSQAKELDRWMAKLTNKKRAYPLGFGDVKSNADASLKEWSAGLQD
ILSDIVKNGGLGEGVPGSGDPLESDEELSDDEDSGSGKSKARRKPQSVVDLEDIKMGSNG
QAVGSPIPVDFTTSGASRDVQPTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKS
ALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIF
NGAKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDLLHTEHI
SSFLVCNAQHPDQLQALNRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREK
RHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEVKGVTYCGTSTSAGAGLTMKNV
PFYEEIAEFVVQLNAELERRGLDYGIAAEHAHSCCVLIASSRFRVNGKWHSRIDYPRFFE
LLEKEKADGTSFRPEDYMKETEEWALWGNGGFDPNDERVFKKGKAAKKALKEKEEKEAAE
RAAAAE
>A0A5N7EFS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus pseudocaelatus|TrEMBL
MAELSLTEGLVTIWHSYRIPILIAIASVAIILQAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQTRTDESEKPAVAEKSVTKPASGNDPVPKVVSGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTATTERYAQILLEDLRTAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
NILVDILDNGGLGEGVPGSGDPLESDEEDLDDEENDGNRSKRRNDQDVVDLEDIKMGSDE
QSGSGPVPVDFTTAGKSAAPSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHNEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A0C5BSE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus piranensis|TrEMBL
MSCSGEIIDGEEQLIQIRPAISAQLKKAKYGVSDHSTVELCHWTKKSFKHEGNCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLQTTKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYKSFLKINKPKYDDSWERWNRTLGMLKHLNTRTVL
RITLIRGYNDQKDMIPLFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKQFS
EQITKQSKIFSVMDESFVSRISILQNNERFIDRWIPSYANTS
>A0A7K7CJ66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphelocoma coerulescens|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVVQFTTTRTKRKVTEPKSHGNPA
SSEGTADKLGNGCALPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSFNLPVEVINM
GDYDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLR
YAVFGLGNSAYVDHYNMVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWK
AKFLTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSS
EEEAGGTDSVVDVEDLGNIMGHMKKAKVLLLEGVWNGQVLVTEQVKLNCLMIFALFSGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALSLVGEPIM
YPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFK
DFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLITLGKPDFIEVKGVTYCGE
SSASSLTMANVPWHREVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKFQVDGEWRTWI
DYGRFQELVREHERSGGSRTFSAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDIS
GC
>A0A6J2ELH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zalophus californianus|TrEMBL
MDPLDTWDFSSPLMSLWINRFYVYLGFAFGISLWICFQIVIRKQLFIFKDKNSQKSVPKA
TGDLMKNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKEYD
PDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVF
GLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTKFL
ARLQTLQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGKI
MNYVKKEKREKEQQEEKSSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWQWKMD
QPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLKL
LHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSASSLTMAN
VPWHEEVIHFVCDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQELVQ
EYEDSGGSATFSAKDYVAKTPHWALFGARERGFDPKDTRHQRKNKSKHISGC
>A0A1S8AU93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena saccharevitans|TrEMBL
MSDSATPGADGASVDADDGDGDDGGPAQVSSPDYHSENHTAAQTCGWTANAVRGEGKCYK
NIFYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDDVAWDDPEAVVDASIRLQKKL
LSGFGGNDEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWERLLETMEVLAEKDETRTVLRTTL
VGGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSAMPDHEDVVQFAEQVGEH
MPEFDELKQVPASRVALLAKTGDTWVPKLKKGSEFWERDPVVGD
>A0A7J3M1T1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus fulgidus|TrEMBL
MKQLSELKGYCIVGRHSAVKTCLWLKKSLKDLGVCYKQKFYGIQSHRCLQMTPALLCNQF
CVHCWRPLELLKDFKGWDEPEFIVEESIKAQRKLLSGFYGTEGVNREKLKEAEKPNQVAI
SLVGEPTLYPRLPELVECYKKRGFTTFLVTNGTNPRMIELVEPTQLYVSLTAFDEQSHLE
MNRPAKSLWNRILESLEAMRNSKSRKVIRLTLIKGLNMHEKALEKFDKLIRIAEPDFVEA
KAYMFLGYSRLRLNFENMPSHEDIVEFSKKLEKLGYRIVDESKESRVCLLSL
>A0A8H6LKG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. conglutinans|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8C6W2L0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nannospalax galili|TrEMBL
LGLDVWDLSSPLLLLWVNRFYIYLGCALGATLWICIQITIRKQNLLTNGSLSLQKKPTYV
SGVKIFYGSQTGTAKGFASILAKAVTSLDLPIAVINLKQYDPDDNLVGEITSKTVCVFLV
ATYTDGCPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQSHFNKVGTNVD
KWLWMLGACRMLTRGQGDRNAVQSKHGSIEADFEAWKSKFLSRLQALLQGEKKTCSGECK
RGKCGSIQHGPGEAKPEPQEQGQSHPKEEEPFESSEEEETGFHDLQSLNAVVDVEDLGTI
MNHMKKEKREKQQPEDKTEHVEDKEERAMITPALREALTKQGYQLIGSHSGVKLCRWTKS
MLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVIL
KEAVENHQDMIKQFKGVPGVKAERFEEGLEVKHCALSLVGEPIMYPEINKLLTLLHHRGI
STFLVTNAQFPEEIRNLIPVTQLYISVDASTKDSLRKIDRPLFKDFWQRFLDSLKALATK
QQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASNLTMANVPWHEE
VVRFVRELVDLMPDYEIACEHEHSNCLLVAHKKFKISGEWWTWIDYTRFQELVLQYNKSG
GSETFSALDYVARTPHWALFGAREKGFDPKDTRYQRKNKVKDVSGC
>Q97BF0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)|TrEMBL
MNNLYADIYKKEHYGLVGKHSAVKVCHWTKDELLGGQGCYKNTFYGIKSHQCIQMTPALN
ACTENCAFCWRFQGFDSMHISDEDDPEFILEESIKQHLKLISGFKGNPKVSKEIWEEATH
PKHMAISLTGEPTLYSRLGELIAAAKKRGISTFLVTNGTLPMVLEKLDPLPTQLYVTVAA
PNKQIFNQLLQPSIGNGWENLNKTLELLPSLNTRKVIRHTLVRDVNMPYVEEYAKLDSKG
DPDFIEAKGYVHVGYSISKLSTNNMPPHSEILEFSHSLSEKLGYQFVADRVESRVAMIAK
DPSKAKIDFSNI
>A0A5N1L9F4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. CBA1131|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>A0A1E1INX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania guyanensis|TrEMBL
MMIAFLFQLLVSVGLPLVALLLYNHLADSIHARGSVDVDDVNAFSQRVRAELEQLNVPPA
LPEAAPGQAAPPPAPMRSSPAVTAPPPPEAAEILIAYATQSQNSLALAHKLFSLITAQLH
TAPPSTTDDAVCPLVRVMEMREEEDSSASVAAASAAGGRVSRTNVCRVDTLLEQSQYALI
IFIASTYTNGVAPPRSQAFEALLKDSFEDHRIPRNTLARKRFAVFGLGDIAYGEERFNAF
AKNLHEWCRGLGAPPFVVPPVYTTEAKTQSLFRIFSTALLKWVSRATFHRDGTVTVKKKS
EMGTTGPAAASATGMLSHKAGGITAAPTGETCGSEGASCACQQSTQQQQQQRQPCGNGTG
PDGDDNCGCCKTDSIANCVAASKRDDDDEADDDDEEEEVNGENDGMDDVEDLVWDGTEDT
DFDINKDPSELPELLYPKLRQNLEKQGYRLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYN
INSSQCMEMTPSLACANKCVFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMR
GVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFCELLHQHHISSFMVTNAQFPEQLR
DLKPVVQLYLSIDAPTPEELKRIDRPLFEDYWERCLSCVKELAKKQQRTVFRLTLVNQYN
TENVKAYADLVEMGQPDFIEVKGVTYCGTSTSSTLTMKDNVPRHDEVISFCKALCTEMAS
RHPHYSTLQMNTEEKGGDDGDDDEVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFEG
HWHTWIDYERFYHLVESGRTDFTSLDYAAVTPAWATYNSKEKGFDPEQTRVVRKNARPTV
VTASC
>A0A7L0YNJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ploceus nigricollis|TrEMBL
LDVSMDTWSYFYTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHRNPSSSEG
TSDKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAAHDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDKWLWMLSASRIMTRAEGDSNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEQENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLQGVWNAAGAERREMITPALREALTKQGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEVILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHI
NSFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSAS
SLTMANVPWHGEVLSFAQELARLLPEYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYGR
FQELVREHERSGSSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRRNKARDISGC
>A0A1Z5SYC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii EXF-2000|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRARKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKATANQDAQVIENVQPI
IFYYTLGGSTKVYAESVAQDLAASSPSSILEPQLHDLADTEYDDFFLSIPKAEKTAPFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKNEADGMLKEWTEGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETPALRKTKRKPAKRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINDLLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALAKRG
LDYGIGAEHAHSCCILLADRSRFFRVPAAEKDNPAAEKKWHTLIDYPRFFDCLESGKPFA
PEDYVGAPTPEWALWGNGGFDPRDERVDRKGRPKEPKESKVEEVQEVQEVQE
>A0A256ZGF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcales archaeon ex4484_217_2|TrEMBL
MVRRKRRLKIDFEEAKKDPYRVLFAILRKQKYHIVGHHSAVKKCHWTHAALTEGRFCYKC
KFYGIETHRCVQMSPAVLWCWNACIHCWRLRPQDIGIEWDETRLPTVDDPELIAEGVLRE
QLRILSGYKGNPKVNRKLLEEALKPKHVAISLTGEPLLYPRLSELIQIFHRKGLTTFLVT
RAIRPDVLANLDEEPSQLYVSFEAWNKEMYNKLNVPLAPRLWELSLKTLEILPSFTCPTV
MRITVIKGINMSGKDAEGFAKLVELAQPTYVEVKAYMHVGASTKRLPRSAMPRHGEVRAF
AKLISEKTGYPIVSESIPSRVVLLSKLKKPIRLGKGCPEGWKTPDVGGEESGEYGKYVSE
I
>A0A3N6RSS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica cretica|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLSPSTRRGKIFFISETGTSKSL
AQRLHKLLESNGIAFDLVDPTSYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSGCRFGVFGVGSRAYGEEFNAVAKEMSRRMVGLGGAEMVPLGEGDVDDG
ELDRMFQEWCDGVIRVLKGGSARETNEITQNGVVESEDEYIDTTDEEEEDDNSNDIVDLE
DIAGKAPSRKNGVVKVTKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKGA
LDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRISTF
LVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQR
TVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVKA
FSEALSVKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFTS
RDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>A0A7K7V334|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eudromia elegans|TrEMBL
LDVSMDSQNYFYTCLLSLWLHRFYIYSSVALGIGIWICIQFFTKPRKKDENGNGSPAAAE
VPENKLVNGYVTSKAKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVISLNLSAEVINMGDY
DPDDSLTEETTSRNICVFLVATYTDGQPTETAAWFCKWLEEAVNDFRFGKTYLRGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRTQGDCNVAQSKHGSIEADFEAWKTKF
LSRLQALCKGERKSCSGKCKKGKCKSQGKQSKESLDHEHGTLEYVNTEAEEFFETTSEEE
SDVEKAGDTNSIIDVEDLGKIMSHMKKAKEGGDRAGWSRESAGRKDEGEKREMITAALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCAL
SLVGEPIMYPEINRFLKLLHQQNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLMALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEV
KGVTYCGESAASNLTMANVPWHEEVVHFVQELADLLPDYEVACEHEHSNCLLLAHRKFKI
DGEWCTWIDYDRFQELARDYERSGGAKTFTAADYVAKTPHWALFGSRERGFDPLDIRYQR
KNKTKDVSGC
>A0A8C9MM58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Serinus canaria|TrEMBL
MRLFCVCSFHVHSVGTCDIPDLDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVI
QFTTTRDKRKGEQSQESPSSPEGTSDKLGNGCAPRQAQGIHVAGVKIFYGSQTGTAKTSS
RNICVFLVATYTEGQPPESAVWFCRWLEEAANDFRVGKNFLQGLRYAVFGLGNSVYVDHY
NTVGRRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTRLQALRRGEK
KPCRGKCKKGKCKSSGKQSKESSDREHGTSEQDNTEAEELFETSSEEEAGSPDSVIDVED
LGNIMGHMKKAKREQELQEGAAGAERREMITPALRKALTKQGYKLIGSHSGVKLCRWTKS
MLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTKWLWRMDQPEEIL
QEALEKHRNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINHLVRLLHQQGI
STFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLESLKALAEK
QQRTVYRLTLVKAWNVDELRAYADLISLGKPDFIEVKGVTYCGESSASNLTMANVPWHGE
VLSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYSRFQELVRERERSG
GSRTFTAAEYMARTPPWALFGAKERGFDPLDVRFQRKNKARDTSGS
>A0A2C5YAT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps australis|TrEMBL
MEASFWTRRMGLVFSLDDLVALWHTHRTLLILCAFAVLVFIRAYLHLRGDREGLCVLPAK
FEQHGLPDKAAKSSGPRRIRGGIVKKTSRNGNEETELTRLNGDEKTNSTRPVAVMVFFSS
VTTKTETIAREYLATLKEAVTQLAKDSGRQFLEPELHDLSEIDFEDFFVAPPKSEANAQF
FYLFLIPSYNIDTINDTLLQHMEETHHDFRIDTAPLAPLIGYSVFGFGDREGWPDEANGF
CFQAKHLDKYMSKLTGRKRAYPIGMGDMKSDHGLRFSEWAGGIHDVLGHVARTDSLGEGV
PGSGDAEESDEGDAADEDDGEALLDVDQEGQTSTNSSRPLDDVEDLGKMMRSTDGETRPL
AVDFTDYGRPSTSSSTRPKATKSKTTAQPGPLVVKEMVAKNSPTYAALTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDAPDLIFEGVKEQHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPHINE
FLALLHGERISSFLVCNAQHPDELAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERF
QRCLDILREKRFRHRTVFRLTLVKGFNVDDEAEGYAALVERGLPCFVEIKGVTYCGTSTS
SNAGLSMSNVPFYWEVCDFARALETRLRARGLAYGIAAEHAHSCCILLASERFRVGGKWR
THIDYGRFFELLEQRGADGEWRPEDYMGQETPEWALWGNGGFDPRDQRVDRKGRRIENVV
VREQPPGEVW
>A0A672IHP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarias fasciatus|TrEMBL
MVLKKQNLSSEDVSFISKVERNSHQPHKEIEVHVSGVKIFYGSQTGTAKGFAQQLCQEVK
ALGLPAEVIDMKDYDPDDQLADECVSKTVCVFLVATYTDGRPTENAEWFCKWLEEASTDF
RYGKTYLEGLRYAVFGLGDSVYVGHYNTVRIRVSRHRSVINLSELHGERLVNRFTSIPPG
GEECGQVAVDAQRRAHHDQRRGRLQRGEEPQRQRPGGLPLLEGQVPQPSAGSGERREEEL
QRELQDWRLLQEQEERRGSSSDEDESGLQERNNYSTLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAHKILEDAVEKHQ
GMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHQQHISSFLVTNA
QFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLASLRALGEKRQRTVYRL
TLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQL
ADMLPQYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYQRFQELVEAHEESGGQRSFSAS
DYMAKTPSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A8D0TZP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMGRVKKEKREKAQQEGETGVLRSAVKNEASEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSVDPPMRLPEQPGAGKPENEEKGGRGAPGGGEEPPRSR
APDFPTWQVFSPKPLPEKQAFSNVYSGLDCFQPAGRGWCGGREPLCQMSGRWGEGEETPW
TRRPGRGPPGMHIPLGQRFGDLS
>A0A662S8K7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MAGGIVRVPQHVRELMEKQGYKFVLNHSAIKPCYWFREALMRGRTCYKNKFFGIATWSCL
QMTPAASFCNLQCLYCWRLNASDMPPDFRWKEIPDEGAKWDDPEDIAEESIRIHRMLVQG
YKGVKVFSERWLREAEVPRHAAISLTGEPMLYPHIGGLVDEYRNRGMTTFIVTNGTLPER
LESLEREPTQLYVTVPAYEEGLYKRITRPLIPDAWQRLNRTLELIQSLSAPTVMRITAIK
GLNMNKPEEWAKLIEKYEPTYVEPKAYMYVGYSRRRLSRENMPSHAEVREFAEALAEKTG
YRILSEVPESRVVLLSKLEKPIRFDGR
>A0A662SMQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MPKRVTVQEYPKRMLEKQGYKIVLNHSAIKPCYWFREAIMKGRTCYKHKFYGIPTWRCLQ
MTPTASFCNSQCIYCWRLNASDVPPRFRWKEVPDPDEEWDDPEEIAEESIRLHRLLVQGY
KGVKVFDREWLYEAEIPAHAAISLTGEPTLYPYLGELVAAYKKRRMTTFIVTNGTLPERL
ENLSTEPSQLYITVPAWEENLYKRVTRPLWPDAWQRLLKSLDLLQSFSCPTVMRITLVKG
LNMSNPEGYAKLVNKYNPTYVEPKSYTYVGYSRRRLPRDASPSHAEIKEFAERLADKTGY
KILSEAPESGIVLLSRLDKPIRLSPVR
>A0A3R7DQQ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVLPEELLRTYRRQRYQLAGTHSAVKTCHWTRESLRTGERRFCYKQKFYGIRTLRCLQMT
PSLGRCLQRCLFCWRATPSDLGVDWDQTRFEEGEAEDPAYIVEQSIEAHRRAISGFKGNP
RVDPRLVELAMNPVHAAVSLEGEPTLYPYIGDLIGEFFRHGFKTVFLVTNGLRPDVLADL
SHEPSQLYVSVSAPDEETYKRVCRPLVPDGWRRLNETLELLESFEAPTVLRHTLVRGLNL
KDPEGYARLIAKANPTYVEPKAAMAVGFYRMRLTYEDMPTHQEIRAFAEALARETGYHIL
DESEPSEIVLLSRLKRPRRFE
>A0A7J2N302|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKVIEEMKKIYMKQGYHFIGKYALIKPCHWLRRSLITKGIQHCYKQKFYGIPSHRCLQLS
PTIACTQRCLYCWRVQAADLGLVWNDYVIKDYDNPEDIVLNGILMQRQILSGFKGNPKVN
AEILEEAFRPIHAAISLVGEPTLYPRIGELIAAFFRHGFKTTFLVTNGTLPEALSNIECE
PSQLYVSLSAPNENIYRKLCRPKISDGWKRLKESLEILGSFSCPTVIRITLVKGWNMQNP
EEYAKIIDKAEPTYVEVKAAMSLGGSRLRLPIESMPKHEEVKAFGMKIGEAASYNLIDEA
VESRIILLSKLEKPIKLI
>A0A7K3ZM11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MEETAASPLLAALKKQKYHLIGAHSAVKRCKWLYESIVNNRPCYKQKFYGIQSHRCMQMS
PSLYYCTQQCLFCWRAQSGDMDARWNEMHNPNKDTPEQIVEGCFKAQEKIISGYKGNEKT
DWKKFQEAHRPSQVAISLTGEPTLYEPLGDLIKLFRQKGLTTFLVTNGTLPSRLSRLSQE
PSQLYVSLCAPNEEVYNRVCRPNFPAAWSKLNETLEMLKSFRCPTAVRMTMVKSHNMELV
SQYAKLVEKGNPTYIEAKAYMHIGFSSLRLGFNSMPMHHEVREFADKLAAETGYRVVNEA
PESRVVLLSKLEKPIQLGSN
>A0A497F8A4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MAIPKQIIDVYKRQGYHFVGKTSVVKPCHWLKASLLTKGEKFCYKQKFYGIPSHRCLQMS
PTLACTQQCLYCWRVQASDLNLSWDEMSLMDYDEPEEIIVKAILKQRQILSGLKSNKLVD
RKMLEEAFRPIHAAISLVGEPTLYPKIGELIGSFFSHGFKTVFLVTNGTNPKVLSNLEYE
PSQLYVSLSAPDEETYRKVCRPRIKDGWERLNETLELLKSFSCPTVIRVTLVKQLNMHSP
EKYAKLICKAEPTYVEPKAAMSLGWFRYRLPLDAMPRFEEVKEFGEQLSRYTGYKMIDFS
VNSRIILLSKLDKPIKLV
>A0A497JYC3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKENSSSKDSLPEYQRILYRQGYRIVGRHLHSAVKICQWTKESLRNNRVCYKELWYPPVE
SHRCMMMTPYLGCNLHCLHCWRLHSGDRPGLVWKEFPLEIEELDEPAEIIDEAIEQRKQL
LSGWKGNPKVDRKKFEEALKPTMMTMSLTGEPTLYPRLSEMIEEAEKRGMITFLVTNGTV
PESLENMDKLPFQLYVSILSTNRKDYIRLARPLIRDAWERLNRTLELLPSLDTRRVLRLT
MIKGYNMNDHDGYAKIVEKAQPDFVEVKAYEWVGESRRRLPREAMPYMSDIEEFANKLSS
LTGYEIKGKYKPSGAVLLVK
>A0A075FZZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine group II/III euryarchaeote AD1000_87_G01|TrEMBL
MQNPITRIEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLVNDRSCYKGTFYGIESHGCM
QMAPNVDTCNLACTYCWREPHSETLHKIDDDPYELFLESVRGHRRLITGYGGNPKADPEK
FREAQNPKHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDPLPTQL
YVSVDAPNKEVFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDY
ARLDNIADPDFIEAKGYVYVGNSRNNLTIENMPSHDDVMGFSRRLAPLVGREVLSDRSES
RVALIGREMVPITLPEKVRELPKDLGIAKPQRYMLPQA
>A0A8B8DRL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crassostrea virginica|TrEMBL
MLEVLLSSHLAVVYTLLLGVVCLIWVFYGRKTSKQHSEKEQNFKSKSTESPVTNVKSKEN
GKLCGQKENSSCGRNKKIKILYGTQTGKSKYFADNLSKDANYKGYQCEVVDLQNYDPDES
LSNESNNAVCLVIFISTYTEGTAPKGAEWFVQWLEESASDFRVQKSLLSNLHYAVFGLGN
SLYEEHFNTVGKHVDHYLHKLSGHRILPVGLGDENVSQSHKGVENDYVAWKREFWKKLKN
KASVSAPKGNEKTCENGGQCTCEEKDDVIDSNSSESESDNDESTEDVTGDDIVDVEDIGR
VMGSKKQATKVESSNKELSEMITPIIKKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDDAEFVFNGALQNHV
SLIKQFKGVPGVQPERFLEGLTPKHCALSLVGEPIMYPKINKFIELLHDKEISTFMVTNA
QFPDAIRDLSPVTQLYVSVDASTKDSLKKIDRPLFRDFWERFISSLDALSAKCQRTVYRL
TLVKAWNTDELDNYASLVSRGKPDFIEIKGVTYCGESKASSLTMENVPWHTEVVNFVQEL
VDRLDGNYEIAAEHEHSNCVLVANKKFFIDGKWWTWIDYPKFHSLIKQYRESDGKKTFSS
DDYMAQTPDWAVFGAEERGFDPKEVRHFRKKKDF
>A0A091LYS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cariama cristata|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYFAVVFGISIWIMIQFTTTKTKKKGEKSNGNPTSE
GAEDKLVNGYTTLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLSLPVEVISMGDY
DPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVNDFRFGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKVKF
LSRLQALCRGEKKPCDGKCKKGKCKSPGKQSKESSDHQRGASEYRNTEAELFETSSEEEA
DAAEAGGTNSVVDVEDLGNIMSHMKKAKGEHELKEGDVGTSLTRENAGRKEEGEKREMIT
PALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKADRFEEAMTA
KHCALSLVGEPIMYPEINRFVKLLHQNSISSFLVTNAQFPDEIR
>A0A7K7EG18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sylvia atricapilla|TrEMBL
LDVSMDTWSYFHTCLASIWLHRFYIYSAVAFGISLWIVFQFTTTRTKRKVTEPGTTDKLR
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVASLNLPVEVINMGDYDPEDGLV
EETTSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDYYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTRLQVL
CKGERKPCSGKCKKGKCKSSGKQSKESSDLEHGTSEHENTEAEELFESSSEEEAGGTDSV
IDVEDLGNIMGHMKKAKVLLFGGSWCQSVWVPLGIFVCQFLQTKLNCLMICVLFSGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYP
HINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDF
WQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDFVEVKGVTYCGESS
ASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCLLMAHSKFQVEGEWRTWIDY
SRFQELVREYEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKHKARDISGC
>A0A2E9CBF6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELVDQDPLEMLYESVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEETIDLLPSLDTRVVCRHTLIKGKNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRVLAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMHFPDDLGIAESIKHLKIVQ
>A0A2D8F7D7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLTGYGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYTRLAEYMDLCHQHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAAIDR
RADPDWIEAKGYVYVGHSREHLSIDNMPAHEDILAFSESLAPQVDMRILSESRPSRVALI
GNEMIPIPIPEATMHFPEDLGTAPPVKKLKLADLS
>A0A2E1GGA8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDKLCKPKFDQGAFHKLEETLELLPSLDTRTVCRHTLIKHESMGYHEDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHKEILEFSEKLAPMVGREVLSDRRESRVALIGK
EMIPVELPIAIRELPKDLGIAKPQRFLLPQA
>A0A7J2J545|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MQRELLLRQGYKLVGKAGGVKLCHWTKESLRGDRYCYKQKFYGIESHRCIQMTPSVFHCN
LNCLFCWRYNNYPYVEMKEWDDPSYLLEKSIEAQRALISGFGGNPKVNKEKFEEAMEPKH
IAISLAGEPTLYPELGEFIEEAHRKGFTTFLVTNGTNPKALEELDPLPTQLYVSVTAPNE
RVFEALNLPRVPRAWESLIETLRLLPSLGTRRVIRHTLVKGWNMPFVEDYVKLDSIAEPD
FIEPKAYMNLGYSRYRLNPGNMPKHWEILKFSEELSKELGYHIVSESKESRVVLISKRKS
GIKIAQ
>A0A534J2G3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPAKREVLERQGYKVVGEHSGVKVCHWTKSSLTKGVGCYKETFYGIKSHRCLQMTPAVD
SCNLGCLFCWRTQEWGSDSLVHADDPGFIVEESIEAQRALLTGFKGNPKVSREKFDEAWH
PNQVAISLTGEPTLYRRLGEMIDEFHRRKMTTFLVTNGTTPAVLRRMASEGRLPTQLYVT
VAAPNADVYRKLMAPKSEHEWEKLKETLALLPTLDTRTVIRHTLVEGWNLGWEDEYAALD
GIARPMFIECKGYSFVGESRLRLRVENMPEHATIREFAGHLGDRLGYKIASEREDSRVVL
LTGDGELHPIQS
>A0A2E0MWT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGDHGGVKICHWTKESLLRDRQCYKGRFYGVASHNCMQMSPVVD
QCNXAXSYCWREPHMDSLELSDQDPLEMLYDSVKAQRRLLSGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYNRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNSAAWDKFEETIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILXFSXXLAPLTXRKLLDDSPPSRVALV
GKXIXPIPIPEATMQFPEDLGIAKSIKHLKIVQ
>A0A2Z2I1N9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrarchaeobaculum aegyptiacum|TrEMBL
MSDSADGGRQAGPAVDEGGDAGRSGIDGSETGETGADDDGGGPAQVSSPNYHNENHTAAQ
TCGWTANALRGEGKCYKNIWYGIESHRCIQMTPVVRCNERCVFCWRDHNGHAYELDGVEW
DDPEAVVDASIRLQKKLLSGFGGNEEVPREVFEQAMEPRHVAISLDGEPSLYPYLPELIE
AFHDRDITTFLVSNGTRPEVLRECDPTQLYVSVDAPDRHTFDEVVGAMEDDAWEKLLETM
AVLREKSETRTVLRTTLVKGENMHHPDWYAGFYEQADPDFVEIKAYMHVGHSRGRLDRSA
MPHHDEVVEFAEDVMEYMPEFTECLEVPASHVALLSKTLDTWVPKLKKGSDFWARDPVVG
D
>G1MIL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ailuropoda melanoleuca|TrEMBL
MDPSLDTWDFSSPLMSLWINRFYVYLGFAFGISLWICFQIVIRKQLFIFKDKNSREKSVP
KATQDLMTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFAASLAEAAASLDLPVAVINLKE
YDPDDHLLEEVTSKNICAFVVATYTDGRPTESAEWFCQWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTK
FLARLQTLQKGEKKPCDGNCKRGQCESSTEEEPFESTSEEESGTEDHQNPNSVVDVEDLG
KIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQEL
MQEYEDSGGSATFSAKDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A2D5KIH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPEIAARLAKQRYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLTKIDDDPYELFLESVRAHRRLLTGYGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLEICHQHGVSTFLVTNGSLPKVIEELDPLPTQLYVSVDAP
NKEIFNRLCKPKFDTAAFEKLEETLQLLPSLDTRTVCRHTLIKGESLGHYEDYARLDNIA
DPDFIEAKGYVYVGNSRSNHTIENMPSHDEIMEFSRTLAPMVGRDVLSDRRESRVALIGK
EMIPVVLPEKVRELPADLGIAKPQKFTLPIA
>A0A8C4EU57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
VGQTGSDKMISLSEEVKASGIPAEVIDMKDYDPDDQLADECTNKAVCVFLVATYTDGQPT
ENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGM
RIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRLQALAKGEKKTCSGNCKTGGSCKNKR
KEGHDSDEEESGLQDEKKSGSVVDMEDLGNIMSRLCWFTTKRKCNLHFSVCSSSAEFGLY
GTGSKKCLLSDSLILLTSCYFSFCAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAETILQDALEKHQNMIRQFRG
VPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKSWNV
EEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLTDMLPQYE
IACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPS
WALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A1R3RLJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus carbonarius (strain ITEM 5010)|TrEMBL
MAETSAAEGLLAFWHSYRLPLLLALATAIVLLRAYRKVQPKSKIATASSIPSSPRSHSPE
TSEKIASNHNEQKIEKASTTQVVEKEFVAEKVSAKPGPKRVTGKKPAKVAGRRRGSDQEP
AVSFIQPIIFFASLTGNTERYAQVLLEDLRAAARDRADPENREQALLPPQIHDLSYVDFD
DYFIAAPKPPSTSPGTRYVYCMLVPTYNIDTVLNTFLGHLDETHNDFRIDTAPLAGLAGY
SVFGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFADVKSDPEAALKEWTSG
LKDILGDIVDNGGLGEGVPGSGDALESDEEDLDDESDSKANGRKRNKAQSVVDLEDIKFS
SETGSSAPVPVDFTTGGQQSAPATEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELI
FNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQN
VPFYEEVQQFVTSLNKELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFF
QLLEKEKADGTSFTPEDYMKETEEWAMWGNGGFDPNDERVYKKGSKKKAIQAAAEAQG
>A0A4U0XWU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Friedmanniomyces simplex|TrEMBL
MDFLQLPSELLHLWHTHRTEILLSAGLLFAIVRLAVHWRTRRSREALTPPVLSPVHEKSL
PPLEQQLVETDPYTDLSVPRPPRPKAGPKRVTGNKKAKAISTIKEPAIDTIQPVIFYYTL
GGTTKTYAEQLASALPSPSQQILIPECLDLAQIDYDDYFISPPKPPNANTAFLSNFLAHL
RETHHDFRIDTAPLAGLAGYAVFGFGDKRQWNTEGEGYCKDAVDVDKWMARLTGGKRGFP
LGQGDTSGRGNVEMRVREWTEGLTGIMAALARGEGLGEGVKGSGEAVESADEKEDEEDSG
TLELEDGRAAAIKSKRKPNRRSRTDDLEDLKAPIPVDFTTSRPGSTTVPPPPKAMVPVNS
PTYTSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSN
KCVFCWRHGTNPVGTTWRWTVDPPDLVFAGMKEGHYKKIKMMRGVPGVRAERFAEAMQIR
HCALSLVGEPIFYPHINELLAMLHKEHISSFLVCNAQHPDQLATLGPVTQLYVSIDASNK
DSLRRIDRPLHRDFWERFIRCMDIIRAKRFTHRTVFRLTLVKGFNIDEEAEGYADLVARA
LPAFVEVKGVTYCGTSTAAGAGLSMGNVPFYEEVQAFVLSLEAALQRRGLDYGIAAEHAH
SCCILLADRERFYKPSRGDEDGGRKWHTLIDYAAFFRCLKSGNAFGPEDYVGAPTPEWAL
WGRGGFDPRDERVDRKGKPRVVEVVQ
>A0A8J7RE79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofollis sp. W23|TrEMBL
MRSRRCDDGSPRGALKKQGYQFFSPESTAAVKPCLWNKRALRGGEMCYKHQFYGISSHRC
VQMTPTLKCNQRCLFCWRSFEYEVEETEEYPPEEIVANLRRLQKRALSGYKVSPYVTQER
FKEALEPDMVAISLSGEPTCYSRLPELIDLLNAEGYTTFLVSNGTHPEMIRRCHPYQTYI
SLDAPDRETYLGLCNPVEDFWDKIQESLGELASRRSAIRTTIVKGINDIDPAGYAAIYDA
ARPTYIEIKGYMYLGYSRNRLSREHMPEHAEVRRFAEAVAEHCEYEITDESPISRVVLLE
RVE
>A0A2Z2M508|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus gorgonarius|TrEMBL
MAIVVRSNPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTRGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQFYVSLTAPDLETYNRVNVPMIPDGWDRIKETLKLMKDAQTRTVIRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSNGRGLNGRFIKD
>A0A2R6T7K6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon SCG-AAA382B04|TrEMBL
MIPQEVQEILENQKYKIIGENGAVKLCPWLKEGMQDNKGCYKQRFYGIKSHRCLQMTPSV
SHCTQKCLFCWRAYEAWHKNKIDTYSSPEELLDQAIEAQKQLLTGFGGSLDKYEEKLWEE
SKKPKHVAISLSGEPTLYPEISGLIKEVHDRDMTSFLVTNGTQPNKLKNLEQNPTQLYIS
LDASNKETYQKLCRPQIDDAWENLQESLKYMSNLDTRTVLRITLVEDVNSELNKEYLDLI
EKANPDFIEVKAYMHIGYSRKRLERQNMPSNRKIQNFSQKISNKTNYKLHDNVKKSRVSL
LTKKDPEIKGLYQ
>A0A2G9PRU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG08_land_8_20_14_0_20_59_11|TrEMBL
MATCAIPQNFIDKYERQQYSLVGEHKHSAVKICSWTKRALLGSGSCYKQKFYGIQSHRCL
QMTPSLFWCTFRCLHCWRSIEANLGFDMSSAVLDDPEKILDGAVAAQRKLLIGFKGNEKA
NAEKWREAQNPNQVAISLAGEPTLYPKLSGLIRCARRRGMTTFLVTNGTQPGALLTLKEQ
DALPTQLYVSLCAFDKESYARVHQPVIDDGLERLLETLRIYPALPTRRVIRLTLSKGLNF
SNPKKYAALIKQADPDWVEAKSYMAVGYSRNRLGPKYMIPHEEIREFSEELARHSGYEIT
DEQKESRVVLLSRDAQAAANRFITQND
>A0A510BCQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofervidicoccus sp. A16|TrEMBL
MTTYNNPYIPEEIYKILRKQRYQIKDHSAVKLCGWVKKSLLENKNCYKSKFYGIETHRCI
QCTPSVIWCQQSCIFCWRVLPSDIGTSQLSHHNVKWKEPKEVLEDILKMHRKVVMGYKGI
LDRIGKERFKELLDPKHVAISLSGEPTLYPYLDELIDLFHRRGFSTFVVSNGILTEVIQE
IKPTQLYISVDAYDLESYKRICRGREEYWQSILDTLDTLRSKERTCIRTTLIRDYNTNIE
KFIPLYERADVHFIELKSYMNVGYSRRRLTLDHMLKHEEILELGRRVEELSHYKVADDSY
DSRVVLLVNEDRKVERFIGGENK
>A0A6P5M2Y4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phascolarctos cinereus|TrEMBL
MDASLDAWDHFYTPLISLWVNRFYVYVGLAFGVSLCICVQVVTKKLGDRSTGKSSLQKLP
SSHGSCGPLAPVASGPTSHQKKEVHVSGVKIFYASQTGTAKGFATSLAKRVTALDLPVAV
INLKEYDPDDHLGEEVTSKSICVFLVATXADGRPPDSAEWFCKWLEEASNDFRFGKTYLK
GMRYAVFGLGNSVYESNFNKVGKNIDRWLWMLSARRVMTCGEGDGNVVRSRHGSLEADFA
AWQARFLSRLQDLSRGSTGEKKACRSSHRRGSCEKGGCRVKKKGKGMGASGAPPEAPKEK
EQFETTSEEESGAEEGQSRSSVMDVEDLGKMMSSMKKAKKEKEQQDMELDLSWDTGKNEA
QEKREMITPALREALSKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPDMILQEAVENHQNMIKQFKGVPGVKAS
RLEEGLQVKHCALSLVGEPIMYPEINRFLKLLHQRRISSFLVTNAQFPTEIRNLEPVTQL
YVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALATKQQRTVYRLTLVKAWNVEELQAYV
ELVSLGEPDFVEVKGVTYCGESSASNLTMANVPWHEEVIRFVEELVDLLPNYEIACEHEH
SNCLLIAHTKFKIDGEWWTWIDYDRFQDLIQEYETSHGSKTFSAKDYVAKTPHWAVFGAS
ERGFDPKDTRFQRKNRSKDISGC
>A0A319DNL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus ellipticus CBS 707.79|TrEMBL
MADTPVSEGPLAFWHLYRLPLLVALATTFVLVRAYRKLQPKAKIATASSIPSSPRSQSPE
KSEKIAIGYDGKTPEKEVNTEVAEKEPTKSAGPKRVSGKKPLKVARRAGSDQEPPISFIQ
PIVFFASLTANTERYAQVLLEDLRAAARDQADPENRERGLLPPQIHDLSYVDFDDYFINA
PKPPPTSPGTRYVYCMLIPTYNIDTVLNTFLAHLDETHNDFRIDTAPLSGLAGYSVFGFG
DREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSLGLQEILG
EIVSNGGLGEGVPGSGDALESDEEVSDDEGSDSKAKGRKKNKAQGVVDLEDIKFSAEKGS
GSPLPVDFTTGGKPSVPAPEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRG
RGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVK
EGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFL
VCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHIQ
RTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPFYE
EIQQFVTSLNKELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEQ
EKADGTPFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKTIEAAEEVQD
>A0A420YM85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coniochaeta pulveracea|TrEMBL
MQVMASEPVGLGQILAGLESEDVVQLWHSYRMPILLSILAVLLSLRLYLRLTDKKEDLKA
IPKIYEPPVEKQVPNVRSTSPATTAKPKTQAPRRIKGELGRKSSQDSVNGPREIQVYLFF
SSLTATTDKIAHDYGKKLEESLKATTEDKVHFLPPKVLDLAEADYDEYLITAPKVPTRNG
EGQAELFYLFLIPSYNIDSINDNLLEHLKETHHDFRIDTTSLSGILGYSVFGFGSREGWP
TEEEGYCFQAKEVDRWMAKLTGRKRAFPLGMGDVKGDGMKRLDEWNEGVLDVLGLLARTG
SLGEGVVGSGAPDESDDEAEVDDDDGEVILGDGETQVLKKKSIDDVEDLGAIMKSSRPDG
ETPAPIAVDFTTYGKEKKRTPVVTVKEMVPKNSPTYNSLTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTSWRWVVDPPDLI
FAGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHSER
ISSFLVCNAQHPDQLAALGHVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRFKQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEIKGVTYCGTSTSSNAGLTMGN
VPFYHEVCDFVEALNKALAKRGLKYGIAAEHAHSCCILIASERFNVDGKWHTLIDYGKFF
NLLEEKGPDGDFTPEDYMGAATPEWATWGNGGFDPRDQRVDRKGRVIEI
>A0A1E1LZJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhynchosporium secalis|TrEMBL
MAYNSLVLRPLLPFEITDIVALWHSYRIPIILTAVITLFIFRTYLHLRFPRHKLTGTPPI
SPSLPALKEKPLPAEKKPPAEKVPRRIVGGLKKRKSSQEEIKPTAQKIQVLVFFSSLTGT
TEKTAKVFTESLAQNTKKLGATTSATFLEPEILDLSYIDYDEYFINPPKSDSGAQYFYLL
LLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLSGYSVFGFGDREGWPTEEEGFCSQA
REVDKWMAKLTGRKRAFPLGMGDSKKDAADRLAEWKEGVEDMLAHIAATGNLGEGVVGSG
DAVESDVEDLDDDEDVLFDEQNVAIRKTKTKKKEALNDLEDIGSTLNKTEAAEDDDDDDE
ELELDFTTYSKKPVTKTAVAVIKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFDG
VKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISS
FLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILKERRF
EQRTVFRLTLVKGFNIEDEAEGYAALVAKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPF
YEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILLASERFRVEGKWHTRIDYEKFFKCL
ESGEEFRPEDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTERQGEVMEI
>A0A7K7H2N0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erithacus rubecula|TrEMBL
DVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTRTKRKVTEPKSHGNPSSS
EGTAEKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLHLPVEVINMGD
YDPEDGLSEETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYA
VFGLGNSAYADHYNTVGRRMDRWLWMLSGSRIMTRAEGDCNVAQSKHGSIEADFEAWKGK
FLTRLQVLCRGEKKPCSGKCKKGKCKSSGKQSKESSDNEHGTSEHESTEAEELFETSSEE
EAGGTDSVIDVEDLGNIMGHMKKAKVLLLEGIWNVHGVSHSGYHLAYFVCQFLQAKLNCL
MNCALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDPPELVLQEAMEKHQNMIRQFKGVAGVKAARLEEALAVKHC
ALSLVGEPIMYPHINSLLRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKES
LRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISIGKPDFI
EVKGVTYCGESSASSLSMANVPWHGEVQSFAQELARLLPDYGIACEHQHSNCLLLAHCKF
QVDGEWRTWIDYGRFQELVREHEQSGGSRTFTAAEYTARTPAWALFGAKEQGFDPQELRF
HRKSKAQHISGC
>A0A3B4H5I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pundamilia nyererei|TrEMBL
MPTFIVFVLLLASSVSASDSKVSQDARSLTESYFMWLWHSRLYLYSAAALVFGLWFLLKK
KSVSKDASKEKNDKVDKAAKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKSLG
LPAEVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSI
QADFLTWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKASPQNNSSEDD
LVESSSDEDESGLPDEKKTVLDVEDLGNIMNSVKKAKSKEESQRDGQMVKLSKLNGVQKI
EDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGV
KPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPV
TQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQ
AYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACE
HEHSNCLLIAHTKFKMDGEWWTWIDYERFQELIQAYDESGGQQTFSALDYVAKTPSWALF
GAQEQGFDPAETRFQRRNKSKDISGC
>A0A8J5BVK5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Yarrowia sp. E02|TrEMBL
MFDEILDLWHGSRLMLIPIIGLVIFIVLFDEKKPAEAETKVSDKSTAPSKTSSRALDEKP
PMAVDFTTSSSSSATASKPKRVPKTFGKGPKKLSVSLASQVYVFYSTLTGSTERYAQQLF
EYLSTKTTKEPILLNVDYIDDLDEYFVNSKAGSVYCFIVPSYETESPLDYFLDTIKETYN
DFRIDSRPLSKICFTVFGVGDKESWPEKFCYQAKEVDRGLAKLGARRLNPLGNGCVKTDF
ETNMMEWREHFVDALADGVVPEADDICSDDEEEEEEGTKDGIVDVEDMGKIIGSSKPKRK
SAKEIMEADSCSAKEMVAKDSPTYKALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKF
AFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPKEILDGALAGHYQKI
KMLRGVPGVSAERFAEAFRVKHCALSLVGEPIFYPHINEFVGMLHEKRISSFLVCNAQHP
KELAAMNQVTQLYVSIDAATKESLKAVDRPLNRDFWERLQECLSILREKRNQRTVFRLTL
VKGFNAEEVENYAKMVAKAMPCFIEVKGMTYCGTSKGNPLTMKNVPYYHEVLDFVEQLNE
AVANEGLEYGIAAEHAHSCCVLIAQKRFYIDGEWHTHINYDKFFDMLEAGQEFGPEDYTS
ATPYWAQYGAEEAGFNPADVRHRRGKVVEV
>A0A811Z6U6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nyctereutes procyonoides|TrEMBL
MNPFLDTWDFSSPVISLWINRFYIYLGFAFGISLWICFQIVLRKQLFILKGKKSQENSVP
KATGDLMTNGCISLQNKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKE
YDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FLARLQTLQKGEKKPCDGNCKRGQCESSMEEEPSESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSERRTMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLRPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKIGREWWTWIDYNRFQEL
VQGYEDSGGSATFSAEDYMAKTPHWALFGAGERGFDPKDTRYQRKNKSKDISGC
>A0A0P7ZEV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedens sp. BLZ1|TrEMBL
MNSIPETTQSLLKKHGYHLAGTHSAVKTCLWLNKSIRNTGACYKSKFYGMTSHRCIQMTP
TLVCNHRCLHCWRAVEVPVQVPHVWDTPEEIVKAVFNEHKRLISGYGGSEFMDKTRWKEA
FSPKHVAISLSGEPTMYPHLPELIEEFHKNDMTTFVVTNGTIPDMVEKIKPTQLYISLNA
PDENTYEKACSPIGNSWENIKQSLEILKRSGTRTAIRITLTKGVNMVDPEGYARLIELAR
PDYVELKAYMHLGFSRKRLSQDNMPSHEEVLGFSRQVAEVLEYSIADDSGGSRVVLLSKD
GGKHNI
>Q9HIQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)|TrEMBL
MQNIYADIYRKEHYGLVGRHSAVKVCHWTKDELLGGPGCYKNTFYGIKSHQCIQMTPALN
ACTENCAFCWRFQGFDSMHISDEDDPEFILEESIKQHLKLISGFKGNPKVSKEIWEEATH
PKHMAISLTGEPTLYTRLGELIAAAKKRGISTFLVTNGTLPSVLERLDPLPTQLYVTVAA
PNKKIFNDLLNPSIGNGWENLMRTLELLPSLDTRIVIRHTLVHGVNMPYLDEYAALDRKA
DPDFIESKGYVHVGSSMTKLQASHMPSHAEILEFSNDLANRLGYTFVADRVESRVAMIAK
DPSKAKIDFNNI
>A0A662VM83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobales archaeon|TrEMBL
MDITISKKLLKDLKGYQIVGRHSAVKTCLWLKKSLKDRGVCYKQKFYGIKSHRCLQMTPA
LMCNQSCIYCWRPLELLDKLEGWDEPEFIVEESIKAQHRLLSGFHGTPNVNKKKLEEAYK
PNQVAISLIGEPTLYPMLDELIEEYKNRGFTTFVVSNGTNPEVIEKIEPYQLYISLTAYS
EESHLLLNKPSKNYWEEINKSLKILSDKDGRTVLRLTLIKGYNMKAENYVKLIEKASPTF
IEAKAYMYLGYSRLRLPKTAMPEHADVKLFAEELSKLTGYEIKDESPISRVVLLA
>A0A662GEH3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MERISLKDVRRYLRAGYRLVGRHSAVEVCRWTKSALKGEYMCYKRWYGVKSHRCVQMTPV
LNFCNFACVFCWRPHLSGRFAIPKGWKWDSPSSIVEGVIRAQRELLIGFKGNPKVSRERF
LEAMFPRHMAISLDGEPTLYPMIADLVKEVKDRGMTAFLVTNGSVPYRLEELIRKGAEPT
NLYVSVYGPDPEVFSKSARPLVPKAWDLVLESLELLPRFRCRTIIRLTMVRGLNMVKPEG
YAKLVELGNPCFVELKGYTWVGESQKRLPRSAMPTLTELIEFARRLERFTSYKIKLTDEK
SRVVMLVRDEETWEWNLKLIEEWRKLESRLDEEWKGKVKNFKLKKR
>A0A662VE60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVNSLRKALNTLRKQKYHLIGSHSAVKKCYWVHKALTQKHFCYKGKFYGIESHRCIQFSP
AVLWCWNSCLHCWRLRPSDVMSWEESLLPSIDDPGFIADAAIEEHRRTISGYFAYPNIDK
TMLKEAMTPKHVAISLTGEATLYPRLGELIKEFHKRDLTTFLVTRGIRPDILANLDEEPS
QLYVSIEAYDEESYRYFNKPIFPNLWKLTLKTLEILPSFTSPTVIRITLIKGFNNSEKSL
KKFAKLISVAQPTFIEVKAYMFIGASMTRLSRESMPHHKEVKIFAELLANEIGYNVVSES
KPSRVVLLSKLDKPVIRHGNCPVSWEDPDPGDEFSGEYGEPETAI
>A0A665U123|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
MALKKKSISKDINPWVYKAVKIQNCPDRAAVVHVSGVKIFYGSQTGTAKGFAKELSEEVT
NLGIPSEVIDMKDYDPDDQLPDECTSKSVCVFLVATYTDGQPTENAEWFYRWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGMRVMTRGEGDCNVVKSHN
GSIQADFQAWKVKFLNRLQALAKNEKSCSGNCKTGSSCKNKRNDGQLEVEKENASPQNAV
AEDDLIESTSDEDESGLQDEKKSGAVVDMEDLGRYKLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKILQDSLEKHQ
NMIRQFRGVPGVRPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHQISSFLVTNA
QFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRL
TLVKAWNVEEMQAYSELIAMGQPDFIEVKGVTYCGESSASNLTMANVPWHQEVVAFVQQL
AGMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYQRFQELAHVHEESGGLQSFSAL
DYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A1L9RST1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus wentii DTO 134E9|TrEMBL
MAESSLAQSEGLLALWHSYRLPLLVAISTVFFIVKAYRKSQTKAKTAASSSVPPSPRSQS
PETTEKPRLGENEKPVIARKDSPPAKSSGPKRVSGKKPAKTSRRGEAGDAQPLTHIQPII
FFASLTGATERYANVLLEDMRAAAQKKADPENRERGLLPPQIHDLSYIDFDDFFTSAPKA
PSTSPGTRYIYCLLIPTYNIDTVINTFLSHLDETHHDFRIDTGSLSTLAGYSVFGFGDKS
EWPTEEEGFCSQAKELDRWMAKLTGKRRAYPLGFGDVNSDAEESLKEWSNGLQDIMSDIL
ANGGLGEGVAGSGDPLESDEEDLDDEEGSDTKAKNKKNKPQAVMDLEDIKMGADGQATAS
PLPVDFTTAGKPAAPFQEAKEMVPTTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFNGVKE
GHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLGMLHDEHISSFLV
CNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRFVQR
TVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMKNVPFYEE
ISEFVVALNKELERRGLKYGLAAEHAHSCCVLIASERFNVNGKWHTRIDYDRFFQLLEQE
KADGTPFGPEDYTRETEEWAYWGNGGFDPNDERVYRKGKGPKAKVTEVEE
>A0A7K4QNG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neopipo cinnamomea|TrEMBL
LDVSMDTWSYFRTCLASIWLYRFYIYSAVALGISLWIVIQFTTTKTKKKGEKSSGNPTSS
RGTEDKLVNGCATPQAKEVYVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGD
YDPDDCLAEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRVGKTYLKGLRYA
VFGLGNSEYVDHYNTVGRRLDRWLWMLSASRVMTRAEGDCSVARSRHGSIEGDFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHEASEHENTEAEELFETSSEE
EADAGEAGGTNAVIDVEDLGNIMGHMKKTKVLLFLWVGNGQVFATDQKEEEEKREMITPA
LRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFRGVSGVKAARFEEALTVKH
CALSLVGEPIMYPQINHFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTRE
SLRRIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLGKPDF
IEVKGVTYCGESSASSLTMANVPWHEEVVGFVQDLAELLPDYEVACEHEHSNCLLLAHTK
FKVDGEWFTWIDYERFQELVRERERSGGSRTFTAADYMARTPPWALFGARERGFDPLDVR
FQRRNKARDISGC
>A0A6V7SMC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vinckei brucechwatti|TrEMBL
MVTKREDELVPPPNEGGNINIYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIVFFND
IPNHFNTISTITKGDKKNNTIFDGSISNEINNIEDYMLEYFQSKLLKTNKKNKDRKYGKS
CKNEKENIINNESSKCDNEVKDIFDNLKNYEKNMIKCGNTHFNNYLNCSIENNISEINFD
FVNGNEFDSYTFFENSENNDLNILFMFISTYNFGSFPANCYKLEDTLTDLVNDFRVEKNY
LKNIFYSCVGFGNKEYGSKYFCIPIKKCDKFLSSLGANKLEKTLKLCSTMDNEEEFVHWK
SSLLKNICLSLFLYNYNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSDDSKSMPINDGE
NKQTNKPIDNNNINKCDCINNGMPSEHLNTLKESGNDHNKLTNKTNGHISFLASKIDACN
TEKCGCTSNNCLNGNDKYINEKKIINNNFETSIENGCCKNEYEQDDELVNSDFSNESMSE
NNGEINCNSSEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQIRGR
GGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVK
KHKNMIKELKGVHNVINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLV
TNAQFPNELKKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKEKKERTV
FRFTLVKEYNMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQ
FAFHLVNSKRSISDIYEISCEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVKQNVNF
TAIDYCAETPEWAVVGAPECGFNPSDQRVYTKGKNKKKNNINTMEVKT
>A0A5E4LNS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MVRIRESYKKGKITFSEAARKQYEKSYGIVGSHSGVQICLWNKKSIKGHRGCYKVKFYGI
DCHRCAQMSPTLAWCNEGCIFCWRPMEWMKKTNFEVTEVDEPDLIIAETVKQRKRLLSGI
GGAQGADRRKFDEAFRLFPSHWAISLSGEPTIYPKLSEMVKQLRARKEVRSIFIVTNGQE
PDALKKLNKQKALPTQLYLSLAASNEEMFKKINRSVYKDGWKRLNKTIKLLTKLPCRRVI
RLTIIKGVNDSETAIEEYAKLIEKSTVDFVEVKSYMALGFSRKRLGPKHMAYPEYLKPWT
ERLVTRMPNYRLIDEDTQSQILLLKNKNSRYENFIRKS
>A0A654EZU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabidopsis thaliana|TrEMBL
MSTTSSVRVRLAFVALLSATTFYCIHKYRRLKHLKNLSLNPSSTLKASRGKIFFISQTGT
AKALAQRLHELCASNDIAFDIVDPHSYEPEDLPKETLVLFIASTWDGGKPPKNGEFLVNW
LGESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKEMSSRMIGLGGLEMIPVGEGD
VDDGELDRAFQDWCDGVIRVLKGGSAQETNGVSQQIGAVEDDLEYYDSTDEEDEDNDADG
GIVDLEDIAGKAPSKRNGVVKVTKVDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSV
IVKGALDLHKNMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGR
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
TDVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTEKFKVDGKWFTWIDYEKFHDLVASG
EPFTSTDYMAQTPSWAVYGAQEGGFDPGQLRYKKERNHPPKPQAVLA
>A0A439D1R0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xylaria grammica|TrEMBL
MSALGRWFWSGFSTPRPPTIPGHPPRSGENLNRVLHGRVTKPAHAEATSKAIKYINFVQD
SEDDEEKPATGLPLAMIGQSNEKAGQADSEDSFKDETDPEPDSEPEITDSEDNFEGEMAR
EPDPESDPDTAWRREQIYLNTILNARNEYTLMPSTWRMHFRGIPLPNSLFYVKMKSKSIR
PRIYARTDRLEYRDWAKQDGGIDRYGENIPPNVRIMELAGISATDEPESELKIQLEMCNL
AQEWRTHAAGGGAAVRAPVIFGFVIMKHIITIVTMDAADPCAIIHVPCRLHMAERNQHQW
NALAILVTICWARDVLLDYIDDRPDLQPEVKAESSDPDAYEDWQDTYFLEFWHIHREVIL
VVAICLSSTVWILYSTLPTKRVVKKPPLRPGATARLAPTKPVTLPTEKSEAPLEALSQDV
AAPGPRRIKGELRKPEATQKSSDSDSSRRTQVLIFYSSLTTTTGKIASDFAQNLSASLEG
DARHKDNFFGPIVLDLAEIDYDEYLISPPKPADSAIPVDYFYLFLIPSYNIDTINDNLIE
HLQETHHDFRIDTAPLSGLLGYSVFGLGDREGWPTEEDGFCFQAKEVDRWMAKLTGRKRA
YPLGIADKKLDLTDRLAEWTEGVTDVLKLAATTGSLGEGVPGSGDADESDFEYASGDDDD
EVMVEESAPKKKKNTKTKTNIDDVEDLGRIMKSNQANSNDSKGPTPVAVDFTTYSKSNAK
KVSAQTVKEMVPKSSPTYTSLTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIA
SHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFDGVKAGHYQKIKMMRGV
PGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHAERISSFLVCNAQHPDQLAAL
KAVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFN
VDDEVEGYADLVEHGLPCFVEIKGVTYCGTSTSAGAGLSMANVPFYAEVTEFVTALNKKL
NERGLDYGIAAEHAHSCCVLIASGRFRVDGKWHTRIDYTRFFELLEEHGADGDWKPEDYM
GPETPEWATWGNGGFDPRDERVDRKGRKIEAS
>A0A063ZH20|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halostagnicola sp. A56|TrEMBL
MSDSDETLQVSDPDYHSENHTAAQTCGWTANALRGEGKCYKNIYYGIESHRCIQMTPVVR
CNERCVFCWRDHAGHAYELDGVEWDDPEAVVDASISLQKKLLSGFGGNEKVPDEVFEQAM
EPRHVAISLDGEPSLYPYLPELIEAFHDRDITTFLVSNGTRPEVIRECDPTQLYISVDAP
ERHTFDQVVQAMEDDAWEKLLETMDVLAEKDETRTVLRTTLIDGENMHSPDLYAAYYQRA
DPDFIELKAYMHVGHSRGRLDRDSMPDHEEVVAFAEDVKEHMPEFTECKGVPASNVALLS
KTKDTWVPKLKKDSEFWADDPLAGD
>A0A8C2ANR4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKVIKCNYMQLCCDVFLAGDVIAQGIQCEVMDMKEYDPEDRLAEECTSKMICVFLVAT
YTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKW
LWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKSA
SCKNKKKHKEEAEDSQSHAEKNNSEEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNR
MKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPE
RFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQL
YVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYA
DLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEH
SNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGAR
ERGFDPSDTRFQRKNKTKDISGC
>A0A8J8PWC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. A20-N-G8|TrEMBL
MLAMQSNIRIDTLSEIYKELKKEKYHIVGTHSAYKKCHWTHESLVTNRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDDTKMPAYDDPEYIVERSIEEHKRAVSG
YFGREGVKLEKVKDAMKPAHVAISLTGEPTLYEKLGELIREYHKRGLTTFLVTSGIRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLLMKTLEILPSFSSPTVIRLTMIK
GYNMSDEDAKEFAKLFQIAMPTYIEVKAYMHVGPSTYRLSKDAMPRHNEIREFAKLLSNY
TGYKILSEHVPSRIVLLSKLDEPIKIGNAWNERWDWRTVDIEDDINGEYKEAELGCTEGS
T
>A0A2P5I4E7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diaporthe helianthi|TrEMBL
MEFNLPASPWLEAPDSAIEFWHANRTAIILSTFTVLVLVRVYLHVTEGNEPLHVFPKIYN
EKTHEKIAIPSPPEHKIEEAKQVKPAGPRRIKGELNRRRELQASSSRRISTLVFFSSVTG
NTDKIAKQFVEDFFGLLQAVESGPNCTFAKPEAIDLAEADLDEYFIAPPKLSVDGKAALE
FFYLFLLPSYNIDTINDTFLEHLKETHHDFRIDTAPLSSILGYSVFGFGDRENWPTEEEG
YCVQAKDVDKWMSKLTDRKRAYPLGMGDVKRDGTERLGEWTNGLTDIFGQLARDGTLGEG
VPGSGDAVESDDEADEAEDDGEVIFEDQEPVKPQKSKSSSTMDDMEDLGRVLQNAKDEGN
TKSTAPLAIDFTTESKRKTPVQPVKEMVPKESPTFKSLTKQGYSIVGSHSGVKICRWTKS
ALRGRGSCYKFSFYGIKSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIF
NGVKEGHYKKIKMLRGVPGLRAERFAEAMRIRHCALSLVGEPIFYPHINEFLEMLHGEQI
SSFLVCNAQHPDQLATLKHVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILREK
RFKQRTVFRLTLVKGFNIDDEVQGYADLVEKALPCFVEIKGVTYCGTSTSSNAGLSMANV
PFYAEVCEFVTALDAELNRRGLQYGIAAEHAHSCCILLGSERFRVDGKWHTLIDYDRYFE
LLEERGPDGDFSPEEYMGEETPEWATWGNGGFDPRDQRVDRKGRPIET
>A0A843K3X9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum sp|TrEMBL
MEDVWSTLKRQKYKIVGAHSAVKICHWTKKSLIENRVCYKQKFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDTPYSYDVPEAIVEGCINAQRELLSGYHGFLEKVDINKLKEAEN
PTNVAISLAGEPTLYPDLSGLIEEFRKRKFSTFLVTNGTTPDVLSSMDSYPDNLYITLPA
PTKEIYEHICNPQIKDGWSKLNESLELIQKIKTKRRILRLTLVKDFNMKGVEEYSKLIEK
TNPDYIEAKAYMFVGYSRKRLEVENMPMFDDVLEFCKELEVKTGYKSIDFAKDSRVILLS
RN
>A0A1E1X4R3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amblyomma aureolatum|TrEMBL
EKSSSEWYPSTYTTTLCGGVLAVLFFVVAREKLNLSKIKTHDPFQQRQRKHNGRSVKVLY
GTQTGNAKILSEKLAAELDALDYNVEIVNLKHVEPEECLLGQVKAKGLCVFIVSTYVDGS
APDEATWFYDWLKDTYADFRVHKYYLQGLCYAIYGLGDSTYGDDYNKVAKDLDFWLSRLH
ATRVVPLCLNDESHDEGKYGTGKFSPWKDDVVAYLKGCPSAAILPANPSAPEETVAYESS
SDEGEPELVDLEDLGSVRNTAKLKGQQQSKTARGRGEGEQQDMLTPLLRQSLGKQGYRLI
GSHSGVKLCRWTKAMLRGRGGCYKHSFYGIDSHRCMEATPSLACANKCVFCWRHHTNPVG
TEWKWNMDPPEMIVENALNHHYKMIDEFKGVPGVLRERLSEGRQVRHCALSLVGEPIMYP
EIGQLVRLLHDRGISTFLVTNAQFPEALRTLGPVTQLYVSVDASSREALKRIDRPLFPDF
WQRFHDSLSALADKGQRTVYRLTLVKEWNMDEMQGYANLVALGKPDFIEVKGVTYCGESK
GSNLTMHNVPWHEEVLSFVKQLVALLPNYSIASEHEHSNCVLIAHHKFHINGQWHTWIDY
ERFHELVQGFYKTGASFSSLDYAAPLPPWAVFGAMERGFDPSDTRMLRKSKKDISGC
>A0A7K9ZLB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicrurus megarhynchus|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVVQFTTTTRTKRKVGEDLLQELG
ADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTPLNLPVEVINMGDYDP
EDGLSEETSSRNICVFLVATYTEGQPPENAAWFCKWLEEAANDFRVGKSFLQGLRYAVFG
LGNSAYVDHYNTVGRRMDKWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLT
RLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEAG
GTDSVVDVEDLGDIMGHMKKAKVLLLEGIWNAHGVNHSGYQLVYFVCQFLRAKLNCLMIF
ALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALS
LVGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRR
IDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
GVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKFQVD
GEWRTWIDYGRFQELVREREQSGGSRTFTAAEYTARTPSWALFGARERGFDPLDVRFQRK
NKARDISGC
>A0A3M9YAY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium nonalfalfae|TrEMBL
MSGSRDSWALMPLLNGLHDAWQQVRIPVLLVVALGLVGLRIYLQATGAKPEQLKALPKKL
AADKTVAEKAALARDAKTEKPPLVTEASAAPKAPKTTAGPRRVKGGVVRRRSSDDNVDKA
AARPPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHRAAPETSCTFEAPELLDLAEVDF
DDYFITPPKAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSV
FGFGDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPRTDYAERLAEWSEGIV
EILGQLARTGGLGEGMPGSGAPVESDEEDVDEEDDDETLVEDGEAKPEKLKNSKNLEDVE
DLGRIMKDSRPDAAPAKGKGAPIAVDFTTYGKTAAKMAPAPTVKEMVPKNSPTYASLTKQ
GYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGE
PIFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRP
LHRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDEEVDGYAALVERGLPCFIEVKG
VTYCGTSTASNAGLSMSNVPWYWEVCDFVKKLEARLGEKGLQYGIAAEHAHSCCILLASD
RFRVDGKWHTTIDYQRFFELLEERGPDGEWRAEDYMGPATPEWATWGNGGFDPRDDRVDR
KGRKIEAK
>A0A4U0UID1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Friedmanniomyces endolithicus|TrEMBL
MDLLQLPSELLYLWHTHRTEVLLSVGILFAVVRLALHWRTRRSKQTLTPPALSPIEEKSL
PALIQQPVEPDEYTKLPAPRPPRPDTGPKRVTGTKRTKAIPAAKEPVVDSIQPIIFYFTL
GGTTRAYAEYQASLLASPSRQILNPEILDLAQIDYDDYFISPPKSPSANTAFFYILLIPS
YDIDTELSNFLAHLRETHHDFRIDTAPLAGLAGYSVFGVGDKREWKTEGEGYCKDAIEVD
KWMARLTGRKRGYPLGQGDTSGNGVVETTLREWTEGIKSVIFGLAKGEGLGEGVKGSGEA
VESEDDDDDGEGESGALELEDGRAANLRSQRKPSKRSQTDDLEDLRAPIPVDFTTTRPSS
KTIPPPPKAMVPVNSPTYNSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIA
SHLCMEATPSLSCSNKCVFCWRHGTNPVGTIWRWTVDPPDLVFAGMKEGHYKKIKMLRGV
PGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLAMLHGERISSFLVCNAQHPDQLAAL
GPVTQLYVSIDASNKDSLRRIDRPLHRDFWERFLRCMDILREKRFTHRTVFRLTLVKGFN
IEEEAEGYADLVARALPAFVEVKGVTYCGTSTATGAGLSMGNVPFYEEVQAFVLSLEAAL
LRRGLEYGIAAEHAHSCCVLLADRGRFFKRAEGDEGGERKWHTLIDYAAFFRCLEGGEAF
GPEDYVGEPTPEWAAWGRGGFDPRDERVDRKGKPKVVEVVG
>A0A2D6TI82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MPIALNVVEQKDLKNKQRYSEGYRLVGNHSAVKICEYCKKAITGKDVCYKNTFYGIESWR
CIQMSPTFFCDHRCVFCWRDIEYVWPKWQGPVDDPKDIVEGCIKAHIELLQGFKGNSNVV
KDRLKEMEKPLHFAISLTGEPTMYPKLPEMIDFIKEKGMTAFLVTNGTMPNMVEKLIMHQ
PTQLYISVYGPNKEIYQKTANPISKDAWEKLHKSLSIMHKFKRNVVRLTLVKNYNFVEPE
GYARLIEKYKPMFVECKGFSFIGHAQERLQVHNMPYNDEVLEFAKKIQQNSSYKLIDSKK
ESRVALLARDDFKDRKMNFEGL
>A4YHJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)|TrEMBL
MAVKGSFRIDTLSKIREEMEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMTPVSMWCWFRCIHCWRLEPEDVGLDWDETKMPYMDDPEYIVERSIEEHKRSVSGY
LGREGVENNKALEAMKPSHVAISLTGEPTLYERIGELIREYHKRGITTFLVTSGVRPDVL
ASLEEEPSQLFVSLQAPNEEKHRLINRPVVANSWNLVMKTLEILPSFSSPTVIRMTMMKE
VNMSDDDAREFAKLMRIAMPTYIEVKAYMHVGPSTYRLTKDAMPRHSEVRFFAEKLAELT
GYKIISEHAPSRIVLLSTIDRPMQIGNAWTEKWDWRTQDTQDDVNGEYREAEMGCTEEGD
GPKP
>A0A842SCC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MPVELQKLLEKQQYRFSGEHSAVKICEWTKRSLRDEGFCYKQKFYGIKSHLCCQVSPAVN
FCPHQCTFCWRPQEYNLGFDPVGFDDPEKIIENSIKAQRKLLSGFGGNEKTNKKKFKQAQ
HPNMFAISLSGEPSLYLKLGELIKNLDKREITSFVVSNGIYPEYLSKIIGNNEPTQLYIT
LPAPDKETYMKICKPMIVGGWERINKTLNLLSEFNCRKVIRLTLVKGINMVKPGEYAKIL
DNLDIDYIEAKGYVWVGFSRKRLKEENMPKHTEIKEFSKKIEKNSKYKILDEKKESRVVL
LGN
>A0A7C4TSH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus sp|TrEMBL
MKQLSDLKGYQIFNHSAVKTCLWLKKSLRDEGVCYKQKFYGIQSHRCLQMTPALMCNQFC
VHCWRPLELLKDFRGWDEPERIVDESIKAQKRLLSGFYGTKGINRKKLEEAEKPNQVAIS
LIGEPTLYPYLPELIECYKNRGFTTFLVTNGTNPEMLAEVNPTQLYLSLTAYSEESHLSL
NRPPKSYWTRILESLKVLRDSRSRTVIRLTLIKGLNMDEKAAEGFDRLIRIAEPDYIEAK
AYMFLGYSRLRLKAENMPEHADVVEFSRLLSRRGYEIVDESEQSRVCLLSL
>A0A091REW4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mesitornis unicolor|TrEMBL
LDVSMDTWNFSYTCLLSLWLHRFYIYSVVALGISIWIINQFFTTRKKGEKPNRNPAASER
TENKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKSLAEAVISLDLPVEAISMGDYD
PDDCLVEETTSRNICVFLVATYTDGQPTESAVWFCRWLEDAANDFRFGKTYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRVMTRAEGDCNVSQSRHGSVEADFEAWKAKFL
SRLQALCRGEKKPCNGKCKKGKCKSPGKQRKEGTDHEHKTSEYENTEAEELFETSSEEEA
DAKEVGGTNSVIDVEDLGNIMSHMKKAKVLLLEQKEEDEKREMITPALRDALTKQGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDRPEKILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYP
EINGFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDF
WPRFLDSLKALSEK
>H8X8I8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida orthopsilosis (strain 90-125)|TrEMBL
MTSGSFILSVCAVLYLYNGGRWTIVLSAFVLSYLYKLERKSTSTTVTPVPEATTEDSLKS
PIYAVDFTSTTFTPSTTTNIPKTLRSRAKRSPKIIKASKPTPQQLNEPILTKSQVDLKKS
QIYIFYTTLTGSSLRLAKNLHEKLSLMELVHEPKLLSLDDDVDDLEKYFLKTPKSDENTK
NIYLLVLPSYETDSPIDYFLEHLIDTYQDFRVDKYPLRSILGFAVLGLGDSESWSGDKFC
YQAKLADKWLGKLGGRRLYPLGEVCMKYEGEPKAKEWIQNFAELLVDEEPFYIDENNDDE
FDDSDKEDISDDANTLVDVEDMGDIIRKTGQRSTQQMEVKQMVAKDSPTFKTLTKQGYTI
VGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPV
AKSNWRWELDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFQEAFKVKHCALSLVGEPIF
YPHINEFVGMLHEQHISSFLVCNAQHPDNLAKLSKVTQLYVSIDAPTKTDLKKVDRPLNS
DFWERLMSCLDILRTTQSHQRTVFRLTLVKGFNMTDIKSYADMVERALPSQIEIKGATFC
GSSNGNGNPLTMQNIPFYEECKEFVRALNDELRVRNLGYDIAAEHAHSCCILVAHEKFKI
NGVWHTHIDYPKFFELLESGKDFVDIDYIKPTPEWAVWGSEEAGFNPVDTRWDRKAEKLK
NKIAREEEAKRKEQIPVEVV
>A0A850XNC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aegithalos caudatus|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAAAFGISLWIVIQFTSTRTKRKKSHGNPSSPEG
TADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVEHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKRGSIEADFEAWKGKFL
TRLQALRKGEKKPCTGKCKKGKCKSSGKQSKESLDHEHGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNVMGHMKKAKVLLLGGWADLAQGAQSSCGCPWIPGSAQGQVGHWGLE
QPGTVGGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVQAARLEEALAVKHCA
LSLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDDLKAYADLISLGKPDFIE
VKGVTYCGESSASSLTMANVPWHGEVLSFVQELARLLPEYGIACEHEHSNCLLLAHSKFQ
VDGEWRTWIDYGRFQELVREYERSGGSRSFTAAEYTARTPPWALFGARERGFDPSDVRFQ
RRNRARDSSGC
>U7Q127|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183)|TrEMBL
MASTSWASSPFIRDLLIVVVDAWHAYRIPILLATFAALVSLRIYLHVAGSGDDREGLLIF
PKIYDNTTVVDEKKQLQQQEQPPSVQEDVKIAVLQQTKTISYPGSTSDKKTITPTATKKS
STAKTANATTPSSTTTKAAAGPRRIKGELPKGNGAAAVARVPTRIQTIVFYSSITGATAK
IVRDYATELSTTLGELKPDGGSDSKGNVFAPVEVLDIAEVDLDEYFISPPKDASDAASGR
TTDYLYLFLLPSYNIDSINDTFLEHLKETHHDFRIDTAPLAPLLGYSVFGFGDREGWPTE
DEGFCFQAKEVDKWMAKLTGRKRAFPMGVGNTKTDAMLRLAEWSEGVVDVLGLVARTGSL
GTGVRGSGDAVETDDEDEDEASDDGSDAYDDGSNDDDGAADANGAAYDNDDVLFGGNAAR
NANVKRLKKAGVIDDVEDLGRLLRSSKEDDAVDDTAVDDVAEVPGTNVNKAPIAIDFTTY
GANDSSTTNGGPRRTGRKAAAPTPKEMVAKDTPTYKSLTKQGYAIVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIF
DGVKANHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHSENI
SSFLVCNAQHPDQLAALHHVTQLYVSIDASNRETLRKIDRPLHRDFWERFQRCLAILREV
RFRQRTVFRLTLVKGFNIDDEVQGYADLVEQALPCFVEVKGVTFCGTSTSAGVGLTMANV
PFYDEVCEFVTALEKELQSRGLAYGLAAEHAHSCCVLLASERFKRDGKWHTVIDYDKFFA
LLREKGPQGDFAPEDYMGPPTAEWATWGRGGFDPRDQRVDRKGRPIER
>A0A811MTH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Miscanthus lutarioriparius|TrEMBL
MTVARGPPGRPSSGLLGCWRRRPALGFGAKVGIAIALGLSFAIIWTSVSPTSSSQQISTE
RSSFAAEVAAPPTASHNRTAGGGGGHAHRKPRPVPHSHKKRHPVPSGSHSHPHRSNATAS
PDAAAAKADHSEPAPVTDPEPKEKQPEQEQEQEPDMEMEPEQEAELPVPEQGGDNSGKAP
AEEEEEKPPQLELEDEPSEGDGEEDDPEAAKRKAPSKKRKLPPLFSPGAHYHWKLCGAKS
GYHYIPCVDFDGDGSQRHHERSCPRSPVTCLVSLPKEYKQPAPWPERKGKVWYGNVGHPR
LSNYVKGHNWLNHSGEYLTFPPDEWEFKGSARHYVESIDEMAPDIDWGKNIRIILDVGCK
SAGFGIALLEKDVITLSLGLMNDQTDLAQVALERGIPATVGSLGSQRLPFPSGAFDAIHC
GECNIPWHSNGGKLLLEINRILRPGGYFIISSKSADLESEEGISASMTALCWNAIAYNSD
DVSEAGVKIFQRPASNEVYDLRAKKDPPFCKEEQNKASAWYTHIKHCLHKAPVGIEERGS
DWPEEWPKRLESFPEWLGGTQTRVASDHNHWKAVVEKSYLDGLGIDWSNIRNVMDMRAVF
GGFAAALASKKVWVMNVVPVHAADTLPIIYERGLIGVYHDWCEPFSTYPRSYDLLHADHL
FSRLKIRCKQPVSIVVEMDRILRPGGWAIIRDKLEILDPLETILKSLHWEIVMTFRKDKE
GIIRAWKRPSPPRPKSKLPSSKTQRPERVRPRTHHRRDVSLPGGDHRLHHLPPRPPRAPL
LFLPLLPLQIPPPPPQTLPGRRPHCYSYPSLRSRLTADAGFPVRATDAATFDPDDLPSVP
LLLLVIPTHEGGGPPPSAAFLSRWLEESAADFRAGALLLSGLLFAVFGVGSQVYGETFNA
ASRSFSRWLRALGAVEVVPLGEGDMDGGDLEAVFEEWSRRVLRVVKGEEVGYGANEKSNG
LDELELEGEDWDDDDEEEMVDGEVDMEDIAGKAPARRKNGNLEGVPANGVQNGVKDMVTP
IIRTSLEKQGYKIIGSHSGVKICRWIKSQLRGRGGCYKHSFYGIESHRHHTNPVGKSWKW
KMDDPLDIVNAAIDQHTKMVKQMKGLPGVKPEKLEEGLSPRHCVLSLVGEPIMCPEINAL
VDELHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFSDFWERFL
DSLKSLHEKDQRTVYRLTLVKGWNAEERDAYAKLLDLGQPDFIEIKGVTYCGSSATSKLT
MENVPWHSDVKEFSEVLASKSGGVYEVDKFKINGKWHTWIDYDRFHELVTPGKPFKSRDY
MAMTPSWAVYGAEEGGFDPDQSRFKKERRHGTAAHKSLSS
>A0A2G9NM31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_31_59|TrEMBL
MKLATPTEIAENLKHKHYGLSKHGAVQICLWTKKALRNEGVCYKEKFYDAHCHRCMEMTP
LAVWCNQNCIFCWRPSEWLNLNDLKKELEKPEEMVEKLIEKRKKLLSGFGGSVKKYKTER
LFKESLIPDHFAISLSGEPTLYKKLPGLIKLLKEKYKARTVFLVTNGSQPEMLLKLQKER
ALPIQLYISFESPNENDFLKTNKPRSKNAWKTLMRTFSILPKLDVRKVIRITLMKNINDS
EEKIKQFSMIINESFADFVELKSYMHVGSSRERLKKENMLEHKEIKEISKKFLKYLKNFR
YEDEQKESRIVLLKNKKSPYKTKFD
>A0A0D2A9P5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala spinifera|TrEMBL
MDLGDGGATPVVLADWLDRLLTSWHDYRVAVYSVVALSSLLVWLYRRRAPTSSPDPRKAH
WLEDEDKVALPTANGKTSLDNKQQPATGTTRKPRYSAPKVVNGRKPSPRGGKGSHERDGP
AHILPLVFYTSLTGTTERLSKSVLAKLQSLPTAQPLVLKPQLHDLSYVDLDDYFISGPKT
PGPSSNVRYFYILLLPSYDIDTILNTFLDHLDETHNDFRIDTASLSGLAGYTVFGIGDKN
GWPTEEAGFCSQAVEVDRWMSKLTGRKRAYPLGLGDVKSNIDQTLQDWTAGVCDVLQELS
TTGGLGEGVPGSGDAVESGDEDDEEDRQQEEVDFPDSGRNKRRKLRSTTDLEDVGGKGAV
MAVDFTTYSRSPAAAVAPLKAMVPKESPTYAALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQMIFDGAKE
GHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLHSEQISSFLV
CNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLQRDFWERFQSCLEILREKRFVQR
TVFRLTLVKGFNIDDEAEGYADLVEKGLPCFVEIKGVTYCGTSTSSNAGLTMQNVPFYEE
VVAFVEALDRALAKRGLDYGIAAEHAHSCCILLASKRFLIDGKWNTIIDYDKFFTLLGEG
ADFAPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEKKADKEVLRTVLVEEKKSLEF
>A0A7J4T8T2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDPKLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRGRQCYKGRFYGIESHGCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKTVFDDICKPKWNQGAWEKFEQTIDLMPSLDTRTVCRHTLIKGKNMSHEHIREFAELDN
RADPDYIEAKGYVHVGHSQENLAASNMPSHEDIMAFSHEIAPLTNRQVLDESRPSRVALI
GTEIIPIQVPEAEMYFPEDLGIAPPVKHLPVI
>A0A091DS48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fukomys damarensis|TrEMBL
LDPSLDVWDLSSPLLSLWINRFYIYLGFAFGLSLWIFFQIVIKKQAKNSQTSIPKATQDL
MTNDYISLHKKQIFVSGVKIFYGSQTGTAKGFAALLAEAVTSLNLPVEVINLKEYDPDDH
LTEEIASQNVCAFLVATYTDGRPPESAEWFCRWLEDAASDFRFSKTYLKGMRYAVFGLGN
SAYLSHFNKVGKSVDKWLWMLGARRVLARGEGDCDVVRSKHGSIEADFMAWKAKFISRLQ
VLEKGENKSCGSHCKKGKCESKSPGSEEETEPGSHPQHGSQPRDPEEEEPWESSSEEESG
PDEHLSLNSVVDVEDLGEIMNRMKKEKREKDHREGNTSLFRNTGKSDGSEGRAMITPALR
EALVKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGMEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKPERFEEGMKVKHCA
LSLVGEPIMYPEINRFLQLLHHCKISSFLVTNAQFPAEIINLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKPQRTVYRLTLVKSWNVDELQAYAELVSLGHPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVRELVDLIPDYEIACEHEHSNCLLIAHRKYK
IDGEWWTWIDYNRFQELIQEYEDSGESRTFRAEDYMARTPHWALFGARERGFDPKDMRHQ
RKSGSKNIAGH
>A0A520KR33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoliparum thermophilum|TrEMBL
MIERYKELLKKQGDHIIGSNNHSAVKLCHWLKKSVRGEDECYKSKFYGIVSHRCIQMTPF
IGCNQNCIICWRPTGMSLSFERFDSPEEIVEESIKEQKRLLTGYKGSNRTDIAKYWEAVE
PRHVAISLIGEPTLYPYLDELINIYENKGFTTFVVSNATRPEVIERINPTQLYLSLESFN
REMYKKLCRPIKDEWDNVLRSFKILSDKDCRTVLRITLIKGLNTKPEKFVPLINMASPDF
IEIKSYMHLGYSRQRLARDRMLDQEDIEKFSYVIDKKTDYEVIDESIKSRVVLLSKNNEI
KRFIV
>A2QAJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus niger (strain CBS 513.88 / FGSC A1513)|TrEMBL
MASSSELGHMEDLPTGGYKSIQPFQLKRPVVSEIVWDFFSISQASHIWDTMKERYSSTRT
PLYIGSLSPGTLVNNCQNILEVPPPPPLPPRTPPPPPSPATSSTSNSPNHSPPPPPPPPP
PNTRRRHTSSHYKQRGRHLTCRFAPEAPRDACPIGQFSAGTNQRPRRWSQKIPRKSRGTE
SERTSTDPRTSIDSTLTRRVWAAFVSLCLVLATCIRPSTDSVGYCDVSPGLRQPLSSSSP
SAPRPLYLARLFESFRGDKGSQIPPLSHGSRLFFSIYLRWRDLETKVIMLSLCDRASTNG
SFCLGLLAFWHSYRLPVLLALATLLVLVRAYRKLQPKSKIATASSIPSSPRSHSPEKREK
TFSNSTEKDVGTDSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPAVSFIQPI
IFFASLTANTERYAQVLLEELRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFISAPK
PPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGFGDK
EGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSRGLQDILGEI
VENGGLGEGVPGSGDPLESDEEDLDDEGSESDKANGRKRNKNQSVVDLEDIKFSSDAASG
SPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVKE
GHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFLV
CNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHYQR
TVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEE
VQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEKE
KADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQAAAATEAQG
>A0A7J4UY14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDARTREHLEKQQYRLVGETGAVKLCHWMRQKLIYGRPCYKEEFYGIQSHRCLQMTPAVN
ICNFRCLFCWRFHGMSSFEGVSYPEPEELLEKCILEQRSLVSGFKGDERCDPALWEESRT
PNQVAISLSGEPTLYPELGEFIALCKRKGMTTFLVTNGSVPKALAELSCMPTQLYVTVAA
PNREVFKRLCVPQFDRAWDNLMETLDLLGTLPTRTVVRHTLVKDWNLGWEDEYAKLDERA
DPTFVEPKGYVFVGDSRTRMTIGNMPSHQAVHEFSSRLASRLSMELLAEREDSRVVLLGK
KGTRPRLSD
>A0A5A7RT22|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDNETKNILKKQHYALVGNHSAVKLCHWMRQTLFYDRVCYKQTFYGIETHRCLQMTPAIV
YCTQKCLFCWRYQGFTKTRFTENDIVDDPEEILDKSIEAQRKLITGFKGDTRCNLKKWEE
ANNPKHVACSLSGEPTLYPRLDEFFEICHKRGMTTFLVTNGTNPEVLEKLDNLPTQLYIS
VVAPNKEVYKKLCNPLIKDGWEKLQKTLELLPSLDTRTVIRHTLVDGWNIDGYEKEYAKL
DGKAEPWFIEPKGFVLVGSSRNRLTIKNMPAHNKIREFGRRLAEHLGYEIYGEREDSRVI
LLTRDKKNVKIK
>A0A8J8TSQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronococcus pandeyae|TrEMBL
MSDSADSGTNADGEDDAPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKYIYYGIES
HRCIQMTPVVKCNERCVFCWRDHKGHAYELGDVEWDDPEAVVDASIELQKRLLSGFGGNE
EVPREVFDQAMEPRHVAISLDGEPTLYPYLPELIEAFRDRGITTFLVSNGTRPEMLRECD
PTQLYVSVDAAERHTFDQVVGAMEDDAWEKLLETMEVLSEKDETRTVLRTTLVEGENMHH
PDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHERVVEFTEEVQEYMPEFTELK
DVPASRVALLSKEKDTWVPKLKKGSEFWEDDPLVADH
>A0A2R6I5G4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_4_70_19|TrEMBL
MCADVGHTDMSDSGPEQVDDPDYHSRNHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRC
IQMTPVVKCNERCVFCWRDHQGHSYELDGVEWDDPAAVVDASIELQRKLLSGFGGNDQVP
REAFEEAMEPRHVAISLDGEPTLYPYLSELIEAFHDRGITTFLVSNGTRPEVLADCDPTQ
LYVSVDAADRATFDDVVGAMEDGAWDRLIDTLDVLAAKEETRTVLRTTVLKGFNDHHPEW
YAGMYDRADADFVELKAYMHVGHSRSRLDRSAMPEHEEVLAFTEAVQEHLPTHPVLRDVE
ASRVTLLARDEDTWVPKLKGGSEFWEQEPYA
>A0A093IJL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eurypyga helias|TrEMBL
LDISMDTWSFFYTCLVSVWLHRFYVYSAVAFGISIWLLVQFTPTKTRKKGEKSNGNPASS
EGIEDKLVNGSATLQAKEVYVAGVKIFYGSQTGTAKRFARGLAEAIMSLNLPVEVISMGD
YDPDDCLAEEPGNSLSCVLEIASLVDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYA
VFGLGNSAYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTK
FLSRLQALCRGEKPCSGKCKKGKCKSPGKQSKESSDHEQGASEYGNTEAEELFETSSEEE
ADAEEAGGTSSVIDVEDLGNVMSHMKKAKRERELEEGDVGMSLARENAGRKEEGEKREMI
TPSLREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIEHHQNMVKQFKGVSGVKADRFEEAMT
AKHCALSLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDAS
TKESLKRIDRPLFRDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVAIGK
PDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIA
HKKVSL
>A0A164ZNY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xylona heveae (strain CBS 132557 / TC161)|TrEMBL
MAGSIFSDLLAAWHIFRIPLFIGVAITFVAIRAVSRLRASREKLSSSPAPSSPALDSKKE
APQEWIAPNSLDEKTVSRENNNAESSAAEPISEKEVPIKKKTDAAPKRVTGTKRSKSPKS
NGADTPRAPFKVQPLVFYASLTASTQKSAEGLFEVMKTALAASSRAERFLEPQLHDLSYI
DYDDFFIAPPKIVEDEEAEVLYFYMILLPTYNIDTTLDPFLDHLQETHHDFRIDTAPLSP
LLGYSVFGFGDKEGWPTEEDGFCSQARQVDKWMAKLTGRKRAFPLGMGDVKSDSKERLEE
WRLGVQEALADIVEKGGLGEGVSGSGDPVESDEEEEEEEADAEVEAEADGSSPGDSDAGA
QAKLRVKRRRNKAAAVDDLEDLGSKLRKSDENNNNAEQDSSSDAPLAVDFTTYGKKKSSG
SPSATAPTAKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYG
IKSHLCMETTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPEMIFDGVKEGHYKKIKMMK
GVPGVRAERFQEAMRIRHCALSLVGEPIFYPHINEFTRMLHNERISSFLVCNAQHPDQLA
ALEQVTQLYVSIDASNRDALRRIDRPLHRDFWERFQRCLDILREHRSRQRTVFRLTLVKG
FNIDEEVTGYADLVERGIPCFVEIKGVTYCGTSDSSRAGLTMQNVPFYEEIKEFVIKLDD
ELRRRGLSYGIAAEHAHSCCILLASTNFRINGRWHTLIDYDRFFDLLAEGKPFGPEDYIG
PPTPEWATWGHGGFDPADTRVFRKGKNRKDASEAGETGESVVNDAVDSSPALPGISSAPP
THTAAETETCGSADTPETPSHSAPRAGTCCSSNSNSANGNKSESKSCCRSEEEQLEEEGA
ATEEPEFHANSTNVVVNTFA
>A0A8C5TA81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Malurus cyaneus samueli|TrEMBL
LDVSMDTSSYFHTCLVSIWLHRFYIYSAVAFGITDPENLDKLGNGCASPQAQEVHVAGVK
IFYGSQTGTAKRFAKALAEAVISLNLPVAVFNMGDCDPEDCLSEETSSRNICVFLVATYT
EGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSAYVDHYNTVGRRVDRWLW
MLNASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLTRLQALCRGEKKPCSGKCKKGKC
KSSGKQSKESSDHEHGMSEHENTEAEELFETSSEEEAEGTNSVIDVEDLGNIMGHMKKEK
RELQEGAAGAGRKEEAERREMITPALRDALTKQGEALPRAVGAQFGVGAMLRGRGGCYKH
TFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILQEALEKHQNMI
RQFKGVSGVKAARLEEALRVKHCALSLVGEPIMYPQINRFVRLLHQHDISTFLVTNAQFP
EEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLV
KAWNVDELKAYADLISLGKPDFIEVKGVTYCGDSAASSLSMANVPWHGEVLAFTQELARL
LPDYGIACEHEHSNCLLLAHRKFQVEGEWRTWIDYGRFQELVRERERSGGARTFTAAEYT
ARTPPWALFGAAERGFDPSDVRFQRRNKARDISGC
>A0A0B5HU02|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeon GW2011_AR15|TrEMBL
MLTEKKRLELENQGYRIVGNHSAVKICGWTKNALRSRGMCYKNTFYGIQSWRCVQMTPAL
QHCNFRCWHCWRDIATASREWTGPVDEPKEIVDGCIREHLGLLMGFRGNPNANMKRIEEM
KVPLHFAISLTGEPTMYPRLPELIDEIQGRGMTAYLVTNGSYPEMVEKIIGHEPTQFYIT
LAAPTEEMFIKTTNPLTKHAWERFNKTLQLMEKMKCRRVLRLTLTKGHNMYNPEEYGKFI
KNLHFDFVECKGYVHVGYARYRNTRDNMPTHDEIKEFAAKVAEAAGLKYIDEKPESSVVL
LMKEDRPDRILDFEAELRNEVELPDILDSKPGGLPILNSNSMPKNSGLKIIQESGCGDNC
NC
>A0A816P0C3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria magnacalcarata|TrEMBL
MAVDIDILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSLKS
QPSTKNNSDEKNGITIVFGSLKGNSRTFAKLTSEKLSNELNRHVILQDLKDITDPEEFLQ
IQAKEQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAVFGCGNSL
YTENFNKVATEIDRCLSELGATTLLATELADENTGKSIYGGLEGHYSKWSSKLVSALESK
ATGKCGCRANEDSVTCCKSPSTNSHSKVTNGTNEVLIESDDDDEGGNKDGEEDVMDLEDM
GDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIDNHYKM
INTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQF
PDEIRVLQPVTQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKTKGQRTVYRLTL
VKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVVTFVRLLCE
RLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGAETFTSLDY
MAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>A0A0P9GYX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidiplasma aeolicum|TrEMBL
MINTYKPIYKKQHYGLVGNHSAVKVCHWTKSQLTGHAACYKNTFYGINSHQCIQMTPALN
ACSENCDFCWRFQGFDSMHISQEDDPEFILEESIKAHLKLISGFKGNPKVKKELFEEAQH
PKHMAISLTGEPTLYTRLGELIEAATKRGISTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKKIFNDVLHPAIGNAWENFNRTLEILPSLDTRKVIRHTLVKDVNMPYYDEYEKLDRIA
SPDFIESKGYVHVGQSMDRLAYENMPSHEMVLEFSNELARRLGYTPYADRYESRVAMIAK
DPSKAKIDFEAELKKHMK
>A0A6A5NNR0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lupinus albus|TrEMBL
MSISFSSIHARLTLLALFSATTFYCFYKSRRLRNLKFSLSNRFSNANPKKPMIIFLSQTG
TSKTLAHRLHRLLSSSDVVFDLVDSKNYEPEDLAKETLVLVVASTWEDGKPPSGSNFLAT
WLSETATDFRVGSLLLSRCRFAVFGVGSRAYGETFNAVARDFASQMKALGATEIVPMWEG
DVDGGNLDEDFEIWCGKVVGVLKGGGALENGVVDGDGGECGNDSSFEDSDDESEPESEIV
DLEDIAGKAPSRKSVAVVESNGKLNGKKEMVTPVIRANLVKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWQWEMDDPVEI
VNSAIELHTNMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHKRR
ISTFLVTNAQFPDKIKLLRPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKE
KHQRTVYRLTLVKGWNTEDIDAYFKLFSIGEPDFIEIKGVTYCGSTATSKLTMENVPWHA
DVKAFSEALALKSQGEYEVACEHAHSCCVLLAKTKKFKIDGQWYTWIDYEKFHDLVASGS
TFDSTDYMATTPSWAVYGAEESGFDPAQSRFKKERHHKSSRVQSS
>A0A7C3LQ10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MSRLKNQKYHLIGSHSAVKKCLWVHNALTQGRFCYKCKFYGIESHRCVQFTPATLWCWNA
CLHCWRVRPQDLGLSDKDLMRLPSVDDPEVIADLAIEEHRRTVSGYRNVAPKNMWEEAMD
PKHVAISLTGEPTLYPRLSELIQVFHKKGLTTFLVTRGIRPEVLASLEEEPTQLYVSLET
WNKEMYDFFNRPLISKGWEKTLETLELLPSFSSPTVLRITLIKEFNMSDKDVKGFARLID
KASPTYVEPKAYMHVGGSTGRLSRDSMPSMNEVLDFAEKLAAETGYRIASYSVPSRVVLL
TKLEGPIIRYGKGCPNAWRTEEIGDEFSGEYGQPESF
>A0A497JA80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MVPPADVRLRLERAGYRLVGEHKHSAVKVCHWTKKSLLDRGVCYKEQFYSGDLGVRSHQC
LQFTPSLPFCDHRCVFCWRDTSLTSSSWFGEADDPEDIITEALAAQRLLLSGFGGNPDVN
RRKFEEAQNPRHCAISLAGEPTMYPKIGDLIDECHKRGMTSFLVTNGQHPDVLERLPDPT
QLYISLVAPDSDTYEKTCRPVRPGGWERLSKSLDLMSSFSCRKVIRLTLVKGLNLKDPVG
YARMIRRTDADFVELKAYMFVGFSRKRLKMENMPSHSEIKTFAEELARELGFSVAGESEQ
SRAVLLRA
>A0A178W4L9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabidopsis thaliana|TrEMBL
MSTTSSVRVRLAFVALLSATTFYCIHKYRRLKHLKNLSLNPSSTLKASRGKIFFISQTGT
AKALAQRLHELCASNDIAFDIVDPHSYEPEDLPKETLVLFIASTWDGGKPPKNGEFLVNW
LGESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEGD
VDDGELDRAFQDWCDGVIRVLKGGSAQETNGVSQQIGAVEDDLEYYDSTDEEDEDNDADG
GIVDLEDIAGKAPSKRNGVVKVTKVDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSV
IVKGALDLHKNMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGR
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
TDVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTEKFKVDGKWFTWIDYEKFHDLVASG
EPFTSTDYMAQTPSWAVYGAQEGGFDPGQLRYKKERNHPPKPQAVLA
>A0A6V8CNH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPKEKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSSHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNRDVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLIQN
>A0A6A6Z7B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilinidion resinicola|TrEMBL
MDVSTRLGQLPTEILEIWHAHRLPVIFSAISLIAAIRLIQNARRKREKLSLSPVPISPAK
KDEDISLPWQLEGRTEKQELDLELRAEDSSPPLVQQRSRVPKTVKGVKLKSGQKQAKDFD
HTTDKIQPLIFFSSLAGTTEVFATKFAEELTTWIENTSELPSLLKPELLDLSYIEYDDYF
ISPPKTDPNTKYVYLVLLPSYDIDTVLDIFLENLQETHNDFRIDTAPLSGLLGYTVFGFG
DKQGWPTEEEGFCSQAKQVDKWLAKLTARKRAFPLGMGDVKGAAQERLNEWRLGVQEVLA
EIAAGKGLGDGVAGSGDAVESDEEDIEGVENSDDETPVSTKARRPQKLVRVDDLEDLGRM
INTEEPADSAPLAIDFTTYKSKLKTPAVVQLKEMVPTSSPTHASLTKQGYSIIGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVT
DAPEVIFDGITTAHYKKIKAMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINGLVA
IMHANRISTFLVCNAQHPAQLEALIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCAC
LDILKKRRFEQRTVFRLTLVKNFNMADEVRGYADLVERALPGFVEVKGVTYCGTSAAGGA
GITMENVPFYEEVAAFVEALAEELSNRGLHYGIAAEHAHSCCVLLADKERFLRDGKWATR
IDFEKFFELYEGGGEWRPEDYIGGDTPEWALWGNGGFDPRDTRVWTKGKNKGRVIVGGGG
VGSEKAKRQGVETVGPGGMVLDGAGVVEI
>A0A2D8QZ13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLAKQRYHLVGEHGGVKVCHWTKQSLTADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGHYEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSRELAPLVGREVLSERRESRVALIGK
KMIPVKLPEKIRDLPKDLGIAKPQKLSLPTL
>A0A3M7H918|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKSAASQDAQVIEKVQPI
IFYYTLGGSTKVYAESVAQDLAASSPSSILEPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKVEADVMLKEWTEGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETAAPRKPKRKAANRSKTDDLEDLKAPIPADFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINDLLAMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALANRG
LDYGIGAEHAHSCCILLADRERFYRIPEAEKDNPAAEKKWHTLIDYPRFFDCLESGKPFA
PEDYVGAPTPEWALWGNGGFDPRDERVDRKGRPKEQPKVQEVQE
>A0A2N5VFM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia coronata f. sp. avenae|TrEMBL
MLIGLLDSITSRLSAISPSTANTTATAHEEPRLSTQILYSSLSSTTKKLAQQLTAEITTS
SPHLNASLESLDHLDLDQLIVQTPVHATHQLAVFLLPSYNVESPVDSVLAQFRDALYDFR
VANNSLAGLGYAVVGIGHSDYRHEFCKQALELDHILDGLGARRLIPIRKIDVSVDPERDI
KDYCHHVLQTTFTPSLKSFAELSSIKSQPVKYSSENEEEQEEEEEVDNSDDEFVDYSSPT
KPLSKAEIARQKSQKLLKRKKGNQDPKSGTLDIEDLGAGVPQIADLGEDPSSNSKEEGLE
AQMIKKDMISPMTRKSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQC
MEATPSLACANKCTFCWRSHTNPVGTSWRWKTDDAEFVVEESLKEHDRLIKQLAGMPGVR
ADRFSEARTPRHAALSLVGEPVMFPHIKKYISLLTEKHISTFLVTNAQFPDSLLDLPPVT
QLYLSIDAGTKESLKSIDRPLHRDFWERFLASIDIVRTKKVRTVFRLTLVKGENSDEIKE
YAELIRRGQPDFIEVKGVTYCGYPGSSNLTIKNSPWHNEVIKFVEDLCEEINDPRYRTST
DSNADEAPVAEYGLAAEHAHSCCVLAAHQKYYFDDQWHTWIDYDKFFELVESGASQFDGL
QYCAPTPEFALFGAPQAGFSPEDQRWFRKKTLAKIALDAAGPAVVADPE
>A0A818Y5J9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTIDLYIFAASSALTGLVFYYLAGAEWSLWHLFAIPLYTFVFVVFLSLSIIKRFKSLSKP
LQSLTKIIRQEKNGITIVFGSVTGNCRTFAQLTYDKLSKELNYQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDDTPPPSAKWFVNHLQDAATDFRVSKNELEKLTYAIFRCGNS
FYNDNFNTVAKELDRCLSELGAKKLIPTELADENSGKSIYGGREGHYSKWSSQLKSAFQS
PKTDKCDCSNENSIKCCQSLTNNDHPIEKKENDEQLRIESDDDDEDGGCKNGNDDIMDLE
DMGDYMATHSPTKTTKGPPKEMITPVIRKSLEKQCYKLIGTHSGVELCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAMENH
YKIINTFKGVPGVLPNRLAEDI
>A0A7G9YQM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MKPELENLLKKHGYHIAGRHSAVKTCHWLNRAIRGEGSCYKSQFYGIRSHRCIQMTPTLS
CNHRCLHCWRPVEMPVPLPAPTDWDSPVEIKGSIIREHARLISGYGGSETTDMDALREAQ
KPDQVAISLAGEPTLYPHLPELIDLFHKDAMTTFVVSNGTQPDMIARIAPTQLYLSLNAP
DEDTYLKVCNPCGNFWEEIRESLRVLGRSKTRTRTAVRITLIKGVNMFDPDGYARLLSMC
EPDYIEVKAYMHVGFSQKRLDRAAMPDHEEVRLFASEIGDVAGYRIADDSKISRVVLLSR
DGSVERIQSRR
>A0A2I4EQG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Juglans regia|TrEMBL
MSLSSVPARLTLLALLSASSFYCFYKSRRLRQLKFSLNPIPYTNPNLSHSKAKIFFVSQT
GTSEALARRLFDLLSSNSLSFDLVDPKDYEPEDLPKESLVLIIASTWEDGKPPPNAKFFS
SWLSESAEDFRVGSLLLSRCKFAVFGVGSGAYGATFNAVARDYSKQMRALGANEILPVWE
GDVDNGDFDEVFEAWSAKVVGLLKVGVLDNGAVLRSETEALAGGVSDAESFGSSDEDEDR
EGSAEIVDLEDIAGKGPSRKSTVMAESNGKLNGKKEMVTPVIRASLEKQGYKIIGSHSGV
KICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWK
MDDPLEIVNTAIDLHTNMIKQMKGVPGVKLERLMEGLAPRHCALSLVGEPIMYPEINTLV
DELHRRRISTFLVTNAQFPEKIEALKPVTQLYVSVDAGTKESLKAIDRPLFGDFWERFID
SLKALKEKQQRTVYRLTLVKGWNIEDIDAYSNLFSIGKPDFVEIKGVTYCGSSATSKLTM
ENVPWHSDVKAFSETLALRSQGEYEVACEHVHSCCVLLANTEKFKVNGKWFTWIDYEKFH
DLVASGKPFDSMDYMAATPSWAVYGAEEGGFDPDQSRYKKERHHKSGR
>A0A2K6M758|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopithecus bieti|TrEMBL
MKLPVCVILNLDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQVVSKTQDRNLQ
EKSVPKAPQNLMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAI
INLKEYDPDDHLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLK
GMRYAVFGLGNSAYSSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFR
AWKTKFISQLQALQKGERKKYCGGHCKKGKCESHQHDSEEREEGSHEQDELHHRDTEEEE
PFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDG
ERRAMITAALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAER
FEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLY
VSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQ
LVFLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHS
NCLLIAHKKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANE
RGFDPKDTRHQRKNKSKAISGC
>A0A0F8Q9Y8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei|TrEMBL
MPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSEELAKHLGYEITDESEISRVVLLSKDGRKSPVKKK
>A0A0F8IUE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei|TrEMBL
MPLEEKKEEQENFGENLPEVQEENTGEEPTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQSKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYIRVCQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>A0A6J1XYN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acinonyx jubatus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQGKNSKDKSVPKATRD
LMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQEYDPDD
HLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVFGLG
NSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTKFISRL
QALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGKIMNC
VKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
MILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFLKLLHE
CKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNSLKAL
AAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPW
HEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQELVQEYE
DSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A2K6QU15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopithecus roxellana|TrEMBL
MDLSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRNLQEKSVPKAPQN
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYSSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKYCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITAAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A7M5UP91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clytia hemisphaerica|TrEMBL
MLKIIIKALIALSVVEAVICQSTTLSHDFVIWWSYARFPITGFVFGTIILTWVWIYLNRD
RFVLIDEYEQQRNQPTLKIFYGTQTGTSEKFAGDLMKAAAEQGLSATVIDIKEKDPEQLL
TNQTDGKSICVFIVSTFVDGTPPESCNNFWTFISDSVNDFRVSKLMLKGMKYTVFGLGNS
LYKDSQDVDNYNVFGMNLDENLERLSATRYCKLGLGDDNIQRKDLGNISEDFKEWYGQLL
KQIAKDSVTKEEKINGVTPHEDSNGSVKKVSDEKPATNGDVNYESESDSENTTSGGGGCK
SGAGDDGGLVDVEDIGVVMGKVKQTESEFDEGFVGEKSAPNNREMITPMLKKSLEKQGYK
LIGSHSGVKICRWTKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNP
VGTEWKWKMDEPKKIVDGALENHYKMVKQFRGVPGVKAERYTEAMNVQHCALSLVGEPIM
YPEINELINLLHSKMISTFLVTNAQFPDAIRNLKPVTQLYVSVDASTKESLKKIDRPLFR
DFWQRFLESLTSLSDKGQRTVYRLTLVKAFNTEEIEGYAKLVSLGKPGFIEVKGVTYCGD
SKASSLTMENVPWHQEVVGFVQQLAESLPDYEIASEHEHSNCVLLAHKRFKINNKWHTWI
DYPKYHQLMKDYEESNGTKTFKDIDYMEITPEWAVFGNPHRGFDPDETRWHRKKKADVTG
GC
>A0A497IJ58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MSHEIQELLKKHGYQRAGRHSAVKTCLWLKRSINNKGQCYKSQFYGITSHRCIQMTPTLQ
CNQRCLHCWRAIDATIPKTPWDPPEVIVDETLRAQQRLTSGYGGSDQANKKLWEESKNPL
HVAISLAGEPTLYPYLSELINIFHKKGMTTFVVSNGTHPEVIREINPTQLYLSLTAPDPE
TYQQTCKPEREEMWEDLLKSLKILSGKKGRTTIRITLIEGLNDTKPEEYAKLIKLAKPDY
IEIKSYMHLGFSRKRLERNKMPTHTKINKFAQKIIEHTEYKWADENEPSRVVLLSKDGKT
DKL
>A0A6B2C4B2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MEEKLTLDAKTAEALKRAHYGIYGHSAVEICHWTKEAIRKKSGCYKNKFYGIQTHQCMEF
TPTAVFCENRCIYCWRPNEFYRMLKIPEDWIDEPEEIVKNLEKERKKLLIGFMGGPNIDK
DWLKDALTPTHYSISLSGEPTMYPKLPELIKYLKSLPNTKSIFLVTNGQEPEMLKRLIKE
DALPTQVYLSMNAYDESEFININRPMYKDAWKRWLDSLKLLNEMNTRTVIRITLIKSYND
KLEQIPKAAELIRMGNPHFVEVKSYMHIGYSQSRLSADNMLTFEEIKSFTLKLLSYLSEF
VYMDDMPRSLISVIQNLKRYTDRWIIQGGSYTK
>A0A151QWY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cajanus cajan|TrEMBL
MSISTSLSSVPARLTLLALFSATTFYCLYKSRRLRLLKHKLYPNPNPNPNPKILFLSETG
TAKSLARRLHRLLASNGVAFDVVDCQHYEPEDLPKETLILLVASTWQDGAPPAASRFFXR
SYGDSFNAVARGLAKHLRALGAAEVVPLCEGDVDGGDVDAVFDRWCAKVVEVLKGGGGDD
VAAVEYGDVSSSEEDSDGESEIVDLEDIAGKAPSRKSVANGEESNGKLNGKKEMVTPVIR
ANLQKQGYKIIGSHSGVKLCRWTKAQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGKSWQWEMDDPIEIINTAIDLHTNMIKQMKGVPGVTLERLNEGLSPRHCA
LSLVGEPIMYPEINALVDELHKRRISTFLVTNAQFPDKIKSLKPITQLYVSVDAATKDSL
KAIDRPLFGDFWERFIDSLTALKQKHQRTVYRLTLVKGWNTEDIDAYSKLFSIGEPDFVE
IKGVTYCGSSTTSKLTMENVPWHTDVKAFSEALALKSQGEYEVACEHEHSCCVLLAKSNK
FKIDGQWYTWIDYEKFHDLVASGRTFDSRNYMSATPSWAVYGSEESGFDPGQLRYRKERH
HKSSRNQSG
>A0A851NXD0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penelope pileata|TrEMBL
VSVDMWTFFQACLVSIWLHRFYIYSVTAFGVSLWIAMQFLATKAKRKDEKSNGNILSSEA
VEGKLVNGYTALPAKEVHVAGVKVFYGSQTGTAKRFAKALAEAVISLNLPVEVISMGDYD
PDDCLAEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKAYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVVQSKHGSIEADFEAWKTKFL
SRLQALCRGEKKPCSGKCKKGKCKSQGKQSKESSDQERGAPEYENTEAEELFETTSEEEA
DAEETGGTSSVIDVEDLGNVMSRMKKAEREHELEEGAGGMSPGRKEVAERREMITAALRD
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEALENHQNMIKQFKGVAGVRAERLEEAMAAKHCAL
SLVGEPIMYPEINRFLRLLHQRGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELRAYADLVSLGKPDFIEV
KVSCTELFLPSVLSLFPPHFPTYRVLYEQTLPEVALVCAFKQSAVLSCLLGANAVFQEVD
GEWCTWIDYERFQELARAHAGSGGSRPFTAADYTARTPRWALFGSSQRGFDPQDVRYQRK
GRARDVSGC
>A0A662PPC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MAKLRKAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGIRSHRCLQMTPSLQYCNLMC
IFCWRHHTINRVEAYSGDWDPPEEILDGLIKEQRQLLSGFKGNPRVDRRLFEEAMEPKHM
AISLDGEPTMYPYLGDLIKLARRRGMTTFLVTNGMNPAALKKLVEEDAMPTNLYISVYGH
NEELHRRICRPLIPDSWNRLLESLRMMNEFQGSRKVIRLIMIKDYTMQDPEKYAELIKLA
NPDFVECKGYMHVGESQKRLRKENMPTLDEIRIFAQKLSSELGYEYLAEDYPSRVSLLAN
PSSKYYDEVCRRILKQSGG
>B8D4F2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)|TrEMBL
MVLTIDWDEVRKKREEFWSSSPVYKAIYDRLVKQGYHLIGTIGAVKRCHWSKEAVLRNRY
CYKCLWYGIESHRCIQMTPVVAWCWNRCLHCWRLQPEDIGMHWDDTRPPVIDDPEILVEE
SIRAHREIMAGFKGNPRADQKLVEEALNPKHAAISLTGEPILYPRLGELISEYHKRGITT
FLVTHGTRPDTLRNLETEPSQLYISIESWDKDSYEHFNRPLVPRAWELFNETLELIPSFK
SPTVFRFTIVKGFNDHEIALKNFAKFVEKAQPSYVEVKAYMYIGGSRGRLFKNNMPSHIE
VREIARKIAELTGYTVMSESVPSRIVLLSRVGKPKRHGRGCPDGVENPEKYVPVLTEEYE
EIQD
>A0A0P7BBM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neonectria ditissima|TrEMBL
MHRHRPGLENITAALLLPIVPAVVAAASGGVIAEVLPNPSHAMTTVITSYVLWGIGESFS
ACVLALYFHRLTIHSIPPKEVIVSVFLPIGPLGQGGFGIQQLGKVALTLLPETQAFGSLG
VRGGEILYVLGVFLAIIMWGFALVWLSFALISITTMQNFPFNMGWWGFTFPLGVLATCTS
ALAENLDSDFFKVSSMILSLSVLLFPLEMDWKNHSSPLRLDSLVDDLVEVWHVHRTPILF
AVLAVLCATRIYLRINNEKAELVTFPKVYQEPEKIAIEEKTSAPKTEPQPKRDVKSQGPR
RIKGGLAKKPSNPAENEMDLSRPVLILVFFSSVTTKSEKIAREYVKNLEGSVDQLAEQSG
RSFLKPELRDLTDIDFDDYFIAPSKVHGDVDQVYLFLIPSYNIDSINDTFLEHLQETHHD
FRIDTAPLSPLLGYSVFGFGDKENWPTEPEGFCFQAKDIDKWMAKLTGRKRAYPVGMGDM
RSDHAERLEEWAKGVQEVIGYVARTGSLGEGLPGSGAPDESDVEEEAEDEDDGEVLFDDE
SNEGNKKKNSGTALGDVEDLGRMIQKDDAPTATRKAPLAVDFTSYGSSTKKKTPVRGPKE
MVAKDSPTYASLTKQGYAIVGSHSGVKTCRWTKSALRGRGSCYKFSFYGINSHQCMETTP
SLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKLNHYKKIKMLRGMPGVRAERFA
EAMQIRHCALSLVGEPIFYPYINEFLEMLHAERISSFLVCNAQHPDQLAALKAVTQLYVS
IDAADKESLRRIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEEEAEGYA
KLVEKGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCDFVKALEKRLQEKGLEYGI
AAEHAHSCCILLASDRFKVDGKWHTTIDYKKFFELLEERGVDGDWKPEDYMGEATPEWAT
WGNGGFDPRDDRVDRKGRKIEAS
>G3JE72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cordyceps militaris (strain CM01)|TrEMBL
MDPLGSGYGQSALFNINGLLDVWHTNRTPIILFALCGLLVLRLYLHVYEEKSDLKTIPKI
YEKANPQNSDTVLPRQVQEKTLVKAAGPRRIKGGVAKKSETSEEPVDLNKPVKVLVFFSS
ITTKTEKIGRDFIARLEKSVTQIAAETKRPVLAPELLDLTEIDFDDYFIAPPTSDVGAQF
LYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREGWPDEAEGY
CFQAKELDKWMAKLTARKRAYPVGMGDMKSDHAERFIEWTSGVEEVFDHVIRTGHLGQGV
PGSGAAVESDDEIEEDYDDGEVVFDEENPPKRENGKTSSSLDDVEDLGRVIKSQAGDANP
KAPIAVDFTTYNSKGNAQSKVKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWTKSALR
GRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELIFDGV
KENHYKKIKMLRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKERISSF
LVCNAQHPDELANLKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNRCLDILREKRFR
HRTVFRLTLVKGFNVEDEAAGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLTMSNVPFY
WEVCDFVRALDKRLQEKGLAYGIAAEHAHSCCVLLASERFHVNGKWHTHIDYDRFFELLE
ERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVIREAPE
>A0A7S0Z482|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ostreococcus mediterraneus|TrEMBL
VMDSSSSSSSSSSSRVIRACAVVAVSAWCVARVVRAQRQRRALDAGVTASASASASETVA
TNDGSSLTTRERRMVVYATRTGTSKRFARACAEALDAASGSLNAASGSSSYEVVDLATID
DPEAVFGDSTHAVTAVFVVSTHDGGEVPTPSAWFARWARESAYDERTGWMYLKHVKYAVF
GCGNKEYGDDFNRAGRELDAQLARMGAERLARRCDGDEASGRMEAQFEEWSAKLVRRIAS
VKESSASAHAKDAVMTELQGGSVEDDSVAAYASDDEDDNEAPSVAGSEDDQDMEDIGESE
NNGEKKEMVTDALRGALTKQGYKILGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCTFCWRHHTNPVGTTWRWQMDDPLELVEAAVSEHCKMVKQMKGVPGVL
PEKLEEGMNPRHCALSLVGEPIMYPEIGKFVSELHSRKISTFLVTNAQFPEAITNLPPIT
QLYVSVDAATPETLKAIDRPLFADYWDRFIDSLKSLKDKQQRTVYRLTLVSGWNMEEVAA
YAKLVDLGKPDFIEIKGVTYCGSSDASSLTMKNVPYHKDVCEFGEAIVKLRRDENGEEEY
GLACEHAHSCCILLARTDRYKIDGEWYTWIDYDKFQNLVASGEKFSALDYIECTPSWATY
GAEEAGFDPDQTRHRKVRNHPGKLAPEVEVVA
>A0A7R9FK99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema tahoe|TrEMBL
MILAKSAEEKSLPVELVDLSTYDPEDKLTEETSGQSLCVFVLPTHAEGKPPEAAAWFYKW
LQEAAHDFRVERALLKGMKYAVFGLGNSQYADHFNEVGRSVDHWLHKLQAMRVAKLGAGD
EDTVASRHGSIEADFDDWQNALMGCVEKWRAKSNCRCGGKSQPQEERIEEASSCDSQSDA
GEASDSEWDSDPSQEVKSAVLDMEELGNFSSALRAARKRKESEESEGTREMITPLLRESL
TKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCW
RHHSNPVGTEWRWKMDQPEEILAGALDAHYKMINQFKGVPGVKPERLAEGFQAKHCALSL
VGEPIMYPEINKFVKLLHQKEISSFLVTNAQFPEAISCDITGKNPLPYRWKKRRDYDIIQ
GRDLFLSRLVLSNHQTGTGVAMTSPG
>A0A498HWB4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Malus domestica|TrEMBL
MAVAGLGRQAKRPGGFCIKMTAVAILGLCFIFVWSMFSFSSSSVTTRIESFDNIGKSPGS
KSTRASTPSGTHQVASNGGEEKRANDSAVSSPAREHKYEKEKKEAVNGKKGKGKKKLPES
VAKGKNVTLESENEDSEIEKEDGDEEKEVVDGKEEALGDESEGNGEAGGEGDNLMETMDK
ESEEVKLEDDGGESEKRGKKYKMKGPLFDPKAHYSWKQCSTRSKHNYIPCIDTEVGSGRL
QYRHTERSCPKVEPMCLVPLPRDGYGPPVPWPESKEKILYKNVEHPKLAAFIKEHSWVMK
SGEYLTFPQNQSELKGGILHYLESIEEMVPDIEWGKNIRVVLDIGCTDSAFGASLVDKDV
LTLALGLKDDLVDLAQVALERGFPALVSHFQNRRLPFSSGGFDAVHCGGCTIPWHSNGGK
HLLEMNRILRPGGYFVLSTKHDSFEEEEAMAKLTASICWNILAHKTEEVSDVGVKIYQKP
DSNDIYDLRRKKYPPLCKENENPDAAWYVPVKTCLHPIPSAIEQRGTEWPEEWPKRLERY
PDWLSDKDKLDADTKHWKAIVDKSYLTGLGIDWSKIRNVMDMKAIYGGFAAALAQQKVWV
MNVVPVHAPDTLPFIFERGLVGTYHDWCESFGTYPRSYDLLHLDHLFSRLKNRCKQPVSI
VVEMDRLLRPGGWAIIREKVEVLEPLEGILKSMHWEIRMTYAQGKEVAVDVEDELRKGKL
FFVSQTGTSEALARRLLDFLTLKGVAFDLVNPNNYEPEDLPKETLVLIVASTWDDGKPPP
NAKFFSNWLAESAEDFRVGSLLLSNCKFAVFGVGSRAYGSTFNAVGKDLARRMRALGASE
MFPIWEGDVDGGDLDEVFDAWSGKVVRFLKGGAAENGGVLGNGVGDECEAESFDGSDEED
EEEEDGGESGKGPSRRNPVAATKTNGTVNGKKEMVTPVIRASLTKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDD
PLEIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALIDEL
HRRRISTFLVTNAQFPEKIKMLNPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLT
SLKDKQQRTVYRLTLVKGWNTKDIDAYYNIFGLGNPDFVEIKGVTYCGTSATSKLTMENV
PWHADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTSKFKIDGQWFTWIDYEKFHDLV
ASGKHFDSKDYMAPTPSWAVYGAEEGGFDPYQSRYKKERHHRTNQ
>A0A1Q7L2A6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_3_38_6|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLIGERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRILVLQNQKRFMDRWIAAYANTN
>A0A3P8V9G9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cynoglossus semilaevis|TrEMBL
MVDNCTVYCVQFAKTMIHLLCIIFLSSRVFATDTKASQNEYSITETYFMSIWNKRLYLYT
LAALVFGAWFLLKALWKKKSLKNVDSGVYKAVKNNEQPHTDKVVHVSGVKIFYGSQTGTA
KVFAQELSEEVKTLGITSDVIDMKDYDPDDRLADECTSKSVCVFLVATYTDGEPTENAEW
FCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTR
GEGDCNVVKSRNGSIQADFLAWKAKFLNRLQSLAKGEKKKCSGDCKTNGSCKKKNRKEDQ
VVEKQQQVEEKTSSEEELMESSSDEDETGGKSGSVVDMEDLGNMMSSVRKVKIKEDRRGG
DLLLNGVKKTEDEDERREMITPALRASLTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEEILQDAMEKHQNM
IRQFRGVPGVKPERYEEGLVVKHCALSLVGEPIMYPEINTFLRLLHSHNISSFLVTNAQF
PEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTL
VKAWNVEELQAYSELIALGQPDFIEVKAAPWRLVQSGKVDVYSDSFQATMMTPINPALDT
PCTPFYLTYTFSLLCFLKFPFKGKNLQKISL
>A0A7M3YK29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPLEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRSLAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMYFPDDLGIAESVKHLKIVQ
>A0A5N6H733|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus flavus|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPAPKVVSGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSTAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A6A1WA67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Morella rubra|TrEMBL
MSLSSVPSRLTLLALLSASTFYCLYKSRRIRQLKLSLNPHPSANLLHSKAKLFFVSQTGT
SKALAHRLFNLLASKDLSFDLVDPKDYEPEDLPKETLVLIIASTWEDGKPPSDAKFFANW
LSESAADFRVGSLLLSRCKFAVFGVGSGAYGVTFNVVARDFSKQMRALGAKEILPVWEGD
VDSGDIDEVFDAWSAKVVRFLKGDVLENYEVLRSEALVGGESDAESVGGSDEDENSEGGA
GSEIVDVEDIAGKAPSRKTVAVAETNGKLNGKKEMVTPVIRASLEKQGYKIIGSHSGVKI
CRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMD
DPLEIVNSAIDLHRNMIKQMKGVPGVTLERLMEGLAPRHCALSLVGEPIMYPEINKLVDE
LHHRRISTFLVTNAQFPEKIKMLKPLTQLYVSVDAGTKESLKAIDRPLFGDFWERFIDSL
KALREKQQRTVYRLTLVKGWNTEDINAYSELFSIGQPDFVEIKGVTYCGSSATSKLTMEN
VPWHSDVKAFSEVLALKSQGEYEVACEHVHSCCVLLAKTEKFKLNGKWFTWIDYEKFHDL
VASGKPFDSGDYMAATPSWAVYGADEGGFDPGQSRYRKERHHKSSR
>A0A0H4TSZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured euryarchaeote Rifle_16ft_4_minimus_39|TrEMBL
MWILENVISRPLSIHPQMDAAKREVLERQGYKVVGGHSGVKLCHWTKNSLTGGAGCYKET
FYGIKSHRCLQMTPTVDSCNLGCLFCWRTQEWGSDSLIESDDPGFVVEGSIEAQRKLISG
YGGNPDVPRERFREAWQPNQVAISLTGEPTLYRRLGEMIDEFKRRGMTTFLVTNGTTPAV
LRRMAAENRLPTQLYVTVAAPNAEVYRKLMAPKSDHEWEKLRETLALLPGLETRTVIRHT
LVEGWNLGWEDEYAALDALAGPMFIECKGYSFVGESRLRLRVENMPEHAVIREFASRLAE
RLGYGIAAEREDSRVVLLTRDGRLHPIESGLGTPGEPLYRRSGDAAATSRGPP
>A0A3P9MK29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
AAPQTGSSLAENYLALLWHHRLYLYAAAALVVGLWVSLKVILGMFNFSLCLCFQKSGEKD
AVLSGAKKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKALGFPAEVIDMKDYDPDD
RLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYGRTYLKGLRYAVFGLG
NSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQADFQAWKGKFLSRL
QALAMGEKKICSGKNCKTGSSCKSKKEEEEASKETGSEVRRKEEGVLLTVTELQDGEVVK
FSKLNGVKKIDDDGERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALDKHQDM
IRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQF
PEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTL
VKAWNVEEMQAYAELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLSA
MLPEYEVACEHEHSNCLLIAHKKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDY
MARTPSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A7S4NMD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Guillardia theta|TrEMBL
AAAAAAAAAAAHAGNKGGGKGGGSSRMAGKFGEFLPANQYRRLKRSMAKKQAGVGMYVGG
QASFSSSSSSSSAPFPLGFQFAVCGLGSSSYKSSYQKAAHTLCELLERCGGKRVGPVGEE
DEMFSGQGFELWCKQTLPLLNEEPERRRPEAREESRTLRILWQGDIHEQAARVAGEIAEK
ARDGGAGAGGELAVIAEPLDRFDADSLSTEEALVLVLHRPMSEEEEDGNATMSSEAWLLE
HMKDCYEDERVDKTLLRDLKFGVVYIENNNRTMKDAKLLDFYMFSLSGRRILPVTRVQRT
GKLSDQVQAIAQQLRRNLFPILPSLHDSSHAASDGSRSARDAAVRTSPPTPPPPASASLT
DIEDVGGVEGSSKEMLSPSMRSSLEKQGYKVVGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMEATPSLACANKCVFCWRHHTNPVGTSWMWDMNEPEDILEGCFKGHYDSIRSV
SRVPGVLAPRLAEAFAVRHCALSLVGEPIMYPKINRFVSLLHHNGISTYLVTNAQFPDAI
RDLEPVTQLYVSIDAANPETLTKIDRPLFEDSWSRLAQSLRALKDKDCRTVYRLTLVKDK
NVDDVANYAKLVALGRPHFIEIKGVTYCGTSKASEITMESVPLHSEVVQFARELVEAIRA
EPSVEDEYDIASEHEHSCCILIASRRYLIGQQWHTHIDYDKFITAWRRWLETKELDVMSY
IAPTPPWAVFGAEEQGFDPKEKRMSSKRSREESARLRMEAKNAKGSDLPRVDSNDMSHPQ
G
>A0A897NVJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halapricum desulfuricans|TrEMBL
MSDEGGPRQVDDPDYHSVNHTAAQTCGWTDNALQGEGKCYKYAFYGIESHRCMQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQQELLSGYGGHDDVPRDVFEQAM
EPRHVAISLDGEPTLYPHLPELIEEFHDRGITTFLVSNGTNPEMLERCDPTQLYVSVDAP
DRRTFEETVKPVEDDLWGRLVETLDVLAEKDDTRTVIRTTLVGGENDHNPAWYAAMADRA
GADFFELKAYMHVGHSRDRVDRSSMLDHEDVVAFAESVQQYLPDHDVLKDVPESHVAVLA
PDSDTWVPKLQKDSDFWADDPLVEY
>A0A7J3XE46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MVEMNLGQEIKRYESMGYRIVGKYKHSAVKPCLWCKKALKNEGFCYKHKFYGIESHRCVQ
MTPALFWCTHRCLFCWRNVDATLAPSMEGVALDDPATIVDACIEAHKELLQGYKGNPKVS
KVRFEEAMRPRHMTLSLAGEPTLYPKVGELIEEILSRKMTCFLVTNGTRPDVLAKIHEPT
QLYITLPAPNEEVYRRTCRPLLADGWKRLNQSLELLSSFSCNTVIRLTLVKELNMVNAEE
YGKLVARYEPRYVEVKSFMSVGFARNRLPYESMPLHEEIKEFALKIAEACGYVVRDEQEE
SRVVLLSKR
>A0A7C0U9S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MMEIPEEIKKIMRKQHYKLVGEHSAVKLCHWLRKSIRDEGFCYKQKFYGIESHRCLQMSP
AAFFCTNRCVMCWRSFRTTAGLDMSNIKIDPPEKILDWCIKAQRELISGFGGFSGTNRKK
WREAHNPTNIAISLVGEPTLYPRLSELIEEAGRRGMSTFLVSNGQVPERFLDLTEPTNLY
ISLDAPDKETYKKVDCPQLPDFWERLNRTLEVLNSFSCRKVARLTLIKGWNDRKPEGYAK
LIEKGGFDFIEVKAYMHIGESRKRLPREAMPSHEYVREFAEKISEETGYAYRDEQRESRV
VLLVRD
>A0A8F5BQU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharolobus shibatae B12|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNDKWDWSTIDMEDDMSGEYKEAEQGCTEGS
T
>A3DL01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)|TrEMBL
MQRSIDWEEVRRKREEFWNSSPVYKAIYEHMKKQGYHFIGTIGVVKRCHWTREALVNRRF
CYKCLWYGIESHRCIQMSPVAAWCWLRCRHCWRIQPEDIGMHWDETRIPVIDDPEIIAEE
SIRVHRQIVAGFKGNPKADPLMVEEAMNPKHVAISLTGEPTLYPRLGELIKEYHKRGMTT
FLVTHGVRPDILAGLEEEPSQLYLSLEAWNKQKFMEFNRPIVPRAWELVMETIDLFPSFK
SPTVYRITLIKGFNDSEEALKGFAKLIEKGNPTYVEVKAYMFIGYSRGRLTPANMPSHEY
VREIAKKLADLTGYMVLSESIPSRIVLLSRIKEPIRHGKGCPDGVKHPEKYAWVITHEYE
EMKS
>A0A075MTA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrososphaera evergladensis SR1|TrEMBL
MSCSDEYFSHSTTGEDNNLIQITPRVKEKLKKAKYGVYNHSAVELCHWTKKSFANEGSCY
KHKFYGISTHQCMEMTPTAMNCENRCVYCWRPAEFYDTLEMPEQMVDEPEVIVQNLMAER
KKLINGFYGNSKNDETKLDESLLPAHYAISLSGEPTMYPKLPQLIKYLKTLKATKSIFLV
TNGQEPDMLRRLESEDALPTQIYLSTNASNRKMFLQVNRPRHKGAWERWQDSLHFLSTVD
TRTVLRMTIIRGYNDGSDDIKDFAKVMSEGDPHFIEIKSYMHVGMSTQRLERDNMLGMEE
VRGYANKLCEKMPAFSVMDESEISRIVVLQNKKRYVDRWIKSYFE
>A0A8D2DZD5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sciurus vulgaris|TrEMBL
MDAPPDAWDPASALPSLWTCRFYLYLGFAVGLGLWICVQVLSRQGFATVLAKAVASLNLP
VAVINLKDYDPDDHLAEEVTSSSVCAFLVATYTDGRPTEGAEWFCKWLEEASSDFRFGRT
YLKGMRYAVFGLGNSAYPSHFNKVGKNVDKWLWMLGARRVLARGDGDCDVVRSKHGSIEA
DFRAWKTKFVCRLQALQRGEKSYGGKCESKQHSSEDVEPAPHPGAASRHGDAKEEEPCES
SSEEEFGTDDHGGLSPVVDVEDLGKMMSLAKREKREEEQQEERSSFRNRGKKEGVEGRAM
LTPALRDALTKQVDAAGERWLLQTHLLRHESHRCVEATPSLACANKCVFCWRHHTNPVGT
EWRWKMDQPEKILEGAVQSHLDMMKQFRGVPGVKAERFEEGMKVKHCALSLVGEPIMYPE
INRFLQLLHQRRISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKDSLRKIDRPLFKDFW
HRFLDSLEALATKQQRTVYRLTLVKSWNVDELQAYAELVSLGNPDFIEVKGVTYCGESAA
SSLSMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLVAHRQFKIDGEWWTWIDYG
RFQELIQEYEDSGGLKTFSTKDYMAKTPPWAVFGARERGFDPRDTRYQRKSRSKDLSGC
>A0A7C5X7D8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MDVDPLTRAYERLRKQGYHLIGSHAAVKKCLWVHNALVYGKFCYKCRFYGIESHRCIQFS
PAVLWCWNSCLHCWRLRPGDFGLEGVELLKLPYVEDPEVLAELAIAEHRRTVSGYAKRAS
REMYREAVDPKHVAISLTGEATLYPRLGELIQVFHRKGLTTFLVTRGVRPDVLANLEEEP
TQLYVSLEAWNEEMYRYFSRPMGGNLWRLTLKTLELLPSLSTRTVIRITLVKGFNMGEED
VRGFAKLIERANPTYVEPKAYMHVGASVGRLSRASMPTYEEVMEFAKKLAEETGYRLVSS
SRPSRVALLTRLEKPVYRYGKGCPKAWDEVDVEGEVYEEEYPR
>A0A6A8MLE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosarchaeum sp|TrEMBL
MSCSGETVEEEDKLIQIKPGIVQQLKKAKYGVADHSTVELCHWTKKSFKHEGNCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVAEPKEILTKLMEERKKLIM
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSFLKINKPKYDDSWQRWNKTLEMLKQLDTRTVL
RITLIRNYNDQKEMIPAFASMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVRKFS
EEIAKQSQIFSIMDESLVSRIVILQNNHRVIDRWISDYANTN
>A0A8D3CXF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MSKLTFCCSKYEEEISLFKKSYIYKGILTLCLLRCSHCTVSHCLLKSVCVFLVATYTDGQ
PTENAEWFCKWLEEASTDFRYGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLS
GMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKN
TRKEEQVVEEKANSEVMTWDDPLIKYQNFKTVKTITAISQIWIKLSKMNGVKKIEDEGEK
REMITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVKPERYE
EGLAVKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVTQLYVS
VDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELI
ALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEHEHSNC
LLIAHTKFKVAGEWWTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPGWALFGACEQG
FDPADMRFKRRNKAKDISGC
>A0A2J8T1Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pongo abelii|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEAAIDFRFGK
TYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIE
ADFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQRGSEEREEGSHEQDELHHRDT
EEEEPFESSSEEEFGGKDHQSLNSIVDVEDLGKIMDHVKKEKREKEQREEKSGLFRNMGR
NEDGEIRAMITPALREALTKQVDAARERRLLQTHILWNESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWRRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCGESSASSLTMAHVPWHEEVVQFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIGG
EWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQRKN
KSKAISGC
>A0A673K480|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
QELSAETEKVIHVSGVKVFYGSQTGTAKVCIHCKMICVFLVATYTDGQPTESAEWFSKWL
EEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDC
NVVKSRHGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHS
LAEKNNSEEELMESSSDAESSSEEEKFHGSVIDVEDLGNVMNHMKKAKVKTKPAPPTLNL
DISFGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCGFC
WRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQFKGVPGVRPERFEEGLTVKHCALS
LVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVD
REWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRFQRK
NKTKDISGC
>A0A1F2P817|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Syntrophoarchaeum caldarius|TrEMBL
MLESQGYHLFGEHKHSATKRCLWLRRALRGGELCYKGKFYGIASHRCIQMTPSIHCNHEC
IHCWRPFIDKNEEIIWDMPSELIKGVLTEHRRLLSGYGGSDKTDHKRLLEAEVPKHVAIS
LIGEPTMYPYLPQLIDEFNKMGLTTFLVTNGTNPDVLKAVRPTQCYISLNAPNKVLYEHV
CQPEGDYWENIMKSLEIMAKANWRRTIRLTLIKGINMIDPEAYAELIRLAKPDFVEVKSY
MHLGHSRMRLDRGNMPAHHEIKEFADDLLEFMDEYCIRNEVEISRVVMIGKKESSYNCIL
EV
>A0A517LBZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Venturia effusa|TrEMBL
MAFPLNIWELPQELLELWHDYRNPIILSAVAILTAARIYLRLRVGREKLSESPIPGSPQS
LFDEKPGKLPVAIPGLEEKHVQDFTYIEPKRIQRKTSPKRVKGMKLRPLAKDAAIFDSEM
DCIQPLVFFSSLAGGTEQRARELVEKMSQWISDADFAGIDRVLSPITHDLSYIEYDDYFI
NPPKDSRTKFFYMILLPTYNIDSVLDIFLEHLKETHNDFRIDTAPLSGLVGYSVFGFGDK
EGWPTEEEGFCSQAKEVDKWMAKLTGRKRAFPLGMGDVKSDSKERLEEWRLGTQEVIREL
MAGNGLGEGVQGSGDAVESDEEDNEPESKSNLDDVEDLGRSYRNGQTSKAPLAVDFTTSS
RTKPLVSTVKEMVPKDSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYG
IASHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFEGVKAGHYKKIKMMK
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNAQHPEQLA
TLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFIRCLDILKERRFEQRTVFRLTLVKG
FNIEDEAEGYADLVERALPCFIEVKGVTYCGTSTSSSAGLTMQNVPFYEEIQAFVIALNA
ALERRGLAYGLAAEHAHSCCVLLASERFKIKGKWHTLIGYEKFFNCLESGKPFKPEDYVG
EPTPEWALWGHGGFDPRDERVDRKGRPKDLNLGPRSVGRVVEI
>A0A225AMQ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces atroroseus|TrEMBL
MADSSLVSGLLSAWHTFRIPIIVSLAVVVFLVRSLNLSRRSKSPLSNSLPPSPRLGNATS
TEKPDVTLLDSESIQTSDKPKQKAAASGPKRVIGNKQLRGGKHSRQADQLTGPSFIKPII
FFASLTVSTEKRARWLAEELRKAAHRKSQPGDKEQGLLPPDIYDLSEIDFDDHFVSAPKS
PPNSPNTRYVYCILIPTYNIDTIIDTFLSHLDEIHHDFRIDTAPLSSLAGYSVFGFGDRE
GWPTEEEGFCSQAKDLDRWMAKLTGKKRAYPLGMGDAQTDADNALKEWTSGLAEVLFDIV
ETGGLGEGIPGSGDAYESDEESLAEDDESITKASSNAKGAQTVIDLEDINLGGSGKKRKG
GPLPVDFTTMGKTPASQSNLKEMVPSSSPTYAALTKQGYTIVGSHSGVKICRWTKSALRG
RGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPELIFKGVK
EGHYKKIKMLKGIPGVRAERFAEAMRIRHCALSLVGEPIFYPHINDFLGMLHDEQISSFL
VCNAQHPDQLATLHRVTQLYVSIDASNRDSLRRIDRPLHRDFWERFQRCLDILREKRHIQ
RTVFRLTLVKGFNVEDEVSGYADLVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYE
EVVAFVVALKDELQRRGLKYGIGAEHAHSCCILLASQRFYVNEKWHTRIDYDRFFELLQK
EKSEGISFCPEDYMKETEEWALWGNGGFDPNDTRVRRKGKNKDPVVVEQ
>A0A7K6TX79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aegotheles bennettii|TrEMBL
LDVSMDTWNFSYTCLVSLWLHRFYIYSAVAFGICVWIVVQFFTTKTKKKGKKSNGNLASS
EGTEDKLVNGYAPLQAREVRVAGVKIFYGSQTGTAKRFARDLAEAVISLNLPVEVISMED
YDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYA
VFGLGNSVYVEHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLNRLQALCRGEKKPCSGKCKKGKCKSSGKQSKEISDHEHGASEYENTEVEELFETSSEE
ESDAEEAGGTNSVIDVEDLGNIMSHMKKSKVLLLHWVQNFKIDGLVHFLFSGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWR
WKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINR
FVKLLHQHSISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRF
LDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASNL
TMANVPWHEEVVHFVQELAHLIPDYEIACEHEHSNCLLIAHKKFKMDGEWCTWIDYDRFQ
ELVREHEGSGGSKTFTAADYTARTPHWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A8C9DG73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prolemur simus|TrEMBL
LDPSLDMWDLSSSLISLWINRFYIYMGLAFGISLWICVQIVIKKQGFATILAEAVTSLDL
PVAIINLKEYDPDDHLVEEVTSKNVCIFLVATYTDGRPTESAEWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSAYASYFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVGRSKHGSIE
ADFRVWKTKFIYQLQALCKGGKKKSCGGNCKKGKCESNQHGSEETEPRPHTPDELHPRDT
EEEEPCESSSEEEFGTEDRQGLNSVVDVEDLGKIMDRVKKEKKEKEQQEEKTSLFRNTGK
NEDGERRAMITPALREALTKQVDASRERRFHRCMETTPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEMILKEAIENHQNMIKQFKGVPGVQAGRFEEGMAVKHCALSLVGEPIMYPEI
NRFLKLLHHCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQ
RFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSAS
SLTMANVPWHEEVVRFVRELAELIPDYEIACEHEHSNCLLIAHKKFKVDGEWWTWIDYSR
FQELVQEYEDSGGSKTFGAKDYMSKTPHWALFGASERGFDPKDTRYQRKNRSKDISGC
>A0A832ZUT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldiarchaeum subterraneum|TrEMBL
MAEIIPVTAVAKKQKREEVKLVEKFQQSGYRIIGRHSAVKVCHWTKSALRGDKMCYKHWY
GIDSHRCIQMTPSVQYCNLMCVFCWRFHTPNRVEPYDGSWDDPAEILDKMIEAQRQLLSG
FKGNPRVSRERYEEAINPKHIAISLDGEPTLYPKLAEFIQEAASRGMTTFLVTNGTMPER
LEELKRKGAEPTSLYISLYGPDKESHIRTNKPLIPDSWERILKSLEVMRSFTSRKVIRLT
LVKGYNMHSPEKYAELIKIAKPDFVECKGYMHVGESQKRLPKEAMPSTDEIVEFAKQLAG
ILGYVYVTEDNASRVALLADPSSRYYLEQLEKMRMEASLSTAEEPAVELTGGEGCGEIM
>G4YIR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora sojae (strain P6497)|TrEMBL
MAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAILSTWTHGKPPEDARVFC
NWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLDRELSELGSPSLVQLGL
GDDNVDQFQQFDVWMDNLVAAMCCSGAEEEPQPCEDREGWEEGVAVPEGAVELNEEDLMN
EQFLVDDFSDDEEQNQQKTNDDDGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEG
YKIIGTHSAVKLCRWTKHQLRGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHK
NPVGRVWRWKTDDAETLVKGSIERHQSMIKELKGLPGLIPARWDEAFTVRHCALSLVGEA
IMYPQINEFCKQLHNRHISSFLVTNAQFPEKIAALNPITQLYVSVDAATKESLRAVDRPL
FKDFWERFLACLRELKHKGQRTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYC
GKSDGSDLTMKNVPWHEEVRGFCSALCDRVSGEYALASEHAHSNCVLIAKKKFCRDGVWH
TWIDYERFHELVAKYYEDGTPFTADDYTAPTPHWAVYDSKEQGFDPFAYQSTESGCG
>A0A6A5WAZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amniculicola lignicola CBS 123094|TrEMBL
MAFQDNVQRLPTELLLIWHSHRVPVLLSAVSLVAIVRLALYFRGKREKILYSPVPGSPAE
KVIVDLKPEWLPENTTLDPSTLDIDNHAEDTTLATVTASKGKKGPKRVKGKKKGSDKRKE
ITPGFDHKSDSIQPIVFFQSLSGTTERYATQFVKTFTSWTSSSETPSSLLEPQIHDLSYL
EYDDFFITLPKAESNIKHFYVILIPTYNIDTVLSTFLENLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPSEEEGFCSQAREVDRWMAKLTGRKRAYPLGMGDVKGDAETRLGEWRFG
VQEALVEIAEGRGLGEGVPGSGDPAESGDEDEDVADDSGSETAPAGLKSKKSGRVDDVED
LGSMVTTSPSDAPIAIDFTTYKSTKPRPTPVPKEMVPITSPTHASLTKQGYSIIGSHSGV
KICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWI
TDAPDLIFDGITAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQLL
EIMHSNRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCA
CLDILRNRRYEQRTVFRLTLVKGFNMAEEVKGYADLVERALPGFVEVKGVTYCGTSAAGT
AGLTMENVPFYEEVAEFVTELEKELVARGLTYGIGAEHAHSCCILLADSSRFKPNGLWAT
RIDFDRFFELYDGNVEGTRIERGEDGKEKIVGWRPEDYIGDETPEWALWGKGGFDPRDVR
VYRKGKGPNANKGNGEKSEESEVRVVEI
>J4UWV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Beauveria bassiana (strain ARSEF 2860)|TrEMBL
MDPLSGANGQSALFNINGGLSGLLDVWHTNRTPIILLALCGLVVLRLYIHAYEEKPYLKI
IPKIYQNTDYKNVAYKKSDNVSPPQVQEKTAVKTVGPRRIKGGVTKKPETTEESIDLNKP
VKVLVFFSSITTKTEKIGQDYIAKLEKSVAQLAAETARPILAPELLDLTEIDFDDYFIAP
PKSDDGAQFLYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLMGYSVFGFGDRE
GWPDEAEGYCFQAKEVDKWMAKLTARKRAYPVGMGDMKSDHAERFSEWSSGVEEVFGQII
RTGYLGQGVAGSGAPVESDDELEEDYDDGEVVFDDEKPSKRENGKSSSNLDDVEDLGRVI
KSQGGDANPKAPIAVDFTTYNNKSNPQNKVKEMVAKNSPTYAALTKQGYAIVGSHSGVKI
CRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVD
PPELIFDGVKENHYKKIKMMRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGM
LHKERISSFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCL
DILREKRFRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAG
LTMSNVPFYWEVCEFVRALDRRLQEKGLAYGIAAEHAHSCCVLLASERFHVHGKWHTHID
YDRFFELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVVREA
PE
>A0A838W659|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVYSHEMSADDNLIQITPSIKKKLNKAKYGVFNHSAVELCHWTKKSFSDDATCYK
HKFYGISTHRCMEMTPCAMNCENRCIYCWRPTEFYDTLEMPAHLVDGPELIVHSLLEERR
KLISGFYGKKNANAAKLDESLFPEHYAISLSGEPTMYPKLPELIKYLKNLKATKSIFLVT
NGQEPDMLYRLQEEDALPTQIYLSTNASNKNMFYKINGPRHKDAWERYLKSLEFISTAKT
RTVLRVTLIRNFNDDEKHYSEFASLMEKGSPHFIELKSYMHIGMSINRLEASNMLEMDEV
RNFSQGINKYLLGYLTMDESVISRIVVLQNTKRPVSRWVENYALSS
>A0A7K4EZC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGETVEEEEQLLQIKPVISAQLKKAKYGIADHSTVGLCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPDQVAEPEQILTKLMAERKKLIN
GFYGDSRNDKQRLDESLLPAHYAISLSGEPTMYPKLPELIKYLNSLEATKSVFLVTNGQE
PDMIQKLQDQDALPTQLYLSTNAADYESFMRINKPKYDDSWERWNRTLNMLKDLNTRTVL
RITLIRDYNDQKESIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMDEVKKFS
EEIAKQSEIFSIMDESIVSRISILQNNERYIDRFIPTYANTI
>A0A8C3EXL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corvus moneduloides|TrEMBL
MDTWSYFHTCLVSIWLHRFYIYSAIAFGISLWIVVQFTTTRTKRKGEKSHGNPASSEGTA
DKLGNGCALPQPQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGRQSKESSDHEHGTSEHENTEAEELFETSSEEEAGG
TDSVVDVEDLGNIMGHMKKAKRERELEEGAAGTGRKEEAERREMITPALREALTKQGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALSLVGEPIMY
PQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTQESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLITLGKPDFIEVKGVTYCGES
SASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKFQVDGEWRTWID
YGRFQELVREHEQSGGSRTFSAAEYTARTPPWALFGARELGFDPLDVRFQRKNKARDISG
C
>A0A150JBM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MEDVWSTLKRQKYKIVGAHSAVKICHWTKKSLIENRVCYKQKFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDTPYSYDVPEAIVEGCINAQRELLSGYHGFLEKVDINKLKEAEN
PTNVAISLAGEPTLYPDLSGLIEEFRKRKFSTFLVTNGTTPDVFCCNYTPNVCSIKIEGV
FIFDGSDKEGLINEWKEKKRLDTDKFLFIHNSILYRCFVEAVGVSKDINVPSPVSIPTVS
VKKEVEPGEGLVYG
>A0A7J9Q9R1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilaceae archaeon|TrEMBL
MSCSGEVVEGEEQLIQIKPAISEQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLDATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLGMLKHLNTRTVL
RVTLIRNYNDQDYMIPAFAKMFKESSPHFVEIKSYMHIGRSTNRLEHSNMLEMDEVKRFS
EQVAKQSEIFSVMDESFVSRISILQNNERFIDRWIPAYLNTN
>A0A7L3VY08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Molothrus ater|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTTRAKRKVTEPSRGSPSS
PEGASDKLGNGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEIINME
DYDPEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRY
AVFGLGNSAYVDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKD
KFLTQLQALCRGEKKPCRGKCKKGKCKTSGKQSKESSDHEHGTSEQDNTEAEELFETSSE
EEAGGTDSVIDVEDLGNVMGHMKKAKVLLLEGVWNVHSVNHSGYHLVYFMCQFLQAKLSC
LMICALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKH
CALSLVGEPIMYPQINHLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDF
IEVKGVTYCGESSASSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHCK
FQVDGEWRTWIDYGRFQELVRERERSGGTRTFTAAEYTARTPPWALFGAKERGFDPLDVR
FQRKNKARDTSGC
>A0A532TVY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon B3_Hades|TrEMBL
MVISARELAELERAGYRFVGKHKHGAVKVCHWTRKSLLERGSCYKEQFYERELGMQSHRC
LQFTPSLPFCDHRCIYCWRNINVTHSNWVGEVDEPADILDGAISAQRKLLSGFGGNPDVN
KKKLKEAQEPKHCAISLAGEPTLYPKINELVEECSRRGMTSFLVTNGMHPEVLEHISEPT
QLYISVVAPDLETYEAVCQPTVPDGWGRLNRSLELMSSFTCRRVIRLTLVKGLNLKDAPG
YAKFIEKAAPDFIEAKSYMWVGYSRKRLTLENMPLHGEVREFSEALARETGYKLVDESKV
SRVILLKG
>A0A1G7GMT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorientalis regularis|TrEMBL
MLLPAHPKRGGNMSDSESGSGGPKQVSNPDYHSENHTAAQTCGWTKNALRGEGKCYKNIF
YGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDASIELQTKLLSG
FGGNDEVPREMFEEAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEV
LAECDPTQLYVSVDAADRATFDETVKAVEDDAWKRLIDTLDVLAGKDETRTVLRTTCIQG
LNMHHPEWYASMFQRADPDFVELKAYMHVGHSRGRLDRDSMPDHERVVEFAEDVMEHMPH
DVLKQVPASRVALLAEDRNTLVPKLQKDSDFWE
>A0A7S4FXA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eutreptiella gymnastica|TrEMBL
MNTFEFSGEIFWPTVVVIFCTISLVDTIRRIYGWRTSGTHQPNSQRCITILYATQKGTAR
QLSQEAASELLQLGVKTKVVNLADYDPEDFPAERFVAFITATYEGGQAPVAAQDFFKWLE
DYTMDFRVSKDVFAPINYTILGLGNSVYADKGHYNRVAVDLDKWLQTLHGRRVAQVQLAD
EQEGLLDACKQWLEELKVVGVRYANAEPLPAVTESPVKLHANATSEAGNAAEEDEQEEEE
EEDDGNADDDTMSTPSAMTDLEDLGEIYGKKTNAEMLNPRLRNSLTKQGYKLIGSHSGVK
LCRWTKAMLRGRGGCYKHTFYGIKSYQCMEMTPSLACANKCVFCWRHHTNPVTKQWRWKM
DDPEFLVEQSVDAHVGMINTLKGVPGVKPERLQEAYTPQHCALSLVGEPIIYPEINELVR
LLHARHISTFMVTNAQFPERIDQLAPVTQLYISIDAATKESLKAVDRPIFDDFWERFTGS
IDSLAKSGQRTVFRLTLVKDWNMEELAAYAELVKRGRPDFIEVKGVTYCGDNSASNLTIK
NSPYHEEVLRFCQSLCDASNGLMGDCYALACEHQHSVCTLIGNKKFCKNGKWHTWIDYDK
FHELANGDTPFSPMEYTMETPEWAVVGAPERGFDPVEVRHLRKQKAEQQA
>A0A6P4P7B0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium arboreum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLSQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPQTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGYTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPIGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A832JSL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
MDQKLVLEAVRRYLRAGYALVGRHSAVEVCRWTKSALKGGHMCYKRWYGVRSHRCVQMTP
VLNFCNFACLFCWRPHVEGRFEIPAGWRWDEPADIVEGAIYAQRKLLVGFKGNPQTTMER
FLEAMHPRHMAISLDGEPALYPRLAELIREVKARGMTAFLVTNGSVPSRLEELIERGAEP
TNLYVSVYGPNREVFERSAKPLTPKAWELVMETLDLLPRFSTRTIMRLTMVKGLNMVDPE
GYAKLIERAQPRFVELKGYTWVGESQKRLPIDAMPKLGELEAFASKITELTGYRVKVSDE
KSRVVMLVRDEETWEWNLKLIEQQRALEEKLDAEWRKKVGDFKIRNLPPPPVPVLTPDDL
RRLAGAVPQRSHAGENAPF
>A0A1L9WYV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)|TrEMBL
MADFSVDEGLLAFWHLYRLPLLLALVAAFTFIRFYRTLQPKSRTATASSIPPSPRSHSPE
KSEKIAIGYDEEATKVEKSTIQTIAEKEKAPKSTSGPKRVSGKKPSKVAGRRAGSDQEQQ
PLSFIQPIIFWASLTGSTEKYAQVLLEDLRAAAQERADPENRERAILPPQIHDLSYVDFD
DYFAAAPKPPPNSPGTRYVYCLLIPSYNIDTILNTFLGHLDETHNDFRIDTAPLSSLAGY
AVFGFGDKEGWPTEEEGYCSQAKELDRWMAKLTGRKRAYPLGFGDVKGDAEAALKEWSHG
LQDILGDILEHGGLGEGVPGSGDPLESDEEDLDEEGSDDSSKKNRKRNKAQDVVDLEDIK
FSADGQSGSGAPVPVDFTTAGASPASAIQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWK
VDSPDLIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFL
DMLHSERISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLDILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAG
AGLTMQNVPFYEEIQEFVTSLNKELERRGLKYGLAAEHAHSCCALIASERFYVNGKWHSR
IDYDRFFELLEKEKADGTPFKPEDYMSETLEWALWGNGGFDPNDERVYRKGKKKGLQAAA
AAQD
>U5D5G3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amborella trichopoda|TrEMBL
MKLRGEPYTFLNMISIQSHHHQLAFLAALLSATAWCFYKSTTLRTQRRESTNLLHSSHLD
HYKKPKNQQLKCSSSSSCNCSTSREQPDNSCCRSAKIFFASETGTSEGLARRLLQTLNAS
SKQLMCSFELVDPSRYEPEDLPKENLVVIVASTWEDGKPPRNSQFLAQWLHESSNDFRVG
STLLTSCKFAVYGVGSSSYGPKTFNKVARVFSHQMEALGAIEILPLCKGDVDTGDLDQSF
NHWCIQIIDRLSGLGDRLSSSNLRSIEVASSSKGEDEEEKASDGIEEDSDDDKENNASDG
FEEDSDDDKENNDGESVVDLEDIAGKGPSREPPQNGKVGRRRKSFGKTQADVKPLSSMNR
VENGERREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHR
CMEATPSLACANKCVFCWRHHTNPVGKSWQWKLDDPLEIVNAAIDEHTKMIKQMKGVPGV
TTERLFEGLSPRHCALSLVGEPIMYPEINALIDELHKRRISTFLVTNAQFPERIRILKPV
TQLYVSVDAATKESLKAIDRPLFGDFWERFTDSLRALREKEQRTVYRLTLVKGWNAEDID
SYYELFSVGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALASKSGSEYEIAC
EHAHSCCVLLARADKFKVNGQWFTWIDYERFHDLVASGVPFGGKDYMAATPSWAVYGAEE
GIELITKFLIYFLFVRTTVIQLQNDNKAQNEQDRPPFRAEVELS
>A0A7M4EK39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crocodylus porosus|TrEMBL
MDASVDIWSYLYTHLMSLWLHRFYIYSCAAFGISIWICIQFFAGKIKKQGGKASRKPASL
EVTDDVLVNGYATPKAKEVYVAGVKIFYGSQTGTAKGFAAVLAEAMIALTLPAEIINMRE
YDPDDCLAEETISKNVCVFLVATYTEGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSVYIDHYNTVGKNIDKWLWMLGANRVMTRAEGDCNVAKSKHGSIEADFAAWRAR
FLLRLQALCKGEKKSCSGNCKKGKCKSKVKQSREGSDHEQRVSEQENSEVEELFETTSEE
ESGAEEDGDVSSVIDVEDLGKLMGHMKKAKKEHELDERAGRMDRSFRTIGKKEESEQREM
ITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHQCMEATPSLA
CANKCIFCWRHHTNPVGTEWRWKLDQPEMILQEAIENHQSLIKQFRGVPGVKADRFEEAM
VAKHCALSLVGEPIMYPEINRFLKLLHGHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLKALAKKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELAELLPDYEIACEHEHSNCLLI
AHQKFKINGEWYTWIDYNRFQELVQNYDESGGSKTFTAADYMARTPCWAVFGSRERGFDP
LDTRYQRKNKKDISGC
>A0A7M4EK39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saltwater crocodile|TrEMBL
MDASVDIWSYLYTHLMSLWLHRFYIYSCAAFGISIWICIQFFAGKIKKQGGKASRKPASL
EVTDDVLVNGYATPKAKEVYVAGVKIFYGSQTGTAKGFAAVLAEAMIALTLPAEIINMRE
YDPDDCLAEETISKNVCVFLVATYTEGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSVYIDHYNTVGKNIDKWLWMLGANRVMTRAEGDCNVAKSKHGSIEADFAAWRAR
FLLRLQALCKGEKKSCSGNCKKGKCKSKVKQSREGSDHEQRVSEQENSEVEELFETTSEE
ESGAEEDGDVSSVIDVEDLGKLMGHMKKAKKEHELDERAGRMDRSFRTIGKKEESEQREM
ITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHQCMEATPSLA
CANKCIFCWRHHTNPVGTEWRWKLDQPEMILQEAIENHQSLIKQFRGVPGVKADRFEEAM
VAKHCALSLVGEPIMYPEINRFLKLLHGHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLKALAKKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELAELLPDYEIACEHEHSNCLLI
AHQKFKINGEWYTWIDYNRFQELVQNYDESGGSKTFTAADYMARTPCWAVFGSRERGFDP
LDTRYQRKNKKDISGC
>A0A7M4EJZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crocodylus porosus|TrEMBL
MDASVDIWSYLYTHLMSLWLHRFYIYSCAAFGISIWICIQFFAGKIKKQGGKASRKPASL
EVTDDVLVNGYATPKAKEVYVAGVKIFYGSQTGTAKGFAAVLAEAMIALTLPAEIINMRE
YDPDDCLAEETISKNVCVFLVATYTEGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSVYIDHYNTVGKNIDKWLWMLGANRVMTRAEGDCNVAKSKHGSIEADFAAWRAR
FLLRLQALCKGEKKSCSGNCKKGKCKSKVKQSREGSDHEQRVSEQENSEVEELFETTSEE
ESGAEEDGDVSSVIDVEDLGKLMGHMKKAKKEHELDERAGRMDRSFRTIGKKEESEQREM
ITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHQCMEATPSLA
CANKCIFCWRHHTNPVGTEWRWKLDQPEMILQEAIENHQSLIKQFRGVPGVKADRFEEAM
VAKHCALSLVGEPIMYPEINRFLKLLHGHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLKALAKKGVTYCGESSASNLTMANVPWHEEVVHFVQ
ELAELLPDYEIACEHEHSNCLLIAHQKFKINGEWYTWIDYNRFQELVQNYDESGGSKTFT
AADYMARTPCWAVFGSRERGFDPLDTRYQRKNKKDISGC
>A0A117DWC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus niger|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKTIQAAAEAQG
>A0A7D6GX46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema sp. YPL30|TrEMBL
MSDSANPGADGASADATTDADGGDGDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGK
CYKNIFYGIESHRCIQMTPVVRCNERCVFCWRDHKGHSYEMDDVQWDDPEAVVDASIKLQ
KKLLSGFGGNEEVPREVFDQAMEPRHVAISLDGEPTLYPYLPELIETFHDRDITTFLVSN
GTRPEMLRDCDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMDVLADKDETRTVLR
TTLVKGENMRDPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPEHEEVIEFAEEV
REYMPGFDEVMGVPASRVALLSQTSDTWVPKLQKDSEFWERDPVTGD
>A0A1G5VDL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter millerae|TrEMBL
MSFNKSQLEQLEKSGYRFVGKHGHAAVKTCHWTRQSIVDKGVCYKEKFYGIESHRCLQMS
PAVPNCQQECEFCWRDLTYTQTEWEDEEYDDPKTIVDGAIEAQNNLLCGYYGNDKANPKK
LEELKSPTNAAISLAGEPTLYPKIDELIGEFNRRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPSSKIYEELCRPRISDAWNNLNESLETMASFNSRTCIRNTCVKGRNMIYPEKYA
ELIEKADPNYVEVKAYMFVGSSRERLTMANMPEFHEVKEFAKAIGDECGREIVNESEISR
VVLLE
>A0A2V5HF56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus violaceofuscus (strain CBS 115571)|TrEMBL
MAEFAVDEGLLALWHFYRLPLLLALVAAFTFIRFYRTLQPKSRTATASSIPPSPRSLSPE
KSEKLAIGYDDEVTKVEKSTIQTIAEREKAPKSAAGPKRVSGKKPSKVAGRRAGSDQDHQ
PLSFIQPIIFYASLTATTEKYAQVLLEDLRAAAQERADPENRERAILPPQIHDLSFVDFD
DYFAAAPKPPSNSPGTRYVYCLLIPSYNIDTILNTFLGHLDETHNDFRIDTAPLSSLAGY
AVFGFGDKEGWPTEEEGYCYQAKELDRWMAKLTGRKRAYPLGLGDVKGDAEAALKEWSHG
LQDILGDILENGGLGEGVPGSGDPLESDEEDLEEEGSDDSSKKNRKRNKAQDVVDLEDIK
FSADSQSGSGAPVPVDFTTAGASPASAIQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWK
VDSPDLIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFL
DMLHSERISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLDILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAG
AGLTMQNVPFYEEIQEFVTSLNKELERRGLKYGLAAEHAHSCCALIASERFYVNGKWHSR
IDYDRFFELLEKEKADGTPFKPEDYMSETLEWALWGNGGFDPNDERVYKKGKKKGLQAAA
AAQD
>G3W9G4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sarcophilus harrisii|TrEMBL
MDASLDTWDPFYAPLISLWMNRFYVYMGLAFGVSLCICVQVVSKKLGDRSTGKSSLQKAS
PAPAAPVANGSASHQKKEVHVSRVKIFYASQTGTAGGFAVTLAKAVAALGLPVTVVNLKE
YDPDDHLGEEVTSKNICVFLVATYTDGRPPDSAEWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSLYESDYNKVGKNIDRWLWMLSARRIMTCAEGDGNVVRSRHGSLEADFAAWQAH
FLTRLQELSRGSCGQKKACRPHRRGSCDKGKCKHKKKEGKTPEEGQEFETTSEEESGADE
GQSHGSVMDVEDLGKLMGSMKQAKKEREQQDMQLGKNGAGERREMITPALREALSKQGYQ
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPDMILEQAVENHRNMIRQFKGVPGVKASRFEEGLQVKHCALSLVGEPIM
YPEINRFLKLLHQHRISSFLVTNAQFPMEIRNLEPVTQLYVSVDASTKESLKKIDRPLFK
DFWQRFLDSLRALAAKQQRTVYRLTLVKAWNVEELQAYAELVSLGEPDFIEVKGVTYCGE
SSASNLTMANVPWHEEVIHFVEELVDLLPNYEIACEHEHSNCLLIAHTKFKIDGEWWTWI
DYDRFQELFQEYETSKGSKTFSAKDYMAKTPHWAVFGAGERGFDPKDTRFQRKNKSKDIS
GC
>A0A0M0BU27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|miscellaneous Crenarchaeota group-1 archaeon SG8-32-1|TrEMBL
MLQKQKYHLVGNHSAVKRCRWLYNSIIQERTCYKEKFYGIKSHKCLQMTPSVFHCTLGCV
FCWRAQSGDHNIHWDETQMPKWDDPETIIDGCIREQKRILTGYKATPNVNHKKRLEAITP
KHAAISLTGEPTIYPHLDGLIKNFHKRGLTTFLVSNGTNPEALSKLKEEPTQLYVSVSAF
DKKIFSKICRPQVNNAWKRLNETLELLPSFNCPTVIRLTLAKHLNLEYPECFVDLIKKAN
PTYIEPKSYMHVGFSRLRMEYSHMPTHAEIKEFANKIILKLNYNILDEASDSRVVLLSRL
EKAIKLA
>A0A7J8F058|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rousettus aegyptiacus|TrEMBL
MDPPLATWDFSPLISLWINRFYIYLGFAFGISLWICFQIAIRKQLFIFKDKNSQEKSVPK
TTQDLMTNSYISLQKKEIFVSGVKIFYGSQTGTAKGFATVLAEAITSLDLPVAVIDLKEY
DPDDHLVEEVTSKSICAFLVATYTDGRPTESAEWFCQWLKEASTDFRFGKTYLKGMRYAV
FGLGNSAYASHFNKVGKNVDKWLWMLGAHRIMTRGEGDCDVVKSKQGNIEADFRAWKTKF
ISQLQILRKGEKKPCDGNCKKGKCKSNEHISEEIETGSHAQDGLHQRDTEEEEPFESTSE
EEPDTEDHQSLSSVVDVEDLGKIMNRVKKEKREMEHKEEKTGLFRNTVKNEASERRAMIT
PALREALTKQGYQLIGSHSGVKLCRWTKLMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTV
KHCALSLVGEPIMYPDINRFLKLLHEHKISSFLVTNAQFPMEIRNLKPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKSWNVDELQAYAELVSLGSP
DFIEVKGVTYCGESSASSLTMANVPWHEEVVHFVYELVDLIPDYEIACEHEHSNCLLIAH
KKFKIDKEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMAKTPHWALFGASERGFDPKD
MRYQRKNKSKDISGC
>G0H2I6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis X1|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
FEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCLRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILSENSIFKIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A3Q3BJQ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kryptolebias marmoratus|TrEMBL
MLILLLTVCLVSGFGSPSDAEDRQDVQRSGGKYLVWIWTNRMFVYSAAALVFGTWFLLKV
ALKRTNSTEAAAPRDSKAAKNVSRSAKDPEVHVSGVKIFFGSQTGTAKGFAKELSEEVQA
LGTPAEVIDMKDYDPDDRLADECVSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTFLQGLRYAVFGLGNSVYVGHYNTVGKNIDKWLWMLSATRIMSRTEGDSDVVKSRNG
SVQADFQAWKLRFLSRLQALAKGEKKSCSGNCKKGGSCKNKKKHRPDEEEKASSHDNSSE
VDLIDSSSDDDESGFLDEKRSGSVVDVEDLGNIMSSVKKAKSKDKDEEDQVVRLSKLNGV
KKMEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGV
PGVKPDRFEEGLAVRHCALSLVGEPIMYPEINAFVRLLHRRRISSFLVTNAQFPEEIRSL
APVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVE
EMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKFKVDGEWRTWIDYDRFQELVQAHEDSGGQQSFSALDYMARTPSW
ALFGAREQGFDPADTRFQRRNRTKDISGC
>A0A067L1Y3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Jatropha curcas|TrEMBL
MSLSSRSARLTLLAVLSASTFYCFYKSRRLKLLKDSLNPSLNRNSNSVCSSNKGKLFFIS
QTGTSKNLAQRLHNLFKLNDLSFDLIDAKDYEPEDLSKETLVIIVASTWEDGKPPSNANF
FSNWLAESADDFRVGSLLLTNCKFAVFGVGSRAYGDTFNAVAKDFSRRLRELGANEILTV
GEGDVDGGELDGFFEEWSEKVVGILKGGRVENGEVFINGCIGSESDNENIVDEFGSDDDE
NVGVESGIVDLEDIAGKGPTRKFNAVVETNGKLNGQKEMVTPVIRANLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKNWQ
WKMDDPLEIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLHPRHCALSLVGEPIMYPEINT
LVDELHRRRISTFLVTNAQFPEKITMLKPVTQLYVSVDAATKESLKSIDRPLFGDFWERF
IDSLKALKEKQQRTVYRLTLVKGWNTEDIDDYFKLFSIGQPDFIEIKGVTYCGSSATSKL
TMENVPWHADVKAFSEALALKSKGEYEVACEHAHSCCVLLARTEKFKINGQWFTWIDYEK
FHDLVASGKPFNSKDYVAATPFWAVYGAQEGGFDPDQSRYRKERHHKSSR
>A0A8J7YF08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus sp. SCGC AD-155-M21|TrEMBL
MISKEIYLILRKQHYQIKDHSAVKLCGWVKKSLLENKNCYKSKFYGIETHRCIQCTPSVV
WCQQSCIFCWRVLPTDLGKNKDLSYNKLRWKEPKEVIEDIFEMHRRVIMGYKGILDRIGE
KKFKELLTPKHVAISLSGEPTLYPYLGELINLFHKRGLSTFVVSNGILTEVIQEINPTQL
YISLDAYDLDSYKRICGGRKEHWQNILNTLDILESKGRTCIRTTLIRDYNEDIKKFIPLY
ERGDAHFIELKSYMNVGYSRRRLALEDMLKHNEILELSKRAEELTHYKLMDDSYDSRVTL
LMNENRKIDRFLK
>A0A8D6T0M3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus sp. SG1|TrEMBL
MIPEEIYKILRKQRYQIYNHIGVKLCGWVRKKMLEDKNCYKSQFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPTDINIDINKIKEPKWEEPEVVYEKILELHRRIIMGYGGVIDRVGEK
KFKEALEPKHVAISLSGEPTLYPYLDELIKIFHKKGFTTFVVSNGILTEVIEKIEPTQLY
ISLDAYDLESYKRICRGKEEYWGSILNTLDILKEKKRTCIRTTLVRGYNDDILKFVDLYE
RANVHFIELKSYMHVGYSQKRLSKENMLQHEEILKLAKILEENSSYKLIDDNEDSRVALL
QNENRKINPKIFE
>B3T327|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine crenarchaeote HF4000_ANIW93J19|TrEMBL
MIFSMSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVSDHSTVELCHWTKKSFRGEGTCYK
HKFYGISTHRCMEFSPAGMYCENRCVYCWRPMEFYETMEMKPENVAEPEEIMTNLMAERR
KLIMGHYGDPNQDKKKLDESLLPSHYAISLSGEPTMYPKLPALIKYLKSFEATKSIFLVT
NGQEPDMIQKLGDENALPTQLYLSTNAADYESFLKINRPRYDDSWERWNKTLKMLSTLDT
RTVLRLTLIRGYNDNEKMIPAFASLLRQSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEV
RSFANKLVQENNAFTVMDESEISRIVILQNKKRFVDRFIPAYS
>A0A3B6N002|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum aestivum|TrEMBL
MPPSPAAAAASHLALLLLLSSSSLFFLYKSITLRRLXRSLRPSPSPSSSPAAAAAPTLLY
ASATGTSKALAARLSARLANAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAPPPGA
AFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGAVEVL
PVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDDDDDE
EEEEEEVASAEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQGYK
IVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGKSWKWKMDDPLDIVNTAIEEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIM
YPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFS
DFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTYCGS
SATSKLTMENVPWHADVKEFSEVLASKSDGIYELACEHVHSCCVLLAKVDKFKINGKWHT
WIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFRKERRHGAAALKG
>A0A7K5HC40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crotophaga sulcirostris|TrEMBL
LDVSMDMWSFFYTCLVSAWLHRYYVYSAVGFGVSIWIIIQFFTHKKKGEKSSSNPASSEG
IEDKLINGYATLQAKEVHVAGVKILYGSQTGTAKRFATGLAEAIISLALPVEVTNMGDYD
PDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKVKFL
SRLQALCRGEKKSCSGKCKKGKCRSLGKQSKESSDHEHGASEHENTEAEELFETSSEEEA
DGEEAGGTNSVIDVEDLGDIMNHMKKAKRNSIETLMLNNFVYQLLQGKIDGLIYFLVSGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWQMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMMAKHCALSLVGEPI
MYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLF
KDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELRAYADLITLGKPDFIEVKGVTYCG
ESSASNLTMANVPWHEEVVRFVQELADLIPNYEIACEHEHSNCLLIAHKKFKINGEWCTW
INYDRFQELVREHERSGGSKTFTAADYTARTPRWALFGSRERGFDPLDVRYQRKNKARDI
SGC
>A0A8C2Z9I5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyclopterus lumpus|TrEMBL
MKRYRLRVTRVHQERVLQPESVLVCMHSRFPRINNVIVPSESYLMSVWHNRLYLYSAAAL
VFGIWFSVKVALKKSSDHSDRDAVAAHVSGVKIFYGSQTGTAKGFAEELSEEVKTLGVPA
KVIDIRDYDPDDQLADECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTY
LKGLPYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSAVRIMTRGEGDCDVVKSRHGSIQAD
FLAWKVKFLIRLQALVKGEKKSYSGNCKTKGSCKNPKKDGQEEEEETTALQNSSEDELVE
SSSDEEESGLQDEEKSGSVVDMEDLGNIMSSAKRAKSKEEAGADQMVKISKVNAVRKIDN
EGERREMITPALRKALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILHEAMEKHQGMIRQFRGVPGVQP
ERYEEGLAVKHCALSLVGEPIMYPEINAFICLLHSHRISSFLVTNAQFPQEIRNLVPVTQ
LYVSVDASTRDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLSY
SELIALGQPDFIEVKGVTYCGESAASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHE
HSNCLLIAHTKFKVDGEWWTWIDYERFQDLVQVQGESGGQRGFSALDYMAKTPSWALFGA
NEQGFDPTDTRFQRRNKTKDISGC
>A0A3Q1BUN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amphiprion ocellaris|TrEMBL
MLSLFVTVLVFTGVVCSSDSRASQDVHSPSENYLMSIWHNRLYVYSAAALLFGVWLSLKM
ALKNKSFSKDAALWVRKAEQKNNSSSDRDAEVHVSGVKIFYGSQTGTAKGFANELSEEVN
TLGIPAEVIDMKDYDPDDQLADECVSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRN
GSVQADFQAWKVKFVNRLQALARGEKKSCNGNCKTGGSCKNKKKEKQEEEERAAAQNNSS
EEELIESSSDEEESGPSDEKKSGSVVDMEDLGNIMNSIKKAKAKGEVQGDGQMVKLSKLN
GVKRVEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQSMIRQFR
GVPGVKPERYEEGLSVKHCALSLVGEPIMYPEINAFIRLLHFYRISSFLVTNAQFPQEIR
SLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWN
VEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQY
EIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELAKAHEESGGQQSFSALDYVAKTP
SWALFGAQEQGFDPTDTRFQRRNKTKDISGC
>A0A2G2X119|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capsicum baccatum|TrEMBL
MPLSLSSYPTRLTILTLLSATTLYFFYKSRRRLKSLNPNNPQTPKGKIFYISQTGTSKTL
AKNLHICLKLNGFEFDLVDPKEYEPEDLCKESFVLVVASTWDGGKSPENGGFFVDWLNES
VDDFRVGGLLLSECKFGVFGVGSGSYGDKFNVVARDFSRKLRKLGGVEVLELCEGDVDEG
NLDEIFGEWSKRVVGVLRDENGGGGYMGNDEVGDVRDEEEYNDDDDDELEENDEGLGIVD
LEDIAGKGPSRKKGVGDNKLVNGKLSGGVVNGEKAMVTPVIRASLEKQGYKIIGTHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWTWKM
DDPIEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEINSLVD
ELHKRRISTFLVTNAQFPDKIRLLKPITQLYVSVDAGTKDSLKAVDRPLFGDFWERFLDS
LKALKEKEQRTVYRLTLVKGWNTEEVDAYSSLFSIGKPDFVEIKGVTYCGSSATSKLTME
NVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKMNGQWFTWIDYEKFHD
LVASGKPFTSKDYVTSTPSWAVYGAEEGGFDPEQLRYKKERHHKSSRKENGSLKE
>A0A067CBL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saprolegnia parasitica (strain CBS 223.65)|TrEMBL
MVSIKAPQVAMAAGLALVLASIAYVLSKDKSATRSLPPTSPKAKANGCCNGSGACSSSTA
DAAEPKPVTVRILYGTHTGTAKGFADALQKKLFALNVAGYAFEPSVVDMKDYDQDNLEHE
EVVISILSTWTNGVPPESAKLFFNWITDMAQDFRVSKTWLKHVHVATYGLGNAEYDEHYC
TAAKQLSKHFATLGANRLIKRGDGDDNQDQSAHFEMWSDMLVASLCEQYGSLAAPKQEAK
EFLSQKEFRRQKRKEKAIAAGEDDEEVMITDEDRMNEIVLEEDDDEDDAPKPKGDGVVDV
EDLGVVMKESEAAALNREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYK
HTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDDPVELVEGAISRHQNM
IKEVKGLPGLIQSRWEEAFTVKHCALSLVGEPIMYPHINEFCKELHARQISSFLVTNAQF
PDKIAELEPITQLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLRQLKAKGQRTVYRMTL
VKEHNMKEIDNYVELIQIGMPDLIEIKAVTYCGKSDASDLTIKHVPYHEEVRAFCELLCS
KLGGAYGLATEHAHSNCVLLAKTQFKIDGHWHTWIDYDKFHELIQRYYADGTPFSTMDYI
APTPHWAVYDAPEAGFDPIETRFRRTKEGKVVEIEYTATDSGCG
>A0A3F3Q2F7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus welwitschiae|TrEMBL
MEGSGNEGLLAFWHSYRLPLLLALATLLVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISNSTEKDVGTDLKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPAVSFI
QPIIFFASLTANTERYAQVLLEELRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSESDKANGRKRNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPF
YEEVQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQAAAAATEAQG
>A0A507QY40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monascus purpureus|TrEMBL
MADSSVAAVEGLLALWHFYRLPVLFGLFTFFLSLHAYRKLQRRSKTAASSSIPPSPRDSS
PEKTEKLGASAIRSKDSTPVDSEKKNLQPLDNGRRSPKPVSGPKRVQGKKPLKALGGRRG
DSVESQPLTSIQPIVFFASLTGTTEKYAQVLLEDLRSAARSRSGTDNPEQGLLLPQIHDL
SYADLDDYFTSAPKPPSTAPGLRYVYCLLIPSYNIDTVINTFLGHLDETHHDFRIDTSSL
SNLAGYSVFGFGDKEGWPSEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAEQAL
KEWSRGLQDILFDILEQGGLGEGVPGSGDPLESDEEELDDEDVLDGTKSQSRKRNKDQIV
VDLEDINLVDGQTIGGAPIPVDFTTAGTSSSRPAEVSAKEMVPKTSPTYAALTKQGYTIV
GSHSGVKICRWTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVG
TTWRWKVDSPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYP
HINQFLDMLHSEHISSFLVCNAQHPDQLASLQRVTQLYVSIDASNRDSLRKIDRPLHRDF
WERFQKCLEILREKRHVQRTVFRLTLVKGFNIEDEASGYADLVEKALPCFVEIKGVTYCG
TSTSAGAGLTMKNVPFYEEVSQFVVALNNELQRRGLKYGIAAEHAHSCCVLLASERFHIN
GKWHTRIDYDRFFELLEKEKSDGTSFAPEDYTRETEDWALWGNGGFDPNDERVYNRGKNR
NRKNVAEVAGEP
>A0A7D5MCG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosarchaeum sp. AC2|TrEMBL
MSCSGEIVDEEKLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVSEPKEILTKLMEERKKLIMG
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEP
DMIQRLQDEAALPTQLYLSTNAADYDSFLKINRPKYDDSWKRWNRTLEMLKHLDTRTVLR
ITLIRDYNDQKEMIPAFAAMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVRRFSE
EVAKHSEIFSIMDESLVSRIVILQNNQRSINRWISAYSNTN
>A0A7J2YCX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaerales archaeon|TrEMBL
MSCSDEMNPSVNLIQIQPSVMKQLKKAKYGVFNHSTVELCHWTKKSFVNEGECYKKKFYG
IDTHRCMEFSPAGMLCQNRCVYCWRPMEFYDFMEMPADNVDAPETILNNLMQERYRLMNG
YFGNTKVDKNKLKEAMMPSHYAISLSGEPTMYPRLPELIKYLKSLKNTKSIFLVTNGQEP
EMLHRLQEEDALPTQLYLSTNAPNRRLFYMINKPRYKDAWDRWWRSLAFLSQTKTRTVVR
ITLIKSLNESLDLIPDFADMIKHGNPHFIEVKSYMHVGYSNQRLEESDMMEMDEVRKYAD
TLACAIGHYRFMDESVESRVVVLQNTLRDVDRWVA
>A0A8C5LPE6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptobrachium leishanense|TrEMBL
MKWKMMGMQAFLCASLLHCVCADHVDADTSGTWDFIYTHLMLLWINRFCIYSCAAVGIAL
WICSHFISRKSKEPKYSSQNGSPVLQTEKLEKENHCSPKEIFVSGVKIFYGSQTGTAKGF
AHLLAEDITGLGLPTDIINLMEYDPDDHLAEETTSKNICVFLVATYTDGQPPKSAEWFCK
WLEEASNDFRYGKTFLKGMQYAVFGLGNSVYSNHYNTVGKNIDKWLWMLSASRIVTRAEG
DCNVVKSKHGSIEADFSAWKFKFLERLQALMEGETKACTGKRKKGTCKSMKTSSTEALAE
EENRADNSENEQTEEELYETTSESEPEEAGEGGSSGLIDVEDLGKAMRNMKKSKNVGSDP
GSPGKPVQSEEPREMITPALQKALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCVETTPSLACANKCVFCWRHHTNPVGTEWKWKMDQPEMILEEAIENHQNMIKQF
RGVPGVKADRFEEGMAVKHCALSLVGEPIMYPEISRFIRLLHEREISSFLVTNAQFPEEI
RCLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAW
NVDELRAYADLVTIGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLLPD
YEMACEHEHSNCILIAHKKFKIDNEWWTWIDYEKFQYLIREFKKSGGRQKFTALDYMAKT
PEWALFGSKERGFDPVETRFQRKKTKDISGC
>A0A420HTL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erysiphe neolycopersici|TrEMBL
MSSVVFGFRNLLWPAKTKNPVELWHYHRTSIILTAFTVFIAIKVLVYLRAARKKHSDYNS
SIAEQHLVPSPEKKENVFDVQAFRSGKTPRRIVGGLKKSLVTQNSNLSCQKIKPFVFFSS
LTGTTKSTAETFVDGLITGLGKLETSQTRSFLIPELLDISNIDFYDYFLKFPNDEDAETR
NFYLFLIPTYNIDTILDNLIEHMRDIHNDFRINTAPLSSILGYSVFGFGDREGWPTEELG
FCSQARDIDKWMAKLTGGKRAFPLGMGDRKIDGKENLEKWKEGIEEVFRQIASTGNLGEG
VVGSGDADESDYEASDADQSSVNRLESSRKKSKTQSKKYDQNDLEDIGRSLNMNSSDNAP
QEVDFTTYSTKLPLITKEMVPQDSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSC
YKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWRVDPPELIYDGVKASHY
QKIKMMRGVPGVRAERFTEAMNIRHCALSLVGEPIFYPHINEFTDMLHADHISTFLVCNA
QHPDQLLSLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRDRRFEQRTVF
RLTLTKGFNMEDEVVGYADLIEKSLPCFIEIKGVTYCGNTSSKTGAGLTMQNVPFYDEVC
FFVQELDRELSRRDLNYGIAAEHAHSCCVLIASKRFQLNGKWHTRIDYDQFFRCLESGKK
FGPEDYIGLETPEWATWGRGGFDPRDERVYRKGKNKVPSSLAIKPELE
>A0A328SAR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. rholeuAM74|TrEMBL
MLISETKKKDLEKKGYRFAGKYVHSANKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PAIPYCQHKCLFCWRDTDITKTSWDSDDYDDPSTIIEDCIANQKQLLCGFFGNDNSNPQK
LKECVKPNNAAISLAGEPLLYPEINQLLREFEKRDFTTFLVSNGERPDRLKLLEDEEPTQ
LYISLDAPNEDIYKRVCKPQVSDGWSKLQESLEVLSTLDTRKVLRITSVNQLNMSNPEQY
AKIIEKSDVDYVEIKAYMFVGDSRNRLQWENMPKSAELEEFAKNVARETSFDIVDEVEKS
RVLLLGDEKPIKYNN
>A0A673C060|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
YFIPQSRKFLSYLSLGGFAKQLSEEVQTLGLTCEVIDMKEYDPDDRLADECTSRSVCVFI
VATYTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYAVFGLGNSVYVGHYNTVGKNV
DKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVKFLNRLQNLVKGDKKSCSGNC
KNGGSCKNKRKDGHGQEEEEDAVTRQNDGSEVMDGRLLSHGWCLKLNGVKKVEDEGERRE
MITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSL
ACANKCVFCWRHHTNPVGTEWRWKMDPPEKILQDSLEKHENMIRQFRGVPGVKPERYEEG
LAVKHCALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVD
ASTKDSLKKIDRPLFKDFWPRFQDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAL
GQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLL
IAHTKFKVDGEWWTWIDYERFQELVQVHEDSGGQQSFSALDYVAKTPRWALFGAEEQGFD
PNDTRFQRRNKTKDISGC
>A0A8J8D3Y4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. JdF3|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESINAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
NEDKLPSQLYVSLTAPDIETYNRVNVPMIPDGWEKIKETLGLMKDAQTRTVIRLTLVKDE
NMHNPEGYAELIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTGIGGRFIKH
>A0A2Z4LAH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. BMS|TrEMBL
MLISETKKKDMEKKGYRFSGQHLHSGNKICHWTRKSIVDDGVCYKEEFYGIKSHRCLQMS
PAIPYCQHKCLFCWRDTEITKTSWDSDDYDDPKTIIEDCIANQKQLLCGFFGNENANPKK
LDECLTPNNAAISLAGEPLLYPEINQLLREFEKKDFTTFLVSNGERPDLLKKLEDEEPTQ
LYISLDAPNKDVYRKVCLPQVENGWEKLNESLELLSTLDTRKVLRITSVNELNMLNTDEY
AKIIDKTDIDYVEIKAYMFVGDSRNRLKWENMPTTKELHDFAYDVASKAGLDVINEVEKS
RVLLLGDKLPTKYNN
>A0A836CDS3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tribonema minus|TrEMBL
MVSQRVATAAALSTTAALCVAVLVVYSSRKNTRAIRDISDIDKQRTPKAAGGGVVVPVTI
LYGSLTGTAASLADTLCKDVFALNVAGFAFHPRTVNMASYEPDDLETESVVVFILSTFTD
GAAPPTAVNMCRWLEEASVDFRVSKAQLQQLSTAVFGLGSSAYSADHFCTPARSVMRALD
GLGATAMLDMGEGDDAGDLQAQFKTWTQELLAQLCTLHADLAQQTVNEDIINDEYLLDEA
GSNVLDLEDLGTTMKSAKAEAQGREMVTPLQRKALTKEGYKIIGSHSAVKLCRWTKAQLR
GRGGCYKHTFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGREWRWKVDDPLMIVEEA
VTRHQAMINEMKGVPGVKLERWKEAFTVAHCALSLVGEPIMYPHINELVAELHRRRISTF
LVTNAQFPECIEALVPVTQLYVSIDAATKDTLKAVDRPLFSDFWERFLGSLRALRKRGQR
TVYRLTLVKGWNMAEVQNYAELIAIGAPELIEIKAVTYCGTSDASTLTMSNVPWHEEVRA
FGEALAEATGGSYGLATEHKHSCCLLLANRDKYFKGGRFHMLADAHARDGKQFSSADYMA
ETPAWAIYDAPEAGFDPVELRHYRNGKGPGADVPKYEPSESGCG
>U6CWC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neovison vison|TrEMBL
MDFVHLFVFQDKSSQERSVPKASQDLGTDGSISLQRKEVSVSGVKIFYGSQTGTAKGFAA
SLAEAVTSLGLPVAVVDLKDYDPDDHLVEEVTGKNVCAFVVATYTGGRPPHSAQWFYRWL
EEAAGDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWTLGAHRVVARGEGDC
DVANSTHGSIEADFRAWKARFLARLHTLEKGEKKPCAGSCKRGQCESSAEEEPFESTSED
ESGAEDRPNPNPVVDVEDLGRIVSCAKREKREKEQPEEKSGLLRSSGKNGPGERRAMITP
ALREALTRQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEVILKEAIENHQSMIKQFKGVPGVKEERFEEGMMVK
HCALSLVGEPIMYPEINRFLTLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTK
DSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPD
FIEVKGVTYCGESSASSLTMANVPWHEEVVHFVQDLVDLIPDYEIACEHEHSNCLLIAHK
RFKVGSEWWTWIDYDRFQELVREYEHSGGSATFGAQDYMARTPPWAVFGARERGFDPKDT
RYQRKNKSKDISGC
>R0IQI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Setosphaeria turcica (strain 28A)|TrEMBL
MALLGLLEQLPAELLLIWHEHRLPILLSALVVATIARLAIYSRDRREKLSESPAPLSPVE
KQKVELKPEWLPEHTTTISPPALNVDNHAEDDTGAVAVVAKAKKGPKTVKGRKVPKKNVA
PVPTYDHTTDKIQPLVFFQSLSGTTERYATQFAKTLTEWTAGCDQASSFLEPQIHDISYI
EHDDYFVSPPKTDANVKHFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLGY
SVFGFGDREGWPTEDEGFCSQAREVDKWMARLTGRKRAYPLGMADVKSEAEKRLQEWRIG
VQEALVEIAEGRGLGEGVPGSGDPAESDEEDVDDSEDGNGQRVDDVEDLGSMVNSSSAPI
PIDFTTYKKSTPKAKLAPAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDPPEMIFDGIT
AAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINQLLEIMHKNRISTFL
VCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRARRFEQ
RTVFRLTLVKGFNMADEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPFYD
EVAAFVTELEKELNNRGLQYGIGAEHAHSCCVLLADRNRFMRDGRWATRIDFDRFFDLCE
GKVQGSRVENEIVVGWRPEDYLGHDTPEWTLWGNGGFDPRDARVYRKGKGPKVEEVKEEE
EEDDDDDDDDEKKMMKGSAAAALEF
>F2KT41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus veneficus (strain DSM 11195 / SNP6)|TrEMBL
MDETKRPAIPQKLLKDLKGYQIVGRHSAVKLCLWLKKSLRNMGVCYKQKFYGISSHRCLQ
MTPALFCNQNCIYCWRPLELLPGIKGWDSADFIAEESIKAQRRLLSGFGGMKGVNERKLK
EAYEPNQVAISLIGEPTWYPYLDELVDEYKARGMTTFVVTNGTNPEMVERIEPYQLYISL
TAYSEESHLALNRPPRSFWDRVMESLKVMAEKDGRRVIRLTLIKGYNMNAEKFAPLIEKA
SPDFIEAKAYMHLGYSRLRLPRDAMPEHADVKAFAEELARLTGYEVKNESEISRVVLLER
E
>A0A6J0KFA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Raphanus sativus|TrEMBL
MASSSSIHARLALVALLSATTYYCIHKYRRLKRLKTLSLNPSTTTTSTSRGKIFFISQTG
TSKSLAERLHKLLESNGVAFDLVDPRSYEPEDLPKETVAIFVASTWEGGKPPKDGEFLVD
WLSESAEDFRVGSLLLSGCRFGVFGVGSRAYGEERYNAVAKEMSRRMVGLGGVEMVPVGE
GDVDDGELDREFQEWCDGVIRVLKGGSARERETNEVSQNGVVESDGEEYIDSTDEEEEDD
SNDIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
KEIVKGALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELH
GKRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKA
LQEKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGTSATSKLTMENVP
WHTDVKAFSEALSLKSKGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVA
SGELFTSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVLA
>A0A672IK70|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarias fasciatus|TrEMBL
IVRIHAQPLFVVFSVPPDSEDVSPPSQPSLLSLWHNRLYLYTAAALILGMWLSLKMVLKK
NLSSEDVSFISKVERNSHQPHKEIEVHVSGVKIFYGSQTGTAKGFAQQLCQEVKALGLPA
EVIDMKDYDPDDQLADECVSKTVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKTY
LEGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSAVRIMTRGEGDCNVVKSRSGSVQAD
FLSWKVRFLSRLQALVKGEKKSCSGNCKTGGSCKNKKRDEEQQQEEEEEEEEEEEDLMES
SSDEDESGLQERKPGSVVDVEDLGNIMSSVKKAKSREEVRVKLSKVNGVKRMEDEGERRE
MITPALRNALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSL
ACANKCVFCWRHHTNPVGTEWRWKMDPAHKILEDAVEKHQGMIRQFRGVPGVKPERYEEG
LAVKHCALSLVGEPIMYPEINAFIRLLHQQHISSFLVTNAQFPEEIRSLVPVTQLYVSVD
ASTKDSLKKIDRPLFKDFWPRFLASLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIAL
GQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLL
IAHTKFKVEGEWWTWIDYQRFQELVEAHEESGGQRSFSASDYMAKTPSWALFGAREQGFD
PADTRFQRRNKTKDISGC
>A0A2S7NP48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rutstroemia sp. NJR-2017a BBW|TrEMBL
MADETLSFRPFWAFESSGMLPICNADIVALWHLYRIPIILTTATILIIVRITLRPRALRE
KISASPLPASPTLSAVKVKEKIAPAEFDEKKSSGSKAPRRIVGGVKKRKSSDENINSRDQ
KIQVLVFFSSLTGTTEKTAQVFAESLKQNLLNANAEEESSKYTEPQLLDLSYIDYDDYFI
TPPKGDTETTYFYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSSLLGYSVFGFGD
REGWPTEEEGFCSQARDVDKWLAKLTGRKRAFPLGMGDTKTDAKDRLKEWKEGVEDVLSH
IARTGSLGEGVVGSGDAVESDVEDLEEDDDGEVLFDEQNVASRKAKTQKKDTLNDLEDIG
GGLNNTESADKEMTEEEAADLEVDFTTYSLKKAKTKAAPAVVKEMVPKSSPTYTALTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWQVDPPDMIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPYINEFTSMLHKEHISSFLVCNAQHPDQLATLQPVTQLYVSIDASNRESLRKIDRPL
HRDFWERFQRCLDILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGV
TYCGTSSSAGAGLTMQNVPFYEECLESGEKFGPEDYVGPETPEWATWGKGGFDPRDERVH
RKGKNKVPLTESQGGVKAELVEI
>A0A4C2EDE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces mellis|TrEMBL
MRPNLVTALTTVLCTGVYLWFNGRISVAFAILVFYGFLHRESSVKVEEKSQLPLSDIQEK
KKEKHTCCGGKGGSSCCSSKKGNGGSGHTCRCGSQKRKPIETQKQDVDSYPVAVDFTQAF
KPEKKKKSRQPKVFSKSMPIKKQSEMLKQDNLVKSAMTVSNETLLNSQIYIFYCTLQGAA
ERCANKVMAKLCTMKELRHRPILVNLDEITDIDDYFVNIPCENALYLMVLPSYDTDCPLD
FFLQTLEENFYDFRIEKYPLRKLVGYSILGIGDSESWPERFCYQAKKADHWVARLGGRRV
FPVGEICMKYDGENKVEDWTNLFAETLKDDEPILYEYDESVEENEGADENEEMVDLEDIG
NSDGNNSTEIKQMVAENSPTYKTLTKQGYSVVGSHSGVKICRWTKNDLRGRGSCYKHSLF
NIVSSRCMELTPSLACSSKCVFCWRHGSNPVSKNWRWEIDEPEYILENALKSHYSKIKQM
RGVPGVKAERFAKAFQVRHCALSLVGEPIMYPHISRFISLLHAKGISSFLVCNAQHPDSL
ANICKVTQLYVSIDASTKSELKRIDRPLYKDFWERLMQCLDILSTTQSHQRTVFRLTLVK
GFNMAEVMSYADLVQRGKPCFIEIKGATFAGSSDGNGNPLTMQNIPFYEEIKAFVKNFAA
ELQRRGLGYDISAEHAHSNCVLIASTKFKIDGEWYTHIDFDRFFELLENGNDFQPLDYIA
KTPEWALFGNGGFAPGDTRFYRKNKKKGPEQAESTTQQAVQTTGSIEIA
>A0A2H5VE06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon HR06|TrEMBL
MSTCYQLSRFTEDQIKRYKRAGYRIVGKNSALEICRWTKKALKGEGNCYKRWYGISSHRC
IQMTPNLNFCNYACDFCWRIHENGRYKVSNVIWDEPKEILDKMIEEQRKLLSGFKGNPEV
KREALLEALFPRHIAISLDGEPTMYPKLAELIKEIKARGMTAFLVTNGSLPYRLKELLDK
DAEPTNLYISVYGPNKEIFMRTAKPKIPNAWENLMESLKLLKHFKCRTIFRITLVKGLNM
LLPEGYSELIKMSEPKFVELKGYTWVGESIKRLKPEAMPTMEEIEEFAKEISKYTSYIIK
AKDDKSRVVVMVKNEEIWEWNLRMIREQKEKEREWDKIWRGKVKEFKTKVNLLCL
>A0A8D1MPC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKCAG
LLFSLSV
>A0A341CZS7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neophocaena asiaeorientalis asiaeorientalis|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
TTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVNHFNKVGKNVDKWLWMLGAHRVMSRGDGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKREKREKERQEGETSLIRSTVKNEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELIQEYEDSGGSKTFSAEDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A7C4AWI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MFVSEAQVRELERAGYRFLGRHRHSAVKVCHWTRKSLLNRGFCYKQKFYGIQSHRCLQLA
PGLPFCDHRCVFCWRNTDVTSPGWLGEADEPAEILDQAIAAQRLLLSGFGGNPGVDRKKF
REAQEPNHCAISLAGEPTLYPKINGLIEECRRRGMTSFLVSNGMHPEVLQRMVEPTQLYL
SLVAPDPETYQKICRPVVADGWERLRRSLEILPSLSCRRVIRLTLVKGMNLRDPAGYARM
IERSGADFVEVKAYMWVGFSRSRLSLGNMPLHSEIVSFAREVGDACGYRLVDDSEASRVA
LLSRR
>A0A6B0QYM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus|TrEMBL
MKLGELKLDGYCVYFKNKNSPEKTTPKASQNLMTNGYISHPKKEVFVSGVKIFYGSQTGT
AKGFATILAEALSSLNLPVAMINLKDYDPDDCLIEEVTSKNVCAFLVATYTDGQPPESAA
WFCKWLEEAANDFRFGKTYLKGMRYAVFGLGNSVYLSHFNTVGKNVDKWLWMLGAHRVMT
RGEGDGNVVKSKHGSVEADFTAWKTKFISRLQALRKGERKHCGGNCKKGKCESNQRGSEV
AEPGSHVQEELPHRDAEDEEPFGSTNEEESDTEDHLSSNPVIDVEDLGKIMDHVKKEKRE
KEQLEGETSAIRSTVKSEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAI
ENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINKFLKLLHECKISSFL
VTNAQFPAEIRDLKPVTQLYVSVDASTKDSLKKIDRPLFRDFWQRFLDSLKALAAKQQRT
VYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRF
VCELVDLIPDYEVACEHEHSNCLLIAHKKFKIGREWWTWIDYSRFQELIQEYEDSGGSKT
FSAKDYMAKTPHWALFGANERGFDPKDTRYQRKNKSKDISGC
>A0A1C1C8M6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cladophialophora carrionii|TrEMBL
MDMGEDAAPVILADWLDRLLTSWHDHRILLASALVLSVLAIIVRRRRAARITLRDSSPGL
EKADWLAPDEGAARTATNEKNETASIYVDQLTSGQARKPRPAAARVVTGRKPVSSRGHTS
PQRQTNPFWLQPLVFFSSLTGTTEQLSKKVAAELETLATTQSTILKPEVYDLSYIDLDDY
FISGPKTIKSAANVRYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLASLAGYTV
FGIGDKEGWPTEEKGFCSQAVEVDRWMAKLTGRKRAYPLGLGDVKSNIEQATKEWTGGVC
DVLQELRVSGTLGDGVPGSGAAVESDQEDEPDAGYDNDDDFPDSGRNKRRKLANTADLED
VGGKSAPMAIDFTTYSTTSTSASVPLKAMVPKESPTHAALTKQGYTIVGTHSGVKICRWT
KSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPKM
IFDGAKEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLHGD
RISSFLVCNAQHPQQLNDLRRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNACLDILR
AKRFEQRTVFRLTLVKGFNVEDEVEGYADLVAKGLPCFIEIKGVTYCGTSTSSSAGLTMQ
NVPFYEEVVAFVEALNTALARRGLGYGIAAEHAHSCCALIASNRFLIDGKWHTIIDYDRF
FALLQAGQDFKPEDYCKETPEWALWGNGGFDPRDERVDRKGKPIEATKADEVARGRKTKT
GTVVAVQSGGLDF
>A0A842XEW4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLGNTWTSETLQPLVPNEILRMLKNQKYHLVGSHSAVKRCRWLYEALVHDRSCYKQKFY
GIKSHQCLQMTPAVFYCTLRCRFCWRAQSGDHGLKWEETQLPNWDAPEDIIEGCVKEQLK
ILSGYKGNPKANSKKYREALTPKHAAISLTGEPTLYSHLDSLIQGFHRRGFTTFLVSNGT
VPETLSRLGEEPTQLYISVSAFDKKMFTQVCRPHIPEAWKKLNETLSLLPSFKCPTVIRL
TLARHLNLKHPELYARLIEKANPTYVEPKAYMHVGFSRLRLGFKNMPTHQEIRDFAARLA
EEMGYNILDEAQESRVVLLSRLEKPIKLA
>A0A7J2J5S5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQIKQEDRLVPDELLMALRKQHYHLVGRHSAVKRCRWLYEALINNRFCYKQKFYGIKSHQ
CIQMSPTAFYCTMRCLFCWRAQSGDLGIRWEELKLPESWDSPEEIVEGCIKAQLQILSGY
KGNPKTNLARYKEALHPRHAAISLIGEPTLYEPLGELIHEFHKRGFTTFLVSNGTLPEAL
SKLSEEPTQLYISLYGPDEKTFKMISRPQIPNAWEKINRTLELLGSFKCPTVLRLTLVRH
FNMKSPELYAKLVEKADPTYIEPKAYMHVGFSRLRLKYENMPTHREIGEFAKKLAEETGY
KVIDESEASRVFLLSRLDKPIRFG
>A0A550GTQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKNSIPSPLLLALRNQKYHMVGNHSAVKRCKWLNEALTRNRGCYKQKFYGIKSHQCIQMS
PSVFCCNQECLFCWRAQEGDLKIKYNLNKIPLQDQPEEIIKGLFKAQSSIISGYAGNNNV
DWRKLSEAARPKHVAISLTGEPTLYEFLGELLELLHKKGLTSFLVSNGTLPSRLLDLIEE
PSQLYISLCAPNREVFRRLCKPKKPGLWGRLNETLNFLSSFNCPTAIRITLVEGYNMENI
EEYAKIIDKACPTYIETKAYMHIGFSNLRLDYHRMPKYDRIQEFSSNLSKKTGYKIIDQS
RDSRVVLLSKREKPIRFN
>A0A497LNX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MRKAKVKTLENTIPQSLIETMKKQKYHFVGKHSSVKRCRWLYETLIHNRPCYKQKFYGIK
THQCIQMTPATFYCTQRCLFCWRAQSGDLQIKWNEMKFPKWDPPEKIVEGSIKAQLAILS
GYKGNPKTNQQKLREALTPKHAAISLTGEPTLYEHIGELIQAFHRREFTTFLVSNGTMPE
VLAKLSEEPTQLYISVCAPNESTYKRVCRPQIPKAWERLNETLSLLPSFKCPTVIRITLV
RGLNMENVEEYAKLIEKANPTYVEPKAYMHVGFSRLRLSYDNMPSYTEIREFAAKLSEEI
DYNIIDESEDSRVVLLSKLEKAIKFGNS
>A0A550GU26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPSTLLQVLKKHKYHLVGSHSAVKRCKWLYESLINDRACYKQKFYGIKSHQCIQMSPALF
YCTQQCLFCWRAQSGDLQIKWNEMELPNWDTAEEIAQESLKAQAKILSGYSGHPKTNWKK
FAEALTPRHVAISLAGEPTLYGHIGELIRVFHLRGFTTFLVSNGTLPSKLADLNEEPTQL
YISVCAPNEEVFKRVCRPQVPNAWAKLNETLALLPSFRCSTVTRMTLVKGHNMKHVDGYA
KLVERSEPTYIEAKAYMHVGFSGIRLDYKNMPSHEEVCDFARRLADRTGYMIIDEATESR
VVLLSKRKKSVRFASS
>A0A842P0E0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVPEELRSVYRRQGYHLVGAHSAVKTCHWVRKSLNTRGEEHCYKQRFYGIPCHRCLQMT
PSLGHCNQSCVFCWRATPEHLGVHWEQTRIPEHLADDPNTIVEGSLQAHRKAMSGFGGNP
NVSKEMLSDAMNPVHAAISLEGEPTIYPHLGELVQAYYDHGYKSVFIVTNGLNPEALANL
STEPTQLYVSACAPDEETYARTCRPLIPDGWERLNETMELLRSFSCPTVLRHTLVPKLNI
VNPAGYAKLAELSDATYLEPKAAKSVGYARQRFAYDEMAWHEDIRTFAEQLAAASGYSIL
DEQPQSSIVLLSKLKEPKKLY
>A0A550GKU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPFPLLQVIKKHKYHLIGKHSAVKRCKWLYESLIHGRSCYKQKFYGIKSHQCIQMSPSLF
YCTERCLFCWRAQSGDLQIKWNEMKLPNWDPAEEILQESLKAQTKILSGYSGHPKTNLKK
FTEALTPKHVAISLAGEPTLYGHLGELIDMFHHKGFTTFLVSNGTVPSKLAELGEEPTQL
YISVCAPNEEVFKRVCRPQVPDAWAKLNETLSMLPSFRCPTVTRITLVKGHNMEYMNGYA
ELAERAEPTYIEAKAYMHVGFSGLRLDYKNMPSHKEVQDFARCLVEKTGYKIVDEAIESR
VVLLSKHRKPMRFDTP
>A0A484DRH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bremia lactucae|TrEMBL
MPAPSAGTSLSLLLVALGVLLYFRKHPTTLFNFDVAAALLNRKKTKEPPEQFKRRGSLEL
KPVTVRILYGTQTGTSKKLAEALERTLFALNISGFHFQTSVVSMKDYDQDNLEQEAIVVA
ILSTWTHGQPPEDAKMLCSWITDMTQDFRVSKSWLNNVQHAVFGLGNAEYDEDYGRAAKN
LDRGLCDLGSSSLVTLGLGDDNVDQLKQFDIWMDNLIAAMCEYSSKIAEAALKKTRSFMK
PGKDEWLTQTEFRRQKRAKKTEVAAGNGEILKPNEEDLMNEQFLVDEFSDDEEHTKKMTE
ENNGMVDVEDIGNSMKESEAASLSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQI
RGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKG
SIERHQNMIKELKGLPGLIPERWKEAFTVRHCALSLVGEAIMYPQINEFCKQLHDRHISS
FLVTNAQFPEKIAALNPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQ
RTVYRLTLVKSYNMEGLNNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVR
AFCLALCDRVSGAYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYQRFHDLIAKYYEDGT
AFTADDYTAPTPHWAAYDSKEQGFDPVETRFRRSKDGKVVEFAYQSTESGCG
>A0A8B9YNZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus grunniens|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISHPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALCKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHLSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKVL
LVMEAWHAAIHGVAKSRTQLSN
>A0A124FHT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 40_45|TrEMBL
MDVKPNMPEEITNLFKKQHYALVGHHSSVKLCHWLKESIKNNRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPKPFDDPAFIVEESVKAQRKLLSGYWGVKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEVEVLEKMMKEN
KLPKQLYISLTAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMH
NPEGYAKLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVKNLPGYHIE
DEYPPSRVVLIMRDDLKKADRVIRH
>A0A1J1AFD1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halodesulfurarchaeum formicicum|TrEMBL
MTQQVSGPNYHTVDHTAVQTCGWTKNALRGEGTCYKQRFYGIRSHRCVQMTPVVRCNERC
VFCWRDHAGHTYELDGVDWQSPEAVVEASIDLQRELLSGFGGNDDVPDERLEEALDPQHV
AISLDGEPTLYPHLPELIEAYHDRGFTTFLVSNGTRPTVLEAAEPTQLYVSVDAPDRETY
ESVVRPREEAAWDALDESLDVLAAHDSRTTIRTTLVAGENMHDPAAYADLYRRAAPDFIE
IKGYMHVGTSRDRLDRSAMPDHEEVVDFARSVQDHLPAYDVFREAPPSNVAMLSTDPETV
VPELAE
>A0A0G4L7M3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium longisporum|TrEMBL
MPSTLSQLCGALIIGTQLCSADTLFRFNSTPEVEARSLEEIHDAALAEGGVVTLWHGGDE
TNQQDALKQAFEARFPGMTLNVTVDLSKYHDVAFDEQLANGNVTVDSIILQTVHDYPRWA
DEGALLNYAPLGFGEITPAYKDSVGASWYGMVIFFWSTIYNTKKLPGITIKEWDDYLQPE
LKNKLVLTYPNDDDAVLYAFDLVLQRYGVAWFDALLAQNPRWVRGTATPNTILSAANTTQ
AASFTSSVGYQAPTGMRITLPEQGFFVSWPQTAAIPKDAPHPEGAKLLHSYILSPEYQQL
QGWSVRRDVPLPDGFPWGALETLNSTNTAAFMDWMMDREKVGRLRDWLGRQSYNPPVCSP
SMSVPKRYHDVIDLTDDADEGGGRDETFSGAPPRKRHAPSSHPSQSSPSRGRIASSQSSS
SQRHNATSTSQSSRSPQVPQYRAPQNGRVYPSSSQHIMDDVEVIDLTQSNDEPPMEFYGS
LPTKVVGVRYYAGNASAGEIVLCNREPHNQYDSNALQVTNVLGDQIGHIPRNVAAKLAPY
LDRGEIKLECHLSGEMNFYDCPIRLRVYGPSDRDARRALEDRLKKDRIFKAAELSSSRTE
AETRRDEEARTVDFRRAGIETNAHLKARADAAELRMQQARNASKYEPPEGITMVDLVATS
ETIDVRKGADAIKTMTEEQMAAMPMADEPAFLVSKLLPYQLQGLHWMLAKEDPQLPKKDS
SDSVQLWRWQQNKRGMVNIATKFSVAGEAKLLSGGILADDMGLGKTLQVISLILSGTGSG
PTLIVAPVSVMSNWQQQFDAHVRKDKAPKIHIHHGSAASEELSGYDIVITSYGKLAKERL
EKTDSVRGPLMSVDWRRVVLDEGHTIRNAKTQAARAACQLKAASRWVLTGTPIVNNLQDL
QSMLAFLHMTGGVEQPAIFNTVITRPLTWGHKRAEALLQNIMHDLCLRRRKDMAFVDLKL
PPKTEYVHRITFRKDENEKYKVLLQEAQGVLQEYQSKARTGRVQFQSVLEKLLRLRQTCN
HWTLCRARIDDLLKVLEGQDVVILNDKNKALLQQALRLFIETQEDCPVCFDTLGDPVITH
CKHVYCRRCITKVIELQRKCPMCRQTLGMENLLEPAPEEGQDDDANAFDGETQSSKTEAL
LKIVQATCKDPQSKVVIFSQWTSFLNIIQTQIEEAGLKWTRIDGSMKPDKRDAAIAALYD
DADTKVMLASLAVCSVGLNLVAADTVILADSWWAPAIEDQAVDRVHRLGQKRPTTVWRLV
MENTIEEQVLEIQAAKRQLISKAFQEKSREKKTKETLDRGAPSLHRQSVDNPRRIFPPLR
RLTEDLVFDRILQNQTMSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQ
VTGEKPEQLKALPKKLAADETVAEKAALARDAKAEKPPVVVVAEASGAPRAPKTTSGPRR
VKGGVVRRRSSDDNVDQPPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHKAAPETRCT
FEAPELLDLAEVDFDDYFVTPPPAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFR
IDTAPLAPLLGYSVFGFGDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKT
DYAERLAEWSEGIIEILGQLARTGGLGEGMPGSGAPVESDEEDADEEDDDETLVEDGEAK
PEKLKNSKNLEDVEDLGRIMKDSRPDSVPAKGKGAPIAVDFTTHGKTAAKKAAPAPPTVK
EMVPRNSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETT
PSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRY
AEALRIRHCALSLVGEPIFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYV
SIDAADKESLRRIDRPLHRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDDEVDGY
AALVERGLPCFIEVKGVTYCGTSTXGGRSRAGPPPSRRELFPTQAEPELPELSQQRPPVL
TKHDPTATLFNPRLMRLVNATTPEVNVSSGISITTRRARLFRTTASGPTLTRSAHPMSSE
RSRISLRSGPRRKGGRPTISAPRQISEPIPQNGPSPLRNANGPASGPALRPINEAPPPPQ
QRQRPPIQPGGGNATSDLVKRRYSTRFGNFAEAGFDVNNPPVPALPTLDKYESREKRGGP
PPSRGGAAPAIDLKALRDPNLNADQYVAGLLSDATEDQIQEYQDSLRQLKARAQADLQQN
VMQNRTQFIKIAHEADKLKDEMRTLRNLMAELKANTTSLRAAAGGRNESTSLNGELSTGL
SKRDKRSSVADRSALWNSQMQALYKNVEGTQKFLPNASGRHVIQNAGQWIELDNATYKSR
RATQIFLLNDHLLIASRKKRKTDGPPREGQGNIIKLVADRCWPLLDVEVFDMAGSSESSS
TRSKLTDAIRVRGNGQESFIYRTEKPDDPDKPSLLLNIRKAVEELRKSLQSEMEANNKTK
ETINYFASRDPGLLQKAELLETLSDIKDMRIEVDGNQQNLRWVEGQMDELDIEIALQHFE
NAVERVEKLKKLARGLKSNAVAQNFINFKVEERCVKVADMLLRELDMYHNMATKTRRIVS
WLTRLGYEDRARESYLLARHNVIQHRSRQCTFQGDLHQYIWEISFCYFTLIKHTVTVYQS
CFPPPMMSTCVKWAKEEVEAFNLILSRQLSSTERDGKVWSECMDRAQKHASMLAEVGLDF
KTMVGQELREFKRSDSPIRSRYHQRSQSHRFLAAMPYNTTAIPPRKEVTGQPALPLARVR
KIIAQDPDISICSSNAAFIITEMFIQHLANEAHNQAKLDRKPRRNVQYKDLGTSSLGVIQ
YTFSRSDGPRF
>A0A0G4MHU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium longisporum|TrEMBL
MSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQATGEKPEQLKALPKKL
AADKTVAEKAALARDAKTEKPPVVAEASGAPKAPKTTTGPRRVKGGVVRRRSSDDNVDKA
AARPPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHKAAPETRCTFEAPELLDLAEVDF
DDYFVTPPPAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSV
FGFGDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIV
DILGQLARTGGLGEGMPGSGAPVESDEEDVDEEDDDETLVEDGEAKPEKLKNSKNLEDVE
DLGRIMKDSRPDSAPAKGKGAPIAVDFTTYGKTAAKKAPAPTVKEMVPKNSPTYASLTKQ
GYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGE
PIFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRP
LHRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDEEVDGYAALVERGLPCFIEVKG
VTYCGTSTASNAGLSMSNVPWYWEVCDFVKKLEARLGEKGLDYGIAAEHAHSCCILLASD
RFRVDGKWHTTIDYQRFFELLEERGPDGEWRAEDYMGPATPEWATWGNGGFDPRDDRVDR
KGRKIEAK
>A0A4U5QFS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Populus alba|TrEMBL
MTIARLARQAKRPHGFCVKMTAVAIMGFCFIFVWSMFSSSSTSATTQRESFDDIAEPVAG
NTRKDEKKINGSVSLVVNEHESRRKDRKEEASLERKEKDDGTKKLPNEGEKDNQGQEESG
DEESEKEEEEGEVVDGKKEANDGENTEGNGDIQGDGDLIQNADQESVEEVEHESAGSKST
GKKRKIKGPVFDPNAHYSWRLCSTRSKHNYMPCIDIESGTGRLQSYRHTERSCPKTPPMC
LVPLPHEGYGTPVHWPESQLKVLYSNVAHPKLAAFIKKNSWLVQSGEYLIFPQNQSEFKG
GVQHYLDSIEEMVPDIEWGKNIRVVLDIGCTDSSFAASLLDKEVLTLSLGLKDDLVDLAQ
VALERGFPTIVSPFGSRRLHFPSGVFDAIHCSGCSIPWHSNGGKLLLEMNRILRPGGYFI
LSTKHDNIEEEEAMTTLTASVCWNVLAHKTDEVGEVGVKIYQKPESNDIYGLRRRKNPPL
CKENENPDAAWYVPMKTCLHPVPSAIEQHGTEWPEEWPKRLETYPDWMNNKEKLVADTSH
WKAIVEKSYLTGMGIDWSNIRNIMDMKAINGGFAAALAQHKVWVMNVVLVHAPDTLPIIY
ERGLIGVYHDWCESFGTYPRSYDLLHADHLFSRLKNRCKQPASIVVEMDRLLRPGGWAVI
RDKVEILDPLEGILRSLHWEIRMTYAQDKEGILSHRLHNLLASNNLHFDLIDPQNYEPED
LFKEKLVIIIASTWEDGKPPQNAKFFANWLAESADDFRVGSLMLSECKFAVFGVGSRAYG
ETFNAVAKDFSRRLRDLGAKEVVGVGEGDVDGGELDGVFEEWSGRLAKVLKGESVENGED
CGNGVVVIDESDDDEDDGGVESDIVDLEDIAGKGPSRRSLVVAQSNGKLNGENGKLDGKK
EMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPS
LACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAIDLHTKMIKQMKGVPGVTLERLNE
GLSPRHCALSLVGEPIMYPEINTLVDELHRRQISTFLVTNAQFPDKIQMLKPVTQLYVSV
DAATKESLKAIDRPLFGDFWERFIDSLKSLKEKQQRTVYRLTLVKGWNTEDLDAYFNLFS
TGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALALKSKGEYEVACEHVHSCC
VLLAKTEKFKVDGQWFTWIDYDKFHDLVASGKPFDSKDYMAATPSWAVYGAEEGGFDPDQ
SRYRKERHHKTNH
>A0A7K6FS29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daphoenositta chrysoptera|TrEMBL
LDVSMDAWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPSDKLGNG
CAPPPAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLKLPVEVINMGDYDPEDGLSEE
TSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSAYV
DHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQLLCK
GEKKPCSGKCKKGKCKSSGKQSRESSDHEHGTSEHENTEAEELFETSSEEEAGGTDSVID
VEDLGNIMGHMKKAKRERELEEGAAGTGRNEEAERREMITPALREALTKQGYKLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRW
KMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALRVKHCALSLVGEPIMYPQINRF
VRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFL
DSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFVEVKGVTYCGESSASSLT
MANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLLAHSKFQVEGEWRTWIDYGRFQE
LVREHERSGGSRTFTAAEYAARTPPWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A7K4ACG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MAIDVKRTLEKQQYRMHGDHAAVKLCHWMKQSLINGRTCYKQDFYGIKSHRCLQMTPVVN
QCTHNCLFCWRVQGFEATDVQWKDPEEILDHCIEEQRKLVSGFGGDPRCSRENWEESREP
KHVAISLSGEPTMYPHLGGFIDVCHRRGMSTFLVTNGTFPEVLEKLDPLPSQLYVTVAAP
NEEIYKRLCIPRIKDGWERLNRTLEILPSLNTRKVIRHTLVKDWNMGWEKEYARLDDKAD
PLFVEPKGYVFVGDSRRRMTIDNMPSPIMIREFSERLGNELGMKLLKERHDSRVAVLGRD
ESELPIF
>A0A2E9DZZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKVLENLDTLPTQLYVSVDAP
NKEVFDNVCKPKWNSRAWEQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GHEITPIPIPEPTMFFPEDLGIAPPVKHLPIIQ
>A0A2D9G7S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDERLKARLQNQRYHLVGEHGGVKVCHWTKESLLRDRMCYKGKFYGVESHNCLQMSPVVD
QCNLACSYCWREPHMDTLELTDQDPLELLHESVRAQRRLLSGFGGNDKVNKQKLADAQNP
KHVAISLNGEPTLYRRLGEYIDECHKHGMTTMLVTNGTLPKVLEKLDPLPTQLYVSADAP
NKEVFDRICKPKWNXGAWHKFEETIDLLPSLDTRIVVRHTLIKDENMFGYEEEYAKIDER
AEPNWIEAKGYVHVGHSQNNLDITNMPYHDEILEFSNTLANLTGLQVLDDSKPSRVALIG
KEKIPLPIPEIVKQFPKDLGIAPPTKHLPLV
>A0A2E0YBY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPKLKAKLQKQRYHXVGEHGGVKTCHWTKESLLRGRQCYKGRFYGIESHGCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKAVFDDICKPKWNQGAWEKFEETIDLMPSLDTRIVCRHTLIKGKNMSHDHIREFASLDN
RADPDYIEAKGYVHVGHSQENLVANNMPTHEDIMAFSHEIAPLTNRQVLDESRPSRVALI
GTEIIPIPVPQAELYFPDDLGIAPPIKHLPVI
>A0A2E5IFE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDEVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDAHIKEFAALDN
RADPDFIENKGYVFVGHSRENLAMENMPSHDDIMEFSRKIAPLTNREVLSDSRPSRVALV
GTEITPIPIPEPTMFFPEDLGIAPPVKHLPIIS
>A0A8C5Z0T0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marmota marmota marmota|TrEMBL
PLAAWDLSSPLLSLWMHRFYLYLGFAFGISLWICVQILIKKQGKNSQERSIPEAAQDLMT
NDYASLPKKHIFVSGVKIFYGSQTGTAKGFATILAKAVTSLDLPVAVINLKEYDPDDHLV
EEIASKSVCAFLVATYTDGRPTESAEWFCKWLQEASSDFRFGRTYLKGMKYAVFGLGNSA
YASHFNKVGKNVDKWLWMLGARRVLARGDGDCDAVRSKHGSIEADFRAWKTRFISRLQAL
QKGETSCGGNCRRGKCESKQHGTEDEEPEPHALAAQQPRDTEEEEPCESSSEEEYGAGEH
QGRNSVVDVEDLGKVMDLVNKEKREEEQQEEKGLFGSRGKKEGGEGRAMLTPVLREALTK
QGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGTEWRWKMDQPEMILEGAVENHLDMMKQFRGVPGVKAERFEEGMKVKHCALSLVG
EPIMYPEINRFLQLLHQRKISSFLVTNAQFPEEIRKLKPVTQLYVSVDASTKDSLRKIDR
PLFKDFWTRFLDSLKALAEKQQRTVYRLTLVKSWNVDELQAYAELVSLGSPDFIEVKGVT
YCGESAASSLTMANVPWHEEVVRFVRELVGLIPDYEIACEHEHSNCLLVAHRRFKIEGEW
WTWIDYGRFQELVQEYEDSGGSKSFSAEDYMAKTPPWALFGARERGFDPKDTRHQRKNKS
KDVSGC
>A0A4D5RQK8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ixodes scapularis|TrEMBL
MIGIVLCIVFAAPANGREVVSEHWTSGWLPSSFATTLCGGVVMVLFFVVVREKFKFSKIQ
SDSHVKKKKKNPDGRSIKILYGTQTGNAKILSEKLLAELEALNHDVEIVNLKHIEPEECL
LGQVKSKGLCIFIVSTYVDGGPPDEAVWFYDWLKDTYADFRVHKYFLQGLDYAIYGLGDS
AFNDNYNKVARDIDFWLSKLHARRVVPLCLNDESVDEGKYGTGKFGAWKSQLLAQLRLGA
KGATQFDAPEEKPAAYETSSDEEGGGDLIDLEDLGTVRIASKNKAKAEGAAGQPKDMLTP
PVRESLTKQGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIDSHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWKWNMDPPEMILDAALESHYKMIKEFKGVPGVLRERLAEGLAVR
HCALSLVGEPIMYPEIGRLVRLLHARRVSTFLVTNAQFPEALEALGPVTQLYVSVDASSR
EALKRIDRPLFPDFWQRFQDSLIALARKGQRTVYRLTLVKEWNMEEMQGYANLVELGKPD
FIEVKGVTFCGESKGSSLTMGNIPWHEEVLSFVERLAALLPDYSIASEHEHSNCVLLAHH
KFRVDGVWHTWIDYERFHELVQRHYESGEPFGSLDYAAPLPPWATFGARERGFDPSDTRM
LRRSRKDVGGC
>A0A6V8HAA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces cellulolyticus|TrEMBL
MADSPFVPGFLATWHNFRIPIIVSLAVFFLFVRFIGSKRSKSPSSSSLPPSPRLESAIPK
EKPVASILDQTAVTEVKPTPKPVASGPKRVVGNKDRRGGKNTQKSTELSGPSFIKPVIFF
ASLTASTQTHARWLSEQLRTAAQEKSPGNDEEWGLLPPEIYDLAEVDFDDHFITAPKPPA
NSPNTRYVYCFLIPTYNIDTIIDTFIAHLDETHNDFRIDTAPLSSLAGYSVFGFGDKEGW
PTEEEGFCSQAKEIDRWMAKLTAKRRAYPLGMGDTKTDALDCLKDWTNGLAEILLEVAQT
GGLGEGVAGSGDPLESDEESAAEDEDEPSTKKSQIVVDLEDINFGASTKKSKADPIPVDF
TTVSKSQTSQTTLKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNGVKEGHYKKI
KMLKGIPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHTEQISSFLVCNAQHP
DQLATLHRVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILREKRHVQRTVFRLT
LVKGFNIDDEVKEYADLVEKGLPCFIEVKGVTYCGTSSSAGVGLTMKNVPFYEEVVAFVL
ALNNELERRGLGFKVDGKWHTRIDYDRFFELLEKEKTEGISFRPEDYMRETEEWALWGNG
GFDPNDQRVRKVRDKKPKNDQPAE
>A0A8C4EVX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
MALKKKSFPKDVGTLVYKAVKKDDRDAVVHVSGVKIFYGSQTGTAKAFAKELSEEVKASG
IPAEVIDMKDYDPDDQLADEAVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYL
KGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADF
LAWKVKFLNRLQALAKGEKKTCSGNCKTGGSCKNKRKEGHEQEEEEEEEEDLMESSSDEE
ESGLQDEKKSGSVVDMEDLGNIMSSVKKAKVRLCPPACLILLTSCYFSFCAGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKMDPAETILQDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINT
FIRLLHSHHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRF
LDSLRALGEKRQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFVEVKGVTYCGESSASSL
TMANVPWHQEVVAFVQQLTDMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQ
ELVQAHEESGGQQSFSALDYIAKTPSWALFGAHEQGFDPADTRFQRRNKTKDISGC
>R7Q3F1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp. CAG:1088|TrEMBL
MDEEYRQTLIRQHYRIYRDHAAVKLCGWMKQSLLHQRTCYKQDFYGIQTHRCLQMTPALN
ECTHLCPFCWRVEGKDFEVKEWAEPKEMLDALIDYQRLLISGFKGDERCDPVMFQEAMNP
TQVACSLAGEPTIYPYLSEFFKECHSRGMTTFLVTNGTMPERIEALDTLPRQIYVTVAAP
DKATYAKACRPKIKDGWERLMRTLELFPSLETRTVVRHTLVQGVNLMDPESYARLDRVAD
PDLIEPKGYVFVGGSRQRLTVDGMPAFETIKDFSKRIADILGMDVLREKADSRVVLLGHE
GMELDVRKAWEKGLPPSPRMDRLTADMCQ
>A0A318ZHJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus neoniger (strain CBS 115656)|TrEMBL
MADLVSVYREQGKLKEAENIWVEVFESKAEQLLSSIDLYLKRKVWAVLVSLFSVLATRLR
PSTDPVAYCDVSPGLRQPLSLLLSSRGHKGSQIPPLSHGTRLFILIHSTWRHLQTKFIFL
GLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEKRDKTISQ
STEKDVKADSKPSVVEKDASHKQAGGPKRVTGKKPLKEPPVSFIQPIIFFASLTANTERY
AQVLLEDLRAAARDRADPENRERGLLPPQIHDLSYVDFDDYFISAPKPPSTSPGTRYVYC
MLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGFGDREGWPTEEEGFCSQ
AKELDRWMAKLTGRKRAYPLGFGDVKSDADSALNEWSRGLQDILGDIVENGGLGEGVPGS
GDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDAASGSPIPVDFTTGGKT
PAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRS
HLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVKEGHYKKIKMMRGVP
GVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFLVCNAQHPDQLETLH
RVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHYQRTVFRLTLVKGFNI
DDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPFYEEIQQFVTSLNAELE
RRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEKEKADGTSFTPEDYM
RETEDWALWGKGGFDPNDERVYRKGKKKTIQAAAEAQG
>L9Y177|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema versiforme JCM 10478|TrEMBL
MSDSANPGADGASADAGDDAESDGGGPAQVSSPDYHSENHTAAQTCGWTANAMRGEGKCY
KNIFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVQWDDPEAVVDASIKLQKK
LLSGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGT
RPEMLRDCDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMDVLAEKDETRTVLRTT
LVKGENMRNPDWYAGFYQQADPDYIELKAYMHVGHSQGRLDRSAMPDHEEVVEFAEDVGE
YMPGFDEVMGVPASRVALLSKTKDTWVPKLQKGSEFWERDPVTGD
>A0A7H8QHW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces rugulosus|TrEMBL
MTESAAESGILAAWHAFRIPTIVVLTAIVLFVRFYSQPKAKTPSSSSLPPSPRLEKAVGL
EDKTRPVVPAVDAEKDQPKDKSIASGPKRIVGTRQPRGANKRQDADPSARPSFIKPVIFF
ASLTTSTERRAQWLEEELRTAAQATSKGVDTEYGLLPPEIYDLAAIDFEDHFVSAPKPPP
NSPHTRYFYCFVIPTYNIDTIIDTFLSHLDETHNDFRIDTAPLSGLAGYSVFGFGDTEGW
PTEEEGFCSQAKDLDRWMAKLTGKRRAYPMGMGDTKADPDQALKEWTTGLTEVLGEIVET
GGLGEGVLGSGDPVESDEEDTDDDEESEQKPKKSKKAQAVVDLEDINIGGSAKKRRGDPL
PVDFTTKSEKASSNQPTVKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSAMRGRG
SCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPDLIFKGVKEG
HYKKIKLMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVGMLHDEEISSFLVC
NAQHPDQLATLDRVTQLYVSIDASNRDSLKKIDRPLHRDFWERFQRCLDIIREKRNVQRT
VFRLTLVKGFNVEDEVKGYADLVEKALPCFVEVKGVTYCGTSSSASVGLTMKNVPFYEEV
VAFVEALNEELQKRGLKYGIGAEHAHSCCILLASERFYVNDKWHTRIDYERFFELLQKEK
SEGISFRPEDYMRETEEWALWGNGGFDPNDTRVRKKGKNKDKPAVEQGCS
>A0A7J9RM70|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MTMTTKEREKTLERQGYHFVGTQKHSAVKTCLWLRRSIRGEGNCYKGEFYGINAHRCIQM
TPSIFCNQMCLHCWRPLEAFTVGTEEEEVWVSAPVPVPVVWDAPDEIAEGCIKEQRRLIS
GFKGSEKTSKTAFEEASIPKHVAISLIGEPTLYPYLDELIQEFHSRGMTTFVVTNGTNPA
VLRKINPSQLYLSLNAPDEAIYRIVSQADYWSRINESLNEMGRKKSRTRTRTRTRTVIRI
TCIEGLNMVNSEGYAELLKIANPDFIEVKAYMHIGYSRRRLSRESMPAHARVRDFAREIA
EALTASGYVYTVTDESEISRVVLVS
>A0A8J4SGV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora kernoviae 00238/432|TrEMBL
MPLWSPAASAGVSLLLMATVTVGVLYYLSTHPPTSSNEAASAASPKRKTKAQRKKINKVN
TKDTNEPKPMPVRILYGTQTGASKTMAETLQKTLFALNISGFHFQTSVVSMKDYDQDNLE
QETIVVAVLSTWTHGEPPEDARMFCKWIQDMTQDFRVSKSWLSGVQHAVFGLGNAEYDED
YGTAAKNLENDLSDLGSPGLVALGLGDDNVDQFKQFDTWMDNLVAAMCEYSSERAVAALA
KSDSPVKNAQSNKKEWLSQKEFRRQKRAKKAQEAVANGESVELNEEDMMNEQFLVDEFSD
DEEQSTQNANDDSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAV
KLCRWTKHQLRGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWK
TDDAETLVKGSIERHQGMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFC
KQLHQRHISSFLVTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLA
CLEELKHKGQRTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTM
KNVPWHEEVRGFCSALCDRVSGDYALASEHSHSNCVLIAKKKFCREGVWHTWIDYERFHE
LVTKFYEDGTTFTADDYTAPTPFWAMYDSEEQGFDPVETRFRRTKDGKVVEFQYQSTESG
CG
>A0A7L2HS69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sagittarius serpentarius|TrEMBL
LDVSMDTWNLYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKSNGNP
ASSEGIEDKLVNGYATLQAKAVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVIS
MGDYDPDDCLSEETTSRNVCVFLVATYTDGQPTESAVWFCKWLEEAANDFRFGKTYLKGL
RYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAW
KAKFLSRLQALCRGEKKPCSGKCKKGKCTSPGKQSNENSDHEHGASEYENTEAEELFESS
SEEEADAEEAGGTNSVVDVEDLGNIMSHMKKAKRERELEKDVGRSLTHENTGRKEEGEKR
EMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPS
LACANKCIFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKVDRFEE
AMTAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSV
DASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIS
LGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCL
LIAHKKFKINGEWWTWINYDHFQELVREHERSGGSKTFTAADYAARTPCWALFGSRERGF
DPLDVRYQRKNKVRDISGC
>K0ILI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaera gargensis (strain Ga9.2)|TrEMBL
MSCSDEHVSHSTDNNLIQITPQLKARLQKAKYGVYNHSAVELCHWTKKSFANEGTCYKHK
FYGISTHQCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDVIVQQLMVERKKL
INGYYGNAKNDKKKLDESLLPAHYAISLSGEPTMYPKLPQLIKYLKSLKATKSIFLVTNG
QEPDMLKRLAAEDALPTQIYLSTNASNKKMFHQVNRPLHKDAWERWWESLRFLATVNTRT
VLRMTLIRGYNDSDSFVGEFAEMMAQGDPHFIELKSYMHIGMSNQRLEQDHMLEMHEVRD
FAGRLCEKMPSFKVMDESEISRIVVLQNQVRYTDRWIREYLTPTH
>A0A0U5H6Z5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium hubeiense|TrEMBL
MPKQVDDPDYHHDNHTAAQTCGWTANSLRGEGTCYKHAFYGIRSHRCIQMTPVVRCNERC
VFCWRDHAGHTYELDGVEWDDPEAVVDASIELQKKLLSGFGGNDEVPRERFEEAMDPRHV
AISLDGEPTLYPYLPELLEEFHDRGLTTFLVSNGTRPDVLAECDPTQLYVSVDAPERATF
DDVVGAQEDDAWEKLVDTMDVLHDKDHTRTVLRTTLVGGENMANPDWYAGFFDRADPDFV
ELKAYMHVGDSRDRLDRETMPNHEDVLEFAREVQAHMPEHTVLRDQEVSRVALLARDEDT
WVPKLRPDSEFWAGSAAD
>A0A6A9SCX9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. CBA1122|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRGTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>A0A8C6J827|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Melopsittacus undulatus|TrEMBL
MDMCSFFSTCLVCLWQYRLYVYCAVAFGISIWIIIQFSTSKAQKKVTEHFVPQGENPTGN
ASSSEGTEDKLVNGCATLQRKEVYVAGVKIFYGSQTGTAKRFGRALAEAVLSLHVPVEVI
SMGDCDPDDCLLEETTSKNICVFLVATYTAGQPTESAAWFCRWLEEAAHDFRFGKAYLKG
LRYAVFGLGNSAYVDHYNTVGRNLDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WKAKFLSRLQALCRGEKKPCSGKCKKGKCRSPGRQSRESSDHEHGASQCENTEAEELFES
SSEEEADAEEAGGASSVLDVEDLGNIMRHMKEAKRERELEEGDVGMSSTQENSGRKEEGG
KREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFKGVSGVQAARF
DEAMTAKHCALSLVGEPIMYPEINRFVRLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYV
SVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADL
ISLGKPDFIEVKGVTYCGKSSASNLTMANVPWHEEVVHFVQELANLIPDYEIACEHEHSN
CLLIAHRKFKINGEWFTWINYERFQELVQAREQSGGSQNFTAADYIARTPHWALFGSRER
GFDPLDVRYQRKNKVRDISGC
>A0A7G9Z7V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-1 ERB7|TrEMBL
MEPKAISNYHEATLEKQGYHFVAPHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAHRCV
QMTPCIFCNQRCIHCWRPLEAFNMGEEAVAWDTPLEIVEGCIKEQRRLISGFKGSSKTSK
AAFAEAEEPKHAAISLIGEPTLYPHLQELIQEFHSHGMTTFVVTNGTNPAVLREIHPSQL
YISLNAPDEAIYKRVAHADYWAQIQESLEVMKRMKERTVIRITGMAGTNMVDPGGYAKLL
ETANPDFVEVKAYMHIGYSRKRLTRAVMPSHTEVKEFAGEIAEHLTASGCNYKIVDESEI
SRVVLISNLSSEVKALPKK
>A0A452UJ87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ursus maritimus|TrEMBL
MSLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSQEKSVPKATQDLMTNGYISL
QEKEVFVSGVKIFYGSQTGTAKGFAASLAEAAASLGLPVAVVNLKEYDPDDHLVEEVGKN
VDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTKFLAQLQALQKGEKKPCDGN
CKRGQCESSAEEEPFESTSEEESGTEDHQNPNSVVDVEDLGKIMNCVKKEKREKEQQEEK
RSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKH
TFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMI
KQFKGVPGVKEERFEEGMVVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQLP
VEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLV
KAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVRDLVDL
IPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQELMQEYEDSGGSATFSAKDYM
AKTPHWALFGACERGFDPKDTRYQRKNKSKDISGC
>Q74MD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanoarchaeum equitans (strain Kin4-M)|TrEMBL
MLSTFSGSTKNTITRIIYKWVLHLKQVLYVDEKIKEMYEKAGYRVYKTGAVEICHWTKEA
LKNKRFCYKNKFYGIDTHRCMQISLAAFWCTNRCIYCWRPNHEFQKGHIDLLNEDWPDPK
DLLENLRKLRAELLIGFKGNEKVDKKMLEEALLPNHVTFSLIGEPLLYGRMDEAILYLKK
SWHWLKSIFIVTNGVVYETIEKLIEKNALPTQFYISFTAPNEELFFQVSKPLLNDAWKRF
NKSLKLMRHAKTRKVARITLIKGINDTDFEGWASLIEKYNPHFVEVKAFMLLGYSRQRLT
IKNMPTHEEVKEFAKKLSEYIDYDLVDEHVDSRVVLLQSNKNVIDRKIRGIEQ
>A0A665U0M4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
MLSSQQYGSTHNRVLTTVHTVFAAMLNFFPVVLLFIGHVSTSDNKVSQNEHGTSESWFMS
VWHNRLYLYSAVALVFGVWFSLNMALKKKSISKDINPWVYKAVKIQNCPDRAAVVHVSGV
KIFYGSQTGTAKGFAKELSEEVTNLGIPSEVIDMKDYDPDDQLPDECTSKSVCVFLVATY
TDGQPTENAEWFYRWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWL
WMLSGMRVMTRGEGDCNVVKSHNGSIQADFQAWKVKFLNRLQALAKNEKSCSGNCKTGSS
CKNKRNDGQLEVEKENASPQNAVAEDDLIESTSDEDESGLQDEKKSGAVVDMEDLGSMMN
IARKAKSNEEGRGDVHTVKLSKFTAVKKLADEEERREMITPALKEALTKQGYKLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHW
KMDPAEKILQDSLEKHQNMIRQFRGVPGVRPERYEEGLAVKHCALSLVGEPIMYPEINTF
IRLLHSHQISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFL
DSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAMGQPDFIEVKGVTYCGESSASNLT
MANVPWHQEVVAFVQQLAGMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYQRFQE
LAHVHEESGGLQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A497FEM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MIFIPIPREFIEVYREQGYHFIGKQACVKPCHWLRKALKTGGKYMCYKYRFFGIPSHRCL
QMTPIIQCNLRCVFCWRTHPQDIGIYDWDETKVDPRDLDDPETIAENALKEWRRVLSGFI
GSPSIPKKLIEEALRPIHVTFSLTGEPFLYPYLGELVYEFFRRGFRSVFIVTNGTMPEAM
SKLEYEPSQLYLSLYGANEEMFKLTARPLSGNLWSKVLESLELLKSFKCPTVLRLTLVKG
FNMERPEEYAKLVVKAEPTYVEAKAAMALGYFRYRLSNDAMPRHSEIRKFAEKIAEETGY
YIVDESLHSRVVLLCKFKKPIEIIPKDMHPYALSTKETEEYVESDEE
>A0A1S9DY85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus oryzae|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYVDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A2V2WQB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi|TrEMBL
MTESVSEALWWVLLGALIPLVTLTLTTLLDRWVSRRRKRQMEVARAQAAKEGKTTWMEPN
VHNSTGKTNGNGSTIHDAVKGSKGGVDVKKILIAYATQSNTACKLAHKLFSTLSTALHES
RDEMQGGSSSCVCSEGPSSCCATSHTARHLPKLKVLQLTEEGRQCGVEYLLESQAYGLVI
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKFAIFGLGDIAYGEKHFNRFA
KNLYMWCKGLGATFVVPPVYASEANTIPLFNVFAASLVKWVGRVTFTADGVTILKRQQKQ
LKEKKEKGQLKLCNDVKLQGHATYNSEEDEEDEEREEEDEENGRKKRNHNSEGDVEDVVT
DDEDEGEDVNGQSGSVDHAVRALSSEPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTK
AMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRSFRWKVDPPQLL
IAEGIAGHQKMMKQMRGVPGVTPERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHERG
ISSFMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRR
KPQRTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLTMKENVPRH
EEVVRFCAALCEALASDTAPRDKRTWLGTEPETGPLQRDLNCDEKRMSVNNMENNNRRCN
RKDEEEGVGINFSGPYGIACEHEHSCCVLIALRRFLVNGVWHTWIDYEKFNALARSGRTD
FTAAEYAAPTPSWAVFRSNEKGFDPTQVRVYRKSGNTTVVTSGC
>C0NSV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)|TrEMBL
MAGDVLQIFAQRLLTSWHRYRIPIFFLAAVVSIVIWLSTRYHKRNTPLSDSLSPCQSEEQ
NQNDKAEPCRVESPSKNDPAAAFYPNSDHSGSSIESQVRQAKQSANGPKRVHGSKPVKRG
ANNRTNPGELSRDINIQPMVFYVSLTGSTEAYAKSFCHRLQKATHALIENHSKTAILTPQ
LHDLSYIELDDYFIAAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRID
TSSLSGLAGYSVFGFGDREGWPSEEEGFCSQARDVDRWMAKLTGKKRAYPLGMADVKGDN
TQMVLNDWCDGLSGIMFDLISSGGLGEGFPGSGDPIESDEEDIRDGEENDENGQSLRNKR
KEEQIVDLEDIKFGVTDGKGTSTDRQLLPIDFTTHSHPQASKPVSQPQLEMVPTSSPTFT
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWKVDPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINEFLSLLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCF
VEVKGVTFCGTSTSASAGLTMQNVPFYEEVVAFVVALNAELTRRGLGYGIAAEHKHSCCV
LLASNRFYVNDRWHTRIDYDKFFTLLEKEKNNGISFRPEDYMRETDEWALWGNGGFDPND
TRVYTRGRNKAKLNAVLKASEQNATSVEG
>A0A1F6ZN93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon RBG_13_36_9|TrEMBL
MRTRNRKSKITATGDFKKILKKQKYFLVGEHSAVQLCGWTKKSLLNGGECYKEKFYGIKS
HECCQMSPWMKCQNKCLHCWRPIELDMKIDGKIEKPEELVENCIKAQKKLLTGFGGYKET
DKKKYKEAQEPSQFAISLIGEPTLYPGLADFILELRKQGKTSFLVTNGLQPAALKKMQDG
NCLPTQLYVSLLYPDEEMFRKITGNKEADSWKKYNETLELLKSLKTRTVIRMTLIKELNS
DEKYLEKYAELIKKASPLFIEIKSYMAVGFSKNREGMGLKKMLFHEEIKNFSEKLLKFLR
NYRFLDEKKESRVVLLGKDRERMMIKKEGI
>A0A366PUG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium dahliae|TrEMBL
MSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQVTGEKPEQLKALPKKL
AADETVAEKAALARDAKAEKPPVVVVAEASGAPRAPKTTSGPRRVKGGVVRRRSSDDNVD
QPPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHKAAPETRCTFEAPELLDLAEVDFDD
YFVTPPPAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSVFG
FGDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIIEI
LGQLARTGGLGEGMPGSGAPVESDEEDADEEDDDETLVEDGEAKPEKLKNSKNLEDVEDL
GRIMKDSRPDSVPAKGKGAPIAVDFTTYGKTAAKKAAPAPPTVKEMVPRNSPTYASLTKQ
GYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGE
PIFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRP
LHRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDDEVDGYAALVERGLPCFIEVKG
VTYCGTSTASNAGLSMSNVPWYWEVCDFVKKLEARLADKGLRYGIAAEHAHSCCILLASD
RFRVDGKWHTTIDYQRFFELLEERGPDGDWRAEDYMGPATPEWATWGNGGFDPRDDRVDR
KGRKIEAK
>A0A8C2JHR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FLILVKKDPDFSHCTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGM
RYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAW
KAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSD
AESSAEEEKSHGSVIDMEDLGNVMNRMKKTKVKTKPCRSTVVTYSLWYKLIGSHSGVKLC
RWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDP
AEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLL
HQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLR
ALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANV
PWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQE
YEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A564QD66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Syntrophoarchaeum sp. GoM_oil|TrEMBL
MLESQGYHLFGTHKHGATKRCMWLRRALRGGDMCYKGTFYGIASHRCIQMTPSIHCNHEC
IHCWRPFLDEVILEDFEWDPPSELIDGVLTEHRRILSGYGGSNKTDMERLREASVPKHVA
ISLIGEPTLYPHLPEFIDEFNNMGLTTFLVTNGTNPDMLKKVRPTQCYVSINAPDKDLYE
RVCQPKGDYWDRILKSLEVVAKMNVRRTIRLTIIKGVNMLDPEGYAELISLAKPDFIEVK
SYMHLGSSRMRLCRENMASHDEIRVFAEELASFMDGYHIEDESELSRVILISNEDSLYNR
SLDLEV
>A0A7C2QGE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSTIPAHRLSRDEIKALEKFKKAGYRIVGRHSAVKVCHWTKTALRGGKFCYKRWYGIRSH
RCVQMTPTLQYCNMMCIFCWRFHSINRVSPYSGDWDEPKAILDGCIAAQRELLSGFKGNP
KVTAQRFNEAMDPKHVAISLDGEPTLYPYISDLIKEAKLRGMTTFLVTNGTMPEVLKELE
TLPTNLYISLYGPDEETHKQVTRPLITDSWQRTIKSLELMSSLDCRKVVRLTLVKNYTMK
GAEKYASLIKLAMPEFVECKAYMHVGESQRRLPREAMPSMEEVSNFAEXLNRSLGYVLVT
EDSDXRVVLLARPDVELSKIASF
>A0A7C4WHJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MFSGVSMVTVRTYIDDVDRLRKSGYRIVGRHSAVKICHWTKNVLRGGKHCYKSWYGVESH
RCLQMTPSLQYCNMMCIFCWRFHTINRIAIYEGEWDHPEEIFDKLILEQRQLLSGFKGNP
AVDKKLFKEALEPNNIAISLDGEPTLYPYLADLIKLAHNRGMTTFLVTNATMPKRLEELI
EKDAQPTNLYISLYGPDLETHIRICRPLIRDSWIRLNESIHLMPSFEKSRKVVRLTLVKG
YNMKDVEKYAELIRIARPDYVECKAYMHVGESQKRLPREAMPSMNDIVNFSRKLSTLINY
KSLSYDMASRVSLLANESSVYYSLDSNRIAGRNYPILL
>A0A524DVW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Lokiarchaeota archaeon|TrEMBL
MKTLKTLLPKELQELLKKQKYQLVGRHSAVKACRWMRKALKGEGVCYKQKFYGIQSHRCL
QMTPTVGFCTNHCLHCWRVEPDDIAVNWDELLIEKIEDPDSPEEIVEGSLKAQKRILSGY
KPTSHQKVSWEKWNEALEPTQVAISLSGEPTLYPFLNELIELFNERKMTTFLVSNGTRPK
TIQNISEPTMLYISIYGPDKSTYFRVARPIEGKNWTHLNETLEILNSYSSNTVLRLTLVN
NLNLKNPEGYAKLIAKADPTFVEAKAYMFVGASRSRLTFEHMPEFPQIQTFAEQLAEQTG
YHILDESKESRVVLLSKLSKKINLNKN
>A0A0A1V446|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium robertsii|TrEMBL
MSAVCEKTDPLQGVFGGLPGAKFDDIVELWHGHRTPIIICALVVLVVIRIYIHKIEEAEP
LRALPKRFEKRIEPLSANKLPSAVNSEKPIAKPNGPRRIKGGITKKPATEETKEYDKSRP
IKTMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFFVSP
AKTVEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFGDKE
GWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVQEVIAHVA
SSGTLGEGAPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRMLRT
SDGNGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSIVGS
HSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHI
NEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTS
TSSNAGLSMSNVPFYWEVCEFVKALEERLKAKGLKYGIAAEHAHSCCILLASERFLVNGK
WHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIEN
VVVREAPPPDSW
>A0A485NSH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lynx pardinus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSILVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A1E2XSZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paracoccidioides brasiliensis|TrEMBL
MTGIVLGISPPGLLSLWHKYRIPILFLAPVVLAVVRLLPKYPTSDPPHSSGSSPLPSSKE
TINSGDVQERELLLSKTEPPLATLTKHDPSPSSSPDSDKRTKRRLNGPKRVHGTKPLKND
VNRLSGHARLPRDIVIQPLVFYASLTGSTEAYAKSFCDRLQGAAQSSRNNGNGTFLAPKL
HDLSYIEFDDYFIAAPNPTDSAPNTKFFYCILIPTYNIDTMINTFLDHLNETHNDFRINT
SSLSGLIGYSVFGFGDGEGWPTEEAGFCSQAKEVDRWMAKLTGKKRAYPLGLADVKDENL
QIILSDWCDGLSDVLSDLVALGGGLGEGVPGSGDPIESDEEEDIDGEPAENKTNGGNRLK
KDQEQRPIVDMEDIKFTISDEKTSADSQLLPINFTTQSRTQSFKPAAQLEMVPTSSPTHA
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWRADPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINKFLELLHGEQISSFLVCNAQHPDQLATLDRVTQLYVSIDASNRESLR
KIDRPLHRDFWERFQRCIAILREKRYFQRTVYRLTLVKGFNVDEEVVGYADLVEKGLPCF
VEVKGVTFCGTSTSARAGLTMKNVPFYEEVVSFVVALNAELSRRGLGYGIAAEHSHSCCI
LLASNRFFVNDRWHTRIDYDKFFILLQREKSDGIQFRPEDYMRETEGWALWGNGGFDPND
TRVYTRGKNKAKQNATIEESLAQGASVNG
>A0A428TXP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium ambrosium|TrEMBL
MDWANYSAPSRLDSFVEDLVDVWHIHRTPILVAALVVLGTLRIYLTFIGRKTELVALTEA
YKEPPKPKAVVEAKTPAVETIDEKKDVKPQGPRRIKGGIARKPSKKNEQEKDITRPIMVL
IFFSSITTKTDKIAQAYLKELEVKQEELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKMH
GDVDYFYTFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPT
EGEGFCFQAKEVDKWMAKLTSRKRAYPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDIAEDEDDGEVLFEDDDTSDPKKKNGRPLDDVEDLGRMIRKDD
GSTVQKAPLAVDFTYSSTKKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRWT
KSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDL
IFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHAE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLEILR
EKRNRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALEKRLKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKKF
FDLLEERGPDGDWTPEDYMDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A8J7YB46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicroarcula limicola|TrEMBL
MSESDGAKQVDDPDYHSQNHTAAQACGWTKNAMRGEGKCYKYIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQKDLLSGFGGNDEVPDDVFDQAM
EPRHVAISLDGEPTLYPYLPELIEEFHARDITTFLVSNGTNPELLAECDPTQLYVSVDAP
DRKTFDSTVKAVEDGAWESLIDTFDVLAEKDETRTVIRTTLVNGHNMHHPEWYAAMCDRA
NADFVEMKAYMHVGHSRGRLDRDSMPDHSEVRAFTEAVGEYLPHDVLKEVEESRVAVLAE
DEQTWVPKLKKGSEFWERDALVEY
>A0A2D6SP84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MITADVKLMLKKQHYEVVGNHTRVKVCHWTKSELRGQGGCYKKKFYGINSHQCIQMTPTF
VCNNACVFCWRDLRYHTQPAMEGDIDNPSDIVEGTLEAQRKLLTGFGGNDSTSKEMFEQS
KEPQHVAISLDGEPTLYPRLAELIKEYKKKNFSTFVVSNGLMPERIEKLLEEPPTQLYIS
VDAPNEELFNIIDRPIIKNAWQGLYKTLSILPKIGENTRIVLRFTLIKGMNMIYPEQWAG
IIKLSNPMFVEVKAYMWIGMSRERLEQANMPLHNEVNEFAKEIAKHAGYKVIDEHEPSRV
VLLMKQDFEGRVMKFD
>A0A251VFR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Helianthus annuus|TrEMBL
MSSTTTTTTSLTTHLTLLTLLSATTLYCFYKSRRLKPSPPSPNPTTRPGKLFFISQTGTS
KALAKHLHNLLISNNLPFDLVDPKTYEPEDLHNETLVIIIASTYENGNPPSNGVFLSDWL
SESVEDFRVGSLLLSKCKFAVFGVGSRSYGDMFNKVGKAFSTKMRALGGVEIVPFCEGDV
DEGELDSEFGVWSEKVVRVLKTGEINELVAESCEEFIDESDYDEDEEEEEVETEIVDLED
IAGKSLKKKDMGMVTSNGKKNGEKVMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLMIVNTA
IEEHRKMIKQMKGVPGVTAERLSEGLLPRHCALSLVGEPIMYPEINSLVDELHKRRISTF
LVTNAQFPDKIVSLNPITQLYVSVDAATKENMKAIDRPLFGDFWERFVDSLKALKDKQQR
TVYRLTLVKGWNTEDIDAYSSFFSIGNPDFVEIKGVTYCGTSATSKLTMENVPWHADVKA
FSEALAEKSNGEYEVACEHVHSCCVLLAKVDKFKINGQWHTWIDYEKFHDLVASGKPFGS
NDYMALTPSWAVYGANEGGFDPEQARYKKERNHKSSR
>A0A2P9D7C9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium reichenowi|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINEIINKNIYMNNMNGNIHYDDILQKKDYIEKKIQINESYKNNDNVDHSNIDGNIIHK
NNCVNNWLDIKDMNSLENEIIEYFKLRFDKYQVNNKKRKEKISRSNYENMVPLYYNKNIN
YLEPYEENVKMFNSKFKNYIDCTIDNKNIGKIYFNLIDANNHDYYSFFDNTENYNLNVLF
FFISTSSYGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPI
KKCEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYCFNYMKRWYMN
KRIYDTLSYYCYFFSNYTNFNVNETEQIKYYMHDQKSESEKKKKKKKKEKEKGDLSIYPM
EQLEACHCNKPYQENDLSIDQSNINYNNNKCCNNEIYNTHNDIYDNDKDDHQISLSNMGN
DEKDFVNEHKTKVDKTNGMMNEKREEVYVRGDTQGVQGCTNCNCQSVNEYNDTSNTNIMN
NKNNMNNKNNVNNKNNVNNKNNVNNKNNMNNTNNVNNKNNVNNKNNVNNPNNIMTGENSM
SESETSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRW
TKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAE
IIVEEIIKKHKAMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHK
RNISTFLVTNAQFPVELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKIL
KNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNI
PWHEEVYQFAWNLINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQ
LVKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A7J3WMJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MKESTLELLRKQRYQLVGDHSAVKLCHWLKESLMRDRVCYKQKFYGIKSHRCLQMTPAVN
WCTQKCLFCWRPVRFTEDVPPDVDAPKYIVEESIEAQRTLLSGYQGVLDRVNKKKLEEAQ
TPNNVAISLSGEPTCYPLLPELIEEYTKEGFTTFLVTNGTNPDVLRDMDPLPWNLYVTLP
APSKDIYQRLCNPTIPDGWERINETLELFESLDTKKVMRLTMVKGINMVDPAHYAQLIEK
ASPTYVEVKAYMFVGFSRARLTIEHMPRHEEIREFADSIAAESSYRVVDESPESRVVLMS
R
>A0A6A6PSP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neohortaea acidophila|TrEMBL
MLALPSELLLLWHEHRIELLLSAGFFLACVRVAIHRRQRPAKPELSSPSPLVVDIKAPQT
VKDVLEKPVEPSPRLSTTSAALKPSSGPRRVKGVRKTKASSPEGRQSAAFDTIEPHIFYF
SLSGSTKSFAQHLHQSLLQSSDDLLLPAVLHDLTDIDYDDFFIAPPKTPHPRAAPFYLLL
LPTYDISTELDNFLSNLQETHHDFRIDTHPLSGLAGYSVFGFGDKHEWPSEDAGFCTQAV
QVDKWMARLTGGKRAFPLGTADVKSGAETSFEEWSVGLNTAFTDVAAAKGLGLGVEGSGD
AVESGSEDDDDDAGIKPPRTGDLEDLKAPVPIDFTTAKAIVKPMVPTTSPTYAALTKQGY
TIVGTHSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTN
PVSTTWKWTVDPPDEIFVGLKEGHYKKIKMMKGVPGVRAERFQEAMTIRHCALSLVGEPI
FYPHINELLAMLHKEHVSTFLVCNAQHPDQLAALGPVTQLYVSIDASNKESLKKIDRPLH
RDFWERFLRCMDILREKRFTHRTVFRLTLVKGFNIEEEAEGYADLVQRALPSFVEVKGVT
YCGTSTAAGAGLTMRNVPFYEEVSAFVLALEAALLKRGLQYGIAAEHAHSCCILLADKTR
FFRSDETDTTERWHTLIDYPKFFKCLESGEQFRPEDYVGAATPEWALWGNGGFDPRDERV
DRKGRKIEESKE
>A0A811MKS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Miscanthus lutarioriparius|TrEMBL
MPPFPAATTASTTSHLALLVLLSSSSLFFLYKSFRLRRKPSPATAHARTATPTLLYASAT
GTSKTLAERLSARLTADAGFPVRATDAATFDPDDLPSVPLLLLVIPTHDGGAPPPSAAFL
SRWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVEVVPLG
EGDMDGGDLEAVFEEWSWRVLRVVKGEEVGYGANEKSNGLDELELEGEDWDDDDEEEMVD
GEVDMEDIAGKAPARRKNGNSEGVPANGNLEGVLANGAQNGVKDMVTPIIRTSLEKQGYK
IIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGKSWKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIM
YPEINALVDELHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAIDRPLFS
DFWERFLDSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLDLGQPDFIEIKGVTYCGS
SATSKLTMENVPWHSDVKEFSEVLASNSNGVYEVACEHAHSCCVLLAKVGKFKINGKWHT
WIDYDRFHELVTSGKPFKSRDYMAMTPSWAVYGAEEGASIYGSLPEVYPSQRKAHHSQMK
HIFKIAAILVAISAIWIALLETSTVPRSYTWLLPIYLVVALGCYGLFMVGFGLMFFPTCP
QEAVLLQQDIVEAKEFLAKKGVDVGSE
>M7T190|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eutypa lata (strain UCR-EL1)|TrEMBL
MTTLTSKDLDAILDLPYLQELTLYALYEESWENPRSDGDYFNTQLAKRAKHKLNRLAITI
IQNLMIRSRWDLFGPRRYLHCIADFTVLRELDVDLLVLVAHRGNMKNVQLEARLPASLRK
LTLREQWRLEPPKRRRPKCFGTKYAKDRADMMRRFARSCKARCADLTTVHWVAWQTKEGD
EIVSGWDLETYSELVGLFAAANVAFECAVARRRLEWNILELWHNYRASILGAATCLLLAI
WLYLQLSQRKEKRPSSPKLELGKSTVVELKSEEKISLSKPKETSSGPRRIKGELRKPDRS
KPVVKRDHERQVQVLIFFSSLTGTTERTTKEVARSLETSLLEQSPENGHVFLKPQVLDLT
EIDYDEFFISPPKPAEEGSQVDYFYMLLLPSYNIDTINDTFLEHLKETHNDFRIDSASLS
GLLGYSVFGLGDREGWPSEEDGYCFQAKEVDKWLAKLTGRKRAYPLGMGDPKQDLKERLI
EWTEGVRDTVRHIAKTGSLGEGVRGSGDAVESDDEYISEDDDDGEVLIDESALPKKTKQK
STRDLEDVEDLGKIMKTSRAETAASKGSTPIAVDFTTYGKTSKKSPQTVVKEMVPKSSPT
HAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIHSHQCMETTPSLSCSNKC
VFCWRHGTNPVGTTWRWVVDPPDLIFQGVKAGHYQKIRMMRGVPGVRSERFAEAMRIRHC
ALSLVGEPIFYPHINEFLGMLHAERISSFLVCNAQHPDQLAALGPVTQLYVSIDASNRES
LRRIDRPLHRDFWERFQRCLDILRARRFRQRTVFRLTLVKGFNVDDEVDGYADLVEKGLP
CFVEVKGVTYCGTSNGGKDGKDGLTMANVPFYAEVAAFVEALNARLNDRGLGYGIAAEHA
HSCCVLLASDRFRVDGRWHTRIDYERFFALLEERGPEGEWSPEDYMGEATPEWAAWGNGG
FDPRDERVDRKGRKKVVEI
>A0A3B4DMY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pygocentrus nattereri|TrEMBL
MSGTLDGAWTCTEAWLLAAWQNRLYVYSAAAVLIGLWFTVNMALKKKKLDVPESHRLDKP
EKKKEQLPEKEKAVHVVGVRIFYGSQTGTAKGFARELAQDVCAAGFQSEVIDMSDYDPDD
RLSDECTSKMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAAFGLG
NSEYVGHYNTVGKNVDKWLWALSASRVMGRGEGDCNVVKSRNGSVQADFQAWKTKFMSRL
QALARGEKKTCSGKCKKGSCKNKKKHQQGTEEGHPSPEKHSSEELFESSSDSESAAEEEK
EHGSVIDMEDLGSVMSVIKKAKKQGEEEHRGKLSKLNGVMKTDVEEERREMITPALREAL
TKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDPAEKILKEAVENHQNMIRQFRGVPGVRPERFEEGLSVKHCALSL
VGEPIMYPEINSFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKRI
DRPLFKDFWQRFLDSLGALGEKQQRTVYRLTLVKAWNVDELKAYAELIALGQPDFIEIKG
VTYCGESSASSLTMANVPWHEEVVHFVQQLADMLPDYEIACEHEHSNCLLLAHHKFKVDG
EWWTWIDYERFQELIQQYEESGGTMTFSALDYVAKTPGWAVFGARERGFDPSDTRFQRKN
KTKDISGC
>A0A8A2U5R7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena longa|TrEMBL
MSDSANPGREGASADTTTDAADGDGSGAAQVSSPDYHSENHTAAQTCGWTANAMRGEGKC
YKNIFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVQWDDPEAVVDASIDLQK
KLLSGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNG
TRPEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWENLLETMHVLAEKDDTRTVLRT
TLVKGENMHNPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSAMPDHDEVVEFAEDVR
EHMPGFEEVMGVPASRVALLSKTKDTWVPKLQKGSEFWERDPVTGD
>A0A8H7W1K4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thamnidium elegans|TrEMBL
MSNFINSLLYGFTNILSVGPEEPKEGDSAGCGSEQGCCKDQPKVKQACQNEAADACCSSS
SEPKQNTGCCSSSSEPKQETGCCKDNTVKSETKDTCCQSSDTGKEACACEGEKEPVVIDH
LKIIFSTLTGTAKTMASEIENKIRQNDRVTVNKVDIMDITEYDNDNLLQETAICVFILST
YNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYSVCGLGDSAYGDEFNVAAANIDKWLGR
LGATRIYPLGECDKNADQKGQFDTWSNGFVSELEDKQCLEFSPTDISYQSDEEEDEASGE
ENGEIDIEGSGDEMVDLEDMGNMASKIKAAKARRAEEEEDYENSKAKAKRMIGVDDNKPR
EKASAPQAREMVSPMIMKNLTKQGYKVIGTHSGVKICRWTKSALRGRGFCYKHAFYGIQS
HLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQLKGVP
GVKAERFQEAFTIRHCALSLVGEPIFYPHINDFVTMLHKKRISSFLVTNAQFPDKIAEMV
PITQLYVSVDAATKETLKKIDRPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAE
IDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCQKLVSKLGGDYEI
SAEHAHSCSLLIAHKDFKVDGVWHTHIDYNKFFELVESGKPFNSLDYMAKTPEWALHGHE
AAGFDPEETRFYRKNRKVVAAPENPDINA
>A0A2R6GSI5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_6_64_34|TrEMBL
MSDSDSGGPKQVSDPDYHSQNHTAAQTCGWTANALRGEGKCYKYAFYGIESHRCIQMTPV
VKCNERCVFCWRDHAGHAYELGDVAWDDPAAVVDASVELQRKLLSGFGGNDEVPREVFDQ
AMEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTHPEMLARCDPTQLYVSVD
APDRKTFDSTVKAVEDDAWHNLIDTLDVLAGKDDTRTVIRSTLVRDHNMHHPEWYAAMCD
RADADFVELKAYMHVGHSRGRLDRESMPSHEEIVAFAEEMQSFLPDHDTMKDVEPSRVAM
LARESDTWVPKLQKDSEFWADDPLAEY
>A0A8C6TDV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neogobius melanostomus|TrEMBL
KSVPSATNPLPQPVKSSDSAKDTVAHVSGVKIFFGSQTGTAKGFAKELLDEVEASGFPCE
IIDMKDYDPDDQLADEGTNKTVCVFLLATYTDGQPTENAEWFCKWLEEASTDFRYGKTYL
KGLKYAVFGLGNSVYTGHYNTVGKNVDKWLWMLSAARIMTRGEGDCNVVNSKHGNIQADF
KAWKMKFMNRLKKLAKGDKKSCNGKCKSGGSCKNKTKHEHGHEERSEHVIQTVNAEVNET
FNLKDRHLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIREFKGVPGVKPERYEEGLAVKHCALS
LVGEPIMYPEINVFLRLLHSNRISSFLVTNAQFPREIRNLVPVTQLYVSVDASTKDTLKK
IDRPLFKDFWPRFLDCLKALGEKKQRTVYRLTLVKAWNVEEMLAYADLIAMGQPDFIEVK
GVTYCGDSTASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFNID
GEWWTWIDYERFQELVQAYEDSGGEQTFSSLDYMAKTPTWALFGAEEQGFDPTDTRFQRR
NKAKNISGC
>A0A8C6WMZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neogobius melanostomus|TrEMBL
MQTLAIIVLPLSSAASTSEDRESHGPVLSYITSIWHNRLFLYSAAALIFGIWFSVKVLQK
KSVPSATNPLPQPVKSSDSAKDTVAHVSGVKIFFGSQTGTAKGFAKELLDEVEASGFPCE
IIDMKDYDPDDQLADEGTNKTVCVFLLATYTDGQPTENAEWFCKWLEEASTDFRYGKTYL
KGLKYAVFGLGNSVYTGHYNTVGKNVDKWLWMLSAARIMTRGEGDCNVVNSKHGNIQADF
KAWKMKFMNRLKKLAKGDKKSCNGKCKSGGSCKNKTKHEHGHEERSDFSLSQILFCIYHI
QEDLFESSSDEEESGLQDEKKGPVVDMEDLGIIMNGVKKAKVKLYTNLLYNIVMHLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEW
RWKMDPAEKILQDSLEKHQNMIREFKGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEIN
VFLRLLHSNRISSFLVTNAQFPREIRNLVPVTQLYVSVDASTKDTLKKIDRPLFKDFWPR
FLDCLKALGEKKQRTVYRLTLVKAWNVEEMLAYADLIAMGQPDFIEVKGVTYCGDSTASS
LTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFNIDGEWWTWIDYERF
QELVQAYEDSGGEQTFSSLDYMAKTPTWALFGAEEQGFDPTDTRFQRRNKAKNISGC
>A0A8J2ATA1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amoebophrya sp. A25|TrEMBL
MSRSSSSMDRTWAAWASLSVAGAAATGTALYLHWRRRRDAEILLEQEKQREKQSGEDEVL
RSSNRQDHERPTVQASRPPEDTSLTPGSSSEGITSPDHGPQSQEQLEMRRTLVLFGHSNS
LSERLATIAAMALGTVGAKRSAGEDDDEVPLFNRVTRETVKLAPRTSDVPAVQLTRFDQV
DLEDFAFFDQIVFVLATFDDGPPEPARVLCEQIGEAAVDHRFGSATLRHLGSGSSACSSS
TARVLVVGLGDWNYGRELYCSEAVRLAENLKKLGATKLRLEKVDSASYLDDEESSSTTAP
AEKEPTATPLERMERLVIQTVVQSLLSPTAAVNEDSVESREGANEEPSGCCQGGGGSSSG
GGCCQSSSSSSGHKNSAAKSPSSASTTLPGTPDGQTVDKPGGETFSESETESEEYSDSDE
GDSDAEMFGSGQNDAANKDPLFVQEDVEDFLTENAQSSCSSGTTVGAAKNGKQGDATAAA
PVKKKKMLSTRQRENLAKEGYKVVGQHSAVKLCRWTKHHLRGRGGCYKHTFYGIASLSCM
EATPSLACANKCVFCWRHHKNPVAKRWEWEMDEPKLIVENWLAEHAKMVKQLKGVPGVTP
ERFEQAKKIRHCALSLVGEPIMYPKINELLHLLHKEKISTFLVTNAQFPDELRALGPVTQ
LYLSIDAPTRETLKAVDRPLKEG
>A0A4P9TEN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema pallidum|TrEMBL
MSDSANPGADGTSGDATAEGDGGGPAQVSSPEYHSENHTAAQTCGWTANALRGEGKCYKN
IFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVAWDDPEAVVDASIDLQKKLL
SGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRP
EMLRDCDPTQLYVSVDAPERHTFDQVVGAMEDDAWENLLETMHVLAEKDDTRTVLRTTLV
NGENMHNPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPEHEEVVAFAEDVREHM
PGFDEVMGVPASRVALISKTNDTWVPKLQKGSEFWERDPVTGD
>M0A3Y6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba hulunbeirensis JCM 10989|TrEMBL
MSDSADAGVDGEVGADADADADSGTDGGNRDGGPAQVSSPNYHSENHTAAQTCGWTANAL
RGEGRCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDGVEWDDPEAVVDA
SIDLQKRLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITT
FLVSNGTRPEVLRECDPTQLYVSVDAPERHTFDQVVKAVEDDAWDRLLETMDVLREKEET
RTVLRTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVVE
FAESVADYMPEFTECKGVPSSRVALLSKTSDTWVPKLKKGSEFWARDPVTGD
>Q971U7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)|TrEMBL
MVSNLRIDTLSLIMKELEKEKYHIVGNHSVYKKCHWTHEALTSGRYCYKGKFYGIESHRC
VQMSPTAAWCWFRCIHCWRLEPEDIGIEWDETKLPVEDDPDIIVEKSIEEHKRAVSGYFG
REGVDKNKVKEAITPKHVAISLTGEPTLYDRLGELIKEYHKRGLTTFLVTSGVRPDILAS
LEEEPTQLFVSLQAPNEFKHKLINRPIVANSWNLVMKTLEILPSFSSPTVIRMTMIKGFN
MSDEDAREFARLMEIAQPTYIEVKAYMHVGPSTYRLSKDAMPRHFEIKEFAKKLAEYTGY
KILSEHIPSRIVLLSKLDKPIQIGNAWTDNWNWATKDIEDDINGEYKEAELGCTEGET
>B8GJL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)|TrEMBL
MHSDPCESLRRQGYQFFSPRSSAAVKPCLWCIRALKGGEMCYKHQFYGIESHRCVQMTPT
LKCNQRCLFCWRSFEHEVEEETECTPEEILAGVARLQLKGLAGYKVSPDVTAERFDQAIH
PRHIAISLAGEPTGYSRLPELIDLFSGEQYTTFLVSNGTRPWVLRKCKPYQMYVSLDAPN
EAIYKRLCQPRGDYWELVQESLSLLGSRRSAIRITLVAGINDTDPAGFAAMIADAAPTYV
EVKGYMYLGSSRNRLQQGHMPDHQKVRGFAEQIGRYAGYTIKDEHPGSRVVCMERAR
>Q0UIA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)|TrEMBL
MSLLDGLAQLPAELLLIWHDHRVPILFSAIALAAIVRLAIYARGRRDKVSASPLPGTPIE
KKKIELRPEWLPENTTFNASALNVDGHAEDDTGAVATVAKIKKGPKTVKGKKTPKKTGVP
APSFNHTTDKIQPVVFFQSLSGTTERYAKEFAKVLTEWTTGCDQASSFLELQLHDISYIE
YDDFFISPPKVDANVKQFYIILLPTYNIDTVLDNFLENLQETHNDFRIDTAPLRSLLGYS
VFGFGDKEGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMGDTKTDAADRLQEWRLGV
QEALVEIAEGRGLGEGVVGSGDPAESDEEEDIEDGTGQSTRVDEIEELGSMVDSSSTPIP
VDFTTYKSKSKPLVKSSAAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDGIT
AAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLEIMHSNRISTFL
VCNAQHPAQLASLVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGDAGLTMQNVPFYE
EVAEFVTELEKELSSRGLTYGIGAEHAHSCCVLLADRTRFMPNGKWATRIDFERFFDLYE
GKVEGTRVEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDQRVYRKGKGPKNDEEGDGG
KVIEIKAKNEALEF
>A0A1D1ZLF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anthurium amnicola|TrEMBL
MTTASPLTSLPARLALLTFFSLSSFFFLYKSRRLRQLRLASLPTPSPRDGADPRGKLFFA
SETGTSEALARRLLRLLSSEGLAFDLVDPSGYEPEDLQKENVVLMVASTWEDGRPPPNAE
FLARWLSESAEDFRVGSILLARCKFAVFGVGSRSYGEGFNAAARGFSRWMRALGASEILP
VGEGDVDAGDVDEVFGSWSTKVVRLLKGDLHEKDRRPGLNLENGTLEGSEEEEDYDEDEE
ELESAMADMEDIAGKGPSRKSSAASRNGDVTGEKKLAANGDLNGVKEMVNPIIRMNLERQ
GYKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWQWKMDDPLEIVNAAIVQHTKMIKQMKGVPGVKEEQLLEGLSPRHCALSLVGE
PIMYPEINTLIDELHRRRISTFLVTNAQFPEKIKTLKPVTQLYVSVDAATRDSLKAIDRP
LFGDFWERFIESLKALRDKEQRTVYRLTLVKGWNAEDIDAYSNLLDIGEPDFIEIKGVTY
CGSSATSKLTMENVPWHSDVKDFSEALAEKSNGVYEVACEHVHSCCVLLANVKRFRIKDQ
WYTWIDYEKFQDLVGSEQTLRSEDYMAQTPSWAIYGAEEGGFDPHQRRFKKERRHGNTNS
RTLLI
>A0A075FZ19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine group II/III euryarchaeote AD1000_80_H11|TrEMBL
MGCGVGGECMQSPITRIEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLINDRSCYKGTF
YGIESHGCMQMAPNVDTCNLACTYCWREPHSDTLHKIDDDPYELFLESVRGHRRLITGYG
GNPKADPEKFREAQNPKHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIE
KLDPLPTQLYVSVDAPNKEIFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKG
ESLGHHEDYARLDNIADPDFIEAKGYVYVGNSRNNLTIENMPYHQDILDFSNRLAPLVGR
EVLSDRRESRVALIGREMVPITLPEKVRELPKNLGIAKPQQYVLPQA
>A0A0G4IID2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodiophora brassicae|TrEMBL
MTGDDAVLILYGTRAGHARRVALKLQAELHRAGKISSMRSMAKFDPEDLVSHGRVLAVMS
TDSGGMPPPDARFFCQWLRDAVEDVRVPGDYLSGTRFAVFGLGDRAYEEQFNLAALNLDE
SFLKLRGRQLTAPFLSDGTDDDGDVSRWVKAVCIALDDAADGTAAADEAADDVVDVEDMG
SMMSTPTEGPGGRRPEMVTSRVRSNLAKQGYKIIGSHSGVKICRWTKAQLRGRGGCYKHT
FYGINSYQCMEMTPSLACANKCVFCWRHQTNPVGTSWRWAMDDPREILDGAIDRHCRMIN
EMKGVPGVLPDRLAEAYTVRHCALSLVPGETDAQYDHAAILVTYRWSQQEINTLLGMMHE
RKISTFLVTNAQFPDLIQTLRPVTQLYVSIDAADKDTLKAVDRPLFGDYWDRFLGSLDAI
RESKQRTVFRLTLLKGYNMDDVARYAQLVARGAPCFIEVKGVTFCGAGETSELTMKSVPF
HHEVKSFCEALCREIGDDQYDLACEHEHSCCVVIGHTKFKVDGVWHTWIDYDRFHELSQS
GDAFSPTDYACPTPSWAIYNNDEKGFDPNDTRHYRNRHRARPTERDTDGAAVFTPSPSTR
PA
>A0A7C4S9E3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethyliaceae archaeon|TrEMBL
MSEIKKLIIDDEVRQKLKKAQYGVFGHSVVDICHYTKKALKREKVCYKRKFFGIETHRCM
EFSPAGLYCHNRCIYCWRPTEFYETIKMEEDEVDEPKDIIENLLKIRNQLLIGFGGNEKV
VKELYEEAKIPSHFAISLMGEPTLYPKLPQMIRYLKSLPSTKSIFLVTNGQEPEMLERLE
KENSLPTQLYLSMNAGTVETFKKVNVPTLSDFWERFNRSIEFISKTKTRTVIRITLIRGL
NDNIEEIADFAKLITEANPNFVEVKSYMHVGYSKSKLKEENMVTVEEIKRWVSKLLLHLT
NFEYMDEDVDARIIIIRNKEREVDRWIIRPEESTLYKYGL
>A0A0D9ZDT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza glumipatula|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQVPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGFTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQDSLKSLHDKDQRTVYRLTLVKGWNAEEI
DGYAKLLSLGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKDFSEALALKSGGVYEVA
CEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELVTSGKPFRSQDYMALTPSWAVYGAE
EGGFDPDQSRYKKERRHGAAALKD
>A0A7D5KCR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena sp. YPL8|TrEMBL
MSNSANSADGATADTTADAASDGDDDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGK
CYKNIFYGIESHRCIQMTPVVRCNERCVFCWRDHNGHAYEMDDVEWDDPEAVVDASIELQ
KKLLSGFGGNDEVPREVFDQAMEPRHVAISLDGEPTLYPYLPELIDAFHDRDITTFLVSN
GTRPEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWENLLETMAVLADKDETRTVLR
TTLVDGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSAMPDHEAVVEFAESV
GEHMPEFTEVKGVPASRVALLTKTTDTWVPKLKKDSEFWERDSVTGA
>A0A559M054|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachnellula willkommii|TrEMBL
MDHDTWSPRALWSPYATDIFALWHTYRIPIILSTFAVLLTIRTILHLRVNRKRVSDTPPP
ASPTLQAAKEKGPVEYLEKKTNSEKVPRRIVGGLKKKQSSEENVVLGEKKIQVLVFFSSL
TTTTEKTAKVFTEGLAQCTKDIANSTSIIFLEPEILDLSYIDYDDYFINPPKSDPGVQYF
YLLLIPTYNIDTVLDNYLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFC
SQARDVDKWMAKLTGRKRAFPLGMGDPKTDAVERLREWKEGVEDTLRHIAETGSLGEGVA
GSGDAVESDVEDVDDEDDVLFEEQKVAKRKTKEKKGDLNDLEDLGGSIPKAEDEALEVDF
TTYSKKPSTTTPTIKEMVPKNSPTYNSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYK
YSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPDLIFSGVKAGHYQK
IKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHAEHISSFLVCNAQH
PDQL
>A0A843CEM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis sp|TrEMBL
MSCSGETVEPENDIIQIKSSIREQLKKAKYGVSDHSTVELCHWTKKSFKNEGSCYKHKFY
GISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLEMDASKVASPEEILAKLMKEREKLIM
GHYGDPKSDIKKLDESLLPSHYAISLSGEPTMYPKLPDLIKYLKSLKATKSIFLVTNGQE
PDMLQRLSDEGALPTQLYLSTNAADYNSFIKINKPKYKDSWERWNRSLEMLSNLDTRTVL
RVTLIRNYNNSDEMIPAFSEMVKKANAHFIEIKSYMHIGRSTNRLERSDMLEYEEVMHFS
SELARQSQIYSIMDDSQVSRIVVLQNNQRFIDRWISAYA
>A0A251RAC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus persica|TrEMBL
MSLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSSSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNGLAFDLVDPNHYEPEDLPKESLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGASEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNGVGAECEAESFDGSDEDEEEEDDVESEV
VDLEDIAGKGPSRRRTVTVTKTNGTVNGQKEMVTPVIRASLVKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPL
EIVNSAIDLHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHR
RRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSL
KEKQQRTVYRLTLVKGWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPW
HADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSS
GRPFDSKDYMAATPSWAVYGAEEGGFDPYQSRYKKERHHRSNQ
>W7AKH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vinckei petteri|TrEMBL
MVTKREDELVPPPNEGGNVNIYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIVFFND
ILNHFNTISTITKGDKTNGTIFDGSISNEINNIEDYMLEYFQSKLLKTNKKNKDRKFGKN
CKNEKGNITNNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCSIENNISEIHFD
FVNGNEFDSYTFFENSENNDLNILFMFISTYNFGSFPANCYKLEDTLTDLVNDFRVEKNY
LKNIFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLKLCSTMDNEEEFVHWK
SSLLKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSDDPKSMPINNDE
NKQTNKPVNNNNINKCDCISNGIPSEHLNTPKELGNDHNELTNKANGHISFSTSKIDTSN
TEKCGCTSNNCLNGNDKYINEKKIINNNFETSIVNGCCKNEYEQDDELVNSDFSNESMIE
NNDEINCNSSEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQIRGR
GGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVK
KHKNMIKELKGVHNVINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLV
TNAQFPNELKKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKEKKERTV
FRFTLVKEYNMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQ
FAFHLVNSKRSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNF
TAIDYCAETPEWAVVGAPECGFNPSDQRVYTKGKNKKKNNINTMEVKT
>A0A7C4PXQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MLMQVLRDSYTECIERLKSQKYHLIGAHSAVKKCLWVHNALVYGRFCYKCRFYGIASHRC
IQMSPSVLWCWNNCLHCWRVRPQDLGLSSEELTTLPHVDDPEFIAEMAILEHRRIVSGYR
KRTSEEMFKEALNPKHVAISLTGEPTLYPRLSELIEEFHRRGLTTFLVSRGVRPDVLASL
DEEPSQLYISIEAYDRETYNYFNRPLIPNAWELTLKTLEILPSFTSPTVIRITLVKGFNM
SYEVIKKFKKLLELAQPTYIETKAYMHVGGSVGRLGRENMPTFNEVVEFAKRLSDEVGYR
VVSYSRASRVVLLTRLTKPIRLGGGCPKGWEEVDTCEEEIGEYSRVEEAV
>E7QNX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haladaptatus paucihalophilus DX253|TrEMBL
MSESDTVEETSASNRDASDSDDGPKQVSSPNYHSENHTAAQTCGWTANALRGEGKCYKNI
FYGIESHRCIQMTPVVKCNERCVFCWRDHRGHSYELGDVEWDDPEAVVDASIRLQRKLLS
GFGGNDEVPREIFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTNPE
MLERCDPTQLYVSVDAADRATFDHVVRAVDDDAWEKLIDTMDVLAEKDDTRTVIRTTLVG
GENVANPDWYAAFYERADPDFVELKAYMHVGHSRGRLDRTSMLDHEEVVEFTERVGEHMP
DHDVLKQVPASRVALLSKTEDTWVPKLKKDSEFWERDSTTWTRLGE
>A0A0B8NA98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nocardia seriolae|TrEMBL
MTTLSFRRTADAVPATRAGASARAGEREGWEPIRYLAPNWFAVVMGTGIIANAAATLPLQ
FVGLRAAATVVWGLASVILIVLAGAWVLHWRRYPDEARGHGMHPIMMQFYGAVPMALMTV
GAGTLMLGKDVIGLTAALTVDWVLWSAGTVFGLMTAASIPYRMITRHSFDPDSAFGGWLM
PVVPPMVSAALGALLVPYAPEGQARLTMFVLCLAMFGLSLIAALVTITLIWSRLLHHGLP
PVGMVATVWLVLGPLGQGVTASGALANVAPTVFDQDQATGLQVFSMLFGIPAWGFAMLWL
VLAIAVTWHARKSMPFNLTWWGFTFPLGCCVTGSTALYQHTGANLFAVTAVTLYALLVAA
WAVVAAKTVRGIMVGTLLRPAR
>A0A8H4HHL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus fumigatiaffinis|TrEMBL
MAEHSMADGLTKRDPPINIMLTDSSFIGLLAFWHSYRLLFLVAFSTVFVGSRFYHKLQSR
TKTTASSSVPPSPRSQSPEKTEKGVSLESSNKATTQKAERQPAVANGSAKTTSGPKRVTG
KKPSKVAGRRGLTEDAEPLAFIQPIIFYASLTGNTERYAKILLEELRAAAQKRADLQDRE
RGLLPPQIHDLSYIDLDDYFTSAPKPPSNSPGTRYVYCLLIPTYNIDSILNTFLDHLNET
HNDFRIDTGPLSSLAGYSVFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGF
GDVKSDAESSLKEWSQGLQDILSDILKNGGLGEGVPGSGDPVESDEELDDEDTDKDNTQN
VVDLEDIKFGGGQNTAGSPIPVDFTTAGKSSSGQSIEKEMVPKTSPTYAALTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWKVDSPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLDMLHAEHISSFLVCNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFW
ERFQRCLDILREKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGT
STTAGVGLTMQNVPFYEEVAQFVTALNAELQRRGLEYGIAAEHAHSCCVLIASERFHVNG
KWHTRIDYDRFFELLEKEKANGTSFTPEDYMRETEDWALWGNGGFDPSDQRVYTKGKKKH
MQITAEP
>A0A7C4GCD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPSRIIEAYRKQRYHFIGQLAVLKPCHWTRKSILTGGKEVCYKQRFYGIQSHRCIQMSPT
IACNLRCIFCWRVQPEDLGLGWSEVNVLIHDDPEDIVENAIFEQRRVLSGFKGNPKANVK
MVEEAFNPRHAAISLVGEPTLYPMLRELIEAFRRRGFTTFIVSNGTNPKALLNLSSEPTQ
LYITLAAPSREVYLKTMRPLIPDAWERLNETLEILHSFKCPSVLRLTLARNVNMLNPDGY
AKLILKAEPTYIEPKAAMSIGYFTKRLTVDAMPKHDEIKMFAMELSNLTGYKLIDESPPS
RVVLLSKLNKPIKLV
>V4ZQR4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii (strain ATCC 50861 / VEG)|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRKIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFAASQGISS
IQRSTAASHLIPPRSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKTKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIDDERATGEGSDIDTKGGDRELQSAVFPEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGREARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSANVSKECHTGAKPQGSSAAASAVGENSINEVERMCCRPATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKKRGKTKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A3M7IAB9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRARKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKATANQDAQVIENVQPI
IFYYTLGGSTKVYAESVAQDLAASSPSSILEPQLHDLADTEYDDFFLSIPKAEKTAPFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKNEADGMLKEWTEGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETPALRKTKRKPAKRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINDLLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALAKRG
LDYGIGAEHAHSCCILLADRSRFFRVPAAEKDNPAAEKKWHTLIDYPRFFDCLESGKPFA
PEDYVGAPTPEWALWGNGGFDPRDERVDRKGRPKEPKESKVEEVQEVQEVQE
>A0A6A4DX20|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora fragariae|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLSSHPHTLPRNAAAIDSPKRKAKKSPRKVQDKPKDKPS
EPKPMTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEDIV
VAVLSTWTHGKPPEDALVFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAA
KNLDRELSELGSPSLVQLGLGDDNIDQFKQFDVWMDNLVAAMCEYSSEKAVAALKKSDSP
VKAGKKEWLSQNEFRRQKRAKKAEVAAANGETVELNEEDLVNEQFLVDEFSDDEEQNQEK
ADDDSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKH
QLRGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLV
KGSIERHQGMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHI
SSFLVTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHK
GQRTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEE
VRGFCSALCDRVSGEYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELVTKFYED
GTPFTADDYTAPTPHWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A8F5C2Z7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharolobus shibatae|TrEMBL
MQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIESHRC
VQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSGYLG
RNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRSMTTFLVTSGVRPDILAS
LEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIKGYN
MSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQYTGY
KILSEHVPSRIVLLSKLDKPIKIGNAWNDKWDWSTIDMEDDMSGEYKEAEQGCTEGST
>A0A7C1T5V3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum pendens|TrEMBL
MTSVAAALDVQRYLRAGYKLVGNHSAVAICRWARSALRGERLCYKSWYGIKSHRCLQMTP
VLNFCDFACKFCWRMHLPGRYQVPRGWRWDDPREVLDKSIVAQRLLLIGFKGNPLVARER
FLEAMFPRHLTISLDGEPLLYPGLAELIREAKERGFTVFLVTNGSIPARLRELLRRDAQP
TNLYLSVYGPNREVFERTADPRIPRAWEMVNRSLELLREFYESRTVMRLTLVRGLNMVEP
EGYAELVEKGEPMFVELKGYTWVGESQKRLPITAMPEMKELVDFASKLSELTGYQIKLTD
DKSRVVMLVRDEESWERNLKMVEEWRRRERELDERVLSKVEDFTMEEHGYKILKY
>A0A348B379|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfodiicoccus acidiphilus|TrEMBL
MSQEQRIQIDTFTLLNKELEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMTTSSLWCWFRCVHCWRLEPEDVGIEWDETKMPMMDDPDFIAEKSIEEHRRSLSGY
FGREGIDRKMLNDATKPKHVAISLTGEPTLYDRIGELIREYHKRGMTTFLVTSGVRPDVL
ASLDEEPTQLFVSLQAPNERKHKLINRSIVANSWNLFMKTLSILPSFSSPTVLRLTLMKG
MNMGEEDVKDFAKLVEIAQPTYIEAKAYMHVGPSTLRLTRDAMPRHDEVRQFSRKLAELT
GYRVLSEHPPSRIVLLSRLERPFKIGEAWTPEWNWKTPENNDDMNGEYKSAESGCTEAE
>A0A8B9K2V4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
DIWYVEFHMYYTLFNLTLRYLQGATIFQLWISCHAVRKSYFLFLSLQCTSKMICVFLVAT
YTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSEYVGHYNTVGKNVDKW
LWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRLQALARGEKKACSGKCKKS
SCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESVFSLLTHHIYLFYLTGYKLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINAFL
RLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGEWWTWIDYERFQEL
IQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNKTKDISGC
>A0A1I6KF62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicrobium zhouii|TrEMBL
MSDSEGGPKQVSDPDYHSENHTAAQTCGWTANALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASLELQKKLLSGFGGNEKVPRERFEEA
MEPRHVAISLDGEPSLYPYLPELIEEFHDRDITTFLVSNGTRPEVLERCDPTQLYVSVDA
PDRKTFEDTVKAVEGGAWESLIDTLDVLAEKEDTRTVIRTTLVKGHNMHYPAWYAAMCDR
ADADFVELKAYMHVGHSRGRLDRESMPSHDEVLEFTKDVGEFLPDHDTIKEVEASNVAVL
ARDEQTWVPKLEKSSEFWERDPVVSY
>W7I007|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Drechslerella stenobrocha 248|TrEMBL
MELPWSNGQPLGTNLLALWHTVRVPLLVSLALTYLAVVITSRLRARASKSDSPPSPSILE
PQLSAEPDGTVPLPEKFEADVLSKKRRKLSPASNRRPKRIAGTQVQKKKAISPVSDGLDP
ASGPAGAVPAQSSIQVFVFYSSLTGSTAQYAEKLAKDLFSEPPYVPTPAPPVTDIPDDSP
APAKAAFLPPIVENLDYLDLDDYFITPATLQTPNTTSVYLLVIPTYEITSPVDAFLEHLS
ETHHDFRIDTKPLRSLAGFSVFGLGDKEGWPAEEGRGGGVFCGQAKEVDRWMAKLTGGKR
IFPIGMGDVKNDAMGSLREWREHLEILLRDLASGEVIAESNTLDSEDEEDIDQEDTTNNG
MEPLVDVEDIGNSMRQTLTTSQPPKNTKSASGPIAIDFTTTSSSKRTPKVKEMVPKDSPT
YNSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKC
VFCWRHGTNPVSTTWNWTVDPPDMILQGAMDGHYQKIKMMKGVPGVRADRFAEAFRIRHC
ALSLVGEPIFYPHINEFLDMLHSRRISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKES
LRRIDRPLHRDFWERFMKCLEILRAKRHRMRTVYRLTLVKGFNIEEEAEGYADLVEKGLP
AFVEIKGVTYCGTSTSVGAGLSMSNVPFYEEVCEFVRKLNDALGRRGLKYGIAAEHAHSC
CVLIASNDYFIDGRWHTVIHYERFFELLETGKEFGPLDYVGPPTEEWAVWGQGGFNPADE
RVYRKGKNKGKTMQEVAGGEAESGCG
>A0A822IEK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MNSIPETTQSLLKKHGYHLAGTHSAVKTCLWLNKSIRNTGACYKSKFYGMTSHRCIQMTP
TLVCNHRCLHCWRAVEVPVQVPHVWDTPEEIVKAVFNEHKRLISGYGGSEFMDKTRWKEA
FSPKHVAISLSGEPTMYPHLPELIEEFHKNDMTTFVVTNGTIPDMVEKIKPTQLYISLNA
PDENTYEKACSPIGNSWENIKQSLEILKRSGTRTAIRITLTKGVNMVDPEGYARLIELAR
PDYVELKAYMHLGFSRKRLSQDNMPSHEEVLGFSRQVAEVLEYSIADDSGGSRVVLLSKD
GGKHNI
>A0A662QF84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MAIAHGDTRLKLDEVNRLRRAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGVKSHRC
LQITPSLQYCNMMCVFCWRHHTMNRIKPYGGEWDPPEEILDGLIKEQRQLLSGFKGNPKV
DLRLYDEAMEPSNAAISLDGEPTLYPFLGELITLLHERNMTTFLVTNGTMPERLKILLDM
GAEPTNLYISLYGPDRRTHVMTCRPLINDSWERLIDSLRVMRTFTRSRKVIRLTLVKGYT
MRDPERYAELIRIADPDFIECKGYMHVGESQKRLPRSAMPSVMEVEDFAKRLQIHLKGYE
YIAKDVPSRVCLLAKKSSPHYDDVVKNAEKMNELIQNIS
>A0A533UV45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEYISHTGTQNLIQISPLTKAKLKKAKYGVYNHSAVELCHWTKKSFSNEGTCYKHK
FYGISTHRCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPENLVDEPDMIINNLLEERKKL
IVGHYGNTKTDKKKLDESLFPEHYAISLSGEPTMYPKLPNLIRYLKTLKNTKSIFLVTNG
QEPEMLQRLIDEDSLPTQLYLSTNASNKKMFTLVNRPRYKDAWDRWNKSLELLSKMDTRT
VLRMTMIRNFNNTTNYIHEFADLMRRGDPNFIEIKSYMHIGMSTQRLENSDMLEMDEIRS
YSHFLSKSLGTFTIMDESEISRIVVLQNLKRYTERWIEAYEKPIIQ
>A0A2K0W0C1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella nygamai|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKQV
YEEPAKPKAVIEKQTPTIEPVEEKKNVKSQGPRRIKGGIARKPPKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A2E4JSZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEMEPPSNIIQIQPSIINRLKKAKYGVSNHSTVELCHWTKKSFVNEGECYKKKFYG
IDTHRCMEFSPAGMLCQNRCVYCWRPMEFYDSMKMPVEMVDEPESIMKNLMEERYRLMNG
YFGNAKADKKKVKEAMIPSHYAISLSGEPTMYPKLPGLITYLKNLRDTKSIFLVTNGQEP
EMLNRLQDEDALPTQLYLSTNAPNRRIFFMINKPRYRDAWERWWKSLLFLREINTRTVVR
ITLIRSLNADLDLVPLFADIMKRGNPHFIEVKSYMHVGYSNQRLEKSDMMEMSEVREYAN
SLANAVGCYKFMDESIISRVVVLQNTERYLDRLIT
>A0A8G1VPT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus piperis CBS 112811|TrEMBL
MEASANEGFLAFWHSYRLPLLLALATLVVLVRAYHKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKRSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDHEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPENRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAVEA
>A0A364N276|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stemphylium lycopersici|TrEMBL
MALLDLLGQLPAELVLLWHDHRLPLLLAALVVATVARLAVYSRDRREKLSASPAPLSPVE
KQTVELKPEWLPEYTTTISPPGLNVDNHAEDDTGAVAVVAKAKKGPKTVKGKKTPKKNGA
PAPTFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTNCDQASSFLEPQTHDISYI
EHDDFFVSPPKTDASVKYFYMILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREIDKWMARLTGRKRAYPLGMGNVKSDAEKRLQEWRVG
LQEALVEIAEGRGLGEGVPGSGDPAESDEDDVDDAEEGNGQSARVDDVEDLGSMVNSTSA
PIPVDFTTYKKSASKPKPAPAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDVIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLEIMHKNRIST
FLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELSRRGMNYGIGAEHAHSCCILLADRTRFKKNNRWATRIDFERFFDL
YEGKVEGTRVEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKTEEVEE
KGTSGEEHKKQEKMAALEF
>A0A6P6R0Q5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Carassius auratus|TrEMBL
MLFLALVSCLLYCTVGAEKSDALHDVWDFTESCLLTVWQNRLCVYTTAAVLIGVWFTVNM
LLKKKKMVDPISPRLDKSVKNQKLSPETEKVIHVSGVKVFYGSQTGTAKGFAEELAGDVS
AQGIQCEVIDMKDYDPEDRLAEECTSKMLCVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKSSSCKNKKKHKEEAEDGQSHAEKNSS
EEELMESSSDAESSAEEEKAHGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRG
VPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYE
IACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQERVQEYEESGGTKSFSAMDYMAKTPS
WAIFGARERGFDPSDTRFQRKNKTKDISGCLEGS
>A0A0F2L4P3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulcanisaeta sp. AZ3|TrEMBL
MESINEVAKTSLKYHNIEEVNGKVRLRIIEEAKAKLMKASYGIYNHATVELCHWTRSALT
QNQSCYKFRFYGAPAGGSHRCVEFSPVGMICSNRCVYCWRLTDSFDSIIPTEDMVDDPED
IVRGVLLERYRLLTGYFGHSKGKDRAKEALTPTHWSISLSGEPTLYPKLPQLVKYLKSLP
TTKSVFIVTNGQHPEMLEKLEREDALPTQLYLSCNASNRDLFYRINVPVMHREDAWERWL
RSLELLSKLNTRTVIRITLIRSLNYDTKYIPEFAKLMIIGNPHFIEVKSYMHLGHSTYRL
KRNDMLRHEEVKEWALKLLEEINRQGGNFKYMDEDPPSRIVVLQNMNRYINRWIVKPEEQ
PNTLSEADKKKLEMAVKNELEQV
>A0A811TC47|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Argoarchaeum ethanivorans|TrEMBL
MTTFVVTNGTYPAMVERINPTQLYLSLNAPDEDTYRQTCNPQEAGLWERICKSLDILREK
ETRTVLRITLTEGLNITNPEGYAALIDRASPDYIEIKAYMHLGFSQKRLERSAMPTHQRI
REFSERIMQYTDYKQADESQISRIVLLSKNGDVKKIV
>A0A0P1A593|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmopara halstedii|TrEMBL
MAVGVLLHIQKIRRSIATCDDAAVSTKCKPKKSQQQCDKGSSEPMTVRILYGTQTGTSKA
MAEALEKTLFALNISGFHFQTSVVSMKDYDQDNLEQEAIVVAILSTWTHGQPPEDARMLC
NWIKDMTHDFRVSKKWLSGVQHAVFGLGNAEYDENYGTAAKNLDCNLCNLGSPALVTLGL
GDDNLDQFKQFNDWMDNLVAAMCEYSSEKAVNAFRKNQSLSKTEKKDWISQKKFRRQKRA
LKAALTAANDEQSDEEEQRKRRMNDDNGMVDVEDVGASMKESEAANMSREMVTPMQRKAL
TKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHAFYGITSFQCMETTPSLACANKCVFCW
RHHKNPVGRVWRWKTDDAKTLVKARWNDAFTVRHCALSLVGEAIMYPQINEFCKQLHHRR
ISSFLVTNAQFPEKIAALNPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKH
KGQRTVYRLTLVKSYNMEELDNYAELINIGHPDFIEVKAVTYCGKSDGSNLTMQNVPWHE
EVRSFCSALCDRVSGDYALASEHAHSNCVLIAKKKFYREGVWHTWIDYDRFHELIAKYYE
DGTLFTADEYIAPTPHWALYDSKEQGFDPAETRFRRSKDGKVVKFAYLSTESGCG
>A0A7U2QUL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus flavus|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAIILRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSTAPNQSTVKEMVPKTSPTYAALTKQGYTIIGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>M0B4J3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba aegyptia DSM 13077|TrEMBL
MSDSADAGVEVGADADPDQGRDRDRDDGDPAGGPAQVSSPNYHSENHTAAQTCGWTANAL
RGDGRCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDA
SIELQKKLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITT
FLVSNGTRPEVLRECDPTQLYVSVDAPERHTFDQVVKAVDDDAWDRLLETMAVLREKDET
RTVLRTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVLE
FADAVKSHLPEFSECKGVPSSRVALLSKTSDTWVPKLKKGSEFWARDPVTGTGD
>A9UQE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosiga brevicollis|TrEMBL
MREAQTEEKRQRKAAEVVADRAAATAAITTTTTTTAAAPAEQPKAKAATVTPAPARVAPS
SKSVQPLYKTVSKPLAADAPQVVTIYYGSKTGTAEGFANRLSNALSQATTAPVTVASLAE
YDIDKLSAEKGIVIFITATYEHGSPPDNANWFHTTLLDAANDFRVKKTQLANVRYAVFGL
GNSLYRDNFNRVAREIDVSIAALSGLRIVPTALGDENVANSKTGSLEGDFEAWLQEAVAR
IPAALQGSAVEAYETDGEADSEEEDEADDGMVDLEDLGNALVKGRAQRQAQDQDARVGKP
RAMITPALRKALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIASHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWQMDEPIEIVNGAMQNHYDMVRQFSGAPGVMPERMR
EAMEIRHCALSLVGEPIMYPKINEFLDLLHDRNISSFLVTNAQFPDAIANLRPCCQLYVS
IDASNEQSLKQIDRPLFKDYWPRFLECLRELGRKGQRTVYRLTVVKAWNDDEIRGYADLV
QLGEPDFIEVKGVTFCGTSKASSLTMDNVPFHEEVVGFVQTLVDMLPDYELVCEHEHSNS
VLAVHKRLFVGGRWHTWIDYPRFIDLVRSGKPFSTVDYMAPTPEWAILGHGARGFDPVEV
RHRRNKPTGSGC
>A0A0C2J7M4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sporothrix brasiliensis 5110|TrEMBL
MASTSWASSPFIRDLLIVVVDAWHTYRIPILLATFATLVSLRIYLHVAGSGDDREGLLVF
PKIYDGTTVVDENKKLQQQEQPPSVQEDVKIAVLQQTKTISYPGSTSDKKTITPTATKKS
STAKTANATTPSSTTTKAAAGPRRIKGELPKGSGAAAVARVPTRIQTIVFYSSITGATAK
IVRDYAAELSTTLGELKPDGGSDSKGNVFAPVEVLDIAEVDLDEYFISPPKDASDAASGR
TTDYLYLFLLPSYNIDSINDTFLEHLKETHHDFRIDTAPLAPLLGYSVFGFGDREGWPTE
DEGFCFQAKEVDKWMAKLTGRKRAFPMGVGNTKTDAMLRLAEWSEGVVDVLGLVARTGSL
GTGVRGSGDAVETDDEDEDEASDDDSDAYDDGSNDDDGAADANGAAYDNDDVLFGGNAAR
NANVKRLKKAGVIDDVEDLGRLLRSSKEDDAAVEDTAVDDVAEAPGTNVNKAPIAVDFTT
YGANDSSTTNGSPRRTGRRAAAPAPKEMVAKDTPTYKSLTKQGYAIVGSHSGVKICRWTK
SALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLI
FDGVKANHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHGEN
ISSFLVCNAQHPDQLAALHHVTQLYVSIDASNRETLRKIDRPLHRDFWERFQRCLAILRE
VRFRQRTVFRLTLVKGFNIDDEVQGYADLVEQALPCFVEVKGVTFCGTSTSAGVGLTMAN
VPFYDEVCEFVTALEKELQSRGLAYGLAAEHAHSCCVLLASERFKRDGKWHTVIDYDKFF
ALLREKGPQGDFTPEDYMGPPTAEWATWGRGGFDPRDQRVDRKGRPIER
>A0A0H1R711|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sediminis|TrEMBL
MHSEACKALRKQGYQFITPNSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LKCNQQCLFCWRSFEHEVVEEEECPPDVIVANLRRVQKKALSGYKVSPNVAPEQFAEALD
PTMVAISLSGEPTCYSRLAELVDALNADGYTTFLVSNGTRPDVLARCRPYQTYVSLDAPD
RETYLSLCRPREDYWDCIQESLAGLRERRSAVRTTVVRGYNDFSPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRTQMPEHREVRAFSELIAKHCDYSIRDESPVSRVVCLERDV
>A0A2U1NCK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Artemisia annua|TrEMBL
MPTTTVTTHLTLLTILSAATLYCLYKSHSLRKPKHPKIKKPLNPNPNTPLNPKPTKTPKI
FYISETNTSKNLAKHLYKILKTNNLKFDLINPETYEPEDLHSEDLVLIIASTWQDGLSPS
NGVFLSNWLNESVSDFRVGSLLLKGVKFGVFGVGSRSYGEERFNKVGRGFSSGMKALGAV
EILPICEGDVDEGDLDEVFEKWCEDVVRVLKSGVLENGENEEVGYEEEGSEYEDYESEEE
EVEEEGIVDLEDIAGKAPTKKDLEKGAGMRNGKKNGVKEMVTPVIRASLTKQGYKIIGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
QWQMDDPLMIVNSALDQHKKMIKQMKGVPGVTAERLSEGLSPRHCALSLVGEPIMYPEIN
TLVDELHQRRISTFLVTNAQFPEKIISLKPITQLYVSVDAANKDSMKAIDRPLFGDFWER
FVDSLKALKDKQQRTVYRLTLVKGWNTEEVDAYSRLFSIGNPDFVEIKGVTYCGT
>A0A0B1P902|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Uncinula necator|TrEMBL
MFVLTGLGNLCWSAMIENSLLLWHYYRFSIILTAATVILFLRVILHLRTAKKTYPDHKSI
DVVHLPALISEGKGNFVDETASKPGKSPRRIIGGLKESLTAQKINIGCQKIQCFVFFSSL
TGTTKNTAKIFVDSLARSLLKIKTFQTRIFLDSEVLDLSEIDFYDFFLKSPNDNDAEIRN
FYLFLLPSYNIDTILDNFIEHLKETHNDFRINLAPLSSILGYSVFGFGDREGWPTENMGF
CSQARHVDKWMARLTGGKRAFPLGMGDIKTDGQENLEKWTEGVLDVLKQVASTGYLGEGI
AGSGDADESDLEETDTEQNLIEKPRPRKITPERQLKKYAQNDLEDIGLTLNVDATNNALQ
EIDFTTYSAKLSPTIKEMVPKDSPTHTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCY
KYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWRVDPPELIYSGVKASHYQ
KIKMMRGVPGVRAERFTEAMNIRHCALSLVGEPIFYPHINEFTALLHADHISTFLVCNAQ
HPDQLASLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRHRRFEQRTVFR
LTLTKGFNMEDEIVGYADLIEKSLPCFVEIKGVTYCGSNTSKAGVGLTMQNVPFYDEVCT
FVQELDRELSRRELGYGIAAEHAHSCCVLIASKRFQRHGKWYTRINYDEFFRCLESGKKF
GPEDYIGLETPEWATWGKGGFDPRDERVYRKGKNKVPLSLAVK
>E3GWM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermus fervidus (strain ATCC 43054 / DSM 2088 / JCM 10308 / V24 S)|TrEMBL
MIRVEKKEIERLKKMGYHFVGKNQHTAVKTCLWTKKSLLDEGVCYKEKFYGIRSHRCLQM
SPSVFFCQHRCLFCWRDLISKSYKWEGPYDDPKEIVDGCIEAQRALLCGFFGNEKANKKK
VLEAQNPNNAAISLVGEPTLYPLIDELIEEFHRKNFTTFLVTNGLLPERLENLNEEPTQL
YISLEAPNKDKYIKICRPLVKDGWEKLNKSLEIMPTFNCRKVIRITAIKGINMDYPDKFA
ELIKIAEPDFVEVKAYMYLGYSRKRLKMENMPLAQEVFDFANEISKEVGMEIVDKSERSR
VALLG
>A0A897N0M2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halapricum desulfuricans|TrEMBL
MSDEGGPRQVGDPDYHSVNHTAVQTCGWTDNALQGEGKCYKYAFYGIESHRCMQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADATIDLQRKLLSGYGGNDDVPRERFEQAM
EPRHVAISLDGEPTLYPHLPELIEEFHDREITTFLVSNGTKPEMIERCEPTQLYISVDAP
DRKTFEETVKPVGEELWERLIETLDVLAAKDDTRTVLRTTLVGGENDYRPAWYAAMADRA
DVDFFELKAYMHVGHSRGRLDRSSMLDHDDVVSFAREVQSFLPDHDHLVDVPDSRVAMLA
RDSDTWVPKLQKGSEFWADDPAAR
>A0A497TET4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIPEPLRKSLVNQHYKIIGNHSAVKLCGWLKRSLKDQGYCYKQKFYGIQSHRCLQMTPWL
ACSNRCVYCWRVIEKLNIKPEEIDEPETIIEGSVQAQRELISGFKGYEGTNLKKWKEANS
PNQAAVSLAGEPTMYPKISDLIKEFHRRGFTTFLVTNGLFPERLENLEAPTNLYISLDAP
DPETYERIDRPKLKDYWERLLRSLEIMNSFRTRRVIRLTMVKEWNMHSPEKYAKLIEKAN
PDFIEVKGYMWVGESRKRLPSETMPSHKEIQEFADKLSKETGYVQKDEQEESRVVLLSKV
>A0A8H4D6F7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] haemuloni var. vulneris|TrEMBL
MASGTPILALCSLIYWLSGGRTTVLAAAWFAVFVHKQKKHDSKSSPITEPVKSSRIMEVD
FTNAFTPETKTTFPKTVPLKKKTRKTRTAKVFKAKPGKSVGGGGGAVSHLTASSVHLEKC
PVYIFYTTLTGSSLRVAKALHEKIAGIDGVEVPPRLLSLDDDVDDLEEYFLRTPKSENPP
VYLLVLPSYETDSPIDYFLEHLTETYQDFRVDKYPLRTLAGFAVLGLGDSESWGGSQFCY
QAKSADKWLGKLGARRLFPVGEVCMKHEGEPKTQDWINGFSELLVDEQPFLLEDDPAAFD
SDAEEAEAEAEDEKDVVDVEDMGAIIRASKNKDSAVMEPKQMVAEDSPTYKSLTKQGYTI
VGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPV
AKSNWRWEVDPPEKVLFGALEGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGEPIF
YPHINEFVGMLHERHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKTDLKKVDRPLNS
DFWERLMSCLDIVRTIQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGATFC
GSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLDYELAAEHSHSCCILIAHTKFKI
NNVWHTHIDYPKFFELLESGQEFCDLDYICETPEWAVWGAEEGGFNPKDTRYDRKAEKLK
KKQARDDAAAKALQVQKAESIKATTNEFSEHTRELFVS
>A0A1E4SR10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Suhomyces tanzawaensis NRRL Y-17324|TrEMBL
MAFGIPLLVLCSAINVFSGGKLGYYLIILAAFLAIKSQEASKTKNSRLDAPQSSVNSKDV
LNSKESPIYAVDFTSTTFTPTESTTIPKAVPLRSRAKRSPKVIKAAKPIPNNLAEASLTK
SSVNLLQSQVYIFYTTLTGSSQRVAQALHTKLTNLDGLANPPKMLSLDDDVDDLEEFFLK
TPKNGDTKSIYLLVLPSYETDSPIDYFLEHLSETYNDFRVDKYPLRSLLGFAVLGLGDSE
SWNGEKFCYQAKLADRWLGKLGGRRLFPLGEVCMKFEGEPKAQDWIQSFATLLADDEPFY
LDNDDDIDDSDREDEEVDDADTLVDVEDMGNIIRKSGTTSIGMSEAKKMVAKDSPTYKSL
TKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCW
RHGTNPVAKLNWRWELDPPEKVFEGALAGHYQKIKQMRGVPGIQNDRFQEAFQVKHCALS
LVGEPIFYPHINEFVDLLHKQHISSFLVCNAQHPDNLAKLAKVTQLYVSIDAPTRTDLKK
VDRPLNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMNDIASYADMVIQAQPSQIE
VKGATFCGSSNGNGNPLTMQNIPFYEECKLFVVSLVEELNSRGHSYEVAAEHAHSCCILI
AHTKFKINGKWHTHIDYPKFFQLLESGEEFNDLDYVKETPEWAVWGSEEAGFNPDDTRYD
RKAEKLRKKLEREDLSRKIQASK
>A0A3N5RE89|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSDEYISHTDTSSLIQISPSTKAKLKKAKYGVYNHSAVELCHWTKKSFSNEGTCYKHK
FYGISTHRCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPANLVDEPDMIINNLIEERRRL
IVGHYGNTKTDKTKLDESLLPQHYAISLSGEPTMYPKLPDLIKYLYTLKNTKSVFLVTNG
QEPEMLQRLIDEDALPTQLYLSTNASNKKMFSIINRPRYRDAWERWQKSLELLSEMNTRT
VLRMTVIRNFNESTSYVNEFAELMKKGNPHFIEIKSYMHIGMSTQRLERSDMLEMDEIRN
YSNLLCKSMARFSIMDESEISRIVVLQNLERFTERWIEGYEKPLIQ
>A0A835X9C6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGEVVQEEELIQIKPGVLQQLKKAKYGVADHSTVQLCHWTKKSFKNEGDCYKHKFYG
ISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEIVAEPEEILTKLMEERRKLIMG
HYGDIRSDKQKLDESLRPSHYSISLSGEPTMYPKLPELIKYLKSLKATKSIFLVTNGQEP
DMIKRLSDEDALPTQLYLSTNAADYESFLKINRPRYKDSWERWNTTLEMLKELDTRTVLR
ITLIRNYNTSDEMIPALASMIKRSSPHFIEVKSYMHIGRSTNRLERTHMLEFDEVKRFAS
ELASQSKIFSVMDESDISRIVVLQNQERFIDRWIPAYLETN
>A0A836BNG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGEIVQEEDELIQIKPRVLQQLKKAKYGVADHSTVQLCHWTKKSFKNDGDCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEKVAEPEQVVKKLMEERRKLIM
GHYGDSRSDKNKLDESLLPSHYSISLSGEPTMYPKLPELIKYLKSLKETKSIFLVTNGQE
PDMIKRLADEDALPTQLYLSTNAADYESFMKINRPRYEDSWERWNSSLEMLKELDTRTVL
RITLIRDYNTTDEMIPAFASMIRNASPHFIEIKSYMHIGRSTNRLERENMLELDEVMHFS
SELVRQSKIFSVMDESHISRIVVLQNQERFTDRWISSYLDTN
>A0A832YVE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus profundus|TrEMBL
MITKKLLKDLKGYQIVGRHSAVKTCFWLKKSLKNEGVCYKQKFYGIQSHRCLQMTPALIC
NQHCIHCWRPLELLTNIEGWDDPEFIVEESIKAQRKLLSGFWGNEDVDKKKLEEAYNPNQ
VAISLIGEPTLYPYLPELIEEFKRRGFTTFVVSNGTRPEMIESIEPTQLYISLTAYNEES
HLRLNRPVRSFWDNIMKSLEIMSQKTCRTVIRLTLVKGYNMEAVKFAPLIEKASPMFVET
KAYMYLGYSRLRLPREAMPEHEEVRRFAEELAKITGYEIADESVVSRVVLLKAT
>Q7RC01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium yoelii yoelii|TrEMBL
MFKYFRSKLLKKNKDGNSEKNWKNESAKLKNESAKLKNEAKDNFDNLKKYEKNIIKCGNT
HFNNYLNCSIKNNVSEINFSLVNGNEFDSYTFFENSENNDLNFLFMFISTYNFGAFPANC
YKLEDVLTDLINDFRIEKNYLKNIFYSCVGFGNKEYGNTYFCTPIKKCDKFLSSLGANKL
EKTIKLCSTMDNEEEIIQWKSNLLTKICLSLFLYNFNYTKFSNNFFHYSNRKNYNTLKYY
CTYFCKKNEDVKNRIINDKQNEQTTNLLNNNNIKKGDSINNDQNKLINNINGHISLFTSN
IDGNSDEKCGCTSNNCLNGNDKYINKKKIINNNFETPIVNECCKKEYDKNDELINSDFNS
ESMSENNDEINCNSSEELEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKS
QLRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIV
SEAVKKHKNMIKELKGVQNVINERFENAKNIKHCALSLVGEPIMYPDINNLIDELHKKNI
STFLVTNAQFPNELKKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKVLKEK
KERTVFRFTLVKEYNMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWH
EEVYQFAFHLINSKRSISDIYEISCEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVK
QNANFTAIDYCEETPEWAVIGAPECGFNPSDQRVYTKGKNKNKNNINTMEIKT
>A0A832S6P4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MGLQRRGRLLRADVVSTILERLRKAGYHIVGSHSAVKKCHWTHVALTERRFCYKCKFYGI
ASHRCLQMTPAVIWCWLRCLHCWRAEPGDLGLQWDDTKLPTVDDPAFIAEKSIEEQRKII
SGYKGHPKVDPKMFEEAMNPKHVAISLSGEPTLYPRLSELIEEYYKRGMTTFLVTHGVRP
DALAELDPEPTQLYLSLEAWDEKSFKEFNRPVLPGLWSAVLQSLDILPSFSSPTVIRITL
VKGFNDHERALEGLAKLVERGYPTYVEVKAYMNVGYSRYRLTKENMPTHAEVRSFAERLA
EKIGYDVVDEQRSSRVVLLSRIGKPIRVGEGCPGGKAGELPEGTEYELSERVK
>A0A8H6UZM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus felis|TrEMBL
MAEHSITEGLLAFWHSYRLLFLVALSTAFVGQRFYRKLQSRTKTTASSSVPPSPRSQSPE
QTEKGTSLESSNQATTEKAEQQLPLAKAPPKGTSGPKRVTGKKPSKVAGRRGQTQDAEPL
SFIQPIIFFASLTGNTERYAKILLEELRAAAQKRADLQDRERGLLPPQMHDLSYIELDDY
FISAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGALSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGFGDVKSDAEASLKEWSQGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDVNKSNAQNVMDLEDIKFGGDKNTAGSP
IPVDFTTAGKSSSGQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGEHISSFLVC
NAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGTTTSAGAGLTMQNVPFYEEV
AQFVTALDAELQRRGLKYGIAAEHAHSCCVLIASERFHINGKWHTRIDYDRFFELLEKEK
ADGTSFGPEDYTRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A1B6MTM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Graphocephala atropunctata|TrEMBL
KLQEKLKSSVEVSVLDIANIDPEETLLELASARTVVALLLPTHSDGSPPPSAAWFYKWLG
ESASDFRYDKASFKNLHYAVFGLGNSVYQEHYNVVSKQVDQWLQELGAQRALPLAFGDQD
SLEEDFHQWADLVMGLTAAESLSASLATGEGEGEELLANGLLDLEELGPALRQMKRQNNT
APVVREMITPTLRQALTKQGYKLLGTHSGVKMCRWTKAMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGTEWRWKTDDAQDILSDALAAHYNMIKEFKGVPGVLP
ERLAEGLQVRHCALSLVGEPIMYPHIGSFVRLLHRQRISSFLVTNAQFPTAIRELSPVTQ
LYVSVDASTKSSLKKIDRPLFSDFWERFLDSLRALSEKGQRTVYRLTLVKAWNVEELESY
SQLVLLGKPDFIEIKGVTFCGGGDGNSLKMENVPWHEEVIEFSRKIAALLPDYALASEHE
HSNCVLIAHKKFLVNGEWWTWIDYDRFLELVDRFYETEGRETFSAEDYMMRTPSWAVFGS
EERGFDPVETRWQRRAATAGC
>A0A447CGY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Podospora comata|TrEMBL
MVFPNDWEGFSPAIMGRVMDCAVDLWHEHRIPILLSTAFILTFLRFYLRLNDAQSEQQKL
VALPRALNKDEKKTTTTTTEKLDKVVVKKVSGSEGSSGDDEKKEGVKKKSAGPRRIKGDA
SKRVKKEGGEVRKIQVLVFFSCLTGSTEKIAKQFAGAFEEALTKAKGEQTTFLPPQVLDL
SEVDYDEYFIGPPKTEGEEKLDYFYLILLPSFNIDSINDTFLEHLQETHHDFRIDTSPLA
PILGYSVFGFGDREGWPTEKEGYCFQAKEVDKWMAKLSGRKRAYPLGMGDWKRDGKERLA
EWKSGLVDVLGQIEQNGGLGEGVPGSGDPIESDDEEFDDDGEVYDEGAEQNGKSKSSGDL
GDLEDLGQIMAASGNTGKKSSGPIAVDFTTEGKPKRKAAAPAVIKEMVPKGSPTYNSLTK
QGYAIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRH
GTNPVGTNWRWVVDPPDLIFNGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVG
EPIFYPHINKFLGMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKESLRRIDR
PLHRDFWERFNRCLDILRERRFQQRTVFRLTLVKDFNLEDEVEGYADLVQKGLPCFVEIK
GVTYCGTSTSSSAGLTMQNVPFYNEVCDFVVALEKALKKRGLDYGIAAEHAHSCCILLAS
DRFHKEGKWHTRIDYERFFELLEERGPDGEFTPEEYMGPETPEWATWGRGGFDPRDQRVD
RKGRPVEVS
>A0A6I9SFM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Elaeis guineensis var. tenera|TrEMBL
MMATSHSVSLPSRLALFALLSLSSSFFLWKSRRLRRLRLSSQNPNPDPSPRGKLFFASQT
GTSRALAGRLAERLHAAGFPFDLVDPRGYEPEDLPKETLVLIVASTWEDGKPPPNAEFLA
RWLAESAEDFRVGSLLLSRCRFAVFGVGSRSYGETFNATAKDFSRWMRAVGATEMLPIWE
GDVDNGDVDEVFDSWSQNVIGLLKGDVRENGGHLASTLEINGFDSVEVEEEEEEAMESAV
VDMEDIAGKAPSRKSTGALSNGGQNGDNGLREMVTPIIRTSLEKQGYKIIGSHSGVKLCR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDDP
LVIVNAAIDQHTKMIKQMKGVPGVKQEQLLEGLSPRHCALSLVGEPIMYPEINSLIDELH
SRHISTFLVTNAQFPDRIKMLRSVTQLYVSVDAATKDSLKAIDRPLFSDFWERFVDSLKA
LQDKEQRTVYRLTLVKGWNAEDIDAYANLLGIGKPDLVEIKGVTYCGSSATSKLTMENVP
WHSDVKAFSEALAVKSSGEYEVACEHVHSCCVLLAKASKFKVKGQWFTWIDYERFHELVA
SGKPFKSEDYMALTPSWAVYGAEEGGFDPDQSRCKKERRHGAASIRG
>A0A8C3US87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Catharus ustulatus|TrEMBL
MDTWSYFHTCLVSIWLHRFYIYSAVAFGIILWIVIQLIIKLRRFAKALAEAVTSLNLPVE
TSSRNICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSAYV
DHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQLQALCK
GEKKPCSGKCKKGKCKSLGKGREELRSHELVMEPEELFETSSEEEAGGTDSVIDVEDLGN
IMGHMKKAKREQELQEGAAGAGRKEEAVRREMITPALREALTKQVDAAGPRGLHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIREFKGVSGVKAARL
EEALAVKHCALSLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYV
SVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKSWNVDELKAYADL
ISIGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSN
CLLMAHSKFHVDGEWRTWIDYGRFQELVREHEQSGGSRTFTAAEYTARTPPWALFGARER
GFDPLDVRFQRKNKARDVSGC
>A0A388QKR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosarchaeum sp|TrEMBL
MSCSGETVENEDRLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVAEPKEILTKLMEERKKLIM
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSFLKINKPKYNDSWQRWNKTLEMLKHLDTRTVL
RITLIRNYNDQKEMIPAFASMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVRKFS
EEIAKQSQVFSVMDESLVSRIVILQNDQRVH
>A0A7C4FET1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MALAGGATVNPVVQALSVLKKQRYHIIGSHSAVKKCYWVHKALVERMFCYKAKFYGIESH
RCIQFSPSVLWCWNYCLHCWRYRSRDQWSDIWFHFPENVDDPRFLVEMAVREHRRTVSGY
KKYPDVDKKMYEEALNPKHVAISLTGEPTLYPRLGELIKEFHNKGLTTFLVTRGIKPEVL
ANLDEEPTQLYVSLEAYDLGSYTKFNNPISGNLWKKTLETLEILPSFSAPTVVRITLVKS
FNMNEEAVDTWARLLKVAQPTFIEVKAYMHIGASITRLSRSDMPSHTEVRRIAEELAKRL
GYNIVSESVPSRVTLLSTLDRPVIRYGDPPVAWHDVDVGDEDSGEYGSANEAP
>A0A7K5CDV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Motacilla alba|TrEMBL
MDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTTRTKRKKSHGSPSSPEGTSDK
LENGCALRQTQGVHVSGVKIFYGSQTGTAKRFAKDLAETVTSLNLPVEVINMGDYDPEDG
LVEETSSRKICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGN
SAYVDHYNTVGRRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQ
ALCRGEKKPCRGKCKKGKCKSSGKRSKESSDREQETSEQDNTEAEELLETSSEEEAGGTD
SVIDVEDLGNIMGHMKKAKVLLLEGVWNAAGAERREMITPALREALTKQGYKLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWR
MDQPEEILQEALEKHQNMIRQFKGVSGVKAARLEEGLAVKHCALSLVGEPIMYPHINRLV
RLLHQHGISTFLVTNAQFPEEIRKLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLD
SLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTM
ANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLLAHSKFQVDGVWRTWIDYSRFQEL
VREHERSGGSRTFTAAEYTARTPSWALFGARERGFDPLDVRFQRKNKARDASGC
>L7LW82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhipicephalus pulchellus|TrEMBL
MCTADFPHGARXVMFQSITRRFVTYLLCALLIFHTVHAKGNVNEKSRSDWYPSSYTTTLC
GGVLAVLFFVIAREKLNLSKIKTRDPFKQRQRKRNGKSVKVLYGTQTGNAKILSEKLTAE
LDALDYDVEMVNLKHVEPEECLLGQVKAKGLCIFIVSTYVDGSPPDEATWFYDWLKDTYA
DFRVHKYYLQGLNYAIYGLGDSAYGDNYNKVAKDMDFWLSKLHATPVVPLCLNDESHDEG
KYGTGKFPGWKDDVLAYLEGRPSITTQPREAQIAPEDVAYESSSDEGEPELIDLEDLGNV
RSTAKSKESKTVKNGEARPDMLTPLLRQSLGKQGYHLIGSHSGVKLCRWTKAMLRGRGGC
YKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWKWNMDSPEMIVENALKNHY
KMIKEFKGVPGVLRERLEEGLRARHCALSLVGEPIMYPEIGKLVRLXHYKMIKEFKGVPG
VLRERLEEGLRARHCALSLVGEPIMYPEIGKLVRLLHDQGISTFLVTNAQFPDALRQLGP
VTQLYVSVDASSREALKRIDRPLFPDFWQRFQDSLSTLADKGQRTVYRLTLVKEWNMDEM
QGYANLVALGKPDFIEVKGVTYCGDSKGARLTMSNVPWHDEVLSFVKQLVALLPDYSIAS
EHEHSNCALIAHNKFRVNGQWNTWIDYERFHELVQRFYQTGETFTSLDYAAPLPHWAVFG
AKERGFDPSDTRMFRKSKKDISGC
>A0A843INT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MSFDKNQIAKLEKSGYRFVGAHGHAAVKTCHWTRQSIADKGVCYKEKFYGIKSHRCLQMS
PAVPNCQQECEFCWRDLTYTQTAWEDEEYDDPKTIVDEAIAAQNQLLCGFYGNDKANKKK
LEEMKNPTNAAISLAGEPTLYPKIDELIGEFNRRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPSKKIFEDVCRPRINDAWDNLNESLETLSSFNSRTCIRNTCVRGRNMEDPEGYA
RLIKKANPDYVEVKAYMCVGSSRDRLTLDNMPTFDEVKDFARKIGDACGKEIVNESQISR
VVLLE
>A0A1I1K3E1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobiforma haloterrestris|TrEMBL
MSDSADSPESAGATDPGTDAPAGDDPDADGGTPAQVSSPDYHNENHTAAQTCGWTANAMR
GEGKCYKNIWYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYELDDVEWDDPEAVVDAS
LELQKKLLSGFGGNDEVPRERFEEAMEPRHVAISLDGEPTLYPYLPELIDAFHDRDITTF
LVSNGTNPDVLRECDPTQLYVSVDAPERHTFDEVVKAVEDDAWERLLETMDVLAEKDETR
TVLRTTLIKGENMHHPDWYAGFYGQADPDFVELKAYMHVGHSRGRLDRSSMPDHEEVAEF
ARSVGEYMPGFTEVKEVPPSRVALLSKTSDTWVPKLKKDSEFWERDPVSGTAGD
>A0A0V0W9I2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella sp. T6|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSILSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEDDNFDHIQSDFLNWSLQLIKYLEVREVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKI
CRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTD
PAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELIFK
MHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSI
DILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKVGVTYCGDSKDSKITMA
NVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLA
ERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>B6K6D6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Schizosaccharomyces japonicus (strain yFS275 / FY16936)|TrEMBL
MDVQGFFEQNRWLIYALLLSPVLVHFVLAKKLAKPEKIASATSLKGSTPKAPKVFRKTEK
TKHSNRKIACEASTKSSRKLTDISACSINIFYSTLGGSTQKFAEHVADRIRSSLQTELVE
ILNLDYIDLDEYFSKGNSNTVYLVLLPSYAIESSIDYFLSALQTTIDDFRIVARPLEKLR
GFAVLGFGDFEQYAGDLFCYQAIAADQRLAKLGAQRIAPLGVVNVKLEKAQVYEAMEAWT
DLFLQYAKEKAVVPSSATRFNATTDAFSSKTTLVDVEDMGSLLDRAKQELSLPIGTKLMV
SEQSPTYRSLTKQGYSVVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMEATPSL
ACANKCTFCWRHGTNPVGTEWRWKVDPPEMIINGILQSHYDKLKLMRGVPGTRPERLAEA
SRVRHCALSLVGEPIFYPYINEFVSMLHEREISSFLVTNAQHPEALRRMGQVTQLYVSID
ASTKDTLKAVDRPLFKDFWERFLTCLEILREKHQRTVYRMTLVKGFNMEHVKEYVNLVRL
GLPCFVEIKGVTYCGNSDQSPLTMKNVPFYEEVVAFVKSLCEELRVLSAETGVTYEIAAE
HAHSCSILLAQTKFKINGVWHTHINYDKFFRLVREKKEFGPMDYAAPTPDFAIFGNGGFN
PDDERFYRKGKKNANSSAKGITA
>A0A673K691|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
QYSGSYPFRLVCVLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGVCFTMNMLFKKKKTVD
PVSPWLYKSAKKQELSAETEKVIHVSGVKVFYGSQTGTAKGFAKELAGDVSAQGIQCEVI
DMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLEEASTDFRYGKTYLKG
MRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQA
WKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHSLEELMESSSDAESSSE
EEKFHGSVIDVEDLGNVMNHMKKAKVKTKPDSQRVKLSKQNGVRKSESEEEQREMITPAL
RDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
GFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQFRGVPGVRPERFEEGLTVKHC
ALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKF
KVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRF
QRKNKTKDISGC
>A0A2I0Q297|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriales archaeon HGW-Methanobacteriales-2|TrEMBL
MLLSDPAITSLEKKGYRFVGSKKHAAAKVCHWTKKSIMDDGVCYKEKFYGIESHRCLQMS
PSIPFCHHKCLFCWRDISITSTTWKDEFDDPGEIIDECIKAQRKLLVGYFGNPGANQKKI
SEAQDPTNAAISLAGEPLLYPPINQLLEEYKKRHFTTFLVSNGLSPDKLGKLNPEPTQLY
LSLDAPNPEIYKKICDPQVKDGWDNLNQSLDLLSSFNCRTVIRMTSVAGYNMTHPEEYAR
IIERSNPDFVEIKAYMYVGSSRDRLTFDNMPRSKDLESFAQEIASLCGREIVDKSSESRV
VLLS
>A0A446UNR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRTLRPSPSPSSSPAAAAAPT
LLYASATGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAPP
PGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGAV
EVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDDD
DEEEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLEKQG
YKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEP
IMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPL
FSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTYC
GSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGKW
HTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAALK
G
>A0A8H6D315|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium mundagurra|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLALCVILVAIRTYFHINGQRTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVRSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGNLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDRENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWNKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STAQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A086L141|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii FOU|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKVRGKAKPEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGEYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A832TXG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp|TrEMBL
MPLEEKKEEKENSRESFPEVQEENRDEEQTSLPFDIPDFETLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVSVPVPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFMVTNGTIPSMLEKVNPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDIMK
EKSSRTVIRTTLVKGENMSNPKGYAELIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKEVAKHLGYEVIDDSEISRVVLLSKDGRKSPVKKAFCPG
>A0A8J8C8Q3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicroarcula salinisoli|TrEMBL
MSDSDSGGPKQVDDPDYHSQNHTAAQTCGWTANALRGEGKCYKYAFYGIESHRCIQMTPV
VKCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFEQ
AMEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTHPEMLRRCDPTQLYVSVD
APDRKTFDSTVKAVEDDAWDNLIDTLDVLAEKDDTRTVIRSTLVREENMHRPAWYAAMCD
RADADFVELKAYMHVGHSRGRLDRESMPSHEEILDFTESMQEFLPDHDTIKEVEPSRVAM
LARDDDTWVPKLNKDSEFWADDPLVEY
>A0A832LH23|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp|TrEMBL
MPLEEKKENAREDTPEFQEENRDGESTFLPFDIPDFKTLLKKQGYALAGRHSAVKTCLWL
RHAMNDQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVSVPAPKEWDSPEKIV
EESIACQRKLVTGFGGSPNALKERWLESNEPNNVAISLSGEPTFYPYLPKLIEEYEKRGF
TTFLVTNGTNPDMLAKISPSQLYMSLDAPNLETYLKVCQPRSPALWEKINESLSLMKQKK
SRTVIRTTLVKDENMFNPEAYARLIEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVL
KFSKELAKHLGYEIADESEISRVVLLSKDGKKSPAKRLPYPN
>A0A1A8CM13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius kadleci|TrEMBL
MLRLLLFLSHITAHAASSDTNAQQEAPRPGESYLLWVWTNRLYVYSAAALVFGTWFLLKV
TQQEKHTDSAGPSCTSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVD
MKNYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAW
KVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTPQDASAEVDRIESSSEEDESGLA
DERTSGAVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGERREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCAL
SLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
KIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEV
KGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKV
DGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQR
RNKTKDVSGC
>A0A4Z1J647|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryotinia narcissicola|TrEMBL
MPYDSWISRPIWSIEIDDIVVLWHLYRIPIILTAATILILVRITLRPRTVREKLSASPLP
SSPVLPAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTANSFVESIRGDLSGRAIGQKIQFLESQLLDLSYIDYDDYFINPPKGGSGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHVAKTGSLGEGV
IGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKMQKKDDSLNDLEDIGGVLNNTETID
NTTGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGEDKVAENNTKDGLAF
>A0A7C2L910|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
MGQRLVLDAVKRYLRAGYALVGRHSAVEVCRWTKSALKGGHMCYKRWYGVRSHRCVQMTP
VLNFCNFACVFCWRPHVEGRFEIPASWQWDEPADIVEGAIYAQRKLLAGFKGNPQTTMER
FLEAMHPRHMAISLDGEPALYPKLAELIREVKARGMTAFLVTNGSVPSRLEELIGKGAEP
TNLYVSVYGPSPEVFEKAARPLTPKAWELVMETLDLLPRFSTRTILRLTMVRGLNMVEPE
GYAKLIERAQPKFVELKGYTWVGESQKRLPITAMPTLGELEAFAGKLAELTGYRIKVSDE
KSRVVMLVRDEETWEWNLKLIEEQRALEEKLDAEWKKKVGDFKIRNLPPPPIPVLTPDDL
RRLAGAAGPRPHAGESAPF
>A0A135U5F2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum salicis|TrEMBL
MASTLEPVDFKSMLNNVHDVWQQVRIPVILFTAFGLLVLRFYLHSTEEKSELKALPKAYN
REKPETKPVEEKKKDVKPSPPSPTIDSKAPKTNGPKRIKGGIVRRTSSNGAKGEVLARKV
RPLVFFSSITANTPKIAKAYAEGLEKELQKVAADTDCSFTTPEVLDLAEVDFDDYFITPP
KSEEDPVDLFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDRE
GWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYIERLSEWSEGVVDVLGMLA
KTGSLGEGLPGSGAPEESDDESAAEDDDEVLIEDSEAKPEKLKSRKNIDDVEDLGRIMKS
SNPDAATNGRAAKSATAGAAAPIAVDFTTYGKTVAKKTPLNAAKEMVAKDSPTYASLTKQ
GYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRP
LHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKG
VTYCGTSTASNAGLSMSNVPFYWEVQEFVTALETRLNEKGLKYGIAAEHAHSCCVLLASD
RFYKDGKWHPRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGKGGFDPRDDRVDR
KGRKIEA
>A0A0V1KF96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSV
HDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIKEMLTP
TLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACAN
KCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESSTVR
HCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASK
ESLKEIDRPLFRDFWQRLMNSIDILRDKKQRTVYRLTLVNQYNMNEVSQYASLIKRGQPD
FVEVKGVTYCGDSKNSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKL
NVTIFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPED
QRWYRKSKDS
>A0A6G3LQ16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
MESTQRMEVARYLRAGYKLVGNHSAVAICRWTRSAIRGERLCYKSWYGIQSHRCLQMTPV
LNFCDFACKFCWRMHLPGRFKIPNGWRWDEPEDIINGSIIAQRLLLIGFKGNPKVTKERF
LEAMFPRHFTISLDGEPLLYPKLPDLIKRINERNFTTFLVTNGSIPMRLKEMLKKDAHPT
NLYLSLYGPNKEVFQATADPKIPNAWENVLTSLELLDQFKKSRTVIRLTMVRDLNMVEPE
GYASLIKKANPMFVELKGYTWVGESQKRLPITAMPTLDELEKFAEKIQEITGYKIKVKDD
KSRVVMLVRDKDAWETNLKMVEEWKQKVSKLDENWKSKVEDFTMEEHGYKLLYY
>A0A669D8Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis niloticus|TrEMBL
MWLWHSRLYLYSAAALVFGLWFLLKKKSVSKDSSKEENDKADKAPKKNDRETKEVHVSGV
KIFYGSQTGTAKGFANELSEEVKALGLPAEVIDMKDYDPDDQLADECISKSVCVFLVATY
TDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWL
WMLSGRRIMTRGEGDCNVVKSLNGSIQADFLAWKVKFLNRLKTLAKGEKKSCSGKCKTEG
SCKNKRKERQEEEKKTSPQNNSSEVRAGKFCFLLLPSKDIDVYMAVDHNRLKVLFLPQSK
EESQRDGQMVKLSKLNGVQKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKI
LEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQ
ISSFLVTNAQFPQEIRYNLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALG
EKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWH
QEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYDE
SGGQQTFSALDYVAKTPSWALFGAQEQGFDPAETRFQRRNKSKDISGC
>A0A101H692|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocalculus sp. 52_23|TrEMBL
MRSKACDALRKQGYLFFSPESSAAVKPCMWSKRALRGGDMCYKHQFYGIESHRCIQMTPT
LRCNQRCLFCWRSLEHEVEEEIELAPEVILSGAQKLHKKGLAGYKPHPDVTPERWQAASE
TPNQVAISLSGEPTCYSQLPALVDLFRENGYTVFVVSNGTHPDVVEQLYPTQLYISLDAP
DEDTYTMLCRPKGDYWEQVLQSLSLLSSRRSAVRVTLVKGLNDHSPEAYGRIIADSAPTF
VEVKGYMYLGYSRSRLSMDQMPDHAYVRSFAEKIAESAGYRIRDESPVSRVVCLEEDL
>A0A443HHS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Byssochlamys spectabilis|TrEMBL
MTSSPPEAAAAVAGLLELWHSYRLVILVAITAVGTVTYIYRTAYRRSKTSLSLSTPPSPL
VPSEKIPWTRDSKVVEARADSEFAKLPSKVDLKQNKPTSGPKIVQGKKQVKARGAQRSPE
QSESPFFIQPVIFFSSLTGNTERFAHTVLENLRSAAQAYSKTDRGRGLLPPQMHDLSYID
FDDHFTAAPKPPSSSPNTQYFYCLLIPTYNIDTIINTFLGHLEETHHDFRIDTAPLAPLT
GYSVFGFGDREGWPTEEEGFCSQAKELDRWMAKLTGGKRAYPLGLGDTKSDASSSLAEWS
SGVKEILYDILANGGLGDGVAGSGDAFESDEEDLENTPGESNTRKPRKAAASGSVLDLED
IKFNVESQNPGAGSAPLPVDFTTFGKEASNPITQPAAKEMVPKKSPTYTALTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWKVDPPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLSMLHGEKISSFLVCNAQHPDELAALDRVTQLYVSIDASNRESLRKIDRPLHRDFW
ERFQRCLDILREKRHVQRTVFRLTLVKGFNVDDEITGYANLVEKGLPCFVEIKGVTYCGT
SSSAGAGLTMKNVPFYEEVAEFVVALNNELQRRGLKYGIAAEHAHSCCVLLASERFFIGG
KWHTRIDYDRFFELLEKEKRDGTSFMPEDYTRETEEWALWGNGGFDPNDERVYRKGRNKT
ALPPAAS
>A0A250Y4M6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Castor canadensis|TrEMBL
MGPPLDVWGLSPSLFSWWINRFYIYSGLAFALSLWICLQIIFKKQAKNSQENSTPKATED
LLTNGYITLQKKQIFVSGVKIFYGSQTGTAKGFATILAKEVTSLDLPVTVINLKEYDPDD
HLVEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLG
NSAYSNHFNKVGKNVDKWLWMLGAHRVLTRGEGDGDVVKSKHGSIEADFRAWETKFISQV
QALRKGEKKSCSGKCKKGKCESKQQGSEGTEPGPHPQEEQRHRDVEEEEPCGSTSEEELG
GDNSERPSSVVDVEDLGKIMNHMKKEKREEEHLEEETSLFRGTWKNEDGEGRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIKHHQNMIRQFKGVPGVRAERLEEGMEVKHCA
LSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSL
RKIDRPLFRDFWRRFLDSLKALAAKQQRTVYRLTLVKSWNVDELQAYAQLVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVHFVGELVDLIPDYEIACEHEHSNCLLIAHRKFK
IDGEWWTWIDYDRFQALIQRYEDSGGAETFSAQDYMAKTPPWAVFGANERGFDPKDTRHQ
RKHKSRDISGC
>X0BSD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. raphani 54005|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
PTTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8D5ZGP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stygiolobus sp. KN-1|TrEMBL
MESKSTFRIDTLSVIMKELEKEKYHIVGSHSVYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMSPSAAWCWFRCVHCWRLEPEDIGLDWDETKIPIEDDPDIIAEKSIEEHKRAVSGY
FGREGVPKEKAKEATTPKHVAISLTGEPTLYNRLGELIAEYHKRGMTTFLVTSGVRPDIL
AGLEEEPTQLFVSLQAPNERKHKVINRPIVANSWNLVMETLKILPSFSSPTVIRMTMIKG
FNMSEEDAREFAKLMELSQPTYIEVKAYMHVGPSTYRLTKDAMPRHSEVREFAKLLSDYT
GYKILSEHVPSRIVLLSKLDRPIQIGNAWTDKWDWSTRDVEDDLSGEYKEAEQDCSEGVS
>A0A1V4ZB48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon PtaU1.Bin124|TrEMBL
MKQDLRGILEKQQYKLSGEHAAVKLCHWMKESLLRGRTCYKQDFYGIRSHRCLQMTPAVN
DCTHNCLFCWRVRGFESSVAKWQEPEVVLDHCIESQRKLVTGFKGDPRCSRQMWDEAREP
KQVAISLAGEPTMYPYLSDFIALCHRRGMTTFLVTNGTFPEVLEKMDELPTQLYVTVAAP
NEEVYKRICVPRIPDGWERLMRTLELFPSLSTRKVIRHTLVKEYNMGWEREYARLDAIAD
PMFIEPKGYVFVGDSRTRMTMDHMPAHKDVVEFGARLGRELGMEVLREKPDSRVVVVGQN
GEQTLIPGL
>A0A8H4RLI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cudoniella acicularis|TrEMBL
MDHNAWSSRLLWLLDITEIVAFWHLYRIPIILSTFTVLMIIRTILHLKIPRERLSGTPLL
ASPRLPVEKEKSSIEAAGKKTLGEKVPRRIVGGLKKKSSEDGSRLGDGKIQILVFFSSLT
GTTEKTAKVFTESLQQYTQDLSTSTTFLEPEILDLSYIDYDDYFINPPKSESATQYFYLI
LVPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQA
RDIDKWMSRLTAGKRAFPLGMGDSKKDAGERLQEWKEGVEEVLVHIAETGSLGEGVVGSG
DAVESDVEDVDDGEEVLFEERNVAQRKTKIQKKDVLNDLEDLGRGLGKTDPSEPLEVDFT
TYSKKTRTPATTITKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYK
YSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFAGVKAGHYQK
IKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVGMLHKEHISSFLVCNAQH
PAQLATLAPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNSCLDILKQRRFEQRTVFRL
TLVKGFNIDDEVEGYAALVEQGLPCFVEIKGVTYCGTSSSAGAGLTMQNVPFYSEITEFV
LALTEALQKRGLGYGIAAEHQHSCCVLIASDRFKNDAGKWCTRIDYQKFFELLESGEKFK
PEDYMGGRDTGMGLLGKWRVRSQGRKGVQEGKKQATFTGSQG
>A0A520KYF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanolliviera hydrocarbonicum|TrEMBL
MSQYEEILKKQGHHLVGQNEHSAVKLCHWLKKSLRDEGECYKSKFYGIASHRCIQMTPYI
GCNQNCIICWRPTGMKTSFDEMDSPEEIVEASIKEQRRILTGYKGSYRTNMSKYEGAVDP
KHAAISLIGEPTLYPYLEDLIEEYGKRGLTTFVVSNGTNPEVIEEINPTQLYISLESFEE
EMYKKMCRPNEKDLWERVLESLEILGKKRCRTVLRITLVRGLNFEAERFIPLIELASPDY
IEVKSYMHLGYSRRRLERDRMPTHREIKEFSRILNGKTDYSILDDAEISRVVLLSKDKGE
DRMINF
>A0A7J0EI71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Actinidia rufa|TrEMBL
MPSAAARLTVLAVLSAATVYCFYKSRRLRLLTKLSPSNLNPNHTLSPPKGKLFFVSQTGT
SKTLARRLFDLLTTNGLAFDLVDPKDYEPEDLHKETLVLIVASTWDDGKPPPNGGFLADW
LAESADDFRVGSLLLRVFEADAIAWSSGGFASVGGDVGGGDLDVVFDGWSEKLIGVLKGG
ALENGDKFGYEGGVESDFEVISSSDDEDKDENGEDSGIVDVEDIAGKAPSRKSMTLVRPN
GKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHR
CMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLDIVNSAIDLHTKMIRQMKGVPGV
KAERLSEGLSPRHCALSLVGEPIMYPEINSLVDELHRRRISTFLVTNAQFPEKIKLLKPI
TQLYVSVDAATKDSLKAIDRPLFGDFWERFVDSLKALKEKQQRTVYRLTLVKGWNTEDID
AYSSLFSVGNPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALAQKSEGQYEVAC
EHVHSCCVLLAKVDKFKVNGQWFTWIDYEKFHDLVATGRTFDSKDYMAATPSWAVYGAEE
GGFDPGQSRYRKERHHKSSH
>A0A4V0KAF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium chabaudi chabaudi|TrEMBL
MVTKREDELVLPPNEGGNINTYSIQKKTKINLTIIYGSEGITSYKAAKEFLNELIYFFNN
ILNHFNTISTITKGDNKNNTIFEGSISNEINNIEDYMLEYFRSKLLKTNKKNKDGKFVKK
CKNEKTNNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCSIENNISEIHFDFVN
GNEFDSYTFFENSENNDLNILFMFISTYNFGAFPTNCYKLEDILTDLVNDFRVEKNYLKN
IFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLTLCSTMDNDEEFIHWKSSL
LKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSESINDEEKQASKSVE
NNNIHKCDCIRNGVSSEHLDAAKESGDNHNKLTNKINGHISFSTSKMDANTTEKCGCTSS
NCLNGNDKYINEKEVINNNFETSIVNGCCKNEYEQDGELINSDFSNESMNENNDEINCNS
SEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKAQIRGRGGCYKHTFY
GINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKEL
KGVHNIINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNEL
KKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKERKERTVFRFTLVKEY
NMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSK
RSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNFSAIDYCAET
PEWAVVGAPECGFNPSDQRVYTKGKNKNKNNINTMEVKT
>A0B677|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)|TrEMBL
MDPAALERQGYHLVGEGAVKPCLWLKRSLRGREQCYKHHFYGIESHRCVQMTPVLHCNHL
CLHCWRPVDDSFPLPERWTEPEDLLDLVLREQRRILSGYWGSDVVDRARLQDASTPKHVA
ISLMGEPTFYPHLRGLIKAINERGMTSFLVTNGTNPDVLKDVDPTQLYISINAPDEDTYR
RVSGGRDWNRILESLAMMRDLRCRTVVRITLIRGVNMFNPDAYARLLDAEPDFVEVKAYM
HLGRSRYRLSRDAMPSHEEVVSFASALAESMGYTLEDQVSLSRVALLTRGNVQRKLDKL
>A0A1S9RTK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium brasilianum|TrEMBL
MASSPTLTDGLLAAWHTYRLPLLIALSTLFVALHTYRKVQSRSKTPTSSSIPSSPRSQSP
AKSPILHVPTEKQPPPLIPTNNGKLTHNDQPPKSTSGPKRVQGKRPAKTVTGRRTTSEER
HPLSIQPVIFFASLTTTTERYANVLLEDLRAVAQERADPENRESGLLPPQIHDISYIDFD
DFFAAAPKPPSTSPGTRYLYCILIPTYNIDTVLNTLLGHLDEIHNDFRIDTAPLSQLAGY
SVFGFGDKEEWPTEEEGFCSQAKEVDRWMAKLTGRKRAYPLGMGDVKTDAEISLKEWSRG
LQDTIFDILESGGLGEGVPGSGDAVESDDEELEDLEDGDEPRGKKKDTSTMVDLEDIKMN
GDSAGPIPIDFTTTGKAISAEPTAKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGIKSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIF
DGVKEGHYKKIKMLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHEERI
SSFLVCNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREK
RHIQRTVFRLTLVKGFNVEDEVIGYANLVEKALPGLIEIKGVTFCGTSTSAGAGLTMKNV
PFYEEVSAFVVALNEELQRRGLKYGIAAEHAHSCCVLLASERFHVNGKWHTRIDYDRFFE
LLEREKKDGTSFAPEDYMRETEEWALWGRGGFNPDDERVFRKGRDADSRARKAREILGTA
ITF
>A0A2H1GY27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zymoseptoria tritici ST99CH_1E4|TrEMBL
MGDSHLLQLPQELLLLWHAHRTEILISAGFLVAIVRLTLHWRSTKTKAILTPPLGSPVTE
KPIRFPEVVQEKTVPTAQPVKTNGPRRVKGVKKVKKQEQAKDERPPIDKIQPYIFYFTLG
GSTKAYAEKLAESFILPDAKDRVLPPQVHDLTDIDYDDFFISPPKYDSPGTAAFYTILIP
SYNIDTELHNFLSHLQETHHDFRIDTAPLQTLAGYSVFGFGDMQEWPTEQEGYCVQAIEV
DKWMAKLTGKKRAYPLGMGDVKDDVELRLEEWRRGVQTIVDDLSQGKGLGEGVPGSGDPI
ESEDEADEDYDDGETLITITADLEDIRAPIPVDFTTSKKSTSTTTGPPKEMVPVNSPTFN
SLTKQGYSIIGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCVF
CWRHGSNPVGTTWRWQVDPPEQIFEGILAAHYKKIKSLRGVPGVRSERFAEAMRVRHCAL
SLVGEPIFYPHINQLLAMLHAQHISSFLVCNAQHPAHLAALGPVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFCDCMDILRQKRYSHRTVFRLTLVKGFNIADEVAGYADLVQRARPGF
IEVKGVTYCGTSTSAGAGLSMANVPFWEEVQEFVLALAAELKTRGVQNDGMEYGLAAEHQ
HSCCVLLADKERFYRENAAGEGKWHTLIDYEKFFKLVEMGGEFKAEDYVSAEPTADWAGW
GRGGFDPRDVRVDRKGRPIEQKDEGRVVEI
>A0A0V0URA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella sp. T9|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVLDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENEN
SSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKI
CRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTD
PAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISK
MHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSI
DILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSKDSKITMAN
VPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAE
RFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A0K8SG55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lygus hesperus|TrEMBL
MMLEFLLSINFLGHFLIASVIALLIFKNFCNLYSAETSEPILPTAKRQQKENERQRPQSL
YRNIDTNFRCIEVYFATEYGNTKKLCEKLVEYFTTTKSIDSVLIDLSNIEPEDVLHSKNA
QRKCLSLFVLPTVTDGQPPKAAKWFCKWLSDAATDFRIDKQSQAHVSYAVFGLGNSVYAE
NFNIVAKEVDENLAQLGACRVCKLTLGDEDTSESQNGGLEADFDAWTKVIENVVWSQCTP
PYEVLDTRANEVETSSEEEDVVDIEDLVKPKSKRTNSKSEGAKEMITPQLRGVLTKQGYK
LIGFHSGVKLCRWTKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNP
VGTEWKWKMDDANTILRGALENHYNMIKEFKGVPGVLPEKFAEALAVKHCALSLVGEPIM
YPEINKFCRLLHEEGISTFLVTNAQFPEAIRAMDPVTQLYVSVDASTKESLKKIDRPLFK
DFWERFIDSLKALSEKGQRTVYRLTLVKAWNIDEMQNYASLVALGKPDFIEVKGVTYCGG
DSSKPNSLTMANVPWHEEVTSFVEQLIDLLPDYALASEHEHSNCLLIAHRKFFMDGKWRT
WIDYTKFHNLMRHHYETKGESSFSAMDYVADTPSWATFGSVERGFDPFEKRWHRKNGTKD
ISGC
>A0A8C8RF06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pelusios castaneus|TrEMBL
MDGSLDPWSYFYTHLMSLWLNRFYIYSCAAFGISIWICFHFITTKTKKQDEKSTQKLTPL
KVTQDVLINGYAIPKAKKVYVAGVKIFYGSQTGTAKGFATILAEAILSLNLPAEIINMRD
YDPDDSLAEEAASKNICVFLVATYTDGQPTENAIWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSVYGDHYNTVGRNLDKWLWMLSARRVLARVEGDCNVAKSKHGSIEGDFSAWKAK
FLARLQALCSGERKPCSGNCKKGKCKSKGKQSKEEKASEQENPEVEELFETTSEEESDAE
EHGSHNSVIDVEDLGRIMGHMKKAKKECEVEDEAGRMGPPYQSSGKNEESERKEMITPAL
RDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILREAIENHQSLIKQFKGVPGVRLDRFEEGMVVKHC
ALSLVGEPIMYPEINRFLKLLHRHNISSFLVTNAQFPVEIRNLEPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVALGKPDFI
EVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKF
KIDGEWCTWIDYDRFQELVQEYEKSRGSKTVTAADYLAKTPDWALFGSRERGFDPLDTRF
QRKNKTKDISGC
>A0A6P6YE61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dermatophagoides pteronyssinus|TrEMBL
MRSKILSTLWELAINNKLTSALAVGITLILTTGVYRKLQQNYPKVKKFYKDSKQPKQQQC
NCMKNKPKLKILYGSTAGSSRRLSKKLQQLLKNNDSILQIFESIECICTDQYDPEDELLN
DASNGNYLIILMPTFTGGEPPENARWFCQWIKDAANDFRLSKNALSQLSFAILGIGDSIY
GDDFCLCSFKLTKALKQLSSRCLYKTSVLDRSALESIEDQFQLWYQKILSILIEQETKCC
SSDSSSDSTNYSTFVNVGDDSVNADDDDDDDGEFDEDYAEEYESKRNDQIVTDLEDIVTN
TEKKKSASNNNNKKQPIRDMLTTDLRKELTKQGYKLIGTHSGVKLCRWTKSMLRGRGGCY
KYTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWKWNMDPPDMIFNNTMNAHYA
MIKQYNSVPGVLPERIDEAMHVRHCALSLVGEPIMYPEINEFIRLLHSKEISTFLVTNAQ
FPDEIKRLDPVTQLYVSVDASSKVSLKKIDRPLFRDFWERFNESLRLLSFKGQRTVYRLT
LVKSWNSEEIDGYAKLVILGQPDFIEIKGVTYCGTSMNESNLTMKNVPWHEEVVRFGKDL
LEIINQQIKQRKLNQSGISGYSENFDSELYGLACEHEHSNCLLLARRKFYINNQWYTWID
YSKFNQLIQEYYRTNGERTFTSIDYLAPTPKWATFGASEQGFNPNDTRFRKKRNHTYDKN
>A0A0B7A5C3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arion vulgaris|TrEMBL
MLEKFIWHVPLWAVLAAGIGVVWLVNRKKQAKNKDEPINETSADTTSRITKQKRKLTILY
GSQTGKGKVFAENVQTKVEAAGFIATVADLSSYDHENLFQSEAEEGNICILVVSTYTEGQ
PPEGAKWFYTWLEDMAEDFRVTKATLAGLNFAVVGLGNSLYPDHFNTVAKNVDLWLHTLS
ANRILPLCLADENVILSKNKGLQEDFNVWLESSMKNLRRAIRGREVTAKNCEDTCKKGCS
CKTDKNGDGDTGGKCSSDEEVEDEVLSDDSEDDLSTPAPKHDVVDLEDLGSLFKQSKNNK
LVNGDAGGHGDGPREMITPLLRESLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTF
YGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWKMDDAQTVFDGAVSNHIKLIKQ
FRGVPGVLPDKFDEAMNIQHCALSLVGEPIMYPEINKFVQLLHSKHISSFLVTNAQFPQE
IRDLLPVTQLYVSVDAATKDSLKKIDRPLFKDFWQRFIDSLTALRDKGQRTVYRLTLVKA
FNTDELDNYAKLVSLGNPDFIEVKGVTYCGESKASTLTMENVPWHEEVVRL
>A0A8B9QHF0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apteryx owenii|TrEMBL
MDPWNFFYTCLTSLWLHRFYIYSSVALGISIWICIQFFTSKTIKKDEKFNGNPASAEVAE
DKLVNGYATMKAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVTSLNLSAEVINMGDYDPD
DSLTEETTSRNICVFLVATYTDGQPTENAAWFCKWLEETANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLGR
LQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDHEHGASEYENAEAEEFFETTSEEESNA
EEAGDTNSVIDVEDLGKIMSHMKKAKKERELEEGGGRTSLSQESAGRKEEGERREMITAA
LREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKH
CALSLVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKD
SLKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDF
IEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKK
FKINGEWCTWINYDRFQELVRDYERSRGSKTFTAADYMAKTPHWALFGSRERGFDPLDIR
YQRKNKTKDISGC
>A0A8B9SF67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apteryx owenii|TrEMBL
MDPWNFFYTCLTSLWLHRFYIYSSVALGISIWICIQFFTSKTIKKDEKFNGNPASAEVAE
DKLVNGYATMKAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVTSLNLSAEVINMGDYDPD
DSLTEETTSRNICVFLVATYTDGQPTENAAWFCKWLEETANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLGR
LQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDHEHGASEYENAEAEEFFETTSEEESNA
EEAGDTNSVIDVEDLGKIMSHMKKAKKERELEEGGGRTSLSQESAGRKEEGERREMITAA
LREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKH
CALSLVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKD
SLKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDF
IEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKK
KIQMCALPHRTWESGSQRDALQVLCCFRTEMLQQTRMP
>A0A087YD95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia formosa|TrEMBL
MLALFTVISFFTGSLSASDTKVPPDVHSPTENYLLWMWNNRLYVYSAAALLLGFCFLLQV
TRRKINHTKDSGSKDSGLKVQKAAKNSSDEDADVHVSGVKIFYGSQTGTAKGFASELSQE
VQALGIPAEVIDMKDFDPDDRLADECVSKSVCVFLVATYTDGRPTQNAEWFCKWLEEAST
DFRYGNSFLKGLRYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSARRVLSRGEGDGNVVKS
RHGSVQADFRAWKVRFLSRLRALARGEKKSCSGNCKSGASCKNRKKHGAPEEEEHGSEVE
LIESSSEEEESGWPDEKTSRSVVDVEDLGNIMNSVKKAKGVKGEQGGQMVKLSKHNGVMK
TEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESH
RCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPG
VKPERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPEEIRNLVP
VTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVEEL
QAYAELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPHYQIAC
EHEHSNCLLIAHRKFKVNGEWRTWIDYDRFQDLVQAHEDSGGQQTFSALDYTAKTPSWAL
FGSNEQGFDPADTRFQRRNKTKDISGC
>E0SP26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans (strain DSM 17230 / JCM 13409 / AQ1.S1)|TrEMBL
MYSDHIMFRLMKNDIDPITQALDILRKQKYHLIGNHSAVKKCYWVHKAITEGMFCYKAKF
YGIESHRCIQFSPSVLWCWNYCLHCWRYRSSDSGENIWHVFPSHVDDPRFLVDMAIKEHR
RTVSGYKRYPNVDKRIYEEALNPKHVAISLTGEPTLYPRIDDLIEEFHKKGMTTFLVTRG
VRPEILANLRVEPTQLYVSLEAFDEESYRYFNNPISPQLWRKTLETLEILPSFTSPTVIR
ITLIRSFNMHNKAIDAWSKIIERSQPTFIEVKAYMHIGASITRLSRDDMPNHYEVKRVAE
ELSKRIGYNIVSESIPSRVVLLSKLDRPIIRYGNPPISWSDIDKGDENSGEYGELSPP
>A0A2G4T7V8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus microsporus ATCC 52813|TrEMBL
MICRFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAANIDKWLGRLGATR
IYPLGECDKNADQKAQFDVWSNGFISELQDKHTLEFAPTNIAYQSDDDDEEAEEAEAIGS
EDEMVDLEDMGKMATKIKAAKAKRAEEEEDFENSKAKAKRAIGEDAKKQDKPQAREMVSP
MILKNLTKQGYKVVGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSLACAN
KCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLKGVPGVKAERFQEAFTIR
HCALSLVGEPIFYPHINDFVNMLHERNISSFLVTNAQFPDKIAEMVPVTQLYVSVDAATK
ESLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNTEEIDGYVELIRRGKPS
FIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRKLVSKLDGEYEISAEHAHSCSLLIAH
KSFKVNGEWYTHIDYPKFFKLVKSGKPFTSLDYMAKTPEWAVFGHEAAGFDPDETRFYRK
NRKNVEPPVIKTEA
>A0A256ZZ83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon ex4484_14|TrEMBL
MIINEETIKKLEKIGYRFAGPSKHSAIKICNWTRESLRGRNVCYKEKFYGISSHRCLQMT
PALPFCTQRCRFCWRDTNITYPEWAGPIDDPEQILDDCINAQREILQGFKGNPKVSEKKF
KEAMNPNQVAISLAGEPTLYPKLPEFVDLVNSRGMTSFLVTNGTRPEMIERLLEHQPYQL
YITVAAPDEEIYKKTCQPIISDGWTRLKKSLSMLSQFNRSVIRLTLVKGLNMIKPEQYAE
IIEKTNPRFVEAKAYMAVGFSRERLGLKFMPRHEEIMKFAEAIEQNSSYKITDEKKESRV
VLLTK
>A0A2T7A7K9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tuber borchii|TrEMBL
MAESQNNTAQLLELWHSFRYLLLLLGVAGVFVLKLRSYIRNFEQREGKGLTALKPTTWVQ
VPVKAESKPSVKTHITPRRIVGKRGLKPKNGGKAASEVEEGEFDIQTLIFYSTLTGSTQR
CAEELRTRLFGVKGESIYPTLSIPTPSNSLVSVPIRRSFLPPAVYNLEEVELDDFFVTLP
NENGKKVKYVYLLLLPTYETDAPIRPFLEHLRETHHDFRIDTAPLRSLAGFSVFGFGDSS
EWPAEEGKFCKDAVEVDKWMGKLTGGKGGTRRMFPVGMGDVNPAVGPNSAEKSLDEWRVH
LEDAMREYAATGALGDSADWRTAIESGDEDSDFEIVDPADDMVDVEDLGNVIRTDPAVAK
KGNVVKRKAVLPVDFTTLAGRKALEAGEGQSADRKEMVPKGGVTYETLTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WKVDPPEEIFKGVVEGHYRKIKMMKGVPGVRADRFSEAFKIRHCALSLVGEPIFYPYINE
FLHLLHSSKISSFLVCNAQHPAQLAALGHVTQLYVSIDASNKDSLKKIDRPLHRDFWERF
QQCLDILREKRNQHRTVFRLTLVKGFNIEDEVQGYADLVEKGLPCFVEVKGVTYCGTSTA
GEAGLTMKNVPFYEEVVAFVEALNAELSKRGLGYGIAAEHAHSCCALIASNHFFINGKWH
TLIDYAKFFELLESGKEFGPEDYVGEATPEWANWGNGGFDPADQRVYRKGKGPKEEVEES
GGCG
>A0A673BWP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
VLTPLETVFTFPALSYITSIWHNRLYLYSAAAVFVGIWISLKMGLKKQSLSADTAPKVYK
AEKKNGCSDRDAVVHVSGVKIFFGSQTGTAKGFAKQLSEEVQTLGLTCEVIDMKEYDPDD
RLADECTSRSVCVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYAVFGLG
NSVYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVKFLNRL
QNLVKGDKKSCSGNCKNGGSCKNKRKDGHGQEEEEDAVTRQNDGSEVMDGRLLSHGWCLK
AKVVLEGQMVKLSKLNGVKKVEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKI
LQDSLEKHENMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSHR
ISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFQDSLRALGE
KRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQ
EVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQVHEDS
GGQQSFSALDYVAKTPRWALFGAEEQGFDPNDTRFQRRNKTKDISGC
>A0A2P6VWJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon SW_10_69_26|TrEMBL
MREELERLLEKQGYGFAGDHGGVKLCHWTKEDLKEGGRSCYKGSFYGVESHRCMQMTPVV
DYCNFRCLYCWRSQDFDTSPNGRVWDDPEELFEDSVNEQQRLMSGYKGQDVTDMEKWVKA
NRPKHVAISLNGEPTVYPYLADFIEMCHDHDMTTMVVTNGSFPDQIRTLAEEDALPTQLY
VSVDAPNEEIFEKLCVPMNGGAWDKLNETLKLVSDLDCRTVARHTLVKDWNMGHYDEYAD
LIEKADPDFIECKGYVYVGYSRQRMKEENMPTYSEIRQHANRLAERIPHTYEADREDSRV
SLLVHPDAERRIPKAADEELDPIDVTDDVSVGVNENGAGGCGTACGCASM
>A0A7J9KU50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium schwendimanii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELENVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGEDIVDLEDI
AGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTA
IDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTF
LVTNAQFPEKIKMLTPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQR
TVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVRA
FSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFDS
DDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A507ES72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spizellomyces sp. 'palustris'|TrEMBL
MSFILSLLDVTSWSAPSWILIATLFLALWIVNKQNLSPSKVESQIQAPVKPTANGGQSKI
KSYSTSPKQRRAKKEDNSAKVTCGCCNVEEDEGCCTSNSGESCCKSNTKPAPPTTATATT
FENVQDSEDTEEIDDSKRITLKILFATQTRTSRTLSYRLKELVEANVPLVKEVQVLNISD
YENEDLMTEKSPVVFFLSTYSEGSPTEDAAWFYQWLEDTRFDHRVNKQCMKSLRFAVFGM
GDSVYEENYCTVAKRVDKWIGELAGRRICPLALGDKSDDTEHQFITWTKLFLSRINGVAN
HLSIAGEDNLDDFVEEGNYESSEEEEEEAETSSGDELMDLEDMGAMAAKIKSAKQQRTEE
EAALSLEKGGPKRRIGTRDAEERPEKLIKEMVTPMLRKSLEKQGYKIVGTHSGVKICRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRQHTNPVGTEWRWKMDDAVD
IVDGAMENHYKMIKQLKGVPGVKPERFEEAFTIKHCALSLVGEPIMYPKINEYVDILHSR
NVSSFLVTNAQFPDAIENLKPVTQLYVSIDAGTKEDLKKIDRPLFRDYWERFLACLDALG
KKGQRTVYRLTLVKDKNDNTLDSYVTLISRGNPDFIEVKGVTYCGFSGASHLTMKNVPYH
YEVLTFCKDLCERLGGKYEVACVHEHSCSVLIADKARYYKDGGWWTWIDYNRFFELIREG
KPFTSEDYMERTPDWGVVGDERGGFDPEETRFYRKGRIPVAVGEEGQR
>A0A133VBC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA261F19|TrEMBL
MVISPGAKADLEHSGYRIVGENEHSAVEVCRWTKKSILNEGVCYKEKFYKDLQGIESHRC
IQMTPSLPFCDNKCVFCWRNVDLTHPSWRGEIDEPKEILDEAIEAQRSLLSGFKGNPDAD
RSKWEDAQRPTLCAISLAGEPTIYPKLGGLIEECNRRDISTFLVTNGQHPECLETITEPS
QLYISAVAPSEKTYVRVCRPLLQDPWRRLNDSLELMPSFDCIKVLRFTLVKGWNLEDPSG
YAKLVEKAEPDFVEPKGYMFVGHSRERLEMDNMPNHSEIKEFANKLARETNYEVSDESEA
SRVVLLKK
>A0A830ED60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulcanisaeta souniana JCM 11219|TrEMBL
MEKIEQTVRESLKYHIISEVNGRIRIRITDETKARLIKASYGIYNHSTVELCHWTKSALV
KGQSCYKFKFYGAPAGGSHRCAEFSPVGMICSNRCVYCWRPTDSFDSLIPTTDLVDDPEE
LIQGVLRERYRLLTGYFGNPKSKERAKEALVPTHWSISLSGEPTLYPKLPQLVKYLKSLP
NTKSVFIVTNGEHPEMLERLQQEGTLPTQLYLSCNAPSKELFYRINVPVMRREDAWERWL
RSLELLSKLNTRTVIRITLIRSLNYDFKYVPEFAKLMLIGNPHFIEVKSYMHLGHSTFRL
TRNDMLKHEEVREWAMRLLEDINRLGGDFRYMDEDEPSRIVVLQNMSRYIDRWIVKPEDQ
VKIR
>A0A2H5V5K4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon HR02|TrEMBL
MAEKLSEPRRIVRLEVRGVEKFIRSGYRLVGRHSAVKICHWTKSALRGGKSCYKSWYGVE
SHRCLQMTPSLQYCNMACVFCWRFHTINRGQPYLGEWDPPEALLDAMIREQRQLLSGFKG
NPLVERRKFIEAMTPTNIAISLDGEPTIYPYLAEFIKLARSHGMTTFLVTNGTMPERLQE
LLEKDAEPTNLYISFYGPDKETHLSVNKPLIPDSWERVWRSLSIMPRFKCRKVIRLTLVK
YLNLKSPEKYAEAIRTAKPDFVECKGYVHVGESQKRLRKEHMPSIEDLMEFSQELARLTG
YVYATHDEVSKVVLLANPTSPYYIEARERLARAQTSNVEVPAASCGENIL
>A0A2H4SM70|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cordyceps militaris|TrEMBL
MDPLGSGYGQSALFNINGLLDVWHTNRTPIILFALCGLLVLRLYLHVYEEKSDLKTIPKI
YEKANPQNSDTVLPRQVQEKTLVKAAGPRRIKGGVAKKSETSEEPVDLNKPVKILVFFSS
ITTKTEKIGRDFIARLEKSVTQIAAETKRPVLAPELLDLTEIDFDDYFIAPPTSDVGAQF
LYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREGWPDEAEGY
CFQAKELDKWMAKLTARKRAYPVGMGDMKSDHAERFIEWTSGVEEVFDHVIRTGHLGQGV
PGSGAAVESDDEIEEDYDDGEVVFDEGNPPKRENGKTSSSLDDVEDLGRVIKSQAGDANP
KAPIAVDFTTYNSKGNAQSKVKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWTKSALR
GRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELIFDGV
KENHYKKIKMLRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKERISSF
LVCNAQHPDELANLKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNRCLDILREKRFR
HRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLTMSNVPFY
WEVCDFVRALDKRLQEKGLAYGIAAEHAHSCCVLLASERFHVNGKWHTHIDYDRFFELLE
ERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVIREAPE
>A0A8H7QLD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor saturninus|TrEMBL
MSNFINSLITGFSNILTVGPEGAKEEGSCGNGDSCCKDQPAKKKEGGCQSDACCSTPTQV
KKEKTGCCSDNKEENSSNGCCKTEVKKEEVAAGGCCSGKEEACACEGEQGPVVIENLKII
FSTLTGTAKTMASEIEKKVKDNTRVTVNKIDIMDITEYDNDNLLQETAVCIFILSTYNVE
GPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNLAAANIDKWLGRLGAT
RIYPLGECDKNADQKGQFDTWSNGFVSELEDKHSLEFSPTDISYQSDEEEDEASGEEADI
DVDGGSGDEMVDLEDMGNMATKIKAAKAKRAEEEEDFENSKAKAKRMIGVDDNKPRERAV
APQAREMVSPMILKNLTKQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCM
ETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQLKGVPGVKA
ERFQEAFTIRHCALSLVGEPIFYPHINDFVTMLHKKRISSFLVTNAQFPDKIAEMVPVTQ
LYVSVDAATKDTLKKIDRPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAEIDGY
VELIRRGQPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCQKLVAKLDGDYEISAEH
AHSCSILIAHKNFKVNGEWHTHIDYNKFFELVESGKPFNSLDYMAKTPDWAVHGHEAAGF
DPDETRFYRKNRKTVEAPSNPDINA
>A0A3R8CDX7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosalsum natronophilum|TrEMBL
MEKTDKSSDLDFNLLLKKQGYLLAGTHSAVKTCLWVGRSIKGEGDCYKSKFYGIQSHQCM
QMSPTLICNQKCLHCWRPTETKIEYPKKWDSPLDIVEKSIASHRKLISGYGGSGKRNLWV
EANTPKHVAISLAGEPTIYPYLPQLVEEFKQRKITTFVVTNGTNPDMIDELNPTQLYMSL
DAPDVSTYHKVCSPCSNGFWDKINESLAKMKKKKGRKAIRLTLIKNLNMFNPSLYAKLIS
QADPDYVEVKAYMHLGFSRKRLPRESMPSNEEILNFSKELANQLDYIVIDNVETSRVVLL
AKNGNTQINNFFI
>H2YWM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ciona savignyi|TrEMBL
SIVHILFGSQTGTAASYAHAIQEELNGKGIKSKLEDLKNFDPEDNFLYWNESKMNGPVLF
LISTYTDGTPPPSCEWFCRWLQDASNDFRVNKSLLSNMRFAIFGLGNSLYSDHYNTIGRN
LDRWLHKLSATRIFPFTAGDENVVQSKHGSIKLDFNAWKSEIISVLEYLLAGNQKNGVVT
PVAEIDSVSSTTQCLVCTIHNPHQQEEEEEEEEKGEEGEDVVDVEDVGDAMSHYPLLTKL
VYLFLICFVDWQGLPQQIKCMRKRNSKKPPEMITDELRKSLSKQGYRLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWKWKMDPAV
DVIKGAIENHYDMIKQFKGVPGVKADRFAEGFSIKHCALSLVGEPIMYPEINDFIQMLHE
KGISSFLVTNAQFPEAITTLLPTTQLYVSVDAATQDSLKKIDRPLFKDFWPRLIESLKAL
SLKVNIYYHLVPQGQRTVYRLTLVKAWNVDELEAYADLVALGKPDFIEVKGVTFCGDSKS
SDGLTLKNVPWHDEVLHFVSQLTDMLDGYEIACEHEHSNCVLVAQTKFKSANGEWRTWID
YARFHELFQRFRATGESFTALDYTATTPAWAVLGADERGFDPQETRWRRKEKVTQGC
>A0A7C2XF63|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolinea sp|TrEMBL
MLPEQCKPLRKQGYQFVRPDASAAVKPCLWCKKALKDGDMCYKHQFYGIESHRCVQMTPT
LRCNQRCLFCWRSFEHVFPEETECSPQEIVDAVPRLQKKALSGYKVSPYVRKERFLEALD
PKHVAISLSGEPTLYSRLPELVTLFNEKGYTSFVVSNGTRPWVLEDCNPFQLYVSLDAPE
RETYLKVCRPDEDYWDYIMQSLSMLGKKRSAIRITLVRGLNDHMPELYGRMVQDSGATYV
EVKGYMFLGYSRKRLTRDRMPPHSHVRSFAEQVAACTDYEVLDENQASRVVCLERRR
>A0A6J8A5F7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilus coruscus|TrEMBL
MLEKLLSSYIFESFQIPVWTLLLATICLIWMWNSGRKKENSSEKVEDQKSTELPVTNEKV
IELHANSRQKITKKRKIKIFYGTQTGNAKMLADNLYREATERGHEAEVIDLKTYDPEDNL
VTEGENGVWIVLFVSTYTDGTPPEGSEWFCKWLEESSTDFRIPKALLKDLHYAVFGLGNS
LYTENYNAVGKKVDRFLKELSAKPILPVGLGDENVAESLKGGMEKDFTAWKKEFWKKSKK
VKDDVTAVKDTCGTGKKTCDGKCKCKEDGGKCSSEEEDEEGSTSLTPLYVFKNIKVYNIS
EISDLYETTTEEEDNAEELLNEDGDGSSLQTTNGVVDLEDLGKVMQTMKNAKVRRKKEES
AQSTGEPREMVTPMLKKALEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIESH
RCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDDPNTIFQGALDNHVGLIKQFKGVPG
VKPERFAEGLEPQHCALSLVGEPIMYPEINKFIELLHGKGISSFLVTNAQFPDAISNLVP
VTQLYVSIDASTKDSLKKIDRPLFKDFWERFIDSLKALSAKRQRTVYRLTLVKAWNTDEL
DNYADLVSLGKPDFIEIKGVTYCGESKASSLTMQNVPWHEEVVHFVKQLTDRLEGYEIAS
EHEHSNCILIANTKFKVDGEWWTWIDYPKFHQLVKDFNESQKTFSAEDYMAKTPSWAVFG
AKEQGFDPVETRFFRKKQKDIGGC
>A0A8C7BKY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neovison vison|TrEMBL
MDPAGAWDSASPWVSLWTNRFYVYVGLACGISLWICFQMVVRRRDKSSQERSVPKASQDL
GTDGSISLQRKEVSVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVVDLKDYDPDDH
LVEEVTGKNVCAFVVATYTGGRPPHSAQWFYRWLEEAAGDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWTLGAHRVVARGEGDCDVANSTHGSIEADFRAWKARFLARLH
TLEKGEKKPCAGSCKRGQCESSAEEEPFESTSEDESGAEDRPNPNPVVDVEDLGRIVSCA
KREKREKEQPEEKSGLLRSSGKNGPGERRAMITPALREALTRQGYQLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEV
ILKESIENHQSMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLTLLHEC
KISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALA
AKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKFKVGSEWWTWIDYDRFQELVR
EYEHSGGSATFGAQDYMARTPPWAVFGARERGFDPKDTRYQRKNKSKDISGC
>A0A672LMR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus grahami|TrEMBL
MVDPISPLLYKSVKNQELSPETEKVLYVSGVKVLYGSQTGTAKGFAKELAGGISAQGIQC
EVIDMKEYDPEDRLAEECTSKMVCVFLVATYTDGQPTESTEWFCKWLEEASTDFRYGKTF
LKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQAD
FHAWKTKFLNRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSERMEGD
EEDSQRVKLSKQNGVRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCVPGVRPERFEEGLTVKHCALSLVGE
PIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRP
LFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLISLGQPDFIEVKGVTY
CGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGKWW
TWIDYERFQELIQEYEESGGTKSFSAMDYMSKTPSWAIFGAGERGFDPLDTRFQRKNKTK
DISGC
>X6N293|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Reticulomyxa filosa|TrEMBL
SSSSSIGKEGERKVVLQDMSCTDPEDLDKAGVVLVVASTYENGEPPPNAKFFVDHLKDLT
QDYRVHKHWLQKVHFAVFGVGNSLYADKFNVVGTNIDQYLGALGAKSLLPLYRGDENAAR
MKRGDLDSDFKEWTKSVISALNKVHSSTEKNEAAEASIKTKSSSKGGETKHINTNNNNDN
GSDDDDDDDDERDIKKGEVDGEELTEIEDIGHVFVKSQKTTAVAKKHKSEPQTKKKEEEN
TKEKEEEEEQEEEEEEEEEEEEEKDKQDENGTSTKATREMLDDRMRENLTKQGYKLIGSH
SGVKLCRWTKAMLRGRGGCYKHTFYGIMSYQCMEMTPSLACANKCVFCWRHHTNPVGKDW
KWTMDNPSFIVSNAMQQHAQMIKEMKGVPGVRPERLAEAIRIKHCALSLVGEPIMYPKIN
TIIDLLHKEQISTFLVTNAQFPEAIEALNYVTQLYVSVDASDPDSLKKVDRPLFKDFWDR
FMRSLKALRSKQQRTVYRLTLVKDNNMDGIANYARLIAVGQPSFIEVKGVTFCGKSDGSD
LTMANVPFHFEVKAFCQRLVQYLESDYELACEHEHSCCCLIAHKQFKVDGEWHTWIDYDK
FHQLIQAGRPFTALDYMKKTPSWAVWDSKEQGFNPAETKFVKEKQKQTKASSKYQAKMDK
ALDETNEEATKFFDHLKSNENPYLAEKQAQLLTL
>A0A8C6HSJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mus spicilegus|TrEMBL
MGPLDVWDLSPLLSLWMNRFYIYMGCALGLTLCICVQIIKKQGFAVVLAKAVTSLDLPVA
IINLKEYDPDDSLIGEITSKTVCAFLVATYTDGRPTESAEWFCKWLEESANDFRFGKTYL
KGLRYAVFGLGDSAYRSHFNKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADF
TAWKTKFISRLQALQRGEKKACGRNCKRGKCESAQHGPGEARPHPQGELHPGDAEEEEPC
ESSSEDSEDELGTQDYQSLTSVVDVEDLGNIMNPVKREKREKSHQDGKAAMQRNPEKTED
GEGRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
ATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAE
RFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQHGISSFLVTNAQFPEEIRKLIPVTQL
YVSVDASTRDGLKKIDRPLFKDFWQRFLDSLKALSAKQQRTVYRLTLVKCWNVDELQAYA
ELVSLGNPDFIEVKGVTYCGESAASSLTMANVPWHEEVVRFVRELVDLLPDYEVACEHEH
SNCLLIGHKKFKIDGEWWTWINYSRFQELVLQYEESGGSKTFSSRDYMARTPQWALFGAR
ERGFDPKDTRYQRKNKTKDISGC
>A0A672IHN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarias fasciatus|TrEMBL
YPIQFTLFVVFSVPPDSEDVSPPSQPSLLSLWHNRLYLYTAAALILGMWLSLKMQNLSSE
DVSFISKVERNSHQPHKEIEVHVSGVKIFYGSQTGTAKGFAQQLCQEVKALGLPAEVIDM
KDYDPDDQLADECVSKTVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKTYLEGLR
YAVFGLGDSVYVGHYNTVGKNVDKWLWMLSAVRIMTRGEGDCNVVKSRSGSVQADFLSWK
VRFLSRLQALVKGEKKSCSGNCKTGGSCKNKKRDEEQQQEEEEEEEEEEESSSDEDESGL
QERKPGSVVDVEDLGNIMSSVKKAKSREEVRVKLSKVNGVKRMEDEGERREMITPALRNA
LTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDPAHKILEDAVEKHQGMIRQFRGVPGVKPERYEEGLAVKHCALS
LVGEPIMYPEINAFIRLLHQQHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKK
IDRPLFKDFWPRFLASLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVK
GVTYCGESSASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVE
GEWWTWIDYQRFQELVEAHEESGGQRSFSASDYMAKTPSWALFGAREQGFDPADTRFQRR
NKTKDISGC
>F8AKF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)|TrEMBL
MKMNKTENSNGNKYIPKEIYNILRKQHYQIKDHSAVKLCGWVRKSLLENKNCYKSKFYGI
ATHRCIQCTPSVIWCQQNCIFCWRVLPTDLNDDNDKFNKNIYYKLPKWKEPEEVMNDIFE
MHRTIIMGYKGILDRIGEKKFNEAINPKHVAISLSGEPTIYPYLDELIKLFHKKGLSTFV
VSNGILTDVIEKINPTQLYISLDAYDLDSYKKICRGKETQWEKILNTLDILESKKRTCLR
TTLIRGYNDNIEKFIPLYEGANTNFIELKSYMNVGYSRKRLNLDDMLRHDEIINLSKTVE
ENSFYKLEDDAFDSRVSLLVNENRRINPKIKFE
>A0A0A1SSK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Torrubiella hemipterigena|TrEMBL
MSGSWIGGLASNAVEGWHAHRTPIILCTLATLAALRVYLHLNDDGVELNALPKLYEKEKT
GTKPKEASPTTKASGPKRIKGGLAKKPSTESNEVDLTKPIKVLVFFSSITTKTEKLATAY
VESLSKRLAEITASTGRKTLAPELLDLAEVDFDDYFISPPKEAEPTAYLYLFLLPSYNID
SINDTFLEHLQETHHDFRIDTAPLAPLLGYAVFGYGDKEGWPNENEGFCFQAKDVDKWMA
KLTGRKRAYPVGMGDMKSDHVERFAEWASGIEDTIRHIATTGLLGEGIPGSGAADESDAD
VEEEYDDGEVVFDDEEVATQKNSSSRGLDDLEDLGKMINSSTAGDKKSKKAPIAVDFTTY
GKTTAKPNHPSGAKEMVAKNSPTYTALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKY
SLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWVVDPPDMIFDGVKENHYKKI
KMMKGVPGVRAERYSEALQIRHCALSLVGEPIFYPHINEFLALLHAERISSFLVCNAQHP
DELAALKAVTQLYVSIDASNKESLKKIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLT
LVKGFNIEDEAEGYAQLVERGLPCFVEIKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFAR
ALEKRLEAKGLKYGIAAEHAHSCCILLASERFKVDGKWHTHIDYKRFFELLEERGADGDW
TPEDYMGPPTPEWALWGNGGFDPRDDRVDRKGRKKEAIVVREAPE
>A0A194X882|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mollisia scopiformis|TrEMBL
MAHHTWVLRFLLPFEIADIVALWHTYRVPIIITTFSILIILRTILHLRVPRVKVSDTPPL
SPKLPAEKEKVPIEERNVVAEKVPKRIVGGLKKKKSSQDENPSTIQNAQVLVFFSSLTGT
TEKTAKVLTEGLAQSTKELSKSTSTTFLEPQLLDLSYIDYDDYFITPPKSEENTQYFYIL
LIPTFNIDTVLDNFLEHLQETHNDFRIDTAPLSSLLGYSVFGFGDREGWPTEEEGFCSQA
REVDKWLAKLTGRKRAFPLGMGDSKVDATERLQEWKEGVEDVLANIATTGGLGEGVVGSG
DAVESDVGDLDDEDEVLFEEQKVAQRKTKAQKKDTLNDLEDIGSTLNQITADNSEPLEMD
FTTYSKKARSAPTTVTKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSC
YKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFEGVKAGHY
KKIKMMRGVPGVRSERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNA
QHPDQLRALQPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQACLEILREKRFQQRTVF
RLTLVKGFNIDDEAEGYADLIEKSLPCFVEIKGVTYCGTSSSAGAGLTMQNVPFYTEVCA
FVEALNSSLNRRGLGYGIAAEHAHSCCVLIASERFKVDGKWRTRIDYGRFFECLESGRQF
RPEDYMGEETPEWACWGNGGFDPRDERVDRKGRRKVLPVATAGEEACGGGGGGEGEACAM
ESRDE
>A0A497NUD8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MEALVPSSLIQALKRQKYHLVGRHSAVKRCRWLYETLIHDRPCYKQKFFGIKTHQCIQMT
PAVFYCTQQCLYCWRAQSGDLGIKWNELKLPKWDSPEEIVDGCIKAQLEILSGYKGNPKT
NKQKFKEALTPRHAAISLAGEPTLYKPLGDLIRVFHKKGFTTFLVSNGTLPSALANLNEE
PTQLYISVSAPDKKIHKELCRPQISKAWENLNKTLELLPSFKCPTVFRITSVHGVNMKNV
EGYAKLVEKANPTYIEPKAYMHVGFSTSRLGYENMPSHREIREFAEKLAEETGYKIIDES
KDSRVVLLSRLEKPIKFGSA
>A0A7J3V1I7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPDTLIEALKKHKYHLVGRHSAVKRCRWLHESLVHGRPCYKQKFYGIKSHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETKLPVWDPPEEIVEGSIKAQLAILSGYKGNPKVD
PQKFREALRPRHAAVSLTGEPTLYEPIGELIHAFHKRGFTTFLVSNGTVPSALAKLSHEP
TQLYVSVCAPNRELHKKVCRPILPDAWEKLNETLELLQSFSCPTVIRITAVRGLNMGNVE
EYAELIEKANPTYVEPKAYMHVGFSRFRLGYGGMPSHEEIREFALQLAKATGYKVINESE
ESRVVLLSRLEKPIKFSSD
>A0A8B9YPU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus grunniens|TrEMBL
MFIPNEVGRRLKLDGYCVYFKNKNSPEKTTPKASQNLMTNGYISHPKKEVFVSGVKIFYG
SQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDDRLIEEVTSKNVCAFLVATYTDGQP
PESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLGNSVYLSHFNTVGKNVDKWLWMLGA
HRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRLQALCKGERKHCGGNCKKGKCESNQ
RGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESDTEDHLSSNPVIDVEDLGKIMDHVK
KEKREKEQLEGETSAIRSTVKSEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMI
LKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINKFLKLLHECK
ISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSLKKIDRPLFRDFWQRFLDSLKALAA
KQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHE
EVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFKIGREWWTWIDYSRFQELIQEYEDS
GGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRKNKSKDISGC
>A0A1V5AII3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaU1.Bin016|TrEMBL
MDSPDNIDGIEAKKTLAKQGYHLVGSGAVKPCLWLNRSMRGGDQCYKHHFYGISSHRCVQ
MTPTLRCNHLCLYCWRPIDSVLPEEEPMEPAALLDGILHEQQRILSGYGGAKTTDRSRLK
EALEPKHVAISLMGEPTIYPYLQELIDLISRRKMTSFLVSNGTNPEVLESIRPTQLYISL
NAPDEGMYRRISQPNGPFWPKIQESLSILKNHNCRSVVRMTVARGLNMERPVDFARLLES
AEPDFVEVKAYMHLGRSRTRLDRQAMPDHAEVLSFARALGNEMGYELSMDVPLSRVALLS
SGRICRSLDS
>A0A5B9M307|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp. KEPCO-1|TrEMBL
MYAEKSQRRMEKMGYRFVGENRHSAVKTCLWTKKSIINEGVCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTETAWNGPHDEPADIIEGAIEAQRKLLCGYFGNERADKIKVL
EAQDPTNAAISLAGEPLLYPDMDGLLAEFHKRNFTTFLVTNGLASSNLEALSVEPTQLYI
SLDAPDRETYEKLCRPQIPDAWDLLNRSLEIMPSFNCRKVLRITAVRDINMKKPEMFARM
IERAQPDFVEVKAYMYIGYSRKRLEIDNMPLFYEVHEFADSIAESCGMEIVDESRESRVV
LLA
>A0A232M0D2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Elaphomyces granulatus|TrEMBL
MSADSTAVEAQGLLAFWHSFRIPILVAGTALLIVLHVYHRFHWRLRVPSSSEPSLSGFKA
WPQEDPEGKRGIGVSSEKADSGSPLGVRITNKSTPGPKRVVGKQQWQKRTDHEGQRRDAA
STSWIKPLIFFTSLTGSTEKFARGLGEELRSAAQEQSKGSERGGILPPEIHDLSYIDFDE
YFIATPPPPPNTRHVYCFLIPTYNIDTIINTFLHHLNETHHDFRIDTAPLSSLAGYSVFG
FGDREGWPTEEEGFCSQARELDRWMAKLTGRKRAYPLGVGDVKSDAQAALKEWSGGLLDI
LDEIAVTGGLGEGVVGSGDPLETDDEADDDGDSADSKTNIRSRGKKDSQTVIDLEDIQAT
LDNESLSGRKGLAPLPVDFTTPGKSPVQSMPSDLKEMVPKTSPTYSALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WKVDPPEMIFQGAKEGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPRINE
FVSLLHGEGISSFLVCNAQHPEQLAALDRVTQLYVSIDASNRESLRRIDRPLHRDFWERF
QRCLDIMREKRLIQRTVFRLTLVKGFNVEDEAVGYADLVEKALPGFVEVKGVTYCGTSSS
AGAGLTMQNVPFYEEVAAFVVALGHELQRRGLKYGIAAEHAHSCCILIASERFLVNGRWH
TRIDYDRFFELLEKEKTDGIPFRPEDYTKETEPWALWGNGGFDPSDQRVYKKGRNKAPAM
KTDTLA
>A0A167HD56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium rileyi (strain RCEF 4871)|TrEMBL
MSAICEKIDPLQGIFGGRPRARLDGIIELWHDHRTPIIFCALIVLVVIRIFIHRIEETEP
LKALPKQFEQKIDPLTAAKKSSGVNSENTIAKSNGPRRIKGGITKKPSTGKEEQFDKSRP
IKVAVFFSSVTTKTERIAQQYLNALGKVADRLSCETPREFLKPELYDLTEIDFEDFFVSP
AKTAENAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLASLLGYSVFGFGDKE
GWPDETEGYCFQAKEMDRWMSKLTGRKRAYPIGMGDMKSDHVERFEEWALGIQEVIAYVA
SSGSLGDGVPGSGDAVESDAEDVAEEDDGEVLFEDDASGDNGESPRPLDDVEDLGRMIRT
SDGNGTPAKGKKAPLAVDFTSYGSSSTKKRTPTAPVIKEMVAKNSPTYAALTKQGYAIVG
SHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPH
INEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFW
ERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVCDFVKALEQRLKARGLKYGIAAEHAHSCCILLASERFLVDG
KWHTHIDYKRFFELLEERGPDGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIE
NVVVREAPPPESW
>A0A2E2CP83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPMEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEHTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRALAPLTDRKLLDDSPPSRVALV
GREIVPIPIPEATMQFPDDLGIAESIKHLKIVQ
>A0A3M1RG42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MMDEDIRRLLRSQGYHLVGSHSAVKGCHWLKESLVRGRECYKARFYGISSHRCLQMTPAV
AWCQHRCIFCWRPIEHTLGCEITGDVDEPAHIVEGAVEEQKRIVSGYWGHQWADKGKLKE
AFEPRHVAISLAGEPTTYPYIAELIERFKDRGMTTFLVTNGQNPERLAHVRPTQLYLSLI
AYDRDLYKRINAPQLPGGWERLNESLEVFRDNPSRKVIRITLVRGYNLERPELFAPFIER
AEPDFIEPKGYVHVGYSRRRLNRGDMPSLEEVLEFSRRLAAATGYSIRDHSPESKVALLE
KK
>A0A2D9M838|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPAIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSXTLNKVDSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDVCHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NQEIFNRLCKPKFDDHAWDKLEQTLELXPSLDTRTVCRHTLIKGESLGXVXDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDIMSFSNTLAPLVGREVLSDRRESRVALIGK
EMIPVTLPEKTRDFPADLGIAKPQNFKLPSF
>A0A2D7JVH3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKQVFDEVCRPKYNHGAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDEHIAQFSALDN
RADPDFIENKGYVFVGHSRENLSMENMPSHDDIMDFSNKIAPLTDRKVLSDSRPSRVALV
GRNITPIPIPEPTMFFPEDLGIAPSVKHLPIAS
>A0A2E7T0H1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>C7GN34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain JAY291)|TrEMBL
MDGFRVAGAIVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEVSGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFKKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A7K4B8D3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MPSEPCKPPEKILRGMGYQFFHPGSSAALKPCLWCKRSLTGGDQCYKNQFYGITSHKCVQ
MTPTLRCNHKCLFCWRSFEHEYSGEKDLLPEEIISRIPFLQKKALGGYKVSPRVTREKWE
EALSPNQYAISLSGEPTLYPHIVKLIDLLNQTGGTTFLVSNGTMPEVLKNCHPFQKYVSL
TGPDRETYLKMSRPDDDYWERILESIKSLGHETDNKKRTAIRVTLVKGMNDQDPAGYARI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHEEIEQFTKQMLPHLSYRIRGENSLSRVI
CLERDS
>A0A2R6ILZ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_4_69_31|TrEMBL
MSGSDGPKQVDDPNYHSVNHTAAQTCGWTKNALKGEGKCYKNIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPDAVAEASLELQRTVLSGFGGNDAVPRERFEEAM
EPRHVAISLDGEPTLYPYLPELIEAFHERDITTFLVSNGTKPDVLAECDPTQLYVSVDAA
DRWTFDETVKAVEDDAWERLVDTLDVLAEKDETRTVLRTTLVKGHNMHHPEWYATMFRRA
DPDFVELKAYMHVGHSRGRLDRDSMPDHDEVREFTEAVREYMPDHDVTKEVPVSHVTLLA
KTEDTWVPTLKKDSEFWERDPYARAGD
>A0A7L4JVX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ceuthmochares aereus|TrEMBL
TTSRNVCVFLVATYTDGQPTESATWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGNSVYV
DHYNTVGRNIDRWLWMLSASRIMTRGEGDCNVAQSRHGSIEADFEAWKAKFLNQLQALCR
GEKKSCSGKCKKGKCKSLGKHSKESSDHEHSASEHENTEAEELFETSSEEEADAEEAGGT
NSVVDVEDLGNVMNHMKKAKVLQSSMETVMLNNFVYQSMGFGYQLLQGKIHGLICFLFSG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEMILQEAIENHQNMIRRFKGVPGVKADRFEEAMTAKHCALSLVGEP
IMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDSSTKESLKRIDRPL
FKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEVKGVTYC
GESSASNLTMANVPWHEEVVHFVRELADLIPDYEIACEHEHSNCLLVAHKKFKINGEWCT
WINYDRFQELVQEYERSGGSKTFTAADYTARTPHWALFGSRERGFDPLHVRYQRKRKARD
VSGC
>A0A497I9Q5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanoarchaeota archaeon|TrEMBL
MKETTKFVYRKQGYYIIGNHSAVKLCHWLRMAMLGKGYCYKQKFYGIKSHRCLQMTPSLP
NCTHRCIFCWRAVELTENEPLTDGPQFIVEESIKAQRKLIVGYKGDPRVTEQIFEEAMNP
NQVAISLAGEPTMYPKLEEMIKEYHKHGFTTFVVTNGTFPDVIRKIRPTQLYISLIASNK
DMYNKVARPIGDTWDRFLESLELFPSVNTRRVIRMTMVKGWNMSNIDEYAKLIRKANPHF
VEVKAYMRVGYSRDRLPDSAMPSHDEILTFTKKLGEKIGYQLLDDKKESRVTLLSKEDYK
WRSLEKEQPTNYP
>A0A7K5W2H3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hylia prasina|TrEMBL
LDVSMDTWSYFHTCLLSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPSSPEG
TADKLGNGSAPHQAQEVHVAGVKIFYGSQTGTAKKFAKTLAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSLLQGLRYAMF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCRKGKCKSSGKQSKESSDHEHGTSEHENTEAEESFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLGRVWNAALSSCVSHSGYHLVYFVCQFLQAELNC
LMICALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKH
CALSLVGEPIMYPHINSFVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKE
SLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDF
IEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELAQLLPEYGIACEHEHSNCLLMAHSK
FQVDGEWRTWIDYSRFQELVREYERSGGSRTFTAAEYTARTPPWALFGARERGFDPSDVR
FQRKNKARDISGC
>A0A8J2RDQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daphnia galeata|TrEMBL
MKVAHPPLIGSFFLPTLGLAVFSLALGYWISRKKKSIVKDDEPNITQNSSSDTVGEIDSM
STLENVKGKKNKHQCNCGSTETSKFEKQPSQIKIMYGTLMGKSKKFAEILLEHIAEEGTQ
VSVVNLKECDSEDNFVGSDSKDTLFIFIVSTYAEGSPPDDAQLFYKWLEDSALDFRVPKT
FLADARFSVFGLGNSLYSENYNVIGRNIDKWLSQIGAERYAPLGLGDENVAESLHGNIEA
DFDHWCEGILNLLKYPQDTTAKKNGCSKGNDCCSKKGKKKSVNRLQKNKANRAEEKDVTY
DSDSDSDGNEAVVDLEDLGSFVRVENKVGVESEEEEEFVSTDGEPREMLTPQLRESLTKQ
GYRLIGTHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
SNPVGTEWRWKMDPAEFILEGALEQHAKMINQFKGVPGVQPQRLAEGMNPVHCALSLVGE
PIMYPEINRFLRMLHDKKISSFLVTNAQFPEAIRQLEPCTQLYVSVDASTKDSLKRIDRP
LFKDFWERFLDSLRALSAKGQRTVYRLTLVKAWNVEELESYAELVKLGEPDFIEIKGVTF
CGTSKASTLTMENIPWHHEVVTFGEKICSYLDSYGLAAEHEHSNCILLAKRSKFFKNGRW
NTWIDYDKFHQLMQDYYLSDGKATFTSEDYMAATPDWAMFGSPEHGFDPAENRWHRKPPK
KDISGC
>A0A835YFC3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Edaphochlamys debaryana|TrEMBL
MSWLGRLLTGRAPWGGGQAPAASGAGAETAPAAAPAEGGPSNAAGPDSAAAEAPSKQCCK
AKMEASGDVAAEGCACQTATAPAGAAPVIKVLYGSTGGTCRRLAAIVAEQLTAALPAAAT
SSVTAATPAGACGNGGCPTCTPPALDAVPAAAPAAAAATAVEAIGAPTVSVVDLASYEPE
ALLGEARDTLVVVVISTHEGGTPPQSAKFFCSWLEDASSDFRLGAAALNHVRFAVYGAGN
SLYGAQYNAVARRLEVQLLDMGARRAQSLGLGDEDTGDMAAHCAAWARQLAARLAGPRGA
QAQAQQGPGGEAAAEGEGQEEEEEEEEDDAFEEEDDDEEGGGSEVDIEDLGGAGPRRGKK
GAAAAGGAEGAAKAPGPGGKPEMLTPLVRGSLTKQGYKLIGSHSGVKMCRWTKSMLRGRG
GCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKTWKWAMDPPELIVENALEA
HRRMVREYSGVPGVKPEAVAEGLAVRHCALSLVGEPIMYPEINALVAGLHGRGISTFLVT
NAQFPDRMAQLSPVTQLYVSVDAATPESLKAVDRPLFADYWERFTACLSSLRERRQRTVY
RLTLVKGWNMKEVAAYAALLDLGRPDFVEIKGVTYCGSGGASSLTMANVPYHADVVAFGQ
AICEARGGEYGLACEHAHSCCLLLARTERFLVGGRWHTWIDYERFQQLVAEGRDFGSEDY
MLPTPPWAAFGSSEAGFDPGQQRVRKERRHPGRSGAASVARGDDEEQEGV
>A0A2R5LII0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ornithodoros turicata|TrEMBL
SVVEKAMTIFAALVILLTAHSSLGNDTEEVIGEGTTSWLSNTALTSLCGGIVTLLFLLVV
KDKFSKAQAHAYEKEAEKGRSVKVFYGTQTGNAQILAEKMFVELKASGYSVEVINLKRIE
PEECLLGEVKVKGLCLFIISTSAGGCPPDEAQWFCDWLKDTYADFRVQKSYLQGLDFAIY
GLGDSAYAENYNKVAKDVFFWLSKLGGRAVLPLCLNDESVDEGKYGTGRFAEWKEDVTSY
LRDGTLQTHKEKKVPDEVYETSSDEEKDVVDLEDLAGKSNGVEKKATQQKTQMITPVVRA
SLTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWKWDMDPPEMIVDAALNNHYKMIKEFRGVPGVQQVKLEEATRVRHCAL
SLVGEPIMYPEINALVRLLHERGISTFLVTNAQFPDAIAALEPVTQLYVSVDASSEETLK
KIDRPLFRDFWKRFRDSLSALSQKGQRTVYRLTLVKEWNMQELQGYASLVQLGKPDFIEI
KGVTYCGESKGSNLTMQNIPWHEEVVSFVEKLVALIPEYSLASEHEHSNCVLLAHRKFQN
DGKWHTWIDYDRFHELIERWRKSNGAESFTSEDYTFPTPAWAVYGARERGFDPKESRLLR
KSRKDIGGC
>K9ITW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desmodus rotundus|TrEMBL
PSLDSWDFSPLISLWIHRFYIYLGFAFGISLWICFQIAIRKQLFIFKNKNSQEKSVPKAT
RDLMTNGYISLQKKEVFVSGVKIFYGSQTGTAKKFATVLAEAVTSLDLPVAIINLKDYDP
DDHLVEEVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMKYAVFG
LGNSVYVGHFNKVGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGNIEADFRAWKTKFVA
QLQVLLKGEKKSCDGNCKKGKCESSQHGSEEVEPGSHPQDGVRQRDTEEEEPCESSSGAE
SGAEDHQSLTSVVDVEDLGKIMSHVKKEKREKEQQEEETGLFRSAVKNEASERRAMITPA
LREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPDVILKEAIENHQNMIKQFKGVPGVQEERFKEGMTVKH
CALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLTPVTQLYVSVDASTRD
SLKKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDF
IEVKGVTYCGESSASTLTMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLIAHKK
FKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPWALFGARERGFDPKDTR
YQRKNKSKDISGC
>A0A2V3J7L9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MRKTLEKQGYHFVGPHKHSAVKTCLWLWKAMRREGEGNCYKGKFYGIAAHRCVQMTPSIF
CNQRCVHCWRPLEAFNINEKKEEEVVWDSPEEIVDGCLKEQQRLISGFKGSHKTDKNTFA
EAQTPKHAAISLIGEPTLYPQLAELVQEFHSRGMTTFVVTNGTNPEVVRKISPSQLYLSL
NAPNEEIYKKVAHPDYNYWSRVKESLEELGRKGKEKEREEKEREEGEEAEEGEEEGKRRT
RTVVRITCVEGLNIQNPEGYVELLKIAKPDFVEVKAFMHIGYSRRRLPREAMPSHSRVKA
FASEIAEQLGSGSGADYKVVNESEVSRVVLVSKK
>A0A0N1I710|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptomonas seymouri|TrEMBL
MIALLYQIFVSLGLALIAFLLYERLAAKIGQPDDAKAPTTSADNVEPKAHSDDAAVFDRQ
VQAELRKLQGSKQMSADVVGTSPTPALANSSTNAKPATEAKLMHVDAAAAAPTAALRGAV
KDVKAPAEILIAYASQSQNSLALAHKLFSVLSAHLHAMHDSNVDSTAVCPQVRVLEMREE
EDVHSANRNGSALKGEAPSRPTAANVCRVDTILEPNHYALTVFVASTYTDGLAPPRSQAF
EAMLKDAFEDHRVPRNTLSKKRFSVFGLGDAAYGEQHFNAFAKHLHEWCRGLGAPAFVVP
PVYATENNAQSLFRIFSTALLKWVSRASFHADGTVTVKRKTDAASSTIEGSVAARARNRK
KATAAAGSSKSVCSCHAESGSGAEDDAAAAGGCCQGSAVHEAGQQAAYDAEEEEEDASSS
ARDDEADDMDDVEDLMWDGTDDAAFDTTKDHAELPELLYPKLRQNLEKQGYRLVGSHSGV
KLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACANKCVFCWRHHTNPISRHFRWK
QDPPELLIAQGMAAHYQMIKQMRGVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFC
DLLHEHHISSFMVTNAQFPEQLRDLKPVVQLYLSIDAPTPDELKRIDRPLFEDYWERCLS
CVRELAKKQQRTVFRLTLVNLYNTENVRAYADLVEMGQPDFIEVKGVTYCGTSTSSTLTM
KANVPRHDEVIAFCKALCEEMARRNPHYKTPQMHTTPKPKQKHDYIMEEDEDAEDEEEDV
IVIPPVERDRPYHIACEHEHSCCVLIALDKFFFGHRWHTWINYERFYELVESGRTDFTSL
DYAAVTPTWATYKSKEKGFDPEQTRVAGKKARPTATAPVSALV
>A0A368TEL6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MDEEAVVWDTPAEIVEGCMKEQRRLISGFKGSSKTSKAAFAEAKEPKHAAISLIGEPTIY
PHLQELIQEFHSHGMTTFVVTNGTNPAVLREIHPSQLYISLNAPDEAIYKRVAHADYWAQ
IQESLEVMKMMKERTVIRITAMAGTNMVDPGGYAKLLETANPDFVEVKAYMHIGYSRKRL
TRDVMPAHTEVKDFAGDITEHLTAAGGNYKIVDESEISRVVLISNLSSEVKALPKL
>A0A2R6XL54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marchantia polymorpha|TrEMBL
MSRQSTVLVVASCASVLVVSVSVFIYMRNKKTRAEADRELKNLLNKERRPQTEEEDLEEA
EDEEGEDEDEDDEDDDDDGDLEEPEGIGLDSKEQSSKVGGCCKTSRDSEKRSNGSGCCKA
KGTASSCGSKEQNGLAGDTQGNFIDDDVAFLYPAADEETPGATGNTECGNGCASHTTSNE
SSAEVCGKLLFVSETGTSQKLAENLGNQLLGRGVAVKVVDARSYEPEDLAKESLVIIVAS
TWSEGKAPKNGSYLLQWLDESSEDFRVGSGLLQNCKVAIFGVGSSVYGENFNVVAKAFES
HLTALGAHLILASGVGDDDLGDVEEQFETWSQSLVDHIRGTGAGSVLESSTENVPVSKEN
ETLMEEMVEEIYYTDTDEEDKENTDTLVDLEDMAGALGSTVKTKDPKKKGFVRKGKKNVQ
GGQAKKVEKYFQTPNGDDRKEMVTPVLRASLEKQGYKILGSHSGVKLCRWTKSQLRGRGG
CYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWRWKMDDPVEIVNAALDQH
TSMIKQMKGVPGVKPERLLEGMTPRHCALSLVGEPIMYPEINTLVDELHKRRISSFLVTN
AQFPDRITQLSPVTQLYVSVDAATKEKLKAIDRPLFSDFWERFTDSLTALRDKRQRTVYR
LTLVKGWNVAELDAYVQLLQLGQPDFIEIKGVTYCGSTATSSLTMENVPWHQDVKDFAEA
MVAATNGEYELSCEHVHSCCVLLAKVSKFKKDGNWYTWIDYEKFHDLVASGEPFSSEDYM
MQTPSWAVYGAEEGGFDPKEVRVKKERRHGASADPGGCT
>A0A2G9P6U3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon CG10_big_fil_rev_8_21_14_0_10_31_34|TrEMBL
MLTKEAKAELEKQQYRIIGSHSAVKICGWTKNMLRGKGSCYKHKFYGIKSNQCMQMTTSL
SCANRCTFCWRGYKAPVSKKWKWKVDDPEFILNGSLEQQKKLLSGFKGFKDVKMDLWNES
NEVRHVALSLSGEPIVYPKINELIDLMHSKKISTFLVTNAQYPEEIKKLKNVSQLYISLD
APNKKLLKEIDLPLFSDYWERLNKSLKEMKKKKFRTAIRITAIKGINMVEPENYAKLIKK
ADPDFVEVKSYMFVGESRKRLKEENMPSHSEVKEFTEKINEFLPEYEYCSEQKSSRVVLL
AKKEFKKKGKWVAWIDFDKFFKLVSKKKKFESKDYLTQTKK
>A0A2K5X1Z1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca fascicularis|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A4P8WFH3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema versiforme|TrEMBL
MSDSANPGADGASADTGDDAESDGGGPAQVSSPDYHSENHTAAQTCGWTANAMRGEGKCY
KNIFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVAWDDPEAVVDASIKLQKK
LLSGFGGNEEVPRDVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGT
RPEMLRDCDPTQLYVSVDAPERHTFDQVVGAMEDDAWANLLETMDVLAEKDETRTVLRTT
LVKGENMHSPDWYAGFYQQADPDYIELKAYMHVGHSQGRLDRSAMPDHEEVVEFAEDVGE
YMPEFDEVKGVPASRVALLSKTKDTWVPKLQKGSEFWERDPVTGD
>D7E5R6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303)|TrEMBL
MPDQIYNNIPDFRTLLKNQGYSLVGNHSAVKTCLWLKRSIKDEGACYKSRFYGIKSHCCI
QMTPTLLCNQKCIHCWRPTEIEVPAPEEWDSPVEIMGSSIYAQRKLISGFGGSAPRERWM
EANKPEHAAISLSGEPTLYPYLPELIDEFTKEGITTFVVTNGTRPEMITRIRPTQLYLSL
DAPDKNTYLEVCNPESPELWENIKKSLSNLYSKDVRTVVRITLIKGVNMYNPEGFAELIN
TAKPDFVEIKAYMHLGFSRGRLSRESMPSHDEVYAFASKIADYLDYEVADNVEISRVVLL
SRPLEPLPGQS
>A0A7G3ZJE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Torulaspora globosa|TrEMBL
MHFNRAGALVALLCVAIYWFLGGRSSIALAGTVFCGIAYKEAIDSGKNSSSEANSSEAAA
PKKKKGCCGGKGGKNCCSSKGGEKKSGCCCSSKKIESKDKQDFMMIPGSEASKEVNFPDE
IDFTNAFKPSGKNNGASAKPRKIISKPKLISKPKNEDGLVKSAMTISKDALLSSQIYIFY
SSLQGAAQRAASTVHETLSKIEGLDLEPILLNLDELDDIDEYFVSVPSENALYFLVLPSY
DTDCPLDYFLQTLEENFNDFRIDKFPLRKLVGYGILGIGDSESWPEKFCYQAKMADHWIA
RLGGRRVFPVGEVCMKRGGISDVQNWANLLSETLKDDEPILYEYDETIDENLQDGDDQLG
DLEDIGKESNGDESQIKQMVAENSPTYRKLTKQGYVIVGSHSGVKICRWTKSDLRGTGSC
YKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDPPEYILENALKGHY
SKIKQMRGVPGVVMERFAKAFQVRHCALSLVGEPIMYPYINRFVELLHEKGISSFLVCNA
QHPDALESIGKVTQLYVSIDASTKQELKRVDRPLYKDFWERMLSCLDILRTKQSHQRTVF
RLTLVKGFNMADISSYADLVQRGLPSFIEVKGATFAGSSDGNGNPLTMQNIPFYEECTNF
VKQFAAELQRRNLGYDIAAEHAHSNCILIASTKFKINDEWYTHIDFDKFFELLRSGENFN
PMDYIAKTPEWALFGNGGFAPGDTRVYRKGKKKSKNVPKAEPTT
>A0A5N6XKD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus sergii|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILVRAYRKFQPKSKAVTASSIPPSPRSQTPE
KCEQIRTGESEKPVAVEKSVPKPATANDPAPKAVSGPKRVSGRKPLKVAGRRREDQGPPL
SFIQPIIFYASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
DILIDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAALSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKGLQAATE
>A0A8C5NIX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Junco hyemalis|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRLYIYSAVALGISLWIVIHFTTTRQSHGSPSAPEGTSDK
LGNGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEIINMEDYDPEDG
LVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGN
SAYVDHFNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTRLR
ALCRGEKKPCRGKCKKGKCKTPGKQSKESSDREHGTSEQDDTEGEEMFETPSEEEAGDTN
SVIDVEDLGNIMGHMKKAKREQELQEGAAGAERREMITPALREALTKQGYKLIGSHSGVK
LCRWTKVCSVSFSHFINKNKWVTVPSSLRHHTNPVGTEWRWRMDQPEQILQEALEKHQSM
VRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINQLVRLLHQQGISTFLVTNAQF
PEEIRKLEPVTQLYVSVDASTKESLKRIDRPLFKDFWERFLDSLKALAEKQQRTVYRLTL
VKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANVPWHEEVLSFVQELAR
LLPDYGIACEHEHSNCLLLAHCKVSLPGHSCALLPAACCSSYPSTAVWAGKESKQTDCRN
LLEAEFN
>W6YAW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bipolaris zeicola 26-R-13|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLPILLSALVVATIARLIIYSRDRREKLPKSPVPQSPIE
KQKVELKPEWLPEYTTTLTSPDLNVDNHAEDDTSAVVAATKVKKGPKMVKGRKIPKKSVA
PTLTFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTGCDQASSFLKPQTHDISYI
EHDDYFITPPKADPNVKYFYIILIPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGDAEKRLEEWRIG
VQDALVELAEGRGLGEGVPGSGDPAESDEEDVDDAEEGNGQSSRVDDVEDLGSMVNSSSS
PIPIDFTTYKKSAPKLKSAPAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPEMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLDIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELNSRGLQYGIGAEHAHSCCVLLADRTRFMRDGRWATRIDFERFFDL
NEGKVQGTRVDDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKAEAEKS
EGQAEQTKKVALEF
>A0A1E4TB72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tortispora caseinolytica NRRL Y-17796|TrEMBL
NSNIVIFYSSISGTTERLAQSAKSILDQSLPTPATLLNIDYLEDQDSYFVSPPSSDTVYL
LLLPSYITESSIDFFLESLKETYNDFRIHSRPLNRISGYAVFGIGDAEFYADKFCYQAFA
ADKIIGKLGGKRMYPVTTYDVKSDVTSQNPIPAALTSWCSCIVSALKDPTPPEEIDAKDS
DDEDDSNAVADLEDLGSVMRSSNARIQDLPKEMVASGSPTYTALTKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLSCSSKCVFCWRHGTNPVGTTWRWQID
QPQDILKGAMEGHYKKIKQMRGVPGVNADRFQEAFTIKHCALSLVGEPIFYPHINEFVAL
LHARRISSFLVCNAQHPDELERMNRVTQLYVSIDAPDQTSLQKVDRPLHRDFWPRFQRCL
DIIRNKTSQRTVFRLTLVKGFNATDTKGYADLIEKARPCFIEVKGVTYCGTSKSNPLTMA
NVPFYEEVRDFVLELNNELERRKLPYGIAAEHAHSCCILMAQNRFYINEVWHTHIDYQKF
FDLLESGAEFGPMDYVSATPDWAHFGSDQAGFNPEDVRFERK
>A0A347AE36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. BRmetb2|TrEMBL
MILSEEKLEKLEKMGYRFVGDNRHAAAKVCHWTKKSILDEGVCYKEKFYGIESHRCLQMS
PSIPFCQQKCMFCWRDQSVTDTTWIGEYDEPKEILDGCITAQRNLLCGFFGNENANPKKI
QEAQDPTNAAISLAGEPVIYPEIDELISEFKKRKFTTFLVSNGLMPSKLENLENQPTQLY
ISVDAPNKKIYNNLCRPQIENGWEKLNKSLELLKTFDSRTVIRMTCVKGHNMQETQEYAN
IIKNSNPDFVEIKAYMYVGYSRKRLELENMPSFMEVKDFSAKISQECGYEVINDSEDSRV
VLLSRE
>A0A151E941|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon SG8-52-4|TrEMBL
MNTEFQKILEKQHYGVVGHHSGVKLCHWMRQSLLFKRECYKQTFYGIKSHRCLQMTPSIN
QCNQTCLFCWRHQGFTEKEFNDIDDPKYILDKSIEIQRKLITGFKGDERCDQKKWEEANN
PNMIACSLSGEPTLYPKLGEFFEECHKRKIITFLVTNGTNPKSLENLDPMPKQLYVSIVA
PNKDIYKKICSPLVSDGWEKINQTLDLLPSLNTRTVVRHTLVDGWNMDEKYISQYAYLDE
KASPLFIEPKGYVFVGYSRKRMNLSNMPSHKSVYDFGYVLAKYLGYELVMEKKDSRVVLL
SKTSKMERFDK
>A0A8C7YDW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias sinensis|TrEMBL
PAAPQTGSSLSENYLALLWHHRLYLYAAAALVVGLWVSLKVALNLRYKILGMFNFSLRLC
FQKSGEKDAVSGAIKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKALGFPAEVIDM
KDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYGRTYLKGLR
YAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQADFQAWK
GKFLSRLQALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEVRRREEDESDLTGEK
RSVVDLEDLGNLMKNAKKAKVRIQSAESLCFVRVLFTSSSLSFFPGYKLIGSHSGVKLCR
WTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPA
EKILQDALEKHQDMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLH
SRRISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTKESLKKIDRPLFKDFWPRFLDSLKA
LGEKRQRTVYRLTLVKAWNVEEMQAYAELIALGQPDFIEVKGVTYCGESSASTLTMANVP
WHQEVVAFVQQLAAMLPEYEVACEHEHSNCLLIAHKKFKLDGDWWTWIDYERFQDLVQAQ
QDSGGRQTFSALDYMARTPSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A842YLT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter thermautotrophicus|TrEMBL
MYLEESQRRRMERMGYRFVGEHRHSAVKTCLWTKKSIVNEGACYKEKFYGIRSHRCLQMS
PSVPFCQQKCLFCWRDLSSTGKTWDGPHDEPADIIEGAIEAQRKLLCGYLGNERADKIKV
MESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLSEEPTQLY
ISLDAPERDTYEEICRPQVPGAWDLLKGSLELMPSFNCRKVIRITAVRNINMKDPEGFAR
MIEAARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDGSRESRV
VLLA
>A0A091KUP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colius striatus|TrEMBL
LDVSMDTWNFFYTCLVSFWLHRFYIYSAVAFGISIWIVMQFTTIKLKKKVTEHGNPAASE
RVKDKLVNGCATLQAKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVTSLNLPVEAISMGDY
DPDDCLSEETTSRNVCVFLVATYTDGQPPESAAWFCKWLEEAASDFRFGKTYLRGLRYAV
FGLGNSVYVDQYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKF
LSRLQALCRGEKKPCSEKCKKEKCKSLGKQSKESSDHEHKASEYKKTEAEELFETSSEEE
ADAEEHGGTNSVVDVEDLGNIMSHMKKAKRERELEEGDAGMSLTGENSGRKEESEKREMI
TPALREALTKQGYRLIGGHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEALA
VKHCALSLVGEPIMYPDINRFVKLLHQHSISSFLVTNAQFPDEIRNLVPVTQLYVSVDAS
TKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGK
PDFIEVK
>A0A7D5I3G1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus zinderi|TrEMBL
MSRRRQKVREITDFKSLLKKQGYSLAGKHSAVKTCLWLGRAIKGEGECYKSHFYGIQSHR
CLQMTPTLMCNQKCLHCWRPTEIDVPMPDGWDSPVEIVGSCIDSQRKLISGFGGSAPREL
WMEGNEPGHVAISLSGEPTLFPHLPELIEEFKSKGLTTFVVSNGTVPAMMEKINPSQLYM
SLDAPDRQTYEKVCVPNSPGLWERINESLDILRNKDTRTVIRITLIKGVNMFNPEAYAEL
ISKADPDYIEVKAYMHLGFSRKRLPREAMPSHEEVLEFSAEVAEYLGYQVADDVEISRVV
LLSKDGSVSHLI
>G8BYX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5)|TrEMBL
MVVTNPITSTVVLSCVSLYYYFGGKLTVSVSLLVIYALAYDSEHENFLSENSQEVKSLEP
EKETKKKKKCCGGKDGGCCSTKNKNGAKKKEGCCGSGKCAPKNKNKSSGARSGDSEVTEK
ENEKEAKKSEFPMAVDFTQSFKIKGKSNSSELSELKVNGNNARPLKRFAKRIQNKKNDDN
VEVDIIKSAMTISKDKLLNSQIYIFYSSLQGAAARNAEKAHVLLSESKELESKPILMNLD
EIDDLDEYFVNTPVENALYIFVLPSYDSDCPLDYFLQTLSENFHDFRIDKFPLRKLVGYT
VLGLGDSESWPEKFCYQAKMTDTWISKLGGRRIFPVGEVCVKVDGEDKVTEWIDLFCEML
KDDEPILYEYDENDDDYEDPEETNENDDDELIDLEDIGAVNNDSSLGIKKMVAKDSPTYK
QLTKQGYTIVGSHSGVKICRWTKSDLRGTGSCYKQSLFNIVSSRCMELTPSLACSSKCVF
CWRHGTNPVSKSWRWEVDEPEYILENALQGHYSKIKQMRGVPGVVAERFAKAFKVAHCAL
SLVGEPIMYPYINRFVELLHSKDISSFLVCNAQHPDALRNLGKVTQLYVSIDAPTKFDLK
KVDRPLFKDFWERMLECLDLINSLQSHQRTVYRLTLVKGFNMGDISAYADLVERGNPCFI
EVKGATFAGSSTGNGNSLTMQNIPFYEECTNFVKEFSAELQRRGLAYDVAAEHAHSNTIL
IANTKFKINNEWHTHIDFEKFFTLLKSGEEFTHLDYMAKTPEWALFGNGGFAPGNTRIHR
KGKKKNKDLINETVTLPPLPAAI
>A0A3B4WU59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Seriola lalandi dorsalis|TrEMBL
MLNFFLVILLFLRHVSTSDTKVSQNEHRPSESYFMSIWHNRLYLYSAAALVFGIWFSLKM
ALKKKSFSKDIGPWVYKAVKNNDSSDRDTAVHVSGVKIFYGSQTGTAKAFAKELSEEVKN
LGIPAEVTDMKDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRVMTRGEGDCNVVKSRNG
SIQADFQAWKVKFLNRLQALAKGEKKSCSGNCKTGGSCKNKRKDGHMEEEEEEEKAAPQN
PSPEDALIESSSDEDESGLQDEKKSGSVVDMEDLGNIMNSAKKAKSKEEGRGDGQTVKLS
KLNGVKKIGDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIR
QFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSQQISSFLVTNAQFPQ
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVK
AWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADML
PQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQRSFSALDYMA
RTPSWALFGACEQGFDPADTRFQRRNKTKDISGC
>A0A7C0ZYI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MIRTKAELRGSDPILRIMNRLERQKYHHIGTHSAVKKCLWVHNALIYGRYCYKCKFYGIE
SHRCIQFTPSTLWCWNACLHCWRVRPQDLGLTYNDLTRLPYVDDPDILAEMAITEHRRTV
SGYKDRAPRKLWEEAMDPKHVAISLTGEPTLYPRFGELLEAFHRRGITTFVVTRGIRPEI
LSSLSIEPTQLYVSIESWNKNMYEYFNRPLTSRGWEKTLETLSLLQTFSSPTVIRITLVK
GFNMTPKDVKGFAKLLKNAEPTYIEAKAYMHVGGSTERLSRMNMPTLDEVTEFSKSLAEE
LGYSVVSYSAPSRVVLLCKLKDSVIRYGKGCPEGWKGGDEVAEALGEYSLPPSESV
>A0A662GBC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MIALSEKQVSVLRRKHYGVVGRHSAVQICRWTKKSILGEGTCYKERFYGVHAHKCAQFSP
LALWCNMNCVYCWRPMEWMRNYNIGYDEVEDPDTIVRGVIEERKRLLIGFLGNPKASKER
VMDALTPDHYAISLSGEPTMYPRLAEMIRLIRDRYKARTVFLVTNGQVPEALSRLYEERS
LPTQLYISVSASNREMCVRIQRPVLKDFWERLLKSLEIMREIEGSTRRVIRLTVIKGYNM
DERFMPEFARLIELANPDFVEVKAYMHLGLSTRRLSRDNMPRHEEVRAYSERLVNEYLRG
FRIEDEQPESRIVLLRNEGSTVPTRIYPS
>A0A224XL49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panstrongylus lignarius|TrEMBL
QALCEQLPEIPAIKINIFEMAKVEAEEVLLRDANAPDIISLIVMPTVDGGKSPDSGSWFC
KWLHEAATDFRIDKELYKGLHYAVFGLGNSAYGENFNIVAKKFDSDLKKLGAKRILPLTL
GNEDASNSISGSLEADFKSWFQELKELIKQSEISSSWLTQKVSNEDSSDGEENDKDDVVD
VEDLVRTTNKKESLKEKEMITPSLRQTLTKQGYKLVGTHSGVKLCRWTKSMLRGRGGCYK
HTFYGIQSHRCMETTPSLACANKCVFCWRHHSNPVGTEWKWKTDKAEDIVNDALRNHYNM
IKEFKGVPGVLFPRFEEGLIAKHCALSLVGEPIMYPEINRLIRLLHERQISTFLVTNAQF
PEAIANLDPVTQLYVSVDASTEESLKKIDRPLFKDFWKRFLDSLKELSKKGQRTVYRLTL
VKAWNFDEMQNYANLVNLGNPDFIEVKGVTYCGGDNTGPNKLTMANVPWHEEVVSFVQQL
TSLLPNYEIASEHEHSNCLLIAHKKFYIGGQWHTWIDYDRFHVLMQSYCKTEGDQNFTTL
DYTSPTPSWAVFGAKERGFDPIEKRWFRKSKKDISGC
>A0A166D500|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter cuticularis|TrEMBL
MSLNLEEQKKLEYSGYRFVGKNGHAGTKICHWTKKSLLNQGVCYKEKFYGIESHRCLQMS
PAIPFCHQKCSFCWRDLSLTRTEWEGDYDDVKTIIDGAIEAQNNLLCGFFGNDNADTKKL
LESKEPNNAAISLAGEPMLYPDIDELLAEFQRRNFTTFLVSNGLMHEKLKNLENEPTQLY
ISLDAPNNKVYKDLCNPQINDPWEKINKSLEALSTFNSRTCIRTTCVKGKNMKNHEEYGK
LINKANPDYVEIKAYMCVGYSRERLTLDNMPTFHEIHDFAEKIAKEINKEIINDSEISRV
VLLK
>A0A834ZLL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetracentron sinense|TrEMBL
MTMKSPSSLPARLTILALLSASTVYCFWKSRRLREQRLSSRNPKPNPSPSSSRGKLFFVS
QTGTSKTLARRLFDLLNLNHLPFDLVDPKDYEPEDLPKETLVLIVASTWEDGKPPPDAGF
FANWLLESSDDFRVGSLLLSACKFAVFGVGSRSYGETFNAVARDFSKRMRALGALEVLPV
CEGDVDLGDLDEIFDVWNRKLIAVLKGNSWENGRLSGSRIVSESESESVDGSEEDDVEEN
GLESGIVDLEDIAGKGPSRKSMTVSATNGKVNGEKEMVTPVIRTSLEKQGYKIIGSHSGV
KLCRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWTWK
MDDPIEIVNTAIDLHTKMIKEMKGVPGVKPERLSEGLSPRHCALSLVGEPIMYPEINTLV
DELHRRRISTFLVTNAQFPEKITMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFVD
SLKALQEKEQRTVYRLTLVKGWNTEDIDAYSNLFNIGKPDFVEIKGVTYCGSTATSKLTM
ENVPWHSDVKAFSEALALKSKGEYQVACEHVHSCCVLLAKAEKFKVNGQWFTWIDYEKFH
DLVASGKPFNSNDYMAPTPSWAAYGAEEGGFDPDQSRYRKERHHKGIR
>A0A444S8W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium dahliae|TrEMBL
MSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQVTGEKPEQLKALPKKL
AADETVAEKAALARDAKAEKPPVVVVAEASGAPRAPKTTSGPRRVKGGVVRRRSSDDNVD
QPPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHKAAPETRCTFEAPELLDLAEVDFDD
YFVTPPPAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSVFG
FGDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIIEI
LGQLARTGGLGEGMPGSGAPVESDEEDADEEDDDETLVEDGEAKPEKLKNSKNLEDVEDL
GRIMKDSRPDSVPAKGKGAPIAVDFTTYGKTAAKKAAPAPPTVKEMVPKNSPTYASLTKQ
GYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGE
PIFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRP
LHRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDDEVDGYAALVERGLPCFIEVKG
VTYCGTSTASNAGLSMSNVPWYWEVCDFVKKLEARLADKGLRYGIAAEHAHSCCILLASD
RFRVDGKWHTTIDYQRFFELLEERGPDGDWRAEDYMGPATPEWATWGNGGFDPRDDRVDR
KGRKIEAK
>A0A8H4MS78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neosartorya fumigata|TrEMBL
MAEHSTAEGLLVFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSRESSNKATAQKAEQQPALANGSAKPTSGPKRVTGKKPSKVAGRRGQTEDAEPL
AFIQPIIFYASLTGNTERYAKVLLDELRVAAQKRADLRDRERGLLPPQIYDLSYVDLDDY
FTSAPKPPPTSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAETSLKEWSLGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDLLHGEHISSFLVC
NAQHPDQLHALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYADLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEREK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A5E4JPT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MQFAISLTGEPTLYPKLGELIKELRDMKKTTFVVTNGLQASVLKKLNLRKQLPTQLYLSL
NSPNKKMYENWHRSSEKNAWKKFNETLVLFPKLKTRKVIRMTLVKNLNDQDEFIKEYAGL
IKKAKPDFIEVKSYMAIGFSRQRLGYELMLSHQEIKNYSKKLAKELGKDYSILADHKLSR
VVLIGKNKKSMKIQKNEI
>A0A7D5P2S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halosimplex rubrum|TrEMBL
MSESDGPKQVSDPEYHSENHTAAQTCGWTANSLRGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPSAVADASLKLQKKILSGFGGNEEVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFRDRDITTFLVSNGTKPEVLAECDPTQLYVSVDAP
DRWTFDETVKAVEDDAWERLIDTLDVLAEKDETRTVLRTTLVNGNNMHHPEWYASMFQRA
DPDFVELKAYMHVGHSRGRLDRDAMPDHEDVRGFTEDVMEHMPEHDYLNDVPVSHVTLLS
KTEDTWVPKLQKDSEFWERDPYAEASD
>A0A2J6RC34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyaloscypha variabilis F|TrEMBL
MAEETWMFGPWLPFELADIVAVWHEYRIPILLSTFTALMIFRTVLHLRSPREKLLYTPPI
LPPLPAEKESLLYDKRVSEEKVPRRIVGGLKKKKSSEDTLQVGDRKIQVLVFFSSLTGTT
EKKAKAFLEGLAKSTKNLEDSTTTFPDPQLLDLSYIDYDDYFITPPKTDTETQFFYLLLL
PTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQARE
VDKWMAKLTGRKRAFPLGMGDSKTNAMQRLEEWKEGVEDVLGHIASTGGLGEGVVGSGDA
VESDVEDLDEEDEVLFEEQKVAQRKTKIQKKDVLNDLEDIGSTLNKPMVDPSEPLEVDFT
TYSKKARAAPTTIVKEMVPKNSPTYNALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYK
YSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIFAGVKAGHYQK
IKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHAEHISSFLVCNAQH
PDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLEILRERRFEQRTVFRL
TLVKGFNIEDEAEGYAALVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVCAFV
EALNVALEKRGLKYGIAAEHAHSCCILIASERFKKEGKWHTRIDYEKFFECLESGEKFTP
EDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTDSQGEVMGE
>A0A396JJV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Medicago truncatula|TrEMBL
MPFSSVPARLTLLALFSATTFYFFYKSRRLRNLKQLTLNSQNPNTNPKILFISQTNTSKT
LANHLHRFLTSNNLAFDIIDGRNYEPEDLPKETLLLIVASTWEDGKPPPEYKFFADWLAE
SSEDFRVGSLILSKCRFAVFGVGSGGYGDNFNAVGKEIVKRMKALGGNEMIPLGEGDVNG
GEVDEVFEKWCGKVVGMLKGVDDGGGDLENGEEESGALSSDEEESDEEEEAESEIVDLED
IAGKAPSRKLVATVKESNGRLNGKKEMVTPVIRANLVKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWVWEMDDPIEIVNS
AIDQHTNMIKQMKGVPGVTSERLTEGMTPRHCALSLVGEPIMYPEINTLVDELHKRRIST
FLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPLFGDFWERFIDSLTALKEKHQ
RTVYRLTLVKGWNAEEIDAYYKLFSIGEPDFIEIKGVTYCGSTATSKLTMENVPWHADVK
AFSEALSLKSQGEYEVACEHVHSCCILLAKTKKFKIDGQWYTWIDYDKFHDLVASGSTFD
SKDYMAATPSWAVYGAEEGGFDPGQLRYRKERHHKSNRKESG
>A0A7K8ZHK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Grallaria varia|TrEMBL
LDVSMDTWNYFHTCVVSIWLHRFYIYSAVALGISLWIVIQFTTTKTKQKGEKSNGNPTSS
KGTEAKLVNGCATPQAKEVYVAGVKIFYGSQTGTAKGFAKALAEAVTSLNLPVEVINMGD
YDPDDCLLEETTNRSICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLEGLRYA
VFGLGNSVYVDHYNTVGRRIDRWLWVLGASRVMTRAEGDCNVARSRHGSIEADFGAWKAK
FLSRLQALCRGEKKPCSGRCKKRKCKSPGKQSKENSDHEHGASEHENTEAEELFETSSEE
EADTGETGGTNSVIDVEDLGSIMGHMKKAKRERELEEGGVGMRENTGRKEEGEKREMITP
ALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVQATRFEEALVVK
HCALSLVGEPIMYPHINRFVKLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTR
ESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELRAYADLISLGRPD
FIEVKGVTYCGESSASSLTMANVPWHEEVVGFVQELAELLPDYEIACEHEHSNCLLMAHK
KFKVDGEWHTWIDYERFQELVREQEQSSGSRTFSAADYMARTPSWALFGARERGFDPLDV
RYQRRNKARDISGC
>A0A8C2ANL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKKKMVDAVSPLLDKSVKNQKHSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVI
AQGIQCEVMDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSQSHAEKNNS
EEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRG
VPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYE
IACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPI
WAIFGARERGFDPSDTRFQRKNKTKDISGCLEGS
>A0A7L1L171|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Himantopus himantopus|TrEMBL
LDVSMDAWNFYYTCLLSLWLHRFYIYSVVAFGISIWIVIQFFKTKKNVTASEGTEDKLVN
GYATLQAKEVYVAGVKIFYGSQTGTAKKFATGLAEAVISLNLPVEVINMADYDPDDCLPE
ETASRNVCVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYAVFGLGNSVY
VDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQALC
RGEKKPCSGKCKKGKCKSSRKQSKESSDHEHGASEYENAEAEELFETSSEEETDAEEAGG
TNSVVDVEDLGNIMSYMKKAKGYTNARIHVWALVSVLSLADPWLNCATVVTDALIYFLFS
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGE
PIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRP
LFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLITIGKPDFIEVKGVTY
CGESSASNLTMANVPWHEEVVRFVQELADLIPDYGIACEHEHSNCLLIAHKKFKVHGEWC
TWINYDRFQELVREHERSGGSKTFTAADYTAKTPRWALFGSRERGFDPSDVRYQRKNKAR
DISGC
>A0A8C1PZL6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKKKMVDAVSPLLDKSVKNQKHSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVI
AQGIQCEVMDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKKGSCKNKKKHKEEAEDSHSLEELMES
SSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYSLCSFRTHLTIRD
FRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWSWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVG
EPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVT
YCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEW
WTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKT
KDISGC
>A0A831JYT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera sp|TrEMBL
MTNRIAKQIQTTQLKYAYDTLRKQKYHLIGAHSAVKKCYWVHKALTEQKFCYKAKFYGIE
THRCIQFSPSVLWCWNYCLHCWRYRPADRTKWTETILPSADDPKFIVEMAIKEHRRTVSG
YKMYPSVSKKMYEEARNPKHVAISLTGEATLYTRIDDLIEEFHKRNMTTFLVTRGVRPEI
LANLRVEPTQLYVSIESYSPETYAYFNNPISSNLWSKTLQTLELLPSFTSPTVIRITLVR
SFNMNNEAVKQWASILKKAQPSFIEVKAYMHIGGSITRLSRDDMPTHSEVREWASKIAEA
VGYNIVSESKPSRVVLLSTLDKPVIRYGNPPISWYDPDPGDEFSGEYGAPEEAI
>A0A8B6YNH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Camelus ferus|TrEMBL
MDPSLNTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQDKKSQEKTVPKASQD
LMTTGCQSPPKKEIFVSGVKIFYGSQTGTAKKFATILAEAVTSLELPVAITDLKEYDPDD
HLVEEVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMKYAVFGLG
NSAYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVVKSKHGSIEADFRAWKAKFISRL
QALRKGEKKSCGGNCKKGKCESNQRGSEGTEPGPHPPDRVHQRDAEEEEPVGSTSEEESG
SEDHQSLNSVIDVEDLGKIMDHVKKEKREKEQQEGETSAFRSTAKSDASERRAMISPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFLKLLHECRISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVARFVCELVELIPDYEIACEHEHSNCLLIAHKKFK
IGREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYVARTPHWALFGANERGFDPKDTRYQ
RKNKSKDVSGC
>A0A7K8S9W2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhodinocichla rosea|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTTRTKRKVTEPSPSSPEG
TSDKLGNGCAPRQAQGIHVAGVKIFYGSQTGTAKRFAKSLAEAVFSLDLPVEIINMEDYD
PEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRKIDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFL
TRLQALCRGEKKPCRGKCKKGKCKSSGRQSKESSDREHGTSEQDNTEAEEFFETSSEEEA
GGTDSVIDVEDLGNIMGRMKEAKVLLLERVWNVHSVNHSGYHLVYFVCQFLQAKLSCLMI
CALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWHWRMDQPEEILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCAL
SLVGEPIMYPHINHLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQV
DGEWRTWIDYGRFQELVRERERSGGARTFTAAEYTARTPPWALFGAKERGFDPLDVRFQR
KNKARDTSGC
>A3LT99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)|TrEMBL
MGAGSGLLVVCGVVHAISGGRISLLSESPIYAVDFTSTSFTPSGTSVIPKREVRTTRAKR
TPKVFKKAMPVKSIVEPTMTKSEVKLLESQIYIFYTSLTGSSQRVATALKEKLEGLEDLQ
NEPKLMSLDDDVDDLEEYFLKTPDNGATKNIYLLVLPSYETDSPIDYFLEHLKDTYQDFR
VDKYPMRTLLGFAILGLGDSESWSGDKFCYQAKLADRWMGKLGGRRLFPVGEVCMKYEGE
PKAHEWIQNFASLMVDDEPFYIDEGEDDIDDSDKEDSEGNSDDADTLVDVEDMGNIIRKS
GTKGLSETETKEMVAKDSPTYKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFY
GIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWVLDPPEKVMEGALQGHYQKIKQ
MRGVPGIQMDRFQEAFQVKHCALSLVGEPIFYPHINEFVGMLHEKHISSFLVCNAQHPDN
LAKLSKVTQLYVSIDAPTKTDLRKVDRPLNSDFWERLMSCLDILRTVQSHQRTVFRLTLV
KGFNMNDIESYADMVERARPSQIEIKGATFCGSSTGNGNPLTMQNIPFYDECKEFVINLS
NELQSRGLNYDIAAEHAHSCCILMADTKFKINGKWHTHIDYPKFFELLESGKDFVDLDYV
RETPDWAVWGSDEAGFNPEDTKYDRKTEKLKKKLEREEQARKVIEQTE
>A0A218ZXA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon B_DKE|TrEMBL
MENKYASVYKKQHYGLVGKHSAVKVCHWTKKELSGEEGCYKGTFYGIRSHQCIQMTPALN
SCTENCTFCWRFQGFDSMHISDEDDPELILEESIKAHRKLISGFKGNSKVTKERWEEAEN
PKHIAISLTGEPTLYSRLGEFIALAKKRGMTTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKQIFNDVLNPALGNAWENFNRTLELLPSLNTRKVIRHTLVKDVNMPYIDEYAALDSKA
DPDFIECKGYVHVGQSITKLTIDNMPSHDSILEFSNALAGKTGYQFTADRRDSRVALISK
DPSMAKINFDEIFKSESKKMIAVA
>A0A7J8Z3G5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium laxum|TrEMBL
MTPSSFSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENDIVYESDVESLESDDDDDGEGGEDIVDLEDI
AGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTA
IDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTF
LVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQR
TVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVRA
FSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFAS
DDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>F9F9F2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum (strain Fo5176)|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8C5LGE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Jaculus jaculus|TrEMBL
VDPPLAVWDLSSSLLSLWMNRFYIYLGFALGITLWICVQIVMKKQGFARILAKAVTSLHL
PVAIIDLRDYDPDDHLVEEITSKNVCAFLVATYTDGRPTESAEWFCRWLEDAASDFRFGK
THLKGLRYAVFGLGNSAYSSHFNKVGTNVDKWLWMLGAHRVLTRGEGDCNVVQSKHGSIE
ADFRAWKTKFISQLQALCKGEKKKSCGGKCKKGKCESKPRGSGETQPASGAQGESHHREA
EEEEPCESTSEDDFGTDDHQSPSSVVDVEDLGDIMNHMRKEKRENDQDEKASVLRNTEKN
EDNKGRAMITPALREALTKQVDAPGARRLLQSHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEMILKEAIENHQNMINQFKGVPGVQSTRFEEGMQIKHCALSLVGEPIMYP
EINRLLKLLHQCGISSFLVTNAQFPVEIKNLIPVTQLYVSVDASTKDSLKKIDRPLFKDF
WQRFLDSLKALAAKQQRTVYRLTLVKSWNVDELQAYAELVSLGNPDFIEVKGVTYCGESA
ASSLTMANVPWHEEVVRFVRELVTLIPDYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDY
SGFQELMRQYEESGGSKTFSARDYMARTPQWALFGARERGFDPKDTRYQRKNKAKDISGC
>A0A1N7BVG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haladaptatus litoreus|TrEMBL
MSESDTVEETSTSNQNSKRSDDGPKQVDNPDYHNENHTATQTCGWTANALRGEGKCYKNI
WYGIESHRCIQMTPVVKCNERCVFCWRDHRGHSYELGDVEWDDPEAVVDASIRLQRKLLS
GFGGNDEVPREIFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTNPE
MLAECDPTQLYVSVDAADRATFDRVVRAVDDDAWENLIDTMDVLAEKEDTRTVLRTTLVG
GENVENPDWYGAFYERADPDFVELKAYMHVGHSRGRLDRDAMLDHEEVVEFSERVQEYMP
EHDVLKEVPASRVALLSKTKDTWVPKLKKDSEFWARDSVTGEWKKTN
>A0A1V4TNB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregula sp. PtaB.Bin085|TrEMBL
MPSKPCEPLQKQGYQFFSKTSTAALKPCMWCKRALQGGDMCYKHQFYGIASHRCVQMTPT
LRCNQRCLFCWRSFEHEPAEEEECPPETILTGIHRLQKKALAGYNAVLDNTVTDERWQEA
LDPKHVAISLSGEPTLYSRLPELIDLFNSRGYTTFLVSNGTNPGMLERCKPFQMYVSLDA
PDRETYYKVCRPLGDTWDDVQESLRLPGSQRSAIRITLVKGLNDFAPERYAAILQDSGAR
FVEIKGYMYLGYSRNRLARENMPEHAEVRAFAEKVAAACDYRYKDENELSRVVVLERIS
>A0A1B8CSA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. 24MN13|TrEMBL
MANNEYFGADIASHASENYFMALWHTYRIPLILTALALLLITRTVLHLKVGREKIVYTPP
PTPSEKAPLAANPQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLGDKPASKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLAPIAHVLAELEDDDEYFLGLPK
PEDDSQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSAVWGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAKERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEEAEDDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQDESEEQDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIALRAL
PRRRTDLLPLPQRIHRYAAQRAHLLLPRLHAQHPGQLATLKPVTQLYVSIDASNRESLRK
IDRPLHRDFWERFQRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFV
EVKGVTYCGTSSSGAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCIL
IASDRFKKEGKWHTRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVY
RKGKNK
>A0A662FJ40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MITPERKADLEKQQYRIVGNHSVVKVCSWTKQCLRGKGCCYKNTFYGIKSWRCIEMSPTI
LCDQRCLFCWRDTEHSSTTKWAGPIDDPKTIVDGCIKEWRELLYGFGGSETVDKEKYKEV
DKPLHFAISLTGEPTLYPRLPEMIKEIHNRGMTTFLVSNGTIPGMLNKLLEEEAEPTQLY
ISLVGANKEMFETVARPILKEAWEKLQESLAIMHKFKRSVIRMTMVKGLNMTQAEKYAEI
IKKAKPDFIEVKGYMHVGHSQKRLKQENMPTHAEIQEFARQIAELTGYHYTDEREESRVV
LLVKKDPEIKQKILE
>M0AFP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba chahannaoensis JCM 10990|TrEMBL
MSDSADAGVDVEVGADADTETDDGDRDGGPAQVSSPNYHSENHTAAQTCGWTANALRGEG
RCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDGVEWDDPEAVVDASIDL
QKRLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVS
NGTRPEVLRECDPTQLYVSVDAAERHTFDQVVKAVEDDAWDRLLETMDVLRAKEETRTVL
RTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVVEFAES
VAEYMPEFTECKGVPSSRVALLSKTSDTWVPKLKKGSEFWARDPITGD
>A0A843ELQ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MDENYRNLLIKQQYRIYKDHAAVKLCHWMKESLTHGRKCYKQDFYGIESHRCLQMTPAIN
ECSHRCQFCWRVQDRDFEVTDWADPVDMLDNLIEMQRSLITGFKGDPRVDRKMWEEANHP
NQVAISLAGEPITYPYLSDFLKECHKRKMMTFLVTNGTYPEQLEALDELPRQLYVTVAAP
NEEVYKKVCVPKISDGWQRLMRTLELLPSLDTRKVIRHTLVKNLNFGWVDEYAKLDEIAG
TDMIEPKGYVFVGSSRMRLTNDCMPSFDEIMDFSTQLGERVGMSVIKQKPDSRVVLLARD
GVETDVRRYYHLDD
>A0A1E3QCH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lipomyces starkeyi NRRL Y-11557|TrEMBL
MVVDLTNAALAPTELSSSDGSALAVSTTTTARKARGGKVFTRRSKNANTQPLPTKSDIYI
FYSTLTGTSEKYAAHLQATLSQHSQLSTRGIHTQNLDYLDDIDTYFVAPARFLENAVYLF
VVPSYVSESPLDFFTETLKDTYNDFRIDSRPLRNLGGYAVFGLGDREGWDGDMYCYQAME
VDKYLGKLGAPRAFPVGTGNVSGKANDEYEEWIKHLIDALTDPAGVGEMIDIGDSDDEGV
EAENEEIDIARPASLKLSKATGAKDVIDVEDMGVIIENSRASSDLTSRKEMVGKDTPTYN
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWQVDPPDLILKGALEAHYRKIKQMRGVPGVQAARFAEAFTVRHCAL
SLVGEPIFYPHINEFVGMLHERNISSFLVCNAQHPEQLKALDQVTQLYVSIDASDKESLR
RIDRPLHRDFWERFNQCLDILRIKTRQRTVFRLTLVKGFNASEVLGYAKLVAQALPCFIE
IKGVTYCGTSSATSGPNGAFKGASKDSLTMANVPFYEEVRDFVLQLDASLKDLGLDYDIA
AEHAHSCCILIAQKRFKIDGEWYTHINYNRFFELLRQGIEFGPMDYIAKSPSWALFGSEQ
AGFNPEDERVVSKKSKAYKSEQLAI
>C5FK09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)|TrEMBL
MVVPFEVTLSIWHTYRTYILALLLTVSIIVAKISSHGRQLGSGSIPEKQGTSKKAPDDTA
PLGRVESTTPTNNTPLKSQTKTVPKRLRGMKPSKGDTKATAQITAIQPIVFFTSLTGSTE
KRARTAFEHLKAKLEVAPQNAQCRLLPPELFDLSYIDFDDYFVTAPKPLTSGPGTSFLYC
IILPSYDIDSIINNFLGHLDETHNDFRIDTSPLSGLTGYAVFGFGDKEGWPTLEEGFCSQ
AVAVDKWMAKLTGKRRAYPLGLGDVKTDGEQALQQWCDGIVGVLHDISENGGGLGEGVPG
SGDPIESDEDDVEDDGIFQNPSRPRRSKAKVSKVTDLEDIKFKPEDLLDDEPIDFTTYST
TKSSPSPSKEMVPSTSPTYTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGI
KSHLCMESTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLRG
VPGVKAERFAEAMRIRHCALSLVGEPIFYPHINELLSLLHSEHISSFLVCNAQHPDELAA
LQRVTQLYVSIDASNRESLRKIDRPLHRDFWERLQRCLGILREKRKVHRTVYRLTLVKGF
NIEDEVEGYADLVEKGLPCFIEVKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNEE
LARRGLAYGISAEHAHSCCILLASNRFLVNGKWHTRINYERFFELLEHEKRTGDSFTPED
YMRETEEWALWGNGGFDPSDQRVHTKGKNKGKIGVPPPSGKDLAAIS
>A0A1C6YJA1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium chabaudi adami|TrEMBL
MVTKREDELVLPPNEGGNINTYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIYFFNN
ILNHFNTISTITKGDNKNNTIFEGSISNEINNIEDYMLEYFRSKLLKTNKKNKDGKFVKK
CKNEKTNNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCSIENNISEIHFDFVN
GNEFDSYTFFENSENNDLNILFMFISTYNFGAFPTNCYKLEDILTDLVNDFRVEKNYLKN
IFYSCVGFGNKEYGSKYFCTPIKKCDKLISSLGGNKLEKTLTLCSTMDNEEEFIHWKSSL
LKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSESINDEERQASKSVD
NNNIHKCDCIRNVVSSEHLDASKESGDNHNKLTNKINGHISFSTSKMDASTTEKCGCTSN
NCLNGNDKYINEKEVINNNFETSIVNGCCKNDYEQNDELINSDFSNESMNENNDEINCNS
SEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKAQIRGRGGCYKHTFY
GINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKEL
KGVHNIINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNEL
KKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKERKERTVFRFTLVKEY
NMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSK
RSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNFSAIDYCAET
PEWAVVGAPECGFNPSDQRVYTKGKNKNKNNINTMEVKT
>A0A830GUS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermocladium modestius|TrEMBL
MEVQEERLRYHEVIDGKLRIRIDTRADLLRSKYGVYGHATVELCHWSKSALSGGPSCYKY
KFYGAPVGGSHRCVEFGPVGMTCSNRCVYCWRPTDSFDTLSPREEEVMDPEELLNGVMAE
RRRLLSGYFGHPEGRKRIKEALEPTHFAISLSGEPTLYPKLAGLIRLIKSMPNTRSIFVV
TNGEHPEAVEKLAEENALPTQLYLSCNAPNKQLFNKINVPVMKGEGAWEAWLKTLDMLPK
LNTRTVVRITLIKGWNTEPEHIPEFAELMRRGSPHFIEVKSYMHLGHSIYRLSRDNMLSH
DEVKEWAMKLLKEVGDMYEYMDEDANSRIVVLQNRKRRVDRWIEKPASSPSYSQ
>A0A1C7NFG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Choanephora cucurbitarum|TrEMBL
MSDFINSLLYGFTNILSVGPEPPREEKEEGCSGSSGQGCCRDQPDQATGGCCQSTTTATA
TAETTNKQSDPVVDGCCGGNKEKSCACESSNEPVVIDNLKIIFSTLTGTAKVLATEMQQK
IEQNNRVTVGKLEVMDITEYDNDQLLQETAVCVFVLSTYNVEGPLDWFTNWLHDLRYDFR
VDRDALKKLRYAVCGLGDSAYGEEFNIAAANIDKWLGRLGATRIYPLGECDKNADQKGQF
DVWSNGFVSELQDKHSLEFSPTNIAFQSDDEDDEEADEEEQEAQVDIDGTGSGDEMVDLE
DMGNMASKIKAAKARRAEEEEEFENSKARPRRQIGNEDAPKKTAQPRAMVSPMIHKNLTK
QGYKVVGTHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSLACANKCVFCWRH
HTNPVGTTWRWQVDDPQFILDGAMENHYKMIKQLKGVPGVKAERFQEAFTIRHCALSLVG
EPIFYPHINEFVTKLHEKNISSFLVTNAQFPDKIADMVPVTQLYVSVDAATKESLKKIDR
PLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNTAEIDGYVELIRRGKPSFIEVKGVT
YCGYSGASDLTMANVPFHVEVIDFCRQLVAKLDGEYEISAEHAHSCSLLIAHKSFKVDGE
WYTHIDYPKFFELVKSGKPFNSLDYMAKTPDWALHGHEAAGFDPNETRHYRKNRKIVTPP
VIPAVGTA
>L9KFF6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tupaia chinensis|TrEMBL
MAAPKFSGSGHTAKDPLDTWDFSSPLTSLWINRFYIYLGFAFGISLWICVQIVIKKQNKN
SQEKSFSKATRHLMTNGSLSLQKKEIFVSGVKIFYGSQTGTAKGFAKVLAEAVASLNLPV
EIINLKEYDPDDHLLEEATSKSVCAFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTY
LKGMRYAVFGLGNSAYVSHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVRSKRGSIEAD
FRAWRTKFISRLRALCKGEKKSCGGNCKKGKCESNLHGSQQKDLASHTQDESHHRDPEEE
EPCESTSEEECGAEDHQSLNSVVDVEDLGKIMDHMRKEKREKEQQEEKRSLGKIEDDERR
AMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVPGVKAERFEE
GMKVKHCALSLVGEPIMYPEINKFLKLLHQCKISSFLVTNAQFPVEIRNLKPVTQLYVSV
DASTKDSLKKIDRPLFKDFWERFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVC
LGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVDLIPDYEIACEHEHSNCL
LIAHKKFKIDREWWTWIDYNRFQELVQEYENSGGSKTFSTKDYMAKTPHWALFGARERGF
DPKDKRYQRKNKSKDISGC
>A0A151LRA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium reichenowi|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINEIINKNIYMNNMNGNIHYDDILQKKDYIEKKIQINESYKNNDNVDDSNIDGNIIHK
NNCVNNWLDIKDMNSLENEIIEYFKLRFDKYQVNNKKRKEKISRSNYENMVPLYYNKNIN
YLEPYEENVKMFNSKFKNYIDCTIYNKNIGKIYFNLIDANNHDYYSFFDNTENYNLNVLF
FFISTSSYGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPI
KKCEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYCFNYMKRWYMN
KRIYDTLSYYCYFFSNYTNFNVNQTEEIKYYMHDQELESEKKKKKKKKKEKEKEKEKEKE
KGDLSIYPMEQLEGCHCNKPYQENDLSIDQNNINYNNNKCCNNEIYNTHNDIYDNVKDDH
QISLSNMGKDEKDFLNEHKTKVDKTNGMMNEKREEVYVRGDTQGVEGCTNCNCQSVNEYN
DTSNTNIMNNKNNMNNKNNMNNKNNVNNKNNMNNKNNVNNKNNVNNTNNMNNKNNVNNKN
NVNNKNNVNNKNNVNNPNNIMTGENSMSESETSSNQSYPDDEDEQIEVEDLISGEKKDML
SSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLAC
ANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIIMERFEKAMN
IKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPVELENLNTVTQLYLSIDAP
NKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEIDSYINLIQL
GYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINKKKALSHIYEISCEHKHS
CSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVETPHWAIYGSQESGFSPC
EKRVYTKGKYKNKNQQS
>D3S820|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus sp. (strain FS406-22)|TrEMBL
MIPEEIYKILRKQRYQIDNHTAVKLCGWVRKKMLEDKNCYKSKFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPRDIGINIKEIKEPEWEEPEVVYEKILAMHRRIIMGYAGVLDRVGEK
KFKEALEPKHVAISLSGEPTLYPYLDELIKIFHKNGFTTFVVSNGILTEVIEKIEPTQLY
ISLDAYDLDSYRRICGGKKEYWDSILNTLDILKEKKRTCIRTTLIRGCNDDILKFVELYE
RANVHFIELKSYMHVGYSQKRLKKEDMLQHDEILKLAKMLDENSSYKLIDDSEDSRVALL
QNENRKINPKIFEE
>A0A6A6C925|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zasmidium cellare ATCC 36951|TrEMBL
MDTSRLLELPDELLLIWHAHRTEILLSTGVLLAIVRLLVHWRGRKAKIALTPPIGTPTDE
KPRFETEITPEKAVVQDVSIGESPLQKRRTPRRVKGTRNLRKSEAEMPVVERIQPYVFYF
SLGGSTRAQAEKLTASSVDENEAMLPPHLLDLTEIDYEDYFISPPKQPASGTASFYSILI
PSYNIDTELSNFLSHLEETHHDFRIDTAPLSGLAGYSVFGFGDQQEWPTEQEGYCTQAIE
VDRWMARLTGRKRAFPLGMGDVKGDELEHRLEDWRRGVHNIMVDVSQGKGLGDGISGSGD
AVESDDEDDVDYDDGETVISKPRKGTTGDLEDLKAPIPVDFTTTSKTTSTPKEMVPKTSP
TYTNLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHLCMEATPSLSCSNK
CVFCWRHGTNPVGTTWRWTVDPPDMIFQGMKQGHYQKIKILRGVPGVRSERFSEAMRIRH
CALSLVGEPIFYPHINELLAMLHREHISSFLVCNAQHPDQLAALGPVTQLYVSIDASNKD
SLRRIDRPLHRDFWERFIRCMNILREKRFTHRTVFRLTLVKGFNIEEEAAGYADLVERAL
PAFVEVKGVTYCGTSTAAGAGLSMQNVPFYEEVKAFVLALEAELNRRGLDYGIGAEHAHS
CCILLADRNRFYVKGEDGISRWHTIIDYQKFFQCVEYGKPFSPEDYVGRPTPEWALWGNG
GFDPRDERVDRKGKPKNDAPPKPKIVPAVTDIDEITPVEAAAEVVKETPKEPVGTDQLLG
RQYQRTLQMRKQLIERNRTSRVVEI
>A0A428NUC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sp. AF-6|TrEMBL
MAFSPEGRFTAIVIAFTNLPPTSNLKSLIASQLDRGRQIFRMDWANYSAPSRLDSFVEDL
VDVWHIHRTPILVAALVVLGTLRIYLTFIGRKTELVALTEAYKEPPKPKAVVEAKTPAVE
TIDEKKDIKPQGPRRIKGGIARKPSKKNEEEKDLTRPIMVLIFFSSITTKTDKIAQAYLK
ELEVKQEELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKMHGDVDYFYTFLIPSYNIDTI
NDTFLEHLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPTEGEGFCFQAKEVDKWMAKL
TSRKRAYPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGNLGEGLPGSGAAEESDVEDI
AEDEDDGEVLFEDDDTSDSKKKNGRPLDDVEDLGRMIRKDDGSTVQKAPLAVDFTTYSST
KKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRWTKSALRGRGSCYKFSFYGI
HSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFEGVKTNHYKKIKMLRG
MPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHAERISSFLVCNAQHPDQLAA
LKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLEILREKRNRHRTVFRLTLVKGF
NVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFVKALEKR
LKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKKFFDLLEERGPDGDWTPEDY
MDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A833WKB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis infestans|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLQTHPRTLPGSDAVVTSPKRKAKKKPQQTAKTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGEPPEDAKMFCNWITDMTQDFRVSKNWLNGVQHAVFGLGNAEYDEDYGTAAKTLD
RDLSDLGSPSLVSLSLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKSSSPVKAD
KDGKKWLSQKEFRRQKRAKKAQENGDKVELNEEDMMNEQFLVDEFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHSHSNCVLIAKKKFCREGVWHTWIDFERFHELIAKYYEDGTPFT
ADDYTAPTPYWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A833WKB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora infestans|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLQTHPRTLPGSDAVVTSPKRKAKKKPQQTAKTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGEPPEDAKMFCNWITDMTQDFRVSKNWLNGVQHAVFGLGNAEYDEDYGTAAKTLD
RDLSDLGSPSLVSLSLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKSSSPVKAD
KDGKKWLSQKEFRRQKRAKKAQENGDKVELNEEDMMNEQFLVDEFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHSHSNCVLIAKKKFCREGVWHTWIDFERFHELIAKYYEDGTPFT
ADDYTAPTPYWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A2P2H5E2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus flavus (strain ATCC MYA-384 / AF70)|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSTAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A077W6N3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lichtheimia ramosa|TrEMBL
MNNVVNSLLNGFSSMLALGGDTPASDQGCACAGPEGGSCCKSQQQQQPKEDNCACAPQQG
PTEIESMKLFYATLTGTAKTFATELQQRLEQDNNVKVKQLELVEITDYDNDDLLTETSVC
VFLLSCYNVEGPLDWFSKWLRDLRYDWRVDRLALQKLRYAVCGLGDSAYGEEFNVAAAQI
DKWLGQLGATRIYPLGSCDKNADQKAQFEEWADQFVKELHDKSSLEFSPAHIEYDSDAEG
EEVEDEEQQEVQIGSEDEMVDVEDMGKMATKLKTAKENREREEHEYTVAQAKAKRTIGVD
GQSTVVKKSEPREMVSPMLHKNLTKQGYKIVGSHSGVKICRWTKAALRGRGFCYKHSFYG
IQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLK
GVPGVKADRFQEASKIRHCALSLVGEPIFYPHINEFVKLLHEHNISSFLVTNAQFPEKIT
EMDLVTQLYVSIDAGTKEGLKKIDRPLFRDFWERFLDSLEALAKKGQRTVYRLTLVKDHN
TEELDNYVELVRRGKPSFIEVKGVTYCGYSGASNLTMANVPYHHEVVDFCQKLTEKLGPG
YEVAAEHAHSCSILIAQTQFKINGEWYTHIDYDKFFELVRSGKPFNSLDYVAKTPSWAVF
GAPEGGFNPDDTRFYRKNRKVAPAS
>A0A7J6LW53|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus olseni|TrEMBL
MLAGGFYRALLSKHYSGPSRTVKVVYSSRTGTSKAAAGRLKDTLESDKIRVILLPIEQYS
YEELCEESYLVLLLSTDTDGTPLPGAKDFTEQLRDAVYDFRVDKNVLEKCKVAVIGFGSE
EYPAKHYCKVAKNCDDWLAKLGAQRVSPLLCISDTRDVEKQVSRCIDLIKKAYARLDAEP
TDQRTADLEDDVESVGSEESTSDTEDGDVEDASGACGGNDKEMVTKKHRAALTREGYRLV
GSHSAVKLCRWTKHQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPVG
RSWTWAQDPPEEIVNGWLGNHAGMVKELKGVPGVTPERFEQAKRVRHCALSLVGEPIIYP
QINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAEDMKAIDRPLFEDF
WDRFIDSLTALKHKKQRTVYRMTLVKGYNISTAAEYAELLHLGNPHFLEIKAVTFCGKGD
GSAQMTMENVPWFEEVVEFAQMIIESSPWVEERYEIACTHRHSCTVLIAQKSFKVDGVWH
TWIDYDKFTQLALKYSKTGKPFAVEEYWAPTPAWAVYGAEEEGFDPEMKRHYRNGKTPEL
GKQIRAKQLREEQERSSKWLVHGQDHHRLVAIKKVEFVFDDLVDCKRTLREIAILNRLDH
TSVIKIVDLVVPEDLVKFNDFYLVGSKWILAWSDDISRVKGKQKKGRELKRQLTGHVVTR
WYRPPELIFVEDMYDEAVDIWSAGCIFAELLGMLKEVVSFPSDRGPLFPGSTCFPLSPDH
KHANDHKFHARGNKDQLNMIFNVIGTPSDEDVESFEEKDIQEYLRCFTKRPGIGIAEVFR
AASADASDLLERILVFNHKKRLTVGECLEHSYFKEVRGVELVAKDQVFLPFELESTLDEK
DMRQYFILEMQKFHPEVKIPQELTVK
>A0A3L6JH73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MSTEMPAQLREKLEHQGYDILGERGAFKACQWQKKSLLFGDVCYKQRFYGIESHRCVQMT
PLVDKCTQQCEFCWRVTPTDVGIAWNQTEVAEEDALPPRELLDAALMANQRALGGYNPEA
GARVPESKYKEARNPKHVAISLSGEPTLYPMIGLLIDEIRHRKMTSFLVTNGTRPEVIRE
MSLPTQLYVTLAAPDEQTYRFLCRPADPHSWELINETQDLLRSLNCRRVNRLTMVSGRNM
HNPRAYGSMILKGNPDFVEVKGYMPLGSSRGRLSLHNVPSHQDIRAFAEKISAITGYITL
DEQVESRVVLLSRERHPESIQSL
>A0A524G0G5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPKELREKLEKQGYHLLGKRGAYKACQWQKKSLLYGDVCYKQRFYGIQSHRCLQMTPVVD
KCTQNCEFCWRVTPSDVGISWDQLNVSESDVVPVDVLMDEVLKANLRSLGGYNPEIKRDV
SAKRYQEARNPKHVAISLAGEPTLYPRISELIRDIHSRNMTSFLVTNGTQPNVIRTMEPP
TQLYITLAAPNEIIYKKLCHPGIKGGWQRVLESQEALHSVDCRTVNRLTMVSGHNMESPR
SYSHLILMGEPDFVEVKGYMYLGSSRGRLHSENAPSHREIRSFSKKIADLTGYYIADEQT
ESKVVLLSKSKHIKKLDVN
>F0T6I1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium lacus (strain AL-21)|TrEMBL
MKTSLNEGEIKALEKKGYRFAGKYKHAAAKVCHWTKKSLVDEGVCYKEKFYGIQSHRCLQ
MSPSIPFCHQKCSFCWRDTSITKTEWNEEFDDAKTVIDDCVEAQRNLLCGFFGNARVNKK
KIKEAQDPKNAAISLAGEPMLYPDINELISEFNRRNFTTFLVTNGMTPEKLENLDDEPTQ
LYISLDAPNKTLYNEVCQPQINGGWELLNKSLELMKSFNSRTVIRTTCVKDLNMQLPEEY
AKIITKTDPDFIEIKAYMFVGSSRDRLTFDNMPSNKEVLEFAESIAALCGRKVKDHAHES
RVVLIE
>A0A2R6KGC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_9_68_17|TrEMBL
MPLAPNGTSMSDSEDGPAQVGSPNYHSENHTAAQTCGWTANAVRGDGKCYKYVFYGIESH
RCIQMTPVVKCNERCVFCWRDHAGHAYELGGVEWDDPAAVADASVELQKKLLSGFGGNDE
VPDEVFEQAMEPRHVAISLDGEPTLYPYLPELIEEFRERDITTFLVSNGTNPEMLERCDP
TQLYVSVDAPERHTFDEVVKPVDDDAWENLVDTMDILAEKDDTRTVLRTTLVKGENMRDP
DWYAGFYRRADPDFVELKAYMHVGHSQGRLDRDSMPDHEEVMAFADDVADHLPDHDEVRG
VPESRVALVAREKDTWVPKLKKGSDFWERDPVVGD
>A0A4Z0YG77|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xylaria hypoxylon|TrEMBL
MASNLTMDKARPQSSGDFLDFWHLHREVILVVAICFFSTAYMLYASLPTRRVVKKPLTRP
VATAKLAPAKPVTITTEKSELSLEALPQDVVAHEPRRIKGELRKPDATRKASGSDSSRRT
QVLVFYSSLTTTTEKIANDFARNLSASLEGDTEHKDIFFSPSVLDLAQIDYDEYFISPPK
PTDSTIAVDYFYLFLIPSYNIDTINDNLLEHLQETHHDFRIDTAPLVGLLGYSVFGLGDR
EGWPTEEEGFCFQAKEVDRWMAKLTGRKRAYPLGMGDKKQDLTNRLGEWSEGVTDVLKLA
ATTGSLGEGVAGSGDADESDFEYASGDDDDEVVVEESAAPTKKNKKTKSNIDDVEDLGRI
MKSNQADSNDSKGRAPIAIDFTTHSKPNAKKAAVQTVKEMVPKNSPTYASLTKQGYSIVG
SHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPEMIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLGMLHAERISSFLVCNAQHPDQLEALKAVTQLYVSIDASNKESLRKIDRPLHRDFW
ERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAKLVEQGLPCFVEIKGVTYCGT
STSAGAGLSMANVPFYAEVTEFVTALNKKLEELGLDYGIAAEHAHSCCVLIASGRFRVDG
KWHTRIDYTRFFELLEERGADGDWKPEDYMGAETPEWATWGNGGFDPRDERVDRKGRKIE
AS
>A0A7L2ZL75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunella fulvescens|TrEMBL
LDVSMDMWSYFYTCLVSIWLHRFYIYSAIALGISLWVVIQFTTTRTKRKVTEPRTADKLG
NGCAPRQAQRVHVAGVKIFYGSQTGTAKRFANALAEAVSSLNLPVEVINMGDYDPEDGLV
EETRSRNICVFLVATYTEGQPPESAAWFCKWLEEAASDFRVEKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQAL
CRGEKPPCSGKCKKGKCKSSGKQSKESSDHERGTSEQDNTEGEELLETSSEEEAGGTDSV
VDVEDLGNIMGHMKKAKVLLLGGGMEWSVHGVSHSGYHLVYFVCQFLQAKLNCSVICALF
SGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGTEWRWKMDQPEVILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVG
EPIMYPHINSFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDR
PLFKDFWQRFLDSLKALAEK
>A0A7C2A6T0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MNEELRKLLEKQHYAIVGNHSGVKLCHWLKQSLLYNRVCYKQTFYGIESHRCLQMTPALT
QCTHNCLFCWRHQGFTEKTFKQVDDPEFILEESIKAQRRLITGFKGDPRCDQRNWEEANN
PNMVACSLTGEPTLYPRLGEFFELCHKRGMTTFLVTNGTTPEVLSNLDPLPTQLYVSIVA
PNKEVYKKLCAPLISNGWEKIMQTLELLPSLDTRTVIRHTLVKNWNMDLKYIPEYAKLDE
IASPMFIESKGYVFVGASRDRMTINNMPSHEDIMEFSRKLSDTMGYNLAMEKEDSRVSLL
IRDSSINPKFNR
>W3XEH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pestalotiopsis fici (strain W106-1 / CGMCC3.15140)|TrEMBL
MGINEWMSEVQAARPVAYLIDLWHLYRTPTLLVTLGVLVSVYIYLLLTQDREYSVALRKI
YDEPAKSEPAPAPVVISEKSTVPVIKNPATNGPKRIKGELRKAEPKPAEPQSDEPWQVQP
LIFFSSLTGNTERTVKGLSESLADALKQDSTAAEKVLAPKVLDLTEVDYDEYFITAPKAT
ETSGAVKYVYLLLIPSYNIDTINDNFLEHLQETHNDFRIDTAPLSDLLGYSVFGLGDREG
WPSEEDGFCFQAKDVDKWMAKLTGRKRAYPLGMADTKHDLKERLDEWSRGVADVISLIGS
TGSLGEGVPGSGDAVESGDESVSGDDDGEVLFEDQTVEIKRPKKKQTGNLEDLEDLGKIM
KSSGGGQNGSAPIAVDFTTYSKPAKKTATQTVKEMVPKSSPTYNSLTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWV
VDPPEMIFNGVKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPYINEFL
AMLHAERISSFLVCNAQHPDQLEALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFQR
CLDILREKRFKQRTVFRLTLVKGFNVDDEVEGYADLVERGLPCFVEIKGVTYCGTSSSAG
AGLSMANVPFYAEVQEFVEALNKKLNDRGLKYGLAAEHAHSCCVLIASERFKKDGKWHTR
IDYQRFFELLEERGADGDWRPEDYMGLPTPEWATWGNGGFDPRDQRVDRKGRPIEA
>A0A424PVR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED192|TrEMBL
MEPRIAAKLAKQSYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGYQEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSRGLAPMVDREVLSERRESRVALIGK
EMIPVKLPEKIRDLPKDLGIAKPQKLSLPTL
>A0A8G1EFX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofollis formosanus|TrEMBL
MRSRRCEDESPRGALQKQGYQFFSPESTAAVKPCMWNKRSLKGGEMCYKHQFYGITSHRC
VQMTPTLTCNQRCLFCWRSFEYEVEKAEECPPEEIFANLRRLQKRALSGYKVSPYVTQER
FKEALEPDMVAISLSGEPTCYSRLPELIDLLNDDGYTTFLVSNGTHPEMIERCHPYQTYI
SLDAPDRETYLELCNPIEDFWDKIQESLGLLASRRSAVRTTIVKGMNDFDPAGYAAMYDA
ARPKYIEIKGYMYLGYSRNRLSRENMPEHAEVRRFAEAVAEHCEYEITDESPISRVVLME
RGE
>A0A133UP07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA259E19|TrEMBL
MKLSKEASENLEKGGYRFLGENKHSAVKVCRWTKKSILDEGICYKQKFYEDIHGIKSHRC
LQMTPSLPFCDNKCVFCWRDVDLNSPKWEGPPDDPSNILDEAIEAQRSLLSGFKGNPEAN
KKKWEEAQNPNLAAISLDGEPTLYPKLDELIEECYRRDIVPFLVTNGLHPERLEEIREPA
QLYISTVAPDEETYRKICRPLVSRAWEKLNRSLEVMQSLDCTKVLRLTMVKGWNMKDPSG
YGKHIEKAEPDFVEPKGYMFVGHSRKRLKMENMPTHKEIKDFGVALEGETAYQMVDESEP
SRVVLLSAEN
>A0A094HH25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4519|TrEMBL
MANNEYFGADIASHATENYFMALWHTYRIPLILTVFAVLLITRTVLHLKVGREKIVYTPP
PTPSEKAPLAANPQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLGDKPASKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLAPIAHDLAELEDYDEYFLGLPK
PEDASQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLEEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEEAEDDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQNESEEQDEDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIVGS
HSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYL
NEFTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWE
RFQRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTS
SSGAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGK
WHTRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRV
EGEEAEVKVETKPALVEI
>A0A8J4CWE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Volvox reticuliferus|TrEMBL
MDLFSYFVLVLKVLWLFGLAKASLNLWRTSRARSTSPKGSPVNLPPCVRERFTSRSISVK
SIINFLAQNGYYVQSGATPPVRTTCLNAATQTQNVSAVEGTAAVAAPYMKILYGSTKGTC
KQLATQLSELVSEGLLNLSPSVASVTTCGSAKCCRGADAPTAASAVAIPSDMASYEPEQL
LSEPADTLVVFVISTYEGGTPPQGAKFFCSWLEDAASDFRLGSAALSHLRFAVWGCGNRL
YEEHFNVVARRMDRQLRELGAKRFRPLGLGDEDADLDLRQQFVPWAKVLVERELQRWQQQ
QQQQPTGPAVKVSANGPAVTTAAPGTGAGATEATPTTEVDAVNPDMEDEEYEEEEEEEEE
EGAGSEMDMEDIGGAGPRRGKARTGAGAGAASAASSGPESGPPEMLNPLIRTSLTKQGYK
LIGSHSGVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNP
VGKTWKWRMDPPDTIVETALDLHTRMVREYSGAPGVKPEAVAEGLQVRHCALSLVGEPIM
YPEINALVNQLHSRGISTFLVTNAQFPDRIEQLNPVTQLYVSVDAATPESLKAVDRPLFS
DYWDRFTACLSALGSKRQRTVYRLTLVKGWNMAEVQAYASLVDLGRPDFIEIKGVTYCGS
GAASSLTMANVPYHADVVEFGQAICAARGGEYALACEHAHSCCILLARVDKFFVDGQWHT
WIDYDKFQRLVREGNDFGAEDYMLPTPSWAVFGSEQAGFDPEQMRVRKVRRHPGKSDSAV
ASVAGEAVDEDS
>A0A3P6BGQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica campestris|TrEMBL
MAFSSSIHSRLALIALLSATTFYCIHKYRRLKRLKTLSSKLNPSAATTRGKIFFISQTGT
SKALAQRLRDLLASNGVAFDLVDPRSYEPEDLPKETVAIFVASTWEGGKPPKDGEFLVDW
LSESAEDFRVGSLILSGCRFAVFGVGSRAYGEAYNAVGKELARRMVGLGGVEMVPVGEGD
VDDGEMDGVFRDWCDGVIRVLKGGSAREGAEILQNGDVGLVSDGEYVDSTDDEEEEEGNG
DIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKE
IVKGALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGK
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
ADVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASG
EPFTSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQAVLA
>A0A0S7DDM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus lentulus|TrEMBL
MAEHSTAEGLTKRDPPTNIMLTDSSFIGLLAFWHSYRLLFLVALSTVFVGLRFYRKLQSR
TKTTASSSVPPSPRSQSPEKTEKGVSLESSNKATTQKAERQPAVANGSARTTSGPKRVTG
KKPLKVAGRRGLTEDAEPLAFIQPIIFYASLTGNTERYAKILLEELRAAAQKRADLQDRE
RGLLPPQIHDLSYVDLDDYFTSAPKPPSNSPGTGYVYCLLIPTYNIDSILNTFLDHLNET
HNDFRIDTGPLSSLAGYSVFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGF
GDVKSDAESSLKEWSQGLQDVLFDILKNGGLGEGVPGSGDPVESDEELDDEDADKDNTQN
VMDLEDIKFGGDQNAAGSPIPVDFTTTGKSSSGQSTEKEMVPKTSPTYAALTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWKVDSPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLDMLHAEHISSFLVCNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFW
ERFQRCLDILREKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGT
STTAGVGLTMQNVPFYEEVAQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVKG
KWHTRIDYDRFFELLEKEKADGSSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKH
MQITAEP
>A0A650CSY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus ambivalens|TrEMBL
MVVSTLRIDTLSRIMEEMEKEKYHIIGNHSAYKKCHWTHEALTEGRYCYKGKFYGIESHR
CVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDETKLPITDDPEYIAEKSIEEHKRAVSGYL
GRKGVDPNMAKEAMKPAHVAISLTGEPTLYDRLGELIHEYHKRGLTTFLVTSGVRPDVLA
SLEEEPTQLFVSIQAPNERKHKLINRPIVANSWNLFLKTLEILPSFSSPTVIRMTMIKGF
NMSEEDAKDFAKLIEMAMPTYIEVKAYMHVGPSTLRLSRDAMPRHSEVREFAKLMEKYTG
YKIISEHVPSRIVLLSKLDKPIQIGNAWSDKWNWATKDTEDDIHGEYAEAELGSGNNQC
>A0A7C4DWJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MGLPVGLQELLRRQHYHLIGKYKHAAVKRCYWLHAALTKRVFCYKNWYGIESHRCCQMTP
ILSCPNACLHCWRLERLDLNVKWDEFNLGVLDEPSIIVREAIEEQRRILSGYKKNPMVDQ
RMYEEALHPKHFAISLAGEPTLYPYIGDLLRECHRYGITTFLVTNGLYPKVLSTLNEEPS
QLYISVNAPNEELFKSVCRPSLPDAWLRLLESLKMLQSFKCPTAVRITLIAGINTDKPQE
YAKLIKIAQPTYVEVKAYMYLGFSRYRLKLENMPRHRHVRSFAEALAEAIGYEKIAESLH
SRVVLLSRLKKPVKVA
>A0A2H4VSZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium subterraneum|TrEMBL
MLLSDPAITSLEKKGYRFVGSKKHAAAKVCHWTKKSIMDDGVCYKEKFYGIESHRCLQMS
PSIPFCHHKCLFCWRDISITSTTWKDEFDDPGEIIDECIKAQRKLLVGYFGNPGANQKKI
SEAQDPTNAAISLAGEPLLYPPINQLLEEYKKRHFTTFLVSNGLSPDKLGKLNPEPTQLY
LSLDAPNPEIYKKICDPQVKDGWDNLNQSLDLLSSFNCRTVIRMTSVAGYNMTHPEEYAR
IIERSNPDFVEIKAYMYVGSSRDRLTFDNMPRSKDLESFAQEIASLCGREIVDKSSESRV
VLLS
>A0A1A7ZDH8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
MLRLLLFLSHITAHAASSDTNAQQEAPRPGESYLLWVWTNRLYVYSAAALVFGTWFLLKV
TQQEKHTDSAGPSCTSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVD
MKNYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAW
KVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVDRIESSSEEDESGLA
DERTSGSVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGERREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCAL
SLVGEPIMYPEINTFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
KIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEV
KGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPRYEIACEHEHSNCLLIAHTKFKV
DGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQR
RNKTKDVSGC
>E9DIV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides posadasii (strain RMSCC 757 / Silveira)|TrEMBL
MPDETFASGAQRALSLWHSYRGYALVLLPAVFILSHLIAARDKTAEASPPSIPSPPQSSK
AKQSRPTSGTEPPTSSTTPEEGTPSPNGAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDA
TKEISIQPIIFFSSLTGSTERSAKRVLERLNTEPLKDSRHSSRLLAPQLYDLSYVDFDDY
FVSPPKAPESNPNVLYFYCIIIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAV
FGFGDKEGWPTEEEGFCSQAKEVDKWMAKLTGRKRAYPLGLGDVKADGDKALDEWCSGMQ
EVLCDMVTNNGALGEGVPGSGDPLESDEEDVEDDEGVPNPGSRPRKARRAEITDLEDIKF
GGDASAKQGSDIPIDFTTYSKTSTSFATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGVK
ICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVS
MLHSEHISSFLVCNAQHPDQLAALDRITQLYVSIDASNRDSLRKIDRPLHRDFWERFQRC
LDIIREKTHVQRTVYRLTLVKGFNIDDEVVGYADLVERGLPCFVEIKGVTYCGTSTSAGA
GLTMQNVPFYEEVAAFAVALNEELNRRGLGYGIGAEHSHSCCILLASRRFHVDGKWHTKI
NYERFFELLEREKAEGVSFTPEDYMSETDEWALWGNGGFDPNDQRVYRKGKNKGNMSDAG
SVPKGGVVEI
>A0A078I678|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica napus|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLNPSSRRGKIFFISQTGTSKSL
AQRLHKLLESNGIAFDLVDPASYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSGCRFGVFGVGSRAYGDEYNAVAKEMSRRMVGLGGAEMVPVGEGDVDDG
ELDRAFNEWCDGVIRVLKGGSAQAREANEITQNGVVESEEEYIDTTDEEEEEDSNDIVDL
EDIAGKAPSRKNGVVKVTKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKG
ALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIST
FLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQ
RTVYRLTLVKGWNTEELEAYFNLFNIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFT
SRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>A0A497HZS7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococci archaeon|TrEMBL
MDQEIRNLLRKQRYKIVGEHSAVKLCHWLKKSLMENRVCYKQKFYGIKSHRCLQMTPSVI
SCTHKCLFCWRPTQYTFSTIENPDPPEFIVEKSIEAQKELLSGYWGVLDRVDKEKLKEAI
VPNNVAISLAGEPTMYPLLSDLIDEYKKRNFTTFLVTNGTNPKVLENISLPWNLYVTIPA
PNKEIYKKLCIPQIPDGWERIMETLELFPSLNTRKVTRLTLVKGYNLKNPEEYAKLIEKA
SPEYIEAKAYMYVGFSRLRLNIENMPSFSEIMSFAQQLEAMTNYKIKDSSEDSRVVLLVK
E
>A0A814BGH8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTIDLYIFAASSALTGLVFYYLAGAEWSLWHLFAIPLYTFVFVVFLSLSIIKRFKSLSKP
LQSLTKIIRQEKNGITIVFGSVTGNCRTFAQLTYDKLSKELNYQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDDTPPPSAKWFVNHLQDAATDFRVSKNELEKLTYAIFRCGNS
FYNDNFNTVAKELDRCLSELGAKKLIPTELADENSGKSIYGGREGHYSKWSSQLKSAFQS
PKTDKCDCSNENSIKCCQSLTNNDHPIEKKENDEQLRIESDDDDEDGGCKNGNDDIMDLE
DMGDYMATHSPTKTTKGPPKEMITPVIRKSLEKQCYKLIGTHSGVELCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPGLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAMENH
YKIINTFKGVPGVLPNRLAEAMKIRHCALSLVGEPIMYPHINELIDLLHSKQISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKRIDRPLFRDFWERFLDSLRALKDKGQRTVYR
LTLVKDYNTEEIEQYAKLVELGHPDFIEVKGVTYCGDSNASHLTMANVPWHEEVVTFVQF
LCDRLPQYDIACEHEHSNCLLLAHNKTREIVSFVREANDTLVINLIKSGIKTQSVHRMEN
GQYQVDFSVNGSPFCFSVAIDDHIDKNRQLVNDKIPDFIRELEQTLGQVSRKIYNLNRER
GKQQSNTQQEQHHGPTHKKRTSFRGEPAQNFIDREDYLQGAQAAIGWRHPAPARQRQHVA
PDRGPRDVPNPQPSVAPSQSQNYDYIYAPYYTSGPRANVHSQAQYGQFYRPSRPPTVAPQ
YYSANRGPYNTQGQQ
>A0A8C0DTI8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Balaenoptera musculus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAKAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEDAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQRGSEAVEPGSHAQEGSHQRGAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSAVKNEASERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYARLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVNLIADYEIACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRK
NKSKDISGC
>A0A7J4MQU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanoarchaeota archaeon|TrEMBL
MIPKEVKKILKRQHYEIVGKHSAVQTCRWTKKSLKDEGVCYKEQFYGIKSHLCCQMTPAV
MWCPNKCIHCWRAIEMTLGSELEGDVDSPIEIIDGCIIAQQKLLTGFNIDSNSPKKQLSR
ANQKKLSEAQEPMQFAISLSGEPTVYKHLGGIIDELRKRGKTSFLVTNGLYPEKLQELKD
KKQLPTQLYISVNTSNKELFKRFHRSSKEDGWERLMKSLEIMSTLKNTRTVFRMNLVRGL
NMNTEFVKEYAELIKKANPMFVEIKGFMSVGFARDRLGYDKMPTHREIKDFAKLLVNELD
NDMKILDEKIVSRVLVLGKDKNQLKIPKGYL
>A0A8B9K2A6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
AWLVDGAWSYTEGWLWMVWQSRLYVYTAAAVLLGLWLTVNMTLKKKKTVLTSSPPLSKSE
KKKEKLPEKEKVIHVEGVRIFYGSQTGTAKGFARELADDARATGFHSEVFDMKDYDPDDR
LSDECTSKMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGN
SEYVGHYNTVGKNVDKWLWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRLQ
ALARGEKKACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESAGEEEKAHG
SVIDMEDLGNVMNHMKKAKQSEEESQRGKLSKLNGVMKTEGEEEAREMITPALREALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGE
PIMYPEINAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRP
LFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGVTY
CGESSASSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGEWW
TWIDYERFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNKTK
DISGC
>I7CW10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema sp. (strain J7-2)|TrEMBL
MSDSANPGADGATRDAAEADGGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNI
FYGIESHRCIQMTPVVRCNERCVFCWRDHQGHAYEMDDVAWDDPEAVVDASIDLQKKLLS
GFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPE
MLRDCDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMHVLAEKDATRTVLRTTLVK
GENMHNPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPEHDEVIEFAEEIRDHMP
GFDEVMGVPASRVALLSQTKDTWVPKLQKGSEFWERDPVTGD
>A0A671Q917|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWRNRLCVYTTAAVLIGVWLTVNM
LFKKKKMVDPISPLLYKSVKNQELSPETEKVLHVSGVKVLYGSQTGTAKGFAKELAGGIS
AQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASMDF
RYGKTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWETKFLKRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNS
EEELMESSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIRQFRG
VPGVHPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYE
IACEHEHSNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPS
WAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A0P8ZD16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. EP1|TrEMBL
MDVKPNMPEEIVNLFKKQHYALVGHHSSVKLCHWLKESIKHNRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVEMPEPLDDPAFIVEESIKAQRKLLSGYWGVKDQIN
VKKLEEAMEPRHAAISLSGEPTLYPMIGDLVEEFHKRGFTTFIVSNGTEPEVLEKMLEEN
KLPKQLYVSLTAPDEETYQKVNVPMIPDGWDRINRTLELMRDLPVRTVIRLTLVKGENMH
NPEGYAKLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVKHLPGYHIE
DEYPPSRVVLIMRDDVSKADRVIKH
>X0JHA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium odoratissimum NRRL 54006|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFYINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A1M4MM90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus chikugoensis|TrEMBL
MRSEACKALRKQGYQFITPNSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LKCNQHCLFCWRSFEHEVVEEEECPPEVIVANLRRVQKKALSGYKVSPYVEPEQFAEALA
PTMVAISLSGEPTCYSSLPELVDALNADGYTTFLVSNGTKPDVLARCRPYQTYVSLDAPD
RETYLALCRPVEDYWDCIQESLAGLRDRRSAVRTTVVRGYNDFSPERYAAIYQDSGARFI
EVKGYMHLGYSRNRLQRDRMPEHHDIRAFAEKITEHCDYAIKDESPVSRVVCLERKI
>A0A8C0APG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Buteo japonicus|TrEMBL
MDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASFEGIED
KVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLSLPVEVISMGDYDPDD
CLSEETTSRNICVFLVATYTDGQPTESAVWFCKWLEEAANDFRFGKTYLKGLRYAVFGLG
NSVYVDHYNTVGRNIDRWLWMLSASRIMTRAERDCNVAQSKHGSIEADFEAWKAKFLSRL
QALCRGEKKPCSGKCKKGKCKSLGKQSKESSDHEHGASEYENTEAEELFETSSDEEADGE
EAGGTNSVIDVEDLGSIMSHMKKAKRERELAEGDTGTSLTHKNAGRKEEGEKREMITPAL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGEPDFI
EVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKF
KINGEWWTWINYDRFQELVREHERSSGSKTFTAADYAARTPHWALFGSRERGFDPLDVRY
QRKNKTRDISGC
>A0A7L3TBD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rissa tridactyla|TrEMBL
LNVSMDTWNFSYTCLVSLWLHRFYIYSVVAFGISIWIIIQFFTTKTKKKGEKSNGNPAAS
EGIKVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFAKSLAEAVISLNLPVEVISMGDYDP
DDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAVNDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKVKFLS
RLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDHEHGASEHENTEAEGLFETSSEEEAD
AEEAGGTNAVVDVEDLGNIMSHMKKAKVLLSGSDFASFMSVVVLLAGTSGGIVGAWFDTC
FQLQFCRLLIYFLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATP
SLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFE
EAMTARHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVS
VDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLI
ALGKPDFVEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNC
LLMAHKKFKVDGEWCTWINYGRFQELVREHERSGGAKTFTAADYAAKTPRWALFGSRERG
FDPLDVRYQRKNKARDISGC
>A0A0E9NJ67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saitoella complicata (strain BCRC 22490 / CBS 7301 / JCM 7358 / NBRC 10748 / NRRL Y-17804)|TrEMBL
MVQPIEPVSMDGFSYCGRDAMYVELPGGHKHCRASPGDIRLVLDRNSTPAQSLPGHWYTA
QLLHYGFKPVSTTTKPIMRKLLSDAFDTGKLVVPKRIAEVEVELKRLWKDVLRRRGEDAE
AAKERARLLEAVTQGLITKPGPKPGGPKPYSYKSTNPIAGNVPGHLLLNGSTKPYTPRGP
PSPESTRSPAPMLIPPTSGVTPLASDTYAEISTSPSSSYQKRRRESNLSTSSYESARIEV
RRRAEKACEHCIEVKRKCIFTAPTGPCVRCEHVGVTCILRPNPESPPLAMRPSLRVRRSR
GACTQCSKGKRRCELLGGIGPCLRCREMDWACELPHRATMDGHGQPHLPQESSEEPMESV
NGNGDQDGDEYGNAPGPFQAVWSPELRPQLERERVTLPSLASLDILDRRVERSGDGHAKK
MELASLSEAGGGAVLWSNATTPMAHVQTESAVQSAKGNLETQNSTAEEDFESTVRLELEW
GVRGRASEAFPNFCPANRHPSKTRTSFLGQSSTMADQTAQSIPDELDIFPPWVLRVGDFY
QEHRVTFLVAFVSIWAFMFYRQSIRPSVYEPGFKSTDEKNDGAAQDVNTEKSAEKEVDSK
EVQKEDGAAAGKKAKGQKKFSGRGKVTKKAKRTSSSDEESTTAPTTVSSTPANLTPTTTD
DTETSSGPRVRIFFSTMTGQTEKHATALHQHLISLLPPANRPTLQNLDYLPDLDELFTSP
DGPSTYYIFLLPSYAIESPVEFLLSTMEETYNDFRVGAKPLRGLGGFAVFGTGDKESWGG
DDEFCYQALQVDRWLGKLGGKRVFPVGMGDVKTDVKERIGEWAGGVADALLDPEQNYVED
ASDESDVEAEAEDEEAEANKLVDVEDMGAIMKRSRDAALSTAPKEMVSKASPTYAALTKQ
GYKIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMETTPSLACANKCVFCWRHG
TNPVGTTWRWKVDPPEQVLEGALEGHYSKIKMMKGVPGVRADRFQEAFRVRHCALSLVGE
PIFYPHINEFLEMLHAKRISSFLVTNAQHPDALAKLGQVTQLYVSIDASTKDSLRKVDRP
LFKDFWERFLECLEILADKGQRTVYRLTLVKGFNIEEVEEYVDIVRRGRPCFIEVKGVTY
CGSSEDSTLTMSNVPFYHEVVDFVTQLTTRLAAEGLSMPTYEIAAEHAHSCSVLIGQTKF
KINDQWHTHINYDRFFELLESGKPFDVMDYIAPTPEWAVFGNGGFNPEDVRVDRKGRPKV
EKVVPQAKIVEVPTMS
>A0A6V8CCB6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPTLKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLTGFGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYTRLAEYMDLCHQHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQIFDDVCRPKWNSGAWEQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAALDR
RADPDWIEAKGYVYVGHSREHLSIDNMPSHEDILAFSESLAPQVDMRILSESRPSRVALI
GNEMVPIPIPEASMHFPEDLGIASPVKKLKLADLS
>A0A8C6AWI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monodon monoceros|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINKFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKENSS
FPSASEEVYIQHISKE
>A0A830G2T0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermogymnomonas acidicola|TrEMBL
MITVKKREALNAYTEIYKKQHYGLVGSHSAVKVCHWTKSELTGGPGCYKGDFYGIQSHRC
IQMTPALNACTENCSFCWRFQGFDSMHISYEDDPEFILEESIRQHKKLLSGFKGNPKVSE
ERWKEAMEPKHIAISLTGEPTLYSRLGEFIELAHRRGMTTFLVTNGTLPMVLEKLDPLPT
QLYVTVAAPNEKIFKELLSPAIGNGWQNLMRTLELLPSLDTRKVIRHTLVKGVNMPYVDE
YARLDMIGMPDFIEPKGYVHVGQSIARLGIENMPSHADIMDFSRALAERTGYQVAGERSD
SRVALLARDPERARIRVS
>A0A139CPF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp. T328-1|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVRGEGECYKARFYGIDSHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A897MTF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natranaeroarchaeum sulfidigenum|TrEMBL
MSDSDGPKQVGNPDYHSENHTAAQTCGWTANALRGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPEAVVDASIRLQKKLLSGFGGNEQVPREVFEESM
EPRHVAISLDGEPSLYPYLPELIDEFHARDMTTFLVSNGTNPEMLERCEPTQLYVSVDAP
DRWTFDEVVKPVEDDAWERLVDTMDVLAEKADTRTVLRTTLVDGENMRDPDWYAAFYDRA
DPDYIELKAYMHVGHSRGRLDRSSMPDHDDVVAFAEAIREHMPDHDAIKDVPDSRVALVA
KDADTWVPKLEKCSEFWNEE
>G9MSC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypocrea virens (strain Gv29-8 / FGSC 10586)|TrEMBL
MIDHADRPAKVLVFFSSVTTKTEKIARDYINALEIFLDQKAKETSSKFLKPELLDLTEID
FEDYFVSPPKSAEDAAYFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYS
VFGFGDKEGWPNEDEGFCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHAERFTEWTSGV
QEVIAQAAQTGFLGEGVPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDV
EDLGKMIRPNKDGNEGARKAPLAVDFTTYTSANKRKAQAPIIKEMVAKNSPTYTALTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPEMIFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEP
IFYPYINEFLAMLHNERISSFLVCNAQHPDQLAALKVVTQLYVSIDASNKDSLRKIDRPL
HRDFWERFLRCLDILREKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGV
TYCGTSTSSNAGLSMSNVPFYWEVCEFVKALDKRLQEKGLGYGIAAEHAHSCCVLLASNR
FNVDGKWHTHIDYQKFFELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRK
GRKMEAIVAREAPE
>A0A395HBT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus ibericus CBS 121593|TrEMBL
MAESSATEGLLAFWHSYRLPILLALATVVVLLRAYGKAQPKSKTATASSIPSSPRSHSPE
KSEKIASNHDEEPIVKESNTQVVEKESAKPGPKRVTGKKPAKVAGRRRGSDQEPAVSFIQ
PIIFFASLTGNTERYAQALLEDLRAAARDRADPENRDRALLPPQIHDLSYIDFDDFFITA
PKPPSTSPGTRYVYCMLVPTYNIDTVLNTFLGHLDETHNDFRIDTAPLAGLAGYSVFGFG
DKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFADVKSDPESALKEWSHGLQDILG
EIVDNGGLGEGVPGSGDALESDEEDLDDDESDSKANGRKKNKAQLVVDLEDIKFSSETGS
SAPIPVDFTTGGKPAAPATEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRG
RGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVK
EGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFL
VCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQ
RTVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYE
EVQQFVTSLNKELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEK
EKADGTSFTPEDYMKETEEWAMWGNGGFDPNDERVYKKGKKKAIQAAAEAQG
>A0A831VBL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoproteus sp|TrEMBL
MSCEEEPIGRHHAVVGPRLVIRAGTARRLVEAHYGVAGHATVELCKWTRDALDGEGSCYK
VKFYNAPAGGSHRCVEMSPVGMVCSNRCIYCWRPTQEFDEFIPEEWWAMEPEEVVKGVLK
ERERLLSGYWGHEKAQERVKEALAPTHWAISLSGEPTLYPKLPQLVKLIRSLPHTKSIFI
VTNGQHPEMLERLVKEDALPTQLYLSMNAPNKELYYLINVPVMNKEDAWERWLRSLDLLA
AMPTRTVVRITLIRGMNYDERYIPLFAQLVKRGQPHFVEVKSYMHLGYSTRRLRREDMLA
HEEVVEWAKRLRDELERIGARYAYMDDDERSRIAVLQNLDRYVDRWIVPPQAR
>A0A3P9J2H8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
MLIEAMAKCLMVVLFYARCAFASDVNAPQTGSSLSENYLALLWHHRLYLYAAAALVVGLW
VSLKVALSRKSGEKDAVLSGAIKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKALG
FPAEVIDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYG
RTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSI
QADFQAWKGKFLSRLQALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEVELVESS
SDEDESGLTGEKRSVVDLEDLGNLMKNAKKAKGKNGPQQDGEVVKFSKLNGVKKIDDDDD
GERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALDKHQDMIRQFRGVPGVKPE
RYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLEPVTQL
YVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYA
ELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAAMLPEYEVACEHEH
SNCLLIAHKKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDYMARTPSWALFGAR
EQGFDPADTRFQRRNKTKDISGC
>A0A0G2JA69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emmonsia crescens UAMH 3008|TrEMBL
MAGDALGIAAQGLFSLWHRYRVPILFLAPVVFAVVQLFPRNPKPDTTSPASLPLSQNNKQ
TRHAKSNEHEVEPLSRNDSPTAGQPKREGSRSSSADSSNKRAKQPLNGPKRVHGTKPAKN
GAKNRTNPEGLAQDIAIQPLVFYASLTGSTEAYAKSFCDRLQQTAIPLLENSKGTILTPE
LHDLSYIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDETHHDFRID
TSALSELAGYSVFGFGDREGWPTEEEGFCSQAKEVDRWMAKLTGKKRAYPLGMVDVKGGN
IEQVLSEWCDGLRDVMFDLMASGGLGEGVPGSGDPVESDEEDINDDDEENDENNENSRKK
GRKEQIVDLEDIKFGVSNDKKPSTDPQLLPIDFTTQSRAQPAKPAPQLEMVPTSSPTYAA
LTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFC
WRHGTNPVGTTWRWKVDPPDLIFDGVKTGHYKKIKMLRGVPGVRAERFAEAMRIRHCALS
LVGEPIFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRESLRK
IDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCFV
EVKGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELVRRGLGYGIAAEHKHSCCVL
LASNRFYVNDRWHTRIDYDKFFTLLEKEKSDGIPFRPEDYMRETEEWALWGNGGFDPKDT
RVYTRGRNKAKLNAALKESQANTASVEG
>A0A099T020|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcoides methylutens|TrEMBL
MSSKDKEELITIPEIPDFEALLKKQGYSLAGTHSAVKTCLWLGRSMKGEGECYKSRFYGI
TSHCCLQMTPTLRCNQRCLFCWRPTEAEVSFPKDWDSPVEIVGSSIKAQQKLISGFGGSA
PRERWEEANQPKHVAISLSGEPTLYPHLPELVEEYEKQGFTTFIVSNGTVPDMMERIEPS
QLYMSLDAPDRETYEKVCNPKSPELWDNINRSLEILGKKNNRKAIRITLVKGMNMIDPAG
YARLIEIANPDFIEVKAYMHLGFSRSRLPREAMPSHEEVVSFAKELAEHLGYAIADEVEV
SRIALLSKDGKVTYLD
>A0A7K7U2F9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ibidorhyncha struthersii|TrEMBL
LDVSMDAWSFYCTCLLSLWLHRFYIYSVVAFGISIWIVIQFFNTKTKKNVTASEGTEDKL
VNGYATLQAKEVYVAGVKIFYGSQTGTAKKFATGLAEAVISLNLPVEVISMEDYDPDDCL
AEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQA
LCRGEKKPCSGKCKKGKCKSSRKQSKDNSDHERGASEYENTEAEELFETSSEEEADAEEA
GGTNGVVDVEDLGNIMSYMKKAKSGIAVQRKTNDYFVYVLSHQDGGGILSSLVTDALIYF
LFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEVILQEAIENHRNMIKQFKG
>W0K6M5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium sp. DL1|TrEMBL
MPKQVDDPDYHHENHTAAQTCGWTANALRGEGTCYKHAFYGIRSHRCIQMTPVVRCNERC
VFCWRDHAGHTYELDGVEWDDPEAVVDASIELQKKLLSGFGGNDEVPRERFEEAMEPRHV
AISLDGEPTLYPHLPELLEAFHDRGLTTFLVSNGTRPEVLRECDPTQLYVSVDAPERATF
DDVVGATEDDAWEKLVDTMDVLHEKDETRTVLRTTLVGGENMTNPDWYAAFFERADPDFV
ELKAYMHVGNSRSRLDRSAMPNHEDVLEFAEAIQAHMPEHTVLKDQEVSRVALLARERDT
WVPELAADSEFWSDEPASAD
>A0A7L2UED0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Balaeniceps rex|TrEMBL
LDVSMDMWNFFYTCLVSLWLHRFYIYSAVALGISIWIVIQFTTTKPKKKGEKSNSNPASP
EGIEDKLVNGYATLQAKEVCVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGD
YDPDDCLAEETTSKNVCVFLVATYTDGQPTESAAWFCKWLEEAVNDFRFGKMYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCSGEKKPCSGNCKKGKCKSPGKQSKESSDHEHGASEYKNTEAEELFETSSEE
ESDAEEAGGTNSVVDVEDLGKIMSHMKKAKSGLGSQEAVCLGWKGGYQGSTGICVPHLKE
GEGGKTLPAACYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTA
KHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDAST
KESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYVDLISLGKP
DFIEVKGVTYCGASSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAH
KKFKINGEWCTWINYDRFQELVQEHERSGGSKTFTAADYAARTPRWALFGSRERGFDPLD
VRYQRKNKVRDISGC
>A0A0E3S5H9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina lacustris Z-7289|TrEMBL
MPLEEQKENSGENFPEIQEENRGEEQTSLPFDIPDFATLLKKQGYALAGHHSAVKTCLWL
RKAMNDDGFCYKSKFYGVQSHRCLQMTPTLVCNQRCLFCWRPTEVPVPMPGEWDSPEKIV
EESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEKRGF
TTFLVTNGTVPSMVAKVNPSQLYMSLDAPDLDTYLRVCQPKSPALWDRINESLDIMKEKC
SRTVIRTTLVKGVNMFNPEGYARLIKKASPDFVEIKAYMHLGFSRFRLDRSAMPTHAEVL
EFSKELAKHLGYEIADESEISRVVLLSKDGKKSPVNSPPINWQACNSAPVDQPES
>A0A0E3LGB6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei WWM610|TrEMBL
MPLEEKKEEQENFGENLPEVQEENTGEEPTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQSKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYIRVCQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEITDESEISRVVLLSKDGRKSPVKKK
>A0A2H1EED1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotalea sinensis|TrEMBL
MSCSGETLEVDNEFIQIKPLILGQLKKAKYGVSDHATVELCHWTKKSFKDEGQCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPVEKVAPPEVIMVNLMEERNKLIM
GHYGDPKSNKEKLDESLLPSHYAISLSGEPTMYPQLPDLIKYLKSLKNTKSIFLVTNGQE
PEMLERLRDENALPTQLYLSTNAPNQEIFALVNRPKYQDAWQRWNTSLELLSELDTRTVL
RFTLIKDYNSDEKLIPSYSEMINRSNVHFIEIKSYMHVGRSTNRLQYSNSLSIAEVRDFV
DKLSRESKTYSIMDESEISRIVVLQNQQRFTDRWISSYSDTN
>A0A520K3K3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon ANME-1-THS|TrEMBL
MEPRAILNYHEATRATLERQGYHFIGTHKHSAVKSCLWLRKSLRGEGNCYKGTFYGIRAH
RCIQMTPSIFCNQRCLHCWRPLEAFNIAVEEAPVMWDSPRELVDACIGEQRRLISGFKGS
QKTSADVFAEAEVPKHAAISLIGEPTLYPYLKELIEEFHARGMTTFVVTNGTNPAVLREI
RPYQLYLSLNAPDEATYTHVSHAQYWPRIQESLEEMRRLNAEARTRTAVRITCIEGVNLK
NPEGYAGLLRIAQPDFIEVKAYMHIGYSRKRLTRDAMPTHARVKEFAHEIAERLAPSHYA
MVDESEVSRVVLIASTNFLKERLIKK
>A0A366NXG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella moniliformis|TrEMBL
MVSLVVFPWSQILPLTLTDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKAEIVAFKK
VYEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDSTRPVAP
LVFFSSITTKTAKIAEAYIEDFCGKLDELSKLSSRQFLKPELRDLTEIDFDDYFLAPYKG
HGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWP
TEADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTG
SLGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKGARDLDDVEDLGRMIKKDD
GSTTQKAPLAVDFTTYGSSTKKTVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCR
WTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPP
ELIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLH
AERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDI
LREKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLS
MSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYK
KFFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A7C5U022|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MTIDWKAVRERREEFWSSNPVYRAIYERLTKQGYHIIGTLGAVKRCHWTREAIVRHRFCY
KCLWYGIESHRCIQMTPVVVWCWNRCLHCWRVEPEDIGMHWDDTRLPVVDDPEVLVEESI
RVHRQIVAGFKGNLHADQKMVEEAMRPKHAAISLAGEPTLYPRLGELIQEYHKRGITTFL
VTHGTRPDVLRDLETEPTQLYVSMEAWDKKSYEYFNRPLVPRAWELFQETIELVKSFKSP
VVYRITLVKGFNDHEEALRKFAEFINKGYPHYVEVKAYMYLGVSRERLSASNMPSHSEVR
NFAEKLAELTGYELLSESIPSRVVLLSRLKNPIRHGEGCPGGVECPEKYAPVITEEYEEA
GS
>A0A1D8PPU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida albicans (strain SC5314 / ATCC MYA-2876)|TrEMBL
MGFGQILLFACSILYLSTGGRWTVVALVFVLYILYNKDQQQQQQPPQPQQQQQQQQQQQQ
QQQPPQPQQLKPSVPPLAKPKKESPIYAVDFTFSSKAFTPSTTTTFPIRRVIAPRPKRSP
KIFTASKPIVQQQQQQQQRQPVLTKTTVELKKCQIYIFYTTLTGSSQRIAKSLYEKLQNL
ENLELEPKLLSLDDDVDDLEEYFLNVPTQNDNNCIYLLVLPSYETDSPIDYFLEHLIDTA
QDFRIDKYPLRKLIGFSVLGLGDSESWSHDNKFCYQAKLADKWLGKLGARRLYPLGEICM
KYEGEPKAQEWIQNFASLIVNNDNEPFYIDDNNNDDDIDDSDAEESEGSDDADTLVDVED
MGDIIRKSGKATTIGGGGIETKEMVAKDSPTFKSLTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEKVMAG
ALEGHYQKIKQLRGVPGIQMDRFEEAFKVRHCALSLVGEPIFYPYINEFVGMLHEQHISS
FLVCNAQHPDSLAKLTKVTQLYVSIDAPTKKDLKKVDRPLNSDFWERLMSCLDILRTIQS
HQRTVFRLTLVKGFNMEDIESYADMVERAKPSQIEIKGATFCGSSNGNGNPLTMQNIPFY
EECKNFVENLNKELQSRGLDYDIAAEHAHSCCILVADKKFMINGKWHTHIDYPKFFELLE
SGKEFVDLDYVKETPEWAVWGSQGAGFNPEDTKYDRKAEKLKKKAIRDEQAKKLVEQQQQ
QQQQQQETVQAKR
>A0A178ZCG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fonsecaea erecta|TrEMBL
MDLGEAGATPVILADWLDRLLTCWHENRVVLSTLLGLCVFAVIVRRRHARKIAQRDSLTL
QKAEWPAQNDDTHVQVAKDERVDVSSRDSSSLTSGQARKPRTAAAAARVVTGRKPAGSRG
GQAVLQRRRESSQIQPLIFFSSLTGTTERLSKQVATDLEEVSLAQPAILRPQVYDLSYVD
LDDYFISGPKTPAPSADVSYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLA
GYTIFGIGDKEGWPSEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSNVDKSLKDWT
GGVCGVLMEVSKTGALGEGVPGSGEPVESGDEDEPEQGDDEEVEFPDSGRNKRRKLANTT
DLEDVGGKASSYAAPLAVDFTTYSSPPSAPGTLKAMVPKESPTHAALTKQGYTIVGTHSG
VKICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRW
QVDDPQLIFEGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEF
VGLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFN
SCLDILREKRFVQRTVFRLTLVKGFNIDDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSA
GAGLTMQNVPFYEEVVAFVEALDQALAKRGLEYGIAAEHAHSCCVLIASKRFLIDQKWHT
LIDYAKFFDLLESGRDFAPEDYCRATPEWALWGNGGFDPRDERVDRKGRPKDKKPGDDVG
ADKNGARTGEAKVELEF
>A0A842L923|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriales archaeon|TrEMBL
MFISKFEKLKRLERMGYRFVGKNAHTAVKTCLWTKKSILDEGTCYKQKFYGIKSHRCLQM
SPSVFFCQQKCLFCWRDLRYTKTEWDGDYDEPADIVDECINAQRSLLCGFFGNEKANKEK
LIEAQEPNNAAISLAGEPLLYPMINELIKEFHKRKFTTFLVTNGINYKALESLSEEPTQL
YISLDAPSKKIHKKLCRPQTENAWEHLNRSLELLPTFNCRKVLRITAVNRKNMTKPSAYA
SLIKKAQPDFVEVKAYMYLGYSRQRLEMENMPLFFEVYEFADKIAKLANMDIIDKSNESR
VVLLG
>A0A890CYX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida auris|TrEMBL
MTSGTPILAICSLIYWLTGGRITFVAAAWCALWFHKGKLQPFTAASSAPPITKPVKSSRI
MEVDFTNSFTPDSKTEFPKAMPLKKKTRRTREAKIFKAAAKSGKLSKGVSHLTTNSVQLK
KCPIYIFYTTLTGSSLRVAKALHQKMANIDGIEVPPRLLSLDDDVDDLEEYFLRTPKSEN
PPVYLLVLPSYETDSPIDYFLEHLTDTYQDFRVDKYPLRTLAGFAVLGLGDSESWPGSQF
CYQAKSADKWLGKLGARRLFPVGEVCMKHEGEPKSQDWINGFSELMVDDQPFLFEDDPAA
FDSDAGSDEEEAQAEDENVVDVEDMGAIIRASKNKDAAVAEPKQMVAQDSPTYKSLTKQG
YTIVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGT
NPVAKSNWRWEVDPPEKVLEGALDGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGE
PIFYPHINEFVGMLHSRHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKNDLKKVDRP
LNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGA
TFCGSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTK
FKINNVWHTHIDYPKFFELLESGADFCDLDYIQKTPDWAVWGAEEGGFNPADTRYDRKAE
KLKKKQARDEAAAKALQAKKSESIKASSEFSEHTRELFVS
>A0A843FL05|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MAFTKEEQAKLEYSGYRFVGEHGHAAAKICHWTRKSMVNEGVCYKEQFYGVQSHRCLQMS
PAVPFCNQKCSFCWRDLSQTRIEWEGEYDDPKTIIEGAIKAQNNLLCGFGGNKKADKKKL
EESKKPTNAAISLAGEPTLYPEIDELLAEFHRQDFTTFLVSNGMYWEKLGSLENEPTQLY
VSLDAPNEKVYKELCNPQINDAWNNLNKTLELMNSFNSRTAIRITSVKGKNMINTDEYAE
LMNKANPKFVEVKAYMFVGSSRKRLSLDNMPSHQDVRDFAQEIADKTGRELTKEAEVSRV
VLLE
>A0A1R3IYB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corchorus capsularis|TrEMBL
MAPSSLSTRLTLLALLSGATFYFLYKSRRRLIPLKQLSLIPNPRKGKLFFISQTGTSKAL
AERLHKLLSSNNIPFDLVDPQNYEPEDLPKESLILIVASTWEDGNPPQNSKFFVNWLAEI
STDFRAGNLLLSNCKFAVFGVGNRAYGETFNAVARDLGKRLRGLGATEMVAVGEGDVDGD
IAGKGPSRKKLVNVAETNGKPDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVDT
AIDLHTKMIKQMKGVPGVTQERLTEGLYPRHCALSLVGEPIMYPEINMLVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALNEKYQ
RTVYRLTLVKGWNTEDVDAYSKLFNIGKPDFVEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALALKSDGEYEVACEHAHSCCVLLAKTEKFKVDGQWYTWIDYEKFHDLVASGKPFK
SEDYMALTPSWAVYGAEEGGFDPDQSRYRKERHHKPKTTE
>A0A850V5K5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chloropsis hardwickii|TrEMBL
LDVSMDTWSYIHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTITRTKRKVTEPGTPDKLG
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPETVLA
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKNFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDKWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQLQAL
CKGEKKPCSGKCKKGKCKSSGKQSKESLDHEHGTSEHDNTEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGHMEKAKVLLLEGVWSGQVLAKLNCLMIRAFFSGYKLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEV
ILQEAIEKHQNMIRQFKGVSGVKATRLEEALAVKHCALSLVGEPIMYPHINRLVRLLHQH
GISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALA
EKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANVPWH
GEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKVSLPGHAWPW
>A0A8C4VV04|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gopherus evgoodei|TrEMBL
MDASVNTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWICFQFLATKAKKQDEKSTEKLTLS
KVTQDVLINGYTKPKMKEVYVTGVKVFYGSQTGTAKGFATILAEAILSLNLPAEIINMRD
YDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCKWLEEAVNDFRFGKTYLKGMRYA
VFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEGDCSVAKSKHGSIEADFDAWKAR
FLARLQALRKGKKKPCSGNCKKGKCKSKGRQSKEGSDREQRVSEQENTEVEDLFETTSEE
EAGAEEDGSSNSVIDVEDLGKIMGHMKKAKKECELEEEAGKTGPSQQSSGKNEDSERREM
ITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHKSLIKQFKGVPGVRVDRFEEGM
VVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTNAQFPVEIRNLEPVTQLYVSVDA
STKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKGVTYCGESAASNLTMANVPWHEEVVHFVRELADLIPDYDIACEHEHSNCLLI
AHKKFKIDGEWCTWIDYDRFQELIQEYENSRGSKTFTAADYVAKTPHWAVFGSRERGFDP
LDTRFQRKNKTKDISGC
>A0A852A481|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Calcarius ornatus|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVTQFTTTRAKRKVTEPGTSDKLG
NGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEVINMEDYDPEDGLV
EETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTRLQAL
CRGEKKPCRGKCKKGKCKTSGKQSKESSDREHEMSEQDNTEAEESFETSSEEEAGGTDSV
IDVEDLGNIMGHMKKAKVLLLEGVNHSGYHLVYFMCQFLQVKPSCLMICALFSGYKLIGS
HSGVKLCRWTKVFLQVGSRWQWVTVPSSPRHHTNPVGTEWRWRMDQPQQILQEALEKHQN
MIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINQLVRLLHQQGISTFLVTNAQ
FPEEIRRLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLT
LVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVLSFVQELA
RLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYGRFQELVRERERSGGARTFTAAE
YTARTPPWALFGAKERGFDPQDVRFHRKNKAQDTSGC
>A0A7G9YD71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MTTFVVSNGTQPDMIAKISPTQLYLSLNAPDEETYLRVCNPHGNFWSEIQESLAVLGNSQ
SRSGSGSLIGAETGAGTRTAIRITLIKGLNMHDCAGYARLLRVANPDYIEVKAYMHVGFS
RKRLSRDAMPEHSEVLSFASEISDIIGYRVADDSRISRVVLLSRS
>A0A5B8MF79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chloropicon primus|TrEMBL
MAESEDIDGGNGGLFARIVSLWRKLLKLIKSIFKDEKWLSNLTLGLGLPTLSQLVRGQGG
GVVTSGKVFYGTQKGTSKRLAERLVHLAKKKFGLDLEAVNMADYEVEKLPTERGLVFFVI
STYTDGTPPEPAQWFYRWVEESAHDFRCGADFLKELKFAVFGCGNSQYVENFNKCAKTLS
GNLKLMGAKEVADVFLGDEDKGSLDTQFRDWTGILQLRLADYCKPLETLQLEKPRNPSVK
AKLEKIRKQKEKDGGQSTDIEDIGKALNGLKAGEKPEMLNHTTRGNLKKQGYKIIGTHSG
VKLCRWTKSMLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPIGKEWKW
KMDPPDKIVSEAIACHRGMIKEMKGVPGVKPERLAEGIDVKHCALSLVGEPIMYPEINEL
CNRLHGEGISTFLVTNAQFPRAIERLVPVTQLYVSVDAGNKESLKAIDRPLFSDFWERFL
LCLQKLRDKRQRTVYRLTLVNDWNVSEVEQYASLVDIGKPDFIEIKGVTYCGSNDASSLT
MKNVPYHNEVRAFGEKLCSLRNEEYGLACEHEHSLSILLARKDRYLKGRKWHTWIDYEKF
QSLYRSGKPFGAEDYMEETPSWAVWGAEEKGFDPQETRFRKKRNHPGKNVSVDSDTKQAI
KTT
>A0A2R6H4M6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_4_66_20|TrEMBL
MSDSESGPRQVDDPDYHSVNHTATQTCGWTKNALRGDGKCYKNIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQTELLSGFGGNDQVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTKPDVLDECDPTQLYVSVDA
PDRGTFDSTVKAVEDDAWERLIDTLDVLAAKDETRTVIRTTLVKGHNMHRPEWYAAMCDR
ADADYVELKAYMHVGHSRGRLDRDSMPDHEEVVAFAEEMREFLPHDELKQVPASRVALLA
RESETWIPKLQKSSDFWARDPLAE
>C5A4W5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)|TrEMBL
MRLMAIVVKANPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGI
ASHRCLQMTPVLAWCTHNCIFCWRPMESFLGTELPEPWDDPAFIVEESIKAQRKLLVGYK
GNPKVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLE
EMIKEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWERIMETLRLMRDAETRTVIRLTLV
KGENMHSPEKYAELIKIANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHL
PGYHIEDEYEPSRVVLIMRDDVNPKGRGLEGRFIKD
>A0A3M6KAZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVVEGEEQLIQIKPAISEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLNMLKHLNTRTVL
RVTLIRNYNDQDYMIPAFAKMFKEASPHFVEIKSYMHIGRSTNRLEHSNMLEMEEVKKFS
EQVAKQSQIFSIMDESFVSRISILQNNERFIDRWIPSYVNTN
>A0A842NX06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEIVDNDDDNLIQIRPSIVAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKF
YGISTHQCMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPEKVAEPEQIMTKLMAERKKLI
DGFYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKTLEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLDMLKHLDTRTV
LRITLIRNYNDQKEMIPAFGEMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMSEVKNF
SEQIAKESKIFSIMDESLVSRISILQNNERFIDRYIPTYSNTN
>A0A7D7Z614|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGETVEEEEALIQIRPAITAQLKKAKYGVADHSTVGLCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMNMDLEQVAEPADILTKLMAERKKLIN
GFYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPKLIKYLNSLEQTKSVFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFMKINKPRYDDSWERWNRTLGMLKDLDTRTVL
RITLIRDYNDQKESIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMDEVKQFS
NEIVKQSKIFSIMDESLVSRISVLQNNERLIDRFIPTYANTN
>A0A7K9NL45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Edolisoma coerulescens|TrEMBL
LDVSMDTWSYFHTCLVSVWLHRFYIYSAVAFGISLWIVIQFATTRTKRKVGEPGTADKLG
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVMNMGAYDPEDGLS
EETSSRNICVFLVATYSEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRKMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLTRLQAL
CKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEAGGTDSV
IDVEDLGDIMGHMKKAKVLLLEGLVYFVCQFLQPELNCLMIFALFSGYKLIGSHSGVKLC
RWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQ
PEVILQEAIENHQNMIKQFKGVSGVKAARLEEALRVKHCALSLVGEPIMYPQINRFVRLL
HQHGISTFLVTNAQFPDEIRRLEPVTQLYVSVDASTQESLRRIDRPLFKDFWQRFLDSLK
ALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANV
PWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKFQVEGEWRTWIDYGRFQELVRE
HERSGGARTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDVSGC
>A0A7S1NCE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eutreptiella gymnastica|TrEMBL
MVEWCKLLLPLSLLGGIPLCNFLVHLLRRITSGGDQSKAIGSRTSTDRGITILYATQKGT
AAQLAGRLAKRVEAKGVTPQVVDLAHYDPEDFPAEKFVAFIVATYEGGEGPVATHDFFRW
LEEHSNDFRVPKNAFESLNYSILGLGNSVYADKGHYNLVALNLDRSLQKLSGQRILEVSL
ADEQDGLLEVCDAWIEDLTQIVVQYGNGKALQPVRKAPSAAVVEDSEEDGSDDDGFEDDI
QSQGSNLMDMEDLGQAYGKKNKNAELLNPRLRQSLTKQGYQLIGSHSGVKLCRWTKAMLR
GRGGCYKHTFYGIKSYQCMEMTPSLACANKCVFCWRHHSNPVTKEWRWKMDDPEFLVTES
IDAHVRMINTMKGVPGVKPERLAEAYTPRHCALSLVGEPIIYPEINSFVRLLHERHISTF
MVTNAQFPDRIDQLDPVTQLYVSIDAATKESLKAVDRPIFDDFWERFLACIDSLRRKGQR
TVFRLTLVKDRNMEEMAEYCELVKRGQPDFIEVKGVTYCGENTASDLTIKNSPYHQEVVR
FCEELCDGANLAMGDTYGLACEHEHSVCVLIANKKFFVDGQWHTWIDYDRFHELALGNKA
FDATDYMEPTPGWAVFGADEKGFDPAEVRHVRKQKQKAST
>A0A7C0V0E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
RHSAVQICRWTKKSILGEGTCYKERFYGVHAHKCAQFSPLALWCNMNCVYCWRPMEWMRN
YNIGYDEVEDPDTIVRGVIEERKRLLIGFLGNPKASKERVMDALTPDHYAISLSGEPTMY
PRLAEMIRLIRDRYKARTVFLVTNGQVPEALSRLYEERSLPTQLYISVSASNREMCVRIQ
RPVLKDFWERLLKSLEIMREIEGSTRRVIRLTVIKGYNMDERFMPEFARLIELANPDFVE
VKAYMHLGLSTRRLSRDNMPRHEEVRAYSERLVNEYLRGFRIEDEQPESRIVLLRNEGST
VPTRIYPS
>L0AAT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldisphaera lagunensis (strain DSM 15908 / JCM 11604 / ANMR 0165 / IC-154)|TrEMBL
MEKVKMQDTYEALNEILKKQGYHLIGNHSSVKKCYWNHKAITENRFCYKSKFYGIESHRC
IQLSVSNHWCWNACTHCWRLRPQDVGLEWNETNMPYNDDPKFIVDNAIKEYRRIMSGYKG
RPGTDIKMYEEAMNPKHVAISLTGEATLYPRLGELIKEFHSRGISTFLVTRGIRPDILAN
LEEEPSQIYISLEAWDKDSYNLFNKPLVPRGWELTMETLEMLPSFSSTTVYRITVVKGFN
DSEEAINGFAKLIKLGMPNYVEVKAYMFVGASKGRLTRDNMPNYEEVKEVAQKLSKACGY
PIVSESKPSRVVLLSNMDKPIRYGNGMPMGWNSIEEESPGEYEEDEP
>A0A2T3ZLE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma asperellum CBS 433.97|TrEMBL
MDAGSRLQLGTAAADLVEVWHAYRTSIILCALVLLVGLRTLLHSTEEREPLAVLPQIYNQ
EKPEAKEKIALEAQPVAAAEKKSTGPRRIKGGVARKPSQEKKTTAIDYTDRPAKILVFFS
SVTTKTEKIAHEYIKTLEAFLDQKAGETESKFLKPELLDLTEIDFEDYFVSPPKSVENAA
YVYLFLLPSYNIDSINDTFLQHLQETHHDFRIDTAPLSPLIGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHVERFTEWATGVQDVISQAVQAGFLGEG
VPGSGDAVESDEEDAEADDGEVVFDDDEESGDGKSSDGSRPLDDVEDLGKMIRPNKNGNE
TTRKAPLAVDFTTYPSSGKKKAQAPIVKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRW
TKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPD
MIFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHN
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFLRCLDIL
REKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTATSSNAGLSM
SNVPFYWEVCEFVKALDKRLQEKGLDYGIAAEHAHSCCVLLASKRFNVNGKWHTHIDYQR
FFELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVTREAPE
>A0A7J9S5G5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVKKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYLDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A7J9NQH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFEAPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCLRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLDMGKILGENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A2Y9F8B2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Physeter macrocephalus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKQVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVAKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRSLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRK
NKSKDISGC
>F1NVK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gallus gallus|TrEMBL
MAGGLDVSMDTWNFVYACLVSLWLHRIYIYSVTAFGISLWIAVQFFTTKAKRKDEHSNGN
LVSSEVVEDKLVNGYATLQPKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVTCFNLPVEVI
SMGDYDPDDCLAEETTSKNICVFLVATYTDGKPTESAAWFCKWLEETSNDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFEA
WKSKFLNCLQALCRGEKKPCSGKCKKGKCKSQGKPSKESSNPERGAPEFENTETEELFET
TSEEEADAEEAGGTDSVVDVEDLGKIMSHMKKAKRERELEDGDAGMSLLGETSGRKEAGE
RREMITAALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREALENHRNMIKEFKGVTGVRAERL
EEAMTTKHCALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLYV
SVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADL
VSLGKPDFIEVKGVTYCGDSSASSLTMANVPWHEEVVHFVQELAQLLPDYGIACEHEHSN
CLLIAHKKFKINGHWCTWIDYERFQELVRAHVDSGGTQTFTATDYTARTPHWALFGSNQL
GFDPLDVRYQRRGKVRDISGC
>A0A2S4V9D2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia striiformis|TrEMBL
MFGLVESITNLIKPAAKPLKTQILYSSLSSTTKKLAEQLSTLLLTESEHLNSSIDTLDNL
DLDSLINQTPIDTVNQLIIFLLPSYNVESPVDSVLSQFRDALYDFRLDKNSLAGLSFFVI
GIGHSDYQNEFCKQAVELDSIIANLGARRIINLKKIDVSVDPEKDLSDYFQTVIRTTLSP
SLSSFAQLPPLSSSSEDDDNDEDENSDDEFKDYTSSKPLTKAEKARQKSSTKKKKSSAGT
TKEGTMDIEDLGTGIPQIEDLDIKDQDDEIIKKDMISPMTRKSLTKQGYAIVGSHSAVKT
CRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLACANKCTFCWRAHTNPVGTSWRWKTD
SAEYIIEESLKEHDRLIKQLSGMPGVRADRFTEARTPRHAALSLVGEPVMFPHIKKYISL
LTEKRISTFLVTNAQFPESLKDLPPVTQLYLSIDAGTKESLKSIDRPLHRDFWERFLESI
DIVHQKKNRTVFRLTIVKGENENQIKEYADLVRRGQPDFIEVKGVTYCGYPGSSNLTIKN
SPWHEEVKKFVEDLCEEINDPRYRTESSSGESKDGSTLEYGLAAEHAHSCCVLAAHSKYY
FDDKWHTWIDYDKFFELVEAGSTDFDGLDYCDITPDFALFNSAEAGFSPEDQRWFRKKTL
AAQKEKLDQLNQDHQKEDDQNILPPPIGPSQ
>A0A1W5D0B6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lasallia pustulata|TrEMBL
MLADTFDIVELTQIWHEYRILILGGLLNGMSLAWIMLVWLPRWWRRRERLSSSPNAGSPS
LAPAAIERNPVLNDKGASIAAEDKQHETRTQTTTESVAKDVEKTASRPRLGPKRVTRTIP
RKPTRTTGGQSEDERITQQTKVQPLVFFSSLTGSTERYATEFANSFRLQSDAVSDTTVLD
PQLHDLSYIDYDEFFITPPRSNGPTDRIQYFYLLLVPTYNIDTVLNTFLAHLQETHHDFR
IDTGSMSGLLGYSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAFPLGMGDVKS
DALARLEEWGSGVKEVLNDLIINGGLGEGVSGSGDAVESDDEDLETAEANALKPGNPMLK
KSRLSKSNRTANVDDLEDLGDKVPSNNSSANDPATSTTPLAIDFTTSSCTSQPPAATQSL
KEMVPITSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMET
TPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPDLIFNGVKEGHYRKIKMLRGVPGVRAER
FAEAMRIRHCALSLVGEPIFYPHINDFTALLHRERISSFVVCNAQHPAQLAALRPVTQLY
VSIDASNRESLRRIDRPLHRDFWERFQACLDVLREKRGVQRTVFRLTLVKGFNVDEEVEG
YAGLVERGLPCFVEVKGVTYCGTSDSKGAGLTMQNVPFWEEVEAFVVALSAALARRGLDY
GLAAEHRHSCCVLIASKRFLIQGKWHTTIGYDKFFECLESGREFGPEDYVGDPTPEWALW
GKGGFDPADERVYRKGKNRQGGGGXGEGRVLEL
>A0A5J5F061|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaerosporella brunnea|TrEMBL
MAFDTEEPGAQALEKLLAFLRVSDVIELWHECRAAIFVAVAVVIIFKFQKWLQGEKASAE
TAQPLDSVTISGKATPEPKENAQDLAETLKPTLKPTLKPALKPTPKASSTSPKSGPKVIS
GHKKKLVKKGKKLRQAPAPQDEEEDDFDIQIYIFYTSLTGSTAQYAEQLKNQLLSDKEGI
YPKFSVPTPSNFLPEVPISRTFLPPQIHNLEEIELDDYFVSAPSATSKAGKKVKYIYLVI
APSYEADSPNAAFLYHLQETHNDFRIDTAPLRSLAGFSVFGFGDSSEWPESEGKFCQDAV
AIDKWLGKLTGGRAGSRRMFPVGMGDVNPVSTKECKESGNAIEKLHEWRIHLEDAMREYA
ETGELGGGSEWRAGVESGDEDSDVDVEEEPEKDMMDLEDLGGMINRAPDVLKKTSTSCSA
PLPVDFTTPAGKIALAAGEGQSASRKDMVPKDGVTYKALTKQGYEIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEAI
FRGVVEGHYRKIKMLKGVPGVRADRFSEAFRIRHCALSLVGEPIFYPYINEFLALLHGDG
ISSFLVCNAQHPAQLRALGPVTQLYVSIDASNKESLKKIDRPLHRDYWERFQECLDILRE
KRHKQRTVFRLTLVKGFNVEDEVKGYADLVERGLPCFVEIKGVTFCGTSSAGEAGLTMDN
VPFYEEVVEFVEALNAELERRGLEYGIGAEHAHSCCVLLASKRFFIDGKWHTLIHYERFF
ELLKEGREFGPEEYIGEPTPEWANWGNGGFDPSDERVYRKGKGPDGRAKAKEAAVARRME
KEAEITVSAW
>A0A3M7AK33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MPIAPGECTAAHVATNIHPPPMMDMEKILQLPEELLFLWHAHRAEVLLSAGLLFALLRLA
VHWRTRKSKEVLTPPVLTPVDEKPLAVPSAKETLADADHYEAPTPKPAVQRPKPGPKRVT
GTKKSKSAASQEAQVIEKIQPIIFYYTLGGSTKVYAESVAQDLTTSSPSPILEPQLHDLA
DTEYDDFFLSIPKAEKTAHFYLLLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSKLAG
YSVFGLGDKHEWPSEAEGFCTQAVDADKWMARLTGRKRGFPLGFGDVSKKDEADVMLKEW
TEGVSSIMKDLAEGKGLGEGVPGSGEPIESADEASEDEDETPAPRKSKRKPAKRSKTDDL
EDLKAPIPVDFTTSKPTSTTQPPPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPV
FQGMKEGHYKKIKMMRGVPGVRAERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRER
ISSFLVCNAQHPDQLEALGPVTQLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGR
KRFTHRTVFRLTLVKGFNIEEEAEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQN
VPFYQEVTAFVLALEKALAKRGLDYGIGAEHAHSCCILLADRERFYRIPEAEKDNPAAER
KWHTLIDYPRFFDCLESGKPFSPEDYVGPPTPEWALWGNGGFDPRDERVDRKGRPKEVKV
QEVQE
>A0A7J8F044|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rousettus aegyptiacus|TrEMBL
MDPPLATWDFSPLISLWINRFYIYLGFAFGISLWICFQIAIRKQDKNSQEKSVPKTTQDL
MTNSYISLQKKEIFVSGVKIFYGSQTGTAKGFATVLAEAITSLDLPVAVIDLKEYDPDDH
LVEEVTSKSICAFLVATYTDGRPTESAEWFCQWLKEASTDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRIMTRGEGDCDVVKSKQGNIEADFRAWKTKFISQLQ
ILRKGEKKPCDGNCKKGKCKSNEHISEEIETGSHAQDGLHQRDTEEEEPFESTSEEEPDT
EDHQSLSSVVDVEDLGKIMNRVKKEKREMEHKEEKTGLFRNTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKLMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPDINRFLKLLHEHKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKSWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVHFVYELVDLIPDYEIACEHEHSNCLLIAHKKFKI
DKEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMAKTPHWALFGASERGFDPKDMRYQR
KNKSKDISGC
>A0A7K9DZI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Baryphthengus martii|TrEMBL
MDTWNFYTGLVSLWLHRFYIYSAVAFGISLWIIIQFTTTKTKKKVTEHGKKSNGNPAAPE
GTEDKLANGCATLQAKEIYVAGVKIFYGSQTGTAKRFAKGLAEAITSLNLPVEVVSMGDY
DPEDCLSEETPSRTICVFLVATYTDGQPTESAAWFCKWLEEAAHDFRYGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNVDRWLWALGATRIMTRAEGDCNVAQSKFGSIEADFEAWKAKF
LSRLQALCRGEKKPCSGKCKKRKCKSPGKQSKESSDRERGTSEYEKAEAEELFETSSDEE
AGAEEAGGTNSVVDVEDLGNIMSHTKKAKLGLGTRRILYTVRFVFPELQSFQEMHLNPPL
ASEGVSSYCYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEVILQEAIGNHQNMIKQFKGVSGVKADRLEEAMAVKH
CALSLVGEPIMYPEINRFVRLLHQHSISSFLVTNAQFPDEIRSLEPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDF
IEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKK
FKINGEWCTWINYDRFQELVREHEASGGSKTFTAADYTARTPRWALFGSRERGFDPLDVR
YQRKNKARDISGC
>A0A8D0C4J0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salvator merianae|TrEMBL
MEMAGETWDGLRAPLAFLWLNRFYLYSCLAXGISLWVFSQFLTKVKKQNGSSFRSXPERA
AEKXAKXEGSPAFDKVNVAGVKVFYGSQTGTAKRFAWSLFDAVSSLDLPGEVIDMKDYDP
EDSLADEASSKNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVAKTYLKGFNYAVFG
LGNSSYADHYNTVGRNVDKWLWMLGAQRVLSCAKGDANVVKSKHGSIEGDFEAWKAKFLS
RLQALLRGERKVCSRKCKKGRCESKRKXGQEMLEQQQRAPEGEEEEHQQELVETTSEEEE
SGSEDGGRPSSLVDVEDLGRVMEHAKKAQRKQERGTEVGRMGGXSPEQKREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCLETTPSLACANKXVFC
WRHHTNPVGTEWRWKMDPPEMILEEAIENHQSLIRQFKGVPGVRGDRFEEAMDARHCALS
LVGEPIMYPEINQFLRLLHRRHISSXLVTNAQFPEEIRNLGPVTQLYVSVDASTKESLKR
IDRPLFKDFWQRFLDSLHALAEKPQRTVFRLTLVKAWNVEERKAYAELVCLGKPDFIEVK
GVTYCGESSASNLTMANIPWHEEVVHFVQELVDLLPEYEIACEHEHSNCLLVAHRKFKID
GRWHTWIDYERFQDLVRRYEESGGVKGFTSTDYLAPTPVWAAFGAKERGFDPLDTRYQRK
NKTKDISGC
>A0A328Q4P5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera stadtmanae|TrEMBL
MIISQTKQKDLEKKGYRFAGKNIHAANKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PAIAYCQHKCLFCWRDTDITKTSWDSDDYDDPKTIIEDCIENQKKLLCGFFGNENANPEK
LEECVKPNNAALSLAGEPLLYPEINQLIEEFHKQNFTTFLVSNGENPDKIEALGKHEPTQ
LYISLDAPNKEIYKKVCKPQVSNGWEKLQESLELLSTIDTRKVLRITSVKDLNMIHTEEY
AKIIEKADIDYVEIKAYMFVGDSRNRLQWENMPKTVDIQEFAQSIAEKTSMNIIDEVEKS
RVLLLGEKKPGKYNN
>A0A7K3YKK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crenarchaeota archaeon|TrEMBL
MDKVSDSSLFTSLKKQKYHLIGAHSAVKRCKWLYEAIVNNRPCYKQKFYGIQSHRCIQMT
PSLYYCTQQCLFCWRAQSGDMETQWDEMRNPNKDTPEQIIEGCLKAQEKIISGYKGNEKT
NWKKFFEAQQPSQVAISLTGEPTLYEPLGDLIKSFHKRGLTTFLVTNGTLPSKLSRLSQE
PSQLYVSLCAPNEDIYKKVCRPQFPNAWIKLNQTLDMLQSFNCPTAVRMTMVKNHNLGLI
NEYAKLIEKSNPTYIEVKAYMHIGFSNLRLSFGHMPMHQEVRDFANILAENTGYKVINEA
PESRVILLSRLEKPIQLGRNT
>A0A8J6DC26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium anomalum|TrEMBL
MTPSSLSTRLTLFALLSVTTFYFLYKSRRCRVKPLKHLPLNPNPRPGKLFFLTQTGTSEA
LAQRLLDLLSSKNNIPFDLVDPQTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVCESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDAKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQMKGVPGNFHKFGEFTRPIVAGVTQERLMEGLSPRHCALSLVGEPIMYPE
INALVDELHRRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFW
ERFMDSLKALKEKHQRTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSAT
SKLTMENVPWHSDVRAFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWID
YEKFHDLVASGRLFDSEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A7K4IID1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaerales archaeon|TrEMBL
MAYPPLLLDVLRRQKYHLVGRHSSVKKCKWLHDSLVYNRVCYKEKFYGIRSHRCLQMTPA
VLSCLTHCIYCWRAMPEDVGMKWNETLRFDWDEPEEIIHGCLREQSRILTGYKDQVIKRI
VSKEKYEEALNPNMVAISLSGEPTLYPRLGEMIELFREKGFTVFLVTSGVLPKALERLDS
EPSQLYISVTAPDYDSYQKINRPVSQRLWDSLMKSLEVTKSFKCPVVMRITAIKGINMHD
PENFSRLVSLSDCSYVEIKAYMHLGYSINRLARSNMPSFDDIKRFGDRVSELTGYNTTGS
SEESRVVLLSKLKKPIRFDRSA
>A0A6C1EID3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces pastorianus|TrEMBL
MDGFSLAGAVSVGTLIAAYLYFGGRFSIALVILVGYGIYCNEAGGQVEEKVISSPEKKKS
CCSDKKNADGEKTGGCCSEKKKNGAGGGGCCSSKDGKKKSGGGCCSSKDGKKGKGGGCCS
SKKKTSNDENENVDVVPQVQESKNFPVTVDFTDVFKKPAKKRSGTPKVFSKNNSSKSKIG
KKLSVSKKIGQDGLIKTALTISNETLLSSQIYVLYSSLQGAASKAATTVFDKLTGLYELV
NKPKLLNLDDLSDFDDYFVDVPAENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSF
PLRKLVGYTVLGLGDSESWPEKFCYQAKRADYWISRLGGRRIFPLGEICMKTSGNTKIEE
WTSLLAETLKDDEPIIYEYDENADSEEDEGEEDNGSDELGDVEDIGGKDNNGKFSSADEI
KQMVAKDSPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMEL
TPSLACSSKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAER
FAKAFEVRHCALSLVGEPILYPHINKFVQLLHQKGITSFLVCNAQHPEALRNIVKVTQLY
VSIDAPTKTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAY
ADLVQRGSPCFIEVKGATFSGSSDGNGNPLTMQNIPFYEECIKFVKAFTAELQRRGLYYD
IAAEHAHSNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGN
GGFAPGNVRVYRKDKKNQNKENQDKSSSSSYSSSNNNIY
>A0A075LVY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Palaeococcus pacificus DY20341|TrEMBL
MSDARYNMPEEIANLFKKQHYALVGRHSGVKLCHWLKESIKHNRVCYKQKFYGIQSHRCL
QMTPVLAWCTHNCIFCWRPMEGFLGIELPEPWDDPAALIDESIKAQRKLLSGYGGIKDQI
NARKLDEAMEPKHAAISLSGEPMLYPKIGELVEEFHKRGITTFIVTNGTEPERLEEMIKE
NKLPTQFYVSLTAPDEETYNKVNVPMIPDGWEKINKTLELMNGLPTRTVIRLTLVKGENM
HNPEGYAELIMKARPMFVEAKAYMFVGYSRNRLTINNMPKHAEIKAFAEELVKHLPGYHI
EDEYEPSRVVLIMRDDISKEERFIKL
>A0A0W0CJ88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida glabrata|TrEMBL
MDSTELTIGGLLVVGSAIYLTFFSGRITVLLVAVVGFCIFVNERHNHASSNTGASEIAAT
LSEKTVEEVLPLPKKKKCCGGGVGGKCCSETKKEGDHSDGGSCCSSKKKLVEPLLQKLKE
EKPASTTEEPSYPISVDFTEAFKSTSKKSKKVPKIIVGVNKKKESEEDIVKSALTVSNEK
LLSSQIYVFYSSLQGAAERVARTVYEDLKNVKDLNNEPILMNLDELNDIDEYFVDVPVDN
ALYILVVPSYDTDCPLDYFLQTLEENYHDHRVDRLPLKKLMGYAVLGIGDKESWPDKFCY
QAINVDHWIAKLGGRRIFPVGEVCMKTDGMQGVDKWTNLLADTLEDDEPIIYQYDNDAES
DYEEDEEQIDFDSDTDVQDVEDIGGKQQSKGDYGMEVKQMVAKNSPTYNNLTKQGYRIIG
SHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCWRHGTNPVSK
NWRWDVDEPEYILENALQNHYSMIKQLRGVPGVIAERFADAFKVRHCALSLVGEPILYPY
INRFVELLHQNDITSFLVCNAQHPEPLRNIGKVTQLYVSIDAPTKQELKKVDRPLYKDFW
ERMLECLDILREVQYHQRTVFRLTLVKGFNMGDITSYADLVARGLPCFIEVKGATFSGSS
DGNGNPLTMQNIPFYEECVNFVKEFTKELQRRGLGYEVAAEHAHSNCILIANTKFKVNGE
WYTHIDFDKFFSLLKDTERKEQFTYMDYMAKTPEWALFGNGGFAPGNVREIRKEKKKKNR
EEREKALKEAQAALEVQQDA
>A0A673BZU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
MLNLLVLSVSHSAQSPALSYITSIWHNRLYLYSAAAVFVGIWISLKMGLKKQSLSADTAP
KVYKAEKKNGCSDRDAVVHVSGVKIFFGSQTGTAKGFAKQLSEEVQTLGLTCEVIDMKEY
DPDDRLADECTSRSVCVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYAV
FGLGNSVYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVKF
LNRLQNLVKGDKKSCSGNCKNGGSCKNKRKDGHGQEEEEDEDLMESSSDEDESGLQEGKK
SVVDMEDLGDIMTSVKKAKVKKEKEEEELSKLNGVKKVEDEGERREMITPALREALTKQG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDPPEKILQDSLEKHENMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEP
IMYPEINTFLRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPL
FKDFWPRFQDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYC
GESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWT
WIDYERFQELVQVHEDSGGQQSFSALDYVAKTPRWALFGAEEQGFDPNDTRFQRRNKTKD
ISGC
>A0A8B9ZJM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anas platyrhynchos|TrEMBL
MFFFVFSQGEKSNGNLSSEVVEEKQANGYAALQAKEVYVAGVKIFYGSQTGTARRFAKGL
AEAVISLNLPVEVISMGDYDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEE
TANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNV
AQSKHGSIEADFEAWKTKFLSCLQALCRGERKPCSGKCKKGKCKSQGKQSKESSDHEHGA
SEYENAELVETTSEEEADAEEVGGTNSVIDVEDLGNVMSHMKKAKLFIIDSNIAEIDHLI
YLLSSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVAGVKADRFEEAMTAKHCAL
SLVGEPIMYPEINRFLKLLHQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQ
RFLDSLKALSEKQQRTVYRLTLVKAWNVDELRAYADLVSLGKPDFIEVKVSCTSASSLTM
ANVPWHEEVVRFVQELVELIPDYEIACEHEHSNCLLIAHKKFKVDGEWCTWINYERFQEL
VREHERSGGSKTFTAADYTARTPHWALFGSSQRGFDPLDVRYQRKSKAKDISGC
>V7CRL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaseolus vulgaris|TrEMBL
MAIARLVRQAKRPHGLWVKMAAVTVLGLCFIFVWGVFSSSSSSVTSQRESFEDIAEPVSS
SSHKPQKLRDDSKKGGGSEKKSKSNGNGSSHSSATRPHSEQHKGKDSKKEKKHVHEEDKE
KGNHQGLEDPQPQHVEEKEKEKENEKEEVEVEGEEEKVDHESEVDVDADGGSDLAESVDK
DGSEVVEDVEELRKKSKGKITGPLFDPNASYSWKLCSTRSKHNYIPCIDIEVGGGKVTSY
RHTERSCPRTPLMCLVPLPHEGYGFPLPWPESKLKILYKNVAHPKLAAYIKRHSWLMESE
EYLTFPQNQSEFKGGIHHYLESIEEMVPDIEWGKNIRVVLDIGCTDSSFAAALLDKEVLT
LSLGLKNDLVDVAQVALERGFPAVISPFNRRRLPFPSQVFDAIHCAGCSIPWHTNGGKLL
LEMNRILRPGGYFIMSTKHDSIEEEEAMTTLTASICWNVLAHKSDDVGEVGVKIYQKPEG
NDIYQLRRKKIPPLCKENENPDAVWYVPMKTCLHPIPSGIEQHGAEWPEEWPARLETYPD
WVNNKEKVVADTNHWNAVVNKSYISGLGINWTSIRNVMDMKSIYGGLAVALSQQKVWVMN
VVPVHAPDTLPIIFERGLIGIYHDWCESFGTYPRTYDLLHADHLFSRLKNRCKQPVSIVV
EMDRILRPGGWTIIRDKVEILNPLEEILKSMQWEIRMTFAQDKEETGTCKTLALRLHRLL
ASNGVAFDVVDSRHYEPEDLPKETLLLLVASTWQDGAPPAASRFFATWLAEAAADFRAGS
LLLSSCRVAVFGVGSRAYGESFNAVAKGLATHLRALGAKEVVPLCEGDVDGGDLDEVFDR
WCEKVVAVLKGGGVAECDDDDSGGAVESVYSSSEEESDVESEIVDLEDIAGKAPSRRKTV
ANGEESNGKLNGRKEMVTPVIRANLEKQGYKIIGSHSGVKICRWTKAQLRGRGGCYKHSF
YGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIEIVNSAIDLHKNMVKQ
MKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINALVDELHKRRISTFLVTNAQFPEK
IKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALREKHQRTVYRLTLVKG
WNTEDVDAYSKLFSIGDPDFVEIKGVTYCGSSTTSKLTMENVPWHTDVKAFSEALALKSQ
GEYEVACEHAHSCCVLLAKTNKFKIDGQWYTWIDYEKFHDLVASGKTFDSSDYMTVTPSW
AIYGSDEGGFDPRQLRYRKERHHKSSRKQ
>A0A7N6BSW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anabas testudineus|TrEMBL
LLDPQDVHSSSYFMSIWHNRLYLYTAAALFFGIWFALKISLKKVNVNSSVNKTEKSSERS
DKQKVVHVSGVKIFYGSQTGTAKAFANELSEEVKALGIPAEVTDMKEYDPDDQLADECTR
KSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYFGHY
NTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSVQADFLAWKVKFLKRLQALAKGEK
KKCSGNCKKGGSCKNKRKDRKVEEEGEKDLMETSSDEEGSGLEDEKKTGSVVDMEDLGNI
MNSVKKAKVRLILYYHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWRWKMDPADKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLEVKH
CALSLVGEPIMYPEINAFIRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKE
SLRKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAVGQPDF
IEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPQYEIACEHEHSNCLLIAHTK
FKVDGEWWTWINYEHFQELVQAYEESGGQQSFSALDYIAKTPSWALFGASEQGFDPADTR
FQRRNKTKDITGC
>A0A8K0Y5U9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotalea sp. TS|TrEMBL
MSCSGETVEANNEFIQIKPVILNQLKKAKYGVSDHSTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMQPERVAPPEIILSNLMEERERLIM
GHYGDVKSDKKKIDESLLPSHYAISLSGEPTMYPQLPELIKYLKQLPATKSVFLVTNGQE
PEMLERLQDEDALPTQLYLSTNAPNEEVFQLVNRPKYKDAWERWNASLEILSEMDTRTVL
RVTLIRGLQ
>Q6C3V9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Yarrowia lipolytica (strain CLIB 122 / E 150)|TrEMBL
MFDEILDLWHGSRLMLIPIIGLVIFIVLFDEKKPVEAENETVEKSAATTTTNTSSRALDE
KPPMAVDFTTSSSVVSSKPKRVPKTFGKGPKKLSVSLSSQVYVFYSTLTGSTERYAQQLF
EYLSTQTKKEPILLNVDYIDDLDEYFVSSKAGSVYCFIVPSYETESPLDYFLDAIKETYN
DFRIDSRPLSKVCFSVFGVGDKESWPEKFCYQAKEVDRGLAKLGARRLNPLGNGCVKTDF
ETNMVEWREHFVDALADGVVPEADDICSDDEEEEEDSKDGIVDVEDMGKIIGSSKPKRKS
AKDIMEADSCSAKEMVAKDSPTYKALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFA
FYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPKEIIDGALAGHYQKIK
MLRGVPGVSAERFAEAFRVKHCALSLVGEPIFYPHINEFVGMLHEKRISSFLVCNAQHPK
ELAAMNQVTQLYVSIDAATKESLKAVDRPLNRDFWERLQECLSILREKRNQRTVFRLTLV
KGFNAEEVENYAKMVAKAMPCFIEVKGMTYCGTSKGNPLTMKNVPYYHEVLDFVEQLNEA
VANEGLEYGIAAEHAHSCCVLIAQKRFYIDGEWHTHINYDKFFDMLEAGQEFGPEDYTSA
TPHWAQYGAEEAGFNPADVRHRRGKVVEV
>A0A1S2Y4A7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cicer arietinum|TrEMBL
MSSFSSVSARLTLLAIFSATTFYCLYKSRRLRNLKLKLSLNPNPKPILPKILFISETGTS
KSLANRLHRFLALNDVAFDLIDGRSYEPEDLSKETLILIVASTWEDGKPSPAYRFFADWL
AESAEDFRVGSLLLSRCRFAVFGVGSRGYGEAFNAVGKDIVKRMKALGAAEMIPLWEGDV
DGGEVDEVFDRWCGKVVGLLKGDGGGDDQNGDLENGDEECGVLSSEEESDLEEEVEEEIV
DLEDIAGKAPSRKSGATVEETNGKLNGKKEMVTPVIRANLVKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWQWKMDDPIE
IVNSALDQHTNMIKQMKGVPGVTLERLTEGFTPRHCALSLVGEPIMYPEINALVDELHKR
RISTFLVTNAQFPEKIKSLKPITQLYVSVDAGTKDSLKAIDRPLFGDFWERFIDSLTALK
EKHQRTVYRLTLVKGWNTEDVDAYFKLFSIGEPDFIEIKGVTYCGSTATSKLTMENVPWH
ADVKAFSEALSLKSQGEYEVACEHVHSCCVLLAKTKKFKIDGQWYTWIDYEKFHDLVASG
STFDSKDYMAATPSWAIYGAEEGGFDPAQLRFRKERHHKSGRKESG
>A0A8J8JYJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanopyri archaeon|TrEMBL
MADGVVSVLRGQGYALVGRHSAVKPCHWCREAIKEGRHCYKARFYGVESHRCLQMTPAVA
WCQQRCVYCWRPVEKTVGVSDVPDPDDPGEIVEGSVEAHRRLLQGYGHLEGEAGRRWRES
LEPRHAAISLAGEPTLYPRIGELIEEFHKRGFKTTFLVTNGLRPDRLESLDEEPRQLYVS
LDAPDESLHRRINRPVVPDSWDRILETLELLPSMSCRTVIRITAVKGWNMEGTAEGFARL
VELAEPTFVEVKGFMAIGWAAFRMGPENMPEHGEVVGFARELAEACGYELVDESPPSRVA
LLA
>A0A8C7BSH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neovison vison|TrEMBL
MDPAGAWDSASPWVSLWTNRFYVYVGLACGISLWICFQMVVRRRDKSSQERSVPKASQDL
GTDGSISLQRKEVSVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVVDLKDYDPDDH
LVEEVTGKNVCAFVVATYTGGRPPHSAQWFYRWLEEAAGDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWTLGAHRVVARGEGDCDVANSTHGSIEADFRAWKARFLARLH
TLEKGEKKPCAGSCKRGQCESSAEEEPFESTSEDESGAEDRPNPNPVVDVEDLGRIVSCA
KREKREKEQPEEKSGLLRSSGKNGPGERRAMITPALREALTRQGYQLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEV
ILKESIENHQSMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLTLLHEC
KISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALA
AKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWH
EEVVHFVQDLVDLIPDYEIACEHEHSNCLLIAHKRFKVGSEWWTWIDYDRFQELVREYEH
SGGSATFGAQDYMARTPPWAVFGARERGFDPKDTRYQRKNKSKDISGC
>A0A672LQ32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus grahami|TrEMBL
SKLYSRAFTGALNDVWEFTESYLLTVWQNRLYVYTTAAVLIGVWLTVNMLFKKKKMVDPI
SPLLYKSVKNQELSPETEKVLYVSGVKVLYGSQTGTAKGFAKELAGGISAQGIQCEVIDM
KEYDPEDRLAEECTSKMVCVFLVATYTDGQPTESTEWFCKWLEEASTDFRYGKTFLKGMR
YAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFHAWK
TKFLNRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSEEELMESSSDA
ESSAEEEKSRGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNGVRKSESEEERR
EMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPS
LACANKCVFCVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVT
NAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVY
RLTLVKAWNVDELKAYADLISLGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQ
QLANLLPDYEIACEHEHSNCLLLAHHKFKVDGKWWTWIDYERFQELIQEYEESGGTKSFS
AMDYMSKTPSWAIFGAGERGFDPLDTRFQRKNKTKDISGC
>C3NDY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A150GHI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gonium pectorale|TrEMBL
MDVLALLVATVKTSWLLGLAALFLYIWRSAGSPNANKRKPAVASRDASGQVKQDVSQDDA
AKEQKGCCGGGQAGNTGAQARAAACACKAAADSNSPAASTALPPIVRVLYGSTKGTCRQL
ASDLAQRLDAALAAASAAAVPGGSSGACCGGKAAGAASETAACCGGAGGGTAGAAAPAAA
SAPRVAPTDLSAYEPEGLLSEPAGSLVVVLVSTYEGGTPPENARFFCSWLEDAASDFRLG
SAALSHLRVAVWGAGNSLYEQHFNAVARRVDTQLRALGASSELPLGLGDEDAGDMRAQFA
TWRDGLVAAATGAPAAASTMPNGRPAEGAGEEQEEEDDEYEVEDEDDEEEGGGSEIDMED
IGGTGPRRGKKHAGSAATSVSGAAGGDGRPEMLNPLIRGSLTKQGYKLIGSHSGVKMCRW
TKSMLRGRGGCYKHAFYGIASHRCMEATPSLACANKCVFCWRHHSNPVGKTWKWAMDPPD
VIVDTALELHTRMVREYAGVPGVKPEAVAEGLQAAGLSVCVAG
>A0A0D6R5Z5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Araucaria cunninghamii|TrEMBL
MEATQSMCTAAGGSSLAARVALAALVSASLYCLWKSTRLKTTKSLTNHQKQEEKLQKPNP
QPCCRSKVRNPATQPNGCCKSSSTPKQENLNSGCCGGGESTGKIFFASQTGTSKTLAHRL
SKLLEENSIKVEVIDPRSYEPEDLAKESLVIIIASTWQDGRAPDNAEFLAQWLDESSKDF
RVGSGLLSKCKFAVFGVGSRSYGATYNLVARAFFRQLTGLGGLALLPAGEGDQDDGNLDG
NFNAWRRRLVESLLSEKPVGGENNLAEDGFSDYCSGGDSEEDKDNDASGDAIVDLEDIAG
KVSFTAAKNGFSRKQFGKVNKVSKDFSGEKPPSLEENGPRAMVTPVIRASLEKQGYKIIG
SHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGK
SWRWKLDDPLQIVEDAIDQHTKMIKQMKGVPGVTQERLTEGLTPRHCALSLVGEPIMYPE
INTLIGELHRRQISTFLVTNAQFPEAIKSLTPVTQLYISVDAATKERLKAIDRPLFGDFW
ERFIDSLKALRDKQQRTVYRLTLVKGWNTEELDAYTELFELGKPDFVEIKGVTYCGSSAT
STLTMENVPWHADVKVFSEALVARSNGEYELACEHAHSCCVLLANASKFKVQGQWFTWID
YDMFHQLAASGEAFSSKDYAAPTPSWAVYGATEGGFDPGQARFKKERRHGAPPTHS
>A0A7J2IVN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPGIPEELIRLLRKQGYHLVGRHSAVKRCHWLYASLTSGRFCYKQRFYGIASHRCVQMTP
ALFYCTQRCLFCWRVQSGDQGLSWAETKMPEWDDPELIVEGSIRAQRQILSGYKANPKVE
PRKLEEALHPRHAAISLAGEPTLYPELGALIAEYHRRGFTTFLVTNGTLPERLASLDEEP
TQLYVSLVAPNERIYKALCRPQLPGLWDKLMETLELLPSLSCRKVIRITLVKGWNMCDEP
SYARLIEKAEPDFVEPKAFMWIGFSRLRGLKYENMPKHNEVRAFAERLASELGYNVVDES
IPSRVVLISRYEKRWPIGKPRPSTS
>A0A7J2LBX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MIPEEVAKILRKEKYAIVGRHSAVKKCRWLHESLVNNRYCYKQKFYGIKSHRCLQMTPAV
IYCTHQCLYCWRVQKGDIGLDWEMPSEWDEPEIIVEESIKAQRQILSGYKAHKKVPYEKY
LEAIEPKHAAISLSGEPTLYPYLGELIEEFHRKGMSTFLVTNGTQPQRLAEITQPSQLYI
SLSAPDIETYKAICRPLSPKLWNRIMESIELIQSFTCPTVVRITAVKGLNMKKPEKYAKI
ILKGNPTYVEVKAYMYVGLSRQRLKFENMPTHEEVKRFATQLAEELSYDIIDESEPSRVV
LLSRLKKPIKIGKE
>A0A7J3JC05|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSPLLASLKKQKYHLIGVHSAVKRCKWLYESIVNNRVCYKQKFYGIQSHRCIQMTPSLYY
CTQHCLFCWRAQSGDMQVTWDEMRNPNKDTPEQIVEGCFKAQEKIISGYKGNEKTDWRKF
QEALRPKQVAISLTGEPTLYEPLGDLIGLFHQKGLTTFLVTNGNLPSKLSKLSQEPTQLY
VSLCAPNEDVYNKVCRPQFPKAWKNLNESLELLKSFRCPTVTRMTLVKDHNMNEVDGYAK
LIEKAQPTYIEAKAYMHIGFSGLRLGFDHMPLHGEVREFAEKLAEASGYRVIDEAPESRV
VLLSRLKKPIKVGSN
>A0A7L1XX11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thinocorus orbignyianus|TrEMBL
LDASMDTWNFFYTCLMSLWLHRFYIYSAVASGVSIWIVIRFFTTKTKKKVTEPIRFGNPA
TSEGTDDKLVNGYGTLQAKDVYVTGVKIFYGSQTGTAKKFAAGLAEAIISLNLPVEVISM
GDYDPDDCLADETTSRSICVFLVATYMDGQPTESAAWFCKWLGEAASDFRFGKTYLKGLR
YAVFGLGNSVYVDHYNTVGRSVDRWLWMLGASRILTCAEGDCNVAQSKHGSIEADFKAWK
TKLLSRLQALCRGEKKPCSGKCKKGKCKSSRKRNKESSDHEHGASEYENTEAEELLETSS
EEEADAEEAGGTNTVVDVEDLGNIMSHVKKAKQFWRSSIGMVTFNNCVYQLVGFVYQLLQ
VKNFGLIYFLFPGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAVDNHQNMIKQFKGVSGVRADRLEEAM
AVKHCALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STRESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELIALG
KPDFVEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLI
AHKKFKVDGEWWTWIDYDRFQELVQEQERSGGSKTFTATDYVAKTPPWALFGSRERGFDP
LDVRYQRKSKARDISGC
>A0A3R7D4R6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MDVPETFRTVLMKQGYRLVGKHSGVKVCEWTRRSLTRGEYCYKQKWYGIESHRCLQCSLA
LFWCLNRCLYCWRSFKLFLGAEMKVEPDDPEWILEGLIEAQRTLLVGYKGNPKVPRWKWE
EAQNPTNLAISLIGESVLYPRLPEFIAVAKERGMNTFLVTKGTYPEMLRKLEVEPTNLYI
SLCAPDKDTFERLDRPIIPDGWEKQMESLELMRSFNCRKVIRITLVKGYNMHGIDGYARL
IAKAEPDYIEPKAYMWVGESRKRLPGEAMPTHEDVIEFAEKLAEETGYKFADFFRPSRVA
LLSAK
>A0A834SC12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora tritici-repentis|TrEMBL
MVFLQYAEQLPGELLLIWREHRLEILLSALIVATIARLVIYSRDRRREKLSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLPNVDNHAEDDTAAVRVVSKAKKGPKTVKGRKTQKKNT
APISTFDHKVHKIQPLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQIHDISY
IEHDDFFISPPKADANVKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GVQEALVEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSVVNSSS
APIPVDFTTYKKSAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINDLLSIMHSHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNARGLQYGS
>A0A804IZV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Musa acuminata subsp. malaccensis|TrEMBL
MAKTPLDPPLSSSRLALVALLSATSVFFLWKSRRRLRVLLSPYSSMNTPKPSPRGKIIYA
SATGTSRSLAGRLSDCLRSHGLAFDLVDPRHYEPEDLPKEALVLIVASTWEEGRPPADAQ
FLARWLAESAADFRVGSLLLAKCRFAVFGVGSKSYGDSFNAAAKDFSKWMRALGASEMAP
VWEGDVDSGDVDEVFEVWSRRIVALLKGEDLKKESGHSGSMVESVGFDESDEEVEEEVLE
PVVVDMEDIAGKAPSRRPSVALTNGWENGVKDMVTPVIRVNLEKQGYKIIGSHSGVKLCR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDNP
LEIVDVAIDEHTKMIKQMKGVPGVKPERLSEGLSPRHCALSLVGEPIMYPEINTLVDELH
RRHISTFLVTNAQFPDRIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLKA
LQDKEQRTVYRLTLVKGWNAEDVEAYANLLGIGKPDLVEIKGVTYCGTSATSKLTMDNVP
WHSDVKAFSEALAMKSSGEYEVACEHAHSCCVLLAKVDKFKIKGEWYTWIDYERFHELVA
SGKSFKTEDYMARTPSWAVYGAEEGGFDPDQSRYRKERRHGAASVQT
>E3QIR0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum graminicola (strain M1.001 / M2 / FGSC 10212)|TrEMBL
MASYLEPAGFKDMLNNAHDAWQQIRIPVILFAAFGLLVLRFYLHSTKEKGELKAIPKVYN
REESATKLVDQKKEAKTDGELSPPSPTAEPKAQKSNGPKRIKGGLVKRATSDSSRGEALA
RKIRPLVFFSSITANTSKIAKEYAERLEKELQKVATDTNCFFATPEVLDLAEVDFDDYFI
TPPKSEEDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSLLLGYSVFGFG
DREGWPTEDDGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVVDVLG
MLAKTGSLGEGLPGSGAPEESDDESAEEDDDEVLIEDSEAKPEKLKNRKNIDDVEDLGRI
MKSSNPDAGTKSRTVAAPIAVDFTTYGKTAQKKTPTSVVKEMVPKNSPTYASLTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPELIFDGVKANHYSKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYC
GTSTASNAGLSMSNVPFYWEVAEFVKALEKRLNEKGLGYGIAAEHAHSCCVLLASERFYV
DGKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGNGGFDPRDERVDRKGRK
IER
>A0A2T4BNB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma citrinoviride|TrEMBL
MDAAYRLQLEALVADLVDVWHAYRTPIILSSLLLLTGLRIFLHTTEDRESLVALPKVYNE
PQQSQASEKTIPKAQLVAETEKKSSGPRRIKGGVTRKSSQEGKTAPAEHDRPAKVLVFFS
SVTTKTEKIAHDYIKTLETFLDQKAKETDGKFLKPELLDLTEIDFEDYFVSPPKSAEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLVGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHVERFAEWTSGVQEVIAQASQTGFLGEG
VPGSGDAVESDDEEAEGDDGEVVFDDEEPGNAKESDDSRPLDDVEDLGKMIRPNKDGSEG
SRKAPLAVDFTTYPSANKRKGQAPVIKEMVAKDSPTYNALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEM
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEVEGYARLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALDKRLQEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQRF
FELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAVVSREAPE
>A0A6N2BT16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Solanum chilense|TrEMBL
MSLSLSSYPTRFAILTLLSATTVFFFYKSRRHLSKRLKSLKPISQNPISKTPRGKIFFIS
QTGTSKTLAKSLHSLLNLNGFEFDLVDPKEYEPEDLHKESFVVIVATTWEDGKPPPNAGF
FVDWLTESADDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVGRDFSKKLKKLGGVEVLEV
CEGDVDEGSLDEVFGKWSKRIVGILSNLGENGGDMRNGVGDGSEDEAVSEGDDDEEYDDE
FEENDEESGIVDLEDIAGKGPSRKKGVNDKLVNGKSNGGTVNGEKAMVTPVIRASLEKQG
YKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWTWKMDDPIEIVNTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEP
IMYPEINSLVDELHRRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPL
FGDFWERFLDSLRALKEKEQRTVYRLTLVKGWNTEDVDAYSSLFSIGKPDFIEIKGVTYC
GTSATSKLTMENVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKIDGQW
FTWIDYEKFHDLVASGKPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRFKKERHHRSSRQE
NGS
>A0A482T6B3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula hispanica|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>I3ZTD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus cleftensis (strain DSM 27260 / KACC 17922 / CL1)|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIASH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKIKETLGLMKDAQTRTVIRLTLVKGE
NMHNPEGYAKLIRLASPMFVEAKAYMFVGFSRNRLTINNMPRHGEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTGIGGRFIKH
>A0A1F9Z879|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon RBG_16_68_13|TrEMBL
MDPERQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPTVD
SCNLGCIFCWRTQEWGSNSLAEADDPREIVEGSLEAQRLLLSGYKGNPNVSPERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDEFKSRHMSTFLVTNGTTPGVLRRMWDEGRLPTQLYVT
VAAPNKEIYRKLVVPKSETEWEKLTETLALLPELPTRTVIRHTLVDGWNLGWEEEYAALD
AIGRPMFIECKGYSFVGESRLRLREENVPSHASIRAFSERLADLCDYKVAAEREDSRVVL
LTPDGRLRPLSP
>A0A2E4JX03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MVQSPVTKXEPRIASKLAKQRYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGC
MQMAPNVDTCNLGCTYCWREPHSDTLNKIDDDPYELYLESVRAHRRLLTGYGGNPKADRE
KWLEAQNPKHVAISLNGEPTLYSRLGEXLDICHQHGTSTFLVTNGSLPKVIEELDPLPTQ
LYVSVDAPNKETFDRLCKPKFDQSAFHKLEQTLELLPSLDTRTVCRHTLIKHESLGFHED
YARLDNLADPDFIEAKGYVFVGNSRNNLSIDNMPSHSDVMEFSETLAPLVGREVLSDRSE
SRVALIGREMIPVTLPDKVRDLPADLGIAKPMRINLPQA
>A0A1V5B8Y7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaU1.Bin112|TrEMBL
MQSENEATKTLARQGYHLVGSGAVKPCLWLSRAMRGGDQCYKHHFYGISSHRCVQMTPTL
ECNHHCLHCWRPIDDPVPTAAPLEPAELLEGILRGQNKFLSGYGGAKTTDPARLAEAQKP
RHVAVSLMGEPTLYPYIKELLDLIHRRGMTSFVVSNATNPEVIAELQPTQLYLSLNAPDE
ELYRRVCRPAAAFWQRIQESLQIIKEHRTRSVIRLTLARGLNMERPEDYARLIARAEPDF
VEVKSYMHLGRSRDRLTREAMPQHQEILQFASSLGESLAYDLQADVPLSRVALLSSGRAN
RQLMD
>A0A327HM75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDQRLKAKLQQQRYHLVGEHGGVKVCHWTKESLLRDRSCYKGKFYGVKSHNCLQMSPVVD
QCNLACTYCWREPHMDTLGLKDQDPLDMLYESVRAQRRLLSGFGGNDKVNKEKFLDAQNP
KHVAISLNGEPTLYRRLGEYIDECHKHGMTTMLVTNGTLPKVLERLDPLPTQLYVSIDAP
NKEVFDRICRPKWNNGVWEKLEKTIDLLPSLDTRIVARHTLIKGENMFGYEKEYARLDER
ANPDWIEAKGYVHVGNSQNNLDITNMPYHDEIIQFSSKLAELTGLKILDDSKPSRVALIG
KKKVPLPIPEIVKEFPKDLGIAPPIKHLPLL
>A0A534KWH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MRSAVDSEKREVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMT
PAVDACNLACQFCWRTQEWGSDSLLVADDPSFIVDESIRGQRELLSGFKGNPNVSPERFL
EAWHPTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQ
LYVTVAAPNEGIYRKLVAAKSDHEWKKLKETLALLPTLPTRTVIRHTLVEGWNLGWEDEY
AELDRIGRPMFIECKGYSFVGESRLRLEANNVPSHASIRRFAEGLADRIGYQVAAEREDS
RVVLLTTDGQLHPILH
>A0A2E9BFX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKSKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELSDQDPLEMLYESVRAQRRLLSGFGGNPKVPREKFLDAQNP
KHVAISLNGEPTLYNRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGKNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTSENMPFHDDILEFSNALAPLTNRKLLDDSPPSRVALV
GKEIVPIPVPEATMFFPEDLGVADPVKHLKVIQ
>A0A2E5QE20|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPELKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLTGYGGHDLVPREKYLEAQDP
KHVAISLNGEPTLYRNLSEYMELCHNHGMTTMLVTNGTLPKTLENLDTLPTQLYVSVDAP
NKKIFDEVCRPKWNDSAWEKFEETIDLLPSLDTRIVCRHTMMKGINMDSKSIAEFAELDK
RAEPDWIEAKGYVYVGHSRENLSVDNMPSFDDIMDFSNHLAPMVDMEILSSSRPSRVALI
GREIIPIPIPEQTMHFPADLGVAPPVKKLKMA
>A0A2D7BEC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAGKLAKQRYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYQLYLESVRAHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIEKLDPLPTQLYVSVDAP
NKEIXDRLCKPKFDQGAFHKLEQTLELLPSLDTRTVCRHTLIKNESLGFHEDYARLDNIA
DPDFIEAKGYVFVGNSRNNLSIDNMPSHADVMEFSERLAPMVGREVLSDRSESRVALIGR
EMIPVTLPDKVRDLPADLGIAKPMKLSLPQA
>A0A2D8ANK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MVQSPVTKIDLSIASRLSKQRYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGC
MQMAPNVDTCNLGCTYCWREPHSDTLNKIDDDPYELYLESVRGHRRLLTGYGGNPKADRE
KWLEAQNPKHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQ
LYVSVDAPNKEIFDRICKPKFDQGAFHKLEQTLEILPSLDTRTVCRHTLIKHESLGHHED
YARLDNLADPDFIEAKGFVFVGNSRNNLSIDNMPSHSEVMEFSEKLAPMVGREVLSDRRE
SRVALIGREMIPVTLPEKTRELPADLGIAKPQNFSLPQA
>A0A6H0XW98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Peltaster fructicola|TrEMBL
MVASELLEEAISIWHAHRHGLLVLISIIIIVLRLVVFKPRPQAHENVINDTPDPKAASRT
EVTHYHEKPPLIAPPSNLRVVDNGPRPGLRSGPKRISGKRFSPDKIANEHTVSVRPVIFY
FSVGGSTRARAEELAQSFSTSSQTVACHDLAEIDHDDFFITVPETKAGTSLLYLLLIPSY
DIDTELANFLANLAEIHHDFRIDTGPLAQLAGYSVLGFGDSQDWPTEREGFCSQAIEVDQ
WMSKLTAGRRAFPLGLVDVKKTGVSARIDEWHRGVEDIMRDLAQGKGLGEGVSGSGDPYE
SGDEIEEDDGIETAPRPSKTSKVTTDLEDIRAPPPVDFTTTASAPKAMVPVASPTYNSLT
KQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCVFCWR
HGTNPVGTTWRWQVDQPDLIFDGIKKEHYRKIKMLRGVPGVRAERFEEGMRIRHCALSLV
GEPIFYPFINELLAMLHKEHISSFLVCNAQHPDQLATLGPVTQLYVSIDASNKESLRRID
RPLHRDYWERFIRCMDILRAKRNTHRTVFRLTLVKGFNIEEEAEGYADLVERALPSFIEV
KGVTYCGTSTAAGAGLTMQNVPFYEEVTAFVLALEAALLKRGLDYGIGAEHAHSCCILLA
DKKRYFKVPKDAQDNVKRWHTLIDYPSFFSLLESGKPFGPEDYIGSPTAEWALWGNGGFD
PRDERVDRKGRAIV
>A0A7K4BMF0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MRSEACKALRKQGYQFITPNSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LKCNQHCLFCWRSFEHEVVEEEECPPEVIVANLRRVQKKALSGYKVSPYVEPEQFAEALA
PTMVAISLSGEPTCYSSLPELVDALNADGYTTFLVSNGTKPDVLARCRPYQTYVSLDAPD
RETYLALCRPVEDYWDCIQESLAGLRDRRSAVRTTVVRGYNDFSPERYAAIYQDSGARFI
EVKGYMHLGYSRNRLQRDRMPEHHDIRAFAEKITEHCDYAIKDESPVSRVVCLERKI
>A0A0J5Q3G6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus fumigatus Z5|TrEMBL
MAEHSTAEGLLVFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSRESSNKATAQKAEQQPALANGSAKPTSGPKRVTGKKPSKVAGRRGQTEDAEPL
NFIQPIIFYASLTGNTERYAKVLLDELRVAAQKRADLRDRERGLLPPQIYDLSYVDLDDY
FTSAPKPPPTSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAETSLKEWSLGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDLLHGEHISSFLVC
NAQHPDQLHALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLNILREKRHVQRT
VFRLTLVKGFNIDDEVIGYADLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEREK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A834BAA1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPVAIINLKDYDPDDN
LVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEASSDFRFGKTYLKGMKYAVFGLGN
SVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEADFRAWKTKFVFQLQ
VLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEREKEQQEEKTGLFRN
TVKKEAGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGV
PGVKEERFKEGMTVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNL
TPVTQLYVSVDASTRDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVD
ELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVALIPDYEI
ACEHEHSNCLLIAHKKFKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPW
ALFGANERGFDPKDRRYQRKNKSKDISGC
>A0A0B5GZU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. CBA1115|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>A0A842LMQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobi archaeon|TrEMBL
MREILERQGYHFIGDAAVKSCLWTKKSLRGEGECYKSKFYGIASHRCIQMTPSLLCNQKC
LFCWRAFESESVSFDPPEKIVEGCIREHRRLVSGYHGYEGTSEERFREALNPKHVAISLS
GEPTLYPHLSELIELFHERGLTTFLVSNGTNPEVIRRVRPTQLYISLDAPDEETYRKVCQ
PVGDTWESVLESLRALRHHPSRTTIRVTAVKGYNMKDEENYGKLIKDASPDYVEIKAYMH
LGFSRMRLRREAMPSHEEIRKFAMKIAEASGYRIADESEISRVVLLSKDGSVEKLKIKQS
D
>A0A842XJG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MATLKYHEETRKTLERQGYHFVGTHKHSAVKTCLWLRKSLRGEGNCYKGKFYGISAHRCI
QMTPSLFCNQRCVHCWRPLEAFNIAAEEEPVVWDAPEELVEACLKEQKRLISGFKGSGKT
SMDAFTEAEVPKHAALSLIGEPTLYPYLKELVQEFHSRGMTTFVVTNGSNPNVIREIRPY
QLYLSLNAPDEATYRKVSHAQYWQRLKESLEEMRRLKSSTRTAIRITCIEGFNMKSPEGY
AELLERANPDFIEVKAYMHIGYSRKRLNRDAMPTHSRVKDFATEIAERLAATSHYEIIDE
SEISRVVLVASTKNRLKLY
>A0A2P9BU40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium gaboni|TrEMBL
MGIVDQEFLLKNILGTHCNEKKVKINISVIYGSSDGNSYNRAKDFLNELIEYFNNVHLFL
NDINEIINKDIYINHINSKNNYSDVVQKKDYNEKKIEIKNNYKNHKCDDHDNVGSNIIFK
SNHINPSLNRNDMNILENEIIEYFKLRFDQYQVNNNNNNKKKNKEEISRSGYENMVTLYF
NKNINYLESYKENIKMFNSKFRNYVDCIIDNNKIGKIYFNLIDGNNHDYYSFFDSTENYN
LNMLFFFISTSSHGSFPNNSFKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKY
FCIPIKKCEKYIHSLGAQKLYKTLKLCDTQDNEETLFLWKCNIFKTLSLSLFFYSFNYMK
RWYMNKTIYDTLSYYCYFFSNHTNFYVNQSEDNKYIHDQEEKEKKKKKKKKKKNSHDHSI
NSMDILQVCHSNKEYKENNALIDHNNNKCFNNEIYNTHSGIYYSNVKDVQQMCLSNIDNE
ENNLVNNEKKKIKDKTNITMNEKREEVDVNEDIDLLHGDIQKIEGCTNCNCESMNEYNDK
NNTYDTNHLSNTNNVETYKDSTSESEASSNDSYVDDEDEQIEVEDLISGEKKDMLSSSQR
NKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCV
FCWRHHKNPVGVKWRWNMDKAEIIVEDIIKKHKAMIKELKGIYGIIIERFEKAMNIKHCA
LSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPAELQNLNPVTQLYLSIDAPNKEAL
KNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEINSYINLIELGYPDF
IEIKAVTYCGSSQGYQLTMKNIPWHEEVYQFAWNLINKKKSLSDIYEISCEHKHSCSILI
AKKIFKINNKWNTWIDYEKFQQLIKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVY
TKGKYKNKNQPS
>A0A7C4JNK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Staphylothermus marinus|TrEMBL
MIEPYNPRIVEKQREEFWNQNPVYRLLYDRMRKQGYHFVGTTGVVKRCYWTREAILHGRF
CYKCLWYGIESHRCIQFSPTAIWCWNRCMHCWRIQPSDIGLHWDETKLPVIDEPEFLVEE
SIRVFKHIIAGFRANPNANNSFIEEAMNPKHVAISLVGEPLLYGRLNELIKEYHKKGLTT
FLVTRGVRPDILASLDEEPTQLYISLEAWNRDKYVEFNKPIVPKAWELIMESLELLSSMS
NPTVIRITLIKGFNDNDEAINGFKKIIEKSQPWYVEVKAYMYMGYSKNRLKPDNMPSHEH
VRNFALKLSVETGYEYIGESIPSRVVLLSRVGEPKRHGKGCPDGVKHPEKYVPLLTQEYE
EASDD
>Q2H148|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)|TrEMBL
MSTLFVLSLLRIYLHSSQPKQELRVLPKTYEKVTLDEKRNADEKPKPVIKEDDSEGSEYS
RTINDKKGAKRGPKRIKGDVQKKGRGATETEGEARKIQVLIFFSSLTANTPKIAQAFTQE
LAETLGCSSEGKLDSKFLPPQVLDLAEIDFDEYFITPPKSEGEKTDCFYLFVIPSYNIDC
INDTFLEHLQETHHDFRIDTSPLAPILGYSVFGFGDREGWPTEEEGYCFQAKEVDRWMAK
LSARKRAYPLGMGDWKRDGKERLMEWRTGLTDVLKQLELTGALGEGVPGSGDPLESDDEE
EAEDDGEVVIEEVSMSKATKGRGSGSLEDVEDIGRIMELSGTDGPGKKPAAPLAIDFTTE
GKPVTKKTPATTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGINSHQCMESTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPQLIFDGVKENHYKKI
KMMRGVPGVRAERFAEAMRVRHCALSLVGEPIFYPHINEFLAMLHAERISSFLVCNAQHP
DQLAALQHVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILRERRFRQRTVFRLT
LVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSTSSNAGLTMANVPFYQEVCDFVM
ALEKHCASAGCSTASRPSMRIAAASCSRASVSAWTGSGTR
>A0A371R556|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum aerophilum|TrEMBL
MSCEYEGLGRYHVLEGPRIKIRASAARALIERHYGVAGHAAVELCKWTKDAIEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLICSNRCVYCWRPTEEFDVISLNERFYMEPEEIVRGVLE
ERRRLLSGYWGHPKGRKRVKEALEPTHWAISLSGEPAMYPKLPELIRLIKSLPSTKSVFL
VTNGQHPEMLRRLIEEDALPTQLYLSTNAPNKELYYRINVPVYNKEDAWEKWLESLDIIA
KAPTRTVLRITLIRSLNFDDKYIPEFAQIVKRGNPHFVEVKSYMHLGHSTFRLKREDMLS
HEEVKEWSFKLLKELEKIGARFAYMDDDEPSRIVVLQNLDRYVDRWIVPPGAPI
>A0A6G0RXL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora fragariae|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLSSHPHTLPRNAAAIDSPKRKAKKSPRKVQDKPSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEDIVVAVL
STWTHGKPPEDALVFCNWITDMTQDFRVSKSWLNGVKHAVFGLGNAEYDEDYGTAAKNLD
RELSELGSPSLVQLGLGDDNIDQFKQFDVWMDNLVAAMCEYSSEKAVAALKKSDSPVKAG
KKEWLSQNEFRRQKRAKKAEVAAANGETVELNEEDLVNEQFLVDEFSDDEEQNQEKADDD
SGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRG
RGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSI
ERHQGMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFL
VTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQRT
VYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGF
CSALCDRVSGEYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELVTKFYEDGTPF
TADDYTAPTPHWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>D7KSL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabidopsis lyrata subsp. lyrata|TrEMBL
MSTTSSVRARIAFVALLSATTFYCIHKYRRLKRLKNLSLNPSSTSKPSRGKIFFISQTGT
AKALAQRLHELCASNDIAFDLVDPRSYEPEDLPKENLVLFIASTWDGGKPPKNGEFLVNW
LGESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEGD
VDDGELDRAFQDWCGGVIGVLKGGSAEETNGVSQQIGAVENDLEYYDSTDDEDEDNDADG
GIVDLEDIAGKAPSKRNGVVKVTKVDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSV
IVKGALDLHTKMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGR
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
ADVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTEKFKVDGKWFTWIDYEKFHDLVASG
ESFTSTDYMAQTPSWAVYGAQEGGFDPEQLRYKKERHHHPKPQAVLA
>A0A3M2S5V9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium kuroshium|TrEMBL
MDWANYSAPSRLDSFVEDLVDVWHIHRTPILVAALVVLGTLRIYLTFIGQKTELVALPEA
YKEPPKPKAIIEAKTPAVETIDEKKDVKPQGPRRIKGGIARKPSKKNEQEKDITRPIMVL
IFFSSITTKTDKIAQAYLKELEVKQEELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKMH
GDVDYFYTFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPT
EGEGFCFQAKEVDKWMAKLTSRKRAYPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDIAEDEDDGEVLFEDDDTSDPKKKNGRPLDDVEDLGRMIRKDD
GSTVQKAPLAVDFTTYSSTKKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPD
LIFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHA
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLEIL
REKRNRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCEFVKALEKRLKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKK
FFDLLEERGPDGDWTPEDYMDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>W7EGC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bipolaris victoriae FI3|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLPILLSALVVATIARLIIYSRDRREKLPKSPVPQSPIE
KQKVELKPEWLPEYTTTLTSPDLNVDNHAEDDTSAVVAATKVKKGPKMVKGRKIPKKSVT
PTLTFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTGCDQASSFLEPQTHDISYI
EHDDYFITPPKADPNVKYFYIILIPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGDAEKRLEEWRIG
VQDALVELAEGRGLGEGVPGSGDPAESDEEDVDDAEEGNGESSRVDDVEDLGSMVNSSSS
PIPIDFTTYKKSAPKLKSAPAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPEMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLDIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVHGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELNSRGLQYGIGAEHAHSCCVLLADRTRFMRDGRWATRIDFERFFDL
NEGKVQGTRVEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKAEAEKS
EGQAEQTKKVALEF
>A0A842NZR9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|DPANN group archaeon|TrEMBL
MSLKQLSDKKYIEELEKQAYRVVGSHSAVKICGWTKNMIRGEGGCYKLKFYGIMSNQCMQ
MTTSISCANRCTFCWRGYKAPVSKEWKWEVDDPKMILEESEKAHHKLLVGFKGNKEANMK
LFKTSHTVKHVALSLTGEPIIYPKMNEIIKLFHERGISTFLVTNAQYPDQIKDLEPVTQL
YISLDAPNKELLKKIDVPLFKDYWERLNKSLQYMADKKYRTCIRLTIIKGLNDVELENYA
KLIEKGNPDFIEVKAYMFVGASRSRLKIDNMPLHEDVVAFSKELLKYLPDYDIVSEHIPS
RVVMLAKKKFKKNNKWYTWIDFKKFHELTKKGKEIKTEGSLLPTPQTGLSGKGTKDLIKK
REKQREKQQKLKISELQNSKTILKEEIEMWGSNDG
>A0A7L1E8V0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oenanthe oenanthe|TrEMBL
VSMDSWSFFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKAHGNPSSPEGTA
DKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLDLPVEVINMGDYDPE
DGLSEEASSRNICVFLVSTYTDGQPPESAAWFCQWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLTR
LQALCRGEKKPCSGKCKKGKCKSSGEQSKESSDNEHRTSEHENTEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKVLLLEGVWNVHGVSHSGYHLVYFVCQFLQAKLNCLMNCA
LFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDPPEVILQEAIEKHQNMIRQFKGVAGVKAALLEEALAVKHCALSL
VGEPIMYPHINHFIRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRI
DRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDEVKAYADLISIGKPDFIEVKG
VTYCGESSASSLTMANVPWHGEVLSFARELARLLPEYGIACEHQHSNCLLLAHCKFQVDG
HWRTWIDFGRFQELVQEHEQSGGCRSFSAAEYTARTPAWALFGAGEEGFDPLQVRFHRRS
KAQHVSGC
>A0A662IHJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVIKKTQQALYQTYRKLDILRLVYRRLGYHFAGVQAVVKPCHWLKKSLLTRGKSFCYKQL
WYGIPSHRCLQMSPVIVCNFQCLYCWRAHESDLHLTPIDPKMYEKIPYDPPKRIVDETLR
AWRSILAGFKGNPKVDPKMFEEALNPIHVTLSLTGEPTLYPWVGEVIDQYFKQGFKSVFL
VTNGSMPQVLRELKREPSQLYVTVPAPDKHTFRIITRPLIPDAWERLVETLRELENIRPP
TVIRLTLVKGLSLKNPEKYAELISLARPTYVEVKAAMSVGYFRRRLNKDNMPKHAEIKQF
AEKLSDHLRKDGYKIIGEFLPSRVVLLSTLEQPMKIIGEKG
>A0A662V120|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVKEGITVLYSRLKSQKYHIVGSHSAVKKCHWTHAALLERRFCYKCLFYGIETHRCVQMS
PAVLWCWNRCLHCWRFRPSDAGIDFDDTRLPTVDDPEFIADMVIKEHLRILSGYFGNPKT
DKELLKEAMEPKHVAISLTGEATLYPRLSELIEVFHRRSLTTFLVTRGIRPDVLASLSEE
PTQLYISIEAYSKETYNYFNQPVVPNGWELTLKTLEILPSFSSPTVLRITLVKGFNTHEK
AIHEFAKIIEIAEPTYVEPKAYMHVGASITRLRREHMPTFSEVMEFSKKLAELTGYYLVT
YSVPSRVVLLSRFKKQPFRYGKGCPWGWSKPDEGSEESGEYGKLKHLV
>A0A7J6Y2P0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi|TrEMBL
MKESVSEALWWVLLGALIPLVTLTLTTLLDRWVSRRRKRQMEVARAQASKEGERTWTEPN
VHNSTGKTNGNGSTIHDAVRGSKGGVDVKKILIAYATQSNTACKLAHKLFSTLSTALHES
RDEVQGDSSSCVCSEGPSSCCATSHTARHLPELKVLQLTEEGRQCGVEHLLENQAYGLII
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKFAIFGLGDIAYGEKHFNRFA
KNVYMWCKGLGATFVVPPVYASEANTIPLFNVFTASLVKWVGRVTFTADGVTILKRQQKQ
VKEKEQLKLCNDVELKGHATYNSEEDEEDEEREEEDEENGRKKRNHNSEGDVEDVVTDDE
DEGEDANGQSGSVDHAVQASSSEPPELLYPRLRQNLQRQGYHLIGSHSGVKLCRWTKAML
RGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRTFRWKVDPPQLLIAE
GIAGHQKMMKQMRGVPGVTSERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHERGISS
FMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRRKPQ
RTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLRMKENVPRHEEV
VRFCAALCEALASDTAPRDKRTWLGTEPETGPLQRDLNCDEKRTSVNNMENNNRRCNRND
EEEGVGINFSGPYSIACEHEHSCCVLIALRRFLVNGVWHTWIDYEKFNALARSGRTEFTA
AEYAAPTPSWAVFCSNEKGFDPTQVRVHRKSGNTTVVTSSC
>A0A674NUL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
MKDYDPDDELAVECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRAEGDCNVVKSRNGSVQADFLAW
KVKLLKRLQALARGEKKICSGNCKTEGKCKNKRKVKGEENAALQNNSSEGELIESSSDEE
ESGLQEEKQSGTMLDMEDLGNIMNLVNKTKVSVRPFDSHIPLISLSCAGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPAEKILQDALEKHQNMIRQFRGVPGVKLERYEEGLEVKHCALSLVGEPIMYPEINTFVR
LLHTHNISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDYWPRFLDS
LRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASSLTMA
NVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELV
GVYEKTGGQRSFSALDYMAKTPNWAVFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A0E3LMG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina barkeri str. Wiesmoor|TrEMBL
MEEKKENTGENFPEAQKKNRKEDTASLPFDIPDFKTLLKKQGYAMAGRHSAVKTCLWLRH
AMNDQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPEKIVEE
SIACQRKLITGFGGSPNAIKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKKRGFTT
FLVTNGTVPEMLAQVSPSQLYMSLDAPDLETYLKVCQPKSPALWEKINESLSLMKQKKSR
TVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVLEF
SQELAKYLGYEIADESEISRVVLLSKDGRKSPVNGEKISR
>A0A0B4ICE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium guizhouense (strain ARSEF 977)|TrEMBL
MSAVCEKTDPLQGVFGGLPGAKFDDIVELWHGHRTPIIICALVVLVAIRIYIHKIEEAEP
LRALPKQFEKRLEPSSANKLPSAVNSEKPIAKPNGPRRIKGGITKKPATEETKEYDKSRP
IKTMIFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFFVSP
AKTVEDAYLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFGDKE
GWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKGDHAERFDEWSSGVQEVIAHVA
STGSLGEGVAGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRMLRT
SGGNGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSIVGS
HSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHI
NEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTS
TSSNAGLSMSNVPFYWEVCEFVKALEERLKAKGLKYGIAAEHAHSCCILLASERFLVNGK
WHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIEN
VVVREAPPPDSW
>A0A397YS48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica campestris|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLNPSSRRGKIFFISQTGTSKSL
AQRLHKLLESNGIAFDLVDPASYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSCCRFGVFGVGSRAYGDEYNAVAKELSRRMVGLGGAEMVPLGEGDVDDG
ELDRAFNEWCDGVIRVLKGGSAQAREANEITQNGVVESEEEYIDTTDEEEEEDSNDIVDL
EDIAGKAPSRKNGVVKVTKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKG
ALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIST
FLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQ
RTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFT
SRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>D1J9A0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MEPKAISNYHEATLEKQGYHFVAPHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAHRCV
QMTPCIFCNQRCIHCWRPLEAFNIGEEAVAWDTPLEIVEGCMKEQRRLISGFKGSSKTSK
AAFAEAEEPKHAAISLIGEPTLYPHLQELIQEFHSHGMTTFVVTNGTNPAVLREIHPSQL
YISLNAPDEAIYKRVAHADYWAQIQESLEVMKRMKERTVIRITAMAGTNMVDPGGYAELL
ETANPDFVELKAYMHIGYSRKRLSRAVMPTHTEVKEFAGEIAEHLTASGYNYKIVDESEI
SRVVLISNLSSRVKALPKL
>A0A428S882|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium floridanum|TrEMBL
MDWANYSAPSRLDSFVEELVDVWHIHRTPILVAALVVLGTLRIYLTFIGRKTELVALTEA
YKEPPKPKAVVEAKTPAVETIDEKKDVKPQGPRRIKGGIARKPSKKNEQEKDITRPIMVL
IFFSSITTKTDKIAQAYLKELEVKQEELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKMH
GDVDYFYTFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPT
EGEGFCFQAKEVDKWMAKLTSRKRAYPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDIAEDEDDGEVLFEDDDTSDPKKKNGRPLDDVEDLGRMIRKDD
GSTVQKAPLAVDFTTYSSTKKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPD
LIFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHA
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLEIL
REKRNRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCEFVKALEKRLKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKK
FFDLLEERGPDGDWTPEDYMDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A1J3C7N0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Noccaea caerulescens|TrEMBL
MAASSSLRARLAFVVLLSATTFYCIHKYRRLKRLKNLSLNPSTPTSKASRGKIFFISQTG
TAKDLAQRLHELCAANDIAFDLVDPRSYEPEDLPKESLVIFIASTWDGGKPPQNGEFLVN
WLSESAEDFRVGSLLLSECKFAVFGVGSRAYGESYNAVAKELSSRMVGLGGLEMIPVGEG
DVDDGEVDSAFQEWCAGVIRALKGGSEQESNVVLQNGAVENDDEYIDTTDDEDDNNAEAD
IVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEI
VKGALDLHTKMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGKR
ISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQE
KQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHA
DVKAFSEALSLKSEGEYEVACEHAHSCCVLLGRTQKFKKNGKWFTWIDYEKFHDLVASGE
LFTSTDYMAETPSWAVYGAEEGGFDPDQLRYKKERHHHPKPQPQAVLA
>A0A8C1Q0L9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FDRPQKMLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAV
CFTVNMLFKKKKMVDAVSPLLDKSVKNQKHSPEAEKVIHVSGVKVFYGSQTGTGKGFAKE
LAGDVIAQGIQCEVMDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLE
EASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCN
VVKSRHGSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKKGSCKNKKKHKEEAEDSHSL
AEKNNSEEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTY
SLWYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWSWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLV
GEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGV
TYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGE
WWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNK
TKDISGC
>C3N5C8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain M.16.27)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A4Y5SKV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus indicus|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
KEDKLPSQLYVSLTAPDLETYNRVNVPMIPDGWEKIKETLRLMNDAQTRTVIRLTLVKGE
NMTNPEGYAELIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTRIGGRFIKH
>A0A2I0VQZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dendrobium catenatum|TrEMBL
MISISTRSLGARFALVALLFSSSVFCLWKSHWLRRRRRLSTLSFASPNPKPNLTAKIFFA
SQTGTSESLARRLAARLSAHGLAANLVDPRHYEPEDLPKETFVLFVVSSWEDGKPPPNAA
FLAQWLAESAADFRVGSLILSSCQFAVFGVGSRSYGSTFNAAARDFARWMKELGAAEMMP
LWDGDVDGGEVDREFDLWSEGIMKLMKGEMSLGDVAERDEVDVLEEDVEYDDEEEDVEGA
EDDVVDLEDIAGKAPSRKMKAELVNGNGVIKEMVTPIIRNNLEKQGYKIIGSHSGVKICR
WTKAQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKEWRWKMDDP
LVIVDAAIDQHTKMIKQMKGVPGVKEQQFLEGLSPRHCALSLVGEPIMYPEINRLIEELH
RRHISTFLVTNAQFPDRIKMLKPITQLYVSVDAATKESLKAVDRPLFGDFWERFVDSLKA
LHDKQQRTVYRLTLVKGWNAEEVDAYANLLGLGEPDFIEIKGVTYCGS
>A0A7J8TUT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium klotzschianum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHGLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>W9CSV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sclerotinia borealis (strain F-4128)|TrEMBL
MDTWISRPVWLYANDDIVALWHLYRIPILLTTATFLILVRITLRPRASREKLSASPVPAS
PVLPAVKEKISPPEIDEKKTNGVKAPRRIVGGVKKRKSSEENLQAGPEKIQVLVFFSSMT
GTTEVTANAFTEKLTGNLKTRAQDQEIKYLDPELLDLAYIDYDDYFISPPKGEAGTSYFY
LALIPSYNIDTVLDTFLEHLQETHNDFRIDTAPLSSLLGYSVFGFGDREGWPTEEEGFCS
QARDLDKWLAKLTGRKRAFPLGMGDAKKDAGERLEEWREGVEDVLEHIATTGSLGEGVAG
SGDAVESDVEDIEDDDDGEVLFDEQNVASKKAKTQKKDDSLNDLEDIGGVLNNTETIENT
VEEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPKTSPTYAALTKQGYSIVGSHSGVKIC
RWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDP
PEMIFDGVKAGHYKKIKMMRGVPGVRADRFAEAMRIRHCALSLVGEPIFYPHINEFTSML
HKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRCLE
ILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGAGL
TMQNVPFYEEVCAFVEALTAALKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRIDY
QKFFECLESGENFRPEDYVGEETPEWATWGQGGFDPRDERVYRKGKNKVPLPDSQRVIMG
KVEEVKDDDEVEGEKGGNSLEF
>W9Y4F3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capronia epimyces CBS 606.96|TrEMBL
MDLGDSGATSVVLADWLDQLLIFWHEYRVVVSALFLWFLMTFWVQRVTPQVPSQGLEKPN
WPDRPERVPCTDDQAVAREVDLPKADPTRKPRPTAARVVTGRKPAGARTERRGVQRGAAS
ASSSSSTTLQPIVFFSSLTGTTERLTKRVATELEAFSVSQPAVLPPQVHDISYVDLDDYF
ITGPKTPVAVPNVRYFYLLLIPSYDIDTILNTFLAHLDETHHDFRIDTSPLSTLAGYSVF
GIGDKEGWPSEEKGFCSQAIEVDKWLAKLTGRKRAYPLGLGDVKGKGELERVLHDWTVGV
CSVLAELKATGALGEGVPGSGDADESADEEEADDGEVEEVDFPDSGRNKRRKLAATTDLE
DVGGKDGSLASPLAVDFTTYASAPSPAPTALKAMVPKESPTYTALTKQGYTIIGTHSGVK
ICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQV
DDPQAIFDGAKEGHYKKIKMMRGVPGVRSERFAEAMRIRHCALSLVGEPIFYPRINEFVG
LLHSEHISSFLVCNAQHPQQLQDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQAC
LDILRQKRFVQRTVFRLTLVKGFNVEDEVEGYAELVARGLPCFIEVKGVTYCGTSVSSSA
GLTMGNVPFYHEVVAFVEALDRALAKRGLDYGLAAEHAHSCCALMASKRFLINDKWHTVI
DYDRFFHLLDQGVDFTPEDYCKATPEWALWGNGGFDPRDVRVDRKGRPKEQN
>A0A842TIH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Lokiarchaeota archaeon|TrEMBL
MEKEYPKEYKVLKKQKYHVIGKHSAIKKCRWTHNSLVKNQPCYKEKFYNLKSHRCLQMSP
SVIWCTNNCLYCWRVNPEDCSFPFSDSNKIDDPDFILDGCYREWKRILSGYKPTSHDKVS
WKKWNEAQDPFNIAISLSGEPTLYPKINGLIEASFKRNLKVFLVSNGTQPNVIESLTEPS
QLYISLSAPNRAIYEKTCLPALRNNWDKLMRSLELLSTFKCPTVIRLTMVKDLNMCLPKE
YAKIINKVEPTYIECKGYVYVGSSRKNLTLDNMPYHHEIKDFSEKLSNLTGYNILDEHKQ
SRVVLLSKLKKAIKFS
>A0A3L6L3H0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma brucei equiperdum|TrEMBL
MLNLALHENSSAYGTCGGSLVLDAASGVSCCCSRDPKAGVAPEIKLLQLKEEATQCSTEH
LLESGAYGLVVFFVSTYTGGTAPEPSHSFASMLKDAYLDFRVPRDVFAGVNFAIFGLGDI
AYGPEKFNRFAKDLYTWCKGLGGKFVIPPVYASESNTTTLFHVFSTALVKWIGRAAFTAD
GVTVMKKKSMNGAQSLNRRLNNKNNEEEEQSVGGECVKDDEAVASGSGNHNSQNGDPSEG
CGSDDGDSDSENSDNNDDKNNNNNNSDDGDAEDVEDIVGEGDDYFSSTTNGEPPELLYPR
LRENLQRQGYHLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIASYQCMEMTPSLACANK
CVFCWRHHTNPVGRSFRWKVDPPRELIEGGLAGHRRMVKQMRGVPGVTPQRLEEALNVRH
CALSLVGEPIMYPEINTFVDLLHEQNISSFMVTNAQFPEQLRDLKPVTQLYLSIDAPTPE
ELQRVDRPLFEDYWERCLACVRELRRKPQRTVFRLTLVNKYNTENVSAYADLVRLGWPDF
IEVKGVTYCGTSSTSTLTMKDNVPRHTEVVEFCEALCQQLATSNEPKEKRMWLGRDIVEE
QQGAVAAAESGAETHVEGGMTTSSLCGPYRIACEHEHSCCVLISLRRFFIDGVWHTWIDY
DKFSKLARSGRRDFTAAEYAAPTPPWAVFQSKERGFDPTQVRVMRKSGKSEVITSGC
>A0A2P7Z1L3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Elsinoe australis|TrEMBL
MELFAELLSLWHEHRLELMVVAGVVLAFARFYHHNSSEEHKEPAHEKAEAAGLLFTREGS
KDKVAALPIVRPNPASRTKFEGPKRFTGTRKSSPDKSKDGQQRQEAIEIEPIIFYFSLGG
STAKLAERLSEQFASLAKTELSLRTPQLHNLVEIDFDDYFASPEKTPASLQRFYMILIPT
YNIDSELTTFIDSLADTHNDFRIDTAPLSRLAGYSIFGVGDVEGWPTEQDGFCTQAAEVD
KWMARLTGKKRAYPTATSDIRAAEKTLAEWQTGVSEVMTGIAAGNGLGEGVEGSGEALES
DEEDFDSEPSNTTQPNKKRKRPSRTTTTDLEDIRAPTTTTSDLEIDFTTRTTPTAPKEMV
PLTSPTYTALTKQGYTIVGSHSGVKLCRWTKSALRGRGSCYKYSFYGIASHRCMESTPSL
SCSNKCVFCWRHGTNPVSTTWRWTVDPADLVFEGIKKGHYQKIKMMRGVPGVRAERFQEA
MRIRHCALSLVGEPIFYPHINELLGMLHSERISSFLVCNAQHPEQLERLAHVTQLYVSID
AATKEGLKRIDRPLHRDYWERFLRCMDILREKRDVQRTVFRLTLVKGFNIEEEVEGYADL
VERARPGFVEVKGVTYCGTSTSAAAGLTMQNVPFYEEVCAFVEALNRALERRGLGYGIAA
EHAHSCCILMGERERFYRKDGWHTLIDYERFFECLESGKEFGPQDYVGEKTPEWALYGNG
GFDPRDERVDRKGRPKEVPQKERRVVEI
>A0A7J2NSD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MKAEIPEVTKKTMAKQHYGLAGDHSAVKLCTWLKKSLHNQGFCYKQKFYGINSHLCLQCT
PIANYCSHNCIFCWRVGDYDLPDKDTEFQKPKEIVDKMIAAQQKLLTGFKGDERTDLVKW
NDAQHPKHAAISLSGEPLLYPYLSELVQEFHDRGLTTFIVTNGVHPDALQKLDPLPTQLY
VTLVAPDKETYFRTTRSRLKDGWERLVKTVTEILPELETRKVLRLTLVKDLNMHSPERYA
ELIEKSRTHFVECKAYMAVGCSTDRLPYEAMPSHDEIREFAKNICSSINWKIIDEQEASR
VVLIAKKDYEWRKHIEKNSYEQ
>A0A2T2ZWP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coniella lustricola|TrEMBL
MAFNPSVVSPWLSQWYDTSVDFWHLYRADLILAAVVVLIALRVYFHITDSVEPPHVLPKL
HEKEGDEKPVLTEKTEDAKTVKSEGPRRIRGEIPKRKTSGTQSQKRQIKIMVFYSSLTGG
TDKLVKDYVVSLAASVDSVPRGAHVSFAKPEALDLAELDLDEYFISPPKYDKEDGTATEL
LYLFLLPSYNIDSINDTFLEHLKETHHDFRIDTAPLSSIQGYSVFGFGDKEHWPTEEEGF
CFQAKELDRWMAKLTGRKRAYPLGMCDTKRDAQERLREWTTGLIDVLGQVSQHGSLGEGV
VGSGDAVESDDEDDVDEDDGEVILDDSTQTRPAKATLTGSLDDMEDLGRVLQNAKEDGPS
KPAAPLAIDFTTTSKKKTPVSTVKEMVPKGSPTFNSLTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKYSFYGINSHQCMESTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFN
GIKENHYKKIKMMRGVPGVRSERFAEAMRIRHCALSLVGEPIFYPHINEFLEMLHGEQIS
SFLVCNAQHPDQLAALKHVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLDILREKR
FRQRTVFRLTLVKGFNIDDEVTGYADLVERSLPCFVEVKGVTYCGTSTSSSAGLSMANVP
FYEEVCEFVTALDRELNRRGLEYGIAAEHAHSCCILLGSNRFKINDKWRTLIDYKRFFEL
LEEKGPDGDFSPEDYMGEETPEWATWGNGGFDPRDQRVDRKGRPLET
>A0A842NPA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MKTTTNIEEFKKHLEKQQYELTGQHSACKICSWTKKSLKDQGVCYKQKFYGIKSHLCCQI
SPALNFCQNECIYCWRDHKNFKIDNIDQPEDIIKNSILAQRKLLSGFGGNEKVNKTKLKQ
AQNPKNFAISLTGEVLAYPKINELIKTLHQQNCSTFIVTNGQFPKKIEKIEPPTQLYVSV
SAPTKQLFNKICKPLTSASWENLINSLKALKPLKQKTRTCIRLTLIKDLNMIHPEKYAEL
INLAEPHFVEAKSYMWVGSSRERLEQKNMPRHEEVKEFAQELCKHSDYKIIDEQKESRVL
LLMKKDFKGRIMKFQD
>A0A2D6KVW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MLSKARVKDMEKQGYRLVGGHSAVKVCGWTKKAIRCEDTCYKNTFYGINSHRCVQMTPSF
LCSHRCCFCWRDIGFTPSEWKGKVDSPKEIVDGCVKAHVEYLQGFGGSARADYKRFKEAL
KPLHFAISLFGEPTFYPKLPELIDEIHRREMTSFLVTNGTNLDMLKKLLKHQPTQLYVTL
PAPDEKTYEKVCKPLVKNGWSKIQESLELLSRFKCRKAIRLTLVKDINMVNAEGYAKILK
NVEADFIELKAYMWVGYSIERLSIENMPRHPEVRKFAEEVAGLAGLKIIDEKENSRVVLL
MKKDRKDRVMRF
>A0A842V7B1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MLDPEAIARLEKQQYRIVGSHSAVKVCGWTKKLIKGEGGCYKLKFYGIMSHQCLQMTPSM
SCANRCTFCWRGYKAPVAKNWKWSVDDPKEIIDGSIAHHHDLLVGLKGSPKSDKQAYEQS
CHVKHVALSLTGEPITYPRLNEMIDEFHKRGISTFLVTNATYPEQIKNLKPVTQLYISLD
APTRDLLKEIDRPLFPDYWERLNKSLEYMSQKASRTCIRLTVLKGVNDVHPKEYARLIAK
AKPDFLEIKGYMFIGASRQRLTIENMPWHRDIVAFSKELMKFLTDYDIVAEHIPSRVVMC
ARKEFKKADGWHTWIDFDAFHELSTSGRDFSALDYVRKTPQTGISGKDTLDVSKSKPLKV
LPQVSVNENEQEVDFWKGSQEDDQTL
>A0A668UX73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis aureus|TrEMBL
MCFLPPVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKKVSKEENDKADKAPKK
NDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKALGLPAEVIDMKDYDPDDQLADEC
ISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVG
HYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSIQADFLAWKVKFLNRLKTLAKG
EKKSCSGKCKTEGSCKNKRKDGRRLIVAKCPSSCFLLLPSKDINVYMAVDHNRLKVLFLP
QSKEESQRDGQMVKLSKLNGVQKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCR
WTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPA
EKILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLH
HHQISSFLVTNAQFPQEIRYKSLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSL
KALGEKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMAN
VPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQ
AYDESGGQQTFSALDYVAKTPSWALFGAQEQGFDPAETRFQRRNKSKDISGC
>A0A068RPI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lichtheimia corymbifera JMRC:FSU:9682|TrEMBL
MNNVVNSLLNGFSSMLALSGDAPASDQGGCACAGPEGGSCCKTQQQPKAAEKDNCACGPQ
QGPTEIESMKLFYATLTGTAKTFAAELQQRLEQDNNVKIKQLQLVEITDYDNDDLLTETS
VCVFLLSCYNVEGPLDWFSKWLRDLRYDWRVDRLALQKLRYAVCGLGDSAYGEEFNVAAA
QIDKWLGQLGATRIYPLGSCDKNADQKAQFEDWADQFVKELHDKSSLEFAPAHIEYDSDA
EGEEEAEDEQEQQEVQIGSEDEMVDVEDMGKMATKLKTAKENREREEHEYTVAQAKAKRT
IGVDGHTTVVKKSEPREMVSPMLHKNLTKQGYKIVGSHSGVKICRWTKAALRGRGFCYKH
SFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMI
KQLKGVPGVKADRFQEASTIRHCALSLVGEPIFYPHINEFVKLLHEHNISSFLVTNAQFP
EKITEMDLVTQLYVSIDAGTKEGLKKIDRPLFRDFWERFLDSLEALAKKGQRTVYRLTLV
KDHNTEELDNYVELVRRGKPSFIEVKGVTYCGYSGASNLTMANVPYHHEVVDFCQKLTEK
LGPGYEVAAEHAHSCSILIAQTSFKINGEWHTHIDYDKFFELVRSGKPFNSLDYVAKTPS
WAVYGAPEGGFNPNDTRFYRKNRKVAPAS
>A0A5Q0HU74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clavispora lusitaniae|TrEMBL
MDSGPLILAVCCALYSLSGGRWTFVAAAIAGYFFSTRKAPVVPEFSASAEQKPSPIYEVD
FTHYTPTEKSTFPLKTARRARKTRSPKVFRGSKPPAKNGDASLTTALKLVESPIYIFYTT
LTGSSERIAKSLHAKLSSLDGLLHQPLLRSLDDDVDDLEEYFLKTPKNSQPNIYLLVLPS
YETDSPIDYFIEHLTDTFQDFRVDKYPLRALAGFAVLGLGDSESWGGAKFCYQARLADKW
LGKLGARRLFPVGEICMKTEGDPKAQDWINGFSELLADDTPFYIDENDAADDSDAENEEI
DADDVVDVEDMGSIIKSGSLELETKEMVAQDSPTFRSLTKQGYTVVGSHSGVKICRWTKS
AMRGRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEKV
LEGALEGHYKKIKQMRGVPGIQMDRFQEAFTVRHCALSLVGEPIFYPHINEFVGMLHERH
ISSFLVCNAQHPEPLARLAKVTQLYVSIDAPTKSDLKKVDRPLNADFWERLMACLDILRT
TQSHQRTVFRLTLVKGFNMGDIESYADMVERAQPSQIEVKGATFCGSSAGNGNPLTMQNI
PFYEECREFVQKLTAELQRRGSKYEIAAEHAHSCCILIAHSKFKINDKWHTHIDYPRFFE
LLESGEDFCDMDYVKETPSWAIWGSPEAGFNPEDTRYDRKAEKLRKKKEREGTA
>A0A218NP41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Mancarchaeum acidiphilum|TrEMBL
MSEMPQIIKEKMTHQGYHFVGKHSAVKICEYTANGIEGKTLCYKYTFYGIHSWQCIQATP
AIGCDLGCKFCWRLIPEEIGVNWNELNAVDHWDDPDSIVDGMIKEQLRIVSGYKSGADTN
LKKKRWEESRYPRHVALSLTGEPTFYPKMSGLLKAFHKKGISTFLVTNGTLPEAIAKMDP
LPTQLYISVEAPDKETYVKVTRPKIPDAWDRYMKTLSMLKTLKTRTVFRMTLVKGLNMDN
IEGYASLVKFAMPNYVEVKGFSFIGGARNEARGLNLSSMPSHEEIKEYAHKLSELTGYKE
VSEHKPSRIMLLCRDEESAKSRIIDFSKITA
>A0A3S2MR59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias javanicus|TrEMBL
MAKYLLLVLFYACYTFALDIKASQTGFSLAESYLTLLWHHRVYLYAAAALAFGLWFSLKV
ALSRKSCEKDAVSGARGAEKQEKPHQVHVSGVKIFYGSQTGTAKGFANMLSEDVKTLGFP
AEVIDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKT
YLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQA
DFQAWKGKFLSRLQALGKCEKKICGGNCKTGNSCKSETDRKEEEEEETSKEIGSEAELME
SSSDGEESDVTGERKSVVDLEDLGNLMTSARKAKGKIGSQRDGEVVKVSKLNGVKKIDDD
GERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
ATPSLACANKCVFCWRHHTNPVGTEWRWKTDPAEKILQDALEKHQDMIRQFRGVPGVKPE
RYDEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRTLDPVTQL
YVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYA
ELIALGRPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLAAMLPEYEVACEHEH
SNCLLIAHEKFKLDGEWWTWIDYERFQDLVRARRDGGGQRTFSALDYMARTPGWALFGAR
EQGFDPADTRFQRRNKTKDISGC
>A0A7R8AGK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus puulaauensis|TrEMBL
MADSSAAEGLLTLWHSFRLPFLVAIASVLVILRFRRVLQARSKAATASSVPPSPRSLSPE
KSPKPDVLPEIVEKKDAGSISSGRVSPKPTAGPKRVTGKKPTKTAGKRSGSAANDEPQPV
TFIQPIIFWASLTGSTERYAQKVLEDLRAAAQSQTNLEDRERGLLPPQIHDLAEVDYDDY
FTTAPKPPPTSPGTRYVYCFLIPSYNIDTILDTFLGHLDETHNDFRIDTGSLSNLAGFAV
FGFGDKEGWPTEEEGFCSQAKDLDKWMAKLTNKKRAYPLGFGDVKSDAESSLKEWTSGFQ
DILGDIVKNGGLGEGVPGSGDPLESDEEQSDEEESGSTKPKARGRKKAQAVVDLEDIKMS
TDGQVGSSPVPVDFTTAGAGSQAIQPTEKEMVPKTSPTYTSLTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSP
DLIFDGVKEGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLELLH
SEQISSFLVCNAQHPDQLEALHRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQKCLDI
LREKRFVQRTVFRLTLVKGFNIDDEVVGYANLVEKALPCFIEVKGVTYCGTSTSAGAGLT
MQNVPFYEEIATFVVSLNDELKRRGLDYGIAAEHAHSCCCLIASTRFKVNDKWHSRIDYP
RFFELLEKEKADGTTFRPEDYMKETEEWALWGNGGFDPNDERVYRKGKKKAIQEATEE
>A0A6A6SF98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Massarina eburnea CBS 473.64|TrEMBL
MALASFLEKLPAELLIIWHTHRVPILLLAISLATLVHLTIYLRSKRTRISATPTPSSPVE
KKDVELRPEWLPENTTLNVATLNLDEHAEDDIVPTAPMVKVKKGPKTVKGKKLSKKTQPV
APVFNHQTDKIQPLLFFQSLSGTTERYASACAKVLTEWTIGCDQSSSFLPPQIHDISYIE
YDDYFISPPKTEANVKHFYFILLPSYNIDTVLSNFLENLSETHNDFRIDTAPLSGLLGYS
VFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKSDVETRLQEWRIGV
QDALVEVAEGRGLGEGVPGSGDPAESDEEDVDDVNSDSESYNPPTTRPKKATRNVDEIED
LGSMVDPNSSESPIPIDFTTYKPKSASSKSKPVPTPKEMVPTSSPTYASLTKQGYTIIGS
HSGVKICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTT
WRWVTDAPELIFDGITTAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHI
NELLHLMHKSRISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFCACLDILRNRRFEQRTVFRLTLVKGFNMAEEVKGYGDLIERALPGFVEVKGVTYCGTS
AAGTAGLTMQNVPFYEEVAAFVTALAEELASRNLSYGIGAEHAHSCCVLLADSTRFKRDG
KWATRIDFERFYELYEGKVEGTRTDEEGNVVGWRPEDYVGDETPEWALWGNGGFDPRDQR
VWRKGKGPKDKADEESVGGKEEIRMVEI
>A0A484IHA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosocosmicus franklandus|TrEMBL
MSCSGEIYSHNSSENSLIQITPSVKDKLKKAKYGVFNHSAVELCHWTKKSFSDEGTCYKH
RFYGISTHRCMEMTPAALNCENRCIYCWRPTEFYDTLEMPSNSVDDPEVIVHSLLEERRK
LIVGYYGKNNINQSKLDESLFPEHYAISLSGEPTMYPKLPQLIKYLFRLKATKSIFLVTN
GQEPEMLYRLADENALPTQIYLSTNASTKNMFYKINGPKHKDAWERWQRSLEFISQANTR
TVLRLTLIRNFNNESRFYDDFAKIIESGQPHFVEIKSYMHVGMSTNRLEQSNMLEMEEVR
NFAKGLTSRLSNYPIMDESVVSRIVVLQNQERYISRWIEDYGQG
>A0A6I9I1Y9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vicugna pacos|TrEMBL
MDPSLNTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQDKKSQEKTVPKASQD
LMTTNCLSPPKKEIIVSGVKIFYGSQTGTAKKFATILAEAVTSLELPVAITDLKEYDPDD
HLVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEEASSDFRFGKTYLKGMKYAVFGLG
NSAYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVVKSKHGSIEADFRAWKAKFISRL
QALRKGEKKSCGGNCKKGKCESNQRGSEGTEPGPHPPDRVHQRDAEEEEPVGSTSEEESG
SEDHQSLNSVIDVEDLGKIMDHVKKEKREKEQQEGETSAFRSTAKSEASERRAMISPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVELIPDYEIACEHEHSNCLLIAHKKFK
IGREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRYQ
RKNKSKDVSGC
>A0A8C9KIQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panthera tigris altaica|TrEMBL
LDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQGFAASLAEAVTSLGL
PVAVINLQEYDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIE
ADFRVWKTKFISRLQALRKGERKPCGGNCKKGQCESSAVRSLCVPEEEPFESTSEEESGT
EDHQNLNSVVDVEDLGKIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALRE
ALTKQGEDRQERSHFIPHHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMIL
KEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFLKLLHECKI
SSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNSLKALAAK
QQRTVYRLTLVKAWNVDELQAYAELVTLGNPDFIEVKGVTYCGESSASSLTMANVPWHEE
VVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQELVQEYEDSG
GLANFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A662LXX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MSSDIRKLLEDQRYALVGEHSAVKLCHWLRKSLLEDKPCYKHTFYGIESHRCLQMTPAVF
HCTQKCLYCWRYQGFTLTEMSGTVDEPSDILQQCLDAQYRLLTGYKGDERVSSKKWREAI
EPKHVACSLTGEPTLYPFLSDFFEECHKRGMTTFLVTNGTVPEALEKMDTLPTQLYVTVA
APNEDIYKKICCPLIPHAWEKLNATLELMPSLDTRTVIRHTLVKGWNLGYETEYAKLDEK
AHPWFIEPKGYMFLGYSRQRMTMEHMPSHEEIRAFAERMASVTGYAIESERRDSRVVLLG
RGKERFIT
>A0A7C1C182|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
YALVGSHSGVKLCHWMRQSLLFGRECYKQTFYGIESHRCLQMTPTINHCTQNCLFCWRYQ
GFTQQVIENPDDPEYILEEAIKAQRRLITGFKGDPRCDQKKWREANEPRHVACSLTGEPT
LYPRLDEFFEACHKRGMTTFLVTNGTNPEVLRELDPLPTQLYISVVAPNESIYKRLCRPA
ISDGWKRLQETLEILPSLDTRTVIRHTLVDGWNMKEKYIKQYARLDEKASPMFIEPKAYM
FVGYSRKRLSIDNMPSCNAVRDFSKKLATELGYFFADERSDSRVVLLSKREKVEKIGK
>A0A7J2S507|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MDNETKNILKKQHYALVGNHSAVKLCHWMRQTLFYDRVCYKQTFYGIETHRCLQMTPAIV
YCTQKCLFCWRYQGFTKTRFTEKDIVDDPEEILDKSIEAQRKLITGFKGDPRCNLKKWEE
ANNPKHVACSLSGEPTLYPRLDEFFEICHRRGMTTFLVTNGTNPEVLEKLDNLPTQLYIS
VVAPNREVYKKLCNPLIKDGWEKLQKTLELLPSLDTRTVIRHTLVDGWNIDGYEKEYAKL
DEKAEPWFIEPKGFVLVGSSRNRLTIKNMPAHNKIREFGRRLAEHLGYEIYGEREDSRVI
LLTKDKKKVKIK
>A0A6P6B761|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Durio zibethinus|TrEMBL
MSLSSLSSRLTLLALLSATTFYFLYKSRRRKQLALNPNHRKGKLFFITQTGTSKALAQRL
LNLLTSNNIHFELVDPQNYEPEDLPKESLILIIASTWEDGKPPQNSKFFVNWLAEISTDF
RAGNLLLSDCKFAVFGVGSRVYGETFNALARDLGKRLKGLGATEMVAVGEGDVDGGALDS
VFEEWSEKVVTVLKGGLVVENENVIVYESDVESLESSDDDGAGGGEEIVDLEDIAGKGPS
RKKAVNVAETNGKLDGKREMVTPVMRANLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCY
KHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAIDLHTN
MIKQMKGVPGVTQERLLEGLSPRHCALSLVGEPIMYPEINMLVDELHRRQISTFLVTNAQ
FPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQRTVYRLT
LVKGWNTEDVDAYSKLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKSFSEALA
QKSEGQYEVACEHAHSCCVLLAKTEKFKVNGQWYTWIDYEKFHDLVASGRPFDSKDYMAF
TPSWAVYGAEEGGFDPEQSRYRKERHHKSDR
>A0A812IGZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium natans|TrEMBL
MCLSTSKSSQQQWDGWSGVGICKIHDRYASMSGTSKATAAGLEESIRSALPDSSFPEAEL
QIIVEDLATFSFDALLSRTDGVTDLVALLLSTYTDGLLPPNSAHFGTLLADHVHDFRVGR
SAMRHLHFAVLGFGSTVYADAGHFCTAAVRADAALAALGAQRAARLLRVTDTKELASQAS
SWQMEFQSAISAALQGLNIPQARGIEGRAAAEAAVSPTANPEGEDEGSDSEDDSSTTVSS
GEAAPAKGSTSDVEELAEGCAGETAKKPQDRQMLTTKHRAQLTKEGYKIVGSHSAVKLCR
WTKHQLRGRGGCYKHSFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGTEWKWSMDPP
EQIVAEGIDQHRRMIRECKGIPGVKKERFEEAMTVRHCALSLVGEPIMYPKINELVGELH
QRKISTFLVTNAQFPEAIRNLNPITQLYVSVDAGTEETLKAVDRPLFSDFWQRYLDSMKA
LKAKKQRTVYRLTLVKGHNMEEAANYAKLVALGTPDFIEIKSVTFCGESKASSLTIACTP
WHEEVKAFSEALLSKEGLESQYELACEHQHSCIVLLANKRYKVDGRWHTWINYDRFHELV
QAGADFEASDYWAPTPDWALYGSDEAGFDPNETRVYHNRTKKKAQAGLLSKVRCAKGQTF
ADPLAREMNAAKANTDVTQHVVLLDRPGDKDQKLDEMLLEHLGEDELAIVFVSTKRCVEE
IARLLTRHSYGVTEIHGDKDQRERDLALRSFTNKEKRVMIATDVASRGLDIKGVKLVINY
DAANTPEDYVHRIGRTGRAGEKGISYTFLVRDDPIDIKKAKAILEVMQTADQAIPEELRL
LVGVKASKGGGKGKAGKSHKGGGKNGGKSGKGSSKGNGKSSHGRSAGPPPGPLAGVAPMH
GGLMGGYGGSRELTEFSEWPPAQLAYLWRLTSCNLQVNAMAVEVLALDTPGFSDLSSLDG
EVDEKMVTQYLQFTRQSGEKAQLRLAHVDLGSGTDCEQRMFDLRAERELRNTERAVHVGK
KLSYSLRKSDSAKQKDFAVSAQMRRDATAGIEAADQRLAEIDAEVKELEERQTAFPWFCL
FSQLQAQELNCVRHMDLTNCGLHATGVELLQSVLMDLEHRGDGDAVEELVLDSNDLGDAS
TVALASLIRLSSKIQVLRLRNIGITDGGFSQIISAVVGNKTLCLLDLRGNGLCTLENSKV
VVQGLRRFNQLVQILVE
>A0A7S4IKL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vannella sp. CB-2014|TrEMBL
WESVQFVIGFVVTLLTALLIYVKTKRSKEPVVIPKEREETNRSLSLDQNENPAQPQQATE
IVEKSEGQSFSFSETSYALPSLTILFGTQKGTAERFSHILEKQALSKGWESVSVIDLEEY
EFDSLTDEELVIFIVATYIEGTPTDSTKNFYKMIKGEANAPRAGNLCRSVNFATFGLCNS
LYTEHYNIVGKNIDKWMARMSANRVVDLGEGDENADQDKAFSAWTKKFWRTMESSEKQIR
DSMKGNVVNDVVYSDDEDNASNAEPLLDIEDIGDSLPKKKPQIKKRRKKKSQKPEIPEED
DEDSDEDYDATKPPKEMLSSTHKLTLQKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIASHRCMEMTPSMACANKCVFCWRHHKNPVTREWRWITDGAEMIIEGAIERHKKMIK
TCRGIPGVIPERFEEGFNVRHCALSLVGEPIIYPEINEFLRMLHGKGISSFMVTNAQFPD
KIEELVPVTQLYVSIDAPTEESLKKIDRPLFVDFWQRFLDSIRALSAKGQRTVFRLTLVK
DWNMDEIDRYGELLAIGKPDFIEVKGVTFAGGGKKNQLSMTNVPWHTEVIRFCEALGESV
AGMSSDGTIPHYEIASEHEHSCCVLLANADKFKIDNKWYTFIDFDKFLELESSGKPFTSA
DYMAETPEWAVYGHEARGFDPDETRFRKVRNHKPKDGAVVEEDPGIEYAIGGC
>A0A6I8R461|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xenopus tropicalis|TrEMBL
MTQTLILGILPQAAFVAAQQVDTDMSTNAWDFAYTHLMFLWLNRFYIYSCAAIGITVWFC
SHFITARKKQQNENVHNGSLPLKTKTLKSYNSPSIKEQDVYVAGVKIFYGSQTGTAKGFA
HMLDGEITLLGLPVEIINMKEYDPDDNLIEEATSKNVCVFLVATYTDGQPPESAEWFCKW
LEEASNDFRFGKTYLKGMRYAVFGLGNSVYSTHYNTVGKNIDKWLWMLSASRVMTRAEGD
CNVVKSKHGSIESDFEAWKAKFLSRLKALISGEKKPCSGKCKKGKCKSKMKSSTDAVEEE
AKHSEHEETEEETFETTSDSEPEEHGEPGSGLIDMEDLGKAMSIMKKAKREQDTNEEARN
RGKSLQSDEAKEKEEPREMITPALQEALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILEEAILNHQNM
IKQFKGVPGVKPERYEEGLVVKHCALSLVGEPIMYPEINKFLRLLHNQHISSFLVTNAQF
PEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTL
VKAWNVEELKAYADLVAVGRPDFIEVKGVTYCGESSASNLTMANVPWHDEVVRFVEELAD
LLPDYEVACEHEHSNCMLIAHEKFKINGDWWTWIDYERFQELIRAFDESKGSQKFTAMDY
VAKTPEWALFGSRERGFDPLDKRFQRKNKTKDISGC
>A0A2H9I2E6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon B24-2|TrEMBL
MIPDEAKDRFLKAGYRIVGRHSAVEVCHWTKESLRSGRVCYKEKWYGIKSHRCLEMTPAL
IWCTHMCLFCWRPLKYTVCGEPEADDPEEIIDGCIEARRLLLTGFKGNVKVDRRKWEESI
RPTSAAISLAGEPTLYPRISELLEAFKKRGFTTFLVTNGTRPDRLRGLSTEPTNLYISLC
APDEETYKRVNRPLIPDGWMKLNESLELMKSFKCRTVLRLTLVKGLNLKDPEKYAELILK
AEPDFVEPKAFMHIGEAQSRLPRSAMPTHSEILEFSKTLSRLTGYRIKDEAPQSRVVLLS
KT
>A0A1S2ZS54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erinaceus europaeus|TrEMBL
MDSVATLDIFSLLTSLWINRFYIYLALAVGISLWICFHIVIRKQDKNSQEKCVSKETQNL
MANGYISDQKKVFVSGVKIFYGSQTGTAKGFAMNLAEEIISLDLPVIIINLKEYDPDDHL
VEEVTSKNVCVFLVATYTDGXPTESAEWFSKWLEEASSDFRFGKTYLKGMRYAVFGLGNS
AYVNHFNKVGKNFDKWLWMLGAHRVVTHGEGDCNVVQSKHGSIEADFTAWKTKFLSQLQA
LQKGEKKACGGNCRKGKCRSKWQSSEEMEPESPLQDRLHHRDTEEEELFESTSEEESGPE
DHESLNSIVDVEDLGKIMNHMKKDKKEKEQQEEKTSLWRDSVKNEDSEPRAMITPALRDA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDHPEMILKEAIENHQNMIKQFKGVPGVKEERFKEGMTVKHCALS
LVGEPIMYPEINQFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALVAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVRELVDLISGYEIACEHEHSNCLLIAHKKFKID
GEWWTWIDYDRFQDLIQEYEHSGGSKTFSTKDYMAKTPHWALFGASERGFDPKDIRHQRK
IKSKSLSGC
>W2Z640|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora parasitica P10297|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A2H9L9K7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon CG08_land_8_20_14_0_20_51_8|TrEMBL
MAISAAQIAELERSGYRFVGEHKHSAVKICHWTRKSLLGMGFCYKQQFYGIQSHRCIQLT
PSLPFCDHRCIFCWRNIDVTIPNWVDDIDDPAEILDGAVTFRRQLLSGFKGNPDVDKRKW
KEAREPKHCAISLAGEPTMYPKISDLIEECHRRGMTTFLVTNGLHPNVLEEITEPTQLYI
SVVAPDEKTYKAVCQPQVDDGWERLNESLEIMPSFDCRKVIRLTLVKGLNIRDAKGYARL
IERAMPDFIEPKAYMCVGYSRARLGIDNMPLFDEIKDFAQELSKETGYSLVDESEPSRVV
LLKRK
>A0A0K2TD14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lepeophtheirus salmonis|TrEMBL
MIKEWTLIGPLTIPLLIVIAVISTLILRRRKSSIPIDISPVKKAKEETQTSCCGSNDCCG
NDSSDSSIKKIKVIYGSEGVSKELALSIKNVASDLSVEILSSKDYYPGDEILTDVKETGL
LVVVIISTYTEGLPPPDAKYFYSWFEEEAKDFRVQHSILKGLKYCVYGLGHSGYGQEYYN
VTSRNLDKFFRQLSAETYLPLSLSDENDGTVQEEFNTWSKALMKKIKGKQNGLISEAGKE
TIQDSDTDEEYSDEEEEENEEDDGLVDMEDMGVVMKKAKEFKNSAPKDMVTPTLRKSLTK
QGYKIIGTHSGVKICRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HSNPVGTEWKWSMDPPDMILDGALENHYKMIKQMKGVPGVLPEKLAEGMDVQHCALSLVG
EPIMYPEINQFVRLLHSKSISSFLVTNAQFPDAIASMDPCTQLYVSIDASTKESLKKIDR
PLFKDFWERFIQSLKELSHKGQRTVYRLTLVKGFNVEELHDYAKLVALGRPDFIEIKGVT
YCGTSKASTLTMENVPWHEEVVNFSQTFADMLEDYEISCEHEHSNCILVSHKKFHIDGEW
KTWIDYKRFHELVSKFDVNDPSTRFTASDYMVKTPDWAVYGAVERGFNPSQTRVHRKGKK
GVKSEAS
>A0A0U3FJL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus acidocaldarius|TrEMBL
MEGQLKIDTFSVIMKELEKEKYHVVGSHSVYKKCHWTHEALTTGRYCYKGKFYGIESHRC
VQMSPSAAWCWFRCIHCWRLEPEDIGIEWDETKIPIEDEPEIIVERSIEEHKRAVSGYFG
RNGVPKNKVIDAATPRHVAISLTGEPTLYNRIGELIKEYHRKGLTTFLVTSGVRPDILAS
LEEEPTQLFVSIQAPNYKKHKIMNRPIVPNSWELFLETLKILPSFSSPTVIRMTMIKGYN
MSEEDAKDFAKLIELSQPTYIEVKSYMHVGPSTYRLTKDAMPKHNEIREFSKILANYTGY
KIISEHVPSRILLLSRLDKPIQIGNAWTDKWNWSTKDTEDDMNGEYKEAEESCTEGGI
>U9U9M0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194)|TrEMBL
MDIVEYETEDFLSESAICIFLISTYNVEGPLDWFYKWLEDTRYDFRVDKQALSKMKFAIF
GLGDSAYGDQFCIQPRNIDKWLGQLGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDP
SYALNNVSSNLNYDSYSESDSDSDNNNNSDTEMVDVEDIGALAPKLQAARKSKEEEEFVY
KNSNGRPKRTLSEQEVPINEPKEMVTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGR
GSCYKFCFYGIQSHRCLETTPSLACSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLS
NHYKMINEMKGIPGIRADRFQEAFNVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMV
CNAQHPSRLRALDKVTQLYVSVDASTKESLKKIDRPLFKDFWERFLECLDILSQKGQRTV
YRLTLVKDYNTEEIANYVELVRRGKPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFV
KHLNENLGDTYEIATEHSHSCSILIANTKFKINNKWYTWIDYDKFFELLEKGEHFTSLDY
IAPTPSWALFGSPEAGFNPEDQRFYRKSKKNNNSVKNGGC
>A0A397D9J2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAEPVAVRILYGTHTGTAKGTALSHVVDDNLEHEHVLISILSTWTGGV
PPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLGNSEYDEHYGKASKALSKHLSSLG
ASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGALRSPAASSSSSPSVKPKQQPAGW
KSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIVLELDQGDDSDDEDNRPKKQDSGV
VDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGG
CYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDDAKELVEGAISRH
QTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMYPHINEFCRELHAREISSFLVTN
AQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLTQLKAKGQRTVYR
MTLVKEHNMKELDNYVELIHLGEPDLIEIKAVTYCGKSDASDLTMQNVPYHQEVRDFCEL
LCAKLGGGYELATEHAHSNCVLVAKTKFKIDGHWHTWIDYDKFHTLIQAYYKDGTPFTTM
DYIAPTPAWAVYNAPEAGFDPIETRFRRTKEGKVVEIEYTATDSGCG
>A0A662GAA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MENIREAYRKQRYHFVGKFAVVKPCIWVKKALNSNGRIYCYKEKFYGIPTHRCLQMSPTI
FCNEECIFCWRAHLRELGSKIEITGKFESDNPELIVENSLREWRAILSGYKTNPNVSKEI
LEEAMRPIHAAISLVGEPTLYPYLGELIESFYKHGFKTVFVVTNGTRPDILEKLDPLPSQ
LYVSVVGPNKNIFNRTAMPLILDAWDRLMKTLSLLNTLSIPTVMRITLVKGLNMTDIDGY
AKLIKMAQPTYVEPKAAMDIGWFRKRLPRSAMPSSEDIRKFAKKLAEKTGYKIIDESYPS
RIVLLSKLDKPIKLIKWSEASKVAPPPT
>B8N8P5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAIILRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSTAPNQSTVKEMVPKTSPTYAALTKQGYTIIGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A4X1STU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKSLS
VSADVPLMGSQIFLRTSPWTPRCGCPSNPEQGSLRMRKRGAEEPLEGERSRRGAGPPTSP
LGKSSPPNPSRRNKLSRMFTRDLIVFGPQVGGGVGAGSLCAKCLGGGGRERRPPGPDDRG
GVPRGCTSHWDRDLAICLEL
>A0A161KAR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus chitonophagus|TrEMBL
MDIKPGKITIQANPNMPPEIANLFRKQHYELVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMETFIGTELPQPWDDPAFIVEESIKAQRKLLVG
YKGNPKVDKKKFEEAWYPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPER
LEEMIKEDKLPTQLYISITAPDIETYNRVNIPMIPDGWERIKEFLELMNGIQTRTVVRLT
LVKGENMHNPEGYARLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHDDIRKFAEALVK
HLPGYHIEDEYEPSRVVLIMRDDIDPSRTGLEGRFIKH
>A0A818YNL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood1|TrEMBL
MTVDLYIFAAGTALTGLVFYYLAGAEWSLWHLFTIPLYTFIFIVFLSLSILKRFKTQLST
KIISQDKNGITIVFGSVKGNSRTFAQLTYDKLLNELNRQVILQDLNDITDPEEFLQIQVK
NQRILLIFISTYEDGIPPPSAKWFLRYLQEAATDFRVSKNELEKLTYTIFGCGNSLYNDN
FNKVAKELDRCLLELSAKQFIPSEYADENTVKSIYGGLEGHYSKWLSQLISNLQSSKADK
CDCSNDKSINCCQSLTNNNHSNENVEQLRIESDDDDEDGGGCKNGNDDIMDLEDMGDYME
THSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENHYKMINTF
KGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHSKKISSFLVTNAQFPNEM
KTLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLDSLRALKDKGQRTVYRLTLVKGY
NTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASHLTMANVPWHEEVVTFVKLLCDRLPQ
YDVACEHEHSNCLLLANKKFCIDGKWYTWIDYERFHELVTRHKVTSGAETFTSVDYMAIT
PDWAVVGSNERGFDPNDTRWYRKATAKKNLSGC
>A0A7C4C7I1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSALPSKVEEAYYAQGYRLLGKYKHSAVKICHWTKESLRNNRVCYKELWYPPVQSHRCME
MTPYIGCNCHCLYCWRMHSGDRPGLLWREYPLDLREVDEPDVIIEDAIQRRKELLFGFKG
DQNIDRLKFEEALRPTMMTMSLTGEPTLYPKISELISEARKRGMITFLVTNGTMPEVLEE
MDPLPFQLYVSISAPNEEIYLKLMRPLFKDGWSKLIKTLELFPSLDTRKVFRLTMIKGWN
MIKHEEYVKMIYKAEPDFVEVKAYEWVGESRKRLSRDAMPYMEDIRDFAMKLSDLTGYKI
RGEFKPSGVVLLASK
>A0A7C4H2C3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MTPEIRSLYYKQGYRLAGKHLHSAVKICQWTKESLRSGRVCYKELWYPPVQSHRCMQMTP
YIGCNCHCLYCWRIHSGDREGLIWREFPLNLDEFDEPAEIIDELIEKRKELLSGWRGNPR
VDKRKLEEALRPTMMTMSLTGEPTLYPRISELIAEAGKRDMITFLVTNGTLPEVLERMNP
LPFQLYVSVPAPDKNTYIGVVRPLIKDAWERLNKTLELLPSLGTRRVLRFTMIKGWNTLN
IEGYAKIVEKSKPDFIEVKAYEWVGQSRERLPRGAMPYMEDVEEFSIKLANLTGYSIKGK
NEPSGAVLLSA
>A0A7J4RG19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPKEKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSSHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNRDVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLIQN
>A0A1F2P6U7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Syntrophoarchaeum butanivorans|TrEMBL
MDDWIRRLELQGYHLFGEHQHSATKPCLWLKKAMRGGEFCYKGRFYGVASHRCIQMTPTI
LCNQACIHCWRPFIELSEDDIVWDTPSELIQALLLEHRRILSGYGGSDTTDTKRLREAAE
PKHVAISLIGEPTIYPYLPAFIDELNALGYTTFLVTNGTNPEMLRRVRPTQAYLSLNAPN
RDLYERICHPDDDYWERIMESLETLSKLRTRKVIRLTMIKGVNMVDPDVYARLIHRAEPD
FIEVKSYMHLGYSRMRLDRSNMPSHNEIREFTGKIVDSLDGYAIEDESEISRVVLVMRED
FSDKRFLEV
>A0A3B3RVR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paramormyrops kingsleyae|TrEMBL
MMFFSVWCFLCIIAGAFGAEVEDVSEDQWDYSGYLMSVWKNRLYMYSAAAVFLGVWFTLK
MAKKKTASGQHADAGISKTAKEGGYSAVKEKRKVHVSGVKIFYGSQTGTAKGFAVDLAKE
VQALGLTAEVIDMKEYDPEDSLSEECTSKSICVFLLATYTDGKPTENAEWFCKWVEEASM
DFRYGKTYLKGMRFAVFGLGNSVYEGHYNTVGKHVDRWLWMLSATRVLSRGEGDGNVVRS
RHGSLQADFLSWRSRFLKRLQALARGEKKACGGKCKKGTCKKHKGAQEQSEPGSEGAEHQ
SSEESSSDTGSATDEETASRLVVDVEDLGVVMSRVKKAKDETDNGRELLTRRKSEEEARE
MITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSL
ACANKCVFCWRHHTNPVGTEWRWKMDPPEMILQEAIENHQNLIKQFRGVPGVLPERFEEG
LAVQHCALSLVGEPIMYPEVNAFIRLLHQRRISSFLVTNAQFPEEIRNLVPVTQLYVSVD
ASTKDSLKRIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYAELVSL
GQPDFVEVKGVTYCGESSASSLTMANVPWHEEVLYFVRQLADQLPDYDIASEHEHSNCIL
IAHRKFKVAGEWHTWIDYDRFQELVRLHDDTDSQTSFSAEDYMARTPDWAVFGACGRGFD
PADTRFQRKNKTRDVSGC
>A0A0F8HLH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei|TrEMBL
MPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>A0A8H5TZG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium denticulatum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVVLVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPLKNKEEEKDVTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVIFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEV
>A0A814Y0U2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria magnacalcarata|TrEMBL
MAVDIDILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSSKS
QPSTKNNSDEKNGITIVFGSLKGNSRTFAKLTSEKLSNELNRHVILQDLKDITDPEEFLQ
IQAKEQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAIFGCGNSL
YTENFNKVATEIDRCLSELGATTLLATELADENTGKSIYGGLEGHYSKWSSKLVSALESK
ATGKCGCRANEDSVTCCKSPSTNSHSKETNGTNEVLIESDDDDEGGNKDGEEDVMDLEDM
GDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIDNHYKM
INTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQF
PDEIRVLQPVTQLYIAYETQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKAKGQ
RTVYRLTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVV
TFVRLLCERLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGA
ETFTSLDYMAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>A0A8A3S6D0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofollis aquaemaris|TrEMBL
MRSPRCKDDSPRAALQKQGYQFFSPASTAAVKPCMWNKRSLKGGEMCYKHQFYGITSHRC
VQMTPTLRCNQRCLFCWRSFEYEVEEAEECPPEEIFANLRRLQKRALSGYKVSPYVTEER
FKEALEPDMVAISLSGEPTCYSRLPELIDMLNDDGYTTFLVSNGTHPEMIERCRPYQTYV
SVDAPDRETYLELCNPIEDFWEKIQESLGLLASRRSAVRTTIVKGMNDFDPAGYAAMYDA
ARPKYIEIKGYMYLGYSRNRLSRENMPEHAEVHRFAEAVAGHSEYEITDESPISRVVLME
RVE
>A0A8B9K0W2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
MVWQSRLYVYTAAAVLLGLWLTVNMTLKKKKTVLTSSPPLSKSEKKKEKLPEKEKVIHVE
GVRIFYGSQTGTAKGFARELADDARATGFHSEVFDMKDYDPDDRLSDECTSKMICVFLVA
TYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSEYVGHYNTVGKNVDK
WLWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRLQALARGEKKACSGKCKK
SSCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESAGEEEKAHGSVIDMEDLGNVMNHMK
KAKQSEEESQRGKLSKLNGVMKTEGEEEAREMITPALREALTKQGTALLIDLISKMLLCV
FNQSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPA
EKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINAFLRLLH
QRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRA
LGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVP
WHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGEWWTWIDYERFQELIQRY
EDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNKTKDISGC
>A0A8B9K0S7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
YLSLSLSLSLSLSLFLTLTHTLSKVEFPKIKNAIYGATLVWISCHAVRKSYFLFLSLQCT
SKMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSEYVGH
YNTVGKNVDKWLWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRLQALARGE
KKACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESVFSLLTHHIYLFYLT
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGE
PIMYPEINAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRP
LFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGVTY
CGESSASSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGEWW
TWIDYERFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNKTK
DISGC
>A0A424YVS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocalculus sp. MSAO_Arc2|TrEMBL
MHSKACDALHRQGYLFFSPLSTAAVKPCMWSRRALRGGDMCYKHQFYGIESHRCIQMTPT
LRCNQRCLFCWRSMEHEPADEHELSPEVIVSGIQKLHKKGLAGYKPHPDVTSDRWHEATG
SPNQVAISLSGEPTCYSHLPALVNLFRENGYTVFVVSNGTRPDVVAELFPTQLYVSLDAP
DEETYTMLCRPKGDYWERILESLSILSSRRSAIRITLVKGINDYSPEAYGRIIADAAPTY
VEVKGYMYLGYSRSRLSIEQMPDHAHVRSFAGKIARSAGYRIRDESPVSRVVCLEEDQ
>A0A2Z2MBQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus barossii|TrEMBL
MAITFVSNPNMPEEIARLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDVETYNRVNVPMIPDGWERIKTFLEMMNGLPTRTVVRLTLVKGE
NMHNPEGYAKLIRLASPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPHGSGRDGRFIKH
>A0A662R920|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MLISSNFESLLKKHGYHMAGSHSAVKTCLWLNKSLRGEGKCYKFQFYGIASHRCVQMTPT
MQCNQKCLHCWRPTEIDVPETGWDSPESIVEESLKAQQRLISGYGGADIIDKTLWEEAKN
PRHVAISLAGEPTIYPYLDRLIDAFHSKNMTTFVVTNGTYPAMVKQINPTQLYLSLNAPD
EDTYRQTCNPQEEGLWERICKSLDILREKQTRTVLRITLTEGLNITNPEGYADLIDRAGP
DYIEIKAYMHLGFSQKRLERSAMPTHQRIREFSEKIMQYTDYKQADESQISRIVLLSKNG
DVKKIV
>A0A849PTG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MKPELENLLKKHGYHIAGRHSAVKTCHWLNRAIRGAGSCYKSQFYGVRSHRCIQMTPTLS
CNHRCLHCWRPVEMPVPLPAPADWDSPVEIKGSILREHARLISGYGGSETTDMDALREAQ
KPDQVAISLAGEPTLYPHLPELIDLFHKDAMTTFVVSNGTQPDMIARIAPTQLYLSLNAP
DEDTYLKVCNPCGNFWEEIRESLRVLGRSKARTRTAVRITLIKGVNMFDPEGYARLLHTC
EPDYIEVKAYMHVGFSQKRLDRSAMPDHEEVRLFASEIGDRVGYRIADDSRISRVVLLSL
DGGVERIQGQG
>A0A520JWM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MRTRSRLKPGSRSDRGGYPVAGRHSAVKPCLWLNRSIRGEGSCYKSQFYGIQSHRCVQMT
PTLSCNHRCLHCWRQIEHAVPLPAPTDWDSPVEIKGSVIAKHLRLISGYGGSDTTDPDAL
AEAKQPNQVAISLAGEPTLYPHLPELIEEFKQDGMTTFVVTNGTQPDMVARIAPTQLYVS
LNAPDEDTYLRVCNPIGNFWQQIQESLEILKGARSRMRTAVRITLIKGVNVFDPEGYGRL
LQMCEPDHIEIKAYMHLGFSRKRLSRDAMPGHDEVLTFASEIADEIGYQIADDAPVSRVV
LLSRDGQARRVR
>A0A812LAT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium sp. KB8|TrEMBL
MPWPSSSSLPTAASLAALGLAGLGLAAWARRRAASGDRSSGGPIVRVRILYASMSGTSQA
TAVALEESIRRALPERSLPPEAKLQISIEDLSTFAFDTLLARTDGVSTDFVALLLSTYTD
GLLPPSSAHFGTLLADHVHDFRVGRSAMSHLHFAVMGFGSSVYADAGHFCTAAVRADAAL
AALGGLRVARLLRVTDTKELANQASEWQLELQSSISAALRGLEIPKARGIEGNAAAEAAV
AQTADQEGEEDSSDSEDDSSTTVSSGEAPAKGSTSDVEELAEGCAGDTVKKPEERQMLTT
KHRAQLTKEGYKIVGSHSAVKLCRWTKHQLRGRGGCYKHSFYGITSYQCMEATPSLACAN
KCVFCWRHHKNPVGTEWKWSMDPPDQIVAEGIDQHRRMIRECKGIPGVKKERFEEAMTVR
HCALSLVGEPIMYPRINELVGELHQRKISTFLVTNAQFPEAIRNLDPITQLYVSVDAGTP
ETLKAVDRPLFSDFWQRYLDSLKALKAKKQRTVYRLTLVKGHNMEEAANYAKLVALGTPD
FIEIKSVTFCGESKASSLTIECTPWHEEVKAFSEAMLSKEGLESQYELACEHQHSCIVLL
ANKRYKVDGRWHTWIDYDRFHELVKAGVEFDATDYWAPTPEWALYGSEEAGFDPNETRVY
HNRTKKRAQAGLLSKEQLKMYPDNPAKQ
>U4LAZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyronema omphalodes (strain CBS 100304)|TrEMBL
MSLALCKSVTEILGLWHEYRTLIFTAIALAAVLYKCLGSLRTLLHREIQSIGAATSAQKL
NGIVVDSKPTLKLADKVLEYTEVVESKLDAPRVKAKVEPKRVSGKKKGSPIGVGKSARRI
TKPQNEKDLESDIQICIFYASLTGSTSSYVEKFKNDLFSDKEGIYPKLSIPTPSNSLSGI
VPSRNILPPQLFNLEEIELDDYFISLPAPSEGKNVKYIYIVVVPSYETDSPVAAFLDHLQ
ETYHDFRIDSAPLSPLAGFSVFGFGDSSEWPESEGKFCQDAVQVDKWLGKLSGGRAGSRR
LSPLGMGDMNPASSADRQGTATANFREWRIHLEDSMQEYFETGEMSAGADLRGAVESGDE
DSDVDVAENETEKDMIDLEDLGTMINRNPTIKKSSVPAKVYLPVDFTTPAGKIALEAGEG
QSPLRKDMVPKDSVTYKALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIRSH
LCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEEIFKGVVEGHYRKIKMMKGVPG
VRADRFSEAFRIRHCALSLVGEPIFYPYINEFLALLHGSQISSFLVCNAQHPAQLRALGP
VTQLYVSIDASNKESLKKIDKPLHRDFWERFQECLDILREKRNKQRTVFRLTLVKGFNLE
DEVKGYADLVQRALPGFVEIKGVTYCGTSSAGEAGLTMGNVPFWEEVQTFVEALNTELNA
RGLDYGMAAEHQHSCCALLASRRFHINGKWHTLINYERFFELLKEGREFGPEEYVGEPTP
EWANWGNGGFNPEDERVYRKGKGPKKEIETESGGCG
>A0A2C5Z193|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps camponoti-rufipedis|TrEMBL
MPPSRTRKRPAPLAVDPAQDETARTKRPALAAVSDDPTVLAGSGTQEPDPIDLTQEPDEP
ATELYGHLGAYDRNAIRVDNVLHQQIGHLPRTVVEKIAPFMVRAIHEFDSGDIKLEAELT
GEKGMFDCPVRLSFFGPSDPAERARIEQGLKASRLLKATQLKQTKQQAQALRAASGLKSG
STSYGIGSDVGGITQAELSLEELIKKSDATEFRRGGDAIKTLAIDEAYLAAMPMAEQPPQ
LASTLLPYQLQARSHIYIILRTFADHTAGPVQLWVKSSKGMFWNLASGFVSPNAPKLCSG
GILADDMGLGKTLQVISLILTGGSGPTLIVAPVSVMSNWKQQIARHVKPEQAPSVLVYHG
NKKMTAQELTKYDVVITSYGRLAKERDQTQRTLLDKSVQWRRVVLDEGHTIRNARTKAAL
AACELQAESRWVLTGTPIVNSVKDLHSLVQFLHLTGGIEQVEIFNNSITRKLTAGERGGE
AILQALVQDICLRRKKDMEFVDLKLPEKKEFLHRIPFQPAEKVKYNALLSEARGALEEYQ
ARSASGQKGRFQNVLERLLRLRQTCNHWTLCRERIDDLMKLLEEENVVVLNDKNRALLQE
ALRLYVESQDDCAICYEAPSPPVITNCKHVFCRPCITKAIQIQHKCPMCRNALTEECLLE
PAPEGTFDDNFDTDTQSSKTDALLQIVQATVQKPGSKVIVFSQWTSFLNIVQNQLVKAGL
KFSRIDGSMNAEKRDRAIEALDHDADTRVMLASLAVCSVGLNLVAADTVILSDSWWAPAI
EDQAIDRVHRLGQTRETTIWRLVMENSVEERVLTIQAEKRELVGKAFCEKSKKENGSSFL
HIVGREDIFSSMIEDVNTLRAAEAVLKSRAAATLVEDGTRDGNATATPAISLRTAATRFG
VSKSAVARAIEQIEGRRPRVKAGKPTLLTEKEDETLVGFIHWLETTGSPATRPQIMGACH
ALMKRRNAEAKSPSDSWYGRWMATHGDLRLRIVKVYDKARRREGSGGKEVESDILSFLDE
CERSGRGPGEFAAGEVAGEHSSESSAADTPEEMELGVEPGSSCRPAVMEVPVWLPLSGTI
DGARLALADVIDLWHAYRTSLILCAVAILFALRLFLRSHQEETLVALPSIYRDRQDAPIE
KTNSGPRRIKGGAVKKVKRPVDDAASTMPPVKLVVFYSSVTDTTAKLAGIYHESLVSAVE
RLARETGRPFLKPELHHLAEMDLDDFFVAPPTAPTEAGLFYLFLFPSYNIDSINDTVLQH
LRETHHDFRIDTAPLASLLGYSVFGYGDREGWPDEERGFCFQAIELDKCMSKLTGRKRAY
PVGMGDVKGDHRERFSEWAAGVEDVVASVARTGHLGLGVRGSGDAVESDDEEVDGGGEEA
AGQQGERPLDDVEDLGKMLRTSGSKSGANSGAKPPLAVDFTTYSQQQTPAVVKEMVPRDS
PTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSN
KCVFCWRHGTNPVGTTWRWVVDAPDVIFRGVKEGHYSKIRMMRGVPGVRAERYAEALRIR
HCALSLVGEPIFYPYINEFLALLHAEGISSFLVCNAQHPDQLAALKAVTQLYVSIDASNR
ESLRKIDRPLHRDFWERFLRCLDILREKRFRHRTVFRLTLVKGFNVADEVEGYARLVERG
LPCFIEVKGVTYCGTSTSANAGISMSNVPFYWEVCDFVRALDARLADMGLAYGIAAEHAH
SCCVLLASERFRVDGLWRTHIDYRQFFQLLQERGADGDWSPEDYMGDPTPEWALWGNGGF
DPRDTRVDRKGRSMDVTVVRHRPPELEHVS
>A0A7C4R9D5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MVIRYRIESSVIRDPYTDVNSSLRKQKYHLIGGHSAVKKCLWTHKVLMDNMYCYKGKFYG
IDSHRCIQASVSTQWCWNACLHCWRIRPTDILENWDETRLPEIDDPEFIVEMSIVEHRRT
VSGYKAHGVPSEKIAEAMDPRHVAISLTGENTLYPRLGELIREYHKRNITTFLVTRAIRP
DILANLDEEPSQLYISLEAYDKETYEYFNTPLVPRAWEKTLETIEILPSFTSPTVYRITA
VRNWNMNEKAAEGFAKLIDLGQPTFVEVKAYMHVGTSTYRLSRDNMPTHDEVRRFAELLS
RITEYRIVSESKPSRVVLLSKLDKPLVRHGNAPVNWWDPDLTDFDEYISESVYGEIISK
>A0A672UWQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigops habroptila|TrEMBL
MDTWSFFSTCLVSLWLHRLYVYSAVAFGISIWIIIQFSTSKHQKKVVDHLSPLSEKIPKI
CVYVAGVKIFYGSQTGTAKRFARALAEAVISLNVPVEVISIGDYDPDDCLLEETTSRNIC
VFLVATYTDGQPTESAAWFCRWLEEAANDFRFEKTYLKGLRYAVFGLGNSVYVDHYNTVG
RNIDRWLWMLSASRIMTCAEGDCNVAQSKHGTIEADFEAWKAKFLSRLQALCRGEKKPCS
GKCKKGRCKSPGKQSKESSDHEHGASEYENTEVKPKFMRPYFSFSAPWSYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKM
DQPEMILQQAIENHQNMIKQFKGVAGVQAARFEEAMTAKHCALSLVGEPIMYPEINRFVR
LLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDS
LKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGKSSASNLTMA
NVPWHEEVVHFVQELANLIPHYEIACEHEHSNCLLIAHKKFKINGEWCTWINYDRFQELV
RAQEQSGGSQTFTGADYAARTPHWALFGSRERGFDPLDVKYQRKNKARDISGC
>A0A7C6BW58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp|TrEMBL
MSLSNQAIESLQKKGYRFVGSNQHSAAKVCHWTKKSLLDEGVCYKEKFYGIKSHRCLQMS
PSIPYCHHKCLFCWRDISITSTTWDEEFDDPGEIIEGCIEAQRKLLVGYFGNPHANQKKL
NEAQTPNNAAISLAGEPLLYPAIDELLEEYKKRHFTTFLVSNGLSPEKLKNMSMEPTQLY
LSLDAPNKEVYHDICNPQVKNGWENLNQSLELLSSFKCRTVLRITCVDGYNMKNPEGYAK
IIQESNPDFVEIKAYMFVGSSRERLKLNNMPKNDDVHHFAQSISVLSGKKIVDQSPESRV
FLLA
>A0A6V8CWR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPAIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSETINKVTSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDVCHQHGVSTFLVTNGSLPKVIERLDTLPTQLYVSVDAP
NRDIFNRLCKPKFDDHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDVMSFSNTLAPLVGREVLSDRRESRVSLIGK
EMIPVTLPEKTRDLPANLGIAKPQNFKLPSF
>A0A7K4VFU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emberiza fucata|TrEMBL
LDVSMDMWSYFHTCLVSIWQMDRFCIYSAVALGITLWIVILFTTTRAKRKVTEPGTSDKL
GNGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEVINMEDYDPEDGL
VEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNS
AYVDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTRLQA
LCRGEKKPCRGKCKKGKCKTSGKQSKESSDHEHGTSEQDNTEAEELFETSSEEEAGGTDS
VIDVEDLGNIMGRMTKAKVLLLEGVWNVHSVNHSGYHLVYFMCQFLQAKLSCLMICALFS
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGE
PIMYPHINQLVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFVEVKGVTY
CGESSASSLTMANVPWHGEVLSFVQELVQLLPDYGIACEHEHSNCLLMAHSKFQVDGEWR
TWIDYGRFQELVREHERSGGARTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKAR
DTSGC
>A0A135VIH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thorarchaeota archaeon SMTZ-45|TrEMBL
MNSDMPIELSEKLEKQGYHLLGSRGAYKACQWQKKALLHDTSCYKQRFYGIQSHQCLQMT
PVVDKCTQSCEFCWRITPSDIGVSWNQIDVSISDVMPVKELMDAVFMANLRSLGGYNPEV
NAMVPERKYKEARDPKHVAISLAGEPTLYPLLSDLIDEIHQRGMTSFLVTNGTQPDVLST
MSLPTQLYVTLAAADESTYKTLCRPGLRDGWTRILKSQETLQSLSTRTVNRLTMVANRNM
HNERAYSRLIEIGEPDFIEVKGYMFLGSSRGRLDQNNVPTHREIYAFSERLAALTGYYLL
DEQVESRVVLLSRSKQIKKL
>A0A0W7TIQ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilus sp. 1R26|TrEMBL
MDEEYRQTLIRQHYRVYRDHAAVKLCGWIKESLLHGRHCYKQDFYGIMTHRCLQMTPAIN
ECTHMCPFCWRTEGHDYPVTEWAEPKEMLDALIEYHRFLLSGFKGDPRCDPKMFEEAMNP
NQVACSLAGEPTEYPYLSEFFRECRSRGMTVFLVTNGTNPERIAALDTLPSQLYVTVAAP
DRETYAKACRPKISDGWERIKETLALMPSLETRTVIRHTLVQGINMFRPEDYAKIDKTAD
PDLVEPKGYVFVGGSRQRLTVDAMPSFEAVKDFSARLGEELGMSLLREKKDSRVALLGYE
GTELDTARAWESGTAFSRRLH
>A0A6P7DG80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ovis aries|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNLQEKTTPKASQD
LMTNGYVFRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLDLPVAVINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGERKRCRGNCKKGKCESNQRSSEAMEPGSRAQEELHHGDAEEEEPFGSTSEEESD
TEDHQSQNSVIDVEDLGKMMDHVKKEKREKELQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKGERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKGF
RTGG
>A0A7K6J4X0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Machaerirhynchus nigripectus|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVGEDLLQELGA
DKLENGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALSEAVASLNLPVEVVNMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTR
LQALCKGEKNPCSGKCKKGKCKSSGKQSKESSDHEHGMSEHENSEAEELFETSSEEEAGG
TDSVVDVEDLGNIMGHMKKAKVLLLEGVWNALFGSEEVSGTCRHLGVDFLGCLMIFALFS
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALSVKHCALSLVGE
PIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
>A0A7S4KKS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Guillardia theta|TrEMBL
MVLMMERRRRRREEEEKAAQERSLKQADSSSREDVLNAIGDMLTPEAMAPFLGEEEKQQE
VEPKEDRGQAPERVEERGCCQSSNGEESHACACQEQSSGENAARSRNLGLPKKEYIRMKK
AGLLPQRVPKKNAQEEKSKHGNERSAEGTMIICYGSQTGNAENFAKDLYEDASEKGFKVG
IISLASPDFLEKARHALDSSPVFVFITSTWTDGTPPPSCSSFFSWLQQDSCKLELDFNNV
KFTVFGLGNSEYAANFCKAARDLDDRLVALGGKRVCARGEEDDYSPSIFGSWKDSLWVSQ
GARLMGNSVQFIQEDSDEESTSSAQEEDDLDDMLQGEEGGTCGSKADLEDLEDLGKIASR
GKEEKEGVVTLRGKPKKMLNPSLEASLTKQGYKLVGSHSGVKLCRWTKSMLRGRGGCYKH
TFYGIASYQCMEATPSLACANKCVFCWRHHKNPVGTSWRWETDDPQFLVDGFVSKHRAMI
KEMRGLPGVIPERLEEADTVRHCALSLVGEPIIYPHINKFINLLHEQSISTFLVSNAQFP
SQMENLVPCTQLYVSIDASNAEELKAVDRPLFSDFWERFLECIDILDRKGQRTVFRLTLV
KSFNMSEVEGYANLIRRGRPDFVEIKGVTFTGGKKPQLGMSNVPWHAEVVSFASQICKMV
DDEYEIASEHAHSCAILLANKKFKRGSDWYTWIDYPKFFELVRSGQPFTSLDYMTKTPEW
AVYGRGIPGDGGFDPAEIHYRKGDSRTSTPMSSRPDTPSSMR
>A0A8B6ZXU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orycteropus afer afer|TrEMBL
MSLWINRFYIYLGFAVGIGLWICVQIVIKKQGKNSQEKSVPKVPWDLMTSGSASNQKKDV
FVSEVKIFYGSQTGTAKGFATVLAEAVTSLGLPVAVINLKDYDPDDQLVEEVSSKSVCVF
LVATYTDGQPTESAQWFCKWLEEASSDFRFGRTYLKGLRYAVFGLGNSAYSSHFNKVGKN
VDKWLWLLGAHRVLTRGEGDCDVIKSKHGSIEADFSAWKTKLVARLQELRQGEKKPCGGS
CKKGHCESGQHGSERRESPPHRDTEEEVPFESNSEEECGAEERHSLNPVVDVEDLGNIVD
RVKKEKKQQEWREERSRLLRSTEEKEDGEGRAMITPALREALTKQGYQLIGSHSGVKLCR
WTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDRP
EMILKEAIENHQNMIKQFKGVPGVRADRFEEAMKVKHCALSLVGEPIMYPEINRFLELLH
QCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKDSLRKIDRPLFKDFWQRFLGSLKA
LAEKQQRTVYRLTLVKAWNVDELHAYAKLVAIGNPDFIEVKGVTYCGESSASSLTMANVP
WHEEVVRFVHELVDLLPDYGVACEHEHSNCLLIAHKKFKIEREWWTWIDYNRFQELIQEY
ENSGGSKTFSAKDYMARTPRWALFGAHERGFDPKDTRYQRKNRSKDISGC
>A0A2T5M3Z2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus ochraceoroseus IBT 24754|TrEMBL
MAESSTAEEGVLAFWHSFRLPILVALTTVIVIIRLRRKTQARRLKAATASSVPPSPRSSA
PEKTIEKHEVPAVSEKKELKGPDRTAVTGKPAPGPKRVSGRKPQKVAGRRADTTDQEPAL
TFLQPIIFYASLTGNTERYAQLFLEDLRAAAQSQSDSENRERGLLPPQMHDLAYVDFDDY
FTTAPKPPSTSPGTRYIYCFLIPSYNIDTILNTFLAHLDETHHDFRIDTGSLSTLAGFTV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTDKKRAYPLGFGDVKSDAESALKEWSRGLQ
EILGDIVEHGGLGEGVPGSGDPLESDEEDLDDEETDDAKQKARPRRKPRAVVDLEDIKMG
SNSQAGSGSPIPVDFTTSGNPAVQSIQPTEKEMVPTTSPTYAALTKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVD
SPELIFNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINGFLDL
LHSEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCL
DILREKRHIQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAG
LTMQNVPFYEEVAQFVVSLNKELERRGLDYGIAAEHAHSCCVLIASRRFHVDGKWHSRID
YPRFFELLEQEKADGTSFRPEDYMKETEEWALWGNGGFDPNDERVHKRGKKAALQRALEA
>A0A0F8DI68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 2.H.T.1A.3|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFYIPDFATLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPSMLAKINPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDFMK
EKSSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISYLD
>A0A8C8XRD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panthera leo|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDQQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVTLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGLANFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>M0IY08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula vallismortis ATCC 29715|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVRAFTQEMGEYLPNHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWQQDALVEY
>A0A8J7NB42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeota archaeon|TrEMBL
MIPDDLRKLLVRQHYQLVGDHSAVKTCEWLRKSLRGQGVCYKQQFYGVESHRCLQMTPAV
SHCTQKCLFCWRPVEWTLGTELKEYDDPDYIVEGSIKAQRLLISGFGGFEGVDKKKYKEA
QNPNQAAISLSGEPTIYPELGGLIESFHKNGFKTTYLVTNGTFPKVLSSLSREPTQLYLS
LEASNEDLYERLDRPIIKDGWSRLNETIDLLPSLKARKVIRITLIRDWNLSDGLIPEFAR
IIGRAEPDFVECKSYMCIGYSRKRLTLDNMVRHEEILDFSKKLSEETGYKLKDSKEDSRV
ALLSNL
>A0A6G1YQB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSDEHASHVTQDSLIQISPAVKSRLQKAKYGVYNHSAVELCHWTKKSFANAGNCYKHK
FYGISTHRCMEMTPTAMNCENRCVYCWRPTEFYDTLQMPPELVDEPDVIVEHLMAERKKL
INGFYGHEKNDRKKLDESLFPVHYAISLSGEPTMYPKLPQLIKYLRRLPATKSIFLVTNG
QEPEMLQRLADEDSLPTQIYLSTNASNKRMFYLVNRPRHRDAWERWWKSLRFLSTANTRT
VLRMTLIRQYNDATKFIDEFAEMMQQGNPHFIELKSYMHIGMSTQRLEAENMLEMKEIRS
FSEQMCFKLHDYSIMDESEISRIVVLQNLRRYTDRWIKEYSIEA
>A0A843AZ75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccus sp|TrEMBL
MTTDLNRAREKQQYKMHGGHAAVKLCHWMQQSLLKDRPCYKQEFYGIRSHRCLQMTPVVD
QCTHNCLFCWRVQGFDRKEEDWREPEEILDACIAEQRKLVSGFKGDPRCNKEMWNESREP
KQVAISLSGEPTMYPYLGDLIALCHRRGMTTFLVTNGTLPEVLEQLDPLPTQLYVTVAAP
NPEVYKRLCVPRIPDGWERLMRTLELFPSLDTRKVVRHTLVKDWNIGWEDDYAKLDSIAD
PTFIEPKGYVFVGDSRRRMSMSNMPSFAEIREFSAKLGERVGMNILKERKDSRVLVLGED
EKELRIPGL
>A0A8B8MX00|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhodamnia argentea|TrEMBL
MYPSSLSARITLLALFSASTFYFIYKSRRRKDLPLVSFNPNGDSGSDDLSRRRGKLFFVS
QTGSSRALARRLFSLLASSGLPFDLVDPQSYEPEDLSKESLVLIVASTWEDGKPPENGRF
LANWLAESAADFRVGSLLLSRCRFAVFGVGSGAYGAHFNAVAKDLSVKMRALGAGEILPL
SLGDVDKGDVDGLFDIWSEKLIAVLKGGEDSGVVLESGVGTGGESENESDGGFESDEDGG
SSGESVVVDLEDIAGKGPSRKSGAAAQINGKANGTREMVTPVIRTSLEKQGYKIIGSHSG
VKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQW
KMDDPLEIVVTAIELHTKMIKQMKGVPGVTQERLSEGLSPRHCALSLVGEPIMYPEINAL
VDELHRRHISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFGNFWERFI
DSLRELKDKQQRTVYRLTLVKGWNTEDIDAYSNLFSIGKPDFVEIKGVTYCGSSATSKLT
MENVPWHSDVKAFSEALASRSKGAYEVACEHVHSCCVLLAKTDKFKVDGQWFTWIDYEKF
QVLVASGKPFDSRDYMAATPSWAVYGADEGGFDPDQLRYRKERHHKSNR
>N4U6P3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. cubense (strain race 1)|TrEMBL
MDWANYSPPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEAVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A7J3QBE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MFNTLKKQGYHLIGSHAAVKKCLWVHNALVYNKFCYKCRFYGIESHRCVQFSPAVSWCWN
SCLHCWRARPFDYGLEGPELIRLPYVEDPEFLAEMAILEHRRTVSGYAKRTSREMYREAI
DPKHVAISLTGESTLYPRLGELIEVFHRKGLTTFLVTRGVRPDVLSNLEEEPTQLYVSLE
TWNEEMYREFNKPAGANLWRLTLQTLELLQSLSTRTVIRFTMIKGYNMRSEDVGGFAKLI
DIANPTFVEIKAYMHVGASIGRLSRSSMPSYEEVMEFAEKLAKATSYKLVSSSRPSRVAL
LTRLEGPVVRYGKGCPKAWEEKDVEGEKYVEEYK
>A0A4U0XEB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cryomyces minteri|TrEMBL
MPDAAELLYLWHTYRLPVLLAAVAVFALVRLTLRARGKREKTATIPPPGSPGPLSKDVKD
GGWPDVLGDSREGKDEVVSVSEQPPTRAKAGPKRVTGVIRTKTSPSRDAGFDLTRDELQP
LLFFSSLSGTTEKAASKLVADLQASTEAAPNVLPPKLLDLAYIDYDDYFIAPPKTSSEKR
SIKYFYLIAIPTYNIDTVLDNFLEHLRETHHDFRIDTAPLSALLGYSVFGFGNKEGWPTE
AEGFCSQAKEADKWMAKLTGRKRAFPLGMGDVNGDAAERFDEWGMGVEDVIRDISAGRGL
GEGVPGSGDAVESDEEDVEDAQDSEGDTQAQPKVQRPKKRADLGDLEDLGRSVQKDPSSA
PITIDFTTYSSSKKPTPVVKEMVPKSSPTYTALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEAIYAGVTA
GHYRKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTALLHADRISSFLV
CNAQHPDQLAALKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFTRCLDILRAKRLTQR
TVFRLTLVKGFNIDDEAEGYADLVARGLPCFVEVKGVTYCGTSTSAAAGLTMQNVPFYGE
VCAFVDALVAALARRSLDPPYGIAAEHAHSCCVLIASTRFLKPDGWHTTIDYDRFFDCLR
AGTAFAPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRPKGPQSVPVGGGGGRVLEVA
>A0A3S3NYZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dinothrombium tinctorium|TrEMBL
SGARCCEQANDECVILFCTQTGNAKRIAEGLQQSLSADQKFCKQTRLFNIKHFDPDDNFT
RFSNSCCNRITLIIIISTYIDGQSPDDGKWFCKWLQEAAHDFRVDKNLLNKIHFAIFGLG
NSEYNDNFCLIAKQIESWFIKLNAIKLIDTGCGDETSFMSLDEQFALWRSKLLNKFINSN
NERHETQTMVNDVRESESDVESPNENLVDIEDLMISRKIKENSDGKAKKEMITPQLRKEL
TKQGYKLIGTHSGVKMCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWKWEMDPPEMIVEEAIKNHCKMIKEFKGVPGVLPERFEEGLQIKHCALSL
VGEPIMYPQINKIIRFLHERKISTFLVTNAQFPQAIQELDPVTQLYVSVDASSKESLKRI
DRPLFKDFWQRFLDSLKALSSKRQRTVYRLTLVKSWNNEELEGYAKLISIGKPDFIEIKG
VTYCGSSKGSNLTMNNVPWHEEVVNFVKLLTNYIDSDYEIASEHEHSNCVLVANKRFKVD
GQWKTWIDYEKFHDLIKKFYETGETFEATDYMTDLPDWAVYGSNEQGS
>A0A1W0X3R9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypsibius dujardini|TrEMBL
MDSTIVDYLTLFIFTIAVGYFVQKYFKRQQLTASGKNTAQSDGSTRSLAEPHDDDLPHTQ
EIGGGDHDAVVSGGGNACTSKKSAKIGLVSKASSVCGCAETETVSCCKTSKHQPADGVND
FSKIRIYHGGQSGTAQKFAEDLRSKLERESSVGGPARWGCDLLDLSSWDPEVFMAKLSPE
VLHVFLLATWTDGEAPKSAEWFTFWLRDTDEDFRISKTHLKQMKFAVFGLGHSSYGEDNF
NKVARTVHRELTSLSAHPVLPLYLGDENVSGSKHGSIRKDFEAWSSALLEKLSSMKSSKS
SSGNSSAELDDVSDQEDPESSDLYETTSEEGHSGEGYESDAENVMDLEDLGSVATKLSDA
KEAKAKRMQEKNSKIRTRRMKPNGEAVVLKEMVTPELRAALTKQGYKIVGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHQTNPVGTEWKWQMDEPE
KILTDAIEGHAQMIKQFKGVPGVKPERFVEGLQPKHCALSLVGEPIMYPEINTLIDLLHA
KDISTFLVTNAQFPDAIRKLNPITQLYVSVDASSKDSLKKIDRPLFRDFWERFIDSLKAL
SEKGQRTVYRLTLVKAFNVDEIEAYASLVALGKPDFIEIKGVTYCGDSKGGLTMENVPWH
DEVVSFVKQIEEMLPEYEMASEHEHSNCILLANKKFKVDGEWWTWIDYDRFQQLVREHAR
TNGEKTFTSADYIAKTPSWAVYGCKERGFDPDETRFHRKNKKDISGC
>A0A024U8M1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces invadans|TrEMBL
MLVVKPSTLAAAATLAVVSASIAYVLWKQRRHENASSKAQSRKASTGCCTNNTTETSTGC
CQNNSSGHNGDDAEESNKPVAVRILYGTHTGTAKGYAVALQKKLFALNVAGYAFEPSVVD
MKDYDQDNLEHEQVLIAILSTWTGGVPPESAMVFCNWVQDMAQDFRVSKTWLKHVHVAVY
GLGNSEYDENFGKASKALSKHFSTLGASRLCPRGVGDDNHDQTAQFDTWSDHLIASLCEQ
YVILQKPATADADARNSKVAGWKSQNEFRRQKRKEKAAANGEDNEEAMWTAEDQMNEIVL
ELDQGDDSDEDGPSRRTKGNGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYKI
IGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPV
GREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMY
PHINEFCRELHARQISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKD
FWERFLSCLTQLKAKGQRTVYRMTLVKEHNMKEIDNYVELIHMGEPDLIEIKAVTYCGKS
DASDLTMQNVPYHQEVRDFCELLCAKLGCGYALATEHAHSNCVLIAKTAFKIDGQWHTWI
DYDKFHSLIQAYYKDGTPFTTMDYIAPTPAWAVYNAPEAGFDPIETRFRRTKEGKVVEIE
YTATDSGCG
>A0A418AHL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces invadans|TrEMBL
MAQDFRVSKTWLKHVHVAVYGLGNSEYDENFGKASKALSKHFSTLGASRLCPRGVGDDNH
DQTAQFDTWSDHLIASLCEQYVILQKPATADADARNSKVAGWKSQNEFRRQKRKEKAAAN
GEDNEEAMWTAEDQMNEIVLELDQGDDSDEDGPSRRTKGNGVVDVEDIGVVMKESEAAAL
SREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETT
PSLACANKCVFCWRHHKNPVGREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRW
EEAFTVRHCALSLVGEPIMYPHINEFCRELHARQISSFLVTNAQFPEKIAALEPITQLYV
SVDAATKDSLKAIDRPLFKDFWERFLSCLTQLKAKGQRTVYRMTLVKEHNMKEIDNYVEL
IHMGEPDLIEIKAVTYCGKSDASDLTMQNVPYHQEVRDFCELLCAKLGGGYALATEHAHS
NCVLIAKTAFKIDGQWHTWIDYDKFHSLIQAYYKDGTPFTTMDYIAPTPAWAVYNAPEAG
FDPIETRFRRTKEGKVVEIEYTATDSGCG
>A0A8B6EFT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilus galloprovincialis|TrEMBL
MLEKLLSSYIFESFQIPVWTLLLATICLIWMWNSGRKNENSSEKVEDQKSTELPITNENV
IELHANSRQKITKKRKIKIFFGTQTGNAKMLADNLCREATERGHEAEVLDLKTYDPEDNL
VTEGENGVWVVLFISTYTDGTPPEGSEWFCKWLEESSTDFRIPKALLKELHYAVFGLGNS
LYTENYNAVGKKVDRFFRELSAKPILPVGLGDENVAESLKGGMEKDFTAWKKEFWKKSKK
VKDNDTVVTDTCGTGKKTCDGKCKCKEDGGKCSSEEEEEEEEGEDLYETTTEEEDNAEEL
LNEDGDGSSLQTTNGVVDLEDLGKVMQTMKKAKVRRKKEESAQSTGEPREMVTPMLKKAL
EKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDDANTVFQGALDNHVGLIKQFKGVPGVKAERFAEGLEPQHCALSL
VGEPIMYPEINKFIELLHGKGISSFLVTNAQFPDAISNLVPVTQLYVSIDASTKESLKKI
DRPLFKDFWERFIESLKALSAKRQRTVYRLTLVKAWNTDELDNYADLVSLGKPDFIEIKG
VTYCGESKASSLTMQNVPWHEEVVHFVKQLTDRLDDYEIASEHEHSNCILIANTKFKVDG
EWWTWIDYPKFHQLIKDFNESQKTFSAEDYMAKTPQWAVFGAKEQGFDPVETRFFRKKQK
DIGGC
>A0A2I3TFD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pan troglodytes|TrEMBL
LDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIE
ADFRAWKTKFISQLQALQKGERKKSCGSHCKKGKCESHQHGSEEREEGSHEQDELHHRDT
EEEEPFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDSERRAMITPALREALTKQGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEP
IMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKIDRPL
FKDFWQRFLDSLKALAVKYTLRYLINASIFFLETGSCSVTKARTQWHHHSSLEPPTPGPK
RSSCLSLPSTGTTGTYCHA
>A0A446UNS7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRTLRPSPSPSSSPAPAAAAA
PTLLYASATGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGA
PPPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALG
AVEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYD
DDDEEEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLEK
QGYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVG
EPIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDR
PLFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVT
YCGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKING
KWHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAA
LKG
>A0A7K4XZY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Regulus satrapa|TrEMBL
LDVPMDTWSYFQTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTSRTKKKVTEPGTADKLG
NGCVPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPEDGLA
EETSSKNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRTEGDCNVAQSKHGSIEADFETWKAKFLTRLQAL
CKGERKSCSEKCKKGKCKSSGKQSKETSDHEHGTSEHENTEAEELFETSSEEEAGDTDSV
IDVEDLGNIMGHMKKAKVLLQSRYHLMYFVCKFLQDKLNFLVICALFSGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKM
DQPEVILQEAIEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINRFVR
LLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDS
LKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMA
NVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWIDYGRFQELI
TEHEHSGGSRTFTAADYTARTPPWALFGARERGFDPLDVRFQRKNKARDISGC
>A3MUH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)|TrEMBL
MCCAVPLDKLIYRERGLPVSCEVEPIGRYHVLEGPRIKIRASAGRALVERHYGFVGHAAV
ELCKWTREAIEGGKSCYKVKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDAFV
LDERFYLEPEEIVRGVLKERVRLLSGYWGHPEGKRRVKEALAPTHWAISLSGEPTMYPKL
PELIKLIKSLPETKSVFLVTNGQHPEMIKRLWEEDALPTQLYLSTNAPNKELYYRVNVPV
YNREDAWEKWLQSLDLLAVVPTRTVMRITLIRSLNYDERYIPQFAELVKRGNPHFVEVKS
YMHLGHSTFRLKREDMLSHEEVKAWAYKLLEELRRIGADFVYMDDDEPSRIVVLQNMKRY
VDRWIVPPASGNGSAPRSSK
>A0A814W8D4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTVDLYILAAGSALTGLVFYFFAGAEWSLWHLFTIPLYTFVFIVFLSLSIIKRFKSSSKP
SESLTKIIPQEKNGITIVFGSVKGNCRTFAQSTYDKLSNELNCQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDGTPPPSATWFVRHLQEAATDFRVSKNELEKLTYAIFGCGNS
FYDDNFNKVATELDRCLSELGAKQFIPTELADENSGKSIYGGLEGHYSKWSSQLKSAFQS
PKTEKCDCSNENSISCCQSSTNNDHSIEKKQNGEQSRIESDDDDEGGGCKDGDDDIMDLE
DMGDYMETHSPNKTAKGPPKEMITPIIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVDGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A1G8TL71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halovenus aranensis|TrEMBL
MSDSEGGPKQVDDPSYHNDNHTAVQTCGWTKNALRGEGKCYKNIFYGIESHRCVQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQTKLLSGFGGNEEVPRERFDEA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTKPEVLADCDPTQLYVSVDA
ADRKTFDETVKAVDDDAWERLIETLDVLAEKDDTRTVIRTTLIDGHNMHHPEWYAAMCTR
ARADFIELKAYMHVGHSRGRLDRDSMPEHEAVVDFAEQLQEYLPHDELKQVPASRVAMLA
RDGDTWVPKLKKSSEFWERDPLAQ
>A0A7C5LFN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldiarchaeum subterraneum|TrEMBL
MAQTIRIAVVEKPVRREVKQAEKFRQAGYRIVGNHSAVKVCHWTKSALRGGKMCYKSWYG
IESHRCIQMTPSLQYCNMMCVFCWRFHTLNRVQPFDGGWDEPSKLLDMIIAEQRQLLSGF
GGNPKVSKKRFIEALTPKHMAISLDGEPTLYPYLADLIQEASNRGMTTFLVTNGTMPERL
EELFEKVQPTSLYISLYGPDKETHIKTCKPLIPDSWERLLKSLELMAKFSCRKVIRLTLV
KNFNMHCPEKYADLIKLASPDFVECKGYTHVGESQLRLEKTNMPSIEEIRMFAESLAGSL
SYEKVVEDDVSRVVLLANPSSRYYLDVVTRLNRI
>A0A4W6CX79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
PVPRHEPSPGESYFMSIWHNRLYLYSAAALVFGSWFAVKMALKKVSCLLLISPLHLDSLF
VQGFAVELSEEVKTLGIPAEVTDMKDYDPDDQLADECTSKSICVFIVATYTDGQPTENAE
WFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHFNTVGKNVDKWLWMLSGMRIMT
RGEGDCNVVKSRNGSIQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGTCKNKRKDRQ
VMEEEKAALQNVSSEVSELSSSVFLHGTLKEEGRGDGQMVKLSKLNGVKKIEDEGERREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQFRGVPGVKPERYEEGL
AVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLEPVTQLYVSVDA
STKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALG
QPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLI
AHTKFKVEGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPSWALFGASEQGFDP
ADTRFQRRNKTKDISGC
>A0A4W6CX55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDPDD
QLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLG
NSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRL
QALAKGEKKSCSGNCKTGGTCKNKRKDRQEELIESSSDEDESGLQDEKKSGSVVDMEDLG
NIMNSAKKRCLLSESLILLTCCSLSFPAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTF
YGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQ
FRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQE
IRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKA
WNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLP
QYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAK
TPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>B2B2W3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)|TrEMBL
MLCSPHIVDAVDLWHEHRIPILLSTAFILTFLRFYLRLNDAQSEQQKLGDASKRVKKEGG
EAREGFKFWSLFSCLTGSTEKIAKQFAGAFKEALTKAKGEQTTFLPPQVLDLSEVDYDEY
FISPPKTEGEEKVDYFYLILLPSFNIDSINDTFLEHLQETHHDFRIDTSPLAPILGYSVF
GFGDREGWPTEEEGYCFQAKEVDKWMAKLSGRKRAYPLGMGDWKRDGKERLAEWKSGLVD
VLGQIEQNGGLGEGIPGSGDPIESDDEELDDDGEVYDESAEQNGKSKSSGDLGDLEDLGQ
IMAASGNTGKKSSGPIAVDFTTEGKPKRKAAAPAVIKEMVPKGSPTYNSLTKQGYAIVGS
HSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTN
WRWVVDPPDLIFNGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHI
NEFLGMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKESLRRIDRPLHRDFWE
RFNRCLDILRERRFQQRTVFRLTLVKDFNLEDEVEGYADLVQKGLPCFVEIKGVTYCGTS
TSSSAGLTMQNVPFYNEVCDFVVALEKALKKRGLNYGIAAEHAHSCCILLASDRFQKEGK
WHTRIDYERFFELLEERGPDGEFTPEEYMGPETPEWATWGRGGFDPRDQRVDRKGRPVEV
S
>A0A194USV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Valsa mali var. pyri|TrEMBL
MEFEPFGVSPWLAQLSDSAVEYWHANRTAIILAALTILIVLRLYFHFTEGTEPLHVFPKI
YDAEDKPVKVEEKVEVVTRNKPDGPRRIKGELAKRRSTEVDTGRRQIKTLIFYSSLTGNT
EKTAKEFVKTLAGLLEGVTTSSTCAFSQPEALDLAELDLDEYFITPPKLEEQEDVTTDLF
YLFLLPSYNIDSINDTFLEHLNETHNDFRIDTAPLAPILGYSVFGFGDKEGWPTEEAGYC
FQAKELDRWLAKLTGRKRAYPLGMGDVKSNGTQRLSEWTNGLLDVLGQLARDGTLGDGVP
GSGDAAESDDEADVDDDDGEVVFEDDSQPKSTKPKSSGTLEDLEDLGRILQNAKDDGAKP
AAPLAIDFTTTTSKRKQPVQAVKEMVPKNSPTYNSLTKQGYSIIKMMRGVPGVRAERFAE
AMRIRHCALSLVGEPIFYPHINEFLEMLHGDRISSFLVCNAQHPDQLAALNHVTQLYVSI
DASNKESLRKIDRPLHRDFWERFQRCLEILREKRFKQRTVFRLTLVKGFNIEDEAKGYAD
LVEKSLPCFVEVKGVTYCGTSTSSSAGLSMANVPFYEEVCEFVTALERELKRRGLNYGIA
AEHAHSCCILLGSERFKVDGKWRTQIDYDRFFDLLEERGPDGDFTPEDYMGAETPEWATW
GNGGFDPRDQRVDRKGRPIER
>A0A8H6NXR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum musicola|TrEMBL
MALPNDQMGFKAMLNNAHDAWQEIRVPVILFTAFGLFILRFYLHSTEEKSELKALPKVLG
REKKPDTKSKPVEEKKDAKLKSAPTPVPESKAAKSNGPKRIKGGLVKRPSEELKDGELLA
RRIRPLVFFSSITANTPKIAKEYAERLENELQKTAADTGCSFTTPEVLDLAEIDFDDYFI
TPPKTEDPVDLVYLFLLPSYNIDTINDTFLEHLKETHHDFRIDTAPLSPLLGYSVFGFGD
REGWPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYKERLAEWSEGVVEVLGM
LAKTGSLGEGLPGSGAPEESDDESAAEDDDEVLIEDAEAKPEKLKSRKNIDDVEDLGRIM
KNSQPDTEVKSTSAAPIAVDFTTYGKSATQKKTPTQGPKEMVPKNSPTYASLTKQGYSIV
GSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVG
TTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYP
YINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDF
WERFQRCLDILREKRFKHRTVFRLTLVKGFNVEDEVEGYAQLVEKGLPCFVEIKGVTYCG
TSTASNAGLSMSNVPFYWEVADFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKD
GKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKI
EA
>A0A843HJB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp|TrEMBL
ETKKKDMEKKGYRFAGQHLHSGNKICHWTRKSIVDDGVCYKEEFYGIKSHRCLQMSPAIP
YCQHKCLFCWRDTEITKTSWDSDDYDDPKTIIEDCIANQKQLLCGFFGNENANPQKLEEC
IMPNNAAISLAGEPLLYPEINQLLREFEKKDFTTFLVSNGERPDLLKKLEDEEPTQLYIS
LDAPNKDVYRKVCLPQVENGWEKLNESLELLSTLDTRKVLRITSVHQLNMLNTEEYAKII
DKTDIDYVEIKAYMFVGDSRNRLEWENMPTTQQLHDFAYDIADKSGLDVINEVEKSRVLL
LGDKLPTKYNN
>A0A4D6KCG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicrobium mukohataei|TrEMBL
MSESDGPKQVDDPDYHSENHTAAQTCGWTANALRGEGKCYKYIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVQWDDPSAVADASLELQKRLLSGFGGNEKVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFHDRDITTFLVSNGTNPDVLDRCDPTQLYVSVDAP
DRKTFDDTVKAVEDSAWDSLIDTLDVLADKDDTRTVIRTTLVKGHNMHHPAWYAAMCQRA
DADYVEMKAYMHVGHSRGRLDRESMPSHDEVRAFTEEVGGFLPEHDTMKEVEESHVTLLA
REDETWVPKLEKSSEFWERDPVVSY
>A0A7C0ZZM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
MSKLRFNNNVTRRYLRAGYRLVGRHSAVEICRWTKSALKGERLCYKRWYGVRSHRCVQMT
PNLNFCNFACVFCWRMHLPGRFKLPEGWEWDKPEDIIEGAIQAQRELLIGFKGHPKVTRE
RFLEAMFPRHMAISLDGEPALYPYLAELVKKVKERGMTAYVVTNGSVPYRLQEMLKKEAQ
PTNLYISVYGPDEETFRKAARPLISNAWKFVQESLELLSKFSTRTIIRLTMVRGLNMVNP
EGYARLIERAQPRFFELKGYTWVGESQKRLPISAMPTIDELREFGDKIAEKTGYLLKEVD
TKSRVVMYVRDEETWEWNLKLVEEWRKLEEKLDREQWKGKITDFKLKKR
>A0A669CD42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis niloticus|TrEMBL
MCFLPPVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKKVRHLLIPYSNLCLET
KEVHVSGVKIFYGSQTGTAKGFANELSEEVKALGLPAEVIDMKDYDPDDQLADECISKSV
CVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTV
CKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSIQADFLAWKVKFLNRLKTLAKGEKKSC
SGKCKTEGSCKNKRKDRGDIQPEPRGAENFAKCPSSCFLLLPSKDIDVYMAVDHNRLKVL
FLPQSKEESQRDGQMVKLSKLNGVQKIEDEGERREMITPALREALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPAEKILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINNFIR
LLHHHQISSFLVTNAQFPQEIRYKSLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPRFL
DSLKALGEKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLT
MANVPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQE
LVQAYDESGGQQTFSALDYVAKTPSWALFGAQEQGFDPAETRFQRRNKSKDISGC
>A0A2R6HRR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_4_62_28|TrEMBL
MSESDGPKQVDDPDYHSENHTAAQTCGWTANSLRGEGKCYKYIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADASLRLQKKLLSGFGGNDKVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFHDRDITTFLVSNGTNPDVLAECDPTQLYVSVDAP
DRKTFDETVKAVEGGAWESLIDTLDVLAEKDDTRTVIRTTLVKGHNMHYPAWYAAMCDRA
NVDFVEMKAYMHVGHSRGRLDRESMPSHDDVREFTERVGQFLPDHDVMKEVEESHVTLLA
REDQTWVPKLEKSSDFWERDPVVNY
>A0A3P9Q137|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia reticulata|TrEMBL
MVSSWLCLSLSDTWIPQDVHSPTENYLLWMWNNRLYVYSAAALLLGFCFLLQIKHTKDSG
SKDSGPKVQKAAKNKISSDEDADVHVSGVKIFYGSQTGTAKGFASELSQEVQTLGIPAEV
IDMKDYDPDDRLADECVSKSVCVFLVATYTDGRPTQNAEWFCKWLEEASTDFRYGNSFLK
GLRYAVFGLGDSVYVGHYNTVGTNVDKWLWMLSARRVLSRGEGDGNVVRSRHGSVQADFR
AWRVRFLSRLRALAGGEKKSCSGNCKSGASCKNRKKHGAQEEEEEEHGSEVELIESSSEE
EESGWRDEKTSRSVVDMEDLGNIMNSVRKAKLILCSAVVSGIFAHQHVLPPSGYKLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEW
RWKMDPAEKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLAAKHCALSLVGEPIMYPEIN
TFLRLLHSHRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPR
FLDCLRALGEKKQRTVYRLTLVKAWNVEELQAYAELIALGQPDFIEVKGVTYCGESSASS
LTMANVPWHQEVVAFVQQLADMLPHYQIACEHEHSNCLLIAHNKFKVNGEWWTWIDYDRF
QDLVQAHEDSGGQQSFSALDYTAKTPSWALFGSNEQGFDPADTRFQRRNKTKDISGC
>M3WKD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Felis catus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDESVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKELQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>R9T7B4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccus intestinalis (strain Issoire-Mx1)|TrEMBL
MNDVTETLKKQQYKLHGDHAAVKLCHWVKQSLLHDRPCYKQEFYGIKSHRCLQMTPVVNM
CTHNCLFCWRVQGFDSENIAWKEPEDILEHCLEQQKKLVSGFGGDPRCSKEMWLEAREPK
QVAISLSGEPTLYPMLGDFIELCKRRGMTTFLVTNGTTPEILEKLDPLPTQLYVTVAAPN
EEVYKRICVPRIPDGWEKLMKTLELFPSLNTRTVIRHTLVQGWNVGWEDEYAKLDETADP
MFIEPKGYVFVGDSRRRMTIDNMPSPASVAEFGKRIASRLGMELLRERPDSRVCLLGDKN
AQVKIPGLE
>A0A7K7BBP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothoprocta ornata|TrEMBL
LDVSMDPQNYFYTCLVSLWLHRFYIYSSLALGISVWICIQCFANKTRRKKCNGNPASAEE
TEGKLVNGYATSKAKEVYVAGVKIFYGSQTGTAKRFAESLAEAVISLNLSAEVINMGDYD
PDDSLTEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVSDFRFGKMYLRGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSRHGSIEADFEAWKTKFL
SRLQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDHGHGTSEYVNAEAEEFFETTSEEES
DAEKAGDSNSVIDVEDLGEIMSHVKKVKVLLASTEDMMVLSFVLGGALGFSSRFLPNQNS
YKLLGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRLEEAMTAKHCALSLVGEP
IMYPEINRFLKLLHQQNISSFLVTNAQFPQEIRNLEPVTQLYVSVDASTKESLKKIDRPL
FKDFWQRFLDSLMALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYC
GESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKINGEWCT
WINYDRFQELAQDYERSGGAKTFTAADYMAKTPHWALFGAKERGFDPLDIRYQRKNKTKD
VSGC
>A0A7K6Y8Q3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alca torda|TrEMBL
LNVSMDTWNFSYPCLVSLWLHRFYIYSVVAFGISVWIIIQFLTTKTKNKGEKSNGSPASS
EGIKDKLLNGYATLKAKEVYVAGVKIFYGSQTGTAKKFATGLAEAVISLNLPVAVISMGD
YDPDDCLAEETTSRNICVFLVATYTDGQPPESAAWFCKWLGEAANDFRFGKTYLKGLRYA
VFGLGNSVYVDHYNTAGRNIDRWLWMLGASRIMTRAEGDCNVAQSKHGSIESDFEAWKAK
FLSWLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDQEHRASEHENTEAEELFETSSEE
EADAEEAGGTNAVVDVEDLGNIMSHMKKAKRERELEEGDVGTSLTRENAGRKEEGEKREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLM
AHKKFKVDGEWCTWINYGRFQELVREHERSGGAKTFTAADYAAKTPRWALFGSRERGFDP
LDVRYQRKNKARDISGC
>A0A836IE64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania sp. Namibia|TrEMBL
MIGCALQLLVSAGLTFVAFLLFNCLADSAHARGNVAVSDTDAAGNADVFSRQVRAELEQL
GVASAPPTAGPVQSAPPPAEKTPSPAAAAAVEILIAYATQSQNSLALAHKLFSLITAQLH
TSPMRTAEAAVCPLVRVMEMREEDSNGSGATAVDSGGRVGSKNVCRVDTLLEENRYALII
FIVSTYTDGLAPPRSRVFEAMLRDAFEDHRVPRNALGRKRFAVFGLGDIAYGEARFNAFA
KNLHEWCRGLGAPPFVVPPVYATEAKAQSLFRIFSTALLKWVSRATFHSDGTVTVQKKSE
VAVTGSAAAGATGVRSRRPRSVAATSTANASMTSAAAGEALGNEGVSCACQQSSGQSCGN
GAGAGGEESCGCCEAEPARNGVAASKSDDDDDDANAEKDSMDDVEDLVWDGTDDADFDIN
KDPNELPELIYPKLRQSLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQ
CMEMTPSLACANKCIFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGV
TPERLAAAMQIRHCALSLVGEPIMYPQINRFCALLHQQHISSFMVTNAQFPEQLRDLKPV
VQLYLSIDAPTPEELKQIDRPLFEDYWDRCLSCVKELAKKRQRTVFRLTLVNQYNTDNVK
AYADLVEMGQPDFIEVKGVTYCGTSPSSTLNMKDNVPRHDQVMGFCKALCAEMASRHPHY
RTPQMDGDEEGGDDVIVIPAEERDRPYHVACEHEHSCCVLIALDKFFFGGRWHTWIDYER
FYDLVESGRTDFTSLDYAAVTPAWATCNSKEKGFDPEQTRVVRKNGRPTIVTASC
>R0IAF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capsella rubella|TrEMBL
MSATSSLRARLAFVALLSATTFYCIHKYRRLKRLKNLSLNPSSTSKPARGKIFFISQTGT
AKALAERLHELCASNEIAFDLIDPRSYEPEDLPKETLVIFITSTWDGGKPPKNGEFLVNW
LGESAEDFRVGSLLLSDCKFGVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEGD
VDDGELDKAFQEWCDGVIRVLKGGSVQETNGVSHQNGAVENDLEYYDSTDDEDEDNDEDG
GIVDLEDIAGKAPSKRNGIVKVTKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSV
IVKGALDLHTKMIKQMKGVPGVTAEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGR
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALH
EKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGTSATSKLTMENVPWH
ADVKAFSEALSSKSKGEYEVACEHAHSCCVLLGRTEKFKVNGKWFTWIDYEKFHDLVASG
EPFTSSDYMAQTPSWAVYGAEEGGFDPEQLRFKKERHHHPKPQAVLA
>A0A6A5UXF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bimuria novae-zelandiae CBS 107.79|TrEMBL
MLLDRLLVLPNELLLLWHNHRVPLLLSALSLAIIVHVIVYLRSRRQKVLVSPPPSSPVEK
KEIELRPEWLPENTTIVVPALNVDNHADDVAVPVPVIKVKKGPKTVKGKKVPKQRTPPAS
NFDHKTDKIQPLVFFQSLSGTTECYATQLAKTLTEWTVGCDQSASLLEPQTHDLSYIEYD
DYFLTPPKADSNTKHFYILLLPTYNIDTVLDNFLENLQETHNDFRIDTAPLSGLVGYSVF
GFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGIGDVKSDVDARLGEWRAGVQE
ALVELAEGRGLGEGVPGSGDPAESDDEDEDVAEDSDGEGITSKPRKATRVDDLEDLGSMV
NSESPNPIPVDFTSYKSKASKPVSAPKEMVPVTSPTHAALTKQGYSIIGSHSGVKICRWT
KSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDL
IYDGITAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLAIMHAN
RISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILK
QRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQ
NVPFYEEVAAFVTALAEELSKRGLGYGIAAEHAHSCCVLLADERRFKKNGRWATRIDFER
FYELNEGLVEGTRTDEQGRVVGWRPEDYVGEETPEWALWGNGGFDPRDVRVWRKGKGPKG
ENNVEGTKEDVKVVEI
>A0A3Q3JK57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monopterus albus|TrEMBL
MPSFFVVFLLFVRCASTSDIKASQNGHSPTESVLMSMWHNRLYLYSAVALIFGIWFSLKL
VLKKKSLSKNDRLKTYKTVKNSDRSHADTVAHVSGVKIFYGSQTGTAKGFARELSEEVNA
LGIPAEVTDMKDYDPDDQLADECSSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGRRIMTRGEGDCNVVKSRNG
SIQADFLAWKVKFLNRLQALAKGEKKSCSGKCKSRGSCKNKRKDGHVEEKKAALQSNSSE
ENVMESSSDESESGPQDDKTAGSVVDMEDLGNIMNSIKKAKSREEDQVDGQMVKLSKLNE
VTKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQHMVRQFRG
VPGVKPERFEEGLTVKHCALSLVGEPIMYPEINAFIRLLHSHHISSFLVTNAQFPDEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFQDFWSRFLDSLRALGEKRQRTVYRLTLVKAWNV
EEIQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANIPWHQEVVAFVQQLVDMLPQYE
IACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFLELVQADEESRGQQTFSALDYIAKTPS
WALFGACEQGFDPADTRFQRHNKTKDISGC
>A0A315Y8V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter thaueri|TrEMBL
MSFNKEQIEKLEKSGYRFVGTHGHAAVKTCHWTRQSISDKGVCYKEKFYGIKSHRCLQMS
PSVPNCQQECEFCWRDLTYTQTSWEDDEYDDPKTIVDEAIKAQNNLMCGFYGNPNANKKK
LEEMKNPNNAAISLAGEPTLYPKIDELIGEFNRRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPSKKIFEEVCRPRINDAWDNLNESLETLASFNSRTCIRNTCVRGKNMENPEEYA
KLIKKANPDYVEVKAYMYVGSSRERLTMDNMPSFDEVKEFAKKIGENCGKEIVNESQVSR
VVLLE
>A0A3M7EZ26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKSAASQEAQLIEKIQPI
IFYYTLGGSTKVYAESVAQNFATSSPSSILEPQLHDLADTEYDDFFLSIPKAEKTAYFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGYCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKVEAENMLTEWTEGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDDTPAPRKSKRKPAKRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRYTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALAKRG
LDYGIGAEHAHSCCILLADRERFYRVPEAEKNNPLAEKKWHTLIDYPRFFDCLESGKPFS
PEDYVGPPTPEWALWGNGGFDPRDERVDRKGRPKEPKVQEVQE
>A0A4Z1L4R4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis porri|TrEMBL
MAYGSWISRPIWSYEIDDIVALWHLYRIPIILTTATILILVRITLRPRTVREKLSASPLP
SSPLLPAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPQKIQPLVFFSS
LTGTTEKTANAFVESIRGDLSGRANGQRIQFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGNLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKARTQKKDDSLNDLEDIGGVLNNTETID
NTTGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DQPEMIFNGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPEIQGMI
MGEVQDGGEDKVAENSTKDDLAF
>A0A7J4DTJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrodictiaceae archaeon|TrEMBL
MGWCEISQFTIRTIRGKFWKLKIDDFPEPYRSLYMLLKKQGYVLVGRHSVVKKCHWTHMA
LTQKRFCYKCKFYGIASHRCVQMSPSALWCWNACLHCWRARPQDIGISWDETKLLWVDDP
EYIAKGSIEAQREILSGYKGHPKIDPRMYEEALNPKHVAISLTGEPVLYPRLGELIEVYH
KMGMTTFLVTRGVRSDVLANLDEEPTQLYISIEAWDKKSYEYFNKPLVPKAWELTLETLQ
LLPSFSCPTVVRITLVRSFNMHEEALKGFAKLMEIAQPTYIEVKAYMYLGYSRNRLKPSD
MPKHEEVLNFAKKLGELIGYKVLSQQIASRVVLLSRLDKPIRVGEGCPGAWKKWSEEWES
EEAEYKLAKENQS
>L9VSC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum tibetense GA33|TrEMBL
MSNSAETGVDTGADADEDGNEDGGPMQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKN
IYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASLKLQKRLL
SGFGGNDEVPREVFEQSMEPRHVAISLDGEPSLYPYLPELIDAFHDRDITTFLVSNGTRP
EVLRECDPTQLYVSVDAPERHTFDEVVGAMEDDAWEKLLETMDILAEKDETRTVLRTTLV
KGENMHHPDWYAGFYQQADPDFIEMKAYMHVGHSRGRLDRSAMPDHEEVVDFTERIGEYM
PEFTEVKDVPASRVALLSKTKDTWVPKLKKGSEFWERDPVTGD
>A0A8C7E9Q0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothoprocta perdicaria|TrEMBL
MDPQNYFYACLMSLWLHRFYIYSSLALGISVWVCIQCFTSLAEAVNSLNLSAEVINMGDY
DPDDSLTEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVSDFRFGKMYLRGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSRHGSIEADFEAWKTKF
LSRLQXLCKGEKKPCSGKCKKGKCKSQGKQSKESSDHGHGTSAEEFFETTSEEESDAEKA
GDTNSVIDVEDLGEIMSHVKKAKVLCINFLAVCVSLCPQSMLRGRGGCYKHTFYGIESHR
CMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEALENHQNMIKQFKGVSGV
KADRLEEAMTAKHCALSLVGEPIMYPEINRFLKLLHQQNISSFLVTNAQFPEEIRNLEPV
TQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLMALSEKQQRTVYRLTLVKAWNVDELK
AYAELVSLGKPDFIEXKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACE
HEHSNCLLIAHKKFKINGEWCTWINYDRFQELAQDYERSGGAKTFTAADYVAKTPHWALF
GSKERGFDPLDIRYQRKNKTKDVSGC
>A0A4Z1FR06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis paeoniae|TrEMBL
MVYDSWMSRPIWSYEIDDIVALWHLYRIPIILTTATILILVRITLRPRALREKLSASPLP
ASPVLPALKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTAASFVESIRGDLSGRANGQRIKFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETIGN
TTGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYSALTKQGYSIVGSHSGVKI
CRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVD
PPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTSM
LHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRCL
EILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGAG
LTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRID
YKKFFECLESGEKFGPEDYVGAETPEWATWGRGGFDPRDERVYRKGKNKVPLPESQGMVM
GEVQDGGEDKVTENSTEDDLAF
>A0A2U4A8U3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tursiops truncatus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLGLPVALINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKDVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIP
DYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYSRFQELVQEYEDTGGSRTFSAKDYMAR
TPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A8C9QP92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
TGVSEEGWSSSDYLLWMWQSRWYGYCAGALLFALWLTVNTAREKKNAVQLANSTQHKIVK
ANGYLVEKEQKIYVSGVKIFFGSQTGTAKGFARNLAEDLHALDLIAEVIDLKDYDPEDSL
SDECTSKAICVFLLATYTDGLPTENAEWFCKWLEEASTDFRYGQTYLKGMRYAVFGLGNS
VYTGHYNTVSKNVDKWLWMLSAARILTRGEGDANVVKSRHGSLEADFGSWKARLLKRLEA
LVRGEKKACSGKCKKGTCKSKGKGKVLEQSEHHSSEEQLMETSSDAESATGEEADHRSVV
DMEDLGNVMNLMRKAKRVPWCEPLGAFTQSLMAHVQLARLYRFSLLPFFFFLSSTGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDPPEIILQEALQNHQNMIKQFRGVPGVRPERFEEGLTAKHCALSLVGEPIMYP
EINAFIRLLHRQRISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDF
WQRFLDSLKALGEKQQRTVYRLTLVKAWNVDELKAYADLISLGQPDFIEVKGVTYCGESS
ASNLTMANVPWHEEVVHFVRQLADLLPDYDIASEHEHSNCLLIAHRKFNVEGQWWTWIDY
ERFQEFAQLYEESGGQRTFSAEDYMARTPDWALFGAKERGFDPADTRFQRKNKTKDISGC
>A0A2H9LDW3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon CG08_land_8_20_14_0_20_34_12|TrEMBL
MFNCLTKEQILRLENQQYRIVGNHSAVKICHWNKTALCGQEYCYKNDFYGIPSNKCLQMT
PSLTCNQRCVHCWRDTSVFSKKFDFKLNNPKEIIEGCIAGRTELLSGFKGNPLVDEKLFY
DSLKPTHAAISLTGEPTLYPKLPELINEFYKQKFKTIFLVTNATNPAMLKKIMKLKKMPT
NVYFSLEAANDKQHRLLNKPVGKSYWKKFNESLELMKKMKKTNTVIRFTAMKNMNMDNPL
EYLPIIEKAKPKFLEIKSYMHVGYSRKRLQEENMPEFDEIKKFAEKIEENSSYKFSKERI
DSRIVLLKRK
>A0A6A5R7X3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Didymella exigua CBS 183.55|TrEMBL
MTPPTSPEQLFAELLSIWHTHRALIIAVGVGLALVVRFTRQSRDAQEEGRGSPAPAAGVQ
EKTVELRPEWLPENTTVVPRALSAEKHAEDDASAVAVFPKAKRGPKTVKGRKTPKKIAKP
VVDYDHTTDKIQPLIFFQSVTGSTERRAKRVAELLTAWTAGCDQAASLLAPQLLDLSEVD
YDDYFISAPKAEANTKHFYLILAPTYNIDTLLDAFIENLSETHNDFRIDTASLSGLLGYS
VFGFGDKEGWPSEEEGFCTQAKQVDKWMARLTGRKRAYPLGMGDVKSDAEDRLTEWRVGV
QEALVEIAEGRGLGEGVLGSGDAVESDEEGVDDGDSGEETRRVDDVEDLGGMADGAAAPI
PVDFTNYKGKPRVNAPAAPKQMVPITSPTHAALTKQGYSIIGSHSGVKICRWTKSALRGR
GSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDVIFDGITA
AHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLRIMHEQRISTFMV
CNAQHPAQLASLIPVTQLYVSIDASNKESLRKVDRPLHRDFWERFCACLDVLRARRFEQR
TVFRLTLVKGFNMEEEVQGYADLVERALPCFVEVKGVTYCGTSAAGSAGLTMQNVPFYEE
VAAFVQLLETELASRGLAYGIAAEHAHSCCILLADGNRFKRDGRWATRIDFERFFALSEG
AVQGSRLQDGKVVGWRPEDYIGPDTPEWALWGNKGFDPRDQRVDRKGRPRTEEEAQASLM
QAALRKAAREL
>A0A3M9ZZA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp. H8|TrEMBL
MSCSGETVEADDDLIQIRPSTSAQLKKAKYGVSGHSTVELCHWTKKSFKHEGDCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYESMEMDPRQVAEPEVILTELMAERKRLIN
GYYGDSRNDMQRLDESLLPSHYAISLSGEPTMYPKLPEMIRYLNSLDTTKSVFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYDSYIRINRPRYDDSWERWNRTLGMLQHLDTRTVL
RITLIRGYNDSKDMIPGFAEMFSRSSPHFVEIKSYMHIGRSTNRLEHSDMLEMEEVREFS
SEITRQSGMFSVMDESSVSRISVLQNNERPINRWISAYADTS
>A0A6C1E0B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces pastorianus|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWQVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A812XAZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium sp. CCMP2456|TrEMBL
MSHLHFAVMGFGSSVYADAGHFCTAAVRADAALAALGGLRVARLLRVTDTKELANQASEW
QLELQSSISAALRGVEIPKARGIEGNAAAEAAVAQTADQEGQGEEDSSDSEDDSSTTVSS
GEAAAKGSTSDVEELAEGCAGDTVKKPEERQMLTTKHRAQLTKEGYKIVGSHSAVKLCRW
TKHQLRGRGGCYKHSFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGTEWKWSMDPPD
QIVAEGIDQHRRMIRECKGIPGVQKERFEEAMTVRHCALSLVGEPIMYPRINELVGELHQ
RKISTFLVTNAQFPEAIRNLDPITQLYVSVDAGTPETLKAVDRPLFSDFWQRYLDSLKAL
KAKKQRTVYRLTLVKGHNMEEAANYAKLVALGTPDFIEIKSVTFCGESKASSLTIQCTPW
HEEVKAFSEAMLSKEGLESQYELACEHQHSCIVLLAHKRYKVDGRWHTWIDYDRFHELVK
SGVEFDATDYWAPTPEWALYGSEEAGFDPNETRVYHNRTKKRAQAGLLSKEQLKMYPDNP
AKQ
>A0A8A3PG79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monilinia vaccinii-corymbosi|TrEMBL
MAYDTWISRPIWSYEINDAVALWHLYRIPIILTTASILMLVRITLRPRVQREKLSASPLP
TSPVLPAVKEKISLPAIDEKKTNGVKTPRRIVGGIKNRKSSQENVQNGFEKIQVLVFFSS
LTGTTEKTANAFTEKLTGNLKTRAQKQEIEYLDPQLLDLSYIDYDDYFINPPKGKAGTGY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGF
CSQARDVDKWLAKLTGRKRAFPLGMGDAKRDAEERLEEWREGVEEVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEILFEEQNVASRKAKMQKKEDSLNDLEDIGGVLNNTETIE
NSAEGQLEELEIDFTTVGLKKGKTKTAPVGAKEMVPKTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LDILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALAASLKRRGLRYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFDCLESEEKFGPEDYVGDETPEWATWGKGGFDPRDERVYRKGKNKVPLPESQGKV
MGELEDNGKEEAEVQDGADVLDF
>A0A7L1UJL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phainopepla nitens|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPGAADKLG
NGCAPPQAQEAHVAGVKIFYGSQTGTAKRFAKALAEAVISLNLPVEVINMRDYDPEDGLV
EEASSRNLCVFLVATYTEGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQAL
CKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGHMKAKPGLGHFQGSRGSHSISGHLCQGLPTLTGKDSFPTSHLSLPSGSY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPI
MYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLF
KDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCG
ESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLLAHSKFQVDGEWRTW
IDYGRFQELVREHERSGGSRTFTAAEYMARTPGWALFGARERGFDPSDVRFQRKNKARDL
SGC
>A0A673C1V0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
MVRPRSVYLLVIGFSFQKQRKNWWIIDFHFKIDKLKFNFKAFFFFSVKTDKPHFKKWIDF
CFLFLITKKKCTSRSVCVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYA
VFGLGNSVYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVK
FLNRLQNLVKGDKKSCSGNCKNGGSCKNKRKDGHGQEEEEDAVTRQNDGSEVMDGRLLSH
GWCLKAKVVLLNGVKKVEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKILQDS
LEKHENMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSHRISSF
LVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFQDSLRALGEKRQR
TVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVA
FVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQVHEDSGGQQ
SFSALDYVAKTPRWALFGAEEQGFDPNDTRFQRRNKTKDISGC
>A0A832V2X1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Naiadarchaeum limnaeum|TrEMBL
MKQLLKLKTEQPKVLEQSVEKVRSILEKQQYDFFGKHGAVKTCHYTKNSLHGKTACYKQQ
FYGIQSHQCIQMTPSVDLCNYNCTFCWRPMEYAPGHEIPWSEADDPKTLVEKSIQAQMKQ
LIGFKGDPTAVPEKVKEMFYPKHVAISLSGEPTLYPRLGEMIAEYHKHGMTTFLVTNGSN
PEAIQKLIDEHHEPTQLYISLSAPNEQLYYKIDRSQVKNGWQRLKKSLEAMCKLKCRTVV
RLTLIRSAMIEPENYTELIKLAMPMFVEVKGYVHVGYSTYRLPESEMPMHNEIVGFAKKI
APLINYEFRAEKEESRVTLLAKPDIKETKIDFLKVKA
>A0A673BZ41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
CLKKFKCGFAKQLSEEVQTLGLTCEVIDMKEYDPDDRLADECTSRSVCVFIVATYTDGQP
TENAEWFCKWLEEASTDFRYGNTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSG
VRIMTRGEGDCNVVKSRNGSVQADFEAWKVKFLNRLQNLVKGDKKSCSGNCKNGGSCKNK
RKDGHGQEEEEDAVTRQNDGSEVMDGRLLSHGWCLKAKLNGVKKVEDEGERREMITPALR
EALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDPPEKILQDSLEKHENMIRQFRGVPGVKPERYEEGLAVKHCA
LSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSL
KKIDRPLFKDFWPRFQDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIE
VKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFK
VDGEWWTWIDYERFQELVQVHEDSGGQQSFSALDYVAKTPRWALFGAEEQGFDPNDTRFQ
RRNKTKDISGC
>D4D6C0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichophyton verrucosum (strain HKI 0517)|TrEMBL
MAAILLQTVTFLAVTEFSSQRKQENQSKGAEQVIQKTIVSDKPAQPENTTLAKSTSLKRE
TKPGPKRLRGLRPLKGDANVTAQVVSAIRPIFFFTSLTGTTEKSARAAFESVKSKLQGAP
QNAQCKVLEPELHDLSYIDFDDYFVTAPKPPTSEPGLSYLYCIILPSYDIDSIINNFLNH
LDETHNDFRIDTSPLSGLTGYCVFGFGDKEGWPTVEEGFCSQAVAVDKWLAKLTGKRRAY
PLGFGDAKTDGDHSLQEWCDGIVSVLHDISENGGGLGEGVPGSGDPIESDEEDAEEDNQR
PHNPSRPRRTKARNIQVADLEDIKFNPKDLLDDEPIDFTTYAPTKISSLFSKEMVPSTSP
TYTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMESTPSLSCSNK
CIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLRGVPGVRAERFAEAMRIRH
CALSLVGEPIFYPHINELLSLLHGEHISSFLVCNAQHPDELAALQRVTQLYVSIDASNRE
SLRKIDRPLHRDFWERLQRCLDILREKRNVHRTVYRLTLVKGFNIDDEVEGYADLVEKGL
PCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNEELERRGLSYGLSAEHAHS
CCVLLASKRFLVNGKWHTRINYERFFELLEREKQTGESFAPEDYMRETEEWALWGNGGFD
PNDQRVHTKGKNKGKIGVPPPSGKVILASTA
>Q5JIY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)|TrEMBL
MAITFVSTPNMPEEIAELFKKQHYAIVGHHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGNP
NVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTLPERLEEMK
REDKLPTQLYVSLTAPDLETYNRVNVPMIPDGWERIKEFLRLMSDAQTRTVIRLTLVKGE
NMHNPEGYAKLIRLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPQGRGLNGRFIKD
>A0A256ZRC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon ex4484_218|TrEMBL
MFNFLLLLLGFRLIGLQVSVKDILISRFKREKYQLVGSHSAVKKCSWLHQSLVREKVCYK
QKFYGIQSHRCLQMTPSAFYCTLRCLFCWRVQPEDLGLKFDEVSFPEPDNPEFIVEESVK
AQRRILSGYKAHKEIDTKKYSEALNPNHAAISLTGEPTLYPLIGDLIAEFHRKGFTTFLV
TNGTNPKALSNLSHEPSQLYISLHAPNEKVFAQTCRPQIANAWKNVLESLSMLKSFSCPT
VVRLTLVKNLNMVKVEDYAKIILNAEPTYVEAKSYMYVGFSRKRLAYENMPTHEEIKVFS
KELSNLTGYKILDEARDSRVVLLSKKDKPLRIGKQ
>A0A1Q1FJ32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorientalis sp. IM1011|TrEMBL
MSDSESGSGGPKQVSNPDYHSENHTAAQTCGWTKNALRGEGKCYKKIFYGIESHRCIQMT
PVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDASIELQTKLLSGFGGNDEVPREVF
EEAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLAECDPTQLYVS
VDAADRATFDKTVKAVEDDAWERLIDTLDVLAGKSETRTVLRTTCIEGLNMHNPEWYASM
FQRADPDFVELKAYMHVGHSRGRLDRDSMPDHERVVEFAEDVMEHMPHNVLKQVPASRVA
LLAEDRNTLVPKLQKDSEFWE
>A0A843CZL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinaceae archaeon|TrEMBL
MVKEIINFGYLPSEISADELMKKQGYAKAGRHAAVKTCTWLKNSMNGQGVCYKSSFYGVT
SHKCLQMTPVLMCNQECIFCWRPTEVPVAPPDEWDSPAVIVEESLKAQRKLVTGFGGSPN
AIRSNYLESLEPSNVAVSLSGEPTFYPYLPELIRLYQEKRMSVFVVTNGTNPDMIRKIRP
TQLYMSLDAADQETYEKVCRPKNPALWENVNESLDVLKAKKEENVRTALRITVVRGYNTG
NEEGFAALIRRAAPDFVEIKSYMHVGFSRLRLDRENMMSTDEIRAFAERIGNFCGYRIAG
ESDASRVVVLTPDGLIRKIGDDDRK
>A0A256XLY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon ex4572_165|TrEMBL
MKKTLIDRLKKQQYGLVGSHSGVKLCHWMKQSLLHKRNCYKQDFYGIQSHRCLQMTPTVN
HCNHNCLFCWRYQGFTEHVIEKPDDPSFILEQSIKEQQRLITGFKGDERCDLKRWEEANK
PNMVACSLSGEPTLYPRLGEFFELCHKKGMTTFLVSNGTNPEVLKEMDPLPDQLYISLIA
PTKETYKKLCVPYITNGWEKIQETLELLPSLDTRTVIRQTLIKDWNFNHKYIENYAKFIK
KAEPLFVEPKGYVFVGSSRQRMNLSNMPSHQEIKEFGLKLSNEIGYEFINEKKDSRVVLL
CKVKKPKRINK
>A0A2D4C3F8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pythium insidiosum|TrEMBL
MGATATAVGALLLTAGALYYVHQQQTQQQQQXQTQKATAAKSHRKKGGNKAKQNGSSKSA
ASAPPSKQEAAELPTVPVRILYGTQTGTAKALAENLEKSLFALHISGFHFQTSVVNLKDY
DQDNLEQESIVIVILSTWTNGVPPQDARVFCSWLNDMALDFRVSKTWLEKVPHAVFGLGN
AEYDEHYGTAAKNVESDLSTLGSPSLCPLGLGDDNVDQVRQFEQWRDTLIASMCEYVSEQ
HASALAAASATNGKKWLSQKEFRRXKKAQQAAQEAANGEAVELNEEDLMNEKVLTGEFSD
DEEDDXPAKKSASSADDGMVDVEDIGKSMKESEAASLSREMVTPMQRKALTKEGYKIIGT
HSAVKLCRWTKHQLRGRGGCYKHTFXGITXYQCMETTPSLACANKCVFCWRHHKNPVGRV
WRWKTDDPEVLVTGAIERHQNMIKELKGLPGLMPHRWEEAFTVRHCALSLVGDPIMYPYI
NEFCRELHARHISSFLVTNAQFPDKIAELEPITQLYVSVDAATKESLQAVDRPLFKDFWE
RFLSCLEQLKLKGQRTVYRMTLVKEYNMAELDNYAELIAIGQPDFIEVKSVTYCGKSDGS
DLTMKNVPWHEEVRSFCAALCERVSGDYGLAAEHAHSNCVLIAKKKFCXDGRWHTWIDYE
KFHALVAKYYEDGTTFTADDYIAETPSWAVYDAPEQGFDPVETRFRRTKDGKVVEFKYEA
TDSGCG
>A0A7S0V940|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Polytomella parva|TrEMBL
MFLTTRTYVVISLLLLCNTAWVCAVGAIYMYLKNLKNKNDDQTLNNKDSKTAVTGRQESA
STPTVVENSMGTCSTNESDECSNEFCCKTQIKTATPGIYVFYGTTRGTCRRLAYQAAERL
TGRSLPVPSSSNTAVAPCATCGKETGSCLESSPVLPFPPGRGLTGDSSFAVGSFLGKPVY
LADLKGFEPEALVSAPQGTVSLFLLSTYEGGVAPDSADFFCRWMLDASQDFRLGKGALNK
LRYSVFGSGHSAYQQNFNAVARAVDRQLWQLGGKRAHPLTHGDEDKGDTEDQLVKWVEGV
IARLIKEEGVAAAEAVVTGSSKSKGSETVQKEKDDKEKTVGSEGAKVNEEGDEEEDQFEF
EEEEEEYDSSYDEEDDEEEDYVSEEDEEEADASASKELPDIEELGGDGLIDAQEKQKTGG
DETSDNANQPLKKGRRAKKPERGDRNKSTKAGAINADASASASPEAPEMLNRMLRASLTK
QGYKLVGSHSGVKLCRWTKSMLRGHGGCYKHAFYGIRSHRCMEATPSLACANKCVFCWRH
HSNPVGRAWKWKMDEAPAIVEGFLEHHRRMIREYSGAPGVRPEFVTEGVNVAHCALSLVG
EPIMYPQINALVQDLHQRRISSFLVTNAQFPDRIAQLSPVTQLYVSVDAADPQSLKAVDR
PLFADFWDRYLACLSGLKEKKQRTVYRLTLVKGWNMEEAEKYAELVKLGEPDFIEIKGVT
YCGGGGASSLTMANVPYHKDVVDFGHAIAESTALNGTYALACEHAHSCCILLARKDRYLV
DGNWYTWIDFDKFHDLANAGAEFESKDYMKQTPDWAVFGSTAAGFDPKQNRVRKTRRHRS
NANSVVGTEDGEDEEVEP
>A0A4Q4Q824|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria arborescens|TrEMBL
MAPRYWHALEPHQRTPREWLAKSSYPNTTPAQRREQRNGTTRAAGTIASWSVNHLITIYV
ADVAAELLFIWHQHRLPILLAALVVATVVRLAIYSRDRREKLSLSPAPSSPVPVEEKPTV
QLKPEWLPEYTTLNSSELNVDNHAEDDTMAVAAAAKVKKGPKMVKGRKTPKKLVAPATFN
HQTDRIQPLVFFQSLSGTTERYAKQFAGVLTEWTRGCDQSKSFLEPQTLDISYIEHDDYF
ISPPKGDANVKYFYIILVPTYNIDTVLDVFVESLQETHNDFRIDTAPLSGLVGYTVFGFG
DREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMADVKSEAEQRLQDWRVGVQDALV
EIAEGRGLGEGVPGSGDPIESDEEDVAEENGQSTRVDDVEDLGSMVNSSAGPIPVDFTTY
KKSPAKSQSVQAPKEMVPTTSPTYAALTKQGYSIIGSHSGVKICRWTKSALRGRGSCYKY
SFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDMIFDGITTAHYKKI
KMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLGIMHSNRISTFLVCNAQHP
AQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQRTVFRLT
LVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMENVPFYEEVAEFVT
ELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRNDRWATRIDFERFFDLYEGKVEGTR
VEDGKVVGWRPEDYVGEETPEWALWGNGGFDPRDARVYRKGKGPKVSEEGGKVTAAALEF
>A0A1D2WCN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. A39|TrEMBL
MSLNDENLKKLEKMGYRFVGNNKHSAAKVCHWTKKSILDEGVCYKQKFYGIESHRCLQIS
PSVPFCHQKCLFCWRDLSVTQTQWKGDFDEPGEIIDGCIDAQRNLLCGFFGNEKANPKKL
QESQDPNNAAISLAGEPMLYPKIDDLIEEFHRRNFTTFLVTNGMTPEKLENLKEEPTQLY
VSLDAPNKETYNKLCNPQVENGWNNLNKSLDLISSFDCRTVLRMTCVKGYNMQNVDEYAD
MIKKTNPDFVEIKAYMFVGYSRKRLTFENMPSNQEIYDFASSVAEKCDLEIKDKSYESRV
VLLK
>A0A256YT74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon ex4484_56|TrEMBL
MISKYLAGKIKKEFERKHYKIFGHSGVQICEWTKKSIRGTDVCYKEKFYGIDCHRCMQFS
PAVAHCNLNCIFCWRPNELMYREIEGKTDEPEEIIENLIELRKKLLSGFGGNESVDKRKF
TESLNPNHFAVSLSGEPTLYPKIIEMIDYLSKKAKSVFLVTNGTKPEILEKLKPRKNFQL
YISINAPNEKLFREICKPSNRKEWSFFNRSLENMSDFKGRKVARLTLIRNYNDNFIDEYV
KLIEKYNPDFIEVKSFISLGYSKKRLGDEHMLKFSEIKKFSENISKKIDYEIINMKQNSR
IVLLKNKSTIFKYFK
>A0A1J1H651|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium relictum|TrEMBL
MIDIYKNFFKIILKHYLIYSKAKINVKLIYGSESCNSYNKAKEFLNELIEFFREIHNFYK
DIKRNIYENENNINENNNLENDILEYFKFYLKNKTGLKKRNNEITWKRDYLKEYEKNIKQ
SKKNFMNYIDCSIETNITIVNFDFISGNEFDFDSFSERLQDYDLNILILFISTYDNGTFP
RNCFKLEEILKDLLNDFRVEKNFLKNVFYSCVGYGNKSYGKEYFCSPINKCDKWLYSLGG
KKLYKTLTLCDEENNEDYIMNWKCNLFKTLFLSIFFYLNHMKLCSFIRYLNMKKYGNLTF
YCSFFCRKYNPIYENGYNKQKCVNSIQSNNLNKNNKELCIDEKLIYYRDNNENKENYFIS
NKKDYSKNHINNFNKSENNNINKQIFNTHKNEENKFEDMINNQNSSIIYKSDKNKSEYDY
NYEESTKIISSETSYDEKDYKKKKNIVTTNSNNYNKVTSLECSSEDELEDLISSVAKDML
TKNQRDKLTKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMEATPSLAC
ANKCVFCWRHHKNPVGVSWKWNKDEAEMIVEEAIKKHKGMIKELKGVYGIIKERFNNAMN
IKHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPDALKNLHKVTQLYLSIDAP
NKEALKNIDRPLFKDYWERYIKCIKLLKNRKERTVFRFTLVKEYNMMVDEISSYAKLIEY
GFPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVHQFALHLINCKSSLANIYEISCEHKHS
CSILIAKKIFKINNKWFTWIDYEKFQSLVKQNKDFNAIDYCAETPEWAIVGSVEKGFSPC
DKRIYTKGKNKNKNLNKNGNEN
>A0A832T9X1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcaceae archaeon|TrEMBL
MDVKPNMPEEITNLFKKQHYALVGHHSSVKLCHWLKESIKNNRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPKPFDDPAFIVEESVKAQRKLLSGYWGVKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEVEVLEKMMKEN
KLPKQLYISLTAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMH
NPEGYAKLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVKNLPGYHIE
DEYPPSRVVLIMRDDLKKADRVIRH
>A0A497S9I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MIPTEVKKVLQHQHYHIVGEHSAVKLCYWTKRSILNRGYCYKQKFYGIQSHRCLQMSPAV
AWCTQRCLFCWRNVEQTLGIKLDRFDDPSEIIENSIMAQRQLLSGYGGIPDRINEKKFDE
AQNPNQVAISLSGEPTIYPRISELIEEFNRRDFTTFLVTNGTLPERLESLDPLPTQLYLS
LDAPDEEIYKRVCNPIIPDGWRKINETLNIFPSLNTRRVIRLTAIKGLNMLKVEKYSKLI
RIAEPDFVEVKAYMFLGGSRRRLTLGNMPSFDDVRRFSEELSEELGYGIKDQKEDSRVVL
LTRDSCNIKIK
>A0A3R7XN35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Peronospora effusa|TrEMBL
MMSPSTSTGVSLLLVAVSVLFYLSTRNRTLPDYAPATLHKVKKSHHKQQKNDKLSEPKPM
TVRILYGTQTGTSKKMAEKLEKTLFALNIAGFHFQTSVVSMKDYDQDNLEQEDIVVAILS
TWTHGKPPKDAQMFCNWITDMTQDFLVSKTWLIDVPHAVFGLGNAEYDEDYGTAAKNLDR
DLAELGSPSLVALGLGDDNVDQFKQFDVWMDNLVAAMCKYSSEKVAAALNKSGSPVKVGK
AGKKEWLSQNEFRRQKRSEKAKAAAANGESIELNEEDLMNEEFLVDEFSDDEEQNQQNTN
DDSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQL
RGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKG
SIERHQGMIKELKGLPGLIPARWEEAFTVRHCALSLVGEAIMYPQINEFCKQLHDRHISS
FLVTNAQFPDKIAALDPITQLYVSVDAGTKESLRAVDRPLFKDFWERFLACLEELKHKGQ
RTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVR
GFCSALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYTRFHELVAKFYKDGA
LFTADDYTAPTPHWALYDSKEQGFDPVETRFRRTKDGKVTEFAYQSTESGLSFCYDYKEG
RKDEVASSTPSSGVAHRNVDKMCLSAMFSHLVELAAPHSTQVEG
>A0A3Q3M9G6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mastacembelus armatus|TrEMBL
MPFLPPASQNEPGPSERAFMSIWHNRLYLYSAAALVFGLWFSLKMARKKVSYALLDIFNG
FAKQLAEEVEALGIPAQVIDMKDYDPDDQLADECSGKSVCVFLVATYTDGQPTESAEWFC
KWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYIGHYNTVGKNVDKWLWMLSGMRIMTRGE
GDCNVVKSRNGSVQADFQAWKAKFLKRLQALAKGEKKRCSGNCKSEGSCKDKRKDGQRKE
QERAALQNNSSEVIDCCEDLIGSSSDEDESGLQDDKKVVDVEDLGSIMNSVMKAKVSLHP
LFGLCGSGSERCLLVESLILLTHCTLMFAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHQCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQNMIR
QFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSHHISSFLVTNAQFPE
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVK
AWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADML
PQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQTFSALDYIA
KTPNWALFGAYEQGFDPADTRFHRRNKTKDISGC
>A0A642UWK6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichomonascus ciferrii|TrEMBL
MELIELWHEYRSLILTLVVVLCVAYYKAVQNVRDMERRQEAVLREKDWYNRRAQETQAKR
EEQEKKKKEAVPLAVDFTTSNKKTRSGPKKFSGQRPKKGMNGRELPSAASRMIIFYSTLT
GTSQRYAERVHKRMCEVMEKEPELQNLDYLEDMDPYFVAPKKELDNTIYLLVVPSYETES
PLDYFIEMLKDTYNDFRIDSRPLARLAGFSVFGLGDSEGWPDEDKYCYQAKRVDKLMGKL
GAKRIFPLGTGCVKTTIDSSVDSYLEHLENTLKDPSPPEEVDIVDSDDEEEAENDDVIDV
EDMGKVIKQTKTKVDDTAKAMVAKDSPTFNSLTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIKSHLCMETTPSLSCSSKCVFCWRHGTNPVGTTWRWQVDAPEDIIKGAMEG
HYKKIKQMKGVPGVVAERFTEAFKIRHCALSLVGEPIFYPHINRFVALLHEQRISSFLVC
NAQHPAELEALDRVTQLYVSIDASDKDSLKKVDRPLHRDFWERLGQCLDILRAKSYQRTV
FRLTLVKDFNTDGIDGYADMVERAQPCFIEVKGVTYCGTSKSNPLTMQNVPFYEEVKKFV
ESLNQTLNSRGMEYGIAAEHAHSCCILIAQKRFNVDGVWHTAINYDRFFDLLESGADFGP
MDYIAPTADWAHYGNGGFNPEDTPHRKGKPINKPTS
>A0A672IHN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarias fasciatus|TrEMBL
MLTLCVFLLLLARPASSRTADSEDVSPPSQPSLLSLWHNRLYLYTAAALILGMWLSLKMV
LKKQNLSSEDVSFISKVERNSHQPHKEIEVHVSGVKIFYGSQTGTAKGFAQQLCQEVKAL
GLPAEVIDMKDYDPDDQLADECVSKTVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRY
GKTYLEGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSAVRIMTRGEGDCNVVKSRSGS
VQADFLSWKVRFLSRLQALVKGEKKSCSGNCKTGGSCKNKKRDEEQQQEEEEEEEEEEEA
SLQNHSSEEDLMESSSDEDESGLQERKPGSVVDVEDLGNIMSSVKKAKSREEVRVKLSKV
NGVKRMEDEGERREMITPALRNALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAHKILEDAVEKHQGMIRQF
RGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHQQHISSFLVTNAQFPEEI
RSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLASLRALGEKRQRTVYRLTLVKAW
NVEEMLAYSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLADMLPQ
YEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYQRFQELVEAHEESGGQRSFSASDYMAKT
PSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A8D0N731|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMGRVKKEKREKAQQEGETGVLRSAVKNEASEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFS
>A3CXN7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)|TrEMBL
MRSEACKALKKQGYQFITPTSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LKCNQQCLFCWRSFEHEVVEEEECPPDVIVENLRRVQKRALSGYKVSPYVAPERFAEALD
PTMVAISLSGEPTCYSRLPELVDALNADGYTTFLVSNGTRPDVLARCRPYQTYVSLDAPD
RETYLALCRPREDYWDRIHESLAGLRERRSAIRTTVVRGYNDFSPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRTQMPEHSEVRAFAEKIAEYCDYCIMDESPVSRVVCLERDV
>A0A8D0ZRQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQVSQSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRW
KMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRF
VKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFL
DSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLT
MANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQE
LIQEYEDSGGSKTFSAKDYMARTPQWALFGASERGFDPKDTRYQRKNKAKDISGC
>A0A8B7T3Y6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hipposideros armiger|TrEMBL
MDPSLDTWDFSPLIALWINRFYIYLGFAFGITLWICFQIVIRNQSFIFKDQNSQDKSVPK
ATRDLMTNGSTSFQKKEVFVSGVKIFYGSQTGTAKVTSKNVCAFLIATYTDGRPTESAEW
FCKWLEEASNDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAQRVTTR
GEGDCDVVRSKHGSIEADFRAWKAKFIFQLQVLLKGEKKPCNCNCKKGKCESRQPGSEEV
EPGSHAQDGLQQGDTEEGPFESASADESGPEDQPSVPSVVDVEDLGTIVSRVRKEKRAKA
QQEDKAGLFGNAVTNEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIEN
HQNMIKQFKGVPGVREQRFAEGMMVKHCALSLVGEPIMYPEINRFLKLLHKCKISSFLVT
NAQFPVEIRNLTPVTQLYVSVDASTEGSLKKIDRPLFKDFWQRFRDSLKALAAKQQRTVY
RLTLVKAWNVDELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVH
ELVGLIPDYEIACEHEHSNCLLIAHKKFKIDREWWTWIDYNRFQELIQEYEDSSGSKTFS
ARDYIAKTPHWALFGANERGFDPKDIRYQRKNKTKDISGC
>A0A8B7T2F9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hipposideros armiger|TrEMBL
MDKQVLHIFGLCLWHYPLDLFPDCHQEPATRDLMTNGSTSFQKKEVFVSGVKIFYGSQTG
TAKGFAAALAEAVSSIDLPVAVINLKEYDPDDHLLEEVTSKNVCAFLIATYTDGRPTESA
EWFCKWLEEASNDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAQRVT
TRGEGDCDVVRSKHGSIEADFRAWKAKFIFQLQVLLKGEKKPCNCNCKKGKCESRQPGSE
EVEPGSHAQDGLQQGDTEEGPFESASADESGPEDQPSVPSVVDVEDLGTIVSRVRKEKRA
KAQQEDKAGLFGNAVTNEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAI
ENHQNMIKQFKGVPGVREQRFAEGMMVKHCALSLVGEPIMYPEINRFLKLLHKCKISSFL
VTNAQFPVEIRNLTPVTQLYVSVDASTEGSLKKIDRPLFKDFWQRFRDSLKALAAKQQRT
VYRLTLVKAWNVDELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRF
VHELVGLIPDYEIACEHEHSNCLLIAHKKFKIDREWWTWIDYNRFQELIQEYEDSSGSKT
FSARDYIAKTPHWALFGANERGFDPKDIRYQRKNKTKDISGC
>A0A497ETN7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MLDNDMLNDEIYSALRRQGYHIVGRHSAVKTCHWLKKSLTKGEYCYKQQFYGIQSHRCLQ
MTPSVVYCTNKCIYCWRLVPEAIGVSWNEIELLDVDDPEVIIDGAIAEQRRLLTGFYGNP
QVDRKKLEEAMNPKHAAISLSGEPTLYPKIGELIEAFHARGMTTFLVTNGTRPDVLSKIT
EPTQLYISVSAPNEDKYRNICRPLIRDNWVKLNKSLELMKSFSCPTVIRLTLVKGLNMEG
GDLQGYSELILKAEPTYVELKAYMHLGYSTARLKFENMPSHQEVRDFAERLASMIGYNLL
DENSKSRVVLLSRLTKPIKVSRE
>A0A7J2NQV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLQSLVPEEIVRMLQRQKYHLVGSHSAVKRCRWLYNSIVQDRSCYKQKFYGIKSHQCLQM
TPSVFHCTLRCVFCWRAQSGDYDLRWDETRLPEWDDPETIIEGSIREQKRILSGYKANSE
ADQKKLLEAFTPKHAAISLAGEPTLYPHLGGLIKGFHRRGFTTFLVSNGTVPETLSSLSE
EPTQLYISVSAFDKKTFSQVCRPHIPDAWEKLNETLELLPSFRCPTVVRLTLARHVNLKH
PEVYAQLIRKANPTYVEPKAYMHVGFSRLRLDGSNMPSHREIREFAAQLANEMSYNTLDE
SEDSRVVLLSRLEKPIKLA
>A0A7J2I585|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPEELLRTFRKQGYQLAGRHSAVKTCHWTRQSLLTSERRVCYKQKFYGIRSLRCMQMTPT
LGRCTQNCLFCWRAGALDLGLAWNQTLFPPEEADEPEVVVEECLKAHWRALIGFKGNPKV
DLELLNLALNPVHVAISLEGEVTLYPMIGELIEEFFRRGFKTVFLVTNGTLPEVLENLSR
EPTQLYVSLCAPDEETYVRVCRPAVKDGWERVNRTLELLESFSCPTVVRHTLVRGLNMRN
VEGYAKLDLKANPTYIEPKAAMAVGFFLNRLPREAMPTHGDVVEFSKRLSELTGYDIIDE
SRDSRVTLLSRLEKPIKWGCFNAPSHP
>A0A497KPE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MFVNFPITLIVFCFSLGYWRSGTPKMQQILEQLITRLKREKYQLVGKHSAVKKCSWLHQS
LTKGKVCYKQKFYGIQSHRCLQMTPSVFYCTLRCLFCWRVQPEDLNINFKVDETAFPTPD
DPRFIVEESILAQRRILSGYKAHVEIERKKYEEALNPNHAAISLTGEPTLYPLIGDLINE
FHRKGMTTFLVTNGTNPKVLSQLNHEPTQLYISLHAPNKEIFAKTCRPQIPHAWENVKES
LELLKSFRCPTVVRLTLVKDLNMTKIEDYAKLIQKTESTYVETKSYMYVGFSRKRLTYEN
MPTHDEIKVFAEKLSELTGYKIIDEARDSRVVLLSRLDKPIKVGKTS
>A0A2V1CD79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cadophora sp. DSE1049|TrEMBL
MITTIMAHDTWTLRPLLPFEIADIVAVWHIYRIPIILTTVIALIIVRTFLHLRFPRHKIT
DTPLISPALPALKEKPAPAEKKTVAENVPRRIVGGLKKKKSSQEDIKSNKQNIKVLVFFS
SLTGTTEKTAKVFTEALAQSTKKLGETTSTTFLEPEILDLSYIDYDEYFINPPKSDSGAQ
YFYLLLLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEG
FCSQARDVDKWMAKLTGRKRAFPLGMGDTKKDAADRLAEWKDGIEDVLNHIATTGSLGEG
VVGSGDAVESDVEDVDDEDEVLFDEQKVAQRKTKVQKKEALNDLEDIGRSLNKTEAPEAD
LEELELDFTTYSKKPVSKAAAVIKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEMIFD
GVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHIS
SFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRERR
FEQRTVFRLTLVKGFNIEDEAEGYAALVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVP
FYEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILLASERFKVQGKWHTRIDYQKFFEC
LESGEDFRPEDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTEKQGEMMEI
>C5E2D4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)|TrEMBL
MELSTKLTDHLVVCAVVAVYLISGGRLSIGISVAVLYALAIHDSGRKVEVSEAGIIQAKS
GVAGKPEKKTCCGGKGGSSCCSSGSGGKKGGCCGGSCASKKRAEEKPASTGPVFESSASE
PIAIDFTHAFKPARSSKPKSGAKKMPRFISRTAGSAKKDTGFFKKALTVSNEKLSNSQIY
VFYSSLQGAAERSAKTVLETLSGMPELKYEPKLLNLDELSDFDDYFVNVPCSYALYILVL
PSYDSDSPLDFFLQSLQENASDFRIDKYVLRKLVGYAVLGIGDSESWPEKFCYQARQADL
LLAKQGGRRVFPVGEICMKFGGDPKVSEWSKLLAETLCDDEPILYEYDETLDDEEPQDPE
DELTKEPLIDLEDVGKSSELQDVSSVKKMIVKDSPTFKNLTKQGYTVVGSHSGVKICRWT
KNDLRGRGSCYKHSLFNIVSSRCMELTPSLACSSKCIFCWRHGTNPVSKTWRWEVDDPEY
ILENALQGHYAKIKQMRGVPGVIAERFAKAFKVRHCALSLVGEPIMYPFISKFVSLLHQK
EISSFLVCNAQHPEPLRDLGKVTQLYVSIDAPTKNELKKVDRPLYRDFWERLMECLDILR
TTQSHQRTVFRMTLVKGFNMADVSAYADLVQRGLPCFIEVKGATFCGTSDGNGNPLTMQN
IPFYEECAKFVKSLAAELQRRGLGYDVAAEHAHSNCILIASTKFKINNEWYTHIDFDRFF
ELLNSGKDFNHMEYLQKTPEWALFGNGGFAPGNTRFYKKKRGQEAQAKEEQGLQENVSTQ
PINA
>A0A0H4TMB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured euryarchaeote Rifle_16ft_4_minimus_23719|TrEMBL
MDPERKEVLERQGYRIVGEHSGVKLCHWTKASLSKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLGCMFCWRTQEWGSDGLLEADDPSSIVDGSLEAQRALLSGYKGHPGVTRERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDDFKRRGMSTFLVTNGTTPAVLRRMREEGRLPTQLYVT
VAAPNEDVYRRLMAPKSDHEWAKLLETLALLPEIPTRTVIRHTLVEGWNLGWEDEYAALD
RVAKPMSIECKGYSFVGESRLRLREENMPSHASIRTFARALADRLGYAVAAEREDSRVVL
LTPDGELHPVSS
>A0A6A6XUJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Melanomma pulvis-pyrius CBS 109.77|TrEMBL
MASPGLVGQLPTELLFIWHTHRIPILFTAVSVLAILRLALYYRRTREKISTSPLPLSPIE
KTVVELRPEWLPENTTLDPSILNLDNHAEESTIVAAPLEKARKGPKTVKGKKMRSKVSKT
APTFDHKIDQVQPLIFFQSLSGATERYATEFAKIFSSWASSSSSSLLSPQILDLSYIEFD
DYFISPPKSDSNVKYFYLLLLPTYNIDTVLSTFLENLQETHNDFRIDTAPLSALLGYSVF
GFGDKEDWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGNVKGDASARLEEWRVGVQE
AIVEITEGRGLGEGVPGSGDPAESDEEDIDVVEDSDVEVISRKLVRPKKTARVDDVEDLG
SMVNSSNSDSLLPIDFTTYKSKPASTQAPKEMVPITSPTHASLTKQGYTIIGSHSGVKIC
RWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDA
PDLIFDGITQAHYKKIKMLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLNIM
HRNRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCTCLD
IIRNRRFEQRTVFRLTLVKGFNMAEEVKGYADLVERALPGFVEVKGVTYCGTSAAGTAGL
TMQNVPFYEEVAEFVTELEKELNARGLMYGIGAEHAHSCCILLADSTRFKRDGRWATRID
FERFFDLHEGKVEGTRLEKGEDGTAKVVGWRPEDYIGQDTPEWALWGNKGFDPRDVRVYR
KGKGPKADAENAAEAEAKKGNFKLVEI
>A0A8I3MFS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus familiaris|TrEMBL
MDPFSDTWDFSSPVISLWINRFYIYLGFAFGISLWICFQIVIRKQLFILKGKKSQEKSVP
KATGDLMTNGCISLQNKEVFVSGVKIFYGSQTGTAKVTSKNVCAFVVATYTDGQPTESAV
WFCKWLEEASSDFRFGKTYLKGMRYAVFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVA
RGEGDCDVVKSKHGSIEADFRVWKTKFLARLQALQKGEKKPCDGNCKRGQCESSVEEEPS
ESTSEEESGTEDHQNLNSVVDVEDLGKIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSER
RTMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFE
EAMMVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVS
VDASTKDSLKKIDRPLFKDFWQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELV
SLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNC
LLIAHKRFKIGREWWTWIDYNRFQELVQGYEDSGGSATFSAEDYMAKTPHWALFGASERG
FDPKDTRYQRKNKSKDISGC
>A0A327HPX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKSKLQKQRYHIVGDHGGVKICHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELSDQDPLEMLYESVRAQRRLLSGFGGNPKVPREKFLDAQNP
KHVAISLNGEPTLYKRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGKNMNQEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTSENMPFHDDILEFSNALAPLTDRKLLDDSPPSRVALV
GKEIVPIPLPEATMFFPEDLGVADPVKHLKVIQ
>A0A327HHP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPLEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRSLAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMYFPDDLGIAESVKHLKIVQ
>G3QGJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gorilla gorilla gorilla|TrEMBL
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIE
ADFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KGEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERRLLQTHILWNESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAECFEEGMTVKHCALSL
VGEPVMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQRFLDSLKALAVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDY
EIACEHEHSNCLLVAHRK
>A0A2E5WWY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPIELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A2D8SX79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MLESPPDRSATVVNDSEVRIMDPKLKAKLQKQRYHIVGEHGGVKTCHWTXESLLRGRQCY
KGRXYGIESHGCMQMSPVVDQCNLACTYCWREPXMDTLELTXXDPLDXLYESVXAQRRLL
SGFGGNDKVPREKWLDAQNPKHVAISLNGEPTLYTRLSEYMELCHKHGMTTMXVTNGTLP
KVIENLDTLPTQLYVSVDAPNKTVFDDICKPKWNQGAWEKFEQTIDLMPSLDTRTVCRHT
LIKGKNMSHQHIXEFAELDNRADPDYIEAKGYVHVGHSQENLAASNMPSHEDIXAFSHEI
APLTNRQVLDESRPSRVALIGTEIIPIQVPEAQMYFPEDLGIAPPVKHLPVI
>M2SR97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cochliobolus sativus (strain ND90Pr / ATCC 201652)|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLLILLSALVVATIARLIIYSRDRREKLPTSPVPQSPIE
KQKVELKPEWLPEYTTILSSPDLNVDNHAEDDTGAVAAATKAKKGPKMVKGRKIPKKSVA
PTLTFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTGCDQASSFLEPQIHDISYI
EHDDYFVTPPKADANVKYFYTILIPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGDAEKRLEEWRVG
VQDALVELAEGRGLGEGVPGSGDPAESDEEDVDDAEDGNGQSSRVDDVEDLGSMVNSSSS
PIPIDFTSYKKSAPKPKSATAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPEMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINQLLDIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELTSRGLQYGIGAEHAHSCCVLLADRTRFMRDGRWATRIDFERFFDL
NEGKVQGTRVEDGKVVGWRPEDYIGDETPEWALWGNGGFDPRDARVYRKGKGPKAEVEKS
EGLEVQTKKAALEF
>A0A6P7V3I6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ixodes scapularis|TrEMBL
MIGIVLCIVFAAPANGREVVSEHWTSGWLPSSFATTLCGGVVMVLFFVVVREKFKFSKIQ
SDSHVKKKKKNPDGRSIKILYGTQTGNAKILSEKLLAELEALNHDVEIVNLKHIEPEECL
LGQVKSKGLCIFIVSTYVDGGPPDEAVWFYDWLKDTYADFRVHKYFLQGLDYTIYGLGDS
AFNDNYNKVARDIDFWLSKLHARRVVPLCLNDESVDEGKYGTGKFGAWKSQLLAQLRLGA
KGATQFDAPEEKPAAYETSSDEEGGGDLIDLEDLGTVRIASKNKAKAEGAAGQPKDMLTP
PVRESLTKQGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIDSHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWKWNMDPPEMILDAALESHYKMIKEFKGVPGVLRERLAEGLAVR
HCALSLVGEPIMYPEIGRLVRLLHARRVSTFLVTNAQFPEALEALGPVTQLYVSVDASSR
EALKRIDRPLFPDFWQRFQDSLIALARKGQRTVYRLTLVKEWNMEEMQGYANLVELGKPD
FIEVKGVTFCGESKGSSLTMGNIPWHEEVLSFVERLAALLPDYSIASEHEHSNCVLLAHH
KFRVDGVWHTWIDYERFHELVQRHYESGEPFGSLDYAAPLPPWATFGARERGFDPSDTRM
LRRSRKDVGGC
>A0A7K4NQ58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSGEVVEKEPELIQIAPSIVKQLKKAKYGVSDHSTVELCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYESMEMKPENVAEPEEIMTNLMAERKKLIM
GHYGDPNQDKKKLDESLHPQHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYKSFLKINRPRYDDSWERWNRTLKMLSTLGTRTVL
RITLIRGYNDNEEMIPVFASLLQKSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRSFA
NKLAQENSDFTVMDESGISRIVILQNKKRFVDRFIPACC
>A0A834B2T3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MAAPSSVISGPSLDSWDFSPLISLWINRFYVYLGFAFAISLWICFQIAIRKQLFIFKDKN
SQKKSVPKATRDLMTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPV
AIINLKDYDPDDNLVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEASSDFRFGKTY
LKGMKYAVFGLGNSVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEAD
FRAWKTKFVFQLQVLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEEE
EPCESSSGEESGTEDHQSLTSIVDVEDLGKIMSHVKKEKREKEQQEEKTGLFRNTVKKEA
GERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGVKEE
RFKEGMTVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLTPVTQL
YVSVDASTRDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYA
ELVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVALIPDYEIACEHEH
SNCLLIAHKKFKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPWALFGAN
ERGFDPKDRRYQRKNKSKDISGC
>A0A6A6UIS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microthyrium microscopicum|TrEMBL
MAENSSSLSSVRWETLPAEVLQIWHQYRTPIIVSLTVILVALRTLHILRNRNKQELDRKL
PLLSSAGPKSVDTNRTSSERVGENGNTEKPQSGPKRIVGKKLARASMISAGFSPATDKIQ
PLVFFSSLGGMTEALATKLSQELDVWSETLEDPSTILKSSLLDLSYIEQDDYFVSPPKGE
PNTSYFYLLLVPTYNIDTTLNNFLENLKETHHDFRIDTAPLARLLGFSVFGFGDKEGWPT
EDEGFCSQAAEVDKWMAKLTARKRAFPLGMGDIKSDWKTRLAEWQDGLQNVLLEIQKGNG
LGEGVPGSGDAEESDVEEEEEELDSKKVPKKKAGKSTLDDVEDLGGSYRGSGESTGPLAI
DFTTYGSKAKTVENTSREMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSC
YKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPDLIFNGVKEGHY
KKIKMLKGVPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLAMLHKERISSFLVCNA
QHPDELAALDHVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILREKRFQQRTVF
RLTLVKGFNIEDEAEGYAELVARGLPCFIEVKGVTFCGTSTSAGAGLTMQNVPFYEEVCE
FVHALVAALERRGLEYGIAAEHAHSCCVLLGSTRFKIEGKWHTLIGYEKFFECLESGEEF
GPEDYVGEPTPEWALWGNGGFDPRDERFYRKGKKAVTCDG
>A0A226MGY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callipepla squamata|TrEMBL
MDTWNFFYACLVSLWLHRFYIYSVTAFGISLWFTVQFVTTKAKRKDENSNGNLVSSEVVE
DKLVNGYAAVRPQEVCVAGVKIFYGSQTGTAKRFAKDLAEAVTCLNLPVEVISMGDYDPD
DYLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETADDFRFGKTYLKGLRYAVFGL
GNSAYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFEAWKTKFLSC
LQALCRGEKKPCSGKCKKGKCKSQGKPRKESTNDERGAAVFEDAEGEELFETTSEEEADA
ENTGGPDAVVDVEDLGKIMSHMRKAKEMEDLMDDARERELEEGDAGISLLGDTSGRKEAG
ERREMITAALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEA
TPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEALENHQNMIKEFRGVTGVRAER
FEEAMTAKHCALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLY
VSVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEK
>A0A0D9QP52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium fragile|TrEMBL
MVKGGEANKRRNFFQTIFEQHAVRKRKKANINLRIVYGSEGSNSYKKAKVFLNDLIQFFK
DIENICNEINRIITEEGGSHHMFNARTNEVGHADDRLVKYFKEYSKLLQRRNEETARSGK
KDSFLAGGVNGTHEGLQQFQEKEKKCSDKFVNYLDCCISTNVCTVNFDFVNGNEFNDYTF
FERTSEYDLNLMLVFVSTASNGSFPRNCYKFEQLLEDLFNDFRVEKDFLKNIFYTCIGFG
NKHYGSTHFCAPVKKCDKYLSYLGAQKLFKTLKLCDEEDNEELFLVWKCSLFKTISLSLL
FYCINFPQLGYFMPYADRKIYNSLKHYCFFFCSKADNRKGRCEGASIEVPQEGGQHSHVA
DQKGESTQASDPSMGNPPKGDPCTNASCSTCGEGTQHGCTPPNGDQWEQVPTAKNSEDEM
EEKDALNYGIKKREDVKKSISLCSSGDEMEDLIPDKPKDMLTSNQRDKLTKEGYKIIGSH
SAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTQW
KWNKDDAEMIVEEALKKHKGMIKELKGAHGVIKERFDEAVNVRHCALSLVGEPIMYPDIN
KMIDELHRKNVSTFLVTNAQFPNELQKLHKVTQLYLSIDAPNEEALKNIDRPLFKDFWDR
YIRCIKILKKRKERTVFRFTLVKEYNMMSEEILSYSKLVEYGYPDFIEIKAVTYCGSSDG
YQLTMKNIPWHEEVYQFASSLINSNGYLSDSYEIACEHRHSCSILIAKKEFKINDKWHTW
IDYEMFQRLVRQNKDFTAADYCVETPSWAVIGAEERGFNPCDERVYTKGKKKNKQPAAEN
TSQ
>A0A4S4F3B5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Camellia sinensis var. sinensis|TrEMBL
MSSPSSSSSSSAAAHLTLLALLSATTFYCFYKSRRLKKLSSSQTLHPLNLSPPPPPKPKL
FFISHTGTSKTLAHRLFDLLTSNDLAFDLVDPNHYEPEDLHRETLVLIVASTWEHGKPPP
SGGFLANWLAESAEDFRVGSLLLSKCRFAVFGVGSKAYGETFNAVAREFSKRMRALGAAE
LLAVGEGDVDGGELDEVFDGWTKKLIEVLKGGFLENGVRGWNESDSEMISSDGDDDDGEE
NGEESGIVDLEDIAGKAPSRKSKTVIQSNGKLNGEKEMVTPVIRASLEKQYSVFYDMDMH
DVLVCLMGFNFKLQLSDLRSINCSVFSIARRCMETTPSLACANKCVFCWRHHTNPVGKSW
QWKMDDPLDIVNSAIDLHTKMIRQMKGVPGVKLERLTEGLSPRHCALSLVGEPIMYPEIN
SLVDELHRRRISTFLVTNAQFPDKIRMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWER
FVDSLKALREKQQRTVYRLTLVKGWNTEDIDAYSSLFAIGNPDFVEIKGVTYCGSSATSK
LTMENVPWHSDVKAFSEALAQKSEGNYEVACEHAHSCCILLAKVDKFKVNGQWFTWIDYE
KFHDLVASGKPFDSNDYMAASPSWAVYGAEEGGFDPGQSRYRKERHHKSSH
>G1PN63|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myotis lucifugus|TrEMBL
LDPSSDTWDFSPLISLWINRYYIYLGFAFGIGLWICFQIVIRKQDKNSQEKSIPKAAQDL
MTNGYSSLHKKEVFVSGVKIFYGSQTGTAKEFATILAEAVTSLYLPVAVINLKEYDPDDN
LVEEVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASNDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGSIEADFRAWKTKFISQLQ
VLCKGEKKSCDGSCKKGKCESNQRSSEEMELGSHTQDGLHQRDPEEEEPFESSSEEESGT
EDHQSLTSVVDVEDLGNIMNHVKKEKNEQESSSSQKGSFQCLTHTETKGKKLLIASRLNN
KVLKSGYPIQLILSYSSCAQHAWSQSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEVILKEAIENHQNMIKQFKGVPGVKEERFKEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRLPRNLKPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGHP
DFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVDLIPDYEIACEHEHSNCLLIAH
KKFKIDREWWTWIDYNRFQELIQEYEDSGGSKTFSAEDYMAKTPHWALFGANERGFDPKD
TRFQRKNKSKDISGC
>A0A7L3EJH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chaetops frenatus|TrEMBL
LDVSMDTWSYFHACLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPETADKLG
NGCALPQAQEVYVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPEDGLA
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEASSDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKVKFLTRLQAL
CKGEKKPCSGKCKKGKCKSSEKQSKESLDHEHGTSEHENTEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGHMKKAKHGVHGVSHSGYHLVYFVCQFLQAKLNCLIIFALFSGYKLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEW
RWKLDQPEVILQEAMEQHQNMIRQFKGVSGVRAARLEEALAVKHCALSLVGEPIMYPHIN
SFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQR
FLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASS
LTMANVPWHGEVVSFARELARLLPEYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDFGRF
QELVREHERSGGCRTFTAAEYTARTPPWALFGAREQGFDPLDVRFQRRNKARDFSGC
>A0A1D2X3T1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. WGK6|TrEMBL
MLISETKQKDLEKKGYRFAGEKVHAANKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PSIPYCQHKCLFCWRDTEITKTSWDTDDYDDPKTIIEDCIKNQANLLCGFFGNEKANPKK
LEECVKPNNAALSLAGEPLLYPEINQLIEEFHKQDFTTFLVSNGESPEKLKALQEHEPTQ
LYLSLDAPNKEVYKKVCKPQVNNGWEKLQESIDLLSTLDTRKVLRITSVKDLNMIHTEEY
AKIIENSDIDYVEIKAYMFVGDSRNRLEWENMPKTIDIQQFAQDIADKTSFDIIDEVEKS
RVLLLGDKKPGKYNN
>A0A7K5XR51|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dromas ardeola|TrEMBL
LDVSMDTWDFSYTCLVSLWLHRFYIYCVVAFGISIWIIIQFTTTKTKKKVTEAISIASEG
IEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFATGLAEAIISLNLPVEVISMGDYD
PDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYAVF
GLGNSVYVDHYNTVGRSIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
SRLQALCRGEKKPCSGKCKKGRCKSSRKQSKESSDHEHGTSEHENTEAEELFETSSEEEA
DAEEAGGTNAVVDVEDLGNIMSHMKKAKVLLLGLSVRARDPHVGGHSDPAHLGWVPVTIS
TIKTTTSYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILQEAIENHRNMIKQFKGVSGVKADRFEEAMTAKHCA
LSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFVE
VKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLIAHKKVR
L
>A0A6J3GRR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapajus apella|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGFVSLHNKDIFVSGVKIFYGSQTGTAKGFATVLAETVVSLDLPVAIINLKEYDPDD
CLIEEVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSVYASHFNKVGKNVDKWLWMLGARRVVSRGEGDCDVVKSKHGSIEADFRAWKTMFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSEEQDELHHRDTEEEEPCEGSSEEEF
GGEDQQSINSIVDVEDLGKIMDHMKKQKREKEQQEEKTSLFGNTGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVKHC
ALSLVGEPIMYPEINSFLKLLHQRQISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KVGSEWWTWIDYNRFQELVQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A6B2C301|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcales archaeon|TrEMBL
MTIRITQVDYSNLQKLMRKQGYHFVNEHTVVKPCLWTRKAILQRRFCYKCLFYGIESHRC
IQMSPAAYWCWNDCIHCWRVRPPDVGIPFELSMPKYQEDIDALVDNIIETQRKLLSGYWG
NPKADKELVKEAFEPKHVAISLTGEPTLYENLPSLIKAFHRKGLTTFLVTRGVRPDVLER
LYSEEPPSQLYISIEAYNKEKYEQINKPLVPRAWELTMRSLEIMSSFPSPTVLRITAIKG
INMDSNAVEGFRKIIEIARPKYIEVKAYMHVGSSTQRLTKSNMPSFSDIWAFSEELSKAT
GIPIRSYAKDSRVVLLSELERPVRHGKGCPNYLWLSKS
>A0A8H4Z5D8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium austroamericanum|TrEMBL
MDWANHSSPSRLDSFVDELFDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKSKVAVEEVKVEYVEIKEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPFVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKGHGDADLFYLFLVPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLREKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A7K5R7R2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunella himalayana|TrEMBL
LDVSMDMWGYFYTCLVSIWLHRFYIYSAIAFGISLWIVIHFTTTRTKRKVTEPRTADKLG
NGCAPRQAQRVHVAGVKIFYGSQTGTAKRFAKALAEDVSSLNLPVEVINMGDYDPEDGLV
EETRSRNICVFLVATYTEGQPPESAAWFCKWLEEAASDFRVEKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKSKFLTRLQAL
CRGEKPPCSGKCKKGKCKSSGKQSKESSDHERGTSEQDNTEGEELFETSSEEEAGGMDSV
IDVEDLGNIMDHMKKAKVLLLEGAWNVHGVSHSGYHLVYFVCQFLQAKLNCSVICALFSG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPHINSFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYC
GESSASSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHSKVSLPG
>A0A1B2JEY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Komagataella pastoris|TrEMBL
MALINHLILVSALVCYLATGGRISIACLAVVLYCLLQGSSTLPSTSRSASSTCGHSKSPE
KTFSSPVKDESSYEILPNGAVKLTRSSNGNKESPMFKRKDDTKQRKKRVPKIFKANKPHS
PKFKEGLTATSHSLLDSNFIIFYSSLTGSSAKAATTLHGKLSEIATNKPQLLNMDEDVND
LEDYFVNTPDLKNLVYILVLPSYDTDSPLDYFLESLEETSNDFRIDKFPLKKLAGFTVLG
LGDSESWAEKFCYQAKLVDKWLSKLGARRIFPLGTICIKTGGEPKINEWIDIFDETLKDD
DPMLTENEPEVSIRDLNNEYDDDEADVSDDTLVDVEDMGRMIAKTKEENEISQVSEKKEM
VAKDSPTFKSLTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKFAFYGIRSHLCMETTPS
LSCSNKCVFCWRHGSNPVGTTWRWQVDQPQDILNGALEGHYKKIKQMRGVPGIVSDRFNE
AFTVRHCALSLVGEPIFYPYINEFLQMLHAKHISSFLVCNAQHPDQLRTLNKVTQLYVSI
DASSKDELKRIDRPLFRNYWERLHECLNIIRTVQSHQRTVFRLTLVKGFNMGDFKGYADM
VESALPSLIEIKGATFCGSSSGNGNPLTMQNIPFYEECQNFVRSLNDELNSRGLEYGIAA
EHAHSCCILIASKRYYINSQWYTHIDYKKFFRLLESGEKFTHMDYLAPTPEWAYWGSSEG
GFNPEDVKYNRKEEKEKKRLAREQSKQLEA
>A0A2B4SDC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stylophora pistillata|TrEMBL
MAIQEACSLICCFCRAFTLLLVSMSVQVSAAHSPIDPSVLRKPDWQDRLVTWWMSVRGPI
ATLILGGLGLSWLIIKITGKEKHRAEYLRWKAKQEKENKKGVLKSPTDERETIISKDLKI
FFGTQTGKAQSLAELLQSEAQESGLRTELVDLKNYEPEDNLSEETGTCIFIVSTYVDGKP
PESVQWFYKWLEEAANDFRVQKSLLQGLNYAVFGLGNSLYEENFNLVGKRVDKWLELLCA
KRVFPFGMGDENVANSKHGGTEEDFKFWRTDFLSFIKGTSGKSTRNVCQCSSGSNSQSDE
TCYQGDEGPQENEGEDDEVLYESTSEESAAEDEEENNSGLLDMEDLGPMMNKMKKDKEEK
EASSLKGSKKVVGSKKKVKTEPKEMITPALEKALTKQGYRLIGSHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWKMDDPDTIVNGAM
ENHRNMIKQFRGVPGVKPERFEEGMKIRHCALSLVGEPIMYPRINELVRILHGHDISSFL
VTNAQFPDAIRNLIPVTQLYVSVDASTKESLKKIDRPLFRDFWPRFLDSLKALSEKGQRT
VYRLTLVKSWNNEELKNYADLVSIGKPDFIEVKGVTYCGESKASTLTMQNVPWHEEVIGF
VQKLTDLLPDYEIACEHEHSNCLLICHKKFKKEDGWCTWIDYTTFHRLMQRYEESNGREN
FTALDYMAKTPEWALMGHDQRGFDPQETRWHRKKKKDISGC
>A0A6A6EBF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zopfia rhizophila CBS 207.26|TrEMBL
MDTPDTLRQLPAELLLIWHSHRISILLSTASLVTIIRFTIYLRGKREKLSVSPIPGSPTE
KTVIELKPEWLPENTTLDPSALNIDNHAEGSTIAIPPAGKAKKLPRTVKGQRLPSKTLKP
ASIFNPTTDSIQPLIFFQSLSGTTERFASKYVENLSSWISTSQPISSLLEPQVHDLSYIE
YDDYFISPPKGESHTRYFYLILLPTYNIDTVLSTFLENLQETHNDFRIDTAPLTGLLGYA
VFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGLGDVKMDAEQRLEEWRFGV
QEALVEIREGRGLGEGVPGSGDPAESDEDDIDIAQDSGSEDVLIQSSLVNTSISDAPIAM
DFTTYKSTTYKSTTSKSITQPQEMVPVTSPTHSALTKQGYTIIGSHSGVKICRWTKSALR
GRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDPPDVIFNGI
TEAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELVNIMHRNRISTF
LVCNAQHPAQLAVLVPVTQLYVSIDASNKQSLRKIDRPLHRDFWERFCACLDILRNRRFE
QRTVFRLTLVKGFNMAEEVKGYADLVQRALPGFVEVKGVTYCGTSAAGSAGLTMQNVPFY
EEIAEFVKELEKELESRGLGYGIAAEHAHSCCILLADKERFKRDGKWVTRIDFEKFFDLH
EGKVEGTRKEVVDGEEKVVGWRPEDYLGDDTPEWALWGNGGFDPRDVRVWRKGKRPKKEK
REGEGCVVNERGGKKEVGAKKGDKAIIEI
>A0A7C0ZTT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVVPQLESILKRQGYYLIGNHSAVKVCYWTKEMLVNRRPCYKSTFYGIRSHRCIQMTPAV
DHCTFSCLHCWRFQGFTNVGFEEDPDDPDFIVEESIKGQRALLSGYKGDPRVPRELFEEA
YDPAHVAISLTGEPTLYPRLPELVRAYHRRGFTTFVVTNGSVPETIERLINEEEPTQLYI
SITAPNEELHRKINVPRIKDSWSRVNRSLELMSTMKARRTIRVTVIKGLNMDEKYVEEYA
KLLEKADPDFIEVKAYMYMGYSRYRLKPENSPKHFEVKEFASKLANAMEYIVASEREDSR
VVLLTKPERERRVNRFLELE
>A0A662GP31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MNAKTKFTKQQIQRYLRAGYRLVGKNTAVEICRWTRTALKGERLCYKRWYGVSSHRCVQM
TPNLNFCNFACSFCWRIHEEGRFKMVPEWDDPKEIVDGIIKAQRELLIGYKGNPKVSQER
FLEAMFPRHVAISLDGEPTMYPYLAELIKEIKNRGMTAFLVTNGSIPARLKELLDKNAEP
TNLYISVYGPNEEIFLKTSKPLIPKAWDLVLESLGLMEEFSCRTVFRMTLVKGLNMVEPE
GYAKLIDYANPKFAELKGYTWVGESQKRLSIQAMPKMEELLDFASKIAELTGYQIKVLDE
KSRIVMLVKDLDVWEWNLKLIKQQRKIEQEHDKKWRGKIKDFRFKTLKSMLSSL
>A0A662JK59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MYLPPNIKSLLVKQRYHLVGPHEHAAVKKCHWLHKALTSRQFCYKSWYGIQSHRCVQFTP
MLSCPNACLHCWRIERGDPGVTWDELKLPPIDDPETLLEGALREQRRIVSGYKSNERVDR
RLYEEALHPKHFAISLAGEPTLYPRIGELLQLLHSKNFTSFLVTNGLYPEVLSNLGVEPS
QLYVSINAPDEETYRRICRPSIKDSWSRLNETLTLLNSFKCPTALRITLIKGVNDHNLEG
YAKLIDKANSLYVEVKAYMYLGFSRYRLRLDNMPRHSEVLNFAERLAQITGYRVIRDSLH
SRVVLLSRIPEPIKVA
>A0A7R8VG26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema douglasi|TrEMBL
MITIFGVPFFGASFIPTLVAVATIYIAWSWFAKKQNGNKICSLEAIDAVTTDSLSRQVVE
NGKGPLISIGDKVGPRKIVAKARKKSCGGKGGKCCGSKKGKSKCLTIEGVIDRLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEETSGQSLCVFVLPTHSEGKPP
EAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQYADHFNEVGRSVDHWLHKLQAV
RVAKLGAGDEDTAASRYGSIEADFDNWQNSLMGCVEKWRAKSNCRCGGKSPPQEERIEEA
SSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNFSSALRAARTRKESEESLGTREM
ITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLA
CANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALDAHYKMINQFKGVPGVKPERLAEGF
QAKHCALSLVGEPIMYPEINKFVKLLHQKEISSFLVTNAQFPEAIREMSPVTQLYVSVDA
STKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYRLTLVKAWNVDELENYAKLVEIG
KPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQKLADLLPEYAIASEHEHSNCVLV
AHKKDYMRKTPDWAVYGSSEQGFDPVETRWHRKSNTKDISGC
>A0A2K6DPY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca nemestrina|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKTQDRSSQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A662J6R1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MYLPPHVRSLLTKQRYHLVGERGHAAVKKCHWLHKALVGGSPCYKSWYGVQSHRCVQFTP
MLSCPNACLHCWRLERGDVEGWDELSIGELDDPEVLIQGALREQLRIVSGYKSNPKVDRM
RLEEARHPKHFAISLAGEPTLYPMIGALIGLLKSKGFTSFLVTNGLYPKTLSSLPYEPSQ
LYVSINAPSEELYRRVCRPSLKDSWTRLMDTLDLVRSFKCPTVLRITLIKGVNDVDLEGY
AKLVERAQPYYVEVKAYMYLGFSRRRLSLENMPRHSEVLEFARSLSQLTGYEFIADSLHS
RVALLSRIGRPIKVSP
>A0A674NPY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
MVHVSGVKIFYGSQTGTAKGFAKELSDEIKALGIPAVVLDMKDYDPDDELAVECTNKSVC
VFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVG
KNVDKWLWMLSGKRIMTRAEGDCNVVKSRNGSVQADFLAWKVKLLKRLQALARGEKKICS
GNCKTEGKCKNKRKVKGEENAALQNNSSEVMIKIMASFVVLMAHCEHSYRIFHRKSVRPF
DSHIPLISLSCAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQNMIRQFRGVPGVKLERYEEGL
EVKHCALSLVGEPIMYPEINTFVRLLHTHNISSFLVTNAQFPQEIRSLVPVTQLYVSVDA
STKDSLKKIDRPLFKDYWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALG
QPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLI
AHTKFKVDGEWWTWIDYERFQELVGVYEKTGGQRSFSALDYMAKTPNWAVFGAQEQGFDP
ADTRFQRRNKTKDISGC
>B2WGI7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora tritici-repentis (strain Pt-1C-BFP)|TrEMBL
MVFLQYAEQLPGELLLIWREHRLEILLSALIVATIARLVIYSRDRRREKLSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLPNVDNHAEDDTAAVRVVSKAKKGPKTVKGRKTQKKNT
APISTFDHKVHKIQPLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQIHDISY
IEHDDFFISPPKADANVKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GVQEALVEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSVVNSSS
APIPVDFTTYKKSAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINDLLSIMHSHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNARGLQYGIGAEHAHSCCVLLADKTRFQKNGKWATRIDFERFFD
LWEGKMEGTRVEGGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKTEEGK
IERELEGESKVQKAKALEF
>A0A059JJB9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichophyton interdigitale (strain MR816)|TrEMBL
MAAMPLQIALSLWHAYRAYILVIIAVALFAGTKFSSQRKQAESQTKGAEQVTQNITVSDN
PVQPGNTSLAKSTPLKSETKPEPKRLRGLRPLKGDANATAKVVSAIRPIFFFTSLTGTTE
KSARAAFESVKSKLQTAPENAQCKVLDPELHDLSYIDFDDYFVTAPKPPTSEPGLSYLYC
IILPSYDIDSIINNFLNHLDETHNDFRIDTSPLSGLTGYSVFGFGDKEGWPTVEEGFCSQ
AVAVDKWLAKLTGKRRAYPLGFGDVKTDGDHSLQEWCDGLVSVLHDIAENGGGLGEGVPG
SGDPIESDEEDAEEDSQRPQNPSRPRRTKARNSQIADLEDIKLNPEDLLDDEPIDFTTYA
PTKISSLSSKEMVPSTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYG
IKSHLCMESTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLR
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINELLSLLHNEHISSFLVCNAQHPDELA
ALQRVTQLYVSIDASNRESLRKIDRPLHRDFWERLQRCLDILREKRNVHRTVYRLTLVKG
FNIEDEVEGYADLVEKGLPCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNE
ELERRGLSYGLSAEHAHSCCVLLASKRFLVNGKWHTRINYERFFELLEREKQTGESFAPE
DYMRETEEWALWGNGGFDPNDQRVHTKGRNKGKIGVPPPSGKVILAGTA
>A0A5E4KZB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MKLIFSGIMIPVSTIDWYGRSASVVFFNGCNFKCLYCSNNKFIKVANQRLEPLYRGGDAV
AIEEIEKQIHDSRMFISAVVLSGGEPTAHPEELEHLARFAKGQGLLVGIETNGYYPERLA
GLIEKKLIDKIFLDIKAPLDDAEKYGMITGGVRDAAERVQRTLDIRDVDIEVRTTVFRSF
ADVSAIARSLSGRDIIYVIQQGRPEYAPEEKLRKENPFTREELMDLAGSVSFLKDVRIRT
REKGEERIV
>G8B526|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida parapsilosis (strain CDC 317 / ATCC MYA-4646)|TrEMBL
MSSGSLILSICASLYLYNGGRWTIVLSAFVLSYLYKLERKSTTVTPPPITESVLEDSSQS
PIYAVDFTSTTFTPSATTNIPKTVRSRAKRSPKIIKASKPTPPQQSNEPILTKSQVDLKK
SQIYIFYTTLTGSSLRLAKNLYDKLSQMELSHEPKLLSLDDDVDDLEKYFLKTPKDDDNT
KSIYLLVLPSYETDSPIDYFLEHLIDTYQDFRVDKYPLRSILGFAVLGTGDSESWSGDKF
CYQAKLADKWLGKLGGRRLYPLGEVCMKYEGEPKAKEWIQNFAELLVDEEPFYIDENNDD
EFDDSDKEDNSDDANTLVDVEDMGDIIRKTGQRSTQQMEVKQMVAKGSPTFKTLTKQGYT
IVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNP
VAKSNWRWELDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFQEAFKVKHCALSLVGEPI
FYPHINEFVGMLHQQHISSFLVCNAQHPDNLAKLSKVTQLYVSIDAPTKTDLKKVDRPLN
SDFWERLMSCLDILRTTQSHQRTVFRLTLVKGFNMTDIKSYADMVERALPSQIEIKGATF
CGSSNGNGNPLTMQNIPFYEECKEFVRSLSDELRARNLGYDIAAEHAHSCCILVAHEKFK
INGVWHTHIDYPKFFELLESGKDFVDIDYVKPTPEWAVWGSEEAGFNPVDTRWDRKAEKL
KNKLAREEEAKRKEQIPMEVI
>A0A8J7RJ19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus voltae|TrEMBL
MENNIDNKNNKNNKNNYSNLKKDKKSQKIQNLEKRIPQIPEQLYNILRKQHYQIEDHSAV
KLCGWVRKSFLEDKVCYKSKFYGINTHRCIQGTPSVIWCQQQCEFCWRVLPSDLGINEPN
FKAPKWKEPEEVAEDILKMHKTIITGYKGIIDRIGTEKYKEATEPKHVALSLAGEPTMYP
YIDELINIFHKKKISTFVVSNGILTDVIEKINPTQLYVSLDAYDLPSYKKICRGTEQDWQ
SILNTLDVLGEKGRTCLRTTVIKNINDDLSKFTELYDRANVNFIEVKSYMNVGYSRNRLN
LDDMIKHDDLISMCNNIEDKSIFKVIDDAPESRVVLLSNTKDDRVVNPKIDFENL
>A0A1Y2TWN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypoxylon sp. EC38|TrEMBL
MASRVGGLGADANAPFQSILELWHEHRLAILFATTCILTVVWLYIEPRQEVKLRIETHKS
IQGATKPIADDEPKALEEKVLVRTEKIKDATTGPRRIKGEIRRADTARQIPEHNPERPIQ
ILVFYSSLTGSTERTASGFAQNLGASFGAQVDGSGKSFLSPIVLDLAEVDYDEYFISVPK
PADPNTSVDYFYLLLVPSYNIDSINDNFLEHMKETCHDFRIDTSSLSGVLGYSVFGFGDR
EGWPTEDEGFCFQAKEVDKWMARLTGRKRAYPLGMADTKRDLRQRLDEWTDGVKDTLMHI
ARTGSLGEGVPGSGDAVESDDEYGSADDDDGEVIIEQSAATRKSKKARPGNIDDVEDLGR
IMKASQNSSEKSNNPTAIAVDFTTYNKPTSKRPIQTIKEMVPKNSPTYASLTKQGYSIVG
SHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPEMIFDGVKAGHYKKIKMLRGIPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLALLHGERISSFLVCNAQHPEQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFW
ERFQRCLDILREKRFKQRTVFRLTLVKGFNVEDEVEGYADLVEKGLPCFVEIKGVTYCGT
SSSAGAGLSMANVPFYAEVTEFVTALEKKLRERGLAYGIAAEHAHSCCVLIASERFKVDG
KWHTRIDYQRFFELLEERGADGDWTPEEYMGPETPEWATWGNGGFDPRDVRVDRKGRKIE
TS
>A0A8C2GNK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKVIKFLTACVIVIIIYLSNLKNYMQLCCDVFLAGDVIAQGIQCEVMDMKEYDPEDRL
AEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNS
VYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQA
LAKGEKKACSGKCKSASCKNKKKHKEEAEDSQSHAEKNNSEASQPSSLMKSESEEERREM
ITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGL
TVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALG
QPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLL
AHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDP
SDTRFQRKNKTKDISGC
>A0A7C5RP01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MAGTVVETRKIVRLEVKGAEKFLRSGYRLVGRHSAVKICHWTKSALRGGKSCYKSWYGVE
SHRCLQMTPSLQYCNMACVFCWRFHTINRGQPYSGEWDPPETLLDAMIREQRQLLSGFKG
NPRVERRKFIEAMTPTNIAISLDGEPTIYPYLVEFIKLARSRGMTTFLVTNGTMPERLDE
LLEKDAEPTNLYISFYGPDKETHLSVNKPMIPDSWERVWRSLSLMPRFRCRKVIRLTLVK
YLNLKSPEKYAEAIRLAKPDFVECKGYVHVGESQKRLKKEHMPTMEDLMSFAQELSRLTG
YVYATHDEVSRVVLLADPTSPYYIEAKERLGLTQSGVGELAVSCSDNIF
>A0A846PW68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSCSGETIEEEQLIKIKPLIVKQLKKAKYGVSDHSTVGLCHWTKKSFRNEGSCYKHKFYG
ISTHACMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPEHVAEPEVIMSKLMEERKNLIMG
HKGDPRSDERLIYESLKPSHYAISLSGEPTMYPKLPELIKYLKTLEETKSIFLVTNGQEP
EMILKLQKENALPTQLYLSTNAADYESFIRINKPKYDDSWERWNATLQMLKNLDTRTVLR
ITLIRDYNNQKEMIPAFAKLLEESSPNFVEIKSYMHIGRSTNRLQHENMLDMEEVREFSK
EVTKHTKNFSIMDESYISRIVILQNNERKIDRWIATYQNTN
>A0A8J8JLP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. Bubb.Bath|TrEMBL
MAITFASNPNMPEEIAALFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGMP
RINMKKFEEAWNPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
KEDKLPSQLYVSLTAPDIETYNRVNVPMIPDGWDRIKQTLKLMNDAQTRTVIRMTLVKGE
NMNNPRGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELLKYLPGY
HLEDEYEPSRVVLLMRDDVDPNGRGLNGRFVKF
>I3RG08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus sp. ST04|TrEMBL
MNIKPGKITVQANPNMPKEIAELFKKQHYELVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGVELPQPWDDPSFIVEESIKAQRKLLVG
YKGNPKVDKKKFEEAWEPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPER
LKEMIREDKLPTQLYVSITAPDIETYNRVNIPMIPDGWERIMEFLELMKDAQTRTVVRLT
LVKGENMHSPENYAKLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHEEIKQFAEALVK
HLPGYHIEDEYAPSRVVLIMRDDIDPAGTGLEGRFIKH
>A0A329T3X5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora cactorum|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLQTHPRTLPSSNAAATLPKRKAKKMPHQNAKTNSDPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKVFCNWITDMTQDFRVSKNWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVALGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKTSSPVKDD
QTAKKWLSQKEFRRQNRAKKAEANGEKVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHSHSNCVLIAKKKFCRDGVWHTWIDYERFHELIAKYYEDGTPFT
ADDYTAPTPYWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A7K4CL03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MDSPDNIDGIEAKKTLAKQGYHLVGSGAVKPCLWLNRSMRGGDQCYKHHFYGISSHRCVQ
MTPTLRCNHLCLYCWRPIDSVLPEEEPMEPAALLDGILHEQQRILSGYGGAKTTDRSRLK
EALEPKHVAISLMGEPTIYPYLQELIDLISRRKMTSFLVSNGTNPEVLESIRPTQLYISL
NAPDEGMYRRISQPNGPFWPKIQESLSILKNHNCRSVVRMTVARGLNMERPVDFARLLES
AEPDFVEVKAYMHLGRSRTRLDRQAMPDHAEVLSFARALGNEMGYELSMDVPLSRVALLS
SGRICRSLDS
>A0A395RXW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sporotrichioides|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAVRIYFQFNSQNTEVIAFKKA
YEEPAKPKVAVEEAKVEQVEIEENTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDLTRPVVPLVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKAHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMARLTGRKRAYPVGMGDMQSDHEERLQEWAQGVEE
VIEYVARTGNLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDAADKKTKGGRDLDDVED
LGRMIQKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A2K6TFV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saimiri boliviensis boliviensis|TrEMBL
MDPSMDTWDLSSPLIPLWINRFYIYLGFAFSISLWICVQIVIKRQDRNLQENSFPKATQD
LMTNGFVSLHKKDIFVSGVKIFYGSQTGTAKGFAAVLAEAVVPLDLPVAVINLKEYDPDD
CLIEEATGKNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVSRGEGDCDVVKSKHGSIEADFGAWKTTFISQL
QALQNGEGRKSCGGHCKKGKCDSHQHGSEEREDGREEQDESRHRDAEEEEPYEGSSEEEF
GGEDQQSVNSIVDVEDLGKIMDHLKKEKREKEEQEEKTSLFGNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINSFLKLLHQRKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KVGSEWWTWINYNRFQELVEEYEDSGGSKAFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAVSGC
>I7ZT44|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus oryzae (strain 3.042)|TrEMBL
MAELSLAEGLVTFWHSYRLPILIATASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A7J2LLR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MIPDELRKVLEKQQYAFIGRHSAIKICYWTKKSLLDEGVCYKQQFYGIKSHRCCQMSPSI
GFCPNRCIFCWRPIEYTIGSVLPDKNVDDPDELIKNAITMQRRQLIGFKGNPKTNMKKFA
EAMEPMHFAISLAGEPTAYPKLAELIEKLHGLGKTTFVVSNGMFPDRLAEINPTQLYVSI
SAPNEELFKKISQPQLRNGWDLLMKSLNVLRQKRDKTRTTLRITLIKGWNMVEPENYAEL
IKLAKPLFVEVKAYMHVGFSSYRLSPTNMPFHQDVKEFAELISAESGYRFIDENSASRVV
LLMEKDFEGRIMRFE
>A0A559LEY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. cubense|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A4U0V008|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Friedmanniomyces endolithicus|TrEMBL
MYIYPLIFYYTLGGTTRVYAEHQASLLSSTSERILKPEVLDLAQIDYDDYFISPPKSPNA
NTALFYILLVPSYDIDTELSNFLAHLRETHHDFRIDTAPLAGLAGYAVFGVGDSREWRTE
REGYCKDAIDVDKWMARLTGGRRGFPLGQGDTGSDGGVKKTLEEWTKGIKGMISGLAKGE
GLGEGMKGSGEAIESEDEDGDDEAESGALVLENGRAENPESVRKPSKRSQTDDLEDLRAP
IPVDFTTTRPSSKTIAPPPKAMVPVNSPTYNSLTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPDLVFAGMKE
GHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLAMLHSERISSFLV
CNAQHPDQLAALGPVTQLYVSIDASNKDSLRRIDRPLHRDFWERFLRCMDILREKRFTHR
TVFRLTLVKGFNIEEEAEGYADLVARALPAFVEVKGVTYCGTSTAAGAGLSMGNVPFYEE
VQAFVLSLEAALLRRGLEYGIAAEHAHSCCVLLADRGRFFKRAEGDEGGERKWHTLIDYA
AFFRCLESGKAFGPEDYIGEPTPEWAAWGRGGFDPRDERVDRKGRPKAVEVVE
>A0A2J6GXZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MVSEKSKANLEKQQYEFIGSHSAVKICDWTKKSIRGEGTCYKEKFYGIRAHLCCQMSVSV
DFCQHACQFCWRELGETKIVMDGVVDDPKSVFEKSGPAQAHQLVGFYGNEKADKKKLDEA
KDPMHYAISLTGDALIYPKLNEFIKKLHENGKTTFVVTNGMLPEKIESMEMPTQLYISVD
APNKEVYKEIDRPLYIDGWERLQKTLEVLKTLKSKTRTTLRLTIIKGMNDFDVDGWAEQI
LKSDPTFIEVKAYMFIGSSRQRLTIENMPRHLEIVEFAKKLCEKTGYKIIDEQVSSRVVL
LMKEDLPDRIMKFD
>A0A8J8DUI8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 18S1|TrEMBL
MALTFKSNPNMPEEITGLFKKQHYALVGRHSSVKLCHWLKESIKKDRFCYKQKFYNIHSH
RCLQMTPVTAWCSHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQFYVSLTAPDIETYNRVNVPMVPDGWEKIKETLRLMKDAQTRTVIRLTLVKDE
NMHSPEGYAELIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTGIGGRFIKH
>Q2NEJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)|TrEMBL
MIISQTKQKDLEKKGYRFAGKNIHAANKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PAIAYCQHKCLFCWRDTDITKTSWDSDDYDDPKTIIEDCIENQKKLLCGFFGNENANPEK
LEECVKPNNAALSLAGEPLLYPEINQLIEEFHKQNFTTFLVSNGENPDKIEALGKHEPTQ
LYISLDAPNKEIYKKVCKPQVSNGWEKLQESLELLSTIDTRKVLRITSVKDLNMIHTEEY
AKIIEKADVDYVEIKAYMFVGDSRNRLQWENMPKTVDIQEFAQSIAEKTSMDIIDEVEKS
RVLLLGEKKPGKYNN
>A0A060RUL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium reichenowi|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINEIINKNIYINNINGSIHYDDILLKKDYIEKKIQINESYKNNDNVDDSNIDGNIIHK
NNCVNNWLDIKDMNSLENEIIEYFKLRFDKYQVNNKKRKEKISRSNYENMVPLYYNKNIN
YLEPYEENVKMFNSKFKNYIDCTIYNKNIGKIYFNLIDANNHDYYSFFDNTENYNLNVLF
FFISTSSYGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPI
KKCEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYCFNYMKRWYMN
KRIYDTLSYYCYFFSNYTNFNVNQTEQIKYYMHDQKSESEKKKKKKKKKEKEKGDLSIYP
MEQLEACHCNKPYQENDLSIDQSNINYNNNKCCNNEIYNTHNDIYDNDKDDHQISLSNMG
NDEKDFVNEHKTKVDKTNEMMNEKREEVYVRGDTQGVEGCTNCNCQSVNEYNDTSNTNIM
NNKNNMNNKNNVNNKNNVNNKNNVNNKNNVNNKNNVNNPNNIMTGENSMSESETSSNQSY
PDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHK
AMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNA
QFPVELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRF
TLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAW
NLINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNAL
DYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A8D2I837|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Urocitellus parryii|TrEMBL
MDFVHLFIFKGKSSQERSIPEAAQDLMTNDYASLPKKHIFVSGVKIFYGSQTGTAKGFAT
ILTKAVTSLDLPVAVINLKEYDPDDHLVEEIASKSVCAFLVATYTDGRPTESAEWFCKWL
QEASSDFRFGRTYLKGMRYAVFGLGNSAYESHFNKVGKNVDKWLWMLGARRVLARGDGDC
DAVRSKHGSIEADFRAWKTRFISRLQALQKGETSCGGNCRRGKCESKQHGTEDEEPEPHA
LAAQQPRDTEEEEPCESSSEEEFGAGEHQGPNSVVDVEDLGKVMDLVKKEKREEEQQEEK
GLFGSRGKKEGGEGRAMLTPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEIILEGAVENHLDMMK
QFRGVPGVKAERFEEGMEVKHCALSLVGEPIMYPEINRFLQLLHQRKISSFLVTNAQFPE
EIRKLKPVTQLYVSVDASTKDSLRKIDRPLFKDFWTRFLDSLKALAEKQQRTVYRLTLVK
SWNVDELQAYAELVSLGSPDFIEVKGVTYCGESAASSLTMANVPWHEEVVRFVRELVGLI
PDYEIACEHEHSNCLLVAHRRFKIEGEWWTWIDYSRFQELVQEYEDSGGSKSFSAEDYMA
KTPPWALFGARERGFDPKDTRHQRKNKSKDVSGC
>A0A2K3J0W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon M9B1D|TrEMBL
MQEEFKKILKKQHYAIVGNHSGVKLCHWMRQSLLFNRVCYKQDFYGIESHRCLQMTPSIN
QCNHMCLFCWRHQGFTEKNFNEIDDPKLILDESIKAQMKLITGFKGDNRCDQMKWKEANN
PNMLACSLSGEPTLYPCLGEFFEECHKRKITTFLVTNGTNPEALENLNPLPKQLYVSIVA
PNKKIYEKICSPLISNAWDKINQTLELLPSLKTRTVIRHTLVKGWNMDEKLIKEYAKLDS
KANPLFIEPKGYVFVGYSRKRMNISNMPSYENVKDFSDKLNEELGYNFLMEKSDSRVVLL
SKSLKPARFDK
>A0A7J3DA49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MKSELLTILEKQQYKVYHEHAAVKLCHWVRESLLRNRFCYKQDFYGIKSHRCLQMTPVVN
MCTQSCLFCWRVQGFESSPSSWCDPEEMLDALIEQQRLLVSGFKGDKRCAIERWQEAREP
KHIAISLAGEPTLYPFLSDFIEVCHTRGLTTFLVTNGTNPEVLQQLDPLPTQLYVTVAAP
NEEIYKKLCIPKIPDGWERLMSTLELLPSLNARTVIRHTLVQDWNLGWEEEYARLDEIAD
PTFIEPKGYVFVGQSRERMSLTNMPSHASIRDFGRRLGNLLGLEILKEKEDSRVVLLGEK
GRESKIPNIE
>A0A8H4PGN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium albosuccineum|TrEMBL
MNPMFSDHGQEHLSSPILFLNCGCRLTNPSYLRRRVPRIDSFSARSQQKGRQDGLGKLFV
ALAAGLVCRRQVPDCAALSRVAQPADSNSDLVDVWHVHRAPILLVVLVVLGAARIYLHIN
GQKTELIALKRKFEEPPTPKAVIEVKTPAAVETIDEKKDVKTQGPRRIKGGLARKPSKNK
EEEKDLARPVTILIFFSSITTKTDKIAQAYLKELEGKLEQLSKQSGRQFHKPELRDLTEI
DFDDYFIAPSKSHGDVDLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGY
SVFGFGDKENWPTEGEGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMKSDHEQRLQEWTGG
VEEIIEHVARTGNLGEGLPGSGAAEESDVEDIAEDEDDGEVLFEDDETDDTKKKTNGRPL
DDVEDLGRMIRKDDNSTGTQKAPLAIDFTTYGSSTKKTAPQGPKEMVAKNSPTYAALTKQ
GYAIVGSHSGVKTCRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGE
PIFYPHINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRP
LHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEIKG
VTYCGTSTSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASE
RFYVDGKWHTLIDYKKFFDLLEERGPDGDWTPEDYMGEATPEWATWGNGGFDPRDDRVDR
KGRKIAAS
>A0A7J6N8S1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus olseni|TrEMBL
MPSTTTPTPALRYFKLPNKDRYAPAQVLRSSDSGHAMFIIVEAHIATVCAPLLGDSVHYF
NLDNRPFLGAWIPSSHKTQLAPEDVPVDLEIPTAPDNFDIETSEDDENDNREFLSYSSRH
PATPENATTGTSQSPAVSPSPQGVTAGAPVSTSGVFFEDPLFVVLPNHESPVEGKTIHHA
RTAANAVPIPNGKVFTGIDDQRPISDILPAEGQGERGSKFDRGRSTKVDFVADVDLLGSI
SESFPCTISIISHVFLCISSNALHIELSWNGVGYTVGFSIIITIPHFMLAGGFYHALLSK
HYSGPSRTVKVVYSSRTGTSKAAAGRLKDTLESDKIRVILLPIEQYSYEELCEESYLVLL
LSTDTDGTPLPGAKDFTEQLRDAVYDFRVDKNLLEKCRVAVIGFGSEEYPAKHYCKVAKN
CDDWLAKLGAQRVTPLLCISDTRDVEKQVGRCIDLIKKAYARLDAEPTDQRTADLEDDVE
SVGSEESTSDTEDGDVEDASGACGSNNKEMVTKKHRAALTREGYRLVGSHSAVKLCRWTK
HQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPVGRSWTWAQDPPEEI
VNGWLGNHAGMIKELRGVPGVTPERFEQAKRVRHCALSLVGEPIIYPQINTALDLLHQNG
ISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAKDMKAIDRPLFEDFWDRFIDSLTALKH
KKQRTVYRMTLVKGYNISTAAEYAELLHLGNPHFLEIKAVTFCGKGDGSAQMTMENMMIE
SSPWVKERYEIACTHRHSCTVLIAQKSFKVDGVWHTWIDYDKFTQLALEYSKTGKPFAVE
DYWAPTPAWAVYGAEEEGFDPEMKRHYRNGKTPELGKQIRAKQLREEQERSSKCGEGTEC
CGGGCREE
>T1E4C1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crotalus horridus|TrEMBL
MDTPADTWDNFHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKVKEQNKNRLAELNLPK
ITAAEKEQDPSLDKVHVAGVKVFYGSQTGTAKRFALVLTEAVATINLPAEIIDMQDYDPD
DSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFGL
GNSVYADHFNTVSRNIDKWLWMLGAQRILSCARGDSNVVKSQHGSIEADFEAWKAKLLTR
VQAVAKGDQKACSGTCKKGRCRSKPKVREEAKEPETSKHAEKEEEDLFETTSEEESDIEN
GRGADQVVDVEDLGKMMGHMKKSQKEHQTDGEVPIGVGTQHGKGEDGRREMITPALREAL
TKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNLIKQFKGVPGVRNDRFREGMEAKHCALSL
VGEPIMYPQINQFLKLLHHHNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQRFLDSLQALAEKQQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIKG
VTYCGESSASSLTMANVPWHEEVKRFVQDLADLLPDYEIASEHEHSNCLLIAHKKFKIEG
KWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKERGFDPMDTRFQRKN
KIKDISGC
>A0A4D9AVM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salvia splendens|TrEMBL
MPLPSSLSLPPARITLLTLLSASAALYFLHKSLNRRRLRLRAAAVATGCGCHNHAPPKRG
KLFFLSQTNTSKALAQRLHALLTLSDIPFDLVDPKDYEPEDLCKETLVLVVASTWENGGP
PQDGAFLVNWLAESAEDFRVGSLVLKECRFAVFGVGSGSYGETFNAVARDVSAKLRKLGG
RELVELGEGDVDLGDLDGVFDRWSQKIIGVLNGSVVENGQGYENYVAGSESEGEYSEEDD
EDVEESDVVDLEDIAGKGPSRRSAVEAKANGKVNGHAANGEKEMVTPVIRANLEKQGYKV
IGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GKSWQWKMDDPLVIVDTAIDLHKKMIKQMKGVPGVKAELLAEGLSPRHCALSLVGEPIMY
PEINTLVDELHRRHISTFLVTNAQFPEKIMALKPITQLYVSVDAATKDSLKAIDRPLFSD
FWERFLDSLKALKEKQQRTVYRLTLVKGWNTEDIDAYSSLFDVGNPDFIEIKGVTYCGSS
ATSKLTMENVPWHKDVKEFSEAIARKSNGAYEVACEHVHSCCVLLAKVDKFKVNGQWHTW
IDYEKFHNLVLAGEPFTSNDYMAPTPSWAVYGAEEGGFDPKQSRYRKERHHKSAR
>A0A2R6N312|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_8_66_22|TrEMBL
MSDSESGPRQVDDPDYHSVNHTATQTCGWTKNALRGDGKCYKNIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQTELLSGFGGNDQVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTKPDVLDECDPTQLYVSVDA
PDRGTFDSTVKAVEDDAWERLIDTLDVLAAKDETRTVIRTTLVKGHNMHRPEWYAAMCDR
ADADYVELKAYMHVGHSRGRLDRDSMPDHEEVVAFAEEMREFLPHDELKQVPASRVALLA
RESETWIPKLQKSSDFWARDPLAE
>A0A497GYQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MRVPEEVVRRLRKQGYYIVGRHSAVKLCHWTKERLKGGKPCYKGTFYGIQSHRCLQMTPA
LFNCNLNCLYCWRMHNFVDAIVEDPDDPAFIVEESIKGQRVLLSGYKGNPKVPRRLWEEA
QEPKHMAISLTGEPTLYPRLGELIEEAHKRGMTTFLVTNGTTPEVLRDLDPLPTQLYVTV
AAPNEEVFRRLQLPPRPGLWQKLMETLELLPSLDTRITIRHTLVEGWNLGYVDEYAKLDE
KADPDFIEPKGYMYVGWSRLRLRAENMPTHERIMWFARELAERLGYRIYAERPESRVAML
TKHDDESKIKLRLQ
>A0A849Q2W9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNKDLRRILEKQKYRVVGDHSGVKVCHWLGQRLIHNRSCYKERFYGINSHRCLQMTPAVN
DCTQMCLFCWRFQGFGSTLPEVHDDPEEVLEGCLKAHRNLIQGFKGDPRCSPEDFAEAME
PNQVACSLSGEPTLYSHLGELFEACHDRGMTTFLVTNGTRPDVLAELDPLPTQLYVSVVA
PDAETHRKLCAPFEVSAWDDLMRTLDLLPSLDTRTVIRHTLVAGYNMGNEESYSRLIERA
DPDFVEAKGYVFVGDSRRRMTLDNMPSHDAVRAFSKRLAGLSGYEVRNEQHSSRVVLLAR
PGMGSTRIDGK
>A0A662KZ40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MEENIRRLFERQGYKVVGEHSAVKLCHWLREAIVGGESCYKSQFYGIKTHRCLQMSPAAT
VCTQECLFCWRYQGYMGDVKKWDEPEYILEGAIEAQRKLLSGYKGYEKTVIELWKEANEP
KHVAISLTGEPTLYPYLGDFIELCHKRGMTTFLVTNGTRPDVLEKLDPLPTQLYVTIAAP
DEYVYKKLQRPKIKDGWGRIMKTIDLLPSLDTRKVIRHTLVRHWNMKDVDTYAKIDERSE
ADFIEPKAYMFVGYSRERLSIDNMPSHKEILNFAHQLSSLLGYDIIGENKRSRVALLSRG
SKSPLISINYTKHPQYQPSSV
>A0A640W417|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MEEEKKILRKQGYAIVGRHSAVKPCHWLRQSLLYGRQCYKHTFYGIESHRCLQMTPTAFH
CNQRCLYCWRYQAFPLAAFPKDMADEPSYICEESIKAQKRLLSGYKGDARVDIKKWEEAL
QPKHVACSLIGEPTLYPYLDQFFEECHKRGMTTFLVTNGTMPEVLEKMDTLPTQLYVSIT
APNEEIYQKLNNPLIKHGWERINKTLELLPSLNTRTVIRHTLVKGWNLGYEEQYAKLIEK
AEPWFVEPKGYVYVGYSRERLTMENMPSHDEIKKFASRLAELTGYEIEDERADSRVVLLG
RGRKRMIK
>A0A7J3U665|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MDEQLKRIFEKQGYTVVGKHSAVKHCHWVRKSLLFNIPCYKQTFYGIESHRCLQMTPAAN
QCTQKCLFCWRYQGFTEVKIDEKDADDPEFIFEKSLEAHRQQVSGFKGDDRCDKKKWEEA
RNPKHVACSLTGEPTLYPFLSEFFEICHRHGMTTFLVTNGTMPEVLENMDTLPTQLYVSL
SAPNEEIYKKLNCPLIKQGWKRLNRTLEILPSLDTRTVIRHTLVDGWNLGYEEEYAKLDG
KAEPWFIEPKGYVHVGYSRERLNTENMPRHEKIRNFGKKLASLTGYEFLDEREDSRVVLL
GRRKERMI
>A0A7J3TLD0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MQPLQELQKILRTQGYAIVGKHSAVKLCHWLRRSLLENRACYKNTFYGIESHRCMQMTPA
AFHCTQKCLYCWRFQGFTLTELSEIDEPSYILEKSIEEQRRLLTGYKGDERVDLKKWREA
IQPKHVACSLTGEPTLYPRLSEFFEECHKRGMTTFLVTNGTNPEAIENMDVLPTQLYVTV
AAPNEEIYKKLCVPLVAKGWEKLNETLELLPSLDTRTVIRHTLVKGWNLGYEKEYAKLIE
KAEPWFIEPKGYMYVGYSRQRMSMNNMPSHEEIKEFAQKLAELTGYKIEAERGDSRVVLL
GRGKERKIK
>D0KTS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharolobus solfataricus (strain 98/2)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHRKAVSG
YLGRNDVSIQKVKDAMKPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAKEFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKILGQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWNWSTIDMEDDMSGEYKEAEQGCTEGS
T
>C4JQR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Uncinocarpus reesii (strain UAMH 1704)|TrEMBL
MADDTYATGAQRALSLWHSYRGYALALVPTIFILSRLISARKTATETPPPLAPPPAAKNP
RRPGLVKPNSPATSRPEEGATSPNEALKTKIKTVPKRVVGTRPQKKRARSTVDGLDTVKE
TLVQPIIFFSSLTGSTERSAKRVVEQLQREPQRDGRRSSRLLDPQLHDLSYIDFDDYFVS
PPKPPVSNLNVLHFYCIIVPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYTVFGF
GDREGWPTEEAGFCSQAKEVDRWLAKLTGKKRAYPLGLGDVKSDGEKALDEWCAGVQEVL
CDMAANGGALGEGVPGSGEPLESDEEDVEDDEHASNTGSGRRKTLRGDIADLEDIKVSAD
GSAKLDAVFPVDFTTYSKSTPISPPIPKEMVPTTSPTYAALTKQGYTIIGSHSGVKICRW
TKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPE
LIFQGAKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVSLLHK
EHISSFLVCNAQHPDQLAALHRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDIL
REKRHFQRTVYRLTLVKGFNIEDEAVGYADLVEKGLPCFVEIKGVTYCGTSTSAGAGLTM
QNVPFYEEVAAFTVALNDELNRRGLGYGIAAEHSHSCCILLASHRFYVNDKWHTKINYKR
FFELLEKENTDGEAFTPEDYMSETDEWALWGNGGFDPKDQRVYRKGKNKGNTADAAPALE
VVAA
>B3LKM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain RM11-1a)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A7J4NP94|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MEPTIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSETLNKVDSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NQEIFNRICKPKFDSHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDVMSFSNSLAPLVGREVLSDRRESRVALIGK
EMIPVTLPEKTRDLPANLGIAKPQNFKLPSL
>A0A7J4SM88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon|TrEMBL
MSCPDGPKQVDYPNYHHIGHTAAQTCGWTANALRGQGKCYKNIFYGIESHRCIQMTPIVK
CNERCVFCWRDHRGHAYELDNVEWDDPSAVADASIILQKKILSGFGGNQHVSPETFQQAM
NPRHVAISLDGEPTLYPYLPELIEEFHSRNMSTFLVSNGTNPDMIKECEPTQLYISVDAA
ERSTFDRVVRPVEKNAWEQLIDTMDILHKKSCRTVLRTTLLRGWNMENPDWYAAFYERAD
PDFIELKAYMHVGHSRDRLSRDIMPETQEIVDFAKEVGSYLPEHTTLKTVPISRVVLLSK
HEETWIPMLKKSSSFWKNETVAYAE
>A0A0V0TGC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella murrelli|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEDDNFDHIQSDFFKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENEN
SSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKI
CRWSKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTD
PAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISK
MHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSI
DILRGKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSKDSKITMAN
VPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAE
RFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A4Q4VG64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. MC13-8B|TrEMBL
MSATFWGSVADGSRGLTAVLFAVWLYLQLSQRQEKSAGSPKLESGKSLPVELVAEEKISL
STTKESSSGPRRIKGELRKANGPKSAVHLAPQWRVQILVFFSSLTGSTERTAKQFAATLE
ASLLDQTSESDRVFLKPQLLDLTQIDYDEFFISPPKSAEASQPVDYFYLILLPSYNIDTM
NDNLLEHLKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQAKEVDKWMAKL
TGRKRAYPLGMGDPKGDLKERLAEWTGGVTEVVRQIAKTGCLGDGVPGSGDAVESDDEYV
SGEDDEGDVVVDEPVKPKNFKKSTRDIDDVEDLGRIMKSSRADANDTTGRAPIAVDFTTY
SKTSKKPPQTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKM
MRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHGERISSFLVCNAQHPDQ
LAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDILRERRFRQRTVFRLTLV
KGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSGGKDGGGLSMANVPFYAEVTAFV
EALDRRLRERGLGYGIAAEHAHSCCVLLASERFRVEGRWHTRIDYDRFFELLEERGPDGE
WTPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A7K8GAE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orthonyx spaldingii|TrEMBL
LDASMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIAIQFTTTRTKRKKSRGNSASSEG
TAGKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAETVTSLNLPVEVINMGDYD
PEDALSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNRVGRRIDRWLWMLSASRIMTRAEGDCNVAQSRHGSIEADFEAWQAKFL
TRLQALCKGEKKACSGKCKKGKCKSSGKQSKESSDHEYGTSEHENTEAEEFETSSEEEAG
GTESVIDVEDLGNIMGHVKKAKVLLLEGVWDGAAGMGRKEEAERREMITPALRDALTKQG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILQEAVENHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTQESLRRIDRPL
FKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDFVEVKGVTYC
GESSASSLTMANVPWHGEVVGFVQELARLLPEYGIACEHEHSNCLLLAHCKFQVDGEWRT
WIDYGRFQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARD
ISGC
>T5BGJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blastomyces dermatitidis ATCC 26199|TrEMBL
MAWEDLGIVARGLLTLWHRYRAPIFLLAAVIFTVVWLAPRNSQPNTPEPDSLPASLNKNQ
NQNAKSELESFSSNDQAAGDLPKRHRSRSSSVDNRPKQVTQPANGPKRVRGIKPEKNGAK
HQIGGGGLPRGIVIQPLVFYASLTGATETYAKSFCDRLQKASHPLLENNGKTNILPPELH
DLSYIELDDYFITAPKPPESAPNTRFLYCILIPTYNIDTMINTFLGHLEDTHNDFRIDTS
ALSGLVGYSVFGFGDREGWPTEEEGFCSQAKAVDRWMAKLTGKKRTYPLGMVDVKGDNIQ
KVLNEWCDGLTDVMFDVMTSGGLGEGVRGSGDPVESDEEDIDDDGEDINENGENRRNKGK
NEQIMDLEDINFGGSNSRNAFANAQPLPVDFTTQSRAQASKPASQLEMVPTSSPTYAALT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWR
HGTNPVGTTWRWKVDPPDLIFDGVKAEHYKKIKMLRGVPGVRAERFAEAMSIRHCALSLV
GEPIFYPHINKFLSLLHNDRISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKID
RPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAAGYADLVEKGLPCFVEV
KGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELTRRGLGYGIAAEHKHSCCALLA
SNRFYVNDRWHTRIDYDKFFTLLEKEKNEGIPFRPEDYMRETEEWALWGNGGFDPKDTRV
HTRGRNKAKLNAALKEAQDASVSAEG
>H1W4B0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum higginsianum (strain IMI 349063)|TrEMBL
MASSLQSAGFKDVLNNAYDVWQQVRIPVILFAAFGLLVLRFYLHSTDEKGELKALPKVYN
TEKPQSKPIDEKKDVKKDEKKDIKQSSSDSVTESKAPKSNGPRRIKGGLVKRVSSDSANA
ETLVRKIRPLVFFSSITANTPKIAKEYAERLEKELQRSATGTGCSFTTPEVLDLADVDFD
DYFITPPKSENDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSV
FGFGDREGWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVV
DVLTMLAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLIEDSEAKPEKLKNRKNIDDVED
LGRIMKSSSPDTDTTNRTAAAPIAVDFTSYGKTTQKKTPMSAAKEMVPKNSPTYASLTKQ
GYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRP
LHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKG
VTYCGTSTASNAGLSMSNVPFYWEVAEFVKALEKRLNEKGLKYGIAAEHAHSCCVLLASE
RFYVDGKWHPRIDYQRFFELLEERGPDGNWKPEDYMGEATPEWATWGNGGFDPRDERVDR
KGRKIES
>C5GJ95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)|TrEMBL
MAWEDLGIVARGLLTLWHRYRAPIFLLAAVIFTVVWLAPRNSQPNTPEPDSLPASQNKNQ
NQNAKSELESFSSNDQAAADLPKRHRSRSSSVDNRPKQVTQPANGPKRVRGIKPEKNGAK
HQIGGGGLPRGIVIQPLVFYASLTGATETYAKSFCDRLQKASHPLLENNGKTNILPPELH
DLSYIELDDYFITAPKPPESAPNTRFLYCILIPTYNIDTMINTFLGHLDDTHNDFRIDTS
ALSGLVGYSVFGFGDREGWPTEEEGFCSQAKAVDRWMAKLTGKKRTYPLGMVDVKGDNIQ
KVLNEWCDGLTDVMFDVMTSGGLGEGVRGSGDPVESDEEDIDDDGEDINENGVNRRNKGK
NEQIMDLEDINFGGSNSRNAFANAQPLPVDFTTQSRAQASKPASQLEMVPTSSPTYAALT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWR
HGTNPVGTTWRWKVDPPDLIFDGVKAEHYKKIKMLRGVPGVRAERFAEAMSIRHCALSLV
GEPIFYPHINKFLSLLHNDRISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKID
RPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAAGYADLVEKGLPCFVEV
KGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELTRRGLGYGIAAEHKHSCCALLA
SNRFYVNDRWHTRIDYDKFFTLLEKEKNEGIPFRPEDYMRETEEWALWGNGGFDPKDTRV
HTRGRNKAKLNAALKEAQDASVSAKG
>A0A8D0SSZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPQWALFGASERGFDPKDTRYQR
KNKAKDISGC
>A0A0A7V7R6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosopelagicus brevis|TrEMBL
MSCSGEIVEKNEQLIQIKSNISQQLKKAKYGVADHSTVEICHWTKKSFRNEGSCYKHKFY
GISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLEMDEQKVAEPKDIMSKLMEERRKLIV
GHFGDPSQDKQKIEESLTPSHYAISLSGEPTMYPKLPDLIKYLKSLEATKSIFLVTNGQE
PDMIQRLADENALPTQLYLSTNASDYDSFLKINRPKYDDSWQRWNKTLEMLADLDTRTVL
RVTLIKDWNDSEEMISGFKSIFEKSNAHFIELKSYMHIGRSTNRLEYENMVEMNDVRKFS
EKIVEKSDRFEVMDESEVSRIVVLQNKKRFTERYLTAYA
>A0A2G9LJD5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Huberarchaeum crystalense|TrEMBL
MAKIKPANLKIFKRQHYSVVGNHSAVEVCSWTKKSLLNKGVCYKEKFYGIKSHRCIQMTP
AVAWCDFACLYCWRSHEYSQGTSMKGNIDDPKTIIDGAIEAQRKQLSGFKGNEKTNLKKW
QEAQNPFSFAISLNGEPTLYKKLPEFIRELRARKIISFLVSNGSHPQMLKKLYNSDSLPD
QIYISLTAINEKMHKNINCPLVKNSWKRILQTLKLIPNLKEKCRTIIRLTLIKDKNDSND
AAEKFAQLIKLANPNFIEIKSYMFLGYSRKRLKKENQCTHEQVRQFSKTLAGLCGLKVLD
EAENSKVCLIGMKKCARFDK
>A0A520KFW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MNEELLKILKSQGYQIVGKHSAVKTCHWVRKAITKGEICYKGKFYGIKTHRCLQMSPSVV
YCTNRCIYCWRILPSERGIIWNGNSLSEEDDPEFIAKESIKAHRRALTGYKGNPKVKKEV
LEEAMNPKHVAISLSGEPTLYSRISELIEEYHKMGMTTFLVTNGTRPEVLEKIKEPTQLY
ISLSAPSEEIYKKICRPVYEENWNKLIKSISLLRSFKCPTVIRITLLRNLNMEEIDDYAR
IIKIGMPKYIEVKAYMHVGCSIWRLEENSMPTHEEILLFSKKLAEKINYEIADEVQASRV
VLLKS
>A0A832D2R4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aeropyrum sp|TrEMBL
MYKARQSLVPEGIPDKWMPLVERMIKQKYHFVGRHTVVKKCYWTHRAMIDGRHCYKCKFY
GIESHRDIQMSPSAFWCWNACMHCWRIRPQDVGADIDETKMPFYDDPKILVDELIKAHRR
LMSGYKGHPKVDPKLIEEAMNPVHLTLSLTGEPTLYPLLSDLIKEVHRRGMTTFLVTRGV
RPDVLANLDEEPSQLYISIEAWDKKSYNYFTRPLVPRAWELTLETLELLPSFTSPTVIRI
TLVKGFNDHDEALRGFAKLIETAKPTYIEIKSYMWLGTSRYRLSKDSQAEHEYIREVGLK
LADYTGYPLIGESRASRVVLLSSIPEPIRLGKGCPLGLKTPEPDTIGEYDSYDPDTVP
>J3NR62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gaeumannomyces tritici (strain R3-111a-1)|TrEMBL
MLFPVPPQETTACDNETCAVALQAAMDSVLEHSLLYFDRLSSYVLDIWHGYRTPILLCAF
TCLVLIRICLYIVHGRPGEPVAFARALGTDIAKAKPNPPSLTDKAIATDEKSKPIEQPKA
KAMGPRRIRGEVNRDKTGKGAESGGPREIQPFVFFSSVTATTDKIAREYAARLEDSARAL
PPTAGCQVLAPKVLDLSEVDYDEYFITPPQLEPQQTGGRVELLYLLLLPSFNIDTINDTF
LEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCFQAKEVDRWMAKLTGRK
RACPLGVGDSKTDAAERLSEWHEGVVDVLSLLAQTGSLGEGVRGSGDAVESEDEGASEAD
DGEVLIDEDAPTTKKKAGRKAASGTLDDVEDIGRVLEASRTDGSPAAPVAIDFTTYDKTS
SSRTRKPAAQTTKEMVPKSSPTYAALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKYS
FYGINSHQCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVADAPDLIFDGIQKNHYQKIK
MMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHGERISSFLVCNAQHPD
QLAALGHVTQLYVSIDASNRESLRRVDRPLHRDFWERLQSCLEILRERRFRQRTVFRLTL
VKGFNVEDEVEGYADMVEKALPCFVEVKGVTYCGTSTSAGAGLSMANVPFYHEVCDFVTA
LEAALRRRGLAYGLAAEHAHSCCVLLASERFRVEGKWHTRIDYDRFFELLDEKGPHGDFS
PEDYMGPETPEWATWGNGGFDPRDQRVDRKGRPIEA
>A0A650CHL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfurisphaera ohwakuensis|TrEMBL
MVSNLRIDTLSLIMKELEKEKYHIVGNHSVYKKCHWTHEALTSGRYCYKGKFYGIESHRC
VQMSPTAAWCWFRCIHCWRLEPEDIGIEWDETKLPVEDDPDIIVEKSIEEHKRAVSGYFG
REGVDKNKVKEAITPRHVAISLTGEPTLYDRLGELIKEYHKRGLTTFLVTSGVRPDILAS
LEEEPTQLFVSLQAPNEFKHKLINRPIVANSWNLVMKTLEILPSFSSPTVIRMTMIKGFN
MSDEDAREFARLMEIAQPTYIEVKAYMHVGPSTYRLSKDAMPRHFEIKEFAKKLAEHTGY
KILSEHIPSRIVLLSKLDKPIQIGNAWTDNWNWATKDIEDDINGEYKEAELGCTEGET
>A0A5N5U736|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halosegnis rubeus|TrEMBL
MSDTGPKQVDDPEYHSRNHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKC
NERCVFCWRDHAGHAYELDEVEWDDPEAVVDASIELQRKLLSGFGGNDEVPRRVFDEAME
PRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLDACDPTQLYVSVDAAD
RHTFDETVAAIEDDAWERLLDTLDVLAEKDETRTVIRTTLVDGFNMHTPEWYAVMCERAD
IDFLEMKAYMYVGHSRSRLGHENMPSHEEVKAFTERVGEFLPDHDTFREVPDSRVTLLSR
DEDTWVPKLKGGSEFWS
>D3SQN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3)|TrEMBL
MSDSADAGVDVEVGGDADADSGTDDGNRDGGPAQVSSPNYHSENHTAAQTCGWTANALRG
EGRCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDDVEWDDPEAVVDASI
KLQKKLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLAAFHDRDITTFL
VSNGTRPEVLRECDPTQLYVSVDAPERHTFDQVVKAVEDDAWDRLLETMDVLRQKEETRT
VLRTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVVEFA
ESVAEYMPEFTECKGVPSSRVALLSKTSDTWVPKLKKGSEFWARDPITGD
>A0A7D9E7K5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paramuricea clavata|TrEMBL
MAAHKELNLCSFMYKFYLFILILGTAFSANGHEMNNGQYVSTLGLQDSWSVFMKNWWQTL
SVTLIAAIVACCSVVWTLKMAAKISENEEHADDIKNIHTDEKPQTTIHSVKIFFATQTGT
AQYFAGILQKRLNQELELNSKVIDLKHYDPDDSLANEINPSTLCIFILATYTDGQPTEGT
GWFYKWLRETAVDFRVQKSLLLGLNYCVLGLGNSLYEDHFNTVSSNVDKWLHDLSATRIL
PLAVSDENVAKSKNGGKEEDFNAWMDVFMTYLKTRATRENEDCCKLNSDKSTCECKNSVD
ETQVEEELYESSSEGEHDDEDGRADVMDVEDLGTMVGKMNKAKTDRIIQEPKEMITPLLR
KALTKQGYKLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMESTPSLACANKCV
FCWRHHTNPVGTEWRWKMDEPDHIVNEAINNHRNMIKQFKGL
>A0A429GIB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanodesulfokores washburnensis|TrEMBL
MRRQGYQLILNHSALKPCSWFREAIMRGRTCYKHKFFGIPSWRCIQMSPSIYCNFQCLHC
WRTNASDLPPEMRWKEIPDESYKWDDPEEIAEESIRIQRMIVQGYKGVKVFSKKMLEEAE
NPKHAAISLTGEPTLYPYIGELVEAYKRRGMTTFIVTNGSMPDVIEGLSTEPTQLYITVN
SPNRESFNRISRPLVPDAWDKVVKTLSLIKSLTSPVVMRITAIKGVNMHLAKEFAELIDK
FEPTYVEPKGYSYVGYSRRRMSRENSPSHEEVRSFAKEIANLTSYKIIDEQKESKVVLLS
KLDKPIRFY
>A0A7K4P6R4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSAETVEEDDRLLQIKPAIAKQLKKAKYGIADHATVALCHWTKKSFKHEGNCYKHKFY
GISTHGCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPKQVAEPEAILTKLMIERKELIN
GYYGDSRNDKQRLDESLLPSHYSISLSGEPTMYPKLPELIKYLHSLKATKSTFLVTNGQE
PDMIQRLQDEEALPTQLYLSTNAADYESFKRINQPKYDDSWERWNRTLAMLKHLNTRTVL
RITLIRGYNDIKEMIPAFAEMVRKASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEIKNFS
EQVAKQSKIFSIMDESFVSRISVLQNNERLIDRYIPTCVNTN
>A0A251IPB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Manihot esculenta|TrEMBL
MSLSSTPARLTLLALLSASTFYCFYKSRRLKLLKVSLNAKDNLDANPVSSSNKGKLFFIT
QTGTSKTLAQRLHNLLKLNDLPFDLIDIKDYEPEDLSKETLVIIIASTWEDGKPPSNASF
FGNWLAESADDFRVGSLLLSKCKFSVFGVGSAAYGDTFNAVAKGFSRRLRDLGANEIVEV
GEGDVDGGELDLIFEEWSGKVLRILKGGSVQNGTVFSNGCVGGESDNENIEDGFESDNDG
NGFAESGIVDLEDIAGKGPSRRSTAVAEVNEKVNGQKEMVTPVIRANLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKNWQ
WKMDDPLEIVNSAIDQHAKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINK
LVDELHQRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERF
IDSLKALKEKQQRTVYRLTLVKGWNTEDVDAYFNLFSIGQPDFIEIKGVTYCGTSATSKL
TMENVPWHSDVKAFSEALALKSKGEYEVACEHVHSCCVLLAKTEKFKVNGQWFTWIDYDK
FHDLVASGKPFNGKDYMATTPSWAVYGAQEGGFDPDQSRYRKERHHRTSH
>A0A0F8X9V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus rambellii|TrEMBL
MAESSTAEEGVLAFWHSFRLPILVALTTVIVIIRLRRKTQARRLKAATASSVPPSPRSSA
PEKTIEKHEVPAVSEKKELKGPDRTAVTGKPAPGPKRVSGRKPQKVAGRRADTTDPEPAL
TFLQPIIFYASLTGNTERYAQLFLEDLRAAAQSQSDSENRERGLLPPQMHDLAYVDFDDY
FTTAPKPPSTSPGTRYIYCFLIPSYNIDTILNTFLAHLDETHHDFRIDTGSLSTLAGFTV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTDKKRAYPLGFGDVKSDAESALKEWSRGLQ
EILGDIVEHGGLGEGVPGSGDPLESDEEDLDDEETDDAKQKARPRRKPRAVVDLEDIKMG
SNSQAGSGSPIPVDFTTSGNPAVQSIQPTEKEMVPTTSPTYAALTKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVD
SPELIFNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINGFLDL
LHSEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCL
DILREKRHIQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAG
LTMQNVPFYEEVAQFVVSLNKELERRGLDYGIAAEHAHSCCVLIASRRFHVDGKWHSRID
YPRFFELLEQEKADGTSFRPEDYMKETEEWALWGNGGFDPNDERVHKRGKKAALQRALEA
>A0A1L7V7Y4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium proliferatum (strain ET1)|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTREEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A366MH34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocorpusculum sp. MCE|TrEMBL
MSRKRSPSKTPKTSLHRQGYNFIAEGASAAVKPCLWCKRALRGGESCYKHQFYGIDTWKC
VQMTPTLRCNQRCLFCWRSMEHEILSETELSPEKIVAALPKMQKKGLSGDKPYTDPARWE
EATEHPTQYALSLSGEPTLYSKLPELIDLLREDPKNSVFVVSNGTMPSVIRRIRPTQLYL
SLDAVDVASYERICRPMGDPAAMWGNIQTSLSLLRQKEEEGSRTAVRITLVNGYNDADEA
GFAKIIEEAQPLFVEVKGYMYLGYSRMRLTEMHVHDMETIRRFAAGVAQLCNYEIMDENV
PSRVVCLKRKS
>A0A8H6UYL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus hiratsukae|TrEMBL
MMAEHSTTEGLLAFWHSYRLLFLVALSTVFVALRFYRKLQSRTKTTASSSVPPSPRSQSP
EKTEKGVSLESSNPGTTQKAEGQLTVANGPAKGTSGPKRVTGKKPSKVAGRRGQKEDAEP
LSFIQPIIFFASLTGNTERYAKILLEELRAAAQKRADLQDRERGLLPPQIHDLSYIDLDD
YFTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGSLSSLAGYS
VFGFGDKEGWHTEEEGFCSQAKELDKWMAKLTRRKRAYPLGLGDVKSDAESSLKEWSRGL
QDILFDILENGGLGEGVPGSGDPVESDEELDDEDVDKSNAQNVMDLEDIKFGGDQNSAGS
PIPVDFTTTGKSPSGQSTGKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFQGVKE
GHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGEHISSFLV
CNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHIQR
TVFRLTLVKGFNIDDEVVGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEE
VAQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKE
KADGTTFTPEDYMRETEDWALWGNGGFDPNDERVYNKGKKKNLQITAEP
>A0A520KP33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanonatronarchaeia archaeon|TrEMBL
MPPEVREILEGQGYRLVGGHSAVKLCHWLKQGLQDQPGCYKQRFYGIDSHRCLQMTPAVA
VCNQKCLFCWRSYEHWSETQLNNHDPSKELLEGVVSAQRQLLTGFKGSPEKYDLELVEEA
MNPRHLAISLSGEPTLYPELSSLIQKAHNRGMTTFLVTNGQQPRTIRDIEQPTQLYVSLD
APDKKIYNELCRPVEGGWQNLNRTLEHLPGHRGRTALRITLVKGINDNPYGYTQLIQKAK
PDFIEVKAYMHVGYSRKRLERKRMPSNDEVKAFAEKLSDKTDYSLDKHVIESRVTLLTSD
KEPQIKLERENNIE
>A0A662PWH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MNSALKEASEPMRGELAKLRKAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGIRSHR
CLQMTPSLQYCNMMCLFCWRHHTINRVEGPAEDWDEPEEILDGLIKEQRQLLSGFKGNPI
VDRRLFEEAMEPKHMAISLDGEPTLYPYLGDLIKLARNKGMTTFLVTNGTNPARLRELIE
ENAEPTNLYVSFYGPDPETHRRICRPLIDDSWERLVKSLRLMGEYRKSRRVIRLIMIRGH
TIHSPEKYAEMIKMAEPDFVECKGYMHVGESQRRLRRDAMPSMDEIRIFARKLASLLGYE
YLAEDHASRVSLLANPSSSRYEEVRSRVSRLSSFENAP
>A0A533V6T8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEYISHTDTQNLIQISPLTKAKLKKAKYGVYNHSAVELCHWTKKSFSNEGTCYKHK
FYGISTHRCMEMTPTAMNCENRCIYCWRPTEFYDTLKMPENLVDEPDMIINNLVEERRKL
IVGHYGNTKSDKIKLDESLFPQHYAISLSGEPTMYPKLPSLIKYLKTLENTKSIFLVTNG
QEPEMLQRLIDEEALPTQLYLSTNASNKKMFTLVNRPRYTDAWDRWQKSLELLSQMDTRT
VLRMTMIRNINNSNNYIEEFADLMRRANPHFIEIKSYMHIGMSTQRLENSDMLEMDEIRS
YSHLLCQYLDTFSLMDESEISRIVVLQNLKRYTERWIEGYEKPITQ
>A0A2V2UF26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEHVSHVTQDNLIQISPAVKSRLQKAKYGVYNHSAVELCHWTKKSFSNAGNCYKHK
FYGISTHRCMEMTPTAMNCENRCVYCWRPTEFYDTLQMPPELVDEPDVIVEHLLAERKKL
INGFYGHEKNDKKKLDESLFPAHYAISLSGEPTMYPKLPQLIKYLGRLPATKSIFLVTNG
QEPEMLQRLADEDSLPTQIYLSTNASNKKMFYLVNRPRHRDAWERWRNSLRFLSTADTRT
VLRMTIIRQYNDAMNFVDEFAEMMQQGNPHFIELKSYMHIGMSTQRLEAENMLEMKEIRS
FSEQMCFKLQGYSIMDESEISRIVVLQNMRRYTDRWIKEYPIEA
>A0A2P5AWG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Parasponia andersonii|TrEMBL
MYLTSVQARLTVLALLSATTFYCLYKSRRLRNLRISLNPNPKPSSSSSSSSSRNGKLFFI
SQTGTSKALARRLLDLLTSNNLAFDLVDAKDFEPEDLPKETLVLIIASTWEDGKAPPDAR
FFTDWLAESAEDFRVGSLLLSKCKFAVFGVGSRAYGATFNAVARDLSKRMRGLGGDEMLP
VWEGDVDGGDVDGLFDAWGGKLVKLLKGDGVEDGVVLANGVSAESDAESEEESDDEEYIP
ESEIVDLEDIAGKGPSRRSAAVSKTNGINGTSNGKKDMVTPVIRASLEKQGYKIIGSHSG
VKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQW
KMDDPLEIVNSAIDQHTKMIKQMKGVPGVTLERLMEGLSPRHCALSLVGEPIMYPEINAL
VDELHRRRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFL
DSLKALRDKQQRTVYRLTLVKGWNTKEVDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLT
MENVPWHADVKAFSEALALRSEGEYEVACEHAHSCCVLLAKTDKFKINGQWFTWIDYEKF
HDLVASGRPFDSKDYMAATPSWAVFGAEEGGFDPDQLRYKKERHHNRSSQVPARPG
>A0A663ENW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aquila chrysaetos chrysaetos|TrEMBL
MDTWNFYTCLVSLWLHRLYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASFEGIED
KVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDYDPDD
CLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFGLG
NSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRL
QALCRGEKKPCSGKCKKGKCKSPGKQSKDCSDHEHGASEYENTEAEELFETSSDEEADGE
EAGGTNSVIDVEDLGSIMSHMKKAKRERELEEGDTGTSLTHKNAGRKEEGEKREMITPAL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKFKINGEWWTWIDYDRFQELVREHERSSRSKTFTAADYAARTPCWALFGSRERGFDPL
DVRYQRKNKARDISGC
>A0A498JCU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Malus domestica|TrEMBL
MAVAVARLARLGRKAKLPGGFCIKMAAAAILGLCFIFAWSMFSSPSSSVTTRIESFDNIV
APPGSRSTRASTPDGTQQAASNGGEEKRATGSAVRSPVHEHKSEKKEKKVVNGKKGKGKK
KLPESVTKVKNVTEESESEDSENEKEDGDEEKEVVDGKEEALSDEGEGNGEAGGEGGNLM
ETADQESEEVKLDDDGGESEKKGKKRYKMKGPLFDPKAHYSWKQCSTRSKHNYIPCIDME
VVSGRLQYRHTERSCPKAEPMCLVPLPRDGYGLPVPWPESKEKILYKNVEHPKLAAFVKE
HSWVMESGEYLTFPQNQSELKGGILHYLESIEEMVPDIEWGKNIRVVLDIGCTDSAFGAS
LVDKDVLTLALGLKDDLVDLAQVALECGLPAFVSPFRNRRLPFPSSVFDAVHCGGCTIPW
HSNGGKHLLEMNRILRPGGYFVLSTKHDSFEDEEAMTKLTASICWNILAHKTDEVSDVGV
KIYQKPDSNDIYELRRKKYPPLCKENENPDAAWYVPVKTCLHPIPSAIEQHGTEWPDEWP
QRLERYPDWLSDKVNLDADTKHWKAIVDRSYLTGLGIDWSKIRNVMDMKAIYGGFAAALT
QQKVWVMNVVPVHAPDTLPFIFERGLVGTYHDWCESFGTYPRSYDLLHVDHLFSRLKNRC
KQPVSIVVEMDRLLRPGGWAIIREKVEVLEPLEGILKSMHWEIRMTFAQGKEGILCAQKT
FSSPRRGKLFFVSQTGTSEALARRLLDVLTSNGVAFDLVDPSNYEPEDLPKETLVLIVAS
TWDDGKPPPNARFFSNWLAESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDLAR
RMRALGASEMFPIWEGDVDGGDLDEVFDAWSGKVVRFLKGGAAENGGVLGNGVGDECEAE
SFDGSDEDEEDEEEDGEESGVVDLEDIAGKGPSRRNPVAVTKTNGTVNGKKEMVTPVIRA
SLTKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGKSWQWKMDDPLEIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLSPRHCAL
SLVGEPIMYPEINSLVDELHRRRISTFLVTNAQFPEKIKMLNPITQLYVSVDAATKESLK
AIDRPLFGDFWERFIDSLTSLKDKQQRTVYRLTLVKGWNTEDIDAYYNIFSLGSPDFVEI
KGVTYCGTSATSKLTMENVPWHADVKTFSEALALKSNGEYEVACEHVHSCCVLLAKTSKF
KINGQWFTWIDYEKFHDLVASGKPFDSKDYMAPTPSWAVYGADEGGFDPYQSRYKKERHH
RPNQ
>A0A6A9SVC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halapricum sp. CBA1109|TrEMBL
MSESDGPKQVDDPDYHSVNHTAVQTCGWTDNALQGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPEAVVDASIDLQRKLLSGYGGNDNVPEDVLEQAM
EPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTNPEMLERCDPTQLYVSVDAA
DRKTFDETVKGVEDGLWDSLIETLDVLAEKDDTRTVIRTTLVGDHNMHHPEWYAAMCDRA
DADFVELKAYMHVGHSRGRLDRSSMPDHEDVLAFAESMREYLPHDHVKDIPDSRVAMLSE
GPDTWVPKLDKGSEFWTEDPLADV
>A0A495R0F9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula quadrata|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A6V8EP68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPKIAARLAKQSYHLVGDHGGVKVCHWTKQSLVADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDSLTKIDDDPYELFLQSVKAHRRLLTGFGGHPSVPREKWLDAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIENLDTLPTQLYVSVDAP
NKEIFDRICKPKFDQSAFEKLEQTLELLPSLDTRTVCRHTLIKGESLGHWKDYARLDNIA
DPDFIEAKGYIYVGNSQSNHTIENMPSHDEVMEFSRNLAPLVGREVLSDRRESRVALIGK
EMVPVTLPTKIRDLPKDLGIAKPQKFSLPQL
>A0A822XBI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPRIAAKLAKQRYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIESLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGHHEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSQELAPLVDREVLSERRESRVALIGR
EMIPVKLPEKIRDLPKDLGIAKPQNLSLPTL
>M0BSI0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halovivax asiaticus JCM 14624|TrEMBL
MSNADAAGSGGEADPDTGDGGPKQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIFY
GIESHRCIQMTPVVRCNERCVFCWRDHQGHAYELDDVEWDDPEAVVDASLTLQRKLLSGF
GGNDEVPREAFDEAMEPRHVAISLDGEPSLYPYLPELIDAFHDRDITTFLVSNGTRPEVL
AECDPTQLYVSVDAPERHTFDQVVRAMEDDAWETLVETLDVLAEKDETRTVLRTTLLQGE
NMHSPDWYAGLFQRADPDFVELKAYMHVGHSQGRLDRSTMPDHEDVVDFAERIGEHMPEH
PVLKEVPASRVALLARSEDTWVPKLQKDSAFWERDPIVGE
>G7MP27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca mulatta|TrEMBL
LDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A7L4JBB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pomatorhinus ruficollis|TrEMBL
LDVSMDTWSSFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTITRTKRKVTEPGTADKLG
NGCATPQAQEVHVAGVKIFYGSQTGTGKRFARTLAEAVTSLNLPVEVINMGDYDPEDGLV
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTRSKHGSIEADFEAWKTKFLTRLQVL
CKGEKKPCSGKCKKGKCKSSGKHSKESSDHEHGTSEHENTEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGHVKKAKVLLLRGYGMVSHFGYHLVYLVCQFLQTKLNFLMICALFSGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMY
PHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGES
SASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKVSLTGHTC
>A0A093HK28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Struthio camelus australis|TrEMBL
LDVSMDTLNFFYACLMSLWLHRFYIYSSVTLGISIWICIQFFTSKTRKKVEKFNGNPASA
EVTEGKLVNGYATLKAEEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPAEVINMGD
YDPDDNLVEETSSRNVCVFLVATYTDGQPTENAAWFCKWLEETVNDFRFGKMYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSMEADFEAWKTK
FLSRLQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDHEHGASEYENTEAEEFFETTSEE
ESNAEEAGGTNSVIDVEDLGKIMSHMKKAKKKRELEEGGGRTSLSQESAGRKEEGERREM
ITEALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLI
AHKKVRL
>A0A6P3EQY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ovis aries|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNLQEKTTPKASQD
LMTNGYVFRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLDLPVAVINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGERKRCRGNCKKGKCESNQRSSEAMEPGSRAQEELHHGDAEEEEPFGSTSEEESD
TEDHQSQNSVIDVEDLGKMMDHVKKEKREKELQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKGERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGGEWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>A0A086M5H7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii RUB|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFL
>A0A6G1EW69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza meyeriana var. granulata|TrEMBL
MSPFPTATASASASTTSHLALLLLSSSSIFFLYKSLRLRRLRRNPSPPSPGPDPTPTPTL
LYASATGTSKALAASLSRRLAEAGVTAHPTDAAGFDPDDLPSVPLLLLVLPTHDGGAPPP
AAAFLARWLEESTADFRAGAALLSHLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVE
VVSIGEGDVDGGDLDVAFEEWCGRVLRMVKGEEIEEKPKGESDGFDELELGGEESDDDEE
EEVDGGEVDMEDIAGKAPARRQNGKVEGALPNGGENGVREMVTPIIRTSLEKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WKWKIDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEI
NVLVDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWE
RFLDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSTTS
KLTMENVPWHSDVKEFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKISGKWHTWIDY
DQFHELVTSGKPFKSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHAAAAHKD
>A0A7C3R4X9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MSMKKIRIPERIARMLKKAHYGIFGHSTVEICHWTKKVLKGEGVCYKRKFFGIETHRCMQ
FSPAGIYCENRCIYCWRPCEFYFVKKMDESKVDDPKEIVENLIKERKQLLSGFGGNEKVI
KELFKEALIPSHFAISLSGEPTLYPKLPELIKYLKSLEFTKSIFLVTNGQEPKMLERLRK
EKALPTQLYLSLNAGSKKMFEKINRPLLKDAWQRFQKSLKFISKVTTRTVIRFTLIKGFN
DGEEELKSITKLMKKGNPHFIEIKAYMHLGYSTKRLKSQNMPKHFEVKEFAFKLLNELKN
FEYMDEDFDSRIVILKNKRRKVKRWILYPEESTLFKYNL
>W6MPN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kuraishia capsulata CBS 1993|TrEMBL
MAGSTIAVGAGCAVLYLLNGGRWSVTLLILLAFIFISSSQSEVSSESHKTNETGKPKSPP
QPDELAMDFTTVDFAAKTKPTFRKAPDATKVVTEGAVSLKKSAKRVPKVIKATRPVRKSA
KEILTKSHETLVNSNIIIFYTSLTGASERTARRLYEHITSLGLTNKPQILNLDEDVDDLD
DYFVNVPKKDQLVYILVLPSYETDSPIDYFLDTLQETANDFRVDKYPLKKLAGFAVLGLG
DSESWPEKFCYQAQIADKRLSALGGRRIFPVGTVCIKTGGELKVDEWIRGLGESITDDEP
FVFQEMESDDEDEDSNASSEDTLIDVEDITKGFNVASSDEKIEIKQMVAKDSPTYKSLTK
QGYTVVGSHSGVKICRWTKSALRGRGSCYKFAFYGIRSHLCMETTPSLSCSNKCVFCWRH
GTNPVGTTWRWQVDEPDVILKGALEGHYKKIKQMRGVPGVDSDRFNEAFTVRHCALSLVG
EPIFYPHINEFVGMLHAKHISSFLVCNAQHPDQLKALNKVTQLYVSIDAANKNELKRVDR
PLYKDYWDRLQKCLEILSTTQLHQRTVFRLTLVKGFNMGEVEGYADMVEKGLPSLIEIKG
ATFCGSSSGNGNPLTMQNIPFYEECQNFVRALNKEVNSRGLEYDIAAEHAHSCCILIAQK
KFQREGKWYTHIDYKRFFELLESGEEFTDMDYIAPTPEWAYWGSEQAGFNPQDQRFNRKE
EKLKRKLAMEV
>A0A0E3LPG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina barkeri MS|TrEMBL
MRKMPLEENKENAGENFPEAQNKNRKEDTASLPFDIPDFKTLLKKQGYALAGRHSAVKTC
LWLRHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPE
KIVEESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIKEYEK
RGFTTFLVTNGTVPEMFAKVSPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSLMK
QKKSRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSQELAKHLGYEVADESEISRVVLLSKDGRKSPVNGKKISC
>A0A2I0M1P6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Columba livia|TrEMBL
MGDYDPDDCLAEEVTGXXXFLVATYTDGQPTESAAWFCKWLQEAAHDFRFGKTHLKGLRY
AVFGLGNSVYVDHYNTVGRNIDRWLWMLGASRIMTRVEGDCNVAQSKHGSIEADFEAWRT
KFLNRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDPEHGASEYENTEAEELFETSSE
EEADAEEAGGTNSVIDVEDLGNIMSHMKKAKRDCELEDGDVGKNLAQENSGRKEESERRE
MITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHCCMEATPSL
ACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEALENHRNMIKQFKGVSGVRADRLAEA
MTAKHCALSLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVD
ASTKESLKRIDRPLFRDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISL
GKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQDLADLVPDYEIACEHQHSNCLL
IAHKKFKVDGDWFTWIDYGRFQELVREHERSGGAETFTAADYAARTPEWALFGSRERGFD
PLDVRYQRKNKARDISGC
>A0A6A6HP05|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Viridothelium virens|TrEMBL
MDSWNLPQELLVIWHTYRLPIVLSLIGLIALFQLFRHWSNTRTAHVHLEGHLPSVSRGSK
EADTSQEELIEGKLGSYEVAVEKAVRPLEDVESNVRPKSVGPRRITGSKKGAASLKTHHE
EDLAPVQPLIFYSSLGGTTEKAAISLQDNFLDSISKSSSLHQSLNILKPVAHDLSYIDYD
DFFITAPKDAKFRYFYMLLLPTYNIDTQLDNFLEHLKETHHDFRIDTGPLSSILGYSVFG
FGDKDGWPTEEEGFCSQAKEVDKWLAKLTNRKRAFPLGTGDVKSDAPEQLGRWRLGVEEV
LKDLAQGRGLGEGVPGSGDPMESDEEDVQDESQNATSQRKRRRKPATSSDLEDINVPKAD
TGSGPIAIDFTHYSQRPTSSTPPSPLKEMVPASSPTHAALTKQGYTIIGSHSGVKICRWT
KSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTIWRWATDPPDL
ILAGAKAAHYAKIRALRGVPGVRADRFVDATTRIRHCALSLVGEPIFYPRINELLKLLHA
ERVSTFLVCNAQHPEQLASLAKVTQLYVSIDASNKESLRRVDRPLHRDFWERFCRCLDIL
RERRLEQRTVFRLTLVKGFNLDEEAAGYAALVERARPAFVEVKGVTYCGTSVSAGAGLTM
QNVPFYHEVRAFVAKLAEELRGRHGLGYGIAAEHAHSCCVLLGDETRFRKGGKWRTWIDY
GRFFELLESGEEFGPEDYVGKETPAWALDGRGGFDPRDERVDRKGRRIEESKENAQVKVT
EVAT
>A0A2H9NHP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon CG_4_8_14_3_um_filter_37_24|TrEMBL
MDENLKKLLEKQQYRFSGNHSVVKICRWTKKSLVEGKVCYKEKWYPPVKSHRCMQMSPSL
VCNHRCLFCWRLHSGDRGFSWKESFEGLVLDEPKDILEKCIEQRKSLLTGFKGFERVDKR
KWEEALKPNMMAISLTGEPTMYPKLDELIQEAKRMNIISFLVTNGTLPDRLQSLNTKPFQ
LYVTLPAPNKETYKKLCQPSTPKLWDKIMETLELIDSFDCRKVIRLTLVKGLNMVEPEEY
AKLIEKANPDFVEAKGYVHVGESQKRLPMDAMPYHEDIIEFSKEIEKHSSFRIKDVFKPS
RVVLLKK
>G2WNX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain Kyokai no. 7 / NBRC 101557)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFKKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDISAYADLVQRG
LPSFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVNFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A7K5E5N0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Polioptila caerulea|TrEMBL
LDVSMDTWSYFHTCMVSVWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKFRGNPSSHEG
TAYKLGNGCASPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDCD
PEDALAEETSSRNIYVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKGFLQGLRYAVF
GLGNSAYVDHYNTVGRRIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGKKKPCSGKCKKGKCKSSGKQSMESSDHEHGTSEHENTEAEELFEMSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKRELELQEGAAGAGWKEEAERREMITPALREALTKQGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVAGVKAARLEEALAVKHCALSLVGEPI
MYPQINRFVRLLHQHGISTFLVTNAQFPEEIRKLEPVTQLYVSVDASTKESLRRIDRPLF
KDFWQRFLDCLKALAEKQQRTVYRLTLVKAWNVDELKTYADLISLGKPDFIEVKGVTYCG
ESSASSLTMANVPWHGEVVSFVQELVRLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTW
IDYSRFQELVREYEQSGGSRTFTAAEYTARTPPWALFGAREQGFDPSDVRFQRKNKARDT
SGC
>A0A483CRF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofollis fontis|TrEMBL
MRSQRCEGARGALKKQGYQFFSPESTAAVKPCMWNKRSLKGGEMCYKNRFYGITSHRCVQ
MTPTLRCNQRCRFCWRSFEHEVEEVEECPPEVILENVRRLQKRALSGYKVSRYVSKERFA
EALDPDMVAVSLSGEPTLYSRLAELIDGFNAEGFTTFLVTNGTRPEMLARCRPFQTYVSV
DAPDRGTYLDLCNPDEDYWDRIMESLDLLSSRRSAIRTTVVKGLNDIDAAGYAAIYERSR
PTYIEVKGYMYLGYSRKRLERENMPDHAEVRAFAEEIAAHCSYEITDESPISRVVLMERR
GDE
>A0A2J5HFM1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus taichungensis|TrEMBL
MAQESLVEGLLTLWHAYRVPILVILLTALLVSRTIGITGSKAKAASAFSNPTSPRSHSPE
KSEKPQLDDARDRPAPAADAPKTAAAGPKRVTGKKPAKVAGRRAGAEPAPQLSAIQPIVF
FASLTGTTEKYAKLLMEELTAAAKDQADGENPERGLLAPQLQDISYVDFDDFFTTAPKPP
PNSPGTRYLYCLLIPTYNIDTVLTTFLGHLDETHNDFRIDTGSLSTLAGYSVFGFGDKEG
WPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDGEAALKEWSRGLQDIMRDILD
YGGLGEGVPGSGDALESDEEDLDDEESGESNKKGRKRGKPQAVVDLEDIKMSVGGDSGSA
APIPVDFTTGGQSAAPAQSTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFDGV
KDGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINGFLDLLHAEHISSF
LVCNAQHPDQLETLHRVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILREKRHV
QRTVFRLTLVKGFNVDDEVNGYADLVEKALPCFVEVKGVTYCGTSSSAGAGLTMKNVPFY
EEIAEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASERFHVDGKWHSRIDYGRFFELLE
KEQADGTSFRPEDYMRETEEWALWGNGGFDPNDERFYRKGKKKVIEPAATEAATEF
>A0A3D8R6C0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coleophoma cylindrospora|TrEMBL
MPQNTWAQELLWPVDRIDLVAVWHTYRIPIILSTFTILCIFRAYLHLSVPRNKVSFTPPP
SSPILSSTKSKAPVNDVVEVRTVAEKSSAVQKAPRRIVGGLKKRKSSEEQLTTNDHQIQV
LIFFSTLTGTTERAAKTLGQELRNRTGRFLEPQVLDLAELDYDDYFISPPKSETDVQYFY
LLLLPTFDIDTILDTFLEQLQETHNDFRIDTAPLSGLLGFSVFGFGDREGWPTEETGFCS
QAKDVDRWMAKLTGRKRAYPLGMGDAKKDAASRLSDWKQGVEDVLDLIAETGGLGEGVVG
SGDAVESDVEDEEEDDGEVVFDDENVALPKSKAKKDSVNDVEDLGKGLRTDASPSEAAEP
SDTFEVDFTTYSKKSKPPPAPPVIKEMVPKSSPTYTALTKQGYTVVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDAPDMIF
NGVKAGHYQKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPISYPYINEFTSMLHAEHI
SSFLVCNAQHPDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILRER
RFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEIKGVTYCGTSSSAGAGLTMQNV
PFYEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILIASDRFRVDGKWHTRIDYEAFFR
CLESGKPFTPEDYMGPETPEWATWGKGGFDPRDERVHRKGKNKKPLPESKVEELF
>A0A0L0P6U0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida auris|TrEMBL
MTSGTPILAICSLIYWLTGGRITFVAAAWCALWFHKGKLQPFSAASSAPPITKPVKSSRI
MEVDFTNSFTPDSKTEFPKAVPLKKKTRRTREPKIFKAAAKLGKPSKGVSHLTTNLVQLK
KCPIYIFYTTLTGLSLRVAKALHQKMANIDGIEVPPRLLSLDDDVDDLEEYFLRTPKSEN
PPVYLLVLPSYETDSPIDYFLEHLTDTYQDFRVDKYPLRTLAGFAVLGLGDSESWPGSQF
CYQAKSADKWLGKLGARRLFPVGEVCMKHEGEPKSQDWINGFLELMVDDQPFFFEDDPAA
FDSDAGSDEEEAQAEDENVVDVEDMGAIIRASKNKDAAVAEPKQMVAQDSPTYKSLTKQG
YTIVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGT
NPVAKLNWRWEVDPPEKVLEGALDGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGE
PIFYPHINEFVGMLHSRHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKNDLKKVDRP
LNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGA
TFCGSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTK
FKINNVWHTHIDYPKFFELLESGADFCDLDYIQKTPDWAIWGAEEGGFNPADTRYDRKAE
KLKKKQARDEAAAKALQAKKSESIKASSEFSEHTRELFVS
>A8M8X9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)|TrEMBL
MENSEVKVKLRYHEFIEGKVRISVDALPMLKNAHYGVYGHATVELCHWTKSALTGGPSCY
KVKFYGAPVGGSHRCVEMGPVGMMCSNKCVYCWRPSESFDPYEPMSLEVMDPVDMVNGIL
KERRRLLSGYFGHAKSSRDKVNEALQPTHWAISLSGEPTMYPRLPELIKYIKSLPSTKSV
FLVTNGLYPEMIEKLWREDALPTQLYLSLNAPNKELFLKIANPVVHRDDAWERVLRSLEL
LAKIPTRTVVRITLIKGWNTGSELLGQFAEVLGIGNPHFIEPKSYMHLGHSVYKLSKLNM
LRHEEVKEWSLSLLKALESRGLRYIFMDEDPNSRITVLQNMNRYVDRWIEKPSSEANP
>A0A376B486|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomycodes ludwigii|TrEMBL
MLKLILEYLLCILSISLYLIHGGRVTIALAVIVGFNVYEYEKYQSKKNSNPPLVSKEEKP
ITKKKTCCGGKGGASCCSKNNKSNGKKCACSGGGGNCGKSKTVGSQGDEKKTTSSNVANN
SNSVEEIDFTNAFKKVSSKKNTTKKSPASSKNVKVSAKKNIPKSGLTVSNNLLDSQIYIL
YSTLQGAGERAANTVKERLGFLYPNDLKKEPIIVHLDEVNDLEDYFVNVPKNSIYIMVVP
SYDTDSPLDYSLETLDEISNDFRIDKYPLQKLVGFSVLGLGDSESWPEKFCYQAKQLDQL
LSTIGGRRIFPMGQICMKRDKWGAVEEWADLLGETLKDNEPILYEYDEDEQETSEPVVDL
EDIGKSEELDTTTKKMVSENSPTYKNLTKQGYTVIGSHSGVKICRWTKNDLRGRGSCYKH
SLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEIDEPEYILEEGLKGHYSKI
KQMRGVPGVRADRFQKAFQVRHCALSLVGEPIMYPHINKFVELLHEKDISSFLVCNAQHP
SQLKAMRKVTQLYLSIDAPTKSELKKVDRPLYKDFWERMMECLDIIRTTQSHQRTVLRLT
LVKGFNMADVSSYADIVEKGLPCFIEVKGATFCGSSDGNGNPLTMQNIPYYEECVKFVES
LTEELNRRGLEYGVAAEHAHSNCILIASRKFYIDGEWYTHIDFDKFFELLRSDVPFTNVD
YIAKTPEWALFGSGGFAPDNVRFYRKKKDRNDDTKEQKQENVA
>A0A2G5EA93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aquilegia coerulea|TrEMBL
MAIARLARLSRQVKRPHGFCIKMTAVAALGLCVIFILSTYSPSSSSLTSQRNSFSDIAEP
VAANEKSKKGKDFDMQHKMSSNHGNEVGKKKLEPHLKDKDKKKGDGAVSVNNRNSGKKNK
KKARKPKTEEIDLKQHEVIGLNATQMQEGVEGEELEEEKEGDEELKEDAEEIVDNDAVNN
DGEVEEDRDLNATDGEETVEKTEDEDAGLKSTERKKKKLGPVFDLQAHYSWKTCSVRSKH
NYIPCLDMESTSGKLQSYRHHERSCPKTPPMCLVTLPPEGYGSPVQWPESKFKILYRNVE
HPKLASFIKTKTWLMQSEEYLTFPQNQSEFNGGVHHYIDAIEEMVPDIEWGKNIHIVLDI
GCTDSSFAASLLDKEVLTLTLGLKEDLVDLAQVALERGFGAIVSPFRTRRLPFPSDVFDT
IHCGGCNIPWHSNGGNLLLEMNRVLRPGGYFILSTKHDNIEDEEAMSTLMASICWNILAH
KTDEISEMGVKIYQKPDTNDIYELRRKKNPPLCKEDENPDATWSVPIKACLHGIPSAIEQ
RGTEWPAEWPQRLQTFPEWMSNRENLVADTEHWKSIVEKSYLIGMGINWSNVRNIMDMKA
MYGGFAAALVPHNVWVMNVVPVHAPNTLPVIYERGLVGVYHDWCESFGTYPRTYDLLHAD
HLFSRLKNRCKQPVGIVVEMDRILRPGGWAIIRDKVEILDPLEVILRSLHWEIRMTYAKD
KEGKLLFVSQTGTSKTLANRLYNLLNLNNLSFDLIDSKDYEPEDFPKETLVLIIASTWEN
GKPPECSKFFANWLAESAEDFRVGSLILSKCKFAVFGVGSKSYGESFNAVGKEFAVRLKE
LGGDEVLNLGEGDVDGGDLDEVFDVWSRKLVRVLKGEVEENGGAYGNGVVVSESEYDSYV
ESDEEDFEEKGLDSGMVDLEDIAGKGPSRKSSSVFTEVKKVANGVKEMVTPVIRASLQKQ
GYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
SNPVGKSWQWKMDDPLVIVNAAIDEHTKMIKQMKGVPGVKSEILLEGLSPRHCALSLVGE
PIMYPEINTLIDELHRRRISTFLVTNAQFPEKIRMLKPITQLYVSVDAATKESLKAIDRP
LFGDFWERFLVSTLSVSSITENIAEVRIIRTFFRFTEEVRGFFTSCVKSCLSSGTFKL
>A0A1L9SD13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicilliopsis zonata CBS 506.65|TrEMBL
MADASVPTAAQGLLSVWHTYRIPVLFLSAVILAVHASRKSQPRLKTPDSSSVPSSPPPSS
PVITEKPVEKRIEKKPAVKTNGPKRVQGKKPARSSGAGQAVESLTCIQPIIFYASLTGST
ERYAQILLEDLRAAAQTLSDGEDSDRGLLAPQIHDLAYVDFDDYFTSAPKPPATAPGTRY
VYCLLLPSYNIDTVINTFLSHLDETHNDFRIDTGSLSTLAGYTVFGFGDKENWPTEEEGF
CSQATELDRWMAKLSGRKRAYPLGFGDVKSDAHDALREWSAGLQQTLGEMLKYGGLGEGI
PGSGDALESDEEGEEEDDDGDENEAPAKNRKRNKGTVVDVEDIQMGDSSSPLPIDFTTVG
QSGVTTTTTTATAKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWQVDSPELIFDGIKEGHYKKI
KMMRGIPGVRAERFAEALRIRHCALSLVGEPIFYPHINRFLDLLHGDRISSFLVCNAQHP
DQLQTLQRVTQLYVSIDASNREALRRIDRPLHRDFWERFQRCLDILREKRHVQRTVFRLT
LVKGFNVDEEVSGYADLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEEVAQFVE
ALHAELQRRGLGYGIAAEHAHSCCVLLASDRFHVDGKWHTRINYDRFFDLLEREKSLGTP
FTPEDYMRETEEWAYWGKGGFDPNDERVYRKKKAKAEQ
>A0A446UNZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRTLRPSPSPSSSPAAAAAAP
TLLYASATGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDD
DDEEEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLEKQ
GYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGE
PIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRP
LFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTY
CGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGK
WHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAAL
KG
>A0A6V8QLP4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma asperellum|TrEMBL
MDAGSRLQLGTAVADLMDLWHTYRTSIILCALVLLVGLRTLLHSTEEREPLAVLPQIYNQ
EKPEAKEKIALKAQPVAAAEKKSTGPRRIKGGVARKPSQEKKTTAIDYTDRPAKILVFFS
SVTTKTEKIAHEYIKTLETFLDQKAGETESKFLKPELLDLTEIDFEDYFVSPPKSAENAA
FVYLFLLPSYNIDSINDTFLQHLQETHHDFRIDTAPLSPLIGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFTEWATGVQDVISQAVQTGFLGEG
VPGSGDAVESDEEDAEADDGEVVFDDDEESGDSKSSDGSRPLDDVEDLGKMIRPNKDGNE
TTRKAPLAVDFTTYPSAGKRKAQAPIVKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRW
TKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPD
MIFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHN
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFLRCLDIL
REKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTATSSNAGLSM
SNVPFYWEVCEFVKALDKRLQEKGLDYGIAAEHAHSCCVLLASKRFNVNGKWHTHIDYQR
FFELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVTREAPE
>A0A446TGG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSIALRRLRRTLRPSPSPSSSSPAAAAXX
XXXXXXATGTSKALAERLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEDDAVDGETNGFDGLEGEESDYDD
DDDEEEEEEVASGEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQ
GYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGE
PIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRP
LFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTY
CGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGK
WHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAAL
KG
>A0A164WE90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daucus carota subsp. sativus|TrEMBL
MSPPSTLTITTHLTLLTLLTAATSYLFYKSRRLKLLKLQSLNPNFSPRKPKLIYVSQTGT
CKTLAHRLHALLASSNLLFDLVDSKDYEPEELHKESVVLVVVSTWENGSAPSSGRFLADW
LSESVSDFRVGNLLLSGVKFAVFGVGSRMYDETYNVVGREFSKGMRALGGAEVLGFCEGD
VDGELDEVFDAWSRDVVGVLKGGVEGNGGFVCDASDDEVVDEDEDDYDEEEDVEGGEEGI
VDLEDLAGRGPSRNFVVEVKKVNGKVNGEKEMVTPVIRASLVKQGYKIIGSHSGVKLCRW
TKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPL
DIVNTAIDLHTKMIKQMKGVPGVKAERLLEGLSPRHCALSLVGEPIMYPEINSLVDELHQ
RRISTFLVTNAQFPEKIKALRPITQLYVSVDAATKESLKAVDRPLFGDFWERFLDSLKSL
REKKQRTVYRLTLVKGWNTEEIDAYYSLFDVGDPDFIEIKGVTYCGSSATSKLTMENVPW
HADVKSFSEALAEKSKGVYEVACEHVHSCCVLLAKVDKFKINGQWYTWIDYEKFHDLVAA
GKPFDSKDYMAPTPSWAAYGAEEGGFDPKQIRFKKERHHKAK
>A0A7K5DP28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pachyramphus minor|TrEMBL
LDVSMDTWSYFHTCLASIWLHRFYIYSAVALGISLWIVIQFTTTKKKGEKSSGNPTSSKG
TEDKLVNGCATPQAKEVYVAAVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRVGKTYLKGLRYAVF
GLGNSVYVDHYNTVGRRLDRWLWVLGASRVMTRAEGDCNVAQSRHGSIEGDFEAWKNKFL
TRLQALCRGEKKPCSGKCKKGKCRSPGKPSKESSDHEHGASEHENTEAEELFETSSEEEA
DAEEAGGTNSVIDVEDLGNIMGHVKKAKSSIDTVLLNHFGYPLVCFMSQLLQAKISSSLF
FALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFRGVSGVKAARFEEALTVKHCAL
SLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTRESLR
RIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVGFVQDLAELLPDYEIACEHEHSNCLLLAHTKFKV
DGEWFTWIDYGRFQQLVRERERSGGSRTFTAADYTARTPPWALFGARERGFDPLDVRFQR
RNKARDISGC
>C5M8U5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida tropicalis (strain ATCC MYA-3404 / T1)|TrEMBL
MGSGSILLGACSILYLISGGRWTVVLLGVVLTILYKVEKSNNKVVASPHQKEEIITKKPT
KESPIYAVDFTSTSFTPSATTVIPKQTVRSRAKRSPKIIKATKPRSLDQQTPQKQQSVLT
KSSIELSKSQIYIFYTTLTGSSQRIAKSLYEKLTGLELDKEPKLLSLDDDVDDLEEYFLK
VPEENAIYLLVLPSYETDSPIDYFLEHLIDTFQDFRVDKYPLRKINGFSVLGLGDSESWS
GEKFCYQSKLADKWLGKLGARRLYPLGQVCMKYQGEPKAQEWIQNFASMLDNDEPFYIDE
NDDIDDSDAEEEGSDDADTLVDVEDMGDIIRKSGKSVETKEMVAKDSPTFKSLTKQGYTV
VGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPV
AKSNWRWEVDPPEKVMAGALEGHYKKIKQMRGVPGIQMDRFEEAFQVRHCALSLVGEPIF
YPHINEFVGMLHKQHISSFLVCNAQHPDALARLAKVTQLYVSIDAPTKKDLKKVDRPLNS
DFWERLMSCLDILRTTQSHQRTVFRLTLVKGFNMNDIESYADMVERARPSQIEIKGATFC
GSSNGNGNPLTMQNIPFYEECKTFVENLTSELQNRGLDYDIAAEHAHSCCILVADKKFMI
NGKWHTHIDYPKFFKLLESGEDFVDLDYIKETPEWAVWGSDGAGFNPADTKYDRKAEKLK
KKIAREEQAKLALEQQKESL
>Q4J964|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)|TrEMBL
MEGQLKIDTFSVIMKELEKEKYHVVGSHSVYKKCHWTHEALTTGRYCYKGKFYGIESHRC
VQMSPSAAWCWFRCIHCWRLEPEDIGIEWDETKIPIEDEPEIIVERSIEEHKRAVSGYFG
RNGVPKNKVIDAATPRHVAISLTGEPTLYNRIGELIKEYHRKGLTTFLVTSGVRPDILAS
LEEEPTQLFVSIQAPNYKKHKIMNRPIVPNSWELFLETLKILPSFSSPTVIRMTMIKGYN
MSEEDAKDFAKLIELSQPTYIEVKSYMHVGPSTYRLTKDAMPKHNEIREFSKILANYTGY
KIISEHVPSRILLLSRLDKPIQIGNAWTDKWNWSTKDTEDDMNGEYKEAEESCTEGGI
>K0BDF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosopumilus sediminis|TrEMBL
MSCSGETVEEEDRLIQIKPAISDQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEHVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFVRINKPKYDDSWERWNRTLDMLKDLNTRTVL
RITLIREYNDQKENIPAFAEMFKKASPHFIEIKSYMHIGRSTNRLEHANMLEMEEVKKFS
EEIANQSKIFSVMDESIVSRISILQNNERFIDRYIPTYSNTI
>A0A5Q0TTE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. E11-6|TrEMBL
MYNMQSNLRIDTISEIFKELQKEKYHLIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEMKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKILAQY
TGYNILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDMEDDMSGEYKEAEQGCTEGS
T
>A0A7L0R109|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Setophaga kirtlandii|TrEMBL
LDVSMDMWSYFHTCLASIWLHRFYIYSAVALGISLWIVIQFTTTRAKRKKGDQSRGSPSS
PEGTSDKLGNGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAGAVFSLNLPVEIINME
DYDPEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRY
AVFGLGNSAYVDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKD
KFLTRLQALCRGEKKPCRGKCKKGKCKTSGKQSKESSDREHGTSDQDNTEAEELFETSSE
EEAGGTDSVIDVEDLGSVMGHMKKAKVLLFEGVWNAAGAERREMITPALRKALTKQGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMY
PHINHLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGES
SASSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHCKFQVDGEWRTWID
YGRFQELVRERERSGGARTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKARDTSG
C
>A0A7K4F130|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVVEADDPLIQIKPAISAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFIRINKPKYDDSWERWNRTLDMLKDLNTRTVL
RVTLIRNYNDQKEMIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMKEVKKFS
EEIAKQSKIFSIMDESIVSRISILQNNERHIDRFIPTYVNTN
>A0A7K4F9U6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVVEADDPLIQIKPAISAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFIRINKPKYDDSWERWNRTLDMLKDLNTRTVL
RVTLIRNYNDQKETIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMEEVKKFS
EEIAKQSKIFSIMDESIVSRISILQNNERYIDRFIPTYVNTN
>A0A347ALM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. BAmetb5|TrEMBL
MPLSDQNIKTLEKKGYRFVGSHKHSAAKVCHWTKKSIMDDGVCYKEKFYGINSHRCLQMS
PSMPFCHHKCLFCWRDVDVTSTSWAEDYDDPGQIIDECIEAQRKLLVGFFGNPNANQEKV
VEAQDPTNAAISLAGEPLLYPSINQLLEEYARRDFTTFLVSNGLSPRKLGNLDPEPTQLY
LSLDAPNSEVYQRICDPQIPDGWEKLNHSLELLSSFNCRTVIRMTCVAGHNMTHPEEYAR
IIESTNPDFVEIKAYMYVGSSRERLKFENMPRSRDILSFAQNIASLCGREIVDQSLESRV
VLLA
>A0A842MFI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanosuratincola sp|TrEMBL
MNESPERAAGTFEGEYKVLRAQGYHIVGRHSAVKTCHWTKEAILGGEHCYKGKFYGIESH
RCLQMTPAVSRCPNMCVYCWRVLPHEHGFPSVDDRGEDSPEEIVERVIAAQKSALIGFKG
NRRVNMVRFQEALAPKHAAISLSGEPTEYSMLDGLICEFGRRGMTTFLVTNGTNPGRLME
ITEPTQLYVSLSAPSEEVYRSVCRPTLGGSWGKLMESLSLLRSFSCPTVIRMTAIRGLNM
VDPEGYSRIISKSSPTYVEVKAYMHVGFSVTRLGYECMPSHEEVIQFAREIAKRTGYELV
KEVPISRVALLSSIG
>L0HIH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregula formicica (strain DSM 22288 / NBRC 105244 / SMSP)|TrEMBL
MPSDPCEPLRKQGYQFFSKTSTAALKPCMWCKRALAGGDMCYKHQFYGIDSHRCVQLTPT
LRCNQRCLFCWRSFEHEPVESEECSPETILAGIHRFQKKALAGYNAVLDNTVTEERWKEA
LDPKHVAISLSGEPTLYSQLPELIDLFNKTGYTTFVVSNGTNPDMLKRCNPFQMYVSLDA
PDRETYERVCRPLGDYWDRVQESLRLLGSRRSAVRITLVKGLNDIAPERYAAILQDSGAT
YVEIKGYMYLGYSRNRLVRENMPDHADVRAFAEKVATACDYRFKDENELSRVVVLERKR
>A0A151GQR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Drechmeria coniospora|TrEMBL
MAAASKKRSVDYVDLTQDDDDAKRPAHRSRSGLDFKETPVPLPNYVAGSLGGLSAVGPSP
PSSWSARVAASSAAGQSSQSSQSSRSSSAALRSSQSSHSSSSVPASQSGTQEPEFQDLTQ
DDDGQPTELYGSFDGKIVGVRYYNGPVSLLIRKMADFEKYDRNAIRIDNVMFQQIGHLPR
KVAEKISPYLDSGDLTLEAQLTGEQGMFDWPVRLFFFGPSDATSRDRIETALKADKLIKA
TQLKQTRKEAVAQRLSLGLKAGSTTHGVGGAADYGHMELSLEELMKKSDSIDFRQGGDAI
KALAIGEQQLSCMAFAEQPAQLSSVLLPYQLQGLAWMTSKEHPRCPEKRLGNMVQLWKQN
DKGMYWNLASGFVSQSPPNLCSGGILADDMGLGKTLQVISLILTGGPGSTLIVAPVSVMS
NWKQQIERHVKPGQAPSVVVYHGDQKMTIKDLMKYDVVITSYGRLARERDPRVPSVLLNK
SIEWRRVVLDEGHTIRNARTKVATAACEIKAKSRWVLTGTPIVNSVKDVHSLVKFLHLTG
GIEQSEIFNTCVTRKLAAGDRSGEAILQALINDICLRRKKDMKFVDLMLPEKKEYLHRIT
FHPAEKQKYNALLSEARGALEDFQKRSSVGQKGRFQNVLERLLRLRQVCNHWTLCKERID
DLMQLLDNEDIVVFTDRNRALLQEALRLYLESQEECAVCYEIPTAPVITNCKHVFCHGCI
SKAIQIQQRCPMCRNSLTEDCLLEPAPEGAFDDNFDTDTQSSKTEALLQIIRATTANAGS
KIIVFSQWTSFLNIIQNQLKKAEIKFCRIDGSMNADKRDGAIHDLDHDPQTRVMLASLAV
CSVGLNLVSADTVILSDSWWAPAIEDQAVDRVHRLGQTRPTTVWRLVMEGTVEERVLSIQ
SEKRELVGKAFQEKDKTGKKAKDTRMADPSQVRFFHDDGTVKSAHLHLTWSVEAIEFWHA
HRTLVILCAFVTLISIRCYLHFYDRKEGLVVLPKIYEPEKSKDAGAAVPHTSANPKTTAT
KPKGPKRIKGGVVRRASQEEDEAVDLTSPIKVTVYFSSVTTKTEKIARDYMIRLEKATEQ
LGLESKRRFLKPELHDLTEVDFEDVFVTPPVSAEKASSFYLFLLPSYNIDTINDTLLQHL
EETHHDFRIDTAPLSPLLGYSVFGFGDREHWPDESEGFCFQAKELDKWMSKLTGRKRAYP
VGMGDMKSDHAERLEEWSAGVHEVIGHVARTGSLGEGARGSGDAMESDEEDMAGEDDVEV
LVEADDGDKEQASRPLDDVEDLGKMVRPSANNNGGSTKRGPLAVDFTSYGSSGKKRAPAQ
AAVVKEMVAKNSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQ
CMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFQGVKEGHYKKIKMLRGVPGV
RAERYAEALRIRHCALSLVGEPIFYPHINEFLAMLHAERISSFLVCNAQHPDQLAALKAV
TQLYVSIDASNKESLRRIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVED
EAEGYAQLVERGLPCFVEVKGVTYCGTATSSNAGLTMSNVPFYWEVCAFVKALEKRLQAK
GLAYGIAAEHAHSCCILLASERFHVDGRWHTHIDYGKFFELLEERGPDGDWTPEDYMGAP
TPEWALWGQGGFDPRDDRVDRKGRKVENVVVREQPPGEVW
>H0H1U7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7)|TrEMBL
MDGFSLAGAAAVGTLTAAYLYFGGRFSIALVVLVGYGIYCNETDGRVEAKVSLKAEKQKS
CCSNKKTAEGGKTGGCCSDKRKNGGGGGGCCSSKGGKKKSGGGCCSSKNGKKGGCCSSKK
KISNDENVDPVVEEAKNFPMTVDFTDVFKKPTKKRSSIPKIFSKNDPSKSKAGKKLSVSK
KIGPDGLIKSALTISNETLLSSQIFVLYSSLQGAASKVAKRVHDKLAELDELTNKPKLLN
LDELSDLDDYFVDVPVENALYVLVLPSYDIDCPLDYFLQTLEENAKDFRVDSFPLRKLVG
YTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKMEGSTKVDDWTSLLAD
TLKDDEPIIYEYDENADSEEEGEEDNGSDELGDVEDIGGIDSNGKFSSTDEIKQMVAKDS
PTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMEMTPSLACSS
KCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEVR
HCALSLVGEPILYPYINKFVQLLHQKGITSFLVGNAQHPEALRNIVKVTQLYVSIDAPTK
TELKKVDRPLYKDFWERMVECLEILKTVQSHQRTVFRLTLVKGFNMGDVSAYADLVQRGL
PCFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDVAAEHGHS
NCLLIADTKFKINGDWHTHIDFDKFFVLLNSGKDFTYMDYIEKTPEWALFGNGGFAPGNT
RVYRKDKKKQNKEKQGSVKVEAPLPPIPAL
>A0A895ARG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium sp. BOL4-2|TrEMBL
MSESDGPKQVDDPDYHHENHTAAQTCGWTANAMRGEGTCYKHAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHSGHTYELDGVAWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEAM
EPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPAVLRECDPTQLYVSVDAP
ERATFDDVVGATEDDAWERLVDTMDVLHAKDDTRTVLRTTLVGGQNMANPDWYAGFFERA
APDFVELKAYMHVGDSRDRLGRAAMPDHEDVLAFARAVKTHLPHSVLREQPASRVALLAR
DEDTWVEDLRPESAFWTEGARPTAD
>A0A4P6XLN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metschnikowia aff. pulcherrima|TrEMBL
MTNCEAHIGRVPITWVQILHQPHHIFCHFSSSKMDLKAVIFAVCCAIYYLSGGRVTFVIA
AATWYIYSQRGNSTLMPEKPSPILEVDFTHAYMPHEKTIFPKAVPLSAKPKKVTRRTKSP
KVFKGTKLQKNSAEPSLTANTFKLTESPIYIFYTTLTGSSHRVAKALHEKLSNIDELSVP
PKLLSLDDDVDDLEEFFMKTPKSSKPNIYLLVLPSYETDSPIDYFLEHLQETTQDFRVDK
YPLRPLAGFAVLGLGDSESWGGAKFCYQAQLADKWMGKLGARRLFPLGQVCMKHEGEPKA
YDWINRFAELLADDEPFHVDENDAVDDSDAEEEEIDPASDVVDVEDMGAIIRASNGSLTA
MEPKQMVAQDSPTFKSLTKQGYTVVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIRSHLC
METTPSLACSNKCVFCWRHGTNPVAKLNWRWEVDPPEKVLHGALEGHYKKIKQMRGVPGI
QMDRFEEAFQVRHCALSLVGEPIFYPHINEFVGMLHEREISSFLVCNAQHPANLEALAKV
TQLYVSIDAPTKQDLKKVDRPLNSDFWERLIACLDILRTTQAHQRTVFRLTLVKGFNMGD
IKSYADMVERAQPSQIEVKGATFCGSSAGNGNPLTMQNIPFYDECKDFVTSLVGELNSRG
QTYELAAEHAHSCCILIAHTKFHINGVWHTHIDYPKFFELLKSGQDFNALDYVKETPAWA
LWGSDEAGFNPIDTRYDRKAEKLKKKEARDAQAAHVQAIASGM
>A0A2Y9SDM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Physeter macrocephalus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKQVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVAKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRSLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQR
KNKSKDISGC
>A0A090M4W0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ostreococcus tauri|TrEMBL
MSTSRPALEGPLAFALGVSVLGCGFVLGARAAAMTLEYAVGRAGDAGTRARERAATALDS
TSTTGKNLVVYMTTGGTSERFARALATRAAKATGERWTTMDGGDVDDPENTLGGERGITT
VVFVVSTDTGGAAPKRGAWLARWARETAYDERAGWMYLKNLRYAVFGCGNREYGDDFNRV
GRALDAHLARMGAERLVRRRDGDEATGRMEAQFEDWAEKVVKRLASSSRASDVVAKGGLF
EESTSTDDVEGGCGSQDEDALSIAGSEDGQDMEDIGENEGGEPKEMVTPALRGALTKQGY
KILGSHSGVKICRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCTFCWRHHTN
PVGKSWRWKMDEPLELVEQAISEHCKMVKQMKGVPGVLPEKLAEGMEPKHCALSLVGEPI
MYPEIAKFVSELHSRKISTFLVTNAQFPEAIVDLPPITQLYVSVDAATPETLKAVDRPLF
VDYWDRFVNSLKSLKMKQQRTVYRLTLVAGYNMEDIAEYAKLIDLGQPDFIEIKGVTFCG
SSDTSSLTMKNVPYHKDVCKFGEAIVNMRRRENGEEEYGLACEHAHSCCILLARTDKYKI
DNEWYTWINYDKFQRLVVKGEKFTAADYIERTPKWATYGAVEAGFDPEQTRHIKIRNHPG
KDKTAPLIQGEA
>A0A7L4PB12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum arsenaticum|TrEMBL
MSCEYEALGRYHLFEGPRIKVRASAGRALIERHYGVAGHATVELCKWTKDALEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDVFLLDERFYMEPEDIVKGVLE
ERRRLLSGYWGHPQGKRRVREALEPTHWAISLSGEPTMYPKLPQLIKLIKSLPSTKSVFL
VTNGQHPDMLRRLWEEDALPTQLYLSTNAPNKELYYKINVPVYNVENAWEKWLESLDLLA
KIPTRTVLRITLIRSLNYDDRYIPEFAQIVKRGSPHFVEVKSYMHLGHSTFRLKKEDMLS
HEEVKEWSHKLLKELEKIGARFVYMDDDEPSRIVVLQNMDRYVERWIVPPQVKIETQS
>A0A8H7AUD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria burnsii|TrEMBL
MSKSASIPQSARVQKVCTLWTHDDNFSRDEIVFNGEKFPELPTSAGALLQIVAIHTDNAV
RDFYTESKVDTLHNDANGDSHSKRHRRDSITITIDENGSTIPEGRYVDADKAYVFVPKAL
PATMESKYPNLQVSISERIAKVFGFRNRMQVVVTEADEDAHEAHHVEIVFRDEYLARADM
WRMAIAELSKRTVYRGQRLLFMGTIKATIKHIYINGQSVHSGYFSPKSKPIFRSESARYT
LFIQMSREMWDFDTEGAGEIMFNKVVSGFLPDLFKRWLRINARHLVTIILFTRMQYDGEL
LADRPEGTTSNTYADSHSGTFRDYYRVVVSDMASGDWINILYQLKKEFRMFLREVSLVRK
PVKHVNEETGSEDPATDVVVAGRPSSASQGNILEAINLAAAQFAKDYIDRDLVRTGISVI
VVTPGTGVFEVDYNMLKLTTDTLIGSGIGIDLVCLSPMPLHSVPLFKYQTPRSVSDLKAE
HDREQHASPRMSRTEEDKTPRQSQPDFGSMSRASTVRHIPMDVSTDSSDGWRFAMPYWVD
VSFWSGTSEEILELTKPRKADKIVKKSRKKGRIFSLRCRLYELQMMGVMENEVGDIAIPY
LEEDPMYPHHLRGLFEPNGEGLQIAPATKPPAAAAGSYSSRGDKEFNEDQLDETRAAQKA
WMEAYDGGVFSPLIERHSALDQLQARKRRLSDEITSGSPDLSRSLRLSSSFRSTGPSFGK
TARPPSDTNFPQLMRERSKDIESQSPRGSTSRMPNLKSEAVPRADVLRRQNNMTRDNASA
GRPTVHKRGGSGDSQDHRQTVNSTQRHPPAPATSRGSSPRRTGLLPTSVGTPAPAKQDLK
SRPSNWFLRQMSFGGKAAPAKPTLGDATIDISQGKVKPAMLTVEKNQKGAIAERLASTRH
TSTGKPSQPIAIKPASRAGPTSAESLASDRASRSIETVRVARSDRSNVPSQPGSVVRDPG
STFLLAGARGAGEHGGPKPDLSSSGGGREAPRTLSPTSAIAPWAVLVNPCNPKKNIISSK
NQYRRWHHVFPRTLRTGTVKWRSLCSPAAVPLTHEWFPSVDQIASEYNESPYKITQNEDD
DILEAPKSRESLIKELIAFRLSHGFQIIVGSSVAEFSGRQEKTLASILDPEYMSSDGDTV
FMSVGNSIHQLVCVAGGEVEVRRYNRKPTTALESSAGIDTPFSYKPFIRTAFEDTYDPRE
VVLRPPRREYNWNIIDTFLAGYHDEFSEILRFWRARFVLIPVDIPAMHRRPLPMQDSPEE
IRLEGIRKLTQLWQKFRYIPPEERYLQPASTLKQKDPNPLAIEYHTRDPSAVVAAGPDHS
LLNDTDSEFQTSIFSDAEKYHTSSIDIKKLAEDLQGEKGIQMLDRRWHLKLHYNCFLGFD
LTNWLLSNFKDIETRDEAVDFGNELMKKGLFQHVQGRHHFRDGNFFFQIAAEHRAPRVES
RTGWFGMRKTDKSVPSTPLAEAPRTSPLLSKHTKSRPDTADSSSNSSGSLEEGEKTPTRG
EPHKRKVVMSRVMRYDVDPRKRSYRPEIISLHYDRLHNPDNCYHIRIDWMNVTAKLIEDA
IVTWATSVEKYGLKLVEVPIAEVADIVDNHPFRSPYVVKLALQPPQAQPEAMWDSTSFSP
QYPKTDKFAYHKLLLRRLNFVLDMEAASAFPPDVEVTYSWGMPDYKYTQFIHKSGGLLAQ
ISDDGNLLLLANRLAHNRAKDHSRIRPVDPYEHKKATTDGSQSSRLPSTPAVERGNPHRS
PFASPLARPVQDSSLLHTALTFHDPRSAATTPAAASSVPLTPEQVKDEVEAFCSNASLLS
AFYAEAFRHAPSPSPRILPIGEDKIPSLGLPPAISIRDASPATGGWTLSSTFGGPGGIAG
RRQGSEGSMYSMGKRGSVVEGMERAPRRQNSQGSAGTGTKWLLATGMHSNPTNGPHASGL
PKVRTQTRRRRNVESSAMALLELLEPLPAELLFIWHQHRLPILLAALVVATVVRLAIYSR
DRREKLSVSPAPSSPVPVEEKPTVQLKPEWLPEYTTLNSSELNVDNHVDDDTMAVAAAAK
VKKGPKMVKGRKTPKKLVAPATFNHQTDRIQPLVFFQSLSGTTERFAKQFARILTEWTRG
CDQSKSFLEPQTLDISYIEHDDYFVSPPRGDANVKYFYIILVPTYNIDTVLDVFVESLQE
THNDFRIDTAPLSGLVGYTVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLG
MADVKSEAEERLQDWRVGVQDALVEIAQGRGLGEGVPGSGDAIESDEEDVAEDNGQSTRV
DDVEDLGSMVNSSAGPIPVDFTTYKKSPAKSQSLQAPKEMVPTTSPTYAALTKQGYSIIG
SHSGVKICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWITDAPDMIFDGITTAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPH
INELLGIMHSNRISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFW
ERFCACLDILRNRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGT
SAAGSAGLTMENVPFYEEVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRN
DRWATRIDFERFFDLYEGKVEGTRVEDGKVAGWRPEDYVGEETPEWALWGNGGFDPRDAR
VYRKGKGPKVSEEGGKATAAALEF
>E3KDF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)|TrEMBL
MFSLVESITSRFNLTNHTNADRPLNTQVLYSSLSSTTKKLANQLSTSLQSSSQHLHSTLE
SLDHLDLDQLIIQTPVDSTYQLAIFLLPSYNVESPVDSVLAQFRDALFDFRLSKNSLAGL
SFAVIGIGHSDYRDEFCKQAIELDEILEGLGARRLLPLQKIDVAVDPERDLDHYYHSIIQ
KTFHPALKSFSELPTIKSQEIKKYSAENEEEEEEEEEEEQDDVDNSDDEFVDYSNSKPLS
KAEKARQKSKRLLNKKINQGEKKTNGTQDIEDLGVGVPQIENLTSNSKDDAENQMIKKDM
ISPMTRKSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLA
CANKCTFCWRSHTNPVGTSWRWKTDDAEFVVEESLKEHDRLIKQLAGMPGVRPDRFTEAR
TPRHAALSLVGEPVMFHSLLDLPPVTQLYLSIDAGTKESLKSIDRPLHRDFWERFLESID
IVRKKKIRTVFRLTLVKGENSDEIKEYAELIRRGQPDFIEVKGVTYCGYPGSSNLTIKNS
PWHNEVIKFVEDLCEEINDPRYRASSQNGDAQQAPIAEYGLAAEHAHSCCVLAAHQKYYF
DDQWHTWIDYDKFFELVESGQTEFEGLDYCDVTPEFALFGSPQAGFSPEDQRWFRKKTLA
KNNQLEDPLADQTAPSSVGVVVAPGPAQDV
>A0A3Q7NFL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callorhinus ursinus|TrEMBL
MDPLDTWDFSSPLMSLWINRFYVYLGFAFGISLWICFQIVIRKQLFIFKDKNSQKSVPKA
TGDLMKNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKEYD
PDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVF
GLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTKFL
ARLQTLQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGKI
MNYVKKEKREKEQQEEKSSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWQWKMD
QPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMMIKHCALSLVGEPIMYPEINRFLKL
LHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMAN
VPWHEEVIHFVCDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQELVQ
EYEDSGGSATFSAKDYVAKTPHWALFGARERGFDPKDTRHQRKNKSKHISGC
>A0A851UJC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Elachura formosa|TrEMBL
FHVSMDTWNYFHTCVVSIWLHRFYIYSAVAFGISVWIVIHFTSTRSKRKVTEPGTADKLG
NGCAPSQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTCLNLPVEVINMRDYDAEDGLA
EEASSRNICVFLVATYSEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YMDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLTQLQAL
CKGEKKPCSGKCKKGKCKSLGKQNKESSDHEHGMSEHENTEAEELFESSSEEEAGGTDSV
IDVEDLGNIMGHMKKAKVLAALSPWCQSLWVPLCIFCVSILACKLNCLIICALFSGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKLDQPEVILQEAIEKHQNMIRQFKGVPGVKAARLEEALAVKHCALSLVGEPIMYP
HINRFVKLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRKIDRPLFKDF
WQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISIGKPDFIEVKGVTYCGESS
ASSLTMANVPWHGEVLSFVQELARLLPEYGIACEHEHSNCLLLAHHKFQVDGEWRTWIDY
GRFQELVREHEQSGGSRTFTAAEYTARTPPWALFGARERGFDPSDVRFQRKNKAQDISGC
>A0A1D2R2P2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon WOR_SM1_86-2|TrEMBL
MIPKKLRGILEHQHYKIVGNHSAVKVCHWTKKSILDEGFCYKQKFYGIESHRCLQMTPAV
AWCTHRCVFCWRNIEHTIGTEMQQYDEPGDIIDNAIDAQRILLSGFGGIPERVNHKKFKE
AQNPNQAAISLSGEPTIYPKIGGLIEEFNKRKFTTFLVTNGTLPGRLKNLGELPTQLYLS
LDAPNEKTYERIDNPIIPNGWDRIMETVALFPSLETRKAIRLTMVRNWNLGSAKEYALLI
DRSQPDWVEVKAYMFVGASRQRMNLDDMPSFDEITGFSKELERESGYEIKDFKQDSRVVL
LGK
>A0A147JXX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadarchaeum yellowstonense|TrEMBL
MFVSEAQVRELERAGYRFLGRHRHSAVKVCHWTRKSLLNRGFCYKQKFYGIQSHRCLQLA
PGLPFCDHRCVFCWRNTDVTSPGWLGEADEPAEILDQAIAAQRLLLSGFGGNPGVDRKKF
REAQEPNHCAISLAGEPTLYPKINGLIEECRRRGMTSFLVSNGMHPEVLQRMVEPTQLYL
SLVAPDPETYQKICRPVVADGWERLRRSLEILPSLSCRRVIRLTLVKGMNLRDPAGYARM
IERSGADFVEVKAYMWVGFSRSRLSLENMPLHSEIVSFAREVGDACGYRLVDDSEASRVA
LLSRR
>A0A1U8KZK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium hirsutum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPQHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSAGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A2G5H849|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cercospora beticola|TrEMBL
MDRIRLLDLPREALLLYHAHRVEVLLSAGILLAAIRLLVHWRSKKAKALLTPPLGSPVRE
KPLQLVDEKKAASSSIPQTLPAEPLKPKGPKRVKGVRTAKRKDSPVRAIDQIQPYVFYYS
LGGSTRAYAEKLASTFEANDRVLAPIVHDLTEIDYDDYFISAPKQARSGTAAFYYVLLPS
YNIDTELSNFLSHLEETHHDFRIDDQSLSGLAGYSVFGFGDRQEWPTEEEGYCSQAVEVD
RWMAKLTGKKRAYPLGTGDVKGDDADMRLEEWRRGVYNIIEDLGRGQGLGVGVIGSGDPA
ESGDEASEDEDEETLFPAQGRTTKRSTTDDLEDIKAPIPVDFTTTSTKKAPQPAVPKAMV
PKESPTYSSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMEATPSL
ACANKCVFCWRHGTNPVGTSWRWTVDPPDEIFQGMTAGHYQKIKQLRGVPGVRAERFAEG
MQIRHCALSLVGEPIFYPHINELLGMLHASHISSFLVCNAQHPEQLAALGPVTQLYVSID
ASNKDALRKIDRPLHRDYWERFTQCMDILREKRHTHRTVFRLTLVKGFNIDDEAQGYADL
VERALPAFVEVKGVTYCGTSTSKGAGLSMQNVPFYEEVRAFVLALERELKTRGLDYGIGA
EHAHSCCILLADKTRFWRPLGAGDEQNIRTKYEGAGRYRTTIDYPAFFRCVESGQKFGPE
DYVSETPTAEWALWGNGGFDPRDERVDRKGRPKEIEEVKRVVEI
>A0A0D3D0U0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica oleracea var. oleracea|TrEMBL
MASSSSIHARLALVALLSATTLYCIHKYRRLKRLKTLSLNPSTRRGKIFFISETGTSKSL
AQRLHKLLESNGVAFDLVDPTSYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSGCRFGVFGVGSRAYGEEYNAVAKEMSRRMVGLGGAEMVPLGEGDVDDG
ELDRAFQGWCDGVIRVLKGGSAQAQETNEITQNGVVESEDEYIDTTDEEEEDDNNDIVDL
EDIAGKAPSMKNGVVKVAKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKG
ALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIST
FLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQ
RTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALSVKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFT
SRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAIVA
>H6QDT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7)|TrEMBL
MSCEYEALGRYHVLEGTRIKVRASAGRALIERHYGVAGHAAVELCKWTKDALEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDAFLLDERFYMEPEEIVKSVLE
ERRRLLSGYWGHPKGRRRVKEALEPTHWAISLSGEPTMYPKLPQLIKLVKSLPSTKSVFL
VTNGQHPDMLRRLWEEDALPTQLYLSTNAPNKELYYRINVPVYNVEDAWKKWLESLDLLA
KIPTRTVLRITLIRSLNYDERYIPEFAQIVKRGNPHFVEVKSYMHLGHSTFRLKKEDMLS
HEEVKEWSRKLLKELENIGARFIYMDDDEPSRIVVLQNMDRYVERWIVPPSV
>L9WQB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronolimnohabitans innermongolicus JCM 12255|TrEMBL
MSDSADSGVDPGTDADEAADAGDGGAMQVSSPDYHSENHTAAQTCGWTANAIRGEGKCYK
YIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHTYEMDDVEWDDPEAVVDASIRLQKKL
LSGFGGNDEVPREVFDQAMEPRHVAISLDGEPTLYPYLPELIDAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDNVVGATEDDAWEKLLETMAVLAEKDETRTVLRTTL
VDGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSAMPDHEAVVAFAEDVMSY
MPEFTECRGVPESRVALLATQKDTWVPKLKKGSEFWERDPVVGD
>A0A5J5FFM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasma sp|TrEMBL
MQNIYADIYRKEHYGLVGKHSAVKVCHWTKDELLGGPGCYKNTFYGIKSHQCIQMTPALN
ACTENCAFCWRFQGFDSMHISDEDDPEFILEESIRQHLKLITGFKGNPKVSKEIWEEATH
PKHMAISLTGEPTLYTRLGELIAAAKKRGISTFLVTNGTLPSVLEKLDPLPTQLYVTVAA
PNKKIFNELLNPSIGNGWENLMRTLELLPSLDTRTVIRHTLVHGVNMPYLDEYEALDRKA
DPDFIESKGYVHVGSSMTKLQASNMPSHTEILEFSHQLADRMGYYFVADRVESRVAMIAK
DPSKAKIDFNSI
>A0A0N8K0C6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
MWQSRWYGYCAGALLFALWLTVNTAREKGFARNLAEDLHALDLIAEVIDLKDYDPEDSLS
DECTSKAICVFLLATYTDGLPTENAEWFCKWLEEASTDFRYGQTYLKGMRYAVFGLGNSV
YTGHYNTVSKNVDKWLWMLSAARILTRGEGDANVVKSRHGSLEADFGSWKARLLKRLEAL
VRGEKKACSGKCKKGTCKSKSKGKEQLMETSSDAESATGEEADHRSVVDMEDLGNVMNLM
RKAKMRGESLESINNPYLLFYDEVEDSRQELKRRKSEEEEHREMITPALREALTKQGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDPPEIILQEALQNHQNMIKQFRGVPGVRPERFEEGLTAKHCALSLVGEPIMY
PEINAFIRLLHRQRISSFLVTNAQFPEEISDNGEGQGNENSPPSSDEFSTSSGKKDDL
>R8BQC3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaeoacremonium minimum (strain UCR-PA7)|TrEMBL
MTVMCCASWGDWAIYMAWGFWWFDVVISLACAISLPFIVMHRHRPQLNETTAALLLPVVP
AVVASASGGILAEALPNTDHAVTTLVTSYILWGIGESFSMFILAMYFHRLTVHHLPPREI
IVSVFLPVGPLGQGGFGIQQLGKVALKLLPQTASFGKVGTDAIHGGEVLYMVGIFMAFIM
WGAGLGWLMLAGASILTTANFPFNMGWWGFTFPLGVFTTCTGMLAQELSSPFFKVLTMIF
SISVFLLCQLLALMTPSLQLILALTLTQPAVEIWHVYRIPILLATFAILVSVRVYLHFHD
EGEKLPFLQKTFAHETKETVDVPVPNLSSVPRVDEKRTKPSGPRRIKGELQKQKNDDTGA
VELSKRQIKIVVFFSSLTGSTKTFADKYTESLAKAVSTITCDSASTFAEPQLIDLSEVDF
DDYFITPPKSDGSSDLATAYFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLL
GYSVFGLGDREGWPTEEEGFGFQAKEVDRWMAKLSSRKRAYPLGLGDTKKDLSVRLQEWS
EGVVDVLGLIARTGSLGEGVPGSGDPLESDGEDVADEDDGEVMMETSSNGKRAKTGDSGD
LGDVEDLGRLLRDSPKDGRNKAAGAPLAVDFTAYGTSQKRRKQPVQQIKEMVPKGSPTYT
ALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVF
CWRHGTNPVGTNWRWVVDPPQLIFDGVRENHYKKIKMMRGVPGVRAARFAEAMRIRHCAL
SLVGEPIFYPHINEFLGMLHKERISSFLVCNAQHPDQLAALNHVTQLYVSIDASNKESLR
KVDRPLHRDFWERFQRCLDILREKRFKQRTVFRLTLVKGFNIEDEVEGYADLIERSLPCF
VEIKGVTYCGTSTSSSAGLSMANVPFYSEVCDFVTSLDKELNRRGLNYGIAAEHAHSCCV
LLASDRFKVNGKWRTLIDYDKFFQLLEEKGQDGDFSPEDYMGQETPEWATWGNGGFDPRD
QRVDRKGRPIEI
>A0A656YWX7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA259J03|TrEMBL
MVLTKEEKQNMENGGYRLVGEHEHSAVKICRWTKKSLLDKEICYKQKFYEDIHGIKTHRC
LQMTPSLPFCDNKCVFCWRNSEINSPEWRGAVDDPSEILDEAIESQRKLLSGFKGNPKAN
KRKWEEAQNPNLSAISLDGEPTLYPKISDLIEECYRRDITPFLVSNGQNPQVLTEIKEPA
QLYISTVAPDKKTYINVCRPLVSNPWENLIQSLELLPSFDCVKVLRLTLVKDLSLKDPSG
FSKLIKKADPDFVEPKGYVAVGHSRERLGTSFMPTHSEIKKFSKKLAELSGYEIVDEFKP
SRVVLLS
>A0A6G1L404|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Teratosphaeria nubilosa|TrEMBL
MMGVSRVLELPDELLYLWHAHRTEIFLSAGILYAIVRLTLEWRRQKGKHILTPPVLTPLP
ETDTASLPIKAHLIEAEHFDAAIPVSKPAKPKAGPKRVTGKKTKTIQQATAIEKIQPVIF
YFTLGRSTKAYAQSLATLLNDDDPRLLQPQVHDLTQIDHDDFFVSPPKQNGTSYFYILLI
PSYNIDTELHNFISNLDETHHDFRIDTAPLSALAGYAVFGFGDKEGWATEEEGYCSQAVE
VDKWMARLTARKRGFPLGTGDTKGGNVEGAMGEWGQGVKAVIIDVLEGKGLGEGVPGSGE
AVESDDEDEEQAQDTGDVQLAWPARKKKRAAGDDLEDLKAPISVDFTTTRPSSNLPPPPK
PMVPGSSPTYSSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEAT
PSLSCSNKCVFCWRHGTNPVGTTWRWEVDPPDMVFQGMKEGHYKKIKMLKGVPGVRAERF
QEAMRIRHCALSLVGEPIFYPHINELLAMLHREHISSFLVCNAQHPDQLRALGPVTQLYV
SIDASNKDSLRRIDRPLHRDFWERFQSCMDILREKRFTHRTVFRLTLVKGFNLEEEAEGY
ADLVQKALPGFVEVKGVTYCGTSTAAGAGLSMQNVPFYDEVKAFVLALEAALARRGLDYG
IGAEHAHSCCILLADRNRFFKVPKEGGQAKTWHTVIDYPAFFRCLESGKSFGPEDYVGAP
TPEWALWGNGGFDPRDERVDRKGRPKVVEI
>A0A0E3LIB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina vacuolata Z-761|TrEMBL
MRKMPLEEKKENTWEDFLEVPEKNRGEDTALLPFDIPDLKTLLKKQGYALAGRHSAVKTC
LWLRHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPE
KIVEESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPEMLAKVSPSQLYMSLDAPDIETYLKVCQPRSPALWEKINESLSLMK
QKKSRTVIRTTLVKGENLFKPEAYARLIEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSQELAKHLGYEIADESEISRVVLLSKDGRKSPVKKVSGLD
>A0A7L2PC18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pycnonotus jocosus|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKSEKSHGNPSSL
EGTADKLGNGCTPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVSSLNLPVEVINMGD
YDPEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYA
VFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTK
FLTRLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHETTEAEELFETSSEE
EAGGTDSVVDVEDLGNIMGHMKKAKVLLLEGVWNVHGVSHSGYHLVYFVCQFLQAKLNCL
MICPLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHC
ALSLVGEPIMYPQINHFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKES
LRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKF
QVDGEWRTWIDYGRFQELVREYERSGGSRTFTAAEYTARTPPWALFGAKERGFDPLDVRF
QRKSKARDISGC
>A0A8C5LPN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptobrachium leishanense|TrEMBL
MKWKMMGMQAFLCASLLHCVCADHVDADTSGTWDFIYTHLMLLWINRFCIYSCAAVGIAL
WICSHFISRKSKEPKYSSQNGSPVLQTEKLEKENHCSPKEIFVSGVKIFYGSQTGTAKGF
AHLLAEDITGLGLPTDIINLMEYDPDDHLAEETTSKNICVFLVATYTDGQPPKSAEWFCK
WLEEASNDFRYGKTFLKGMQYAVFGLGNSVYSNHYNTVGKNIDKWLWMLSASRIVTRAEG
DCNVVKSKHGSIEADFSAWKFKFLERLQALMEGETKACTGKRKKGTCKSMKTSSTEALAE
EENRADNSENEQTEEELYETTSESEPEEAGEGGSSGLIDVEDLGKAMRNMKKSKNVGSDP
GSPGKPVQSEEPREMITPALQKALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCVETTPSLACANKCVFCWRHHTNPVGTEWKWKMDQPEMILEEAIENHQNMIKQF
RGVPGVKADRFEEGMAVKHCALSLVGEPIMYPEISRFIRLLHEREISSFLVTNAQFPEEI
RCLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKKQQRTKPHPQCNKS
FNNLLLLQYNRHEEGRIKVELWGHSLLYRDKKIQRVILTENKQGWTGTKKIGPGLHPDWP
TPIIQIHRKPVHKSEVTVLEVKAHTATALEQRENKSTFFLKKKNPHQGQPQDFPSGLQQR
FFSSAVC
>A0A803LID6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chenopodium quinoa|TrEMBL
MVSSALASRVTLLALLSATTFYCFYKSRRLKLPSQKFAASARNPKLIYITQTGTCKTLAH
RLHKLLASKGLVIDLIDVKDYEPEDLSKENVVLIVASTWEDGKPPPKAKFFADWIEESAN
DFRVGSLLLSKLKYAVFGVGSGAYGESFDVVAKGISKKLKALGANEVLPLREGDVDGGRL
GKEVDAWGEKLIEILKGVVQENGVIACGKLDDESDAEFVDESDDEDSEESEEEMGVVDLE
DIAGKGPSRNSKNVVQVNGVKTDGKKEMVTPVIRANLVKQGYKIIGTHSGVKLCRWTKAQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPVEIVN
TALDLHTKMIKQMKGVPGVLEERLAEGLLPRHCALSLVGEPIMYPEINTLIDELHQRRIS
TFLVTNAQFPEKIKSLKPITQLYVSVDAATRDSLKAVDRPLFGDFWERFLDSLTSLNEKH
QRTVYRLTLVKGWNAEDVDGYFKLVSLGKPDFIEIKGVTYCGSTATSKLTMENVPWHADV
KAFSEAMALRSEGEYEVACEHEHSCCVLLAKVNKFKINGQWFTWIDYEKFHNLVASGEPF
KSSDYMAPTPPWAVYGAVEGGFDPQYVRYRKERNHKSKCQST
>A0A139HLP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudocercospora eumusae|TrEMBL
MQLAEELVLLWHAHRAEVIVSAGVLLAIVRLTLHWRSRTAKAVLPPLPSASPVELAQTKA
KGPKRVKGVRSVKHRIQPYIFYFSLGGSTRAHADTLASHLPRHDKTLPPILHDLTEIDYD
DFFISPPKQQSSTTAAFYAILIPSYNIDTELTTFIDHLQDTHHDFRIDTAPLSGLAGYSV
FGIGDRIEWPTEEQGYCTQAIQIDRWMAKLTGRKRAFPLGQGDAKGDDLGMRLDEWSRGV
QNIMQDLSEGKGLGEGAPGSGEALESGDEADDDDEGETLVPRKGDTADLEDIKAPIPVDF
TTTSKRSTQPPEPKAMVPITSPTYTSLTKQGYTIVGTHSGVKTCRWTKSALRGRGSCYKF
SFYGIHSHQCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWQVDEPHLIFDGIKAGHYQKI
KQMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQLLAMLHAEHISSFLVCNAQHP
DQLATLGPVTQLYVSIDASNKETLRKIDRPLHRDFWERFIRCMDILREKRFTHRTVFRLT
LVKGFNVDEEAKGYADLVERALPGFVEVKGVTYCGTSTAAGAGLSMQNVPFYEEVAAFVV
ALEKELNSRGLEYGIAAEHAHSCCILLADRKRFYKASQTGGTKRWHTLIDYPAFFRCVES
AKPFAPEDYIGEATPDWALWGNGGFDPRDERVDRKGRPKETTTKVGGGKVVEF
>Q4QJC7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania major|TrEMBL
MISFLLQLFASLGLPLVAFLLYSHLADSVHTGGNVAGGDAGAADDADTFSRQVQAELEQL
GVASAPPSAAPAQSPPPARMAPSPAVAVPPSPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLHTAPPAAAEDVVCPLVRVMEMREEEVGSKNVCRVDTLLEQNQYALTIFITSTYTDGV
APPRSQAFEAVLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGL
GAPPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMAVTSPAAVS
ATEARSCKGGSATVAAANTSVISAAAGGTCGKEGGLCACQQSSQQLCGSSAGGDGDDDCA
CCKAGTIADGVAASASDDDDDNNSNAENNDMDDVEDLVWDGTDDADFDLNKDPSELPELL
YPKLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLAC
ANKCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLATAMQ
IRHCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRDLTPVVQLYLSIDAP
TPEELKRIDRPLFEDYWDRCLSCVKELAKKQQRTVFRLTLVNQYNTENVKAYADLVEMGQ
PDFIEVKGVTYCGTSSSSTLNMKDNVPRHDEVVDFCKALCAEMASRHPHYRTPQMDKEEE
GGGDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRT
DFTSLDYAAVTPAWATYNSKEKGFDPQQTRMVRKNARPTTVTASC
>A0A3N4IC86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ascobolus immersus RN42|TrEMBL
MSTATVQAISLWHTIRFPLIALLVLIFIVRWLSLKHRHIGIDESEASSVPKEKEKKKSTT
INETKIASILAEKAAQTRLPSYPPSAISAVELGEQVATTRAAREEYTPYRRKQSGLTERV
TASPLKLKPSPKRILGSKSMRRQQHSVGVDFDAVQPLIFFASRTASTAQFAETLAGSLFK
EADSVYPTFAIPTPSNEADIAALNSRILPAKVLDLEEIELEDYFLSLPNVDGVRVKYVYI
LLLPSYDPPEESPCFAFLDYLEDTENDFRVDTGILTSLGGFTVFGFGDTSEWGNAKFCRD
AIVADKWLGRLTGGVRGLDSRRIFPLGTGDVNPAAEISVEERLREWKGGVEEAVREFAWT
GLLIGRRGAVESEDEDDTFEKGQVEAENMVDLEDLGKSKDVEALIEEDEVSGGENALLSI
DFTTAGERALKANEPKEMVPNGGATYTALTKQGYTIVGSHSGVKLCRWTKSALRGRGSCY
KFSFYGIRSHLCMETTPSLSCSNKCIFCWRHGTNPVGTSWRWRIDEPEDIFTGVVEGHYR
KIKMMRGVPGIRADRFQEAFKIRHCALSLVGEPIFYPHINRFLHYLHASHISSFLVCNAQ
HPEQLAALDHVTQLYVSIDASDRASLKRIDRPLHRDFWERFQKCLDILREHRTRQRTVFR
LTLVKGFNIDDEVTGYADLVERGLPCFVEVKGVTFCGTTTAAGAGLTMDNVPFWPEVQDF
VERLSVELAKRGLVYGMAAEHAHSCCALLASEEFKNAKTGKWHTLIDYEKFFELLESGKE
FGPLDYVGDATPDWAGWGKGGFNPEDERVFTKGKNRKKNQEAYHAAQKMEQGTREDGGGC
G
>A0A849QKN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinaceae archaeon|TrEMBL
MSKQDEIIDIKGRKDTIDIPDFKTLLKKQGYSLAGNHSAVKTCLWLGRSMKDEGSCYKSR
FYGITSHCCIQMTPTLMCNQGCLHCWRPTEIDVTAPTEWDTPVEIVGSCIAAQRKLISGF
GGSAPRERWLEGNEPKHAAISLSGEPTMYPYLPELVEEFHKQGISTFVVTNGTNPEMLKK
INPSQLYMSLDAPDESTYIKACLPRSPNLWNRINESLHVLKDKETRIAIRITAVKGLNMF
DPAGYAELIKKAEPDFVEVKAYMHLGFSRGRLPREAMPSHDEVMAFAKDIAYHLGYKVAD
DVEISRVVLLSKDGKVSDLVV
>A0A1V8TEA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rachicladosporium antarcticum|TrEMBL
MLNQDFLLPDELLHFWHVHRVEALILAGLLLLAVRLALQWRSKLVIAAKIAGDIKTEESA
PTPALTSRHAEEVKHALPSYVPARPKPGPKRVTGLRKAKPQNVEERTPLVRPIIFYYSLG
GSTRSYATKLAALLSSSAETAQTVPVEVLDLTEIDYDDYFIATPKQTESGRSISYFYLLL
IPSYDIDTELSNFLTHLEETHHDFRIDTAPLSGLAGYSIFGLGDQQEWPTEQDGFCSQAI
EVDKWMAKLTGRKRAFPLGLADTRGSPEVKLQEWAIGVSSVGNDLAIGTGLGEGVTGSGD
AVESGDEDDDAVLDGAESKDDREGDVEDIGGRSPIPVDFTTTSRTKQTNPSAPKAMVPVS
SPTYTSLTKQGYSIVGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCS
NKCVFCWRHGTNPVGTTWRWQVDEPELIFDGIKENHYKKIKMMKGVPGVRAERFSEAMQI
RHCALSLVGEPIFYPHINKLLAMLHAEHISSFLVCNAQHPDELAALGPVTQLYVSIDASN
KESLRKIDRPLHRDFWERFQRCLDILHTKRNTHRTVFRLTLVKGFNVDEEAEGYAALVDR
ARPSFVEVKGVTYCGTSTAAGAGLTMQNVPFYEEVCAFVLALEAALKRRGLDYGIGAEHA
HSCCILLADRERYFLPTGRNGERRWHTLIDYTKFFQLLENGEAFGPEDYIGDATPEWASW
GKGGFDPRDERVDRKGKPKEVLEELPSAVMIREAEVTG
>A0A5B2Z462|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosocosmicus sp. SS|TrEMBL
MSCSGEYYSHNNQGDNLIQITPALKQKLKKAKYGVFNHSAVELCHWTKKSFADEGTCYKH
KFYGISTHRCMEMTPTALNCENRCLYCWRPTEFYDTLNMPAQLVDSPDVIVHSLLEERRK
LIVGFYGSEGINKSKLDESLFPEHYAISLSGEPTMYPKLPDLIKYLFSLKATKSIFLVTN
GQEPEMLQRLSEEDALPTQLYLSTNASNKNMFYKINGPKYKDAWERWLKSLELVSQLRTR
TVLRFTLIRDFNTDLNYLDDFANLVKIGSPHFIELKSYMHVGMSTNRLEQSNMLEMAEVK
KFAEGLKSKLSNYSYVDESIPSRIVLLQNQYRSIDRWIENYRS
>A0A1Y1YCN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clohesyomyces aquaticus|TrEMBL
MHSHSILWRLPAELLLIWHTHRTTILLSVVSLVAIVRLVVYVRGRREKVSLSPTPSSPVE
KVVVELRPEWLPENTTISALNIDNHTEDPTVAVAPAIKTKKGPKTVKGKKLPTKSKQTQA
TFDHTTDKIQPLIFFQSLSGATERYASRLDKELESWISTLENNESPVSILAPQVHDISYI
EYDDFFISPPKSEPNVKYFYLILLPTYNIDTVLSIFLENLQETHNDFRIDTAPLSDLLGY
SVFGFGDKEGWPTELEGFCSQAKEVDKWMARLTGRKRAWPLGMGDVKGDVERRLQEWIQG
VQEVMVEIGQGRGLGDGAPGSGDPVESDEEDVESAEDIDVEPSQPRRAKTKARVDDLEDL
GSLVSKSPASDPTATSGSPIPIDFTTYKSKPKSKPLTQAPKEMVPTTSPTYASLTKQGYT
IVGSHSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNP
VGTTWRWITDAPDLIFDGITTAHYKKIKMMKGVPGVRSERFAEAMRIRHCALSLVGEPIF
YPHINELLNIMHKQHISTFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHR
DFWERFCACLDILKNRRLEQRTVFRLTLVKGFNMADEVRGYADLVERALPAFVEVKGVTY
CGTPAAGSAGLSMQNVPFYEEVAEFVTQLSSELVSRNLPYGIAAEHRHSCCVLLADETRF
RRDGRWATRIDFERFFELFEGKVQGTRMEGREVVGWRPEDYVGEDTPEWALWGEGGFDPR
DTRVWRKGKGPKGEGKGEGEGEGKSGEEGRREVVEI
>A0A8C6CQT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Moschus moschiferus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASQD
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPVAMINLKDYDPDD
RLVEEVTSKNVCAFLVATYTDGQPSESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALCKGERKRCRGNCKKGKCETNQRSSEAAEPESHVQEELHHRDAEEEEPFGSTSEEESD
AEDHQSQNSVVDVEDLGKIMDHVKKEKREKEQQEGETSVTRSTVKSEASERRTMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPVEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVGLIPDYEVACEHEHSNCLLIAHKKGF
RTGGKAAVALLLFYCYTRRQPEKRSE
>A0A8C7BHB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neovison vison|TrEMBL
MDPAGAWDSASPWVSLWTNRFYVYVGLACGISLWICFQMVVRRRDKSSQERSVPKASQDL
GTDGSISLQRKEVSVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVVDLKDYDPDDH
LVEEVTGKNVCAFVVATYTGGRPPHSAQWFYRWLEEAAGDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWTLGAHRVVARGEGDCDVANSTHGSIEADFRAWKARFLARLH
TLEKGEKKPCAGSCKRGQCESSAEEEPFESTSEDESGAEDRPNPNPVVDVEDLGRIVSCA
KREKREKEQPEEKSGLLRSSGKNGPGERRAMITPALREALTRQGYQLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEV
ILKESIENHQSMIKQFKGVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLTLLHEC
KISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALA
AKGVTYCGESSASSLTMANVPWHEEVVHFVQDLVDLIPDYEIACEHEHSNCLLIAHKRFK
VGSEWWTWIDYDRFQELVREYEHSGGSATFGAQDYMARTPPWAVFGARERGFDPKDTRYQ
RKNKSKDISGC
>A0A127BAW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus kukulkanii|TrEMBL
MEIKPGKITVQANPNMPPEIANLFRKQHYELVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTELPQPWDDPAFIVEESIKAQRKLLVG
YKGNPKVDKKKFEEAWYPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPER
LEEMIREDKLPTQLYVSITAPDIETYNRVNIPMIPDGWERIKEFLELMNGIQTRTVVRLT
LVKGENMHNPEGYAKLILKAKPMFVEAKAYMFVGYSRNRLTINNMPSHDDIRKFAEALVK
HLPGYHIEDEYEPSRVVLIMRDDVDPSGTGLEGRFIKH
>A0A4P7NC51|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Magnaporthe oryzae|TrEMBL
MSHPLGTTSSLGNLPSLAVEIWHTYRIQVILSVVAALILLRFYLEHTQGRDKSSVAFANK
FGEENVKDGPSPPPVETQKKSTSLEKTKPSGPRRIKGDVNKTGKNGGAQADITATGREIL
PLVFFSCVTGRTDKVAREYAARLDESLRALPAVPGCSFRESRILDLSEIDYDEYFISVPK
IEAQKEGSRVELLYLLLLPSFNIDTINDTFLEHLQETHHDFRIDTAPLAAILGYSVFGFG
DREGWPTEEEGFCFQAKEVDRWMAKLTARKRACPLGMGDSKTDAPERLSEWHDGVVDVLS
LLARTGSLGEGVPGSGDAVESEDEGGSNEDDDEVLIEENGWTEKKPKKSKSKALDDVEDI
GRMLDTSRANGTAPPVAVDFTTYDKPKGGSRKQPAVQTVKQMVPKSSPTYTALTKQGYAI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMEATPSLSCSNKCVFCWRHGTNPV
GTTWRWVADPPDMIFDGIRSGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINEFLQLLHAEHISSFLVCNAQHPDQLAALGHVTQLYVSIDASNKDSLRRIDRPLHRD
FWERLQRCLDILREKRFRQRTVFRLTLVKGFNVEDEVEGYADMVEKAMPCFVEVKGVTYC
GTSTSAGAGLSMSNVPFYHEVTEFVTALEKSLRKRGLAYGLAAEHAHSCCVLLASERFLV
DGKWHTRIDYEKFFQLLEQKGPHGDFSPEDYMGPETPEWATWGNGGFDPRDQRVDRKGRP
IEA
>A0A7C0XSZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MKPEVKKILEKKHYKVVGNHSAVKLCHWTKKSILDQGYCYKQKFYGIKSHRCLQMSPAVV
YCTQKCLFCWRDTKLTFPEFPIEETDDPKEIIEGCIKAQRQLLSGYGGIPDRINKKKFEE
AQKPNQVAISLAGEPTLYPKLSQLIEEFHNYGFTTFLVTNATLPERIADLDEMPTQLYYS
LDAPSEEIYKKLCNPLLRDAWKRINESLELMPSLDTRKVIRITLVKGFNMIEPESYAKLI
LKAEPNFIEVKAYMFLGDSRERLSLANMPSFSEVMDFAKELDSYLSYGIRSYKEDSRVVL
LSKRKNTKIKQIKCD
>A0A5E4ACQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marmota monax|TrEMBL
MDRPLAAWDLSSPLLSLWMHRFYLYLGFAFGISLWICVQILIKKQGKNSQERSIPEAAQD
LMTNDYASLPKKHIFVSGVKIFYGSQTGTAKGFATILAKAVTSLDLPVAVINLKEYDPDD
HLVEEIASKSVCAFLVATYTDGRPTESAEWFCKWLQEASSDFRFGRTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGARRVLARGDGDCDAVRSKHGSIEADFRAWKTRFISRL
QALQKGETSCGGNCRRGKCESKQHGTEDEEPEPLALAAQQPRDTEEEEPCESSSEEEYGA
GEHQGRNSVVDVEDLGKVMDLVNKEKREEEQQEEKGLFGSRGKKEGGEGRAMLTPVLREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILEGAVENHLDMMKQFRGVPGVKAERFEEGMKVKHCALS
LVGEPIMYPEINRFLQLLHQRKISSFLVTNAQFPEEIRKLKPVTQLYVSVDASTKDSLRK
IDRPLFKDFWTRFLDSLKALAEKQQRTVYRLTLVKSWNVDELQAYAELVSLGSPDFIEVK
GVTYCGESAASSLTMANVPWHEEVVRFVRELVGLIPDYEIACEHEHSNCLLVAHRRFKIE
GEWWTWIDYGRFQELVQEYEDSAPYPLGAAGGDRSVPADLGNRDSDTESVRLLVRLPVNS
YTPGSGLCQNVPSVEARS
>A0A8H7QAS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Umbelopsis vinacea|TrEMBL
MSELVNNIISGFRNIVTFGAEPAVEEQNNSGCCGGNADGGACCNSDSPSKETAGSGCCKA
DDSAASACACADSDEPVEIEHIKIFYASLTGTAKRFADQLQQNLEAAGPKVQVQKITVMD
IVDYDNDDFLTETAICVFILSCYNVEGPLDCPSLLYLTFRFSKWTRDLRYDFRVDRLSLQ
KVRFAVCGLGDSEYGEEFNVASAEIDKWFGQLGGSRIYPLGACDKNADQQAQFSAWTSGF
IAELEDGHALDFHPTNIEYDSEDEDEEIDDGELNKDIGAGDDDASGDEMVDLEDMGKMAS
KIKAAKINRAEEEEAFENSKAKPKRSIGTTVEATAAPVAREMVSPMLHKNLTKQGYKIVG
SHSGVKICRWTKAALRGRGAWRHHTNPVGKTWRWKVDDPEFIVQGVLENHYKMIKQLKGV
PGVKADRFQEAFNVKHCALSLVGEPIFYPHINEFVQKLHERKISTFLVTNAQHPDRIADL
QQVTQLYVSIDASTKESLKKIDRPLFRDFWERFLASLDSLATKGQRTVFRLTLVKDYNTD
DIGNYVELIRRGRPSFIEVKGVTYCGYSGASSLTMANVPYHTEVVEFCKKIVAAVGDDYE
IACEHAHSCSILIASKQFKINNEWHTHIDYPKFFELLESGKPFNSLDYVAKTPEWAIFGA
PEAGFDPNETRFYRKGKNPNEKSTSEVAVAV
>A0A2P5WJW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium barbadense|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKFRRRCLKPLKHLPLNPNPRPGKLFFLSQTGTSKA
LSQRLLDLLSSKNNIPFDLVDPQTYEPEDLPEESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHRGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGEFTRPIVAGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVD
ELHRRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIND
CWRREIMQSRNMAGIKFLKLETSSDSLKALKEKHQRTVYRLTLVKGWNTEDVEAYSKLFV
LGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVRAFSEALALKSEGEYEVACEHAHSCC
VLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFDSEDYMALTPSWAVYGAEEGGFDPDQ
SRYKKERHHKSKR
>M4AFB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xiphophorus maculatus|TrEMBL
QKAAKNKISSDKDGDVHVSGVKIFYGSQTGTAKGFASELSQEVQTLGIPAEVIDMKDYDP
DDRLADEVSKSVCVFLVATYSDGRPTENAEWFCKWLEEASTDFRYGNSFLKGLRYAVFGL
GDSVYVGHYNTVGKNVDKWLWMLSARRVLSRGEGDGNVVKSRHGSVQADFRAWEVRFLSR
LKALARGEKKSCSGNCKNGASCKNRKKHGAQEEEENGSEDQGDGQMVKLTKQNGVMKTAD
EEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPGVKP
ERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHHISSFLVTNAQFPEEIRNLVPVTQ
LYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVEELQAY
AELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPRYDIACEHE
HSNCLLIAHDKFKVNGEWWTWIDYDRFQDLVQAHEDSGGQQSFSALDYTAKTPSWALFGS
NEQGFDPADTRFQRRNKTKDISGC
>A0A523RG88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MVISARELAELERAGYRFVGKHKHGAVKVCHWTRKSLLQRGSCYKEQFYGRELGMRSHRC
LQFTPSLPFCDHRCIYCWRNINVTHSNWVGEVDEPADILDGAISAQRKLLSGFGGNPDVN
KNKLKEAQEPKHCAISLAGEPTLYPKINELVEECSRRGMTSFLVTNGMHPEVLEHISEPT
QLYISVVAPDLETYEAVCQPTVPDGWGRLNRSLELMPSFTCRRVIRLTLVKGLNLKDAPG
YAKFIEKAAPDFIEAKSYMWVGYSRKRLAMENMPLHGEVREFSEALARETGYKLVDESKV
SRVILLKG
>A0A7J2JPD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MPDHVRKLMEKQGYKIILNHSAMKPCYWFRKALMEGRTCYKHKFYGIPSWRCLQMTPTAS
FCNLQCLYCWRLNASDVPLEYRWKEVPDETDKWDDPEDIAEESIRLHRMIVQGYKGVEVF
RREWVYEAEEPKHAAISLTGEPTLYPHIGGLVEAYSRRGMTTFIVTNGTLPERLEKLEKE
PTQLYVTVPAPNERLYMEITRPLWPDAWARMNKTLDLIQSFSSPTVMRIPLIKGFNMDET
VEEFANLVRRSQPTYVEPKAYMWVGYSRRRLERENMPSHDEVRIFARKLAELTGYNIIDE
APESRIVLLSRLEKAIRFF
>A0A6G1WYY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MAVSAEELSELELAGYRFVGEHKHSAVKVCHWTRKSLLNRGACYKERFYGRDLGIRSHRC
LQLAPSLPFCDHRCVYCWRNTDVTTPSWVGEVDDPADILDGAISAQRKLLSGFGGNPNAN
KKKFKAAQEPKHCAISLAGEPTFYPNLSELIEECGRRGMTSFLVTNGMHPEVLEHIAEPT
QLYISVVAPDPETYEAVCQPTVPDGWKRLNQSLELMSCFKCRKTIRITLVKGLNLKKPEE
YAKIIEKAGADFIEAKAYMVVGFSRRRLMMENMPLYDEVNGFARELARETGYSIAGESRP
SRVVLLKKA
>A0A550H2Q8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLPKELRSLYYRQKYRMVGEHSAVKTCHWLSRSLNTKGEEACYKNRFYGIPTHRCMQMT
PSMGHCTQSCLFCWRATPETLGVGWEQTQPIENQDDPDSIIDGCLYHHRKLIYGFGGNPR
VDSGIYEEALDPVHAAISLEGEPTLYPRLGELVEAYKSRGFKSVFIVTNGTKPEELKTLS
SEPTQLYISLCAPDEETYNKTCRPMVPNAWEKVLETIELLDSFNCPTVLRNTLVPKLNMH
SPQKYGKLAELGNVTYMEPKAAMSVGAARERFGYRDMAWFSQIQDFAREIADSCSYNVID
EHRFSNIVLLSRLEKPIRLY
>A0A7J3R095|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKNGVAQVLEKPVPSVLIDALKKQKYHIVGKHSAVKKCKWVHEALVNGRACYKEKFYGIK
THRCMQMTPALFYCTQQCLFCWRAQNTDLKVSWNELDEPFWDAPDLIVQESFKAHRETLS
GYKGHAKANKIKFTEAMMPKHVAISLAGEPTFYEHIGELISTYHKKGLTTFLVSNGTLPK
RLASLREEPTQLYISCCAPNEEIFNVLCRPQVQGAWSRLNETLALLKSFRCPTVIRLTLV
KNYNMKHVEEYAKLIEKATPTYIEAKAYMHVGFSTHRLSHLNMPEHSEICSFATALSETT
GYQIVDESRESRVVLLSKHGKPKRFETH
>A0A497LY86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MALRKQHYHLVGRHSAVKRCRWLYEALINNRFCYKQKFYGIKSHQCIQMSPTAFYCTMRC
LFCWRAQSGDLGIRWEELKLPESWDSPEEIVDGCIKAQLQILSGYKGNPKTNLARYKEAL
HPRHAAISLIGEPTLYEPLGELIHEFHKRGFTTFLVSNGTLPEALSKLSEEPTQLYISLY
GPDEKTFKMISRPQIPNAWEKINQTLELLGSFKCPTVLRLTLVRHFNMKSPELYAKLVEK
ADPTYIEPKAYMHVGFSRLRLQYENMPTHREIGEFAKKLAEETGYKVIDEAEPSRVFLLS
RLDKPIRFG
>A0A497MG18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MASVDLKAEPSWIRLMAERLRIEKYQLVGRHSAVKKCSWLHQSLVHNRYCYKQKFYGIQS
HRCLQMTPSAYHCTLRCTFCWRVHPEDLGLKSPLEAAQPIPEPDDPDFIVEESVKAQRRI
LSGYKAHKSLDRVKYEEALNPAHAAISLTGEPTLYPRLGELIQAFHKRGMTTFLVSNATM
PEVLSNLESEPSQLYLSLHAPTEESFKHVCKPMIRGAFQKVLQSLELLKSFSCPTVLRLT
LVKGLNMEMVEDYARLVVKTEPTYVEPKAYMWVGFSRRRLRYEHMPTHQEVKAFAERLAE
LTGYNIIEEAGESRVVLLSRLSKPIKIKAG
>A0A7C4MFV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MTFYPQELHLRLKRQKYQLVGAHSAVKKCNWLHQSLLYNRVCYKEEFFGIKSHRCLQMSP
TLFHCNFHCLHCWRIMPEDIGLAWDELSPPKQGWDPPEKVFKESFEAQRKILSGYKSLVL
KGKISPSKYAEALNPNQVAISLTGEPTLYPFLGDLIELYKKAGCTVFLVTNGTLPKAISS
LSSLPTQLYISLTAYDYESFIKLNRPLSKDLWNSILKSLEILKSLECPTVLRITSIKGLN
MGASDAFAKIINKYEPLYVETKAYMHIGYSMYRLKRENMPSHDDIKTFAKLIAEKTGYNI
IGESKASRVVLLSKKLLSPKKFN
>A0A086L5D9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii p89|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPRSCFPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKTKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIDDERATGEGSDIDTKGGDRELQSAVFPEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGREARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLAPR
TEGGQEKAPGEETPQSRAAIREEITGEKADKEQGKAKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTS
>A0A2J6MYJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPDSLIKALKKHKYHVVGRHSAVKRCRWLYETLIHNRPCYKQKFYGIKTHQCIQMTPSLF
YCTQRCLFCWRAQSGDLQITWQEMELPKWDSPEEIVKGSIKAQLAILSGYKGNLKADPQK
FKEALRPRHAAISLTGEPTLYEPIGELIHAFHNRGFTTFLVSNGTVPSTMAKLSHEPTQL
YISVCAPNKENHRKVCRPIVPDAWEKLNETLELLQSFSCPTVIRITAVRGLNMENVEEYA
KLIEKANPTYVEPKAYMHVGFSRLRLGYEGMPSHNEIKEFALKLAKATGYKVVDESEESR
VVLLSRLEKPIKFSLS
>A0A7L1DLA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Serilophus lunatus|TrEMBL
LGASMETWNYFPACLVSLWLHRFYIYSAVALGISLWIVIQFTTTKTKRKVTDPTSAFWSE
DNLVNGCATPQAKEVCVAGVKIFYGSQTGTAKRFAKALAEDVASLNLPVEVINMGDYDPD
DCLIEETTSRNICVFLVATYTDGEPPEGAVWFCRWLQEAAHDFRFGQTHLRGLRYAVFGL
GNSEYVGHYNTVGRRVDRWLWMLGASRVLSRAQGDSNVAQSQHGSVEADFGAWKTTFLRR
LQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGTSEQENTEAEELFETSSEEEADA
EEAGGTNSLIDVEDLGNIMGHMKKAKRERELEEGDVGVRESSGRKEEAEKREMITPALRD
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEKILQEAIENHQNMIRQFKGVSGVKAARFEEALTAKHCAL
SLVGEPIMYPEINSFVRLLHQHHISSFLVTNAQFPDEIRSLEPVTQLYVSVDASTRESLR
RIDRPLFKDFWQRFLDSLKALAEKKQRTVYRLTLVKAWNVDELQAYADLISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHQEVLGFVQELTDLLPDYEIACEHEHSNCLLIAHTKFKV
DGEWFTWIDYGRFQELVREHERSGGSRTFSAADYMARTPAWALFGAREQGFDPLDVRYQR
KKKARDISGC
>A0A7J3F8Y2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKGLITNSLPPEIQNLYYKQGYRLVGRRLHSAVKICRWTKESLRSNRVCYKELWYPPVES
HRCMQMTPYIGCNFHCLYCWRIHSGDREGLSWKEFPLSLEDFDEPSEIIDDAIKKRRELL
SGWRGNPRVDKKKFEESLKPTMMTMSLTGEPTLYPRISEMVVEAEKRGMITFLVSNGTMP
EVLERMDKLPFQLYISIPAPDKNTYIKVTRPLIKDAWERLNRTLELLPSLETRKVLRFTV
IKGWNTSNVEGYAKIVEGAKPNFVEIKAYEWVGQSRSRLPRETMPYMSDIEDFACKLASL
TGYAIKGMYEPSGAALLAC
>A0A8B9YFN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus grunniens|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISHPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALCKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHLSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKSF
RTGG
>A0A564Q9C0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanolliviera sp. GoM_asphalt|TrEMBL
MPPKDKKMSQYKEILKKQGDHLVGKNEHSAVKLCYWLKKSLRDEGECYKSKFYGIASHRC
IQMTPYIGCNQNCIICWRPTGMKTSFDEMDSPEEIVEASIKEQRRILTGYKGSYRTNMSK
YEDAVNPKHAAISLIGEPTLYPYLEDLIVEYGKRGLTTFVVSNGTKPEVIEEINPTQLYI
SLESFDEEMYKKMCRPNGNDMWEKVLESLKILGEKRCRTVLRITLVRGLNFEPERFIPLI
ELASPDYIEVKSYMHLGYSRRRLERDRMPTHREIKEFSRILDDKTDYSILDDAEISRVVL
LSKDKGEDRMIDF
>A0A101X3R1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoproteus sp. CIS_19|TrEMBL
MSCEEEPIGRHHAVVGPRLVIRAGTARRLVEAHYGVAGHATVELCKWTRDALDGEGSCYK
VKFYNAPAGGSHRCVEMSPVGMVCSNRCIYCWRPTQEFDEFIPEEWWAMEPEEVVKGVLK
ERERLLSGYWGHEKALERVKEALAPTHWAISLSGEPTLYPKLPQLVKLIRSLPHTKSIFI
VTNGQHPEMLERLVKEDALPTQLYLSMNAPNKELYYLINVPVMNKEDAWERWLRSLDLLA
AMPTRTVVRITLIRSMNYDERYIPLFAQLVKRGQPHFVEVKSYMHLGYSTRRLRREDMLA
HEEVVEWAKRLRDELERIGARYAYMDDDERSRIAVLQNLDRYVDRWIVPPQAR
>A0A0E3QHD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. Kolksee|TrEMBL
MRKMPLEEKKENTWEDFPDVPEKNRGEDTALLPFDIPDLKTLLKKQGYALAGRHSAVKTC
LWLRHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPE
KIVEESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPEMLAKVSPSQLYMSLDAPDIETYLKVCQPRSPALWEKINESLSLMK
QKKSRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSQELAKHLGYEIADESEISRVVLLSKDGRKSPVKRVSCPD
>A0A7C1E8T1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fervidicoccus fontis|TrEMBL
MTIRITQVDYSNLQKLMRKQGYHFVNEHTVVKPCLWTRKAILQRRFCYKCLFYGIESHRC
IQMSPAAYWCWNDCIHCWRVRPPDVGIPFELSMPKYQEDIDALVDNIIETQRKLLSGYWG
NPKADKELVKEAFEPKHVAISLTGEPTLYENLPSLIKAFHRKGLTTFLVTRGVRPDVLER
LSSEEPPSQLYISIEAYNKEKYEQINKPLVPRAWELTMRSLEIMSSFPSPTVLRITAIKG
INMDSNAVEGFSKIIEIARPKYIEVKAYMHVGSSTQRLTKNNMPSFSDIWAFSEELSKAT
GIPIRSYAKDSRVVLLSELERPVRHGKGCPNYLWLSKS
>A0A0X8I957|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobus sp. 7A|TrEMBL
MEERQLSEEAIYDILNQRLIKQGYHIIGHHSSVKKCYWNHAALVEGRFCYKGKFYGIESH
RCIQLSVTNHWCWNACLHCWRLRPQDVGIEWNETRMPFVDDPKEIVEKAIQEYRRIMSGY
KGRPGVKPEMYKEAVMPKHVAISLTGEATLYPRLGELIEEFHRRGISTFLVTRGVRPDVL
ANLEEEPNQVYISLESWDKESYNYFNRPLVPRAWELTLETLEMLPSFSSTTVYRLTIIRG
YNDKEEAIRGFAKLVDLGRPDYIEVKAYMYVGASRNRLRLDNMPRHQEVKEVAKRLSELT
GYPIVSESLPSRVVLLSKLERPIRYGNAPVDWNSPDIPAPGEYESES
>A0A2E5VYZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIASRLSKQRYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLHKIDDDPYELYLESVRAHRRLLTGYGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDVCHQHGTSTFLVTNGSLPKVIEELDPLPTQLYVSVDAP
NKEIFDRICKPKFDQNAFHKLEQTLELLPSLDTRTVCRHTLIKHESLGHHEDYARLDNIA
DPDFIEAKGYVFVGNSRNNLSIDNMPTHAEVMEFSETLAPMVDREVLSDRRESRVALIGR
EMVPVTLPEKTRELPSDLGIAKPQRFVLPQA
>A0A2E6C568|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACSYCWREPHMDTLELSDQDPLEMLYDSVKAQRRLLSGFGGNPKVPREKFLDAQNP
KHVAISLNGEPTLYKRLSEYMELCHSHGMTTMLVTNGTLPQVLERLDTLPTQLYVSVDAP
NKKVFDEICRPKWNSAGWSRFEKTIDLLPSLDTRIVCRHTLIKGRNMNKEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSNQLAPLTGRKLLDDSPPSRVALV
GKEIIPIPIPEATMHFPDDLGIAKSVKHLKIVQ
>A0A2E4V314|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MQXPVTKIEPEIAARLAKQSYHLVGEHGGVKVCHWTKQSLVADRSCYKGTFYGIESHGCM
QMAPNVDTCNLACTYCWREPHSDALTKIDDDPYELFLQSVKAHRRLLTGFGGHPSVPREK
WLDAQDPKHVAISLNGEPTLYSRLAEFLDICHQHGVSTFLVTNGSLPKVIENLDTLPTQL
YVSVDAPNKEIFDRICKPKFDQSAFEKLEQTLELLPSLDTRTVCRHTLIKGESLGHWNDY
ARLDNIADPDFIEAKGYIYVGNSQSNHTIENMPSHXEIMEFSRNLAPLVGREVLSDRRES
RVALIGKEMIPVTLPTKTRDLPKDLGIAKPQNFSLPQL
>A0A7J9Q132|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDDDIKAILEKQHYHVVGQHSGVKLCHWLGEKLLRARPCYKESFYGIESHRCLQMSPAVN
NCTQTCLFCWRYQGLLENDIPQEDDPEDILQGAIEGQRKLTTGYKGDTRCSTEMWKEAQD
LTNVAISLSGEPTMYSKLGEFIEACHKRNMTTFLVTNGTMPEVLENLDPLPTQLYVTVAA
PNEEIYKKLCVPLQRDGWERLNRTLELLPSLGTRTVIRHTLVDGWNLGWEKEYARLDDRA
NPLFIEPKGYVFVGYSRERMHNHNMPSQDKIMEFSLKLAAETGRKVLAEQRPSRVTLIGA
DGSKMKIRGE
>A0A2E5B792|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLVLNDQDPLEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEIFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRTLAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMHFPDDLGIAESIKHLKIVQ
>A0A534LMU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGIGCYKQTFYGIESHRCLQMTPAVD
ACNLACQFCWRTQEWGSNSLLAADDPAFIVDESIRAQRELLTGYKGNPNVTRERFMEAWH
PTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQLYVT
VAAPTAEIYRRLVAAKSDNEWRKLKETLALLPTLPTRTVVRHTLVEGWNLGWEDEYAELD
RLGKPMFIECKGYSFVGESRLRLQAENVPSHASIRTFAERLADRVGYQIAAEREDSRVVL
LTQDGALHPISP
>A0A7J3AMU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MADTGARAKLEWQGYKLIGSSFGVKGCHWLKARLLHGKPCYKEKFYGIRSHRCLQMTPTV
DICNCQCLFCWRFHGMKDYPRASKEDPAEILDELISAQREIVSGFKGDMRCDKGLWEEAR
NPKHVAISLSGEPTLYPGLSDFIGECSRRGMTTFLVTNGTNPKALERLEHLPTQLYVTIA
APNEDIFERLCLPRGPGLWDKILRTLELLPSLDTRTVIRHTLVAGWNLGWEPEYARLISR
ANPNFVEAKAYMFVGDSRNRLTIENMPGHDLIRTFSERLASELSYLIIDEHRDSRVVLLS
NGSREPRMVE
>S0APA5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ferroplasma acidarmanus fer1|TrEMBL
MINNYEAVYKKQHYGLVGSHSAVKVCHWTKSELLGKAPCYKNTFYGIKSHQCIQMTPALN
QCSENCDFCWRFQGFDSMHINEEDDPEFILEESIKAHLKLISGFKGNPKVKKELFEEASH
PRHMAISLTGEPTLYTRLGELIEAATRRGITTFVVSNGTMPKVLETLNPLPTQLYITVAG
PTKEIFNDVLHPAIGNAWENFNKTLDLLPSLDTRTVIRHTMVKNVNFPFYDEYEKMDRRA
DPDFIESKGYVHVGQSEGRLTAENMPSHDEIMEFSSTLAKRLGYTEYADRFESRVAMIAK
HPEDAKIDVDREIRKTLDKLEITEN
>A0A7K3YEG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MRSEACKALRRQGYQFVNPASSAAVKPCMWNKRALKGGDMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVVEEEECPPDEIIGNLRRLQKRALAGYKVSPYVAPERFAEALD
PTMVAISLSGEPTCYSHLPELIDGLNQDGYTTFLVSNGTRPDVLARCRPYQIYVSLDAPD
RETYLSLCRPKEDYWEKVQESLTGLRERRSAIRTTVVRGYNDFAPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRTQMPEHREVRAFSEKIAEHCDYHIKDESPISRVVCLERDV
>A0A7L0DZR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trogon melanurus|TrEMBL
LDVSMDTWNFFHTCLVSLWLHRFYIYSAVAFGISIWIVILFTTTKPRKKVTEHVRIQRQL
VNGYATPQVKEVYVAGVKIFYGSQTGTAKRFAKGLAEIVISLNLPVEVISMGDYDPDDCL
SEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKSYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKEKFLSRLQA
LCRGEKKPCSGKCKKGKCKSAGKQSKESSDHELGASEYDNTEAEELFETSSEEEADAEET
GSTNSVVDVEDLGNIVGHMKKAKKKGIKIRTREAQFSNTSLVTFGWSRHIFTFDSFVSFE
SYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEMILQKALENHQNMIKQFKGVSGVKADRFEEAMRAKHCALSLVGE
PIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRP
LFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTY
CGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLVAHKKFKIGGEWC
TWIDYDRFQELVQEHERSGGSKTFTAADYTARTPRWALFGSRERGFDPLDIRYQRKNKAR
DISGC
>A0A2T2N8U6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corynespora cassiicola Philippines|TrEMBL
MASHELLEQLPAELLVIWHTYRVPIIVSLSALVAVVRLSVYLRSRRAKVSGSPTPSSPVE
KKTIELKPEWLPENTTINPSVLNLDNHAEDTVAPAIPVAKVKRGPKTVKGRKISKKSLET
GALFDHKVDKIRPLVFFQSLSGTTERYASQFTKTLIDWTTGCDQSLTFLEPQVHDISYIE
YDDFFISPPKTEANIKHFYVILLPSYNIDTVLSNFLENLQETHNDFRIDTAPLSGLLGYS
VFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKVDAESRLEEWRLGV
QEALVEIAEGRGLGEGVPGSGDPAESDEEDLDDAEDTDSESSSRKIVKKKGTRVDDVEDL
GSMVKADDSSGAPIPIDFTNYKSKPASKPVSKPVQAPKEMVPTTSPTYASLTKQGYTIIG
SHSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWVTDAPDVIFDGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INELLNIMHSQRISTFLVCNAQHPAQLASLVPVTQLYVSIDASNKESLRKIDRPLHRDFW
ERFCACLDILRARRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGT
SAAGSAGLTMQNVPFYEEVAAFVTELEKELLSRGLDYGIGAEHAHSCCVLLADRNRFMRD
GKWATRIDFERFFDLCEGKVEGSRMERQEDGSDKVVGWRPEDYLGDDTPEWALWGNGGFD
PRDQRVWRKGKGPKNEGENEGSVKLVEI
>A0A2S7PHE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rutstroemia sp. NJR-2017a BVV2|TrEMBL
MADGTLSFRPFWAFESSGMLPICEILLSILLLICNADIVALWHLYRIPIILTTATILIIV
RITLRPRALREKISASPVPASPALSAVKVKEKIAPGEFDEKKSNGLKAPRRIVGGVKKRK
SSDENTNSRDQKIQVLVFFSSLTGTTEKTAQVFTEGLKQNLLEANAEEKNSKYLEPQLLD
LSYIDYDDYFITPPKGDAETSYFYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSS
LLGYSVFGFGDREGWPTEEEGFCSQARDVDKWLAKLTGRKRAFPLGMGDTKTDAKDRLKE
WKEGVEDVLSHIARTGNLGEGVVGSGDAVESDVEDLEEDDDGEVLFDEQNVASRKAKTQK
KDTLNDLEDIGGGLNNTESADKEMTEEEAADLEVDFTTYSLKKAKTKAAPAVVKEMVPKN
SPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCS
NKCVFCWRHGTNPVGTTWRWQVDPPDMIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRI
RHCALSLVGEPIFYPYINEFTSMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASN
RESLRKIDRPLHRDFWERFQRCLDILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEK
GLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVCAFVEALTAALQKRGLKYGIAAEHA
HSCCILIASERFRFEGKWHTRIDYEKFFQCLESGEKFGPEDYVGPETPEWATWGNGGFDP
RDERVHRKGKNKVPLTESQGGVKAELVEI
>A0A667YTD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
IRIDWSRQQTHSNCSKQFCTQSKEKQILKPQSWLLSGFAKDLSDDVKALGIAAEVIDMKD
YDPDDRLADECSNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLRGLRYA
VFGLGNSVYVGHYNTVGKDVDKWLWMLSGMRILTRGEGDCNVTKSRNGSVQADFQAWKVK
FLSRLQDLAKGEKKSSTGSCKSGSGSCKSRTKRSQGQSEEEKAALHDNFEVMMEERSIKF
LILLVWLLVVNVLTPEGSRLVNGVKKIENEGERREMITPALREALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKM
DPAEKILQDALEKHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLR
LLHTHRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDS
LKALGEKRQRTVYRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMA
NVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELV
EAHERSGGQRSFSALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A2H9RBZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon CG_4_9_14_0_8_um_filter_34_10|TrEMBL
MSCSGEIVDEERLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVSEPKEILTKLMEERKKLIMG
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEP
DMIQRLQDEDALPTQLYLSTNAADYDSFLKINRPKYDDSWQRWNKTLEMLKRLDTRTVLR
ITLIRDYNDQKEMIPAFASMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVRKFSE
EVAKHSQIFSIMDESIVSRIVILQNNQRTINRWISAYSSTS
>A0A419KDP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MEPKATLKLKYDEEDVTRKTLEKQGYHFVGLHKHSAVKTCLWLWKSIRGEGNCYKGKFYG
VSAHRCVQMTPSIFCNQRCVHCWRPLEAFTIGRETKLMKQPTKWDSPEEVVDGCIKEQKR
LISGFKGSPKTNRTAFMEAEVPKHAAISLIGEPTLYPYLKELIQEFHSRGMTTFVVTNGT
NPDVLREISPSQLYLSLNAPNEAIYKKVAHANYWSRIKESLEELRMKKGRTRTVIRITCI
EGINMVNPGGYAELLKIANPDFVEVKAYMHIGYSRKRLPREAMPSHSRVKQFASEIEEAL
ASICDYGYKFEDESEKSRVVLISVGHERFLQLNHRITQISTRK
>A0A5J4Y6H8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trebouxia sp. A1-2|TrEMBL
MRGTPGGVWTRRKFLHIQTKRHPDQTKRICKGPAGTGCHCADLPQSQSKQPAAAAAARLP
GKVLYGSQKGTAAAFANQLVRQAATFGVELQAMDLESYEVEQLWKEHLVLLVLSTYENGS
APDSARWFCQWLDESSTDFRVGAEPLASLSFAVFGCGNSLYTDHFNMVGKTVDRQLSAMG
GQKLAPFGCGDEDCGKMQEQFQSWAQGILEAQSKQTSSDAFVDPVDPIITQEDTASEGYA
TSDEESSSESGESPAAGGSDDDMDMEDLGGRVVSGKAASTSQAASQQPEPEAAAAREMLT
PALRANLSKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHQCMETTPSLACA
NKCVFCWRHHTNPVGRDWRWKMDDPLTIVHGAIDNHVKMINEYKGVPGVQAARLQEGYQV
RHCALSLVGEPIMYPEINAILNELHQRRISSFLVTNAQFPDRIRHLVPITQLYVSVDAAT
RDTLKAIDRPLFKDFWERFRECLTLLRDKHQRTVYRLTLVKGWNMEEIANYAALLDLGKP
DFIEIKGVTYCGSSGASSLTMQNVPYHADVCEFGEAICKARNGEYGLACEHAHSCCILLA
RKDRFWKDGRWHTWIDYDKFQAMVAAEETFVTTDYMLPTPDWAVYGAHEAGFDPQETRFK
KIRNHPQKQS
>A0A151LTB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium gaboni|TrEMBL
MGIGDQEFLLKNILGTHCNEKKVKINISVIYGSGDGNSYNRAKDFLNELIEYFNNVHLFL
NDINEIINKDIYIKHVNSKNNYSDVVQKKDYNEKKIEIINNYKNHKCDDHDNVGSNIIFK
SNHINPSLNRNHMNILENEIIEYFKLRFDQYQVNNNNNNKKKKNKEEISRSGYENMVTLY
FNKNINYLESYKENIKTFNSKFRNYVDCIIDNNKIGKIYFNLIDGNNHDYYSFFDSTENY
NLNILFFFISTSSHGSFPNNSFKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDK
YFCIPIKKCEKYIHSLGAQKLYKTLKLCDTQDNEETLFLWKCNIFKTLSLSLFFYSFNYM
KRWYMNKTIYDTLSYYCYFFSNHTNFYVNQSEDNKYIHDQEEKKKKKKKKKKKKKKKNSH
DHSINSMDILQVCHSNKEYKENNALIDHNNNKCFNNEIYNTHSGIYYSNVKDVQQMCLSN
IDNEENNLVNNEKKKIKDKTNITMNEKREEVDVNEDIDLLHGDIQKIEGCTNCNCESMNE
YNDKNNTYHTNHLSNTNNVETYKDSTSESEASNNDSYVDDEDEQIEVEDLISGEKKDMLS
SSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACA
NKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIIIERFEKAMNI
KHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPAELQNLNPVTQLYLSIDAPN
KEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEINSYINLIELG
YPDFIEIKAVTYCGSSQGYQLTMKNIPWHEEVYQFAWNLINKKKSLSHIYEISCEHKHSC
SILIAKKIFKINNKWNTWIDYEKFQQLIKNKENFNALDYSVETPHWAIYGSQESGFSPCE
KRVYTKGKYKNKNQPS
>A0A7C5TBT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulcanisaeta sp|TrEMBL
MERTTQLIKEQLKYHVIGEVSGRVKLRISDEAKVKLMKAGYGIYNHSTVELCHWTRSALT
QEQSCYKFKFYGAPAGGSHRCVEFSPVGMVCSNRCVYCWRPTDTFDSFTPNEGLVDDPEE
LIRGVLMERYRLLTGYFGHPKARERAREALTPTHWSISLSGEPTLYPKLPQLVRYLRGLP
STKSIFIVTNGEHPEMLERLQREDALPTQLYLSCNAPNRELFYRINVPVMYREDAWERWL
RSLELLSKVNTRTVIRITLIRSLNYDPRYIPEFAKLMVIGNPHFIEVKSYMNLGHSVYRL
SRGDMLTHEEVRDWAMKLLDEVNRQRGNFRYMDEDPPSRIVVLQNMSRYVDRWIVKPEQQ
PGVLSEADKRKLEDALRKYGGPRVS
>A0A366MCA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp. NOE|TrEMBL
MYNITNYLCNYNIFLDMSSDFDSNSLQDKNDAEKSPALNLEEQSKLEYSGYRFVGKNGHA
AAKICHWTKKSLLNEGVCYKEKFYGIESHRCLQMSPAVPFCHQKCSFCWRDLSLTKTEWV
GDYDDPKTIIKDAISAQNKLLCGFGGNDKTDKKKFKQSKNPNNAAISLAGEPMLYPDIDG
LIEEVKKQDFTTFLVSNGLMDEKLANLENEPTQLYISLDAPDKKTYQNLCNPQINGAWEK
VNNSLETLNNFDSRTCIRTTCVKHKNMFGHEKYAQLINKTDPDYIEIKAYMCVGYSRERL
TLDNMPTFQEVTKFAEKIANLTGRKITNDSEISRVVLVE
>A0A2H9LUJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon CG06_land_8_20_14_3_00_35_12|TrEMBL
MKTNVSSELKKKHYGLFGNAGTEVCLWTKKALRNEDVCYKQKFYGIPCHRCMQFSPLIAC
NQNCLFCWRPTEIMHSGKISGKIEEPEKIIENLIEERRKLLTGFGANKKNRKKWQEALKP
CHFAISLIGEPTLYPKLPELMSLLKQRPETKTIFIVSNGQNPEMLLKLKKKNALPTQMYL
SMNAPGEKLFREICRPCSDRAWKIYLKSLKILKSLRCRKVIRMTIIKGLNDNYEFLPEYA
RLIRLAEPDFVEVKAYMRLGYNRQSFLWENMPSLKDIEKFSEKLLKELKNFKKADKNRLS
RIVLLKNKKTKFRQKIFD
>M0K578|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula californiae ATCC 33799|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRELLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVRAFTREMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A8G2L7I3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Picrophilus oshimae DSM 9789|TrEMBL
MINNYKLIYKKQHYGLVGKHSAVKVCHWTKSELTGKASCYKNTFYGINSSQCIQMTPALN
SCTENCEFCWRFQGFDSMHIGDEDDPEFILEESIKAHLKLISGFKGNPNVSSEAWEKAMH
PKHMAISLTGEPTLYTRLGELIAAATKMGISTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKEIFNRVLNPAIGNAWENFNKTLELLPSLDTRKVIRHTLVKDVNMPYYDEYEKLDRKA
DPDFIESKGYVHVGQSIDRLTADNMPSHEMVLEFSNEMARRLGYTPYADRRESRVAMIAK
DPSKARIDFDSVLKKAMEKIS
>A0A1S8BEN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diplodia seriata|TrEMBL
MLDNFLEHLQETHHDFRIDTAPLTGILGYSVFGFGDREGWPTEEEGFCSQGKDVDKWLAK
LTAKKRAYPLGIGDVKSDAQDRLKEWRLGVQDILLDVCAGKGLGEGVAGSGDAVESDEED
IDDDEVESETAQPTKPKKTKAKSSLDDVEDLGKMVKSEIDPDEPMEVDFTTYKKPVKAAA
PAAPKEMVPKSSPTYSSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHL
CMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEKIFEGVKEGHYKKIKMMRGVPGV
RAERFAEAMRIRHCALSLVGEPIFYPHINEFMAMLHKEHISSFLVCNAQHPAQLATLKQV
TQLYVSIDASNKESLRKVDRPLNRDFWERFCACLDILREKRFQHRTVFRLTLVKGFNMAD
EIAGYADLVERGLPCFVEIKGVTYCGTATSAAAGLTMQNVPFYAEVQEFVEALNQELNSR
GLEYGIAAEHAHSCCVLLASTRFRKQVDGEWKWCTLIDYDRFFQLLESGEDFKPEDYMGE
PTPEWALWGNGGFNPEDERVYRKGKNKVKAVEEAPKPIVEI
>A0A6J3GSY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapajus apella|TrEMBL
MPFTFENEVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVF
GLGNSVYASHFNKVGKNVDKWLWMLGARRVVSRGEGDCDVVKSKHGSIEADFRAWKTMFI
SQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSEEQDELHHRDTEEEEPCEGSSE
EEFGGEDQQSINSIVDVEDLGKIMDHMKKQKREKEQQEEKTSLFGNTGRNEDGERRAMIT
PALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMV
KHCALSLVGEPIMYPEINSFLKLLHQRQISSFLVTNAQFPAEIRNLKPVTQLYVSVDAST
KESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNP
DFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAH
KKFKVGSEWWTWIDYNRFQELVQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKD
TRHQRKNKSKAISGC
>A0A6J3GRZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapajus apella|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGFVSLHNKDIFVSGVKIFYGSQTGTAKVTGRNVCVFLVATYTDGRPTESAEWFCKW
LEEASRDFRFGKTYLKGMRYAVFGLGNSVYASHFNKVGKNVDKWLWMLGARRVVSRGEGD
CDVVKSKHGSIEADFRAWKTMFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEG
SEEQDELHHRDTEEEEPCEGSSEEEFGGEDQQSINSIVDVEDLGKIMDHMKKQKREKEQQ
EEKTSLFGNTGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQ
NMIKQFKGVPGVKAERFEEGMMVKHCALSLVGEPIMYPEINSFLKLLHQRQISSFLVTNA
QFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRL
TLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVLEL
VDLIPDYEIACEHEHSNCLLIAHKKFKVGSEWWTWIDYNRFQELVQEYEDSGGSKTFSAK
DYMARTPHWALFGASERGFDPKDTRHQRKNKSKAISGC
>A0A7K6G856|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Malurus elegans|TrEMBL
LDVSMDTSSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFATTRTKRKVTEPKSHGSPT
SSEGPADKLGNGCASPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVISLNLPVEVFNM
GDCDPEDCLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLR
YAVFGLGNSAYVDHYNTVGRRVDRWLWMLNASRIMTRAEGDCNVAQSKHGSIEADFEAWK
TKFLTRLQALCRGEKKPCSGKCKKGKCKSLGKQSKESWDHEHGMSEHENTEAEELFETSS
EEEAEGTNSVIDVEDLGNIMGHMKKEKVLLLEGVLNTTGVFSASILADDAKLICLMVFAL
FAGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPELILQEAMEKHQNMIRQFKGVSGVKAARLEEALRVKHCALSLV
GEPIMYPQINRFVRLLHQHDISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRID
RPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGV
TYCGDSAASSLSMANVPWHGEVLAFTQELAQLLPDYGIACEHEHSNCLLLAHRKFQVEGE
WRTWIDYGRFQELVRERERSGGARTFTAAEYTARTPPWALFGAAERGFDPSDVRFQRRNK
ARDISGC
>A0A830FTG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halarchaeum rubridurum|TrEMBL
MPEQVDSPSYHHENHTAAQTCGWTANALRGEGTCYKHAWYGIRSHRCIQMTPVVRCNERC
VFCWRDHNGHAYELDGVEWDDPEAVVEASIELQKKLLSGFGGNENVPRERFEEALDPKHV
AISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEVLRECDPTQLYVSVDAPERATF
DDVVGATEDDAWESLIETLDVLHDKDETRTVLRTTLVNGENMTNPDWYAGLYRRADPDFV
ELKAYMHVGHSRGRLDRDSMPSPEFVAAFAERVGEHMPDHPVVKVQEASSVALLARDEET
WVPELAPGGGFYD
>A0A0V8RW07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrodictium occultum|TrEMBL
MAQLEFKPRTVRGKRWKYRIDDFPEPYRTLYRILERQGYIIVGRHSVVKKCHWTHAALVE
NRFCYKCKFYGIESHRDVQMSPAALWCWNACLHCWRLRPTDTLKWDDTKLPWVDDPDLIA
EGSIEAHRESLMGYWGHPKFNERMKRMLEEAMNPVHVAISLTGEPTLYPRLGELIQEYHK
RGMTTFLVTRGVRPDVLANLEEEPSQLYISIEAWDKSSYNKFNKPLVPRAWELTLKTLEL
LPSFSSPTVIRFTLVRSFNMHEDALKAWAKMVEIAQPTYVEFKSYMHVGAARNRLSRTDM
LRHLEILAFAKKFADMTGYKVISQQIESRVVLLSRIDKPIRLGKGCQGEMEKEKDRLEEM
LEALKKNPSLDETEYRMVLEQKI
>A0A8B8VCD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Balaenoptera musculus|TrEMBL
MLRGISGSFPVSTPDNPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNK
NSQEKTVPKASRDLMTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAKAVSSLDLP
VAVINLKEYDPDDHLVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEDAANDFRFGKT
YLKGVRYAVFGLGNSAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEA
DFTAWKARFISRLQALCKGERKPCGGNCKKGKCESNQRGSEAVEPGSHAQEGSHQRGAEE
EPFGSTSEEESGTEDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSAVKNEA
SERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNMMKQFRGVPGVREE
RFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRNLKPVTQL
YVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYA
RLVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVNLIADYEIACEHEH
SNCLLIAHKKT
>M0AB24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba taiwanensis DSM 12281|TrEMBL
MSDSADAGVEVGADADPDQGRDRDGNDGDPAGGPAQVSSPNYHSENHTAAQTCGWTANAL
RGDGRCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDA
SIKLQKKLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITT
FLVSNGTRPEVLRECDPTQLYVSVDAPERHTFDQVVKAVDDDAWDRLLETMAVLRDKDET
RTVLRTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVLE
FADAVKSYLPEFSECKGVPSSRVALLSKTSDTWVPKLKKGSKFWARDPVTGTGD
>A0A842NCP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MLKQLSDKKYKDTLEKQQYRIAGSHSAVKICGWTKSMLRDEGGCYKLKFYGIMSNQCLQM
TTSMSCANRCEFCWRGYKAPVSKDWKWAVDDPEEIIEQSIAAHHKLLIGFKGFERLNKKA
YEQSLEVKHVALSLTGEPIIYPKINEIIDLFHKRGISTFLVTNAQYPEEIKKLRPITQLY
ISMDAPNKKLLKKIDKPLFKDFWERFNKSLEYMAKRNDRTCIRITVIKGKNDVEPENYAH
LIEKANTYFIEVKAYMHVGESRERLKEDNMPTHEEVVEFSKEINKHLKNYEIVSEHIPSR
VVLLAKKKFKKNGKWHTWINFKDTSKLLPTPTTGLSNKGTKDLIRQRKQDNKK
>A0A842UX57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MITREHRLLLKKQGYKLVGSHSAVKPCSWLRKSLFDKGVCYKEKFYGVKSHRCLQCTPSV
AWCKHSCLFCWRPLATTQEGIIPSEDDPLFIAEGMIKAQRELLSGYHKAEGVNEDKLAEA
QEPNQVALSLAGEPTTYSKLPGLVSEFKKRGATTFVVTNGTNPGALRKLDSLPTQLYMTL
PAPDKESYLRTCAPRVDSWTDIKESLGLFPDLATRRVIRLTLVKDLNMHDPESYAELIKE
SGTDWVEVKAFMSVGGARKRLPYNRMPLHSEIRAFSEELADCLGVKVLNEKQDSRVCLLG
LKDAHTL
>A0A2K6M760|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopithecus bieti|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQVVSKTQDRNLQEKSVPKAPQN
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYSSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKYCGGHCKKGKCESHQHDSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITAAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A7L4RHF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MGEGEGAIAIDGETIRRYENAHYGIAGRHSAVQICGWTRKSLRGQGVCYKQKFYGIDCHR
CAQMSPAFAFCQECCVHCWRPAEWMKKIKMGERETDPPQLIIDKIVEKRKLLVCGIGGAG
DADRKRFDESFKKFPSHWAISLSGEPTIYPKLGELIKLLRKNKEVRSIFLVTNGQEPQAL
AALKRRKALPTQLYVSISAPCEELFKKLNRSVYRDGWKRLQKTLAMLKTLGCRTVVRLTL
IRGVNDFDAHLREYATMLETSGPDFIEVKSYMHLGLSRERLERDNMAPHDYVKAWTRKLV
AVIPSYRTEDEDWASRIVLLKRKGSKFGNMIKNP
>I3D1S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosopumilus salaria BD31|TrEMBL
MSCSGETIEDDDRLIQIRPAISEQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMETEHVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLESTKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSFIRINKPKYDDSWERWNRTLDMLKNLNTRTVL
RITLIRNYNDQKEVIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKKFS
EQVAKQSKIFSIMDESIVSRISILQNNERFIDRWISTYTNTN
>A0A2H4VIV4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. MZ-A1|TrEMBL
MLLSDPAITSLEKKGYRFVGSKKHAAAKVCHWTKKSIMDDGVCYKEKFYGIESHRCLQMS
PSIPFCHHKCLFCWRDISITSTTWKDEFDDPGEIIDECIKAQRKLLVGYFGNPGANQKKI
SEAQDPTNAAISLAGEPLLYPPINQLLEEYKKRHFTTFLVSNGLSPDKLGKLNPEPTQLY
LSLDAPNPEIYKKICDPQVKDGWDNLNQSLDLLSSFNCRTVIRMTSVAGYNMTHPEEYAR
IIERSNPDFVEIKAYMYVGSSRDRLTFDNMPRSKDLESFAQEIASLCGREIVDKSSESRV
VLLS
>A0A674NW38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
LSGVFDFADYFMAIWHNRLYLYSTAALIFGIWFSLKMAIKKVHSNANSLAYKPVKKNDKD
SMVHVSGVKIFYGSQTGTAKGFAKELSDEIKALGIPAVVLDMKDYDPDDELAVECTNKSV
CVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTV
GKNVDKWLWMLSGKRIMTRAEGDCNVVKSRNGSVQADFLAWKVKLLKRLQALARGEKKIC
SGNCKTEGKCKNKRKVKGEENAALQNNSSESSSDEEESGLQEEKQSGTMLDMEDLGNIMN
LVNKTKSNENGRGKGQTVKLSKLNGLKKTEEEEDVREMITPALREALTKQGYKLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRW
KMDPAEKILQDALEKHQNMIRQFRGVPGVKLERYEEGLEVKHCALSLVGEPIMYPEINTF
VRLLHTHNISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDYWPRFL
DSLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASSLT
MANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQE
LVGVYEKTGGQRSFSALDYMAKTPNWAVFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A5E4JR41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MLPEKVQKSLEKQHYRIVGKNKHSAVQICQWTKKAIRGEDCCYKEKFYGIKSHRCCQMTP
SLWCPNQCLHCWRAIEFTTGEKIPGQIDSAKEIVDGCIEAQRNLLRGFKILPETRYKTRS
KANMKKWEEAQEPMQFAISLSGEPTIYPNLGELIKELRKRKKTSFLVTNGLYPEVLKKLE
KKKQLPTQVYVSVNAPNERLYDKFHRSTKKDAWKKLNETLEFLPRIRKKTRTVFRINLVK
DLNMSNELIPEYAQLIKKSRPQFIEIKGFMHVGFAKERLRYEQMPWHREVKDFAKKLSVE
LKRLKENYKILDEFEYSRVLVMGKDKKELKIKENEI
>A0A5E4LPD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MARTKGETGSGKYYSQTRSSNKSIPDAMLKLLMRQKYHVAGEHSAAKLCHWADLALKGHD
GCYKNKFYGIASHRCLQCTPCLLFCNHACVFCWRFMPEKKMKFEDVRVERFEWDAPEEIA
DWLISAQRKIISGYGGNKLVARSLYKEAMSPKHVAISLTGEPTMYPRLEELISEFHRRGM
TTFLVTNGTFPERVEKWKTYPTQFYVSMVAPNEKIYVPAIRPASPALWKKYRRTLALMPQ
IGKKTRTVLRMTLTRGINDSDLGGYAKQIKLAQPHYVEVKSMVFVGGARQEGRGLSPNSM
LEMDEVEKIAEELAGMTGYLVSEKHEPSRIALLCRDFEAEKNKMIKWL
>A0A2H9MIC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon CG01_land_8_20_14_3_00_37_9|TrEMBL
MDENLKKLLEKQQYRFSGNHSVVKICRWTKKSLVEGKVCYKEKWYPPVKSHRCMQMSPSL
VCNHRCLFCWRLHSGDRGFSWKESFEGLVLDEPKDILEKCIEQRKSLLTGFKGFERVDKR
KWEEALKPNMMAISLTGEPTMYPKLDELIQEAKRMNIISFLVTNGTLPDRLQSLNTKPFQ
LYVTLPAPNKETYKKLCQPSTPKLWDKIMETLELIDSFDCRKVIRLTLVKGLNMVEPEEY
AKLIEKANPDFVEAKGYVHVGESQKRLPMDAMPYHEDIIEFSKEIEKHSSFRIKDVFKPS
RVVLLKK
>A0A8C1STN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MCLVYCTVGAEMSGALKDVWDFTESYLLTVWQNRVYVYTTAAVLIGACFTVNMLFKKKKT
VDPVSPWLYKSARKQELSAETEKVILVSGVKVSYGSQTGTAKIFLNKYIYFKNSAQGIQC
EVIDMKEYDPEDRLAEEVMPLLCLFLRHPTESTEWFSKWLEEASTDFRYGKTYLKGMRYA
VFGLGNSVYVGHYNTISGCGSDKAACRPTSKGEKKACSGKCKKGSCKNKKKHKEEAEDSH
SLAEKNNSEASQPSSLMSLNTCSHGNGSRTRMEGDEEDSQRVKLSKQNGVRKSESEEERR
EMITPALRDALTKQGTARVIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRRMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQAAVENHRNMIRQFRGVPGVCPERFE
EGLTVKHCALSLVGEPIIFLVSNAQFPEEIRSLVPVTQLYVSIDASTKDSLKKIDRPLFK
DFWQRFLDSLRALGEKVGPLCCNPDETRKYIRFALGQPDFIEVKVLLYHLLSFLPLFFPV
CLQFKVDGEWWTWIDYECFQELIKGYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPS
DTRFQRKNKTKDISGC
>A0A1M3TSP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus luchuensis (strain CBS 106.47)|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKRSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPENRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLNYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAVEAQG
>A0A7H9HVB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Torulaspora sp. CBS 2947|TrEMBL
MHFNRVGALVALFCVAIYWFLGGRSSVALAGTVFCGIAYKEANTGENLSTEGNNSEAATP
KKKGCCGGKGGKNCCSSKGGEKKSGCCCSGKKAELKDKEVLPEPETSTEENFPDEIDFTN
AFKPSGKSKGANARPRKIISKPKVVFKPKNEDGLVKSAMTISKDALLSSQIYVFYSSLQG
AAQRAASTVHATLSKIEGLDLEPILLNLDELDDIDEYFVSVPSENALYFLVLPSYDTDCP
LDYFLQTLEENFNDFRIDKFPLRKLVGYGILGIGDSESWPEKFCYQAKIADHWIARLGGR
RIFPVGEVCMKSGGISDVQDWANLLSETLKDDEPILYEYDETVDEDEQDDNDQVGDLEDI
GKESNGDGSEIKQMVAENSPTYKKLTKQGYVIVGSHSGVKICRWTKSDLRGTGSCYKHSL
FNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDPPEYILENALKGHYSKIKQ
MRGVPGVVMERFAKAFQVRHCALSLVGEPIMYPYINKFVELLHEKEISSFLVCNAQHPDA
LESIGKVTQLYVSIDASTKQELKRVDRPLYKDFWERMLSCLDILRTKQSHQRTVFRLTLV
KGFNMADISSYADLVQRGLPSFIEVKGATFAGSSDGNGNPLTMQNIPFYEECTNFVKQFA
AELQRRNLGYDIAAEHAHSNCILIASTKFKINDEWYTHIDFDRFFELLNSGQDFNPMDYI
AKTPEWALFGNGGFAPGDTRVYRKGKKKSKDVPKGESTA
>A0A7C2L0S5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MRCGLYSDDLVAGFLGSAPAGSVEVAKAELARLRRVGYRVVGRHSAVKICHWTRSVLRGG
KNCYKGWYGIRSHRCLQMTPSLQYCNMMCIFCWRHHTINRVTGVGGEWDRPEDILDGLIR
EQRQLLSGFKGNPIVDRKLFDEAMEPRHVAISLDGEPTIYPYLADMVKLVKSRGMTAFLV
TNGTNPDRLMELVEENAEPTNLYISLYGPDPETHRMLCRPLIPDSWERLMRSLRVMREFQ
KSVKVVRLIMINDYTIQDPEKYAELIRIGEPDFIECKGYMHVGESQKRMRREAMPSLHEI
RPFAMKLADALGYEYLAEDRPSRVSLIANPSSPHYDVVRMRVSGPGTGF
>C9RIB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus vulcanius (strain ATCC 700851 / DSM 12094 / M7)|TrEMBL
MISEEIFRILRKQRYQIDNHTAVKLCGWVRKKMLEDKNCYKSKFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPQDINIGLKDANLKEPNWEEPEIVFEKIINMHRRIIMGYKGVLDRVG
EKKFEEALNPKHVAISLSGEPTLYPYLDELIQIFHKKGFTTFVVSNGILTEIIEKIDPTQ
LYISLDAYDLESYRKICGGKREYWESILNTLDILKEKKRTCIRTTLIRGFNDDILKFVEL
YERANAHFIELKSYMHVGYSQRRLKKDNMLEHSEIIKLARELDEGSDYVFIDDSEESRVA
LLQNRNRKIDPKIKK
>A0A1G4K565|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea sp. CBS 6924|TrEMBL
MGFLKDLDDHLLILSVAATYVLSGGRFTLGLAVLVVYGLIRYDTARNEKNSKMVDSETSE
NADVKKKKKTCCGGKGGGCCSSKSSEKKGGCCGGNCSSKKKSSEKVEEVTSDTTPAATEV
EELAIDFTEAFKPVKKSKKARKIVKSTKPEPKNKSEFFKKALTVSNETLISSQIYVFYSS
LQGAAERSAKVVTDVLSDIKGLKHVPKLMNLDELSDFDDYFVNVPCNNALYVMVLPSYET
DSPLDFFLQSMDENVNDFRIDRLSLRKLVGYCVLGIGDSESWPEKFCYQAQQADLLLAKQ
GGRRVFPVGEICMKFGGDPSVMEWAKLLADTLRDDEPILYEYDESLETENAEEPSDELTK
ESLVDLEDVGASSELQDVTQIKEMVAKNSPTYKNLTKQGYTVVGSHSGVKICRWTKNDLR
GRGSCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDDPEYILENA
LKGHYSKIKQMRGVPGVIAERFAKAFEVRHCALSLVGEPIMYPFINKFVSLLHEKKISSF
LVCNAQHPQPLRDLGKVTQLYVSIDAPSKSELKKIDRPLYRDFWERMLECLEILKTSQSH
QRTVFRMTLVKGFNMSEVNAYADLVQRGLPCFIEVKGATFCGSSDGNGNPLTMQNIPFYE
ECANFVKALSAELQKRGLGYDVAAEHAHSNCILIADTKFKIDGEWWTHIDFDRFFELLES
GKPFDHTEYIAKTPEWALFGNGGFAPGNTRFYKKKKSTETKSEDPKDDTKMTRPIAA
>U6EC35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. MB1|TrEMBL
MPLSDQNIKTLEKKGYRFVGSHTHSAAKVCHWTKKSIMDDGVCYKEKFYGIKSHRCLQMS
PSIPFCQHKCLFCWRDVDVTSTSWTEDYDDPGQIIDECIAAQRKLLVGFFGNPHANQEKV
LEAQDPTNAAISLAGEPLLYPSINQLLEEYAKRNFTTFLVSNGLSPEKLGNLNPEPTQLY
LSLDAPNRKVYQKICNPQIPDGWEKLNHSLELLSSFNCRTVIRMTCVAGHNMIHPEEYAR
IIEKTNPDFVEIKAYMYVGSSRERLKFENMPRSKEILSFAQKIASLCGREIVDHSLESRV
VLLA
>A0A8C6LM77|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
CLCTKLQLRLPTLEMESWPKWLGRGKSGPPCLGCCPRGPCLFLKVCPVFVFLLLPSAAIF
NMISSQCVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGLRYAVFGL
GNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAWKVNLLSR
LQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVTCPFSACFREGGRGTSQMVKMN
GGKKTEDDGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFR
GVPGVKAERYEEGLEVKHCALSLVGEPIMYPEINTFIRLLHRHRISSFLVTNAQFPEEIR
NLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWN
VEEMMAYAELITLGQPDFIEVKGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPRY
EIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTP
SWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A8G1M4S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salinarchaeum sp. IM2453|TrEMBL
MGTGDGTGQLTNPEYHNVNHTAVQPCGWTKNALNNEGTCYKSKFYGIHSHRCIQMTPVVR
CNERCVFCWREHSGHAYELDGVEWDDPEAVVDASIELQKKLLSGFGGNDAVDEATFEEAM
DPKHVAISLDGEPTLYPYLPELIQEYHERGITTFLVSNGTRPEIIKRCDPTQLYLSVDAP
TREVYNDVVKPMDDNAWDTLMESLDIMGRTDSRTTIRTTLVGGHNDKNFDEYAELYRRAD
PDFVELKAYMHVGHSRDRLDRSTMPDHDDVIEFAQEMQKRLPEYGVLKDSPPSRVVMISK
EKNTHYSFEEG
>A0A2P9B9W1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium sp. gorilla clade G1|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKDKISNYENMVPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGHLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTVGND
EKDIVNEHKTKVDKTNGMTNEKREEVYVRVDIQGVEGCTNCNCQSVNEYNDTSNTNDTNN
TNNTNIMNNTNNTNNTNIMNNTNNTNIMNYTNNIRTGENCVSESETSSNQSYPDDEDEQI
EVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGI
NSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKG
IYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPQELEN
LNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNM
MENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINKKKA
LSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVETPH
WAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A6V7RZA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vinckei lentum|TrEMBL
MVTKREDELVPPLNEGGNVNIYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIVFFND
ILNHFNTISTITKGDKTNGTIFDGSISNEINSIEDYMLEYFQSKLLKTNKKNKDRKFGKN
CKNEKENITNNESSECDNEVKDIFNNLKKYEKNMIKCGNTHFNNYLNCSIENNISEIHFD
FVNGNEFDSYTFFENSENNDLNILFMFISTYNFGSFPANCYKLEDTLTDLVNDFRVEKNY
LKNIFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLKLCSTMDNEEEFVHWK
SSLLKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKGDDAKSMSINNDE
NKQTNKPVNNNNINKYDCINNSMPSEHLNTLKESGNDHISFSTSKIDASNTEKCGCTSNN
CLNGNDKYINEKKIISSNFETSIVNGCYKNEYEQDDELINSDFSNESISENNDEINCNSS
EDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQIRGRGGCYKHTFYG
INSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKELK
GVHNVISERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNELK
KLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKEKKERTVFRFTLVKEYN
MMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSKR
SISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNFTAIDYCAETP
EWAVVGAPECGFNPSDQRVYTKGKNKKKNNINTMEVKT
>A0A7K4D434|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MDSIEAKKTLAKQGYHLVGSGAVKPCLWLNRSMRGGDQCYKHHFYGISSHRCVQMTPTLR
CNHLCLHCWRPIDSVLPKEEPMEPAALLDGILHEQQRILSGYGGAKTTDKSRLKEALEPK
HVAISLMGEPTIYPYLQELIDLISKRGMTSFLVSNGTNPEVLESIRPTQLYISLNAPDEG
MYRRISQPSGSFWPKIQESLSILKNHNCRSVVRMTVARGLNMERPKDYARLLGSAEPDFV
EVKAYMHLGRSRTRLDREAMPDHAEVLSFARALGNAMGYDLSMDVPLSRVALLSSGRICK
SLDS
>A0A6G1RI55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypotaenidia okinawae|TrEMBL
PSGGGDLDVSMDTWSFFHTCLVSVWLHRFYIYSAAAFGISIWIIAQFFTTKNKGGKPSGH
PAAPEGTGDKLVNGYATLRAKEVCVAGVKIFYGSQTGTAKRFAKALSEAVISLHLPVEVI
SLGDSDPDDRLAEETTSGNICVFLVATYTDGQPTESAAWFCRWLEEAANDFRCGKMYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLGARRIMTRAEGDCNVAQSKHGSIEADFEA
WTAKFLSQLQALCRGEKQPCSGKCKSKKCKSLGKQSKESSDHDHGASECENTEAEELFET
SSEEEAGAEEAGGTSSVIDVEDLGRIVSHVRRAKRDPEAGGAGTSSTQENEGRKEEGEKR
EMITLALREALTKQGYRLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPS
LACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFAE
AMAVRHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSV
DASTRESLRRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIA
LGQPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLLPDYDIACEHEHSNCL
LIAHRKFKIEGEWWTWINYSRFQELVQERESSGGSKTFTAADYTAKTPHWALFGSRERGF
DPLDIRYQRKNKARDISGC
>A0A7K9RSR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sterrhoptilus dennistouni|TrEMBL
LDVSMDSWSYFHACLVSIWLHRFYIYSAVAFGISLWAVVQFTTARTQKKVTEPGTADKLG
NGCVPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLSLPVEVINMGDYDPEDGLV
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTRLQGL
CKGEKKPCSGKCKKGKCKSSGKHSKESSDHEHGTSEHENTEAEEFFETSSEEEAGGTDSV
IDVEDLGTIMGHMTKAKVLLLAGSIGSVASVTLGTTWYIFVYQFLQTKLNCLMICASFSG
YKLIGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEAIEEHRNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTRESLRRIDRPL
FKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYC
GESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRT
WIDYRRFQELVREYERSGGSRTFTAAEYTARTPPWALFGARERGFDPSDVRFQRKNKARD
ISGC
>A0A081A0S5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora parasitica P1976|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A093ZYJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4281|TrEMBL
MANNDYPGADIASDAMENYVMALWHTYRIPIILTAFALLFITRTVLHLKVGREKIIYTPP
PTPTEKAAPIVAANPQREQLVEKAPISAEVKKTGPKRVVGKVTRKKSPLRDQDQPASKDV
KFQVLVFYSTLAGSTERTAQAFTSKLADTLKARAESSQYEFLSPIAHDLAELEDYDEYFL
GLPKPEEGGPDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFG
FGDREGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLDEWRQGIEDV
LQNLGQTGNLGEGVVGSGDADESDVEEADDDDTEVQSDGAVKLKRKSKKKVTSSMDDVED
IGRILQKGQAESEDQDEGAIDFTTYGKKTAKPVAAPKEMVPKGSPTYNALTKQGYTIVGS
HSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYL
NEFTAMLHKERISSFLVCNAQHPDQLATLKPVTQLYVSIDATNRESLRKIDRPLHRDFWE
RFQRCLEILREKRNEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTS
SSGAAGLTMQNVPFYEEVCAFVLALTAALDRRGLKYGIAAEHAHSCCILIASERFKREGK
WHTRIDYEKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRV
EEAGAEVPEEKRLLVEI
>I1CSV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)|TrEMBL
MSNFINSLLYNFTNILSVGPEPPREGEEEQCGSGCCREQPKNDSGCCGGNTDRDGCCKTN
QQDITEIESIKVFYSSLTGTAKNFAQELQTKLEQSDLIKINKLEIMDITEYDNDNLLSET
SVCIFLLSTYNVEGPLDWFSNWLHDLRYDFRVDRDVLKKLRYAVCGLGDSAYGEDFNVAS
ANIDKWLGRLGATRIYPLGECDKNADQKAQFDLWSNRFISELQDKHTLEFSPANIAFQSE
DEEEEEEEGSEVGIESSEDEMLDLEDMGKMASKIKAAKARRAEEEEDFENSKARAKQTIG
EKTRNKPEAREMVSPMIHKNLTKQGYKVVGTHSGVKICRWTKSALRGRGFCYKHAFYGIQ
SHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLKGV
PGVKADRFQEAFTIRHCALSLVGEPIFYPHINDFVTMLHERNISSFLVTNAQFPDKIAEM
VPVTQLYVSVDAATKDSLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNTE
EIDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIEFCRKLTSKLDGEYE
ISAEHAHSCSLLIAHKNFKVNGEWHTHIDYPKFFELVKSGKPFTSLDYMAKTPDWAIHGH
EAAGFDPNETRFYRKNRKTVVPPTINAEA
>A0A3Q0HK57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alligator sinensis|TrEMBL
MDLRGNLQLHKSRQDASVDTWSYFYTHLMSLWLHRFYIYSCAAFGISIWICIQFFAGRTK
KQDGKASWKPASLEVTDDVLVNGYATPKAKEAYVAGVKIFYGSQTGTAKGFAAVLAEAVV
ALTLPAEIINMREYDPDDCLAEETISKNVCVFLVATYTEGQPTENAAWFCKWLEEAANDF
RFGKTYLKGMRYAVFGLGNSVYIDHYNTVGKNIDKWLWMLGANRVMTRAEGDCNVAKSKH
GSIEADFAAWRVRFLLRLQALCKGEKKSCSGNCKKGKCKSKVKQSKEGSDHEQRVSEQEN
TEVEELFETTSEEESGAEEDGDANSVIDVEDLGKLMGHMKKAKKEHELDERAGRMDRSLR
TIGKKEGSEQREMITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKLDQPEMILQEAIENHQSLIKQFRG
VPGVKADRFEEAMVAKHCALSLVGEPIMYPEINRFLKLLHGHHISSFLVTNAQFPEEIRN
LEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNV
DELKAYAQLVSLGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELAELLPDYE
IACEHEHSNCLLIAHQKFKIHGEWYTWIDYDRFQELVQNYDESGGSKTFTVADYMARTPC
WAVFGSRERGFDPLDTRYQRKNKKDISGC
>A0A842QLN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MDKKLESRLKKQHYYLAGNHSAVKICTWTKKSLKDEGACYKEKFYGIKSHRCCQMTPSFM
CDLECIFCWRNMEAHTGIKMEGRIDEPHEIIDKCVEGQRKLLNGFPGNEKINIKKFREAQ
NPNQWAISLTGEPTIYPKLNELIKLLKKRRDSVFVVSNGMFPERLKNIEPPTNLYLSLDA
PNKELFEKIDKPTQKNAWQKLNKSLEILKELKKKTTTVIRITLIKGMNDTDIKGYAPLIK
KAEPNFVEVKSFMFVGSARLRLSMANMCRHEYVKEFAKKLSNISGYEIKDESVESRVCLL
KRAKGEILRRLYE
>A0A7J4LFC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MPQQTRQLISEEQLRYYEKEGYRRVGNHSAVKVCEWTKKSIRGQDVCYKCQFYGIHSWQC
VQMSPTFFCDHRCVFCWRDIKYVFPKWQGPIDEPKDIIDGAIKAQIDYLQGFWGNEKAVK
EKLEQAETPMHFAISLTGEPTMYPRLHEMIDELRKRNISSFLVTNGTLPEMVEKLTEHQP
TQIYFSVYGPDKETYIKTANPLPQDAWERLHKSLSFAKKFKRSVIRLTLTKGYNFTDPAG
YARIISFAQPTFVELKGYMWVGHSRERLEPNNMPYWNELESFADAICMHTGYKIVDKKEI
SKVILLAKEEFDGRIMNFDV
>A0A7J4LCN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MLTEKKRLELENQGYRIVGNHSAVKICGWTKNALRSRGMCYKNTFYGIQSWRCVQMTPAL
QHCNFRCWHCWRDIATASREWTGPVDEPKEIVDGCIREHLGLLMGFRGNPNANMKRIEEM
KVPLHFAISLTGEPTMYPRLPELIDEIQGRGMTAYLVTNGSYPEMVEKIIGHEPTQFYIT
LAAPTEEMFIKTTNPLTKHAWERFNKTLQLMEKMKCRRVLRLTLTKGHNMYNPEEYGKFI
KNLHFDFVECKGYVHVGYARYRNTRDNMPTHDEIKEFAAKVAEAAGLKYIDEKPESSVVL
LMKEDRPDRILDFEAELRNEVELPDILDSKPGGLPILNSNSMPKNSGLKIIQESGCGDNC
NC
>A0A662FAE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MYIAKDIIAQLEKKQYAVSGHSGVQICTWNKKALQGRGVCYKQIFYGVHTHRCMQFSPAA
VWCSNSCIYCWRPMELMSFTEFKNEVAEPPHKIVTSLIELRKRLLSGFGGRVGTERRLWQ
ESLDPDHFAVSLSGEPCIYPHLPQLIKHLKLDRHARSVFLVTNGTFPAMLERLAKEGGLP
DQLYLSVVAHEPELYKRIANPKASHNWEHFLRSAQLLHNLPTRTIVRFTLIRGWNDAKKE
MRKLAHFLENIGADFIEIKGYMFLGYSRRRLNMENMPLHSEVSSFSQELCALMGLYEIID
EHPPSRIVLLRNKKTRKSESLFPLEEPNQGTEEAKKAASE
>A0A662FFH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MIPDELRKVLEKQQYAFIGRHSAIKICYWTKKSLLDEGVCYKQQFYGIKSHRCCQMSPSI
GFCPNRCIFCWRPIEYTIGSVLPDKNVDDPDELIKNAIAMQRRQLIGFKGNPKTNMKKFA
EAMEPMHFAISLAGEPTAYPKLAELIEKLHGLGKTTFVVSNGMFPDRLAEINPTQLYVSI
SAPNEELFKKISQPQLRNGWDLLMKSLNVLRQKRDKTRTTLRITLIKGWNMVEPENYAEL
IKLAKPLFVEVKAYMHVGFSSYRLSPTNMPFHQDVKEFAELISAESGYRFIDENSASRVV
LLMEKDFEGRIMRFE
>A0A8J8IYG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. MV5|TrEMBL
MDVKPNMPEEIANLFKKQHYALVGHHSSVKLCHWLKESIKHDRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPGPLDDPAFIVEESIKAQRKLLSGYWGIKDQIN
VKKLEEAMEPRHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEPEVLEKMFNEN
KLPKQLYVSLTAPDEETYQKVNVPMIPDGWDRINRTLELMRELPVRTVIRLTLVKGENMH
NPEGYAKLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHDDIKAFAEELVKYLTGYHIE
DEYPPSRVVLIMRDDVSKADRVIKH
>M7P519|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pneumocystis murina (strain B123)|TrEMBL
MFLLLYQLWKSYRVFIAICLILIYTLYFLILYFQQKTSLIDKKLSILSNSSKGNDVICSK
DDKNDFNTEISKSVKIRTPKRFIRSLAKYPKALNVDENTRQSFVENNRQAIVDVNDIYVS
ILYQTLLGSTEKYAKLLYDIISPHFEKQVLLENIDFVEDFDDYFVSPENPESRIFIFLIP
SYETDSPVDLLLSTLKDILYDFRVGAIPLRNLKGYAVLGFGDENEWPGQKFCYQAKDLDQ
YMFKLGARRIVSVGCGNVKGDITNDIQAWANVLLNAIKNGTMPELISDVSEESENEPFED
NEDSVVDMEDMGMLMKTKKTEPGELKPKEMVSKSSPTYKSLVKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKYSFYGIRSHLCMETTPSLACANKCVFCWRGHTNPVGTSWRWKIDKPE
DILFGMMEGHYNKIKQMKGIPGIRPERLKEAMRIRHCALSLVGEPITYPHINELIKMLHD
RKISTFLVTNAQHPDALENIGQVTQLYVSIDASTKDSLKKIDRPLFKDFWERFISCLEIL
SRKQQRTVYRLTLVKGFNTEEVEQYAHLVSVGKPCFIEIKGVTYCGNTHSSLTMKNVPFH
EEVVGFVKALTKKISEMDNVPEYDIASEHVHSCCVLIAQKKFYINDKWYTHINYDRFFEL
AESNMPFSEMDYISETPHWAYFNSPYGGFSPDDIRWKRKNAKNVNFKREEIGLQNNTEY
>C3NHS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSVYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A4W3IQP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callorhinchus milii|TrEMBL
PFTIFPQVGFANTLLDAVKLLGLPVEVVDLKEYDPDDNLIVSKTVCIFLLATYTDGKPTE
SAAWFCKWLEEATNDFRYGKNYLKGLRYAVFGLGNSAYVGHYNTVGKHVDKWLWMLSAGR
VLTRGEGDGNVVKSKRGSLEADFSAWQVKLLSRLEALGQGDRKECSGNCKNGKCKSKGKK
HKDESRQKEAVPNERLEHSEEEELFETSSEEGSGSDSETGARSVVDVEDLGKVMNSMKRA
KVTGCYYRDDNICCLLYLGQSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWRWKMDEAEQILKEAIENHQNMIKQFKGVPGVKAERFEEGLAVKHCALSLV
GEPIMYPQINHFLKLLHQQRISSFLVTNAQFPEEIRNLVPVTQLYVSVDASTQDSLKKID
RPLFKDFWPRFLACLQGLADKKQRTVYRLTLVKAWNVDELKAYSDLIDVGKPDFIEVKGV
TYCGDSSASSLTMANVPWHQEVVHFVQQLADLLTDYEIACEHEHSNCLLIAHRKFKVNGE
WWTWIDYERFQDLIAGYEESAGARTFSSEDYMAKTPLWALFGAKERGFDPTDVRFLRRKQ
KDISGC
>A0A7J6C9V8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Onychostoma macrolepis|TrEMBL
MLFLAVVSCLLYCTVSAEKPGALNDVWDFTESYLLTVWQNRLYVYTTAAVLIGVWFTVNM
LFKKKKMVDPISPLLYKSVKKQELSTETEKVIHVSGVKVFYGSQTGTAKGFAKELAGDVV
AQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKNGSCKNKKKHKEEAEDSQSLAEKNNS
EEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQFRG
VPGVRPERFEEGLAVKHCALSLVGEPIMYPEINSFLRLLHQQKISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFMDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYE
IACEHEHSNCLLLAHHKFKVEGEWWTWIDYKRFQELIQEYEESGGTKIFSAMDYMAKTPS
WAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A2V4HGT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasma sp. Kam2015|TrEMBL
MQNLYADIYRKEHYGLVGNHSAVKVCHWTKDELLGGPGCYKNTFYGIKSHQCIQMTPALN
ACTENCAFCWRFQGFDSMHISNEDDPEYILEESIKQHLKLISGFKGNPKVSKEIWEEATH
PKHMAISLTGEPTLYSRLGELIAAAKKRGISTFLVTNGTLPSVLERLDPLPTQLYVTVAA
PNKKIFNELLNPSIGNGWENLMRTLELLPSLDTRIVIRHTLVHGVNMPYLDEYEMLDKKA
DPDFIEAKGYVHVGSSMTKLMASNMPSHTEILEFSHDLADRMGYTFVADRVESRVAMIAK
DPSKAKIDFSSV
>A0A0D1XH20|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala sideris|TrEMBL
MDLGEGGEALVILADWLDQLLNSWHDYRIGVSTILVLCFLILVWQRRRSHTLHIRNSSPG
LEKATWLDRDEKKPHEKATRTESPSEEVSKPTAGETRKSRPSAPRVVTGRKPTATKSRSG
GHQEAEFSSIQPLVFFTSLTGTTERLSNTVLAGLDKLAATQSVVLKPEIHDLSYIDLDDY
FISGPKTPAPRPDVRYVYLLLIPSYDIDTILTTFLSHLDETHNDFRIDTASMSSLAGYTV
FGVGDKEGWPTEEKGFCSQAVEVDMWMAKLTGRKRAYPLGLGDVKNNVDQALRDWTAGLC
AVLEELGTTGTLGEGVPGSGDADESDGEDLEQADDAEGDFPDSGRNKRRKLASTTDLEDV
GGKGAPMAIDFTTYSTTAPSAPVALKAMVPKESPTHAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQMI
FDGAKEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFLGMLHAEQ
ISSFLVCNAQHPQQLQDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQACLDILRE
KRFVQRTVYRLTLVKGFNVDDEVEGYADLVEKGLPCFVEVKGVTFCGSSTSAGAGLTMQN
VPFYEEVVAFVEALDKALKKRGLEYGIAAEHAHSCCILLASKRFFINEKWHTIIDYDRFF
GLLEQGVEFAPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEVKKVVVQAVPEEKSQL
DF
>A0A1Q7KA43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_3_50_5|TrEMBL
MSCSDEHVSHSTDNLIQITPQLKARLQKAKYGVYNHSAVELCHWTRKSFANEGNCYKHKF
YGISTHQCMEMTPAAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDVIVEQLMAERKKLI
NGYYGNTKNDKRKLDESLLPAHYAISLSGEPTMYPKLPKLIKYLKSLKATKSIFLVTNGQ
EPDMLRRLTAEDALPTQIYLSTNASNKKMFHQINRPLHKDAWERWWESLRFLATVNTRTV
LRMTLIRGYNDSKNFVGEFGEMMAKGNPHFIELKSYMHIGMSNRRLEQDHMLEMQEVRDF
AVQLCEKMSPFKMMDESEVSRIVVLQNQARYTDRWIKEYIMPAS
>A0A7C8IL61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xylaria multiplex|TrEMBL
MASNLTTDWGGSQSPGDFLEFWHTHREVILVVVICFSSTAWILYSTLPTRRVIKQPPTHS
VATAKLAPTKPVVLNTENLEAPVEALPQDAVAHGPRRIKGELRKPEATRKVSSFEGSRRT
QVLIFYSSLTTTTEKIANDFARNLSASLEGDAERKDLFCDPSVLDLAQIDYDEYFINPPK
PVDSTTPVEYFYLLLIPSYNIDTINDNLLEHLQETHHDFRIDTAPLSGLLGYSVFGLGDR
EGWPTEEEGFCFQAKEVDRWMAKLTGRKRAYPLGMGDKKQDLKNRLGEWAEGMTDVLKLA
ATTGSLGEGVPGSGDADESDFEYASGEDDDEVVVEESATLKKKKKNNNKKTTNIDDVEDL
GRIMKSNQASPNDSKGPTPIAIDFTTYKKSNAKKAVAQTVKEMVPKSSPTYTSLTKQGYS
IVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNP
VGTTWRWVVDPPEMIFEGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIF
YPHINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHR
DFWERFQRCLDILREKRFKHRTVFRLTLVKGFNIEDEVEGYADLVERGLPCFVEIKGVTY
CGTSTSAGAGLSMANVPFYAEVTEFVTALNKKLNERGLDYGLAAEHAHSCCVLIASGRFR
VDGKWHTRIDYTRFFELLEERGADGDWKPEDYMGPETPEWATWGKGGFDPRDERVDRKGR
KIEVS
>A0A0B2WXQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium album (strain ARSEF 1941)|TrEMBL
MSAVCEKADPLEGIFGWPPGSRFSDIVELWHGHRTPIILCALVLLVVFRIYVHNFEEAGS
LKKLPKRYEKEIEPSSANKQPNVSSFETPIVKPNGPRRIKGGIAKKPAAQENEEPDKSRP
IKTMVFFSSVTTKTDKIARQYINTLGQSVDQLSRETERRFLKPELHDLSEIDFEDFFVSP
AKTVENAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLASLLGYSVFGFGDKE
GWPNEADGYCFQATELDKWMSKLTGRKRAYPVGMGDMKSDHSKRFKEWTWGVQEAIAHVA
STGSLGEGVPGSGDAIESDAEDAAEEDDGALLIEGDVSSGDKEFSRPLDDVEDLGRMIRT
ADSDGKKAPPPVDFTSHGSPSTKERRPTAPVIKEMVAKNSPTYAALTKQGYSIVGSHSGV
KICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWV
VDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPHINEFL
AMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQR
CLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTSTSSN
AGLSMSNVPFYWEVCEFVKALEQRLQAKGLQYGIAAEHAHSCCVLLASERFLVSGRWHTH
IDYERFFELLEERGPDGDWTPEDYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIENVVVR
EAPPPESW
>A0A842XSM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNGTIQHLEKQQYRIVEETGAVKLCHWMRQRLIYGRSCYKEEFYGINTHRCLQMTPAVNI
CNFRCLFCWRFHGMTGFEDTKYPEPEELLERCLQEQRSLVSGFKGDERCDPKLWEESRHP
NQVAISLSGEPTLYPHLGEFIALCKRKGMTTFLVTNGSIPKALANLSSLPSQLYVTVAAP
NKELFKRVCVPQFDGAWENLMETLELLPSLSTRTVIRHTLVRDWNLGWEDEYARLDEIAS
PTFIESKGYVFVGDSRTRMTIENMPSHSSVVEFSRRIADRLSLDILAEREDSRVTLIGKK
GSKLKIAE
>A0A0E3LRG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina barkeri 227|TrEMBL
MRKMPLEENKENAGENFPEAQNKNRKEDTASLPFDIPDFKTLLKKQGYALAGRHSAVKTC
LWLRHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPE
KIVEESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIKEYEK
RGFTTFLVTNGTVPEMFAKVSPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSLMK
QKKSRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSQELAKHLGYEVADESEISRVVLLSKDGRKSPVNGKKISC
>A0A6P7WEC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microcaecilia unicolor|TrEMBL
MDAPVEISDYLYAYFMSFWINRFYIYSCAAFVVGIWIFLQFITIKKKKQDESPYQNGVVQ
YGGEDVHSTQKEKETHISGVKIFYGSQTGTAKGFATSLAKEIISLGFLAEVLDMKDVDPD
DSLIEQTTSKNVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRVGRTYLKGMRYAVFGL
GNSVYVNHYNTVGKNIDKWLWMLSASRIMTRAEGDCNVVKSKHGSIEADFDSWKSKFLSQ
LQMLCKGEKKSCGGKCKKTNCKSKKKKTGEGLDHDQQALGESEHDNTEEELFETTSEEES
GAEEREGTGSVIDVEDLGKMMGHMKKAKKERELAERSGKVGPFQEKNGMGEDGEAREMIT
PALRDALNKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNLIRQFKGVPGVKADRFEEGLSV
KHCALSLVGEPIMYPEINRFIKLLHQHRISSFLVTNAQFPQEIRILEPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALADKQQRTVYRLTLVKAWNVDELKAYADLVSIGKP
DFIEVKGVTYCGESTASNLTMANVPWHEEVIHFVQELTNILPDYEIACEHEHSNCLLIAQ
KKAQCGLHYAAMAITINGMRSTEYYS
>A0A812SUZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium natans|TrEMBL
MFVTEYAVKHRDQRGKLPGNGHLSVIEFKNGLRQVLDPDSIETLVDSLDMDHSGSVDYSE
FVAGCLDAHMGLIESALYHAFHVFDVNNDGVISLGELRSILKDGGEALSVVLPEGKTVEG
FMKDIDTSKDGFISFEELKEFLKKEADASPCARPPKKEAARRLSSAGIGPNSSMSTAPSA
GVASQRPPAPVPVEPELYAQLQRCVDLSSSNVGLLKELTLSPARWSPTSLAKVRALRVKE
RSADDAWVKRLRQERVRPLYHAGELKSVHLELTTRCNAACPQCPRNLQGGAENPVLAAHH
AELSLADVRAILPPGFLRQLRKVYLCGNFGDPAVAEDCREVLRYLLSVDGPRIGLFTNGG
MRSPSWWQELGSIMQPAARAFVRFAIDGDASTNHLYRQHVKWERLMANVDAFLGAGGNAE
WDFIVFEHNEHQVEAMRSLAEQKGFTKFNAKKTARFIDKAQGVVKPSVPVRNLAGEEVRK
LRPPSRTWQNEAALEGVQKAVEKYGSIESYYDRCEISCKVAKEKEVYISADGLAFPCCWL
AAEMYRSDLPNTGREVVRLAKAAFPQEGLSALSARRRGVAGAVDRRAGLFQQLVPAAMQQ
PSLEAGRLRTCSAVCGAEVNAFVKQFEGAAKALDPGLRTATAATTAPFRASAEAAPVEVW
YGSETGNAERLALRAAEALGAVAAVSAPPRSDEVEGRLRSCQALVLVLATWGQGEPTDDA
RGLFQWLREAKDAGSSLALPVAIFGVGSSLWPDFNAAARRAGELLGALGVPLLALGEGDV
ADARSLDSQFESWLQQRLLPALGARGLGAREGPALVRRDAGAESSSVQLTVTRVARLAPS
DPVARYFEVELAGAHGALPHGPGDALGVLPPGGRGLGARPRWYTISSSPGVLPSSGPGQV
LRLMVREVPTGGCSPWLCGLRAGDTVECLPPRRPSPLRAAWEARRATRLLLVANGAGLAP
FLALFEKLAAESPECRPPAWLWVGCRRREGGLPHQERLAALEAEGVLRRLAVAESNPTSS
DAPRCWVQDVLRAEAEEVGQLLFGSGEPTALMLVCGSAAMGCAVRDVVSGIAAARGTSVE
ALDCPKLAVFQSSCAEQVQGTHSIKVGEGTVIHPACILHAQAGPIVIGRFNVLEEQVEVV
NSSDQPLVIGDHNILEVGARILGGGGARLGDANLVEIRATLDEGCSVGSGCTLGACTSLK
EGEAPLADEMVVIGPGVRHAEPGAKEAHVQAVLKYIEVLKETLPRCHHLRKSNVKP
>A0A7J4SEI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MEPAIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSETINKVTSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDVCHQHGVSTFLVTNGSLPKVIERLDTLPTQLYVSVDAP
NRDIFNRLCKPKFDDHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDVMSFSNTLAPLVGREVLSDRRESRVSLIGK
EMIPVTLPEKTRDLPANLGIAKPQNFKLPSF
>A0A7J4U0K7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MEPRIAAKLAKQRYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIESLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGHHEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSQELAPLVDREVLSERRESRVALIGR
EMIPVKLPEKIRDLPKDLGIAKPQNLSLPTL
>A0A7J4N7B5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon|TrEMBL
MKDDLRKILQKQQYRLCGDHAGVKLCHWMKQSLLKGRTCYKQDFYGIRSHRCLQMTPVVN
DCTHNCLFCWRVRGFESTVTKWQDPETVLDTCVEGQRQLVTGFKGDPRCSPAMWEEARDP
RQVAISLAGEPTIYPYLGDLIELCHRRGMTTFLVTNGTFPKVLEGLSELPTQLYVTVAAP
NKDIYRKLCVPRVDDGWERLMETLELLPSLNTRTVIRHTLVKDWNLGWEKEYAALDRKAD
PTFVEPKGFVFVGDSRRRMSMDNMPSHAEVLEFGRRVADELGLCMLREKSDSRVAVFGES
GTETKIPGLDQSG
>A0A8J7P377|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Atractosteus spatula|TrEMBL
DNWKDGWGYFHSCFMSAWQNRFFVYSVAAVCIAVWFTFQMVTKKENKGVSSTLAQNPKNK
KEKGIVAEKVNKVYVSGVKIFYGSQTGTAKGFAEDLSIDVQSLGLPSEVIDVKDYDPDDS
LAEEATSKSVCVFLFATYTDGKPTENALWFCKWLEETSTDFRYGNTYLKGMRYAVFGLGN
SVYSSHYNTVCKNMDKWLWMLSASRIMTRGEGDCNVVKSRHGSIEADFAAWKSRFLTRLQ
SLAKGEKKSCGKKCKSGRCKNKKKHQQPAEEESESSPGKEEHSSEEELFETSSEEDFTQD
EVATHGPVIDVEDLGQVMNQVKKAKKRGEMEEDPGKVMLSKQSTGRSDDEEAREMITPAL
RAALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDPPEKILKEAVENHQNMIRQFRGVPGVMADRYEEGMMVKHC
ALSLVGEPIMYPEINRFLKLLHRHRISSFLVTNAQFPEEIRSLEPVTQLYVSLDASTKDS
LKKIDRPLFKDFWQRFQDSLKALGEKQQRTVYRLTLVKAWNVDELKAYAELVALGKPDFI
EVKGVTYCGESSASNLTMANVPWHEEVTHFVQQLADQLPDYEIASEHEHSNCLLLAHIKF
KVAGEWWTWIDYERFQELVGEYEESGGANTFTALDYVAKTPRWAVFGAKERGSCSDCDRE
EKEQESSDSCVLKMEVTGTSREGDSEGPCTLCDMMETRTGQPVLLQCPLEYDPYGEKMPF
HHVTAGLLYKGNYLSRSLSDGSDSEQLANISVEELDEIREAFRVLDRDGNGFISKQELGM
AMRSLGYMPSEVELAIIMQRLDMDGDGQVDFDEFMTILGPKLLSSETREGFLGNKIDSIF
WQFDMQRITLEELKHILFHAFRDHLTMKDIENIIINEEESLNENSGNCQTEFEGVVQLEF
AECLNPYLICAFAMAFIISVMLIAANQMLRNGME
>L7I9W7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Magnaporthe oryzae (strain Y34)|TrEMBL
MSHPLGTTSSLGNLPSLILSVVAALILLRFYLEHTQGRDKSSVAFANKFGEENVKDGPSP
PPVETQKKSTSLEKTKPSGPRRIKGDVNKTGKNGGAQADITATGREILPLVFFSCVTGRT
DKVAREYAARLDESLRALPAVAGCSFRESRILDLSEIDYDEYFISVPKIEAQKEGSRVEL
LYLLLLPSFNIDTINDTFLEHLQETHHDFRIDTAPLAAILGYSVFGFGDREGWPTEEEGF
CFQAKEVDRWMAKLTARKRACPLGMGDSKTDAPERLSEWHDGVVDVLSLLARTGSLGEGV
PGSGDAVESEDEGGSNEDDDEVLIEENGWTEKKPKKSKSKALDDVEDIGRMLDTSRANGT
APPVAVDFTTYDKPKGGSRKQPAVQTVKQMVPKSSPTYTALTKQGYAIVGSHSGVKICRW
TKSALRGRGSCYKYSFYGINSHQCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVADPPD
MIFDGIRSGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLQLLHA
EHISSFLVCNAQHPDQLAALGHVTQLYVSIDASNKDSLRRIDRPLHRDFWERLQRCLDIL
REKRFRQRTVFRLTLVKGFNVEDEVEGYADMVEKAMPCFVEVKGVTYCGTSTSAGAGLSM
SNVPFYHEVTEFVTALEKSLRKRGLAYGLAAEHAHSCCVLLASERFLVDGKWHTRIDYEK
FFQLLEQKGPHGDFSPEDYMGPETPEWATWGNGGFDPRDQRVDRKGRPIEA
>A0A0C4DMQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Magnaporthiopsis poae (strain ATCC 64411 / 73-15)|TrEMBL
MYSTLEDGRLYFDRLSSYALELWHSHRTPICLYSFTCLILLRIYLHFAHGRPEEPVAFAR
ALGSAGAKSKPDPPPPTSKAIVTDEKLKPVDQPKVKASGPRRIRGEVNKEKTDKGPESGR
SREIQPVVFFSSVTGSTDKTAREYAARLEDSARAMPPAAGCQILAPMVLDLSEIDYDEYF
IAPPQLAPQQAQGRVELLYLLLLPSFNIDTINDTFLEHLQETHHDFRIDTAPLSPLLGYS
VFGFGDREGWPTEEEGFCFQAKEVDRWMAKLTGRKRACPLGIGDSKTDAAERLSEWHEGV
VDVLGLLAQTGSLGEGVPGSGDAVESEDEEASDVDDGEVLVEEDAPTPKKKTGRKTLSEA
LDDVEDIGRVLEASRTDGTAAAAAPVAVDFTTYGKDKTSAGRTRKPAAQTIKEMVPKNSP
TYAALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMEATPSLSCSNK
CVFCWRHGTNPVGTTWRWVADAPDLIFDGIRKNHYQKIKMMRGVPGVRAERFAEAMRIRH
CALSLVGEPIFYPHINEFLALLHGERISSFLVCNAQHPDQLAALGHVTQLYVSIDASNRE
SLRRVDRPLHRDFWERLQRCLDILRDRRFRQRTVFRLTLVKGFNVDDEVEGYADMVEKAL
PCFVEVKGVTYCGTSTSAGAGLSMANVPFYHEVCDFVTALEAALRRRGLEYGLAAEHAHS
CCVLLASERFRVDGRWHTRIDYDRFFELLDEKGPHGDFSPEDYMGPETPEWATWGNGGFD
PRDQRVDRKGRPIEA
>A0A101IIC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix harundinacea|TrEMBL
MVAHGAVKPCLWLRRSIRGGDQCYKNHFYGIASHRCVQMTPTLLCNHRCLHCWRPIDDMP
NSSGDWIEPAELLDGILEEQQRLISGYGGAPETTDLSRLEEAKHPAHVAVSLMGEPTLYP
MIKELVDEIKSRDMTAFLVTNGTMPDVIGEVRPTQLYLSLNAPDEETYLKVSNPQANLWS
RFLESLDRIRESPSRTVMRLTLARNLNMIDPQGYAKLIEIAEPDFVELKAYMHLGSSRNR
LERDSMPTHEEVMEFAGALSEILGYRLQNHVPLSRVALLSRGSAQERIEL
>A0A7C1M850|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MIPEKVKKVLKRQHYEIVGKHSAVQTCRWTKKSLIDEGICYKEKFYGIKSHLCCQMTPSV
MWCPNKCLHCWRAIELTLGDKLERDTDSPKEIIDGCIKAQRKLLQGFKVDKHSKKKQLSK
ANQDKYIEAQEPMQFAISLSGEPTIYRKIGELISELRKRGKTSFLVTNGLYPEKIKELVD
KNQLPTQLYVSINTPNKKLYQKFHRSSKKDAWERLNKTLEIMSKLKNKTRTVARINLVKN
LNMIEPENYAKLIKKAKPLFVEIKGFMSVGFARERLGYDKMPYHEDIVAFSKKIIKELKK
LKQDYKLLDEHYFSRVVVLGKSKKDLKIKKKEF
>A0A0P5EB92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daphnia magna|TrEMBL
MMKVVQPPLIGSFFLPSLGLAVLSLIVGYWVTRKKKDNIKSELDINESPSGLENELYSMP
ATENPKRKKKKHVCNCGSTQASNFEKHPSRIKIMYGTLMGKSKKFAEMLLGHVAEDGMEV
SAINLKECDSEDNFVGSDAKDTLFIFIVSTYAEGSPPDDAQWFYKWLEDSAFDFRVPKTL
LADVRFSVFGLGNSLYSENYNVIGRNIDNWLSQLGAERYAPLGLGDENVAESLHGNIEAD
FDHWSEGILNLLKQPQHTTVNKSGCSKGNDCCSKKGKKKITNKFQKKKNNILEEADVTYD
TDSDSDSNEPVLDLEDLGSFVRVENKAVEDSEEEEEINVENGETREMLTPQLRESLTKQG
YRLIGTHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHS
NPVGTEWRWKMDPAELILEGALEQHTKMINQFKGVPGVQPNRLVEGMSPVHCALSLVGEP
IMYPEINRFLRMLHEKKISSFLVTNAQFPEAIRQLEPCTQLYVSVDASTKDSLKRIDRPL
FKDFWERFLDSLRALSAKGQRTVYRLTLVKAWNVEELESYANLVKLGEPDFIEIKGVTFC
GTSKASTLTMENIPWHHEVVTFGEKICTYLEGYGLAAEHEHSNCILLAKRSKFFRDGRWN
TWIDYDKFHQLMLEYYLSGGKASFTSEDYMASTPDWAMFGSPEHGFDPLENRWHRKQPKK
DISGC
>A0A6I9L116|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Peromyscus maniculatus bairdii|TrEMBL
MGPLDVWDFSSPLLLLWVNRFYIYLGCALGVTLWICVQVVIKKQVTHSQEKSVPGAPGNS
LSLQKKESHVSGVKIFYGSQTGTAKGFAVTLAKAVTSLDLPVDVINLKEYDPDDSLIGEI
TSKNVCAFLLATYTDGRPTESAEWFCKWLQEAANDFRFGKTYLKGLRYAVFGLGDSAYRS
HFNKVSTNVDKWLWMLGAQRVLTRGEGDRNAVQSRHGSIEADFTAWKTKFVSRLQALQRG
EKRKTCSGDCKRGKCESTHPGAGEMRPHLQGELHPRDAEEEEPCESSSEEESGTQDYQSL
NSVVDVEDLGNIMNPMKKEKREKAPQEERGGVKRNPERSEDSEGRAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGLEVKHCALSLVGEP
IMYPEINRLLKLLHQRGISSFLVTNAQFPEEIRNLTPVTQLYVSVDASTKDSLKKIDRPL
FKDFWQRFLDSLKALAAKQQRTVYRLTLVKCWNVDELRAYAELVSLGNPDFIEVKGVTYC
GESAASSLTMANVPWHEEVVRFVQELVDLLPDYDIACEHEHSNCLLIGHKKFKVNGEWWT
WIDYGRFQELVLQYEQSGGSKAFSASDYMARTPPWALFGARERGFDPKDTRYQRKNKAKD
ISGC
>A0A5K1VGU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium knowlesi (strain H)|TrEMBL
MVQGDDEKKRRNLLQTIFEQHAVRKRKKAKINLRIVYGSEGSNSYRKARGFLKELIQFFK
DIENICNEVNRIVSEEGGSHPIFFNGRTNEVDHGENRLMRYFKEYSKLLQGKNEQTARTG
KKDKFHTEGVINSVHEVLEEFQEKEKKCSDKFVNYLDCCISNNVCTVNFDFVNGNEFNDY
SFFEHTTEYDLNVMVLFVSTASNGSFPRNCYKFEQLLEDLYNDFRVEKNFLKNIFYTCIG
FGNKQYGSTHFCTPVKKCDKYLTSLGAQKLFKTLKLCDEENNEEVFLVWKCTLFKTISLG
LLFYCFNFLHLGSFMPYADRKIYNSLQHYCFFFCGKAENRKGKKENIKMGTTHAASIQVP
QEHGNQIHETVQKGESSQAGDPLTGIVPKGDPSTKVLCSTCGEGTSDRCTSDRCTNDGYT
HLNGDEWEGMPTTEKSEDEMVEKSTHTYKKKEDLKISTSLCSSGEELEDLVPDKPKDMLT
WNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGCYKHTFYGINSYQCMEATPSLACA
NKCVFCWRHHKNPVGTHWKWNKDDAEMIVDEALKKHKGMIKELKGAHGVIKERFDEAVNV
RHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNAQFPNELQKLHKVTQLYLSIDAPN
EEALKNIDRPLFKDFWDRYIRCIKILKKRKERTVFRFTLVKEYNMMSEEILSYSKLIEYG
YPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAYSLIHSNGYLPDVYEIACEHRHSC
SILIAKKEFKINDKWHTWIDYEKFQFLVKQNKDFTALDYCAETPAWAVMGAEERGFNPCD
ERVYTKGKKKNKPPITENTSQS
>Q57XT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma brucei brucei (strain 927/4 GUTat10.1)|TrEMBL
MELLSVTPGDLLVGCWVLTFVGIIFFRWFMHRRRSVEDQPPEAAQTTAGAQIHNGKSIIP
NRRDAGEGSSCRCCSSNDDVITSENVETCGKQQKRKKILVAYATQSNTSYKLSNKLISML
NLALHENSSAYGTCGGSLVLDAASGVSCCCSRDPKAGVAPEIKLLQLKEEATECSTEHLL
ESGAYGLVVFFVSTYTGGTAPEPSHSFASMLKDAYLDFRVPRDVFAGVNFAIFGLGDIAY
GPEKFNRFAKDLYTWCKGLGGKFVIPPVYASESNTTTLFHVFSTALVKWIGRAAFTADGV
TVMKKKSMNGAQSLNRRLNNKNNEEEEQSVGGECVKDDEAVTSGSGNHNSQNGDPSEGCG
SDDGDSDSENSDNNDDKNDNNNNSDDGDAEDVEDIVGEGDDYFSSTTNGEPPELLYPRLR
ENLQRQGYHLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIASYQCMEMTPSLACANKCV
FCWRHHTNPVGRSFRWKVDPPRELIEGGLAGHRRMVKQMRGVPGVTPQRLEEALNVRHCA
LSLVGEPIMYPEINTFVDLLHEQNISSFMVTNAQFPEQLRDLKPVTQLYLSIDAPTPEEL
QRVDRPLFEDYWERCLACVRELRRKPQRTVFRLTLVNKYNTENVSAYADLVRLGWPDFIE
VKGVTYCGTSSTSTLTMKDNVPRHTEVVEFCEALCQQLATSNEPKEKRMWLGRDIVEEQQ
GAVAAAESGAETHVEGGMTTSSLCGPYRIACEHEHSCCVLISLRRFFIDGVWHTWIDYDK
FSELARSGRRDFTAAEYAAPTPPWAVFQSKERGFDPTQVRVMRKSGKSEVITSGC
>A0A7C3RAK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus fulgidus|TrEMBL
MKLLGELKGYQIVGKHSAVKTCLWLKKSLKDEGVCYKQKFYGISSHRCLQMTPALMCNQS
CIYCWRPLELLKGFRGWDDPEFIVEESIKAQHRLLSGFHGTAGVNRRKLEEAYRPNQVAI
SLIGEPTLYPMLPELIEEYRKRGFTTFLVTNGTNPEMLERVNPTQLYVSLTAFDEESHLA
LNRPPSSNWDKILKSLEIMRDKSRSVVRLTLIKGYNMDEKAIEGYSKLIELAEPDFIEAK
AYMYLGYSRLRLKWENMPEHSDIVEFSEKLAESISYEVKMESEPSRVVLLERVK
>A0A510E291|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfuracidifex tepidarius|TrEMBL
MILLEQGELKIDVMSKIFKELEKEKYHIIGGHSAYKKCHWTHEYLVTGRSCYKGKFYGIE
SHRCVQMTPVAAWCWFRCVHCWRLEPEDIGLDWDDTKMQGFDDPEFIAERSIEEHRRAVS
GYYGREGVRPERVKDASSPKHVAISLTGEPTLYEKLGDLIKEYHRRGMTTFLVTSGVRPD
VLASLEEEPTQLFVSLQAPNEMKHKIINRAVVPNSWNLVMRTLQMLPSFSSPTVLRLTLI
KGMNMSDKDIEQFSKLIDISRPTYIEAKAYMHVGPSTYRLSRDAMPRHQEIREFSKKLEK
ATGYHILSEHAPSRIVLLSQLDRPIQIGNAWNQKWDWSTKDTEDDINGEYKEAEKGCTEE
>A0A0R0GAG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glycine max|TrEMBL
MSISISLSSVPARLTLLAVFSATTFYCLYKYHRLRHLKLFLNPNPNPNPKIIFVSETGTS
KTLARRLHGLLASNDVAFDLVDAQHYEPEDLPKETLIILVASTWLDGAPSAASRFFATWL
ADAAADFRAGSLLLSRCRFAVFGVGSRAYGDSFNAVARGLAKHLRALGAAEVVPLFEGDV
DGGDVDAVFDRWCEKVVAVLKSGSVVESCDNDGAEESGVVSSSEDESDVDSSEIVDLEDI
AGKAPSWRKAVANGEESNEKLNGRREMVTPVIRANLEKQGYKIIGSHSGVKLCRWTKAQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIEIVNS
AIDLHTNMIKQMKGVPGVTLERLSEGLSPRHCALSLVGEPIMYPGINALVDELHKRRIST
FLVTNAQFPEKIKSLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKEKHQ
RTVYRLTLVKGWNTADIDAYSKLFSLGEPDFVEIKGVTYCGSSTTSKLTMDNVPWHADVK
AFSEALALKSQGEYEVACEHAHSCCVLLAKTNKFKIDGQWYTWIDYEKFHDLVASGRSFD
SRDYMAATPSWSVYGSEEGGFDPGQLRYRKERHHKSTRNQAG
>A0A090I6Y3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium formicicum|TrEMBL
MPLSDQNIKTLEKKGYRFVGSHNHSAAKVCHWTKKSIMDDGVCYKEKFYGIKSHRCLQMS
PSIPFCHHKCLFCWRDVDVTSTSWTEDYDDPGQIIDECIEAQRKLLVGFFGNPNANQEKV
LEAQDPTNAAISLAGEPLLYPSINQLLEEYARRNFTTFLVSNGLSPEKLGNLDPEPTQLY
LSLDAPNREVYQKICDPQIPDGWERLNHSLELLSSFNCRTVIRMTCVAGHNMTHPEEYAR
IIESTNPDFVEIKAYMYVGSSRERLKFENMPRSRDILSFAQNIASLCGREIVDQSLESRV
VLLA
>E0VTT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pediculus humanus subsp. corporis|TrEMBL
MVYLLSGFTFVGPFFFPLCIFLLIFFLAWNVKNGYVRNKIFKSNFNENLTDVSHNIIESS
NKSAAKSKPLLKSECCKEDDEKNLFNNESVFKNVKIYYGSAGGKAKLFSEKLANCAKDYN
IISEVINLSHYEAEDKLPNEKYCVNVFILSTYEGGKPPPNAEWFCKWLEEVSSDFRVHKS
LLKNVKFAVFGLGNSFYSDNFNKVAINVDKCLHKLQGERIKKISLGDENVTNSKNGSIEK
DFDVWVWELLDLLKNPEKVKLGCKCNGKKQNGNCKTIESDGYNDSSDENEGTSYSSGIID
VEDLGQKILSSKSADNGIRDMVTDQLSATLTKQGYKIIGSHSGVKLCRWTKAMLRGRGGC
YKHTFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGTEWKWNMDDPEFIINGALENHY
KMIKQFKGVPGVSLDRLQEGMTARHCALSLVGEPIMYPEINKFITLLHEKQISTFLVTNA
QFPDAIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWERFIQSLKALSDKGQRTVYRL
TLVKSWNVEEIQNYADLVNLGKPDFIEIKGVTYCGTSKASNLTMENVPWHSEVVSFGTKL
CSYLDNYKLACEHEHSNCILLAKTKFLINGKWHTWIDYDKFHSLVKNYQSSNGEKTFSSD
DYIQETPSWAIYGSYEKGFDPTETRWKRKKEN
>A0A817GT34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood2|TrEMBL
MAVDLYIFAAGTALTGLKSSSKSQSLTKIISQEKNGITIVFGSVKGNSQTFAQLTYDKLS
NELNRQVILQDLNDITDPEEFLQIQTKNQRILLIFISTYEDGTPPPSAKWFVLHLQEAAT
DFRVSKNELEKLTYAIFGCGNSLYNDNFNKVAQELDQCLLELAANQLIPTELADENTAKS
LEGHYSKWSSQLISAFQSPKTEKCDCSNENSINCCQSSKNNEHSIEKKDNGEQLRIESDD
DDEDGGCKNGNDDVMDLEDMGDYMETHSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGTH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSW
QWKTDDAQTVCQGAIENHYKMINTFKGVPGVLPSRLAEGMKIRHCALSLVGEPIMYPHIN
ELIDLLHSKQISSFLVTNAQFPHEIRSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWER
FLDSLRALKDKGQRTVYRLTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASH
LTMANVPWHEEVVTFVQLLCDRLPQYDLACEHEHSNCILLAHNKFRVDGKWHTWIDYERF
HELVTRHKATSGVETFTSLDYMAVTPDWAVLGSNERGFDPSDTRWYRKATAKKNLSGC
>A0A8D5ACN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter arboriphilus|TrEMBL
MSNSLNNQEKNVSLSLEDQKKLEYSGYRFLGSKGHSAVKICHWTKKSILNEGFCYKEKFY
GIESHKCLQMSPAVPFCHQKCSFCWRDLSLTKTEWVGDYDDPKTIIQDAINAQNKLLCGF
FGNDKADRKKLEESKKPNNAAISLAGEPMFYPDINELIAEFKKQDFTTFLVSNGVMYEKL
ANLQNEPTQLYLSLDAPDKKTYVDLCNPQINDAWLNINKSLETLNSFDSRTCIRTTCVKH
KNMFDHENYAKLIDLANPDYIEIKAYMCVGYSRDRLTLDNMPTFNEVIDFAQKIADLTGR
EITNDSEISRVVLLE
>A0A843ALS3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter arboriphilus|TrEMBL
MSNSLNNQEKNVSLSLEDQKKLEYSGYRFLGSKGHSAVKICHWTKKSILNEGFCYKEKFY
GIESHKCLQMSPAVPFCHQKCSFCWRDLSLTKTEWVGDYDDPKTIIQDAINAQNKLLCGF
FGNDKADRKKLEESKKPNNAAISLAGEPMFYPDINELIAEFKKQDFTTFLVSNGVMYEKL
ANLQNEPTQLYLSLDAPDKKTYVDLCTPQINDAWLNINKSLETLNSFDSRTCIRTTCVKH
KNMFDHENYAKLIDLANPDYIEIKAYMCVGYSRDRLTLDNMPTFNEVIDFAQKIADLTGR
EITNDSEISRVVLLE
>A0A370PME3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus phoenicis ATCC 13157|TrEMBL
MEDLPIGGYKSSPFELKRPVVSEIVWDFFSIGQASHIWDTMKEKYSSTMTPLYIGSLSTR
TSSAASAPPPPPSPATSSTSKSPNHSPPPPPPPPPSTRRRHTPSHYKQRGHHLTCRFRLL
RLPEMPSPFGQFSAGTNQRPRRWSQKIPRKSRGTESVRTSTDPRTSIDSTLTRRVWAAFV
SLCLVLATCIRPSTDSVGYCDVSSSPSAPRPLYLARLFESFRGHKGSQIPPLSHGSRLFF
SIYLRWRDLETKVIMLSLCDRASTNGSFCLGLLAFWHSYRLPVLLALATLLVLVRAYRKL
QPKSKIATASSIPSSPRSHSPEKLEKTISNSTEKDVGTDSKPSVVEKDASQKQAGPKRVT
GKKPLKVAGRRRGSDQEPAVSFIQPIIFFASLTANTERYAQVLLEELRAAARDRADPDNR
ERGLLPPQIHDLSYVDFDDYFISAPKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDE
THHDFRIDTAPLSGLAGYSVFGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLG
FGDVKSDAESALKEWSRGLQDILGEIVENGGLGEGVPGSGDPLESDEEDLDDEGSESDKA
NGRKRNKNQSVVDLEDIKFSSDAASGSPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWR
HGTNPVGTTWRWKVDDPELIFNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLV
GEPIFYPHINRFLDMLHSEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKID
RPLHRDFWERFQRCLDILREKRHYQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEI
KGVTYCGTSTSAGAGLTMQNVPFYEEVQQFVTSLNAELERRGLNCCALIASERFHVNGKW
HSRIDYDRFFQLLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQ
AAAATEAQG
>A0A8D4VKB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus chikugoensis|TrEMBL
MGLSGSMRSEACKALRKQGYQFITPNSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRC
VQMTPTLKCNQHCLFCWRSFEHEVVEEEECPPDVIVANLRRVQKKALSGYKVSPYVEPGQ
FAEALDPTMVAISLSGEPTCYSRLPELVDALSADGYTTFLVSNGTRPDVLARCRPYQTYV
SLDAPDRETYLSLCRPMEDYWDCIQESLAGLRGRRSAVRTTVVRGYNDFSPERYAALYQD
SGARFIEVKGYMHLGYSRNRLQRDRMPEHHEIRAFAEKITEHCDYAIKDESPVSRVVCLE
QKI
>A0A8H4XQD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium zealandicum|TrEMBL
MDWANYSSPSRLDSFVDGESLLYILGTYLEALTKPTELVDVWHIHRTPIILTVLVILGAA
RAYLHINSQKPELVTFKKVYDEPIKPTIVTEAKTKVAEPIEEKKDAKPQGPRRIKGGLAR
KPSKNKEEEKDLTRPILILAFFSSITTKTDKIAQAYLKELEGRLDQLSKQSGRQFLKPEL
RDLTDIDFDDYFITPSSTHPDTDIFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPL
SSLLGYSVFGFGDKENWPTEPEGFCFQANQIDKWMSKLTARKRAYPVGMGDMKTDHEARL
QEWSKGVEEIIELVARTGNLGEGLPGSGAADESDVEDIAEDEDDGEVLFEDGSNDTKQKK
SNGGSKLDDVEDLGRMIRKDDGTATAQKGPLAVDFTTYGSSTKKTVPIGPKEMVAKNSPT
YAALTKQGYAIVGSHSGVKTCRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKC
VFCWRHGTNPVGTTWRWVVDPPDLIFEGVKVNHYKKIKMLRGMPGVRAERFAEAMQIRHC
ALSLVGEPIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALRAVTQLYVSIDAADKES
LRKIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLP
CFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSC
CILLASERFYVDGKWHTLIDYKKFFDLLEERGPDGDWTPEDYMGEATPEWATWGKGGFDP
RDDRVDRKGRKIEAS
>U4KXY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyronema omphalodes (strain CBS 100304)|TrEMBL
MSSLADEPGALHEILGLWHEYRTLVFTAIAVAAVLYKCLGSLRTLLHQETQSIGATTAAQ
KLNGIVVDGQPALKIAEKVSDYTEIVEPKLDAPRVKAKVEPKRVSGKKRGSPIRRITKPQ
NEKDLESDIQICIFYASLTGSTSSYVEKFKNDLFSDKEGIYPKLSIPTPSNSLPGIAPSR
NILPPQLFNLEEIELDDYFVALPTPPEGKSVKYIYIVVVPSYETDSPVAAFLDHLQETHH
DFRIDSAPLSPLAGFSVFGFGDSSEWPESEGKFCQDAVQVDKWLGKLSGGRAGSRRLFPL
GMGDMNPASSADGQGTATANFREWRIHLEDSMQEYFETGEMSAGADLRGAVESGDEDSDV
DIAEDETEKDMMDLEDLGTMINRNPTIKKSSTPAKVYLPVDFTTTAGKLALEAGEGQSPL
RKDMVPKDSVTYKALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIRSHLCME
TTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEEIFKGVVEGHYRKIKMMKGVPGVRAD
RFSEAFRIRHCALSLVGEPIFYPYINEFLALLHGSQISSFLVCNAQHPAQLRALGPVTQL
YVSIDASNKESLKKIDKPLHRDFWERFQECLDILREKRNKQRTVFRLTLVKGFNLEDEVK
GYADLVERALPGFVEIKGVTYCGTSSAGEAGLTMGNVPFWEEVQTFVEALNTELNARGLD
YGMAAEHQHSCCALLASKRFHVNGKWHTLINYERFFELLKEGREFSPEEYVGEPTPEWAN
WGNGGFNPEDERVYRKGKGPKKETETDSGGCG
>A0A7L4E606|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hirundo rustica|TrEMBL
MDTWSYFHTCLVSIWLHRFYIYSAVAVGISLWIVIQFTTTGTKRKVTEPGTADKLGNGCA
PAQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYDPEDGLAEETS
SRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSAYVDH
YNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTRLQVLCKGE
KKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTETEELFETSSEEEAEGTDSVIDVE
DLGNIMGHMKKAKVLLLQRVWNVHAVSHCGYPSVYSVCQFLQAKLYCVMTCALFSGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYP
HINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKENLRRIDRPLFKDF
WQRFLDSLKALAEK
>A0A2K5QP80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cebus imitator|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGFVSLHNKDIFVSGVKIFYGSQTGTAKGFATVLAETVVSLDLPVAIINLKEYDPDD
CLIEEVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSVYASHFNKVGKNVDKWLWMLGARRVVSRGEGDCDVVKSKHGSIEADFRAWKTMFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSEEQDELHHRDIEEEEPCEGSSEEEF
GGEDQQSINSIVDVEDLGKIMDYMKKEKREKEQQEEKTSLFGNTGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVKHC
ALSLVGEPIMYPEINSFLKLLHQRQISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKS
RMCLYQRHENGLILERGTPGQLQADHSGWS
>A0A8H7ZJB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida metapsilosis|TrEMBL
MSSGSFILAVCAAFYLYDGGRWTIVVSAFVLTYLYKLERRSASGKAPQQTVSKVSQSNSE
SPIYAVDFTSTTFTPSATTSLPKTVRSRAKRSPKIIKASKPASSQQLEPVLTKSQVDLKK
SQIYIFYTTLTGSSLRLAKALHEKLHLMELTHEPKLLSLDDDVDDLEKFFLKTPKDDENT
KNIYVLVLPSYETDSPIDYFLEHLIDTYQDFRVDKYPLRSILGFAVLGLGDSESWSGDKF
CYQAKLADKWLGKLGGRRLYPLGEVCMKYEGEPKAKEWIQNFAELLVDEEPFYIDENNDD
EFDDSDKEEENSDDANTLVDVEDMGDIIRKTGQRSTQQMEVKQMVAKDSPTFKTLTKQGY
TIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTN
PVAKSNWRWELDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFQEAFKVKHCALSLVGEP
IFYPHINEFVGMLHEQHISSFLVCNAQHPDNLAKLSKVTQLYVSIDAPTKTDLKKVDRPL
NSDFWERLMSCLDILRTTQSHQRTVFRLTLVKGFNMTDIKSYADMVERALPSQIEIKGAT
FCGSSNGNGNPLTMQNIPFYEECKEFVRALNDELRTRNLGYDIAAEHAHSCCILIAHEKF
KIDGVWHTHIDYPKFFELLESGQDFVDIDYIKPTPEWAVWGSKEAGFNPVDTRWDRKAEK
LKNKIAREEEDAKRKEQIEVI
>G0WCH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639)|TrEMBL
MPLNIITTITVISAVAVYYFLLGGRFSVSLMILTTYAIYYTENNKTNNEPVSDNKNTAVT
STTSAVEEDIELIKTEKKGGSCCSGGNGKNGGSGCCSSKNKNSATKKSGKSCCCSGKKKK
LTKENEQESDTSSNDDSDSMTIDFTGSFVTKKKKMKSARTPKVFTNSKNDSSIQSSITED
VPIDETKITDKNILKSNDAELIKSALTISNDTLLNSQIYVFYSSLQGAAERSAIKVHKIL
SNMEELKNEPKLMNLDELNDIDEYFVDVPCENALYILVLPSYDVDCPLDYFLQTLEENYN
DFRVEGFPLRKLVGYTVLGLGDLETWVDKFCYQARNADHWIAKLGGRRIFPVGEICMKTG
GDPKIEEWATLLAETLKDDEPIIYEYDETCDIEEDAGEMYADDAGSDDEGLADVEDLAGK
ESKNKNSMEIKQMVTKESPTYRNLTKQGYKVVGSHSGVKICRWTKNELRGKGSCYKKSLF
NIASSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWETDDPEYILENALAAHYSMIKQM
RGVPGIIAERFTKAFKVGHCALSLVGEPIMYPHINRFVELLHEKEITSFLVCNAQHPEAL
ESVGKVTQLYVSIDAPTKDELKKVDRPLYKDFWERMLQCLDIIRTKQSHQRTVFRLTLVK
GFNMGDISSYADLVQRGQPCFIEVKGATFSGSSNGNGNPLTMQNIPYYEECKKFVKNFSE
ELQRRGLGYEVAAEHAHSNCILIANTNFKVNGKWHTHIDFDKFFELLNSGKDFTYLDYIS
KTPEWALFGNGGFAPGNVREFRKEKKIQAKKIRLEEEIKSQDLTEVIDEVEKPMPEIPTA
VKA
>A0A7C7XWX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDLALKAKLQKQRYHIIGEHGGVKTCHWTKESLLRDRQCYKGKFYGVASHSCLQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLEMLYESVRAQRRLLSGFKGNDKVPREKWQDAQNP
KHVAISLNGEPTLYTRLSEYMELCHEHGMTTMLVTNGTLPKVIENLDVLPTQLYVSVDAP
NKEIFDAVCKPKWNTNAWDKFEETIDLLPSLDTRIVCRHTLMKGINMSDKNIEEFAKLDL
RADPDFIENKGYVFVGHSRENLAAENMPSHEDIMDFSNKIAPLTARKVLSDSRPSRVALV
GTEISPMPIPVATKFFPEDLGIAPSVKHLTMAN
>A0A5N6ZII4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus caelatus|TrEMBL
MAELSLTEGLVTIWHSYRIPILIAIASVAIILQAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQTRTGESEKPAVTEKSVTKPASGNDPVPKVVSGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTATTERYAQILLEDLRTAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
NILVDILDNGGLGEGVPGSGDPLESDEEDLDDEENDGNRSKRRNDQDVVDLEDIKMGSDE
QSGSGPVPVDFTTAGKSAAPSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHNEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A6P7DG09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ovis aries|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNLQEKTTPKASQD
LMTNGYVFRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLDLPVAVINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGERKRCRGNCKKGKCESNQRSSEAMEPGSRAQEELHHGDAEEEEPFGSTSEEESD
TEDHQSQNSVIDVEDLGKMMDHVKKEKREKELQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKGERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKVN
YSFPSLLWKEAYIQPVSKE
>A0A2N0PZU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis|TrEMBL
MLLRYFESLYLSYQALFWSCLAVGGIVVFYVTLLNSKKKKKQIIEDNKKIRELSAVNKEK
TTGKGLRKRFTRSTKKTSNQTCTNDSGEKSACCGNGGVSDCCKNQLSEETYHIITANKST
KISVKIFYATQTRTAKYFAQQLYQSFTKHSNCECSIMDIVEYETEDFLSESAICIFLIST
YNVEGPLDWFYKWLEDTRYDFRVDKQALSKMKFAIFGLGDSAYGDQFCIQPRNIDKWLGQ
LGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDPSYALNNVSSNLNYDSYSESDSDSD
NNNNSDTEMVDVEDIGALAPKLQAARKSKEEEEFVYKNSNGRPKRTLSEQEVPINEPKEM
VTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSHRCLETTPSLA
CSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLSNHYKMINEMKGIPGIRADRFQEAF
NVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMVCNAQHPSRLRALDKVTQLYVSVDA
STKESLKKIDRPLFKVFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEIANYVELVRRG
KPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFVKHLNENLGDTYEIATEHSHSCSIL
IANTKFKINNKWYTWIDYDKFFELLEKGEHFTSLDYIAPTPSWALFGSPEAGFNPEDQRF
YRKSKKNNNSVKNGGC
>A0A8H5TDF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium heterosporum|TrEMBL
MDWANYSSPQRLDAFVDELVDVWHIHRTSILFTTFFVLIAVRLYFQFNGQKTELVALKKI
YEEPVEPAKPKVVVEEKTPTIEPIEEKKNAKSQGPRRIKGGIARKPSKNKEEAVDTIRSV
LPVVFFSSITTKTAKIAQAYVEELGGKIDGLAKQSGRKFLKPELRDLTEIDFDDYFLTPY
KAQGDADVFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPISGILGYSVFGFGDTEN
WPTEADGFCFQAKEIDKWMAKLTARKRGYPVGMGDMKGDHEERLREWTKGVEEVIEHVAR
TGNLGEGLPGSGAAEESDIEEIDEDEDDGEVVFDDEEPKKKTKSGSLDDVEDLGRMIRKD
DGSTTQKAPLAVDFTNYGSSAKKMVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTC
RWTKSALRGRGSCYKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDP
PEMIFEGVKKNHYQKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPYINEFLGML
HAERISSFLVCNAQHPEQLAALKAVTQLYVSIDAADKESLRRIDRPLHRDFWERFNRCLD
ILREKRFRHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGL
SMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDY
KRYFELLEEHPDGDFTPESYMGEATPEWALWGNGGFNPEDERVDRKGRKIEAS
>I1PFZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza glaberrima|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAVVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A5P8LWW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicrobium sp. ZPS1|TrEMBL
MSESDGPKQVDDPDYHSENHTAAQTCGWTANALRGEGKCYKYIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVQWDDPSAVADASLELQKRLLSGFGGNEKVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFHDRDITTFLVSNGTNPDVLDRCDPTQLYVSVDAP
DRKTFDDTVKAVEDSAWDSLIDTLDVLADKDDTRTVIRTTLVKGHNMHHPAWYAAMCQRA
DADYVEMKAYMHVGHSRGRLDRESMPSHDEVRAFTEEVGGFLPEHDTMKEVEESHVTLLA
REDETWVPKLEKSSEFWERDPVVSY
>A0A497SCE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MFMVSEALRKELEGQQYRIIGNHSACKICHWTRQSLENKGVCYKEMWYGVKSHRCLQMTP
NITCDQRCMFCWRIIERTALHSKLKHDEPSDIIDGCIEQQKHLLNGFPGFEGTNMRKWKE
AQNPTNAAISLLGEPTLYPKLSGLIEEFRKRGITTFLVTNGMHPEVLADIKEPTQLYISL
DAPDKVTWKALDRPAYPDFWERLNGSLETMNSMKCRKVLRLTLVRGHNMKDAGGYARLIE
KANPDFIEAKAYMHVGESQKRLPRSAMPSHDEVKTFAEQLSAETGYCIGGEQRPSRVVML
KPS
>A0A7L2G6W8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nyctibius grandis|TrEMBL
LDVSVDMWNHFYTCLVSLWLHRFYVYSVVAFGISTWIVVQFFTTKTKTKVSEVLLHELGE
DKLVNGYATLQAKEVCVAGVKIFYGSQTGTAKRFAKDLAEAVISLNLPVEVISMGDYDPD
DCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVNDFRFGKTYLKGLRYAVFGL
GNSAYVDHYNTVGRNIDRWLWLLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSR
LQVLCRGEKKPCSGKCKKGKCKSLGKQSKESSDHEHGASEYENTEAEELFESSSEEEAGA
EEAGGTNSVIDVEDLGNIMSNMKKAKVLLWTRENAGRKEEGEKREMITPALREALTKQGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPI
MYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLF
KDFWRRFLDSLKALSEKQQRTVYRLTLVKAWNVDDLKAYADLISLGKPDFIEVKGVTYCG
ESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKIDGEWCTW
IDYDHFQELVREHERSGGSKTFTAADYVARTPRWALFGSRERGFDPLDVRYQRKNKARDI
SGC
>A0A1V4US46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaB.Bin018|TrEMBL
MDSPDNIDGIEAKKTLAKQGYHLVGSGAVKPCLWLNRSMRGGDQCYKHHFYGISSHRCVQ
MTPTLRCNHLCLYCWRPIDSVLPEEEPMEPAALLDGILHEQQRILSGYGGAKTTDRSRLK
EALEPKHVAISLMGEPTIYPYLQELIDLISRRKMTSFLVSNGTNPEVLESIRPTQLYISL
NAPDEGMYRRISQPNGPFWPKIQESLSILKNHNCRSVVRMTVARGLNMERPVDFARLLES
AEPDFVEVKAYMHLGRSRTRLDRQAMPDHAEVLSFARALGNEMGYELSMDVPLSRVALLS
SGRICRSLDS
>A0A5N6DTN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus parasiticus|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILVRAYGKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKAVVVEKSVPKPATANDPAPKVVSGPKRVSGRKPLKVAGRRQEDQGPPL
SFIQPIIFYASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
DILIDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAALSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKGLQAATE
>A0A835X287|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGETVEEENQIIQIKPGIAQQLKKAKYGVSDHSTVELCHYTKKSFKNGGDCYKKKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEKVAEPEEIINKLLPERRKLIV
GHYGDPKSDKKKIDESLLPQHYAISLSGEPTMYPKLPDLIKYLNSLPNTKSTFLVTNGQE
PEMIQKLQDEDALPTQLYLSTNAADVDTFMRINRPRYKDSWERWNTSLEMLAKLKTRTVL
RITLIRNYNDQDEIIPAFASLLQRSNAHFIEVKSYMHIGRSTNRLEHEDMLDMEEVQHFA
YELAKQSGFSVMDESFISRIVVLQNQKRFIDRWIPTYLKTN
>A0A8E2EHD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lepidopterella palustris CBS 459.81|TrEMBL
MTLQTSVWGLPSELLAIWHAHRIPILLSTASLLGLVRLTIYLRSRREKVAQSPAPGSPAA
KNNDLDLAWIAPETGPEKNILQIDNHAEDIAIAVAPTAKARQGPKTVRGNKLARQTTKQA
TSFDSTADRVQPLIFFSSLSGTTEIYASQLMQDLSTWIGQAQTSQSIEKPQLHDLSYLEY
DDYFISPPKSDPNTKYFYLVLLPTYNIDTVLSTFLENLQETHNDFRIGTAPLSGILGYSV
FGFGDKEGWPTEEEGFCSQAKEVDKWLAKLTGRRRAFPLGMGDVKGQTQERLHEWRLGVQ
EALIEVASGRGLGEGVPGSGDPAESGEEDVDEMEDSDGEGVIPTKQAKRTKLAKLDDLED
LGRMITTSSSGPLAVDFTTYKSPKSGATVPAAPKEMVPASSPTHAALTKQGYTIIGSHSG
VKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRW
ITDPPQVIFDGITTAHYKKIRMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEL
INIMHSRRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFC
ACLDILHQRRFEQRTVFRLTLVKGFNMADEVRGYADLVERALPGFVEVKGVTFCGTSAAG
NAGLTMQNVPFYAEVQEFVTALVEELNKRGLGYGIGAEHAHSCCVLLADERRFKRNGRWA
TRIDFERFFDLYEGKVKGTAEDGDGWRPEDYVGDDTPEWALWGKGGFDPRDTRVFRKGKA
RRDAALEEALEEAGLGSLGVSVTGGDETAER
>A0A7C8NNG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MAEMYKSRSPDLIELWHTIRIPLIIAIGVLYITIRLRSILRARAPVLTTPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPVKPNPGAPPAVEGG
EEITQRNGKSIQVFIFYSSLTGSTAKYADKLSNDLFSEPLHIPKPTPPSVDNAEPEPVVE
KATFLPPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGFFCGQAKEADRWMSKLTGGKRVFP
IGMGDVKGDALASMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPSKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYANLVEKGLPAFVEIKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNGALQKRGLGYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTA
EEVAAELAAEAAEAESGCG
>A0A6G3ZNA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorussus sp. MSC15.2|TrEMBL
MSESDTVEETSTSNRDSQSSDDGPKQVDSPDYHSENHTAAQTCGWTANALRGEGKCYKNI
FYGIESHRCIQMTPVVKCNERCVFCWRDHAGHAYELGDVEWDDPEAVVDASIDLQKKLLS
GFGGNDEVPRERFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPE
VIRECDPTQLYVSVDAPERHTFDEVVKAMEDDAWEKLVETMDVLAEKDETRTVLRTTLVG
GENVRHPDWYAGFYRRADPDFVELKSYMHVGESRDRVARESMLDHEDVMAFAEQIQEHMP
DHEYLKEVPVSRVALLSKTDDTWVPKLKKDSDFWARDAVSGD
>A0A151E4B1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon SG8-52-2|TrEMBL
MNNDFKKILEKQHYGIVGNHSAVKLCHWMRQSLLFNRECYKQSFYGIKSHRCLQMTPSIS
QCNHLCLFCWRHQGFNEKEFKKIDDPEYILDKSIEAQKKLITGFKGDDRCDNKKWEEANK
PNMLACSLSGEPTLYTKLGEFFEICHKRKITTFLVSNGTNPKALENLDPLPKQLYISIVA
PNKDVYKKLCSPLTKKSWEKINDTLELLPSLDTRTVIRHTLVNGWNMNKEYINQYVKLDR
KASPLFIEPKGYVFVGYSRKRMNISNMPTHKDIKEFGKTLAINLSYELTMERSDSRVVLL
SKKSKTERFDK
>E4XVS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oikopleura dioica|TrEMBL
MGKGVERAILNLGIGVAFGAAVYFITVYLRERKNRLESSALFSGNDIGCCQNEEPLSCSD
NTGACCGEEAPGAKQSADASGGGCGTAGSCCGGSSVPKTIKKGKARQAPREKLVQKVVFL
YASRNGAAEKLTDDVKQYLSAFNKGLEMVKVDAQNMTIQQVEEAFCDKGRNSLFVFICSS
YPDDEFVDNLKSFFSESASDWRFSKSELKKCAGMIPIILGDSTFGDDVYCEPARTIARQF
SLLGGLRTNHFEIDNLKEKPETYFKEICQLIDETIGNGCVEEPVDEGADTGSSDEEAVDS
ADDELELPGNSCKSGNVPDLEDIANVVRPTSSQVRPNRTRVAKEMLSDKLRGALSKQGYH
LVGSHSGVKICRWTKAQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTSWRWVTDEPKMLVDGMIAGHRGMVKQLRGVPGVTSEKMVEAMNPVHCALSLVGEPIM
YPRIAEFLDYLHSHGLSSYLVTNAQFPDEIKGLPPVTQFYTSIDASTQAELKAIDRPLHK
DFWERFQQSLNNMKDICGRTVYRLTLVGGFNFFDAENYADLVKLGEPDFIEVKGVTYCGT
SNNAELTMKNVPWHEEVVDFCEQMCSHLPEYSISCEHEHSNCVLISNHKYKTETGWNTWI
DYHRFQQLYDEWKENGTKFTGVDYSRETPAWAVYGSEERGFDPSMKRHYRNC
>A0A8H6R1M9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus felis|TrEMBL
MSDRFPNIMLTDSSFIDLLAFWHSYRLLFLVALSTAFVGQRFYRKLQSRTKTTASSSVPP
SPRSQSPEQTEKGASLESSNQATTEKAEQQLPLAKGPPKGTSGPKRVTGKKPSKVAGRRG
QTEDAEPLSFIQPIIFFASLTGNTERYVKILLEELRAAAQKRADLQDRERGLLPPLIHDL
SYIELDDYFTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGAL
SSLAGYSVFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGFGDVKTDAESSL
KEWSQGLQDILFDILENGGLGEGVPGSGDPVESDEELDDEDVDKSNAQNVMDLEDIKFGG
DKNAAGSPIPVDFTTAGKPSSGQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWT
KSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPEL
IFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGE
HISSFLVCNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILR
EKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGTTTSAGAGLTMQ
NVPFYEEVAQFVTALDAELQRRGLKYGIAAEHAHSCCVLIASERFNVNGKWHTRIDYDRF
FELLEKEKADGTSFGPEDYTRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEH
>R7YG91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coniosporium apollinis (strain CBS 100218)|TrEMBL
MLSTSLCSLPSELLSLWHNYRLPILLSTVALLTILRIVVHLRQNRERLSQSPVPGSPAQL
PESKDPLLLAPGAVEKVAINDGHLEDIAIAEPPLLRSKPGPKRVIGSRVPRQASRRTIEF
DSEEDRIQPVIFFSSLSGTTEEAAKTLVKDLDAWRGASTPRVLQPQLHDLSYVDYDDFFV
SPPTSAPSTKHFYIVLLPTYNIDTSLDPFLEHLKETHHDFRIDTAPLSGLLGYSVFGFGD
KEGWPTEEEGFCSQAKEVDKWLARLTGRKRAFPLGMGDVKSDARQRLLEWRLGVQEVLRD
IASGKGLGEGIPGSGAAVESDEEDVKDAEDDGAEESEAPRKARKPKKSARVDDLEDLGRM
VKSSTSGDPSGPLAIDFTTYKSTSTAAPAPLKEMVPASSPTYAALTKQGYTIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEAIFAGVKEGHYRKIKMMRGVPGVRAERFQEAMTIRHCALSLVGEPIFYPHINEFTA
MLHAERISTFLVCNAQHPDQLAALQPVTQLYVSIDASNKDALRKIDRPLHRDFWERFLRC
MDILREKRKEMRTVFRLTLVRGFNIDEEVTGYADLVERALPCFVEVKGVTFCGTSTSAAA
GLTMQNVPWWHEVRTFVLALNDELNRRGLRYGLAAEHEHSCCALIGSEAFRDAEGRWCTR
IDYEGFFRCLESGKPFGPEDYRGPPTPEWALWGKGGFDPRDVRVDRKGRVKEVN
>A0A7C1QZJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp|TrEMBL
MALTFKSNPNMPEEVAELFKKQHYALVGRHSGVKLCHWLKESIKRDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLIVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQLYVSLTAPDLETYNRVNVPMIPDGWDRIKETLRLMKDAQTRTVIRLTLVKDE
NMHNPKGYAELIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A8B6XQG4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hydra vulgaris|TrEMBL
MKALGIFNLSMMFLFAWCSLSEDEYKSDTWQYDFVLWWSYAKFPLATFVLASTLTTWLFI
FFNRDRFQLKGKRVEVENTPFKVYYGTQTGNAKYFSEIFKEYAESNGIKTSVINMKNCEP
EEVLLEETDSNSLCVFIISTYMGGSPPESATWFCTYLKEASDDFRVQKNLLKGLKYTVFG
LGNSLYEDHYNTVAISLDKWLHKLYANKVFPLGLGDENVSRKEKGTISDDFTTWMKTLVL
EYQKSQCFTVENKTIGEKKVEEEKKYESESEDESTAGSGGGGCKSTSGTSGIIDVEDIGK
VINNQNQDEYDESFVGEKTAPVNREMVTPLLKKSLEKQGYKIIGSHSGVKICRWTKSMMR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWAMDDPNIIVEKA
MENHYKMIKQFKGVPGVKLDRFQEAMDIQHCALSLVGEPIMYPEINKLINLLHGKKISTF
LVTNAQFPDAIKQLKPVTQLYVSVDAATKESLKRIDRPLFRDYWQRFLDSLSALSEKGQR
TVYRLTLVKAFNTEEIESYAKLVSLGQPGFIEVKGVTYCGESKASSLTMENIPWHEEVVS
FVKTLAESLPDYELASEHEHSNCVLLCHKRFKINNKWHTWIDYAKYHELIKAYEDSNGKK
TFSDMDYLAPTPEWAVFGDDRKGFDPNESRWHRKKKKDISGC
>A0A101XBH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldivirga sp. CIS_19|TrEMBL
MGESRVKVTLRYHEFADGRIVISRDALATLKKAHYGVYGHATVELCHWTKSALTGGPSCY
KVKFYGAPVGGSHRCVEMGPVGMMCSNKCIYCWRPSESFDPYEPGYGEVMSPEEIINGVL
KERRRLLSGYFGHSRSSRGKVLEALQPTHWAISLSGEPTMYPRLPELIKAIKALPNTKSV
FLVTNGLYPEMIERLWREDALPTQLYLSLNAPNRELFYKIANPVIHRDDAWERVLRSLEL
LSKIPTRTVVRITLIRGWNTMEDLIPQFAEVLGIGNPHFIEPKSYMNLGHSVYKLTKDNM
LRHSEVREWSMMLLKALRDKGMDYVFMDEDPNSRITVLQNMKRYVDRWIEKPTNP
>A0A7J3JRU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MNSTSFNGYKDYISHAFNILRRQKYHIIGSHSAVKKCYWVHKALIERMFCYKAKFYGIES
HRCMQFSPAILWCWNYCLHCWRYRTEDQNSRIWMKLPEDIDDPRTIVDIAIKEHRRTISG
YRRYPNVNADMYREAMNPKHVAISLTGEPTLYPRLDELIEEFHKRNITTFLVTRGIRPEI
LANLKVEPTQLYISIEAFDEYSYMKFNNPISPILWKKTLESLDILPSFTSPTVIRITLVK
GFNMNTEAVEKWAKMLLKACPTFIEVKAYMHIGMSITRLSRDAMPSHSEVKKYAKMLAEE
IGYSIASESRVSRVVLLSRLEKPIIRYGNPPINWYDMETVDEKLDEYGSVQEII
>A0A1G4GYJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSKLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSTHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEILSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>A0A2I3S3B1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pan troglodytes|TrEMBL
MKLSVCVILNLDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKMQGFATV
LAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVVTYTDGLPTESAEWFCKWLE
EASIDFRFGKTYLKGMRDAVFGLGNSAYASHFHKVGKNVDKWLWMLGAHRVMSRGEGDCD
VVKSKHGSIEANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQ
EQDELHHRDTKEEEPFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEE
KSGLFRNMGRNEDGERRAMITPALREALTKQGRGACYKHTFYGIESHHCMETTPSLACAN
KCVFCWRHHNNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVK
HCALSLVGEPIMYPEINRFLKNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALAVKQQQTVYRPTLVKAWNMDELQAYVQLVSLGNPDFIGVKGVTYCGESSASSLTMAH
VPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDYNCFQELIQ
EYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKNKSKAISGC
>A0A1J4XT79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG1_02_33_12|TrEMBL
MSPELKALLEKQHYCFSGEHSAVKICTWTKKSLLDENVCYKEKFYGIRAHLCCQMTPSVG
FCTNQCIHCWREMEYTAGVKMNGILDEPEEIIKKSILCQRKLLNGFFGNEKANRKKLNQA
QEPMHFAISLTGEPTIYPKLSELISELHKLGKTTFLVTNGQFPDIIKSLKELPTQLYVSV
SATNEQDFKKFNKSCFKDGWKRLNKTLELMPELKTRTVIRITLIKGINMKDEKAYAGLIK
KAGPMFVELKAYMFVGSSRKRLLESNMPLHEEVKEFAEKVAELSGYKIIDEKKESRVVLL
AKKDYKDRIMRFD
>A0A815ERB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTVDLYILAAGSALTGLVFYFFAGAEWSLWHLFTIPLYTFVFIVFLSLSIIKRFKSSSKP
SESLTKIIPQEKNGITIVFGSVKGNCRTFAQSTYDKLSNELNCQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDGTPPPSAKWFVRHLQEAATDFRVSKNELEKLTYAIFGCGNS
FYDDNFNKVATELDRCLSELGAKQFIPTELADENSGKSIYGGLEGHYSKWSSQLKSAFQS
PKTEKCDCSNENSVNCCQSSTNNDHSIEKKQNGEQSRIESDDDDEGGGCKDGDDDIMDLE
DMGDYMETHSPNKTAKGPPKEMITPIIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVDGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A7K9JNG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicaeum eximium|TrEMBL
LDVSMDTWSYFHTCLVSLWLHRFYIYSAVAFGISLLIVIQFTTTRTKSKKSHGNPSSPEG
TADKLRNGCAPPQVQEVHVAGVKIFYGSQTGTAKRFAKALAEAVASLNLSVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGHSAYVDHYNTVGRRMDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TQLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSDHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNVHGVNHSGYHLVYFVCQFLQAKLSCLII
CALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCAL
SLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLR
RIDRPLFKDFWQRFLDSLKALAEK
>A0A4W6CWI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MDNYVCTVSYFMSIWHNRLYLYSAAALVFGSWFAVKMALKKKSFSKDIGPWVYKTMKKNN
NCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDPDDQLADE
CTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYV
GHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRLQALAK
GEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAEELIESSSDEDESGLQDEKKSGSVVDMED
LGNIMNSAKKSKEEGRGDGQMVKLSKLNGVKKIEDEGERREMITPALREALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWRWKMDPAEKILQDAVEKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPE
INTFIRLLHSHHISSFLVTNAQFPQEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFW
PRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSA
SSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYE
RFQELVQAHEESGGQQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A1D2MC02|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orchesella cincta|TrEMBL
LLITWRQLVSGSGDSDEADVLVPTDHRVAQGPKRLIRVYYGSQTGTAKGFAEQLFKDLEK
LKEDVNCEELSLHNLSSVDADSLSDFNKLATPEKIPVAIFSWRHMRMERHQIKCSGLRNQ
LKTTLVTSVFLKPSLKMFTMSFSVLEIHCMKAAAELNDSLNQLGALPILALTKGDENPLT
SEFGSLVADFNMWKRRLLRAMLSANELPSSTESNSETQELIESSSDDEQDDDDDDIPGKD
KKEPKNNDSQSQVRQRKPLKPGSNGTFEKKSLAQNGSNGGVLDLEDIGTVVKAARKKVAQ
EKEERYNGILKEMVTPDLRKALTKQGYKIVGTHSGVKLCRWTKSMLRGRADATSTHFTEL
RAIVVWKRLQVWHVPTSVHHSNPVGTEWKWQMEDPNTILDGMLQNHYKMINEFKGVPGVM
QHRLDEGMQARHCALSLVGEPIMYPEINRFVRLLHEKAISTFLVTNAQFPDAILNLDPVT
QLYVSVDAATKESLKKIDRPLFRDFWERFIDSLKALRDKKQRTVYRLTLVKDFNVTELDN
YAKLVELGNPDFIEIKGVTYCGTSKASTLTMENVPWHEENLCNTYLPDYQLACEHEHSNC
VLVAHKRFLIDNEWHTWIDYDKFHELFKEYKSSGTSFSAMDYAARTPDWACYGATERGFD
PVETRWQRKNTKKEIGVAKHDSIGTFQNG
>R7PSB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter smithii CAG:186|TrEMBL
MSLNKKQVEKLESSGYRFVGSHNHAAAKICHWTKQSILDKGVCYKEKFYGIESHRCLQMA
PAVPNCQQKCEFCWRDLSYTQTQWEGEYDDPKTIIDEAVKAQNNLLCGFFGNDKANKEKL
EESKTPTNAAISLAGEPMLYPEIDELIAEFNRRNFTTFVVSNGQCVDKLKNLENEPYQLY
LSLDAPTKKIYNDVCQPQISEGWDNLNQSLDTLASFNSRTCIRTTCVKGRNMTNPEKYAE
LIKKASPDFVEIKAYMCVGSSRHRLTPDNMPTFDEVKSFAQKIGENCGKKIVNESEVSRV
VLLQ
>A0A1A8D9N1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius kadleci|TrEMBL
MLRLLLFLSHITAHAASSDTNAQQEAPRPGESYLLWVWTNRLYVYSAAALVFGTWFLLKV
TQQEKHTDSAGPSCTSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVD
MKNYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAW
KVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTPQDASAEVDRIESSSEEDESGLA
DERTSGAVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGERREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCAL
SLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
KIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEV
KGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKV
DGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQR
RNRTKDVSGC
>A0A421JWX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spathaspora sp. JA1|TrEMBL
MLRRPATKIRLSPEDILEYDESLQQEQLQLQQQQQQQQQREEEQYKQQHHPSSILQEQIS
GNDFLSINYKPGSSSSGNNSKPDNQTRDERIGVRRWSFVLATIVLSILYNPVNNNIKEDK
VETSSSSESSRIYEVDFTSTSFTSSSFVPTSSPTTSARRSRAKRSPKVFKAKKPVIDVQP
QLSRTLVDLPKQAQIYVFYTTLTGSSHRIAKSLVTKLESIGLQHTPKMLSLDDDLDDLEE
YFLRTPQEQDEQVKNVYLLVLPSYETDSPIDYFLEHLQDTYQDFRVDKYPLRNLLGFAVL
GLGDSESWNGDKFCYQAKLADRWMGKLGGRRLFPVGTVCMKHEGEQKAQEWIDNFTELLL
DEEPFYIDENDSVDDSDNEEDSEGVTDSETLVDVEEMGNIIRKTQGSSEVETKQMVAKDS
PTFKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSN
KCVFCWRHGTNPVAKSNWRWEVDPPEKIFNGALAGHYSKIKQMRGIPGIQMDRFQEAFQV
RHCALSLVGEPIFYPHINEFVGMLHQQHISSFLVCNAQHPDNLAKLNKVTQLYVSIDAPT
KTDLKKVDRPLNSDFWERLMACLDILRTTQAHQRTVFRLTLVKGFNMGDIESYADMVERA
MPSQIEIKGATFCGSSNGNGNPLTMQNIPFYDECKSFVSALNQELQTRGLDYDIAAEHAH
SCCILMAQGKFKINGKWHTHIDYPKFFKLLESGEEFVDVDYIKETPEWAVWGSDGAGFNP
EDTKYDRKAEKLKKKIEREEAAKIEVVV
>A0A2D7BQ67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVVDNDQENLIQIKPAIAAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHQF
YGILTHRCMEFSPAGMYCENRCVYCWRPMEFYDAMKMEPEQVAEPEQILRKLMGERKKLI
DGFYGDSRNDKQRLDESLLPTHYAISLSGEPTMYPKLPELIKYLKSLKATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFIKINKPKYDDSWERWNRTLDMLKDLDTRTV
LRITLIRNYNDQKEMIPAFADMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMSEVKKF
SEEIAKQSKIFSIMDESLVSRISILQNNERFIDRYISAYANTN
>A0A2V3HR69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thalassarchaeum betae|TrEMBL
MEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLINDRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLHKIDDDPYELFLESVRGHRRLLTGYGGNPKADPEKFREAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIERLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDKAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPDFIEAKGYVYVGNSRNNLVIENMPSHQDVLDFSHRLAPLIGREVLSDRRESRVALIGK
EMIPITLPEKVRELPRDLGIAKPQRYVLPQA
>A0A482WMT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Laodelphax striatellus|TrEMBL
MIIYFELLISVVIPFIVGVVSIFFFVFYAKKEKFSDEITSTPGTNLVVTSTSFTEKNISD
SKINKNSPETVANSFCNTENCCSNQKDASNVSIGTGKLLSVIVFFGTETGNSKALALKLS
KSITQIPVQVKNLQGLDAEDKVLEQLNTNTLCIFLLPTHSGGKPPKSAEILCNWLYESTN
DFRVEKTLLKGLKFAVFGLGNSQYSDNYNVVAKKVDRELADLGAERLIELTLGDEDETAS
NNGGLEEDFNVWLRQLANVVENWLNNRTCTKTENFQNPKSLTNGDAESSSESENDDELMD
MEDIGVMMGKQKQKADEPHGKEMITPKLRQVLTKQGYRLIGSHSGVKMCRWTKSMLRGRG
GCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGTEWRWKQDSAADILDGALNN
HYNMINQFKGVPGVIQARFAEGLEAKHCALSLVGEPIMYPEINKFVTLLHDKGISSFLVT
NAQFPEAIRNLSPVTQLYVSVDASTKESLKKIDRPLFKDFWDRFIDSLKALSEKGQRTVY
RLTLVKAWNFDELNNYAQLVDLGNPDFIEIKGVTFCGDSNKVNSLTMQNVPWHEEVVSFA
RKLVDLLPNYDIASEHEHSNCILIAHKKFFVDDEWWTWIDYDRFTELVNKFYKSEGKHTF
TALDYMAKTPHWAVFGASEKGFDPIETRWHRNSKQKDLSGC
>B6YVS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus onnurineus (strain NA1)|TrEMBL
MAITFKSNPNMPGEIARLFKKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPGPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTAPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKITRTLELMNGLPTRTVIRLTLVKDE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKTFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A5C6GJT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium rileyi|TrEMBL
MSXICEKIDPLQGIFGGRPRARLDGIIELWHDHRTPIIFCALIVLVVIRFFIHRIEETEP
LKALPKQFEQKIDPLTAAKKSSGVNSENTIAKSNGPRRIKGGITKKPSTGKEEQFDKSRP
IKVSVFFSSVTTKTERIAQQYLNALGKVADRLSRETPREFLKPELYDLTEIDFEDFFVSP
AKTAENAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLASLLGYSVFGFGDKE
GWPDETEGYCFQAKEVDRWMSKLTGRKRAYPIGMGDMKSDHVERFEEWALGIQEVIAYVA
SSGSLGDGVPGSGDAVESDAEDVAEEDDGEVLFEDDASGDNGESPRPLDDVEDLGRMIRT
SDGNGTPAKGKKAPLAVDFTSYGSSSTKKRTPTAPVIKEMVAKNSPTYAALTKQGYAIVG
SHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPH
INEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFW
ERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVCDFVKALEQRLKARGLKYGIAAEHAHSCCILLASERFLVDG
KWHTHIDYKRFFELLEERGPDGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIE
NVVVREAPPPESW
>L5LGP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myotis davidii|TrEMBL
MCVILNLDPSLDTWDFSPLISLWISRYYIYLGFAFGIGLWICFQIVTRKQDKNSQEKSIP
KAAQDLMTNGYSSLHKKEVFVSGVKIFYGSQTGTAKEFATILAEAVTSLYLPVAVINLKE
YDPDDNLVEEVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASNDFRFGKTYLKGMRYA
VFGLGNSAYASHFNKVGKNVDKWLWMLGARRVMTRGEGDCNVVKSKHGSIEADFRAWKTK
FISQLQVLCKGEKKSCDGSCKKGKCESNQRSSEEMELGSHTQDGLQQRDPEEEEPFESSS
EEESGTEDHQSLTSVVDVEDLGNIMNHVKKEKREKEQQEEKTGLFRNTVKNEATERRAMI
TPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCIFCWRHHTNPVGTEWRWKMDQPEVILKEAIENHQNMIKQFKGVPGVKEERFKEGMT
VKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGH
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVDLIPDYEIACEHEHSNCLLIA
HKKFKIDSEWWTWIDYNRFQELIQEYEDSGGSKTFSTEDYMAKTPHWALFGANERGFDPK
DTRFQRKNKSKDISGC
>A0A0U3F365|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignicoccus islandicus DSM 13165|TrEMBL
MKADAIAQIMDRLRKAGYHIVGTHSAVKKCHWTHVALTQRRFCYKCKFYGIASHRCLQMT
PAVIWCWLRCLHCWRAEPGDLGVQWDDTGLPVVDDPEFIVEKTIEEQRKIISGYKGHPKV
SPEMFEEAMNPKHVAISLSGEPTLYPLLSDLIEEYHKRGMTTFLVTHGVRPDVLAELNPE
PTQLYLSLEAWDEKSFKEFNRPILPGLWNAVLTSLDLLPSFSSPTVIRVTLVKGFNDKPE
ALKGLAKLIERGYPTYVEVKAYMNVGYSRYRLTKENMPRHNEVREFAEKLAEEIGYKVLD
EQRSSRVVLLSRLDKPIRVGEGCPGGNAGEDLPEGEEYRMSEKIK
>A0A0V1EXU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LLINNTKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIV
ILLYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGH
LENEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAY
RSTFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFS
SVHDNKRVSVWHDENENSSDAEDAENSANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQGY
HLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSN
PVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPI
MYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLF
RDFWQRLMNSIDILRDKKQRTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCG
DSKNSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTW
IDYEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A0V0YDI3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMLERILHVFFPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSV
HDNKRVSVWHDENENSSDAEDAENSANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQGYHL
VGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPV
GTEWKWKTDSAEKILFDSLEGHKKMVYLELKMLDLRNRQRFVIAHCLWLESQSCTPISMN
>A0A093GDY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dryobates pubescens|TrEMBL
LDASVDAWNFLSTSLVSLWLQRFYIYAAVALGLSIWLIIHFTTTTGKKEGKNSKGSPTAL
EGAEDKLVNGSATLKAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVTPLHLPVEVISMGD
YDPEDCLSEETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAASDFRYGKTYLKGLSYA
VFGLGNSVYVDHYNTVGRKVDRWLWMLGASRVLTRAEGDCNVAQSKHGSVEADFEAWKTK
FLSRLQALCRGEKQPCSGKCKKGKCKPRGKQSKESSDQECGASESETAEAEEVFESSSEE
EAGAEAAGGTDSVVDVEDLGKIVSHVRRTKRDPELQEGDGGMSLTQGSIEKKEKGEKREM
ITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHSFYGIQSHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFKGVSGVKAARLEEAM
TVKHCALSLVGEPIMYPQINQFVKLLHQHGISSFLVTNAQFPEEIRNLGPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELRAYADLIALG
KPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVQELADLLPGYELACEHQHSNCLLI
AHQKVRL
>A0A818ZIU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood1|TrEMBL
MTVDLYIFAAGTALTGLVFYYLAGAEWSLWHLFTIPLYTFIFIVFLSLSILKRFKTQLST
KIISQDKNGITIVFGSVKGNSRTFAQLTYDKLLNELNRQVILQDLNDITDPEEFLQIQVK
NQRILLIFISTYEDGIPPPSAKWFLRYLQEAATDFRVSKNELEKLTYTIFGCGNSLYNDN
FNKVAKELDRCLLELSAKQFIPSEYADENTVKSIYGGLEGHYSKWLSQLISNLQSSKVDK
CDCSNDKSINCCQSLTNNNHSNENVEQLRIESDDDDEDGGGCKNGNDDIMDLEDMGDYME
THSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENHYKMINTF
KGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHSKKISSFLVTNAQFPNEM
KTLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLDSLRALKDKGQRTLLLYDYDKVE
LANMNRLFYQPHQAGLSKVEAAADTLRFINPDVIIESYNMNITKVENFPLFMEKIRTGNK
NNSGHVDLVLSCVDNFGARMTINTACNELDQTWMESGVSENAVSGHIQLIVPGKTACFAC
APPLILASNIDESTLKREGVCAASLPTTMGIVAGFLVQNTLKYLLKFGRISNYIGYNALD
DHFLILTLKPNEDCDDSYCRKRQLEHQLHPVVIEENVPTINTEVVHESNEWXLNLLKSIG
DHGSKPGEFNVPWGITTDSFSNMYICDQMNNRIQKFDADGRFLLEWGYEGENPGQFYYPH
FISVSGNRVAVSDQLNHRIQVFDCFGNYHYKLGEVGNEPGQFSCPFGVCIDANGHLIVAD
HDNNRVQFFDANGDIKLILDQEVNPLFNFQGVHGLALTHDGGLLITDYKRNGKHRLFIFA
>K0SVB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thalassiosira oceanica|TrEMBL
LAACYACRVSARAAYPAGTRQRAAAAAAPPFSSGRQRSQRQRQRNQSKPIGRRDAAADDA
DEGTTLKQWHRLAATRPRSSPPRPRPPSPRRATSTGAPAYDGSRGGGVRRPSASASSRGR
RRDERGTLGGRGGRRGGDECPPGMADVISVPAGGAAAERQYARVLSPGTVTVAYSSKTGT
CGGYASRLRDSIAEEIAGSNWGRRRTVQLLRVEELDWWDELVNDEDAEQDGGNNKGTASS
PSSAPVLLLVLPTWTGGTLPPESSVLLENLREIATDWRVAPEPLRSSDPGRQLKVAAFGM
GSSAYDASTVGRPAKDAFASLVGKLGARPLVGNKVVSKTAGGRKGKSLMVGDAEVGDAGE
VYEKWAEGVMASIFPEEEKKSRKASKESETTTCGDGKNESDCACKSQSKPKNDDAGCCSA
EKQSDEETDSLSADEDDGYDSSDDIVDLEDMGDIMKSQRSSKSKEPVEMVTPRQAKALKK
EGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTHYGITSYQCMEATPSLACANKCVFCWRH
HKNPVGREWRWKTDDPAMIVEEAVNTHVDMIRETRGIPGIRMDRWEEAHTVRHCALSLVG
EPIMYPRINELLEELHDRDISTFLVTNGQHPKAIEDLIPITQLYVSVDASNPESLEAVDR
PLFSDAWDRLKSSLSCLRRKGQRTVARLTVVKGWNSDDLGGYARLVALGRCSLVEVKGVT
FCGKSDASNLNMTNTPWHHEVVEFTRKLKVELDAIREEGGDDPLPEYDLACEHKHSCSVL
LARVDQFAVPDPSDPARRKWRTWIDYPKFQELASRHRSDQTFTFGVEDYTADTPDWAVFG
ADEEGFDPTDKRHRKKSKHPMYARFDGSGVPTHDTFGEPLGEDEMEILRERMDERKRELG
DATTVTELRSGEKVLEDPSLMFRGLVVTR
>A0A1J4LUH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba sp. SSL1|TrEMBL
MSDSADAGVDVEVGADADADSGTDDGNRDGGPAQVSSPNYHSENHTAAQTCGWTANALRG
EGRCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDGVEWDDPEAVVDASI
DLQKRLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFL
VSNGTRPEMLRECDPTQLYVSVDAPERHTFDQVVKAVEDDAWDRLLETMEVLREKEETRT
VLRTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVVEFA
ESVAEYMPEFTECKGVPSSRVALLSKTSDTWVPKLKKGSEFWARDPVTGD
>A0A1R3HXU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corchorus olitorius|TrEMBL
MAPSSLSTRLTLLALLSGATFYFLYKSRRRLIPLKQLSLIPNPRKGKLFFISQTGTSKAL
AERLLKLLSSNNIPFDLVDPQNYEPEDLPKESLILIVASTWEDGNPPQNSKFFVNWLAEI
STDFRAGNLLLSNCKFAVFGVGSRAYGETFNAVARDLGKRLRGLGATEMVAVGEGDVDGD
IAGKGPSRKKSVNVAETNGKPDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVDT
AIDLHTKMIKQMKGVPGVTQERLSEGLYPRHCALSLVGEPIMYPEINMLVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALNEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFNIGKPDFVEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALALKSYGEYEVACEHAHSCCVLLAKTEKFKVDGQWYTWIDYEKFHDLVASGKPFK
SEDYMALTPSWAVYGAEEGGFDPDQSRYRKERHHKPKTTA
>A0A4Q4X661|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. CRB-8-3|TrEMBL
MSTTFWESVGDGNRGLTGILELWHLHRASVLGTTTAVLFVVWLYLQLSQGQKRGAGSPKL
ESGKNLPAELVAEEKVSLSAAKESSSGPRRIKGELRKADGPKSAVQLDPQRRVQILVFFS
SLTGSTERTAKQFTATLEASLLDQTSESDQVFLKPQLLDLTQIDYDEFFISPPKSAEAGQ
PVDYFYLILLPSYNIDTINDNLLEHLKETHNDFRINKASLAGLLGYSVFGLGDQEGWPTE
EEGFCFQAKEVDKWMAKLTSRKRAYPLGTGDSKRDLKERLAEWTEGVTEVVRQTAKTGCL
GDGVPGSGDAVESDDEYVSGEDDDGEVVVGEPVQPKKTKKSTGDIDDVEDLGRIMKTSRA
DANDATGRVPIAVDFTTYSKTSMKPPQTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKIC
RWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDP
PDLIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALL
HGERISSFLVCNAQHPEQLAALKAVTQLYVSIDASNRESLRRIDRPLPRDFWERFLRCLD
ILRERRFRQRTVFRLTLVKGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSSGGRD
GGLSMANVPFYAEVTAFVEALDRRLRERGLGYGIAAEHAHSCCVLLASERFRVGGRWHTR
IDYGRFFELLEERGPDGEWTPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIAA
>A0A545A4I0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Golovinomyces magnicellulatus|TrEMBL
MTDISSGTVDDTSRVGLIQGSDDKKSKIENQKEKKKGKKDKPYATTDKVIRTSATLFKSL
GIVMISAGWNFKNLWSLETKTGHGQHSNSVDPVELWHIHRFSIFLMILTILVSLKLLFYL
RATRENSPPTASNLNTVSIEDSKNSSEKGHTSVQGRVPKRIIGGLKKSRVPPRTENTSDQ
KITVLIFYSSVTGTTKRIAQDFTESLARNSEKLDDSERNIFLKPELIDLAQIVFDDYFLN
IGLSNPNVGHFYLFLLPTYNIETILDGFLEHLRETHNDFRIETAPLSPILGYSVFGFGDR
DGWPTEKDGFCSQAIEVDKWMARLTEGKRAFPLGMGDIKIDAIENLEKWKEGIEDVLRHI
ASTGSLGEGVIGSGDAEESDAEETDYDQGSNRKLKQSHRTKKRIEKETQNDLEDIGSTVN
NKSTDNSPQEINFTHFGSKSPPIIKEMVPKGSPTHKALTKQGYSIVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELIF
SGVKAGHYQKIKMMRGVPGVRSERFSEAMRIRHCALSLVGEPIFYPHINEFLAMLHAEHI
SSFLVCNAQHPDQLASLNHVTQLYVSIDASNRESLRKIDRPLHHDFWERFNRCLDILRHR
RFEQRTVFRLTLVKGFNIDDEIVGYANLIEKSLPCFVEIKGVTYCGTSSAAGAGLTMQNV
PFYDEICTFVESLDKELNRRGLDYGIAAEHAHSCCVLIASKRFQKHGKWHTRIDYDKFFR
CLESGEKFMPEDYMGPETPVWATWGNGGFDPRDERVFRKGKNKVPLPLIESKSGALSIEQ
>A0A7L1NF71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopomastus cyanomelas|TrEMBL
VDVSMDMWDLFYSCLVSLWLHRIYIYSAVVLGISIWIVTQFISTKTGRKGKKSNGNPAAS
EGVEDKLENGYTTLQPKEVYVAGVKIFYGSQTGTAKRFAKALAEAVISLNLPVEAISMGD
YDPDDCLAEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAASDFRFGKTFLKGLRYA
VFGLGNSVYVDHYNTVGRNTDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLGRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSGHEHGASEYENTEAEELFETSSEE
DADAEEAGGTNSVVDVEDLGNIMSRMKKEKREHELEDGSVGMSLTGDNTGRKEEAEEREM
ITPALRGALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHCCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPERIFQEAIENHQNMIKQFKGVSGVKADRFEEAM
TVKHCALSLVGEPIMYPKINRFVKLLHQHSISSFLVTNAQFPDEIRNLTPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPNYEIACEHEHSNCLLI
AHTKFKINGQWCTWIDYKRFQELVQEYERSGGSKMFSAADYTARTPHWALFGSRERGFDP
LDVRHQRRNRTRDISGC
>Q46DR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina barkeri (strain Fusaro / DSM 804)|TrEMBL
MRKMPLEEKKENTGENFPEAQKKNRKEDTASLPFDIPDFKTLLKKQGYAMAGRHSAVKTC
LWLRHAMNDQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPE
KIVEESIACQRKLITGFGGSPNAIKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPEMLAQVSPSQLYMSLDAPDLETYLKVCQPKSPALWEKINESLSLMK
QKKSRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSQELAKYLGYEIADESEISRVVLLSKDGRKSPVNGEKISR
>A0A6N0NUE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metallosphaera tengchongensis|TrEMBL
MAVKESYRIDTLSKIRNEMEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMTPVSTWCWFRCIHCWRLEPEDIGLEWDETKMPYMDDPEYIAERSIEEHKRSVSGY
LGRTGVDQTKAEEAMRPSHVAISLTGEPTLYERLGELIREYHKRNITTFLVTSGVRPDIL
ASLDEEPTQLFVSLQAPNEEKHKLINRPVVANSWNLVMRTLDILPSFSSPTVIRMTMMKG
VNMSVNDAKDFAKLIEHSKPTYVEVKAYMHVGPSTYRLTKDAMPNHAEIREFAKELAKFS
NYSIISEHPPSRIVLLSALDRPMQIGNAWTEKWDWRTQEIQDDVNGEYREAEMGCTEEGE
GRNHE
>A0A3P8XT50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
MFLKHLSIFTLPQTIALETKAKMLQGSTLLLLDFITDILCADIDGKKTVRSTLESYILLV
WQNRLYLYTAAAVFVGIWFSMKIALKKGFANELEEEVKTLGIAAKVIDMKDYDPDDRLAD
ECSTKSICVFLLATYTDGQPTENAKWFCKWLEEASTDFRYGNNYLKGLRYAVFGLGNSVY
DSHFNTVSKNVDKWLWKLSGVRVLSRGDGDCNVVKSRHGSLHSDFLVWKTKFLSRLQTMV
AGPKACRGKCKTGGSCNNRKKPQKTDDEQAAPEQLSSEEELVESSSEEEAAGTGPDEQHP
GSVIDVEDLGNMMNGMRKAKRRVEGQVDEQMKLPRLNRQKKAEEEEERREMITPALRVAL
TKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDPPEKILLEAVENHQNMIRQFRGVPGVRLERYQEGLKVKHCALSL
VGEPIMYPEINAFLCLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKI
DRPLFKDFWTRFLDSLKALGEKRQRTVYRLTLVKAWNVDELKSYSELISLGQPDFIEVKG
VTYCGESSASSLTMANVPWHEEVIHFVQQLVDMLPQYQIACEHEHSNCLLIAHTKFKVDG
EWWTWIDYERFQELVQAYEESGGSQTFSAMDYMAKTPMWALFGASERGFDPTDTRYQRRH
KTKDISGC
>L0KTA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomethylovorans hollandica (strain DSM 15978 / NBRC 107637 / DMS1)|TrEMBL
MSSQEYNFSDLTDLHSLLKKQGYNLAGNHSAVKTCLWLRRAMREEGKCYKASFYGIESHR
CLQMTPTLMCNQRCLHCWRPVEVDAPAPEEWDSPSEIVGSCIKSQRKLISGFGDADRREL
WLEGNEPRHVAISLSGEPTMYPYLPELVEEFKNQGLTTFVVSNGTNPEMMRLIDPSQLYM
SLDAPNEETYNKVCRPRSTQLWNKLNESLEILKNKETRTVIRITLIKGVNMFQPQGYADL
IRKASPDYVEVKAYMHLGFSRNRLPREAMPSHEEVLNFSRQIADYLGYVVADDVEISRVV
LLSRDGYVSFLK
>A0A1B8AFI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium poae|TrEMBL
MDWANHSSPSRLDLFVDELVDVWHLHRTPILFTGCIILVAIRIYFQFNGQKTEIVAFKKA
YEEPVKPKVVAEEVKVEQVQIEEKTPTTEPVEEKKNAKSQGPRRIKGGLARKPSKKTDEE
KDLTRPVLPLIFFCSVTTKTAKIAQEYVEKLGGKLDELSKQSGRQYLKPETRDLTEIDFD
DYFLTPYKAHGDVDLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGNLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKTPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A2H9LQQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon CG07_land_8_20_14_0_80_38_8|TrEMBL
MNREVYTKKRYNLVGKHSAVKLCNWTRRSLTGKGECYKEKFYNIKSHRCLQMTPAVAWCE
HSCLFCWRPTEFTSGTSMENVELDEPEIIVEKAVEAQRKLLSGFKGNPKTPKKIFEEAVN
PNQAAISLAGEPTLYPKINGLIREFHKRGFTTFLVTNGMNPEVLDKLKPLPTQLYLTIPA
GNEEDYLKITRSAFGKKGWDNLMKSLKIMKKLETRRVIRLTLVKGLNLKNPEEYAELVRK
ANPDFVEAKAYMHVGSSRQRLEEFHMPSLSEIRQFSQRLAQILGWKIIDEHETSRVCLIA
KEDYNWRFL
>A0A0M0BNL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|miscellaneous Crenarchaeota group-1 archaeon SG8-32-1|TrEMBL
MLYKQKYHLVGNHSAIKRCRWLYNSIIQNRVCYKQKFYGIQSHRCLQMTPSVFYCSLGCI
FCWRAQNGDHNIRWDETKLPTWEDPETIIDGCIKEQKRILTGYKATPNVDHIKRIEAHTP
RHAAISLAGEPTIYPHLDGLIKDFHRRNFTTFLVTNGTNPNALSKLIEEPTQLYVSVSAF
DKDAFSKICRPQSNNSWKKLNETLGLLPSFKCPTVIRFTLARHLNLEYPKRFAELVKKAN
PTYLEPKAYMFVGFSRLRLEFSNMPTHEEIKKFGAQLSSELEYKILDESPDSRVVLLSRL
EKAIKLA
>A0A448ZST0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudo-nitzschia multistriata|TrEMBL
MSRNSSQNQVILTTAVSLTLVALGTFWYRRQGTDDSAGANPDPEREGRKQERQGQHPRVV
RRTQRNAAAIEYDDNEEKNEERGRPADGIDATASGGAAKPQRASFDAPVLEIQTRPIDTI
PEDEKEEGKGNYRRVLAPNTITIAHGSVTGTCSKLATDLLACLREKNLDHDRTIQMGSLE
EWDWWDELLNSEEDENAAKKSKKKNAVEPNPPVLLVLLPTHHGGSWPHTATCLESALQDL
KNDWRIEKRPLKNKLQVAVMGMGCSDYGDDTMGKPAKEAFIGFRTLGAKVFGKQVRVGDD
ATGNQDRVLQAWIYHDILPKLIVDDEEDEAEDERNEEPEVTDMEDLGTIMESSENDNEGE
VKSSEPREMVTSTQAKSLKKEGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQ
CMEATPSLACANKCVFCWRHHKNPVGKEWRWKTDDPNFIVDEAVKTHVKMIKETRGIPGV
NVQRWQEAHTVRHCALSLVGEPVMYPRINELLEDLHNREISTFLVTNGQHPKAIESLIPI
TQLYVSVDAPTPESLIEIDRPLFSDAWERLQEALTLLKHKGQRTVARLTVVKGWNSDEVE
GYAKLIALGKVSLVEVKGVTFCGKSDASNLNMSNTPWHHEVVDLVKNLKVELDKLRLEGQ
DVPEYDLACEHKHSVSVLLARVDQFAETAADGRRMWKTWINYPKFHELARKHKEDPTFTY
AVEDYTAETPAWALFGSEEEGFDPVELRHRRKKKYPKYRQFDERGVPTHDDNNEKLSDEE
YLRLNSMMDEKIKQIGCGSTVTALKGGEKMIQDASLMFRGLVIVK
>A0A0D2IXV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinocladiella mackenziei CBS 650.93|TrEMBL
MDLGDGGATPVILADWLDRLLTSWHDGRLAVSTILVACLLIVWVRRRQVYRISPSDSSPR
PEKGDWLNQTGNDSSSTTNDERSISSKVNQLTFAQNQKLRPAAARVVAGRKPVRTRAGPS
CVQPLIFFSSLTGTTERLSKYVATSLETLTASQSTILNPQIYDISHIDLDDYFISGPKTS
GPRSDIRFFYLLLIPSYDIDTILNTFLAHLDETHHDFRIDTSPLSVLAGYTVFGVGDKEG
WPSEGREFCSQAVELDKWMAKLTGRKRAYPLGLGDVKSNVHQALQDWTSGVCDVLRELSM
TGSLGEGVPGSGDAVESVDEDESETGEAGVEFPDPRRHKRRKIATTTDLEDVGGTEGSLI
APMAIDFTTYSSPPSVPREAPKAMVPNESPTYAALTKQGYTIVGTHSGVKICRWTKSALR
GRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQMIFAGA
KEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLHGERISSF
LVCNAQHPQQLRGLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQSCLDILREKRFI
QRTVFRLTLVKGFNIEDEVEGYADLVAKGLPCFIEIKGVTYCGTSSSAGAGLTMQNVPFY
GEVVAFVEALDQALAKRRLEYGIAAEHAHSCCVLLASKRFFIKEKWQTIIDYDRFFDLLE
NGVEFAPEDYCKETPEWALWGNGGFDPRDDRVDRKGRPKEKKDMKAVVVDEKAKQGF
>W2WSX7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora parasitica CJ01A1|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A2R6PZV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Actinidia chinensis var. chinensis|TrEMBL
MPPASAARLTVIAVLSAATVYCFYKSRRLRLLKKLSSPNPNPTLAPPKGKLLFVSQTGTS
KTLARRLFDLLTSNGLAFDLVDPKDYEPEDLHKENLVLIVASTWDDGKPPPNGGFFADWL
AESSDDFRVGSMLLSKCSFAVFGVGSRAYGETFNAVAKEFSKRMRSLGATEVLPMWEGDV
DGGDLDMVFDGWSEKLIGVLKGGALENGDKSEFGGDESDFEVISSSDEEDKDENGADSGI
VDVEDIAGKAPSRKSMALDRPNGKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVKLCRWT
KSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLE
IVNSAIDLHTKMIRQMKGVPGVKADRLSEGLSPRHCALSLVGEPIMYPEINSLVDELHRR
RISTFLVTNAQFPEKIKLLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFVDSLKALK
EKQQRTVYRLTLVKGWNTEDIDAYSSLFSVGNPDFIEIKGVTYCGSSATSKLTMENVPWH
SDVKAFSEALALKSEGQYEVACEHIHSCCVLLAKVDKFKVNGLWFTWIDYEKFHDLVATG
RTFDSKDYMAATPSWAVYGAEEGGFDPEQSRYRKERHHKSSH
>A0A0F2LE30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoproteus sp. AZ2|TrEMBL
MSCEEEVVGRHHVLEGRIIKIRASTMRELIEAHYGVYGHATVELCKWTKDALEGKKSCYK
VKFYNAPAGGSHRCVEMSPVGMVCSNRCIYCWRPTEDFDSFAPDEFNVMEPEEIVRGVLK
ERERLLSGYWGHAGARARVKEALAPTHWAISLSGEPTLYPKLPELVKYIKSLPHTRSVFI
VTNGQHPEMLERLIKEDALPTQLYLSMNAPNKELFYVINVPVMNREDAWERWLRSLDLLA
AMPTRTVVRITLIRSLNYDEKYLQEFAQLVKRGNPHFVEVKSYMHLGRSTNRLKREDMLS
HEEVVAWAKALRDELERIGARFAYMDDDEPSRIAVLQNLDRYVDRWIVKPGSS
>A0A1U8KK19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium hirsutum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKFRRRCLKPLKHLPLNPNPRPGKLFFLSQTGTSKA
LSQRLLDLLSSKNNIPFDLVDPQTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMLPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A131YK04|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhipicephalus appendiculatus|TrEMBL
MFPRRFVTSLLCALLMFHTVHAKGNANEKSRSDWYPSSYTTTLCGGVLAVLFFVIAREKL
NLSKIKTQDPFKQRKRKRNGKSVKVLYGTQTGNAKILSEKLTAELDALDYDVEMVNLKHV
EPEECLLGQVKAKGLCIFIVSTYVDGSAPDEATWFYDWLKDTYADFRVHKYYLQGLNYAI
YGLGDSAYGDSYNKVAKDIDFWLSKLHATPVVPLCLNDESHDEGKYGTGKFPGWKDDILA
YLEGRPSITTQPREDQTAPEDVAYESSSDEGEPDLIDLEDLGNVRSTNKLKAQESKNVKN
GEARPDMLTPLLRQSLGKQGYRLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCM
EATPSLACANKCVFCWRHHTNPVGTEWKWNMDSPEMIVENALKNHYKMIKEFKGVPGVLR
ERLEEGLRARHCALSLVGEPIMYPKIDRLVRLLHEQGISTFLVTNAQFPDALRELGPVTQ
LYVSVDASSREALKRIDRPLFPDFWQRFQDSLSTLADKGQRTVYRLTLVKEWNMDEMQGY
ANLVALGKPDFIEVKGVTYCGDSKGARLTMSNVPWHEEVLSFVKQLVALLSDYSIASEHE
HSNCVLIGHNKFRVNGQWNTWIDYERFHELVQRFYQTGESFTSLDYAAPLPHWAVFGAKE
RGFDPSDTRMLRRSKKDISGC
>A0A1V4UII9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon PtaB.Bin152|TrEMBL
MCYKHQFYGIASHRCVQMTPTLRCNQRCLFCWRSFEHEYPGERDLLPEEILARVAALQKR
ALSGYKPSPYVTPERFAEALDPTHVAISLSGEPTLYPHLPALIDLFSREGFSTFLVTNGT
RPDVLARCRPFQTYVSLTAPDAGTYRKVCRPLEDTWEAVQESLSLLGTRRSAVRITLVKG
YNDFSPGSYARMIQDSGATFVEVKGYMFLGYSRKRLERGNMPTFAHVKEFAEHIAAACDY
EVRDENPASRVVCMGRRQ
>A0A2D4GG76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Micrurus corallinus|TrEMBL
MDTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKNHLVELNPSK
TTAAEKEQQDPSFEEVHVAGVKVFYGSQTGTAKRFALVLTKAVASINLPAEIIDMQDYDP
DDCLIDEISGKNICIFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSLYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHGNIEADFEAWKAKLLM
RLQALAKGEQKACSGRCKKGQCRSKSKVSQEAKEQETSEHVEKEEEDFFETTSEEESDTE
NGRGADQVVDVEDLGKVMDQMKKSQKDHQTNGEVPIGVGTQHGRGEDERREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALS
LVGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEVK
GVTYCGESSASNLTMANVPWHEEVTRFVQELADLLPDYEIASEHEHSNCLLIAHKKFKIK
GKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKERGFDPVDTRFQRK
NKIKDISGC
>A0A7C3XKN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaerales archaeon|TrEMBL
MLNLNKNNLAYPHLLLDLLKKQKYHIVGRHSSVKKCKWLHESLVHDRVCYKQKFYGIRSH
RCLQMTPAVLSCLTHCIYCWRVMPEDIGIEWNETFGSDWDEPEEIVEGCIREQRRILTGY
KDQVIKGKVSKEKYEEALNPNMVAISLSGEPTLYPKLGELIASFKGKGFSVFLVTSGILP
EALKRLDAEPSQLYISLTAPDYDTYQKVNRPISPRLWYSLMKSLELVKSFKCPAVIRITA
IKGINMDHPENFSKLISMSDCTYVETKAYMHLGYSMHRLTRSNMPSFKEIERFSHRLSEL
TGYKKIGSSEESRVVLLSKLKKPITFDRFA
>A0A261XXK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bifiguratus adelaidae|TrEMBL
MSFASLLSSLSNALSLGKNTACGDDCSCQELKGGHIKIFYGSLTGTAKQLAQRLAQLVAE
HPVLQQHYTTEVIDVVEYDTEDFFKETSICFFLLSNYNIESPVDWFVNGWLKDARYDFRV
DRLALQKIRYAVFGLGDSAFAEEDYMRDSYNVDKWLGQLGATRLFPAGEGDKNNDQEKQF
LAWADGILHVLSDERELAFAPNHVEYDSEGEDVSEDEHGERVRDVGAGREDGAGISGDEV
LDVEDIGKVASKIKTAVEQKSKEEEAYRQSQRQRAPNGRAKRTIGNGKEDAGWTKTPAPP
REMVSPMLHKALTKQGYKIIGSHSGVKICRWTKSALRGRGFCYKHTFYGIQSHLCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKVDDPEFILDGAMQNHYKMIKQLKGVPGVKADRFQ
DAFTIRHCALSLVGEPIFYPHINEFVKLLHQKHISSFLVTNAQFPDKIAEMDMVTQLYVS
VDASTKEALKKIDRPLFRDFWERFLNSLDALSAKGQRTVYRLTLVKDYNTEDLGNYVELI
SRGKPCFIEVKGVTYCGYSGASNLTMANVPYHNEVIGFCEDLVNLLGEGYEIASEHAHSC
SVLIASTRFKKDGEWYTHIDYEKFFQLVESNKAFTALDFMAKTPDWAVFGVAEGGFDPEE
TRWYRKQKGDIGVAEQGC
>A0A800XLU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon Met12|TrEMBL
MLKKQGYHMVGGHSAVKACLWLNRSLRDEGACYKSKFYGIQSHRCVQMTPTLSCNQRCIF
CWRPIEMAIPEHGWDDPETIVEGCIAAQMRLMSGYGGATTTNMQKLEEAKEPKHAAISLA
GEPTLYPYLSELVETFHKRGMTTFVVTNGTHPEMIARIRPTQLYISLDAPDQETYKSVCN
PVRDTWNDINESLEILRTKDIRTAIRITLVDGINLKGPEKYARLIEKGEPDYVEVKAYMH
LGFSRQRLPRTAMPSHKTILEFAGRLAETLGYPIVDDVEISRVVLLSKVNEAKRGCETSR
QLNPCRIIS
>A0A075GGA5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine group II/III euryarchaeote KM3_155_G07|TrEMBL
MQSPPVGSPVTLNEGGSLIEPEIAAKLSKQSYQLVGEHGGVKICHWTKENLKNDRHCYKG
TFYGIKSAGCMQMAPNVDTCNLACTYCWREPHSETLNRIDDDPEHLFYESVRGHRRLLTG
FKGNANVPFERWEEAQNPKHVAISLNGEPTLYSRLGEFLEICHDHGVSTFLVTNGSLPKV
IENLDPLPTQLYVSVDAPNKKLFNKLCKPKFNDNAWEKLEETLALLPSLDTRTVCRHTLI
KNHSLGHHEDYARLDNIADPMFIEAKGYVHVGHSQNNHVIDDMPTHTEIMEFSHNLAPLV
GREVLSDRRESRVTLIGREMIPVTLPVATREFPEDLGIAPPQNYRLPTV
>A0A2I0NMQ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon HGW-Methanomicrobiales-6|TrEMBL
MHSEACKALKKQGYQFITPNSSAAVKPCMWNKRALRGGEMCYKAQFYGIESHRCVQMTPT
LKCNQQCLFCWRSFEHEVVEEEECPPDVIIENLRRVQKKALSGYKVSPYVAPERFAEALD
PTMVAISLSGEPTCYSRLPELVDGLNAEGYTTFLVSNGTRPDVLARCRPYQTYVSLDAPD
RETYLSLCRPREDYWDRIHESLAGLRERRSAIRTTVVRGYNDFSPEGYAAIYQDSGARFV
EVKGYMYLGYSRNRLQREQMPEHREIRAFSEKIAEHCDYVIRDESPVSRVVCLERKI
>A0A8C3PWJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chrysolophus pictus|TrEMBL
MDMWNFFYTCLVSLWLDRIYIYSVTAFGISLWIAIQFFTTKAKRKDENSNGNLVSSEVVE
GKLVNGYATLQPKEVYVAGVKIFYGSQTGTAKRFARDLADAVTCLNLPMEVINMGDYDPD
DCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFEAWKSKFLSC
LQALCRGEKKPCSGKCKKGKCKSQGKQSKEGSNHERGAPEFENTEAEELFETTSEEEADT
EETGGTDSVVDVEDLGKIMSHMKKAKRERELEDGDAGMSLLGETSGRKEAGERREMITAA
LRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILREALENHQNMIKEFKGVTGVRAERFEEAMSAKH
CALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKPDF
IEVKGVTYCGDSSASSLTMANVPWHEEVVHFVQELTQLLPDYGIACEHEHSNCLLIAHKK
FKINGDWCTWIDYERFQELVKAHVDSGGTQTFTATDYTARTPHWALFGSSQRGFDPLDVR
YQRRGKVRDVSGC
>Q8TZ84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)|TrEMBL
MLHADVLKVLRKQGYGLVGKHSAVKPCHWCREAIKNGRHCYKAKFYGVESHRCLQMTPTV
AWCQQRCVYCWRPVELTVGTHDVPDPDDPDLIVEESVEQQRRFLQGYGHLEGEARKRWKE
SLEPRHAAISLAGEPTLYPRIGELIDAFHSHGFDTTFLVTNGLRPDRVEELEREPTQLYV
SLDSPNEELHRQINRPTIPDSWDRIMRTLELLNSLSCRTVIRITAIKGWNMEGTAEEFGE
LLADVEPDYVEVKAFMCVGWAAFRMSPDNMPSHEEVRKFAAEIAEHAGFELVDESPPSRV
ALLSS
>A0A3Q1HXI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anabas testudineus|TrEMBL
MQSFFAVILLFIRRVSTSDTKDPQDVHSSSYFMSIWHNRLYLYTAAALFFGIWFALKISL
KKKNSKDVNSSVNKTEKSSERSDKQKVVHVSGVKIFYGSQTGTAKAFANELSEEVKALGI
PAEVTDMKEYDPDDQLADECTRKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGK
TYLKGLRYAVFGLGNSVYFGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSVQ
ADFLAWKVKFLKRLQALAKGEKKKCSGNCKKGGSCKNKRKDRKVEEEGEKAAQQNNSSEE
DLMETSSDEEGSGLEDEKKTGSVVDMEDLGNIMNSVKKAKSKEDVQTDDQIVKLSKLNGV
KNIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPADKILQDSLEKHQNMIRQFRGV
PGVKPERYEEGLEVKHCALSLVGEPIMYPEINAFIRLLHSHRISSFLVTNAQFPQEIRSL
VPVTQLYVSVDASTKESLRKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVE
EMQAYSELIAVGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKFKVDGEWWTWINYEHFQELVQAYEESGGQQSFSALDYIAKTPSW
ALFGASEQGFDPADTRFQRRNKTKDITGC
>A0A832W629|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp|TrEMBL
MHSEACNVLRKQGYQFITPASSAAVKPCMWCKRALKGGEMCYKAQFYGIESHRCVQMTPT
LRCNQRCLFCWRSFEHEVVEEEECPPEVIIANLRRAQKRALAGYKVSPHVTPERFAEALN
PTMVAISLSGEPTCYSRLPELVDGLNREGYTTFLVSNGTRPEVLGRCRPYQTYVSLDAPD
RETYLRLCRPEKDYWDLVLESLAGLAGRRSAIRTTLVRGYNDFSPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLLREQMPEHAEIREFSEMVSQHSDYFIKDESPLSRVVCLERDV
>A0A2I1CC29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus novofumigatus (strain IBT 16806)|TrEMBL
MAEHSTAEGLLAFWHSYRLLFLVALSTVFVCLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KSEKGVSLESSNKATTQKAEGQLAVTNSPAKANSGPKRVTGKKPSKVAGRRGQTEDAEPL
AFIQPIVFYASLTGNTERYAKILLEELRAAAQKRADLQDRERGLLPPQIHDLSYIDLDDY
FTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEQGFCSQAKELDKWMAKLTRRKRAYPLGLGDVKSDAESSLKEWSQGLQ
DILFDILKNGGLGEGVPGSGDPVESDEELEDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSGQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHDEHISSFLVC
NAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKEK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITTEP
>A0A7J2TGT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus fulgidus|TrEMBL
MKQLSDLKGYHLIGNHSAVKTCLWLKKSLKDSGFCYKQKFYGIESHRCLQMTPALLCNQT
CVHCWRPLELLRDFKGWDEPEKIVEESIKAQRRLLSGFYGTKGVNLKKLKEAENPNQVAI
SLVGEPTLYPYLPELIECYKKRGFTTFLVTNGTVPEMVERVEPTQLYISLTAFDEKSHVE
INRPVKSFWDKILKSLEIMSNSKSRTVIRLTLIKGLNMHEKAIECFDRLIRIAEPDYVEA
KAYMFLGYSRLRLSYENMPSHEEVVEFSRKLGYELLDESEQSRVCLLRL
>G0R9T7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypocrea jecorina (strain QM6a)|TrEMBL
MRQDLVDVWHAYRTPIILSALLLLAGLRIFLHTTEDREPLVALPKIYNEPQQPQVSEKTI
SKAQPVAETEKKSSGPRRIKGGVTRKASQEDKTAPAEHDRPAKVLVFFSSVTTKTEKIAH
DYIKTLEAFLDQKANETDDKFLKPELLDLTEIDFEDYFVSPPKSPEGAAYFYLFLIPSYN
IDTINDTFLQHLQETHHDFRIDTAPLSSLVGYSVFGFGDKEGWPNEDEGFCFQAKELDKW
MSKLTGRKRAYPVGMGDMKSDHAERFTEWTFGVQEVIAQASQTGFLGEGVPGSGDAVESD
DEEAEGDDGEVVFDDEEPSNSKESDGSRPLDDVEDLGKMIRPSKDGNEGPRKAALAVDFT
TYPSASKRKGQAPVIKEMVAKDSPTYNALTKQGYSIVGSHSGVKICRWTKSALRGRGSCY
KYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFDGVKENHYK
KIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNERISSFLVCNAQ
HPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILREKRFRHRTVYR
LTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCEF
VKALDRRLQEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQRFFELLEERGPDG
DWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAVVSREAPE
>A0A8K0Y5U5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotalea sp. TS|TrEMBL
MHIGRSTNRLERSDMLDMSEVRRFANALIRQSGMYSVMDESEMSRIVVLQNQKRFTDRWI
SSYANTN
>A0A662NGJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococci archaeon|TrEMBL
MTNLFKKQHYALVGHHSSVKLCHWLKESIKNNRVCYKQKFYGIESHRCLQMTPVTAWCTH
NCIFCWRPMEGFLGVELPRPFDDPAFIVEESVKAQRKLLSGYWGVKDQINVKKLEEAMEP
KHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEPEVLEKMMKENKLPRQLYISL
TAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMHNPEGYAKLIM
KAKPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVENLPGYHIEDEYPPSRVVL
MMRDDIRKADRVIKH
>A0A3G9D2K2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp. MT-2|TrEMBL
MFISKSGKIKRLEKMGYRFVGENAHTAVKTCLWTKKSILDEGTCYKQKFYDIKSHRCLQM
SPSIFSCQQKCLFCWRDLRSTKTAWEGDYDEPASIIDDCINAQRNLLCGFFGNEKANKKK
LLEAQKPNNAAISLAGEPLLYPMINELIKEFHKRKFTTFLVTNGINHKALENLSEEPTQL
YISLDAPSKKIHNKICRPQTKNAWECLNRSLELFPSFNCRKVLRITAVNGKNMTNPSGYA
SLIKKAQPDFVEVKAYMYLGYSRQRLEIENMPLFFEVYEFADEIAKLTNMDIIDESKESR
VVLLG
>A0A2D4C3H4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pythium insidiosum|TrEMBL
MGATATAVGALLLTAGALYYVHQQQTQQQQQQQTQKATAAKSHRKKGGNKAKQNGSSKSA
ASAPPSKQEAAELPTVPVRILYGTQTGTAKALAENLEKSLFALHISGFHFQTSVVNLKDY
DQDNLEQESIVIVILSTWTNGVPPQDARVFCSWLNDMALDFRVSKTWLEKVPHAVFGLGN
AEYDEHYGTAAKNVESDLSTLGSPSLCPLGLGDDNVDQVRQFEQWRDTLIASMCEYVSEQ
HASALAAASATNGKKWLSQKEFRRQKKAQQAAQEAANGEAVELNEEDLMNEKVLTGEFSD
DEEDDTPAKKSASSADDGMVDVEDIGKSMKESEAASLSREMVTPMQRKALTKEGYKIIGT
HSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRV
WRWKTDDPEVLVTGAIERHQNMIKELKGLPGLMPHRWEEAFTVRHCALSLVGEPIMYPYI
NEFCRELHARHISSFLVTNAQFPDKIAELEPITQLYVSVDAATKESLQAVDRPLFKDFWE
RFLSCLEQLKLKGQRTVYRMTLVKEYNMAELDNYAELIAIGQPDFIEVKSVTYCGKSDGS
DLTMKNVPWHEEVRSFCAALCERVSGDYGLAAEHAHSNCVLIAKKKFCIDGRWHTWIDYE
KFHALVAKYYEDGTTFTADDYIAETPSWAVYDAPEQGFDPVETRFRRTKDGKVVEFKYEA
TDSGCG
>F8D9Z7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halopiger xanaduensis (strain DSM 18323 / JCM 14033 / SH-6)|TrEMBL
MSDSESGPKQVDSPDYHSENHTAAQTCGWTANALRGEGRCYKNVWYGIESHRCIQMTPVV
KCNERCVFCWRDHRGHAYELDDVEWDDPEAVADASIRLQKKLLSGFGGNDEVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTNPDVLRECDPTQLYVSVDA
PERHTFDQVVKAVEDDAWDRLLETMDVLREKEETRTVLRTTLVEGENMHHPDWYAGFYQQ
ADPDFIELKAYMHVGHSQGRLDRSSMPDHEDVVAFAEDVQEYMPEFDELKGVPPSRVALL
AKTEDTWVPKLKKDSDFWARDPVTSD
>A1RQN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)|TrEMBL
MSCETEALGRYHILEGPKIKIRASAARALIERHYGVAGHATVELCKWTKDALETGRSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDTFQLEERFYMEPEEIVREVLE
ERRRLLSGYWGHPQGRYRIKEALEPTHWAISLSGEPTMYPKLPQLIKLVKSLPSTKSVFL
VTNGQHPEMLRRLVEEDALPTQLYLSTNAPNRELYYLINVPVYRREDAWERWLESLDLLA
KMPTRTVLRITLIRSLNYDERYIPEFAQIVKRGNPHFVEVKSYMHLGHSTQRLKREDMLS
HQEVREWAFKLLAELEKIGARFRYMDEDEASRIVVIQNMDRYVDRWIVPPR
>A0A401HBH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aeropyrum pernix|TrEMBL
MPEKWLPLAEVMVKQKYHFAGRHTVVKKCYWTHKALTEDRHCYKCKFYGIESHRDIQMSP
AAFWCWNACLHCWRIRPQDLGVDLDETKLTIVDDPKWLVDELIRIHRRLISGYKGHPKVD
PKKFWEAWNPVHVTLSLTGEPTLYPMLSDLLKEVHRRGMTSFLVTRGVRPDILADLEEEP
SQLYVSLEAWDKKSYNYFTRPLVPRAWELTVETLEMMPSFTSPTAIRITLVAGFNDTDEA
LKGFAKLINLAQPTYVEIKSYMWVGASRMRLSKANMAEHEYVRKVSERLSDLTGYPILGE
SRASRVVLLSRLEKPIRLGKGCPEGLNTPEPEEGEYDAPYDPDIMP
>A0A0M0BHI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|miscellaneous Crenarchaeota group archaeon SMTZ-80|TrEMBL
MEEILPKAIVSALKKQKYQLVGTHSAVKKCRWLHKSLVEDKNCYKSRFYGISSHRCLQMT
PSVAWCDMRCKFCWRVQSYDLEVKWNETEPPIWESAEKIVCDSINAQRKFLSGYKSQVKD
GIISIKKFNEAMEPKHVAISLSGEPSLYPDLSELIYEFHKRGFTSFLVTNGTYPDSLERI
SNNPSQIYVSLCAPNKKVFYDICRPLISNAWEKLMTTLSLIQSFNCPTVIRLTSVKGLNM
KNVEEYSKIIREASPSYVEVKAYMYIGYSRKRMRFNNMPNHLEIRRFGESLSERTGYKLV
DESPDSRVVLLTKLDKPLPIHNKS
>A0A5J5WXU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium barbadense|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKFRRRCLKPLKHLPLNPNPRPGKLFFLSQTGTSKA
LSQRLLDLLSSKNNIPFDLVDPQTYEPEDLPEESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A3Q2WB71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haplochromis burtoni|TrEMBL
MPTFIVFVLLLASSVSASDSKVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKK
KSVSKDASKEKNDKVDKAAKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKSLG
LPAEVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSI
QADFLTWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKASPQNNSSEDD
LVESSSDEDESGLPDEKKMVLDVEDLGNIMNSVKKAKSKEESQRDGQMVKLSKLNGVQKI
EDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGV
KPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPV
TQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQ
AYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACE
HEHSNCLLIAHTKFKMDGEWWTWIDYERFQELIQAYDERGGQHTFSALDYVAKTPSWALF
GAQEQGFDPAETRFQRRNKSKDISGC
>A0A8D1W2L4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGLFAAILAEAVTSLDLPVAVVDLKAYDPDD
YLLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRL
QALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESG
SEDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKSL
SVSADVPLMGSQIFLRTSPWTPRCGCPSNPEQGSLRMRKRGAEEPLEGERSRRGAGPPTS
PLGKSSPPNPSRRNKLSRMFTRDLIVFSPQVGGGVGAGSLCAKCLGGGGRERRPPGPDDR
GGGPPGMHIPLGQRFGDLS
>A0A8H3XX92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus tubingensis|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKTIQAAAEAQG
>A0A7C7VKY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MSRRVTVQEYARRMLERQGYKMVLDHSAIKPCYWFREAMMKGRTCYKHKFYGIPTWRCLQ
MTPTASFCNLQCIYCWRLNASDVPPRFRWKEVPDPDEVWNDPEEIAEESIKLHRLLVQGY
KGVRVFNREWLYEAEIPAHAAISLTGEPTLYPFLGDLVEAYKKRGMTTFIVTNGTLPERL
ENLSTEPSQLYITVPAWEENLYKRVTRPLWPDAWQRLLKSLDLLQSFSCPTVMRITLVRG
LNTSNPEGYAKLVNRYNPTYVEPKSYTYVGYSRRRLPRDASPTHKEIREFAEELGEKTGY
RVISEAPESGIVLLSRLDEPIRLSSMR
>A0A662S935|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MRLKISLTTSLLSSGEHILHLSNQGLLSLLNQKQLISPRIGLPKRVTIQEYARRMLERQG
YKIILNHSAVKPCHWFREALMKGRTCYKHKFYGIPTWRCLQMTPTASFCNSQCIYCWRLN
ASDVPPRFRWKEVPDPDELWDDPEEIAKESIRVHRMLVQGYKGVKVFNREWLYEAEIPAH
AAISLTGEPTLYPFLGELVSAYKKRGMTTFIVTNGTLPERLENLSTEPSQLYITVPAWEE
KLYKRVARPLWPDAWQRLLKSLELLQSFSCPTVMRITLVRGLNMSNPEGYAKLVNKYNPT
YVEPKSYTYVGYSRRRLPRDASPSHSEIKEFAKRLAEETGYKILSEAPESGIVLLSRLDK
PIRLFPAR
>A0A832MIG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQSLIQALKKQKYHIIGKHSAVKRCRWFYETLINNRPCYKQKFYGIKTHQCIQMTPALFY
CTQQCLFCWRAQSGDLKIQWDETKLPEWDQPELIVEESIKAQLKILSGYKGNPKADKQKF
VEASHPRHAAISLTGEPTLYEHISDLIKVFHKKGFTTFLVSNGTLPQVLAKLEEEPTQLY
ISVCAPDEETFKKVCRPQIPDAWEKLNETLELLPSFKCPTVIRITSVKDLNMRNVEGYAK
LIERASPTYVEPKAYMHVGFSRLRLGFENMPSHKEIRDFAYKIAEETGYNVLDEAPESRV
VLLGKVQRAIRFG
>A0A497M7H0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKMQIKQGEQLVPDELLSALRRQQYHLVGRHSAVKRCRWLYEALINNRFCYKQKFYGIKS
HQCIQMSPTAFYCTMRCLFCWRVQSGDLGIKWEELKLPMSWDSPEEIVEGCIRAQLQILS
GYKGNPKTNMEKYKEALKPRHVAISLVGEPTLYEPLGELIHEFHKRGFTTFLVSNGTLPE
ALSKLSEEPTQLYISIYGPDKRTFENISRPQVPKAWEKINETLELLSSFKCPTVLRITLV
RKLNLKKPELYAKLVEKAAPTYVEPKAYMHVGFSRLRLKYENMPTHREIGEFAQKLAEET
GYKIIDESKTSRVFLLSHLEKPIKFNP
>A0A497EWF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MAIPKQIIDVYKRQGYHFVGKTSVVKPCHWLKASLLTKGEKFCYKQKFYGIPSHRCLQMS
PTLACTQQCLYCWRVQASDLNLSWDEMSLMDYDEPEEIVVKAILKQRQILSGLKSNKLVD
RKMLEEAFRPIHAAISLVGEPTLYPKIGELIGSFFSHGFKTVFLVTNGTNPKVLSNLEYE
PSQLYVSLSAPDEETYRKVCRPRIKDGWERLNETLELLKSFSCPTVIRVTLVKQLNMHSP
EKYAKLICKAEPTYVEPKAAMSLGWFRYRLPLDAMPRFEEVKEFGEQLSRYTGYKMIDFS
VNSRIILLSKLDKPIKLV
>A0A497LL77|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVPSSLIQALKRQKYHLVGRHSAVKRCRWLYETLIHDRPCYKQKFFGIKTHQCIQMTPAV
FYCTQQCLYCWRAQSGDLGIKWNELKLPKWDSPEEIVDGCIKAQLEILSGYKGNPKTNKQ
KFKEALTPRHAAISLAGEPTLYKPLGDLIRVFHKKGFTTFLVSNGTLPSALANLNEEPTQ
LYISVSAPDKKIHKELCRPQISKAWENLNKTLELLPSFKCPTVFRITSVRGVNMKNVEGY
AKLVEKANPTYIEPKAYMHVGFSTSRLGYENMPSHREIREFAEKLAEETGYKIIDESKDS
RVVLLSRLEKPIKFGSA
>A0A7C5NUH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPDTLIEALKKHKYHLVGRHSAVKRCRWLYESLVHGRPCYKQKFYGIKSHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETKLPVWDPPEEIVEGSIKAQLAILSGYKGNPKVD
PQKFREALRPRHAAISLTGEPTLYGPIGELIHTFHKRGFTTFLVSNGTVPSALAKLSHEP
TQLYVSVCAPNREIHKKVCRPILPDAWEKLNETLELLQSFSCPTVMRITAVRGLNMGNIE
EYARLIEKANPTYVEPKAYMHVGFSRLRLGYGGMPSHEEIREFALQLAKATGYKVINESE
ESRVVLLSRLEKPIKFSSD
>A0A497L3B9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLRALRLLRTEPLRVPEELRRVYRRQGYGLVGDHSAVKTCHWVRRSLNTGGEEHCYKERF
YGIPCHRCLQMTPSLGRCLQSCVFCWRATPGDLGVDWDQTRLGEAEEPDAIVEGCLQAHR
RALTGFGGNPRVPREMLEEALHPVHAAISLEGEPTLYPRLGELVEAFFDHGFRSVFIVTN
GLRPDVLASLGREPSQLYVSVCAPDQETYRRTCRPLVPDGWGRLMETLELLGSFSCPTVL
RHTLVPKLNMADPAGYARLAERAGATYLEPKAAKSVGYARRRFGYDEMAWHSDVRAFAEA
LAAESGYRIVDEHPPSAIVLLSKLEKPMRLY
>A0A7J3KJQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPDSLIEVLKKQRYHIVGRHSAVKRCKWLYEAIVHGRSCYKQKFYGIKSHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETKLPTWDSPEEIVEGCIKAQLAILSGYKGNPKAD
PQKLREALRPRHAAISLTGEPTLYEPIGELIHAFHKRGFTTFLVSNGTMPSALAKLSHEP
SQLYVSVCAPNKETYRKVCRPLIPDAWEKLNETLELLHSFKCPTVIRITAVRGLNMENVE
EYAKLIEKANPTYVEPKAFMHVGFSRLRLGYEGMPSHKEIREFALKLAEATGYKVIDESE
DSRVVLLSRLEKPLRFSHG
>A0A7C4WLP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MASQKNALESFKQTLLKQGYRVVGKHSGVKICEWTRKSLTQGRYCYKQKWYGIESHRCLQ
CSLALFWCLNRCLYCWRSFRVFLGAEMDVEPDDPKWLLDGLIKAQRELLIGYKGNIKVER
SKWEEAQNPTNIAISLIGESVLYPYLSEFIELAEKRGMKSFLVTKGTYPEGLEKLSVEPT
NLYISVCAPDEETFNRLEKPIKRNGWEAQMRSLELMKSFNCRKVIRITLVKGYNMHNIEG
YAKLIEKAEPDYIEPKAYMRVGESIRRLPEDAMPSCEEVLEFAEKLASEIGYVVKDLFKP
SRVALLSKK
>A0A8B9YFB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus grunniens|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISHPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPEAAWFCKWLEEAANDFRFGKAYLKMRYAVFGLGNS
VYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRLQA
LCKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESDTE
DHLSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALS
LVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSLKK
IDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRK
NKSKDISGC
>A0A256Z306|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon ex4484_6|TrEMBL
MDESLRRMFEKQGYAIVGNHSAVKTCHWLKESIMRGRVCYKQSFFGIMSHRCLQMTPVAN
MCNHACRYCWRYQGSDDIQVEWDDPAAIVEGTIEAQRRLVSGFKGDERCDLRVWKEAREP
NQVAISLTGEPTMYPHLGELIGEYHSRGFTTFLVTNGTFPDVLERLDPLPTQLYISIDAP
NESIYRRLCRPKISDGWERLMRTLELLPSLDTRTVARHTLVKGENLGFERQYAELDAIAD
PDFIEPKGYVFVGYSRERMSMDNMPSMDDIRSFAGRMSELTGYGIAGESPPSRVVLLKKD
GVTLRIDETPANET
>A0A8D7F234|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Musa acuminata subsp. malaccensis|TrEMBL
MAKTPLDPPLSSSRLALVALLSATSVFFLWKSRRRLRVLLSPYSSMNTPKPSPRGKIIYA
SATGTSRSLAGRLSDCLRSHGLAFDLVDPRHYEPEDLPKEALVLIVASTWEEGRPPADAQ
FLARWLAESAADFRVGSLLLAKCRFAVFGVGSKSYGDSFNAAAKDFSKWMRALGASEMAP
VWEGDVDSGDVDEVFEVWSRRIVALLKGEDLKKESGHSGSMVESVGFDESDEEVEEEVLE
PVVVDMEDIAGKAPSRRPSVALTNGWENGVKDMVTPVIRVNLEKQGYKIIGSHSGVKLCR
WTKSQLRGRGGCYKHSFYGIESHSRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDN
PLEIVDVAIDEHTKMIKQMKGVPGVKPERLSEGLSPRHCALSLVGEPIMYPEINTLVDEL
HRRHISTFLVTNAQFPDRIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLK
ALQDKEQRTVYRLTLVKGWNAEDVEAYANLLGIGKPDLVEIKGVTYCGTSATSKLTMDNV
PWHSDVKAFSEALAMKSSGEYEVACEHAHSCCVLLAKVDKFKIKGEWYTWIDYERFHELV
ASGKSFKTEDYMARTPSWAVYGAEEGGFDPDQSRYRKERRHGAASVQT
>A0A371NCX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter defluvii|TrEMBL
MAMYLEESQRRMERMGYRFVGEHRHSAVKTCLWTKKSIVNEGVCYKEKFYGIRSHRCLQM
SPSVPFCQQKCLFCWRDLSSTGTAWEGPHDEPADIIDGAIEAQRKLLCGYLGNERADKIK
VMESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLAEEPTQL
YISLDAPDRDTYKELCRPQISGAWDLLNSSLELMPSFSCRKVLRITAVRHINMKDPEGFA
RMIERARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDESRESR
VVLLA
>A0A151AC72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halalkalicoccus paucihalophilus|TrEMBL
MSGPKQVSSPEYHSENHTAAQTCGWTANALRGEGKCYKYAFYGIESHRCIQMTPVVKCNE
RCVFCWRDHRGHAYELGDVEWDDPEAVVDASIRLQKKLLSGFGGNDEVPREVFEQAMEPR
HVAISLDGEPTLYPYLPELIDAFSDRGITTFLVSNGTDPEMLARCEPTQLYVSVDAAERA
TFDQVVRPVDDDAWERLIDTMDVLAEKDETRTVLRTTLVGGENMHDPDWYAAFYDRADPD
FVELKAYMHVGHSQGRLDRSAMPDHEDVVAFAEGVREHLSEHEYLNDVPISRVALLSKTE
ETWVPKLKKGSDFWDEDPLTAD
>A0A1S3YAM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nicotiana tabacum|TrEMBL
MSPSLSSYPTRLAILTLLSATTVYFFYKSRRHLFKRLISLNPNPKTPKGKLFFISQTGTS
KTLAKNLHSLLNLNGFDFDLVDPKDYEPEDLHKESFVLIIASTWENGKPPSNAGFFIDWL
NESVDDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVARDFSKKLRQLGGVEVLEVGEGDV
DEGNLDEVFGKWSKRVVGVWSNLGQNGGYMVNGVGDGNEDEVVSEGDDDDDDDDDDDEFE
ENDEGSEILDLEDIAGKGPSRKKGVGDKLVNGKLNGDIVNGEKEMVTPVIRASLVKQGYK
IIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGKSWRWKMDDPIEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIM
YPEINSLVDELHKRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPLFG
DFWERFLDSLKALKEKEQRTVYRLTLVKGWNAEEVDAYFNLFSIGKPDFIEIKGVTYCGS
SATSKLTMENVPWHSDVKEFSEALAKKSNGGYEVACEHVHSCCVLLAKVDKFKIDGQWYT
WIDYEKFHDLVASGKPFTSKDYMAPTPSWAVYGAEEGGFDPEQLRYKKERHHKSSRKENG
S
>A0A2E4WVT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIASRLSKQRYHLVGEHGGVKVCHWTKQSLVADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLHKIDDDPYELYLESVRAHRRLLTGYGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHQHGTSTFLVTNGSLPKVIEELDPLPTQLYVSVDAP
NKEIFDRICKPKFDQNAFHKLEQTLELLPSLDTRTVCRHTLIKHESLGHHEDYARLDNIA
DPDFIEAKGYVFVGNSRNNLSIDNMPTHAEVMEFSETLAPMVDREVLSDRRESRVALIGR
EMVPVTLPEKTRGLPSDLGIAKPQRFVLPQA
>A0A534KT54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGIGCYKQTFYGIESHRCLQMTPAVD
ACNLACQFCWRTQEWGSNSLLAADDPAFIVDESIRAQRELLTGYKGNPNVTRERFLEAWH
PTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQLYVT
VAAPTAEIYRRLVAAKSDNEWRKLKETLALLPTLPTRTVVRHTLVEGWNLGWEDEYAELD
RLGKPMFIECKGYSFVGESRLRLQAENVPSHASIRTFAERLADRVGYQIAAEREDSRVVL
LTQDGALHPISP
>A0A2E4QJ16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLTGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTHLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSAHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVTREVLSESRPSRVALI
GREIVPIPIPEAELFFPEDLGIAPPVKKLPLVQN
>A0A7K4ANK8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MATDVKRTLEKQQYKIYGDHAAVKLCHWMKQSLLHGRVCYKEEFYGIRSHRCLQMTPVVN
QCTHNCLFCWRVQGFESEEVQWKEPEEILDRCIQEQRKLVSGFGGDERCSREMWQESREP
RHVAISLSGEPTMYPYLGDFIDVCHRRGMSTFLVTNGTFPEVLEKLDPLPTQLYVTVAAP
TEEIYKRLCVPRIPDGWERLNRTLELLPSLDTRTVIRHTLVKDWNIGWEGDYAKLDAKAD
PTFVEPKGYVFVGDSRRRMTIDNMPSPAMVREFSERLGRKLGMQVLMERRDSRVALLGRQ
GSKTSLF
>A0A7N5P7Y2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ailuropoda melanoleuca|TrEMBL
MDFVQLFIFKDKNSREKSVPKATQDLMTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFAA
SLAEAAASLDLPVAVINLKEYDPDDHLLEEVTSKNICAFVVATYTDGRPTESAEWFCQWL
EEASSDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDC
DVAKSKHGSIEADFRAWKTKFLARLQTLQKGEKKPCDGNCKRGQCESSTEEEPFESTSEE
ESGTEDHQNPNSVVDVEDLGKIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITP
ALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVK
HCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTK
DSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPD
FIEVKGVTYCGESSASSLTMANVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHK
RFKIDSEWWTWIDYNRFQELMQEYEDSGGSATFSAKDYMAKTPHWALFGASERGFDPKDT
RYQRKNKSKDISGC
>A0A2E5YWH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDQRLKATLQKQRYHLVGEHGGVKVCHWTKESLLRDRMCYKGKFYGVKSHNCLQMSPVVD
QCNLACTYCWREPHMDTLGLKDQDPLDMLYESVRAQRRLLSGFGGNDKVNKEKFLDAQNP
KHVAISLNGEPTLYRRLGEYIDECHKHGMTTMLVTNGTLPKVLERLDPLPTQLYVSIDAP
NKEVFDRICRPKWNNGVWEKLEKTIDLLPSLDTRVVARHTLIKGENMFGYENQYAKLDER
ANPDWIEAKGYVHVGNSQNNLDITNMPYHDEILQFSNTLAELTGLQVLDDSKPSRVALIG
KEKIPLPIPQIVKEFPKDLGIAPPVKHLPLA
>A0A7N5JVR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ailuropoda melanoleuca|TrEMBL
MDFVQLFIFKDKNSREKSVPKATQDLMTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFAA
SLAEAAASLDLPVAVINLKEYDPDDHLLEEVTSKNICAFVVATYTDGRPTESAEWFCQWL
EEASSDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDC
DVAKSKHGSIEADFRAWKTKFLARLQTLQKGEKKPCDGNCKRGQCESSTEEEPFESTSEE
ESGTEDHQNPNSVVDVEDLGKIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITP
ALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVK
HCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTK
DSLKKIDRPLFKDFWQRFLDSLKALAAKGVTYCGESSASSLTMANVPWHEEVIHFVRDLV
DLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQELMQEYEDSGGSATFSAKD
YMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A093SIS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Manacus vitellinus|TrEMBL
LDVSMDTWSYFRTCLASIWLHRFYIYSALALGISLWIVTQFTTTKTKKKGEKSSGNPTSS
KGTEDKLVNGCATPQAEEVYVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGD
YDPDDCLAEETTSRSICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKTHLKGLRYA
VFGLGNSVYVDHYNTVGRRMDRWLWMLGASRVMTRAEGDCNVAQSRHGSIEGDFQAWKAK
FLTRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHERGASEHENTEAEELFETSSEE
EADAEEAGGTNSIIDVEDLGNIMGHMKKAKEGDVGRRENPGRKEEEEEEKREMITPALRD
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPELILQEAIENHQNMIRQFRGVSGVKAARFEEALTVKHCAL
SLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTRESLR
RIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVGFVQDLAELLPDYEIACEHEHSNCLLLAHTKVSS
PG
>A0A7K3Y8I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MHSEACKALRRQGYQFVNTTSSAAVKPCMWNKRALRGGDMCYKAQFYGIESHRCIQMTPT
LRCNQQCLFCWRSFEHEVKEEEECPPAEIIGSLRRLQKKALSGYKVSPYVTPERFAEALD
PTMVAVSLSGEPTCYSHLPELIDGLNSDGYTTFLVSNGTRPDVLARCRPYQVYISLDAPD
RKTYLGLCRPREDYWDRIQESLAGLATRRSAIRTTVVRGYNDFAPERYAAIYQDSGARFV
EVKGYMYLGYSRKRLKREQMPEHGEIRAFAEEIAEHCDYSIKDESPVSRVVCLERDI
>A0A8H7GQU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metschnikowia persimmonesis|TrEMBL
MPEKPSPILEVDFTHAYMPHEKTVFPKAVPLSAKPKKKNSAEPSLTANTFKLTESPIYIF
YTTLTGSSHRVAKTLHEKLSNIDELSVPPKLLSLDDDVDDLEEFFMKTPKSSKPNIYLLV
LPSYETDSPIDYFLEHLQETTQDFRVDKYPLRPLAGFAVLGLGDSESWGGAKFCYQARLA
DRWMGKLGARRLFPLGQVCMKHEGEPKAYDWINRFAELLADDEPFHVDENDAVDDSDAEE
EEIDPASDVVDVEDMGAIIRASNGSLTAMEPKQMVAQDSPTFKSLTKQGYTVVGSHSGVK
ICRWTKSAMRGRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWE
VDPPEKVLHGALEGHYKKIKQMRGVPGIQMDRFEEAFQVRHCALSLVGEPIFYPHINEFV
GMLHEREISSFLVCNAQHPANLEALAKVTQLYVSIDAPTKQDLKKVDRPLNSDFWERLIA
CLDILRTTQAHQRTVFRLTLVKGFNMGDIKSYADMVERAQPSQIEVKGATFCGSSAGNGN
PLTMQNIPFYDECKDFVTSLVSELNSRGQTYELAAEHAHSCCILIAHTKFHINGVWHTHI
DYPKFFELLKSGQDFNALDYVKETPAWALWGSDEAGFNPIDTRYDRKAEKLKKKEARDAQ
AAHVQAIASGM
>A0A7K4MQ49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSGEVIEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEDIITKLMAERKKLIM
GHYGDPNQDKKKLDESLLPSHYAISLSGEPTMYPKLPELIKHLKSLEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYESFLKINRPRYDDSWERWNKTLKMLSTLDTRTVL
RLTLIRGYNDNEKMIPAFASLLQKSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRSFA
NKLVQENNDFTVMDESGISRIVILQNKKRFVDRFIPACC
>A0A7K4NB25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSGEVVEKEPELIQIRPSIVNQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHSCMEFSPAGMYCENRCIYCWRPMEFYDSMEMKPQNVAEPEDIMTKLMAERKKLIM
GHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPALIKYLKSLEATKSIFLVTNGQE
PDMIQKLQDENALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDTRTVL
RITLIRGYNDDKEMIPAFTSLLQQSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRCFA
NKLTQENNTFTVMDESEISRIVILQNKKRFVDRFIPAYS
>A4HSJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania infantum|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTASPAAAEDVICPLVRVMEMREEEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGV
APPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGL
GAPPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAAS
ATEARSCKGGSATVATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCA
CRKADTIADGVAVSKSDDDDDDSNAENDGMDDVEDLVWDGTDDADFDLSKDPSELPELLY
PKLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACA
NKCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLAMAMQI
RHCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRNLKPVVQLYLSIDAPT
PEELKRIDRPLFEDYWDRCLSCVKELARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQP
DFIEVKGVTYCGTSSNSTLNMKDNVPRHDEVVGFCKALCAEMASRHPHYRTPQMDKEEEG
GGDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRTD
FTSLDYAAVTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTASC
>A0A6J2MFJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MGPSLDSWDFSPLISLWINRFYIYLGFAFAISLWICFQIAIRKQLFIFKDKNSQKKSVPK
ATRDLMTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPVAIINLKDY
DPDDNLVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEAASDFRFGKTYLKGMKYAV
FGLGNSVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEADFRAWKTKF
VFQLQVLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEEEEPCESSSG
EESGTEDHQSLTSVVDVEDLGKIMSHVKKEKREKEQQEEKTGLFRNTVKKEAGERRAMIT
PALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGVKEERFKEGMTV
KHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLTPVTQLYVSVDAST
RDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSP
DFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLIAH
KKFKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPWALFGANERGFDPKD
RRYQRKNKSKDISGC
>A0A8J2I4C5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria atra|TrEMBL
MALLELLEQLSAGLLRIWHEHRLPILLAALVVATIARLAIYSRDRREKLSVSPAPSSPAP
VEKTTSVQLKPEWLPEYTTTLNSSELNVDNHAEDDTRAVAAVAKVKKGPKMVKGRKTPKK
LAAAPTFDHQADRIQPLVFFQSLSGTTERYAKQFVEVLSEWTKGCDQSKSFLEPQTLDIS
YIEHDDYFISPPKSDVNVKYFYIILVPTYNIDTVLDVFVESLQETHNDFRIDTAPLSGLV
GYAVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMADVKSEAEERLQDWR
IGVQDALVEIVEGRGLGEGVPGSGDAIESDEEDLADEDGQSTRVDDVEDLGSMVNSSAGP
IPVDFTTYKKSATKPESLQAATPRQVPKEMVPTTSPTYAALTKQGYSIIGSHSGVKICRW
TKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPD
LIFDGITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLDIMHR
NRISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDIL
RNRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTM
QNVPFYEEVAEFVTELEKELNSRGLTYGIGAEHAHSCCVLLADRTRFRKNDKWATRIDFE
RFFDLYEGKVQGTRMEGEKVVGWRPEDYVGEETPEWALWGNGGFDPRDARVYRKGKGPRG
DEDGEKGAVAGKATATALEF
>A0A2T9WX56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobales archaeon SCGC AB-777_J03|TrEMBL
MALRVETFSSINRALEKEGYRIIGSHSAYKKCHWTHEALVNNRYCYKGKFYGIESHRCVQ
MTPTSSWCWFRCIHCWRLEPEDVGIEWDETKLPEYDDPEMIAEKSIEEHRRAVSGYLGRN
DVDLNKVKEAMEPKHVAISLTGEPTLYERLGELIAEYHRRGLTTFLVTSGVRPDVLASLE
EEPTQLFVSIQAPNERKHKMINRPIIANSWSLVMKTLEILPSFSSPTVIRMTMIKGFNMS
ENDAKEFAELIEIAQPTYVEVKAYMHVGPSIMRLTRDAMPTHNEVKRFARVLAEYTGYKL
LSEHVPSRIVLLSRLDKPIQIGAAWTERWNWSTPDTEDDSSGEYKGL
>A0A7K5U629|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cephalopterus ornatus|TrEMBL
LDVSMDTWSYFRTCLASIWLHRFYIYSAVALGISLWIVIQFTTSKTKKKVTEPVRTEDKL
VNGCATPQAKEVYVAAVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPDDCL
AEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRVGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRRVDRWLWMLGASRVMTRTEGDCNTVQSRHGSIEGDFEAWKAKFLTRLQA
LCRGEKKPCSGKCKKGKCRSPGKQNKESSDHEHGASEHENTEVEELFETSSEEEADAEEA
AGTNSVVDVEDLGNIMGHMKKAKSEHELQDGGVGRRENPGRKEEEEKREMITPALRDALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFRGVSGVKAARFEEALAVKHCALSLV
GEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIR
>A0A1V6TMD1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium steckii|TrEMBL
MAGTPAMIDSLAVWHAYRLPLLIALAVLVLTLRVYRQFNSRSKTAASSSVPVSPRSQSPE
KSEKPDAPAQKSISPSTASPTTKITEKPTATPAAAVKSTAGPKRVQGRKPVKTIGGRRSS
AENKENGPRVSFIQPIVFFASLTTTTERYANLLLEDLRIAVEKQSTSEDRKKGILPPQIH
DISYLEFDDFFTSVPEAPADSPDIPGTRYVYCILVPTYNIDTVLNTFLGHLDETHNDFRI
DTAPLSKLGGYSVFGFGDKEEWPTEEEGFCSQAKEIDRWMAKLTGRKRVFPLGMGDVKND
PEGALKDWTNGLLDIFNDIVEYGGLGEGVSGSGDAVESDEEDIEDDEESQKKKSSTMVDL
EDIKMNGEGDSSAAPIPVDFTTVGKAGTTTDTAKEMVPKTSPTYAALTKQGYSIVGSHSG
VKICRWTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRW
KVDEPELIFNGVKEGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRF
LEMLHNERISSFLVCNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQ
RCLDILREKRSYQRTVFRLTLVNGFNVDDEVQGYANLVEKALPGLVEIKGVTFCGTSTSA
GAGLTMKNVPFYEEVAAFCVALNAELERRGLKYGIAAEHAHSCCVLIASERFRVNDKWHT
TINYQRFFELLEKEKADGTPFTPEDYMAETEEWAYFGNGGFNPDDERWYRKNRKPRPIDV
APESAPSS
>A0A067HA68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Citrus sinensis|TrEMBL
QHISNLGPRKLVSLQDPENLTFGKTVESRNCSRLQEATTFYFAYKSRRLNKFLRHSDYRK
KPENPNPNKGKLFFISQTGTSKTLAKRLHALLTSNDLLFDLVDPQTYEPEDLSKEALVLI
VASSWEDGKPPEAAKFFMNWIDESANDFRVGSLLLSNCKFAVFGVGSKSYEKTFNMVAKD
LSKKMRELGAGEVLPVVEGDVDGGELDVVFEDWSKRVVAILKSGGDRLENGIVNGEASIV
GVESDPVYHEYDDDEEEEDVVESEMVDLEDIAGKGPSRRSVNVAETNGKVKDSKRDMVTP
VIRASLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGKSWQWKMDDPIEIVNTAIDLHAKMIKQMKGVPGEYSIFVLLDFFYF
GTVSSAIDKQIPSNDGEEKEGGVTLERLNEGLTPRHCALSLVGEPIMYPEINTLVDELHR
RRISTFLVTNAQFPDKIKLLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFL
>A0A6A5XAD0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aaosphaeria arxii CBS 175.79|TrEMBL
MSAPELLEQLPEELIFLWHQHRIAILLSALTILVLVRLTVHLRTKREKVSASPVPGSPTE
KKVVEIKPEWLPENTTLDVSALTVDDHAEDSVAAVAPLVKARKGPKTVKGRKTPSKKPVP
EAVFNHATDKIQPLIFFQSLSGTTERHASSFEKIFSTWISGQDSAATILPPQVHDISYIE
YDDYFITPPKSADNTKYFYIILMPTYNIDTVLDIFLESLRETHNDFRIDTAPLSGLLGYS
VFGFGDKEGWPTEEEGFCSQAKEVDKWMARLTGRKRAYPLGMGDVKDDVDMRLEEWRLGV
QEALGDIAQGKGLGEGVPGSGDAAESDEEEDIDVAEDSDVEVETQKLKPKSKKSSRIDDV
EDLGSMVNSSNNNNTSSPSSSETPLAIDFTTYKSKSKPAPAPTPKEMVPTTSPTYAALTK
QGYSIIGSHSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRH
GTNPVGTTWRWITDAPDTIFDGITTAHYKKIRMMKGVPGVRAERFAEAMRIRHCALSLVG
EPIFYPHINDLLTIMHSHRISTFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDR
PLHRDFWERFCACLDILRNRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPSFVEVK
GVTYCGTSAAGSAGLTMQNVPFYDEVADFVRELDAELARRGLAYGIAAEHAHSCCVLLAD
RTRFMRDGRWHTRIGYDKFFDLCEGKTQGTRVEKDEVTGEEKVVGWRPEDYIGDETPEWA
LWGNGGFDPRDVRVWRKGKGPKKDETAPATDADADAHTPRAIVEI
>F2Q595|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97)|TrEMBL
MAAMPLQIALSLWHAYRAYILVIIAVALFAGTKFSSQRKQAESQTKGAEQVTQNITVSDN
PVQPGNTSLAKSTPLKSETKPGPKRLRGLRPLKGDANATAKVVSAIRPIFFFTSLTGTTE
KSARVAFESVKSKLQAAPENTQCKVLDPELHDLSYIDFDDYFVTAPKPPTSEPGLSYLYC
IILPSYDIDSIINNFLNHLDETHNDFRIDTSPLSGLTGYSVFGFGDKEGWPTVEEGFCSQ
AVAVDKWLAKLTGKRRAYPLGFGDVKTDGDHSLQEWCDGLVSVLHDIAENGGGLGEGVPG
SGDPIESDEEDAEEDSQRPQNPSRPRRTKARNSQIADLEDIKFNPEDLLDDEPIDFTTYA
PTKISSLSSKEMVPSTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYG
IKSHLCMESTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLR
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLSLLHNEHISSFLVCNAQHPDELA
ALQRVTQLYVSIDASNRESLRKIDRPLHRDFWERLQRCLDILREKRNVHRTVYRLTLVKG
FNIEDEVEGYADLVEKGLPCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNE
ELERRGLSYGLSAEHAHSCCVLLASKRFLVNGKWHTRINYERFFELLEREKQTGESFAPE
DYMRETEEWALWGNGGFDPNDQRVHTKGKNKGKIGVPPPSGKVILAGTA
>A0A179UB96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blastomyces gilchristii (strain SLH14081)|TrEMBL
MAWEDLGIVARGLLTLWHRYRAPIFLLAAVIFTVVWLAPRNSQPNTPEPDSLPASLNKNQ
NQNAKSELESFSSNDQAAGDLPKRHRSRSSSVDNRPKQVTQPANGPKRVRGIKPEKNGAK
HQIGGGGLPRGIVIQPLVFYASLTGATETYAKSFCDRLQKASHPLLENNGKTNILPPELH
DLSYIELDDYFITAPKPPESAPNTRFLYCILIPTYNIDTMINTFLGHLDDTHNDFRIDTS
ALSGLVGYSVFGFGDREGWPTEEEGFCSQAKAVDRWMAKLTGKKRTYPLGMVDVKGDNIQ
KVLNEWCDGLTDVMFDVMTSGGLGEGVRGSGDPVESDEEDIDDDGEDINENGENRRNKGK
NEQIMDLEDINFGGSNSRNAFANAQPLPVDFTTQSRAQASKPASQLEMVPTSSPTYAALT
KQGYTIVGSHSATNVYSVGATEQTPLELPGAGKWILLISFLMELRLNTIRKLKCFVVCLV
FRAERFAEAMSIRHCALSLVGEPIFYPHINKFLSLLHNDRISSFLVCNAQHPDELAALHR
VTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVD
EEAAGYADLVEKGLPCFVEVKGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELTR
RGLGYGIAAEHKHSCCALLASNRFYVNDRWHTRIDYDKFFTLLEKEKNEGIPFRPEDYMR
ETEEWALWGNGGFDPKDTRVHTRGRNKAKLNAALKEAQDASVSAEG
>Q8U081|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)|TrEMBL
MDIKPGKITVQANPNMPEEIANLFRKQHYELVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTEVPEPWDDPAFIVEESIKAQRKLLVG
YKGNPKVDKKKFEEAWEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPES
LREMIKDDKLPTQLYVSLTAPDIESYNKVNIPMIPDGWEKILEFLELMRDIPTRTVVRLT
LVKGENMHNPEGYARLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIREFAEALVK
YLPGYHIEDEYEPSRVVLIMRDDVDPSGTGLEGRFIKH
>A0A7J4EPG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobaceae archaeon|TrEMBL
MPEKLLQDLKGYQIVGNHSAVKTCLWLKKSMKDEGVCYKQKFYGIASHRCLQMTPALICN
MNCIHCWRPLKLLPKVRGWDDPEFIAKESIKAQHKLLSGFHGTANVNRRKLEEAYSPNQV
AISLIGEPTIYLYLDELVRKYRSKGMTTFVVTNGSNPDMVEKIEPYQLYISLTAYSEDSH
ISLNRPVKSFWDKINRSLEIMAEKDTRTVLRITLIKRVNMEPEKFAPLIEKASPTFVEAK
AYMHLGYSRYRLDRSAMPEHEDVKNFAEKISNITGYEIKDESEISRAVVLRC
>A0A832S9Q4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina acetivorans|TrEMBL
MPLEERKEEKENSGENFPEIPEENRGEEQSSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLKTYLRVCQPKSPALWDRINESLDIMK
DKCSRTVIRTTLVKGENIFNPKGYAELIKRASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGKKSPVKKISCQD
>A0A6J3GRS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapajus apella|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGFVSLHNKDIFVSGVKIFYGSQTGTAKGFATVLAETVVSLDLPVAIINLKEYDPDD
CLIEEVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSVYASHFNKVGKNVDKWLWMLGARRVVSRGEGDCDVVKSKHGSIEADFRAWKTMFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSEEQDELHHRDTEEEEPCEGSSEEEF
GGEDQQSINSIVDVEDLGKIMDHMKKQKREKEQQEEKTSLFGNTGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVKHC
ALSLVGEPIMYPEINSFLKLLHQRQISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
LGTSNKGSFKRFLLRQTVKKKR
>A0A842LYA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylicales archaeon|TrEMBL
MVEGPFRTLRAQGYQIVGRHSAVKTCHWVRKALTEGKICYKGRFYGIETHRCLQMSPAVV
YCTNRCVYCWRPLPGERGFEWASGRIPVEDEPKEIVDGAIEAHRRALSGYKGNPKVPADR
YKEAIRPRHVAISLSGEPTLYSRLSELIEEFQRRDMTTFLVTNGTNPKALEGLREPTQLY
VSVSAPSEGVYRRVCRPSAEGNWESLMGTVSMLRTFKCPTVVRITLVKGLNMEDPDGYAR
ILSMGNPTYVEVKAYMHVGSSIWRLGAEAMPSHEEVVRFAGEVANRSGYDLVDDVPASRV
ALLSRVSKRVQF
>A0A8H6AS86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis fragariae|TrEMBL
MAYDSWISRPIWSYDIDDIVALWHLYRIPIILTTATILILVRVTLRPRALREKLSASPLP
ASPVLPAVKEKISPPVFDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTANSFVESIRGDLSGRADGQRIQFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVLDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTTGEEPEELEIDFTTVGLKKGKAKTTPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGEDKVAEDNTKDDLAF
>A0A671FDC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinolophus ferrumequinum|TrEMBL
MAPSLDTWDFSPLISLWINRFYIYLAFAFGITLWICFQIVIRKQSFIFKDQNSQDKSVPK
ATRDLMTNGSVSLEKKEVFVSGVKIFYGSQTGTAKGFAAALAEAISSLDLPVAVIDLKEY
DPDDHLLEEVTSKNVCAFLVATYTDGRPTENAEWFCKWLEEASNDFRFGKSYLKGMRYAV
FGLGNSAYASHFNKVGKNVDKWLWMLGAQRVMTRGEGDCHVVRSKHGSIEDDFRAWKAKF
ILQLQVLRKGEKKPCDGNCKKGKCESRQPGSEEVEPGSPARDRLQQRDHAEGPFESASVD
ESDPEEQPSVPSVVDVEDLGTIVSRVRKEKRAKVQQEEKAGLFGNEVTNEASERRAMITP
ALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVREQRFTEGMTVK
HCALSLVGEPIMYPEINRFLKLLHESKISSFLVTNAQFPVEIRKLMPVTQLYVSVDASTE
GSLKKIDRPLFKDFWQRFRDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVCLGSPD
FIEVKGVTYCGESSASSLTMANVPWYEEVVRFVHELVGLIPDYEIACEHEHSNCLLIAHK
KFKVDREWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMAKTPHWALFGASERGFDPKDI
RYQRKNKSKDISGC
>A0A0C9LM52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fungal sp. (strain No.11243)|TrEMBL
MTSTSATQLFTELVSLWHHYRIELLVLGGLVLLALRLASLRRQAAPDLSPKAGDHAHIRT
VKVPQDAARLISTTRPIELAPSAVSRTKSDGPKRIIGTRKAQALNGGTLTPEAKIDLVVF
YFSLGGSTAKIASELVSSLDLQEHSLLRKPQLHDLAEIDFDDFFVSPQKTPGDSRQYYAF
ILPTYNIDTELNTFIDGLAETHNDFRIDTAPLRALAGYSVFGFGDQEGWPTEEQGFCSQA
TEVDRWMARLTGKKRAFPVGMADTKMNPVAPLKEWLEGVLEGVSGIAKGNGLGEGVEGSG
DAVESDYDDEEIVVEDDLASTKADKLKSRKRATPAADLEDIQGPTEGADEVDFTTTSPKR
SAPKEMVPENSPTYTALTKQGYTIVGSHSGVKLCRWTKSALRGRGSCYKFSFYGIKSHQC
METTPSLSCSNKCVFCWRHGTNPVSTTWRWTVDAPDLIFEGVKAGHYRKIKAMRGVPGVR
AERFAEGMRIRHCALSLVGEPIFYPHINELLGMLHKEHISTFLVCNAQHPDQLAALQHVT
QLYVSIDASNKEALKRIDRPLHRDYWERFLRCMDILRAKRDVQRTVFRLTLVKGFNIDEE
AEGYADLVERARPGFVEVKGVTYCGTSTSAAAGLTMQNVPFYEEVCAFVEALNRALDRRG
LGYGIAAEHAHSCCILLAEKERFYHEDGWHTLIDYEKFFQCLESGEEFGPQDYVGGQTPE
WALWGRGGFDPRDDRVDRKGRKKEGTVTVGGGKVVEF
>A0A210QQT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mizuhopecten yessoensis|TrEMBL
MLEKILTATVSEYIQLPVWTVALATGCLVWLLHIGRKGVNPKKGYSSPPETVTNKAEPTI
STSDTTQARQKKLKVLFGTQTGKSKTFAGLLASDAERKGFTSEIQDLKVYEPEDTLADEA
DDCYLVVIISTYTEGQPPEGSAWFLKWLQDTSSDFRVQKTLLKDLNYAVFGLGNSLYKEH
FGVVGKKVDSLLHQLSGHRIVNAGVGDENVAESKHAGIEADFDAWRAEFWRKMKTLKNLP
FTKKVDQQKKNDKCSDGSNNCGGKCKCKDSEEACSSGEELYETTSEEEDDDDEEEEANED
GSDMSLQKSNGVVDVEDLGKVMKNMKKAKVRRKREDLAKASAEPKEMVTPALRKALEKQG
YRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDDAETVIEGAIQNHRSLIKQFKGVPGVLPTRLQEGHDIQHCALSLVGEP
IMYPEINKFVDLLHDKGISSFLVTNAQFPDAIKNMSPVTQLYVSVDASTKESLKKIDRPL
FRDFWDRFMESLLALGEKRQRTVYRLTLVKAWNTEEIENYAKLVSKGKPDFIEVKGVTYC
GESKASTLTMENVPWHEEVIKFVKILEDELDEYEIASEHEHSNCLLMAHKKFKVNGEWWT
WIDYEKFHKLVQAFKSSNGQETFCAEDYMAKTPSWAVFGCKEQGFDPKETRFRRKKRKDI
GGC
>A0A662TSM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MQTLAYPSEIAGILRKQKYQLVGRHSAVKKCHWLHEMLVNQRPCYKQQFYGIRTHRCLQM
SPAVVFCTQRCLHCWRVQPPDIGLEWSELGPDEWDPPELVVEEAIKAQRRILTGYKKHPK
VPEALWREAWNPNQAAISLSGEPTLYPYIGGLIREFHRRGFTTFLVTNGTLPERLEALPE
PPTQLYISLTAPTEEAHRVLCRPLLKDAWKRILRTIDLARERFDRVVYRITLIRGWNDRY
ADEYAKLIERGQPPFVEIKAYMFVGYSQRRLTLDAMPLHRHVMEFAEELAKKTGYQLYDE
NISSRVALLVSGAVKPRIPGL
>A0A5D2DPL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium darwinii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPQHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSAGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A7L4RMY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MPEALAKQMRKQQYHIVGGHSAVKSCKYLKEGILGKRTCYKNTFYGIDSWRCLQCSTMLS
CNLSCRFCWRISPEDIGLSWNEMSTPDWDAPELLAEGFLREQKRIVSGYKGNPKVERKRW
EEANKPAHVAISLVGEVTIYPFLSELIEVFHRKGMSTFVVTNGTLPERLSNLKTLPTQLY
MSLVAPDEETYTKTCRPKVKGAWEKVNRTVELFPSFKTRKVLRLTLVRGLNMLKPEEYAE
LILKAEPDYVEPKSFVFVGGARYNRGLELGDMPSHEEIRVFAKKLSEETGYIISDERTDS
RVVLLCKDKDAEKRRFIQKK
>A0A662GBS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MNSARFTEKQIQRYLRAGYRLVGKNTAVEICRWTRSALKEGRLCYKRWYGVNSHRCIQMT
PNLNFCNFACSFCWRIHEEGRFKLTPEWDEPIEIVDGIIRVQRELLIGYKGNPRVPKERF
LEAMFPRHVAISLDGEPTMYPYLSKLITEIKERGMTAFLVTNGSIPARLKELLMENAEPT
NLYISVYGPNEEIFQKTSKPLIPNAWEKVLESLDLMDEFNCRTVFRITLVKGLNMVDPEG
YAKLILYANPKFVELKGYTWVGESQKRLPKEAMPRMNEILEFAAEISRFTGYKVKVMDEK
SRVVMLVKDENIWNWNLKLVKEQREIEAKIDSLWRNKIRDFRLKKMRLDF
>A0A833EEP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus okinawensis|TrEMBL
MATYNTLIPEEIYRILRKQRYQIKDHSAVKLCGWVKKSLLENKNCYKSKFYGIETHRCIQ
CTPSVIWCQQSCIFCWRVLPSDIGISQLSHPKVKWKEPEEVLEDILQMHRKVVMGYKGIL
DRIGKKRFKELLDPKHVAISLSGEPTLYPYLDELINLFHRRGLSTFVVSNGILTDVIQEI
NPTQLYISLDAYDLDSYKRICRGKEEYWQSILDTLDVLRSKERTCIRTTLIRDYNTDIEK
FIPLYERADVHFIELKSYMNVGYSRRRLTLDHMLKHEEILELSRKVEELSHYKVADDSYD
SRVVLLVNEDRKVKRFIR
>A0A662HNR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVRRKRRLKIDFEEAKKDPYRVLFAILRKQKYHIVGHHSAVKKCHWTHAALTEGRFCYKC
KFYGIETHRCVQMSPAVLWCWNACIHCWRLRPQDIGIEWDETRLPTVDNPELIAEGVLRE
QLRILSGYKGNPKVNRKLLEEALKPKHVAISLTGEPLLYPRLSELIQIFHRKGLTTFLVT
RAIRPDVLADLDEEPSQLYVSFEAWNKEMYNKLNVPLAPRLWELSLKTLEILPSFTCPTV
MRITVMKGINMGGKDAEGFAKLVELAQPTYVEVKAYMHVGASTKRLPRSAMPRHGEVRAF
AKLISEKTGYPIVSESIPSRVVLLSKLKKPIRLGKGCPEGWKTPDIGGEESGEYGKYISE
V
>A0A197K5D6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Linnemannia elongata AG-77|TrEMBL
MTAASSNLQLWKEYRIPLVCMAIGIATLSIILSNKNKDNTNNNDSTGANSKSQDPSGKKA
SNKVEKIVQDMEQDPTIPELSEEAVTRVVDHATEEQKPYQHRGLKKEEFRKLPKVIRKKP
KKKQAELNAVAAASTLATATATSETSGCCGGKNKPAGDTSTGCCGGKHKPAAEDSVAAVN
GCSSGNGCACSSSSAPTAPVLTKVDPLLLPYLVEPIKVFYSTITGTAKLFAQQLVDSAVS
HGLPEPKLIDIVDYDTEDFLSESSLSIFILSTYNVEGPNDWFLKWLEDTRFDWRVEKGAL
SKLKFSVFGLGDSAYTEEFCNGPRSADKWLGQMGAQRVWPFGEGDKNGDQGGAFKQWNDA
LLASLLDPHQSHVHEAYFSSDEEDGASASENDDDEDLDEDGEPVKKTKEEKLGLPTIDGG
DASEGEMVDLEDMGNIARKIKQAKEDKALDEEAFANEKVRAKRSVGETKDGKAIKPREVR
EMVSPLLYKSLTKQGYKIIGSHSGVKICRWTKAALRGRGFCYKHSFYGIQSHLCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKVDDPEFILEGALENHYGMLKQLKGVPGVRADRFVE
AGQVKHCALSLVGEPIFYPHINEFVKLLHKKRISSFLVTNAQFPDAIANMDPVTQLYVSV
DASTKESLKKIDRPLFRDFWERFLDSLDALGKKGQRTVYRLTLVKDFNTDEIANYAELIR
RGQPDFIEIKGVTYCGYGGASGLTMANVPYHAEVVRFVELIQEQLGAGYEIAAEHAHSCS
ILVASTKFKKGDTWYTHIDYDKFFELVESGEKFTSLDYMAETPSWAVFGAPEGGFDPEET
RYFRKTKEQRKAERERREDEEDQE
>A0A833E9D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MSSREVIKIPERIVNQLLNAHYGVYNHSTVEICHWTKKSLKNQGVCYKRVFYGIDSHRCV
EFSPAGMMCTMKCIFCWRPMEFMKKVDMAFEEVDDPIDIMEGLMKERSRLMSGYPGMPNV
DFRRLEESKEPTHYAISLSGEPTLYPRLPELVRYLKSLPSTRSVYIVSNGLQPDMIKRLM
DEDALPTQLYISMSAPNEEVMYRVDKPLYKDAWSRYIRTLELLSQADTRTVIRMTMIKDV
NALDEYIPEYVGLLEIANPNFIEVKSYMHLGYSTKRLKKSNMMSHEEIRRYARKILRRLK
GFRYMDEYPPSRIAVLQNMVRYVDRWIN
>A0A2D6L4R2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MIPEDISELLKRQHYVIAGKHSAVQVCRWTKKALTGEGVCYKQKFYGIKSYGCCQMTPAV
MWCPNKCLHCWRAIELTLGDKMENTDSAKEIVDKCIEAQKKLLTGFKSHKKIDMVKWEDA
QEPSQFAISLSGEPLIYDKICDLVEELRARNKTSFIVTNGLYPEKIQEMIDKNCLPTQLY
ISVNSPNKELYDRFHRSSMKDAWEKLNKSLEIMGKIKGRTVFRINLVKDLNMNASLEKKR
KQEKEPKDYPELYSEMIKKANPMFIEVKGFMSVGYARERLGYDKMPYHEDIVDFAKKILK
FLPEYKILDEHEFSRVVLLGKSEEGRKI
>A0A5E4HIR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MNSIPETTQSLLKKHGYHLAGTHSAVKTCLWLNKSIRNTGACYKSKFYGMTSHRCIQMTP
TLVCNHRCLHCWRAVEVPVQVPHVWDTPEEIVKAVFNEHKRLISGYGGSEFMDKTRWKEA
FFPKHVAISLSGEPTMYPYLPELIEEFHKNDMTTFVVTNGTIPDMVEKIKPTQLYISLNA
PDENTYEKACSPIGDSWENIKQSLEILKRSGTRTAIRITLTKGVNMVDPEGYARLIELAR
PDYVELKAYMHLGFSRKRLSQDNMPSHEEVLGFSGQVAEALEYRIADDSSGSRVVLLSKD
GGKHNI
>A0A5E4HN65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MLNEDARRELEKQQYRVVGGHSAVKVCGWAKKMLRGEGCCYKMRFYGVVSSNCLQMSPSL
SCANRCVFCWRGYKAPVAKEWGWSVDEPEAIVDGCLAAHHDLLVGFKGNSKVDRAAYDAS
KTVKHAALSLTGEPIIYPRINELINVLDERGISTFLVTNAQYPKQIRDLAPVTQLYLSVD
APTKELLKKVDVPLFPDYWERLNMSLEELSNKKQRTCIRLTLVKDMNMTEAEEYANLIKK
ADPDFVEAKGYMFVGASRQRLNLANMPTHEEALAFSQELLKHLPDYEIASDHPPSRAVLL
AKKKFKKKDGWHTGIDFEKYHTLATSKKEFTTDDYTKKTPAQRIEQDTGEPE
>A0A5J5MSZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Muntiacus reevesi|TrEMBL
MYPALDTWDFSSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNLQEKTIPKASQD
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPLAMINLKDYDPDD
HLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGARRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGEGKRCRGNCKKGKCESSQRGSEAAEPGSHVQEELHHRDAEEEEPFESSSEEESD
AEDRQSQNSVVDVEDLGKIMDHVKKEKREKEQQEGETGVTRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKAHHSPYSPGMLHISTHLAISAGVPSTFLENPDLVF
HGICVLHLLEEREDVFGPVWKFSKNRRQFLLQSNTK
>A0A0V0SFW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella nelsoni|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVFDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLNKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVCEVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKI
CRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTD
PAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISK
MHSLNISTFLVTNAQFPSAIKNLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSI
DILREKKQRTVYRLTLVNRYNMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKDSKITMAN
VPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAE
RFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A2Z7B4I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dorcoceras hygrometricum|TrEMBL
MSPPTRLALLTLLSASATLFFIYKSRHRYRGLLRRLLREPSTQNSPSSSRRGKLFFLSQT
NTSKTLARRLHTLLTLNDLPFDFVDPKDYEPEDLCKESLVVIVASTWENGGPPQNGSFLV
NWLTESADDFRVGALVLKDCKYAVFGVGSSSYVETYNAVAKGVSENLRKLGAIELVELGE
GDREEGNLDEVFHGWSDRVVGVLKGSIGENLGHFENGEAGSKIEGEFEFSDSEEEEETED
DPESGVVDLEDIAGKGPSRKSIMGTTANGKVNGEVVNGEKEMVTPVIRASLQKQGYKIIG
SHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGK
SWRWKMDDPLVIVDTAIDLHTKMIRQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPE
INALIDELHRRRISTFLVTNAQFPERIKTLKPITQLYVSVDAATKDSLKAIDRPLFGDFW
ERFVESLKALREKQQRTVYRLTLVKGWNTEDIDAYSSLFDLGNPDFIEIKGVTYCGSSAT
SKLTMENVPWHSDVKNFSEALAQKSNGAYEVACEHEHSCCVLLGKVSKFKVEGEWFTWID
YDKFHDLVASGKPFTSEDYMSPTPRWAVYGAEEGGFDPDQSRFKKERRHHKSAAKKLV
>A0A8C3QN26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyanoderma ruficeps|TrEMBL
MDTWSSFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKGEKSHGNPSSPEGAA
DKLGNGCATPQAQEVHVAGVKIFYGSQTGTAKRFARILAEAVTSLNLPVEVINMGDYDPE
DGLVEETSSRNICVFLVATYTEGQPPEGAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGKHGKESSDHEHGTSEQENTEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKREQELEEGAAGAGRKEEAERREMITPALRDALTKQGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKLDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMY
PHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGES
SASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWID
YSRFQELVGEYERSGGCRTFTAAEYTARTPPWALFGARERGFDPSEVRFQRRNQARDISG
C
>A0A8C2JIN3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MLFLRHVYKNYLHLLIELCKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYL
KGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADF
QAWKAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSEEELMES
SSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKTKVKTKPCRSTVVTYRYKLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMD
PAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRL
LHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
RALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMAN
VPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQ
EYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A2N9GM67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fagus sylvatica|TrEMBL
MSLSSVPARLTLLALLSASTFYCLYKSRRLRHLKLSLNPNPNLSVSKPKLFFVSQTGTSK
ALARRLYDLLAANNLAFDLVDPKDYEPEDFPKETLVLFVASTWDDGKPPPSAKFFANWLS
ESADDFRVGSLLLSRCKFAVFGVGSGAYGTTFNTVARDFSKHMRALGAMEILPVWEGDVD
SGDVDEVFHAWSAKMIGYLKGGVVENGGVLVSEVGGDLSDAESDGGGADEDEEDNEGGVD
SEIVDLEDIAGKAPLKKTVPTAETNGKLNGKKEMVTPVIRASLVKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDD
PLEIVNSAIDLHTNMIKQMKGVPGVTLERLMEGLSPRHCALSLVGEPIMYPEINTLVDEL
HRRRISTFLVTNAQFPEKIKTLRPLTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLK
ALLEKQQRTVYRLTLVKGWNTEDIDAYSNLFSLGNPDFVEIKGVTYCGSSATSKLTMENV
PWHADVKAFSEALALKSQGEYEVACEHVHSCCVLLAKTEKFKVNGKWFTWIDYEKFHNLV
ASGKPFNSMDYMAATPSWAVYGAEEGGFDPGQSRYRKERHHKSSH
>B1L5L5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Korarchaeum cryptofilum (strain OPF8)|TrEMBL
MLALGVSTPSHVRKLMEKQGYKFILNHSAVKPCYWFRKSIMEGKTCYKNKFFGIPTWRCI
QMTPTASFCNMQCVYCWRLNASDVPMSQRWVEVPEGKWDDPEEIAEESVRVHRMLVQGYK
GVRVFNKDWVREAEEPKHAAISLTGEPTLYPFIGGLVEAFSKRGMTTFIVTNGTMPERIE
GLEREPTQLYVTVPAPNEKLYAEITRPIWPDAWNRLMRTLELLQSLSCPTVIRIPLMKGL
NMDERTLEEFSELINRYQPTYVEPKAYEWVGYSRRRLNKWNMPWHHEVREFAYRLSDLTG
YKILDESEESGIVLLSRLERAIRFY
>A0A8H5V3L0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella subglutinans|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YDEPAEPKVVVEEKTPTIEPVEEKKNVRSQGPRRIKGGIARKPSKNKEEEKDTTRPVAPL
VFFSSITTKTAKIAEAYIADFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EVDGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVREVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSSRDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A4X2K3C0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vombatus ursinus|TrEMBL
MDASLDAWDHFYTPLISLWVNRFYVYLGLAFGVSLCICIQVVTKKLGDRSLGKSSLQKTF
PAPVAPVAPVANGPTSPEKKEVHVSGVNIFYASQTGTAKGFAASLAKAVTALDLPVVVIN
LKEYDPDDHLGEEVTSKNICVFLVATYTDGRPPDSAEWFCKWLEEASNDFRFGKTYLKGM
RYAVFGLGNSVYESNFNKVGKNIDRWLWMLSARRVMTCGEGDGNVVKSRHGSLEADFAAW
QARFLSRLQDLSRGSSGEKKACRGSHRRGSCEKGGCRVKKEGKGMGPAGPQREAPEEKEQ
FETTSEEESGAEDHQSRSSVMDVEDLGKMMSSMKKAKKEKEQQDIQLDLSRGAREKREMI
TPALREALSKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPDMILREAVENHQNMIKQFKGVPGVKASRLEEGLQ
VKHCALSLVGEPIMYPEINRFLKLLHQHRISSFLVTNAQFPTEIRNLEPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLNSLRALAAKQQRTVYRLTLVKAWNVDELRAYVELVSLGE
PDFIEVKFKIDGEWWTWIDYDRFQDLIHEYETSRGSKTFSAKDYVARTPPWAVFGASERG
FDPKDTRFQRKNKSKDISGC
>A0A4X2KB88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vombatus ursinus|TrEMBL
MDASLDAWDHFYTPLISLWVNRFYVYLGLAFGVSLCICIQVVTKKLGDRSLGKSSLQKTF
PAPVAPVAPVANGPTSPEKKEVHVSGVNIFYASQTGTAKGFAASLAKAVTALDLPVVVIN
LKEYDPDDHLGEEVTSKNICVFLVATYTDGRPPDSAEWFCKWLEEASNDFRFGKTYLKGM
RYAVFGLGNSVYESNFNKVGKNIDRWLWMLSARRVMTCGEGDGNVVKSRHGSLEADFAAW
QARFLSRLQDLSRGSSGEKKACRGSHRRGSCEKGGCRVKKEGKGMGPAGPQREAPEEKEQ
FETTSEEESGAEDHQSRSSVMDVEDLGKMMSSMKKAKKEKEQQDIQLDLSRGAREKREMI
TPALREALSKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPDMILREAVENHQNMIKQFKGVPGVKASRLEEGLQ
VKHCALSLVGEPIMYPEINRFLKLLHQHRISSFLVTNAQFPTEIRNLEPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLNSLRALAAKQQRTVYRLTLVKAWNVDELRAYVELVSLGE
PDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVEELVDLLPNYEIACEHEHSNCLLIA
HTKFKIDGEWWTWIDYDRFQDLIHEYETSRGSKTFSAKDYVARTPPWAVFGASERGFDPK
DTRFQRKNKSKDISGC
>A0A4U7AWF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Elsinoe australis|TrEMBL
MELFAELLSLWHEHRLELLVVAGVVLAFARFYYHNSSEEHEEPAQEKAEAAGLLFTREGS
KDKVATLPIVRPNPASRTKSEGPKRFTGTRKSSPDKSKDGQKRQEATEIEPIIFYFSLGG
STAKLAERLSEQFASLAKTELSLRTPQLHNLVEIDFDDYFASPEKTPASLQRFYMILIPT
YNIDSELTTFIDSLADTHNDFRIDTAPLSGLAGYSIFGVGDVEGWPTEQDGFCAQAAEVD
KWMARLTGKKRAYPTATSDIRAAEKTLSDWQKGVSEVMTGIAAGRGLGEGVKGSGEALES
DEEDLDSEPSNTTQPNKKRKRPSRTTTTTTDLEDIRAPTTTTSDLEIDFTTRTTPAAPKE
MVPLTSPTYTALTKQGYTIVGSHSGVKLCRWTKSALRGRGSCYKYSFYGIASHRCMESTP
SLSCSNKCVFCWRHGTNPVSTTWRWTVDPADLVFEGIKKGHYQKIKMMRGVPGVRAERFQ
EAMRIRHCALSLVGEPIFYPHINALLGMLHSERISSFLVCNAQHPEQLERLAHVTQLYVS
IDAATKEGLKRIDRPLHRDYWERFLRCMDILREKRDVQRTVFRLTLVKGFNIEEEVEGYA
DLVERARPGFVEVKGVTYCGTSTSAAAGLTMQNVPFYEEVCAFVEALNRALEKRGLGYGI
AAEHAHSCCILMGERERFYKEDGWHTLIDYERFFDCLESGEEFGPQDYVGEKTPEWALYG
NGGFDPRDERVDRKGRPKEVPQNERRVVEI
>A0A7C7PXQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aigarchaeota archaeon|TrEMBL
MAEIIPVTAVAKKQKREEVKLVEKFQQSGYRIIGRHSAVKVCHWTKSALRGDKMCYKHWY
GIDSHRCIQMTPSVQYCNLMCVFCWRFHTPNRVEPYDGSWDDPAEILDKMIEAQRQLLSG
FKGNPRVSRERYEEAINPKHIAISLDGEPTLYPKLAEFIQEAASRGMTTFLVTNGTMPER
LEELKRKGAEPTSLYISLYGPDKESHIRTNKPLIPDSWERILKSLEVMRSFTSRKVIRLT
LVKGYNMHSPEKYAELIKIAKPDFVECKGYMHVGESQKRLPKEAMPSTDEIVEFAKQLAG
ILGYVYVTEDNASRVALLADPSSRYYLEQLEKMRMEASLSTAEEPAVELTGGEGCGEIM
>A1CU36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)|TrEMBL
MTEHSLTEGLLTFWHSYRLLFLVAFSTGFVIIRFYRKFQTRSKTTASSSVPPSPRSASPE
KPDKPLLNEAVKPVATQNIESQTSLSNEPLSKAASGPKRVSGKKPLKVAGRRAQSDQGQP
ISFIQPIIFFASLTTTTERYAQTLLEDLRAAAQKRADLEDRERGLLPPQIHDLSYIDLDD
YFTSAPKPPSNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGALSSLAGYS
VFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGFGDVKSDAESALKEWSQGL
QDVLLDILENGGLGEGVPGSGDAVESDEELDDEDLENGVKGNNKRRKAQDVVDLEDIKFG
ADPQNTTGAPVPVDFTTTKQSAPAPATEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSP
ELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFLDMLH
EEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDI
LREKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLT
MQNVPFYEEIAEFVTALNSELQRRGLDYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYD
RFFQLLEKEKADGTPFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKQLQVTAEA
>A0A6G0X2H2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces euteiches|TrEMBL
MLVIQPVQAAALAAGLAIVSASIAYVLWKSEQEKAKSVSLQAKSASCCSGSSSTCCQTNE
QTVKPVAVRILYGTHTGTAKGFASALEKKLFALNVAGYAFEPSVVDMKDYDQDNLEHEQV
VIAILSTWTGGVPPESALVFCNWLQDMALDFRVSKTWLKHVHVGVYGLGNSEYDENYAKA
SKALSKHFSTLGATRLLPRGVGDDNQDQTAQFDQWSDNLVAALCEQYANLRQPSSAAKEF
LSTKEFRRQKRKEKAKDNEDSDNLTEEDRMNEIVLEDDEDEQPKAKGDGVMDVEDIGVAM
KESEAAALSREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGIT
SYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDEPKELVEGAISRHQNMINEVKGL
PGLIQSRWEEAFTVRHCALSLVGEPIMYPHINEFCRELHARQISSFLVTNAQFPEKIAAL
EPITQLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLEQLKAKGQRTVYRMTLVKEHNMK
EIDNYVELIQIGQPDLIEVKAVTYCGKSDASDLTIKHVPYHQEVREFCELLCSKLGGQYD
LATEHAHSNCVLLAKTTFKIDGQWHTWIDYDKFHALIQKYYADGTPFTTMDYIAPTPAWA
VYNAPEAGFDPVEQRFRRTKEGKVVEIEYTATDSGCG
>A0A7C3F3D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylicus mesodigestus|TrEMBL
MVLLPEILGALRSQGYHIVGKHSAVKTCHWAKEALTGGEMCYKGKFYGISSHRCIQMSPA
VAHCTNMCAYCWRLLPSEHGIEWDGSRILSEDSPEEIAEGAVRAHRRALNGFKGHPNVSL
ERFEESRSPRHVAISLSGEPTAYSGLDGLIGEFQRRGLTTFLVSNGTNPAALGAIREPTQ
LYISLSAPSEELYRRVCRPTAPGSWGRLIESISMLPSFSCPTVIRLTAVKGLNMEDPEGY
SRIIMRGSPSYVEVKAYMHVGFSTTRLGFGAMPSHAEVMGFAGELADLTGYEIVGDVPIS
RVALLSRIGKPKRVS
>A0A836HJ03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania martiniquensis|TrEMBL
MIAFFLQLLVSAALPLLAWLLYNHLADSAHAVDIVTSSDTGAVKKVDVFTREVEAELEML
GVAPTPPSAESVQSALPPKERAPSPAATAAAEAVPTAPAPAEILIAYATQSQNSLALAHK
LFSSMTAQLHTSSTPTTEGAVCPLVRVMEIYEDDGSGSGATAVAASGRAGRTNVCRVDTL
LEDNQYALVIFIVSTYTDGVAPPRSRVFEAMLKDAFEDHRVPRNALSRKRFAIFGLGDIA
YGEARFNAFAKNVHEWCRGLGAPPFVVPPVYATEAKTQSLFRIFSTALLKWLSRATFHSD
GTVTVQKKSEVAVAGSVGASAMGARRRRPRSAAASAEEAAGDEGVLCACQQSSQQPCASR
AKAGGEADCACCKTQLAASGVAASKSDGDDDDDANAEEDMEDVEDLVWDGTDDADFDVSK
DPDELPELLYPKLRQSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYNIDSSQC
MEMTPSLACANKCVFCWRHHTNPVSRHFRWRQDPPELLIAQGMAGHYEMLKQMRGVPGVT
PERLAAAMHIRHCALSLVGEPIMYPQINRFCALLHQHRISTFMVTNAQFPEQLRDLQPVV
QLYLSIDAPTPEELKRIDRPLFEDYWDRCLSCVKELAKKRQRTVFRLTLVNQYNTENVKA
YADLVEMGQPDFIEVKGVTYCGTSPSSTLTMKENVPRHDEVMEFCRALCAEVARRHPHYR
TPQMDAEGEGGSDAIVIPVGERNRPYHVACEHEHSCCVLIALDTFFFEGRWHTWIDYERF
YDLVESGRTDFTSLDYAAVTPAWATCNSKEKGFDPEQTRVVRKNGRPTIVTASC
>A0A8E2ERB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glonium stellatum|TrEMBL
MGSLQSMWELPAELLALWHSHRIPILLSTISLLAIVRLALYLRRSRPKLSVSPVPGSPTG
KSKGVDPTWLNSTTIPPDPIAQADDHAKDGKIVTGLDSKLKKGPKKVIGTKLRRKASNQP
AGFNCTTDRVQPLIFYSSLSGTTEKYASQLAEDISSWVGDSKSPLPLCKPELHDLSYIEH
DDFFISLPKAEPDTKHLYLILLPTYNIDTVLSTFLENLQETHNDFRIDTAPLSGLLGYSV
FGFGDKEGWPTEEEGFCSQAREVDKWLAKLTGRKRAYPLGMGDVKGDAQERLKEWQLGVQ
EVLTEIASGRGLGEGVPGSGDPAESDEEDVDEMEDSDEEETASKKRRKPQKAARLDDLED
LGRMVNIDNVPSQPPLSVDFTTYSSPKSKTSVSVPPKEMVPTTSPTYAALTKQGYTIIGS
HSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTT
WRWITDPPQVIFDGITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHI
NELVNIMHANRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFCACLDILRERRFAQRTVFRLTLVKGFNMADEVRGYADLVQRALPAFVEVKGVTYCGTS
AAGSAGLTMQNVPFYEEVAEFVAALAKELVERGLGYGIAAEHQHSCCVLLADEERFRRRG
RWATRIDFERFFDLWEGKVEGTGVDGKGWRPEDYVGEDTPEWALWGNGGFDPRDTRVWRK
GKGKKALEEPVEAEGGCG
>A0A1H7N5K0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter gottschalkii|TrEMBL
MSFNENQIQKLEKSGYRFVGKHRHAAVKTCHWTRQSIVEKGVCYKEKFYGIQSHRCLQMS
PAVPNCQQECEFCWRDLTHTQTEWEDNEYDDPKTIVDEAIETQNNLLCGYYGNDKANKKK
LEELKKPTNAAISLAGEPTLYPKIDELIGEFNHRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPNEKIFNEVCRPRINDAWNNLNESLETLSSFNSRTCIRNTCVKGRNMEQPEKYA
ELIKKADPDYVEVKAYMCVGSSRDRLTLDNMPTFDEVKSFAKRIGDECGKELVNESEISR
VVLLE
>A0A1L9N713|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus tubingensis (strain CBS 134.48)|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKKNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPSPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKTIQAAAEAQG
>A0A7C1E2R2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MRAISKYAEGALLTLERQGYHFVGTHQHSAVKTCLWLRKSLRGEGNCYKGKFYGIRAHRC
VQMTPSIFCNQRCVHCWRPLEAVTVDRDEVAVIWDPPEEIVEACLQEQQRLISGFKGSAK
TSGELFEEAMNPKHVAISLIGEPTLYPQLTELIEQFKARGMTTFLVTNGTKPEMIRSIRP
YQLYLSLNAPDESTYQKTAHAHLWHQVLDSLEVMHQLKGQTRRVIRITCIAGMNMLNPAG
YAALVGRASPDFIEVKAYMHLGYSRKRLTRAAMPPHARVRAFAAAIADELATVGYPYTVA
DESEISRVVLLAAQP
>A0A131XHP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyalomma excavatum|TrEMBL
VMLENVARFFVTSILSALLIFHTVHAKGSVNEKSTSDWYPSSYTTTLCGGVLAVLFFVVA
REKLNLSKIKTQDPFKQRPRKRNGKSVKVLYGTQTGNAKILSEKLAAELDALDYDVEIIS
LKHVEPEECLLGQVKAKGLCIFIVSTYVDGSPPDEATWFYDWLKDTYADFRVHKYYLQGL
SYAIYGLGDSAYGDSYNKVAKDMDFWLSKLHATPVVPLCLNDESHDEGKYGTGKFSGWKD
DVVAHLKGSPLITTQPFEPQIAPDDAAYESSSDEGEPDVVDLEDLGNVRSSAKLKESKAS
KNGEARPDMLTPLLRQSLGKQGYRLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHR
CMEATPSLACANKCVFCWRHHTNPVGTEWKWNMDSPEMIVENALKNHYKMINEFKGVPGV
LRERLDEGLRARHCALSLVGEPIMYPEIGKLVRLLHDKGISTFLVTNAQFPDALRELGPV
TQLYVSVDASSREALKRIDRPLFPDFWQRFQDSLCALAEKGQRTVYRLTLVKEWNMDEMQ
GYANLVELGKPDFIEVKGVTYCGDSKGARLTMSNVPWHEEVLSFVKQLAALLPDYSIASE
HEHSNCALIAHNKFCVDGQWNTWIDYERFHELVQRFYQTGESFTSLDYMAPLPHWAVFGA
KERGFDPSDTRMLRRSKKDISGC
>A0A1D2WN90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp. A27|TrEMBL
MSFNENQIQKLEKSGYRFVGKHRHAAVKTCHWTRQSIVEKGVCYKEKFYGIQSHRCLQMS
PAVPNCQQECEFCWRDLTHTQTEWEDNEYDDPKTIVDEAIEAQNNLLCGYYGNDKANKKK
LEELKKPTNAAISLAGEPTLYPKIDELIGEFNHRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPNEKIFNEICRPRINDAWNNLNESLETLSSFNSRTCIRNTCVKGRNMEQPEKYA
ELIKKADPDYVEVKAYMCVGSSRDRLTLDNMPTFDEVKSFAKRIGDECGKELVNESEISR
VVLLE
>A0A1V4V1U4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaB.Bin039|TrEMBL
MEDSSEHTAALVRQGYHMVGHAAVKPCLWLNRSLRGEDQCYKHHFYGISSHRCIQMTPVL
HCNHLCMHCWRPVDQPIALPREWLEPDDLLQRVVMEQRRVLSGYGGSPVLDRERFEESKV
PAHLAISLMGEPTYYPMLDELIDAARRRSMTTFLVSNGTRPEVLERVRPTQLYLSLSASD
REQYLHAAHPSRDDWDQVLSSLHLLGDHASRTVVRITLVKGFNMDPEGFFSLLKEAGPDF
IEAKAYMHLGKSRGRLTREAMPSHEEVMAFSLRLAENLGYSLSGEVPLSRVALLTNNRRP
RIIEEH
>A0A836H7P4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania enriettii|TrEMBL
MIGYALQILVSAGLTFVAFLLFNCLADSAHARGNVAASDTDAAGNADVFSRQVRAELEQL
GVASTPPAAGPVQSAPPPVEKTPSPAAAVAAEAAPTAAAAAEILIAYATQSQNSLALAHK
LFSLITAQLLTSPMRTTEAAACPLVRVMEMREEDSNGSGATAVASGGRVGSKNVCRVDTL
LEENRYALIIFIVSTYTDGLAPPRSRAFEAMLKDAFEDHRVPRNALGRKRFAVFGLGDIA
YGEARFNAFAKNLHEWCRGLGAPPFVVPPVYATEAKAQSLFLIFSTALLKWVSRSTFHSD
GTVTVQKKSEVSVAGSAAAGATGVRSRRPRSVAATSTANASMTSAAAGEALGNESASCAC
QQSSGQSCGDGAGAGDEESCGCCETEPARNGVAASKSDDDDDDANAEKDSMDDVEDLVWD
GTDDADFDINKDPNELPELIYPKLRQSLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYK
HTFYNINSSQCMEMTPSLACANKCIFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQM
IKQMRGVPGVTPERLAAAMQIRHCALSLVGEPIMYPQINRFCALLHQQHISSFMVTNAQF
PEQLRDLQPVVQLYLSIDAPTPEELKRIDRPLFEDYWDRCLSCVKELAKKRQRTVFRLTL
VNQYNTDNVKAYADLVEMGQPDFIEVKGVTYCGTSPSSTLNMKDNVPRHDQVMDFCKALC
AEMASRHPHYRTPQMDRDEEGGDDVIVIPAEERDRPYHVACEHEHSCCVLIALDKFFFGG
RWHTWIDYERFYALVESGRTDFTSLDYAAVTPAWATCNSNERGFDPEQIRVVRKNGRPTI
VTASC
>C7P5V9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus fervens (strain DSM 4213 / JCM 15782 / AG86)|TrEMBL
MIPEEIYKILRRQRYQIDNHTAVKLCGWVRKKMLEDKSCYKSKFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPRDIGIDVSKIKEPKWDEPEVVYEKILAMHKKIIMGYKGVLDRVGEK
KFKEALEPKHVAISLSGEPTLYPYLDELIKIFHKNGFTTFVVSNGILTDVIEKIEPTQLY
ISLDAYDLESYRKICGGKKEYWESILNTLDILKEKKRTCIRTTLIRGLNDDILKFVELYE
RAEANFIELKSYMHVGYSQKRLKKEDMLQHDEILKLAKILEENSSYNLIDDSEDSRVALL
QNENRKINPKIFE
>A0A5N5GVI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrus ussuriensis x Pyrus communis|TrEMBL
MFLSSAPARLTLLALLSATTVYCFYKSRRLRRLKLSLNPNPGSSPRRGKLFFVSQTGTSE
ALARRLLDFLKLKGVAFDLVDPNNYEPEDLPKETLVLIVASTWDDGKPPPNAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDLARRMRALGASEMFPIWEGDVD
GGDLDEVFDAWSGKVVRFLKGGAAENGGVLGNGVSDECEAESFDVSDEEDEEEEDGGESG
VVDLEDIAGKGPSRRNPVAATKTNGTVNGKKEMVTPVIRASLTKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
LEIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALIDELH
QRRISTFLVTNAQFPEKIRMLNPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLTS
LKDKQQRTVYRLTLVKGWNTEDIDAYYNIFSLGSPDFVEIKGVTYCGTSATSKLTMENVP
WHADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTSKFKIDGQWFTWIDYEKFHDLVA
SGKHFDSKDYMAPTPSWAVYGAEEGGFDPYQSRYKKERHHRTNQ
>A0A7K4IF99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MTMPSELELRLRRQGYHILGGHGAFKACQWQRKSLLEGRSCYKERFYGIASHRCLQMTPV
VDKCTQQCRFCWRVTPSDIGVEWDQLTTNRGSILEPDDLIDAVFEANLRSLGGYNPAVAP
SVKPEKWREAREPKHIAVSLAGEPTLYPYLSDLIDAIRQRGMTSFVVTNGTMPEVIADMT
PPTQLYLTLAAPDEETYRNLCRPIVKGAWERVKESQRMLGSLNCRTVNRLTMVASWNMGD
VESYSKLIRMGEPNFVEAKGYMFLGFSRSRMSRANSPSHDIIREFSERLSDSCGYYLIDE
QVESRVVLLSRSKEIKKLEHT
>A0A523RSV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPSELSEKLEKQGYHLLGKRGAYKACQWQKKALLNGNACYKQRFYGIESHRCLQMTPVVD
KCTQSCDFCWRVTPSDIGTKWDQVTVDETDVIPVEDLMDAVLMANLRTLGGYNPKAGAKV
SERMYKEAREPKHVAISLAGEPTLYPYLSDFINEIHDRGMTSFLVTNGTLPNVLSGISLP
TQLYLTLAAPDETTYKTLCGPGIKNGWNNIKESQELLQSLDCRTVNRLTMVANRNMHNPH
AYSRLIEMGEPDFVEVKGYMFLGSSRRRLDKSNAPSHREIRAFSKKIATLTGYHLIDEQV
ESRVVLLSHTKQIKKL
>A0A497H4Q8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MSSDIRKLLEDQRYALVGEHSAVKLCHWLRKSLLEDKPCYKHTFYGIESHRCLQMTPAVF
HCTQKCLYCWRYQGFTLTEMSGTVDEPSDILQQCLDAQYRLLTGYKGDERVSSKKWREAI
EPKHVACSLTGEPTLYPFLSDFFEECHKRGMTTFLVTNGTVPEALEKMDTLPTQLYVTVA
APNEDIYKKICCPLIPHAWEKLNATLELMPSLDTRTVIRHTLVKGWNLGYETEYAKLDEK
AHPWFIEPKGYMFLGYSRQRMTMEHMPSHEEIRAFAERMASVTGYTIESERRDSRVVLLG
RGKERFIT
>D2PJU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain L.D.8.5 / Lassen #2)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A851Q005|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anhinga anhinga|TrEMBL
LDVSMDSWNFFYTCLVSLWLHRFYIYSAVAFGISIWIAIQFTTTKTKKKVTEHGEKSSGN
PAASEGIEDKLVNGYATLRAKEVLVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
NMGDYDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WKAKFLSRLQALCRGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGASEYENTEAEELFET
SSEGEADTEEAGGTNSVVDVEDLGNIMSRMKKAKSEVATRSSGSHPVLDKGVPNIACVKI
DGLIYFLFSGYKLTGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAK
HCALSLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTK
ESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPD
FIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLILDYEIACEHEHSNCLLIAHK
KFKINGEWYTWINYDRFQELVQEHERSGRSKTFTAADYTARTPRWALFGSRERGFDPLDV
RYQRKNKVRDISGC
>R4W7T1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salinarchaeum sp. Harcht-Bsk1|TrEMBL
MSDADGPKQVDDPDYHNVNHTAAQTCGWTKNALTGDGTCYKHAFYGIRSHRCIQMTPVVK
CNERCVFCWRDHAGHAYELEGVEWDDPEAVVDASIELQRELLSGYKGNDNVPDDRFEEAV
EPRHVAISLDGEPTLYPYLPELIEAFHDRGLTTFLVSNGTRPEVLAECDPTQLYVSVDAP
DRWTFDQTVKAVEDGAWEQLIDTMDVLAEKDETRTVLRTTLVDGHNMRDPDWYAAFYQRA
DPDYVELKAYMHVGHSRGRLDRSNMPEHEDVVAFTEDVMEHMPEHDVLKDRPPSRVTLIS
REEDTWVPKLQAGAEFWNAPDPSERAAVTDD
>A0A7J2SH07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MSLPEDSKKILQNQGYGIVGRHSAVKLCHWLRKSLLEGKQCYKNTFYGIESHRCLQMTPS
AFHCTQKCVYCWRFQGFTLTKLEKKDTDEPRYILEKSIEEQYRLLTGYKGDNRVSIEKWK
EAIKPKHVACSLTGEPTLYPFLSDFFEECHKKGMTTFLVTNGTNPSALEKMDTLPKQLYV
TVSAPNEEIYKKVCCPLVPKAWEKLNETLEILPSLNTRTVIRHTLVRKWNLGYEKEYAKL
DKKAEPWFIEPKGYMFLGYSRERMNIENMPSHEEIRKFGENLADLTGYKIELEREDSRVI
LLGKGKERRIK
>A0A292PVA8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tuber aestivum|TrEMBL
MAESQTHTAREFLVLKLRSYVRNSEQRESKGLTPLKPTTWFEVPVKAESDPAVKRHHAPR
RVVGKKDGFKPKNGGKVASEVEEGEFDIQTLIFYSTLTGSTQRCAEALRTRLFSVKGESI
YPTLSIPTPSNSLGSVPIRRSFLPPTVYNLEEVELDDFFITPPGGNGKRVKYVYLLLLPT
YETDSPIRPFLEHLRETHHDFRIDTAPLRSLAGFSVFGFGDSSEWPAEEGKFCKDAVEVD
KWMGKLTGGKGGTRRMFPVGMGDVNPAAGLDSAEESLDEWRVHLEDAMREYAVTGTLGDS
ADWRTAIESGDEDSDFEIVDPADDMVDVEDLGNVIRKSPAITKNDGATKKRAVLPVDFTT
PAGRKALEAGEGQSADRKEMVPKGGVTYEALTKQGYTIVGSHSGVKICRWTKSALRGRGS
CYKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEEIFKGVVEGH
YRKIKMMKGVPGVRADRFSEAFKIRHCALSLINEFLHLLHSSKISSFLVCNAQHPAQLAA
LGHVTQLYVSIDASNKDSLKKIDRPLHRDFWERFQQCLDILREKRNQHRTVFRLTLVKGF
NIEDEVQGYADLVEKGLPCFVEVKGVTYCGTSTAGEAGLTMKNVPFYEEVVSFVEALNAE
LGKRGLGYGIAAEHAHSCCALIASNRFLVNGKWHTLIDYAKFFELLESGKEFGPEDYIGE
ATPEWANWGNGGFDPADQRVYRKGKGPKEEVEESGGCG
>A0A1L7TXW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium mangiferae|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVIEEKTPTIEPVEEKKSVKSQGPRRIKGGIARKPSKTKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKGDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A852E7N1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vidua macroura|TrEMBL
LDVSMDTWSYFYTCLVSVWLHRFYIYSAVAFGIGLWVVIQFTTTRTKRKKSHKNPFSPEG
TSDKLGNGCAPLQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDSNVAQSKHGSIEADFEAWKAKFL
TRLQALCRGEKKPCSGKCKKGKCKSSGRQSKESSDHEHGTSEQENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNVHGVNHSGYHLVYFVCQFLQAKLICLMI
CALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPELILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCAL
SLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLR
RIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFVEV
KGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQV
DGEWRTWIDYGRFQELVREHERSGGSRTFTAAEYTARTPPWALFGASERGFDPLDVRFQR
KNKARDILGC
>A0A1X0SFF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus microsporus|TrEMBL
MTLLATLTVLEEVTYVIYLLLSFFCLKKVPKVSRRLFEYNELQAFPDLDVFDLCVATSLL
KSPLMSNFFNSLIYNFSNILSIGPEPPREGEEQCGTGCCKEQQSNNEGCCQGSGNSNGCC
KDNNQILEIESVKILYSSLTGTAKTFANEVEEKLKSTKFVKIQKLETMDITDYDNDNLLN
ETSVCIFILATYNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNV
AAANIDKWLGRLGATRIYPLGECDKNADQKAQFDVWSNGFISELQDKHTLEFAPTNIAYQ
SDDDDEEAEEAEATGLEDEMVDLEDMGKMATKIKAAKAKRAEEEEDFEDSKAKAKRAIGE
DAKKQEKPQAREMVSPMILKNLTKQGYKVVGSHSGVKICRWTKSALRGRGFCYKHAFYGI
QSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLKG
VPGVKAERFQEAFTIRHCALSLVGEPIFYPHINDFVNMLHERNISSFLVTNAQFPDKIAE
MVPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNT
EEIDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRKLVSKLDGEY
EISAEHAHSCSLLIAHKSFKVNGEWYTHIDYPKFFELVKSGKPFTSLDYMAKTPEWAVFG
HEAAGFDPDETRFYRKNRKNVEPPVIKTEA
>A0A7K9H4R4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Loxia leucoptera|TrEMBL
LEVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRDKRKGEQSQGSPSSP
EGTSDKLGNGCAPRQAQGIHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVDVINMED
YDPEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCRWLEEAANDFRVGKNFLQGLRYA
VFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDK
FLTRLQALCRGEKKPCRGKCKKGKCKSSGKQSKESSDREHGTSEQDNTEAEELFETSSEE
EAGSPDSVIDVEDLGNIMGHMKKAKVLLLEGVWNAAGAERREMITPALRKALTKQGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TKWLWRMDQPEEILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYP
HINHLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDF
WQRFLDSLKALAEK
>A0A7R9FRK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Darwinula stevensoni|TrEMBL
MHLQRFIEALELMALVERSSMASGVATDDVEDEDAARHFWLSLSFSGRIFLQLCSFWTIE
EATRDNQLGMNLLKALWPRGQRLAHRAGTSSSLTMEEMLKRIRSYLVPHSDKAMLDPKQI
PQTQAELPERRMQDSFCEVVLPLGSNKDLHPRYLTKAGGVRIGRLLEDMDVFAGWVALHH
LLDMKAIETRPLPYSLVTALVDQIRFVKGRISPDRDLRLSGHVSYVGKSSLEVSLALHQF
GEKPYPWNLITHALFVMVLRDVIRDRPVPANPLRLASDLELKLYNQGKNNAVRRMTDTEE
SLLRKPPTEQERFIIHDLFLQTLNSEKHTFQSRVRPPGYIWMEDAKLKKVVICHLEDRNQ
LGKIFGGFIMRQAFELAWANAYVVSRQAPTIEFIDDIWFRRPVEVGSLLYMASQVVFTEG
CCMQVRVCAQVVDPESGEQQETNTFHFTFVVSKEVDQMLPKAYHESMLYLEGRRHFVSRS
DRQEEEYCGFAFHGHLEKATRDNQLGMNLMKALQLRGQHLARRMSTNTSLTMEEMLKRIG
SYLVPHSDKAMLDPTQIPLTQAELPERRMQDSFCEVVLPLGSNKDLHPRYLTKVGGVRIG
RLLEDMDVFAAWVTLHHLLNPKVDESQPLPYTIVTALVDEISFIKGKVSPDRDLRLSGHV
SWVGKSSVEVSLALHQWGQEGQPWNLITRALFVMVLRDAIRDRSVPANPLKLGSDSEILL
YKQGEANALRRKNTREESLLRKPPNEQERIIIHDLFLSTLDPLRHTFQSRVKPPGHMWME
DAKLKNVIICHAEFRNRFGKIFGGFIMRQAFELAWANAYVVSRQAPTIEFIDDIWFRRPV
EVGSLLYMASQVVFTEGCHLQVRVSAEVMNPVDGQKEETNVFHFTFVVPKEVDRMLPKAY
HESMLYLEGRRQFVARCEMWAFLGLPAVSGFTGALFGLLVLFVIWMFLNSDKSVGKSASE
SFEKAEPPTGLAESPTGKVEAPTEKVEAPLGQEQGKSKVKKAKKSCCSDGGTCCSKKDEN
LVKVLPSIQRVLLLYGSQTGTAQRFAEELYEYLGSLGLDIQIHGMKGFDPEDRLVDEVRI
IVSRCGSRACLAADGLLEGTAFLFLLSTHTDGGPPESAEWFHRWVVDAAEDFRVDHTLLQ
GMVYAAFGLGNSAYGPDFNKASKDLDMALVKLGAKYFVPLTLGDEDGTASANGGLDEDFA
EWKKRVRAALFGSNEAGNQKKKKDSGHQCGCGSKDGKGGGDGHQASLGISLAGRCQELLS
RLVSFNLSSIAVVVGKRYRVTWGEEVLSRCWSRWETVLLVFKAISFEYPWQSGSCSSECS
SDEDEGKDEKGGGEKVMDMEDLGSYMSQLLSSKKGKRTMGKRTTPEGHGENGVKEMITPE
LREALTKQGYRLVGTHSGVKMCRWTKGLKFTFALSHDANFCWRHHSNPVGTEWRWKTDDP
EDILSDALQHHYGLIRQFKGVPGVKADRMEEGLAAKHCALSLVGEPIMYPHIDAFLRLLH
RRRISSFLVTNAQFPQPMRWVPGPRKTDSLCLSVKTESRELSPVTQLYVSVDAATKERLK
SIDRPLFRDFWERFLECLEVLKDKGQRTVYRLTLVKGWNDEEIEAYARLVNLGSPDFVEI
KVGLLNRSVTVRYRAGVTYCGTSKNATGGLTMEHIPWHEEVVRFVEALQRHLDEDYDFAC
EHEHSNCVLLAHRKSVRSVHRMLQFRANGEWQTWIDYDKFQDLVEEYYESGGSKSFTSLD
YTARTPPWALYASAERGFDPRETRHRGKGKGKGQRPKDGGC
>A0A522XWN9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis sp|TrEMBL
MSCSGEIVEPENDIIQIKSSIQEQLKKAKYGVSDHSTVELCHWTKKSFKNEGSCYKHKFY
GISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLEMDSSKVAEPEEILTKLMKEREKLIM
GHYGDPKSDTKKLDESLLPSHYAISLSGEPTMYPKLPDLIKYLKSLKATKSIFLVTNGQE
PDMLQRLSDEDALPTQLYLSTNAADYNSFIEINKPRYKDSWERWNRSLEMLAKLDTRTVL
RVTLIRNYNNSDQMIPAFSEMVKRSDAHFIEIKSYMHIGRSTNRLDRSDMLEYEEVMHFS
SELAKQSKIYSIMDDSQVSRIVVLQNNQRFIDRWIPAYQTI
>A0A1X0R9I6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus microsporus var. microsporus|TrEMBL
MSNFFNSLIYNFSNILSIGPEPPREGEEQCGTGCCQEQQSNNEGCCQGSGNSDGCCKDNN
QILEIESVKILYSSLTGTAKTFANEVEEKLKSTKFVKIQKLETMDITDYDNDNLLNETSV
CIFILATYNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAAN
IDKWLGRLGATRIYPLGECDKNADQKAQFDVWSNGFISELQDKHTLEFAPTNIAYQSDDD
DEEAEEAEAIGSEDEMVDLEDMGKMATKIKAAKAKRAEEEEDFENSKAKAKRAIGEDAKK
QDKPQAREMVSPMILKNLTKQGYKVVGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHL
CMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLKGVPGV
KAERFQEAFTIRHCALSLVGEPIFYPHINDFVNMLHERNISSFLVTNAQFPDKIAEMVPV
TQLYVSVDAATKESLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNTEEID
GYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRKLVSKLDGEYEISA
EHAHSCSLLIAHKSFKVNGEWYTHIDYPKFFKLVKSGKPFTSLDYMAKTPEWAVFGHEAA
GFDPDETRFYRKNRKNVEPPVIKTEA
>A0A8J7Y617|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theionarchaea archaeon|TrEMBL
MDHELKNLLKRQHYRIVGNHSAVKLCHWLRKSLLEDRFCYKQKFYGINSHRCLQMTPAVT
ACTQKCLFCWRPTQFTEPALPEYDPPDLIVEESLEAQKALLAGYFGLPERVSAKKLKEAQ
YPNNVAISLSGEPTLYPELSELIHHYKARGMTTFLVSNGTNPGVLESLELPWNLYLTLAA
PTEAIYRALCHPQTEGWSKIMETVSLFSQLETQRVIRLTLVNGINMVHPEMYAQLIEKAA
PDFVEAKAYMFVGYSRHRMTIENMPSFSQVEAFAHAVEDYSSYEVCDSQSESRVVLLRRL
>A0A370LKT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crenarchaeota archaeon|TrEMBL
MSCSGEIIEEEELIQIKPNVMQQLKKAKYGVSDHSTVELCHWTKKSFKNEGDCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLAMEPEKVAEPEQILTKLMEEREKLIMG
YYGDKRNDKQRLDESRLPSHYAISLSGEPTMYPKLPELIKYLKSLKNTKSIFLVTNGQEP
DMIQRLADEDALPTQLYLSTNAADYDSFLKINRPRYDDSWERWNKTLGMLKHLDTRTVLR
ITLIRDYNNINEMIPSFAKMINESSPNFIEIKSYMHIGRSRNRLERDNMLEFNEVEQFSK
ELVQQSKMFSIMDVSTISRIVVLQNMERFIERWIPAYQTT
>A0A1I0EQ15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena hispanica|TrEMBL
MSDSAPSGADADEDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIFYGIESH
RCIQMTPVVRCNERCVFCWRDHNGHAYELDDVEWDDPEAVVDASIKLQKKLLSGFGGNEE
VPREVFDQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLRECDP
TQLYVSVDAPERHTFDQVVGAMEDDAWAKLLETMAVLADKDETRTVLRTTLVDGENMHHP
DWYAGFYQQADPDFIELKAYMHIGHSRGRLDRSSMPDHEAVMDFAESVADHMPEFDEVMG
VPASRVALLSKTSDTWVPKLKKGSEFWNRDPVTGD
>A0A523BHU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MRRQGYQLILNHSALKPCSWFREAIMRGRTCYKHKFFGIPSWRCIQMSPSIYCNFQCLHC
WRTNASDLPPEMRWKEIPDESYKWDDPEEIAEESIRIQRMIVQGYKGVKVFSKKMLEEAE
NPKHAAISLTGEPTLYPYIGELVEAYKRRGMTTFIVTNGSMPDVIEGLSTEPTQLYITVN
SPNRESFNRISRPLVPDAWDKVVKTLSLIKSLTSPVVMRITAIKGVNMHLAKEFAELIDK
FEPTYVEPKGYSYVGYSRRRMSRENSPSHEEVRSFAKEIANLTSYKIIDEQKESKVVLLS
KLDKPIRFY
>A0A099P6D2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pichia kudriavzevii|TrEMBL
MNEHIVALGAFAAFLYLAGKLGLLLLIVMCVGLMYCSKDVANGGDSVKRRSRRGNKSKVI
PPSITKMRKAKDGEELYTGSQNPLGESPIYIFYSSLTGASKRVALQLYDTLNASLGAPLS
LVVKLLSLDDDVEDLDDYFLNVPKLDKPPIYLLVLPSYESDSPIDYFLEMLRETSTDFRV
DKYPLRALAGYAVLGLGDSESWPELFCYQGKLADKWLSKLGGRRVFPFGELCVKSSNFKK
SCEEYTKRLVDLLLDDDPFLYEEDDDDDEDEDASMDEEQLANSDDDGNGGGSSDDGTLVD
VEDLQRNEKRVNLVDKKKMVAKDSPTYKSLTKQGYTIVGSHSGVKICRWTKSALRGRGFC
YKFAFYGINSHRCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWEVDKPDMILNGALEGHY
KKIKQMRGVPGILIDRFNEAFKVRHCALSLVGEPIFYPYINQFLEMLHDKEISSFLVCNA
QHPDQLSTLGKVTQLYVSIDAPTKEELKVVDRPLFRDYWDRLERCLDILRTVQSHQRTVF
RLTLVKGFNMSDESVGGYADLVERGLPALIEIKGATFCGSSEGNGNPLTMQNIPFYEECV
KFVKRVNEELNNRGLEYGLACEHAHSCCFLIASKKFLVDDKWYTHIDYERFFELLKSGES
FDKMDYISETPEWAYFGSEQGGFNPDDTRWNRKEEKLKKKAERERVAATATATATTAVDV
VVDGPN
>A0A7C5VT10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLAPSSLISVLKRQRYHIVGRHSAVKRCRWLYEALINDRPCYKQKFYGIKSHQCIQMTP
VLYHCTQRCLFCWRAQSGDLQIFWDETKLPQWDSPEEIVEGCINAQLQILSGYKGNPKAN
PQKFKEALIPRHVAISLTGEPTLYEPIGDLIGAFHKRGFTTFLVSNGTVPSALAKLSHEP
TQLYISLCAPNEEIYNKVCRPLQPDSWRKLNETLELLNSFKCPTVIRITAVRNLNMEPIS
DYAKIIEKANPTYIEPKAYMHVGFSRLRLGYENMPSHREIREFALQLAKELSYNFVDESE
DSRVVLLSRLKSPIKFSK
>A0A0F7PAS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halanaeroarchaeum sulfurireducens|TrEMBL
MVMAEQVDGPNYHAHNHTAVQTCGWTKNALRGEGTCYKQAFYGVRSHRCIQMTPVVRCNE
RCVFCWRDHGGHDYELDGVDWDDPEAVVDASIDLQRTLLAGFGGNDDVPRERFEEAMEPQ
HVAISLDGEPTLYPHLPELVEAYHDRDITTFLVSNGTRPEVLAATDPTQLYLSVDAPTPS
VFEDVVRPLEDDAWETLLESLDVLAEKTSRTTIRTTLVAGENTGDPAGYAALYERGDPDF
VEIKGYMHVGRSRDRLDREAMPTHEDVSAFADRVQSHLPAYDVKREAPPSNVVMLAKRPD
TRIDELATTEG
>A0A1V0N5I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ferroplasma acidiphilum|TrEMBL
MINNYEAVYKKQHYGLVGSHSAVKVCHWTKSELLGKAPCYKNTFYGIKSHQCIQMTPALN
QCSENCDFCWRFQGFDSMHINEEDDPEFILEESIKAHLKLISGFKGNPKVKKELFEEASH
PRHMAISLTGEPTLYTRLGELIEAATRRGITTFVVSNGTMPKVLETLNPLPTQLYITVAG
PTKEIFNDVLHPAIGNAWENFNKTLDLLPSLDTRTVIRHTMVKNVNFPFYDEYEKMDRRA
DPDFIESKGYVHVGQSEGRLTAENMPSHDEIMEFSSTLAKRLGYTEYADRFESRVAMIAK
HPEDAKIDVDREIRKTLDKLEITEN
>A0A2D6RB42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MQNPVTKIEPEIAARLAKQSYHLVGEHGGVKVCHWTKQSLVADRSCYKGTFYGIESHGCM
QMAPNVDTCNLACTYCWREPHSDALTKIDDDPYELFLQSVKAHRRLLTGFGGHPSVPREK
WLDAQDPKHVAISLNGEPTLYSRLAEFLDICHQHGVSTFLVTNGSLPKVIENLDTLPTQL
YVSVDAPNKEIFDRICKPKFDQSAFEKLEQTLELLPSLDTRTVCRHTLIKGESLGHWNDY
ARLDNIADPDFIEAKGYIYVGNSQSNHTIENMPSHDEIMEFSRNLAPLVGREVLSDRRES
RVALIGKEMIPVTLPTKTRDLPKDLGIAKPQKFSLPQL
>A0A2E8V4A8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGIQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKVLENLDTLPTQLYVSVDAP
NKEVFDNVCKPKWNSRAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDKHIEQFAALDN
RAEPDFIENKGYVFVGHSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GHKITPIPIPEPTMFFPEDLGIAPPVKHLPIIQ
>A4IHE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xenopus tropicalis|TrEMBL
MSTNAWDFAYTHLMFLWLNRFYIYSCAAIGITVWFCSHFITARKKQQNENVHNGSLPLKT
KTLKSYNSPSIKEQDVYVAGVKIFYGSQTGTAKGFAHMLDGEITLLGLPVEIINLKEYDP
DDNLIEEATSKNVCVFLVATYTDGQPPESAEWFCKWLEEASNDFRFGKTYLKGMRYAVFG
LGNSVYSTHYNTVGNNIDKWLWMLSASRVMTRAEGDCNVVKSKHGSIESDFEAWKAKFLS
RLKALISGEKKPCSGKCKKGKCKSKKKSSTDAVEEEAKHSEHEETEEEAFETTSDSEPEE
HGEPGSGLIDMEDLGKAMSIMKKTKREQDTNEEARNRGKSLQSDEAKEKEEPREMITPAL
QEALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILEEAILNHQNMIKQFKGVPGVKPERYEEGLVVKHC
ALSLVGEPIMYPEINKFLRLLHNQHISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVEELKAYADLVAVGRPDFI
EVKGVTYCGESSASNLTMANVPWHDEVVRFVEELADLLPDYEVACEHEHSNCMLIAHEKF
KIHGDWWTWIDYERFQELIRAFDESKGSQTFTAMDYVAKTPEWALFGSRERGFDPLDKRF
QRKNKTKDISGC
>A0A2K1K762|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Physcomitrium patens|TrEMBL
MPSTNSLVGETRDGDTAENLVAQTSALDIVKKGGVNGEAPTLYKQRSGNFIEDEGGIWGL
EGDAAKCGCSDEAKAVCTVAAKEGDQKCGGGDNVGGGNFIEDAGGLWGIGVNGSKCGCSD
IADAGDKRCGDGSDLAANASGGSCSRICGTCTDGSEKSQACSKSHEVALHQVHPATGVSP
FALSEDGVRGKIFFASESGTTKRLAERLLKKFNDKSLPVDLVDPASYEPEDLPKEKLVIV
VASTWEDGKAPKNAAFLAQWLEESSEDFRVGSGILRECRFCVFGVGSQAYGANFNAVARA
FDAHLASLGGLRMALRGEGDVDEGTVDQEFDDWSKALLEKLERADPRRLSHESAAEPLAT
NEAEESSKFDGYLSATQGSDEDSDEDSETFEDADESGNFSDGVVDLEDMGGQRGMSEPLE
ASQKRGVVRRQPPKKQPTPLAKVLKDGPKEMVTPVLRASLEKQGYKILGSHSGVKLCRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWRWQMDDPVD
IVNGALEQHTKMIKQMKGVPGVKPERLAEGMNPRHCALSLVGEPIMYPEINTLVNELHKR
RISTFLVTNAQFPERITNLEPITQLYVSVDAATKEKLKAIDRPLFSDFWERFIDSLKALE
DKGQRTVYRLTLVKGWNTEEVKAYAELLDLGQPDFIEIKGVTYCGSTATSSLTMENVPWH
EDVKAFAEAIAAERGGAEYELACEHSHSCCVLLAKTSKFKVNGKWHTWIDYEKFQDLVAS
GKPFGSEDYMAETPSWSVYGAVEGGFDPKETRVKKERRHGTADPGGCT
>A0A131ZVU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sarcoptes scabiei|TrEMBL
MDQFQSIELLHADQYDPEDELINDARLKTLLIILMPTYSQGEPPEEAEWFCKYISESSED
FRFPKNALIKLRFIILGVGDSNYGDDFCKCAFNLERCLKNLQANCLIPMTGIDVSSNESI
EDQFSRWFDNLSLIFQQSDRTVPPSRNSRSSISPEYSCSEKTDSSDFEELCSPPDQIVDL
EDLVEPIKVRSKDGESKSSTLINDMITPKIRKELSKQGYKLVGTHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGTKWQWNLDDPEMIFNDLQ
KQHYSMINEFKGVPGVLPERIDSARTIRHCALSLVGEPIMYPKINELIRLLHSRSISTFL
VTNAQFPDAIKNLEPVTQLYVSVDASSKISLKKIDRPLFHDFWERFLDSLRYLSLKNQRT
VYRLTLVKSWNSDEIDGYAELVMIGRPEFIEIKGVTFCGDSSDSKLTIKNSPRHCEVVGF
SQSLTIKINHLIRQNIIKHKGNEGFNSPDIENEFYAIASEHEHSNCVLLAKKKFYISGFW
YTWIDYDRFDSLIKEYYESKGKKTFSSKDYCAQTPRWANFGAKEQGFDPEQTKVKKERRH
YNQTM
>R1G0V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emiliania huxleyi|TrEMBL
MSLLRLDLLPAPLLAALSIFALTLVYVIFGAAPSPPEASAAASAADSSAAAAAGRPASGR
QPVVVFYGTLKGGSRRLAERLAAALREAGVAAETVSLIGYDTDGLTSLECAAFVIATYEG
GVPPPGCEAAVDSLASAAADFRGTDLDLRSLRFSVFGCGNSEYPRRDFNAAARRLDGSIR
RLGGVRVARSCWGDDIDNRLSEQFGEWSARAVPSLAAAARPRSGADAAAKRGAARDGSAG
AEQAAGGQDGRAVGLEDENGDEEDEGEGEEDGEEEDADQGGLSDSGGLVDVEDLGARMSK
RAAAAGGEGRKKMVSESLRKSLTKQGYKIVGSHSGVKLCRWTKAMLRGRGGCYKHTFYGI
ASYSCMEATPSLACANKCVFCWRHHDNPVGTSFRWEVDDPHELVEGFEREHLKMVKSLRG
AGRGWAGVDRGGARVGILPERLEDALRRVRHCALSLVGEPIIYPRINAFLAELHRRRIST
FMVTNAQFPKEMEQLVPCTQLYISIDAPTREQLKAVDRPLFSDFWERFNECARVHRQRTV
FRLTLVNGWNDSELDAYAELVRRGAPDLIEVKGVTYCGDSKASPLAHESTAPLLHCPFHH
EVRAYCERLAAAAGPGYTIASEHAHSNCVLIAADAFCRDGVWHTWIDYERFFDLYQDWQA
NGTEFTAAEYAAPTPSWAVYDPLATDGGFDPAERRVAGKQGAAKRAASGAAAS
>N4UZN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum orbiculare (strain 104-T / ATCC 96160 / CBS 514.97 / LARS 414 / MAFF 240422)|TrEMBL
MAFSLDQPGLMVMLNDFHDVWQQVRIPVILFTLFGLFVLRLYYHSTEKKGELKALPKVYN
REKPETEPKGLAVDEKQVVNEIVAVEKKELKPIPVAEPKPAKSSGPKRIKGGLVKRSSEE
LKNSEVAQPIRPLIFFSSITANTPKIAKEYAERLGKDLEKTATDTGCQFKTPEVLDLAEI
DFDDYFITPPKSEEPVELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGY
SVFGFGDREGWPTEEEGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYSERLAEWSEG
VVDVLGLVAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLVEEDAKPEKLKNSSKLEDVE
DLGRIMKSSQPDSAPAPAAPIAVDFTTYGKSTTATKKPTQAAKEMVPKNSPTYASLTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPL
HRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYARLVEKGLPCFVEIKGV
TYCGTSTASNAGLSMSNVPFYWEVSEFVTALEKRLNEMGLKYGIAAEHAHSCCVLLASDR
FYKDGKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGKGGFDPRDERVDRK
GRKIEA
>A0A8C4UDU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Falco tinnunculus|TrEMBL
MDTWNFYTCLVSLWLHRFYIYSVVGFGISIWIIIQFTTTKTKKKGEKSKGNSAASEGTEG
KLVNGCAALQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVTSLNLPVEVISMGDYDPDD
FLSEETTSRNICVFLVATYTDGQPTESAVWFCKWLEEAVNDFRFGKTYLKGLRYAVFGLG
NSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSQL
QALCRGEKKPCSGKCKKGKCKSPGKQSKENSDHEHGSSENENTEAEELFETSSEEEADAE
VAGGTNFVVDVEDLGNIVSHMRKAKGERELEEGGVETRLTQENPGKKEGGKREMITPALR
EVLTKQGYKLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCA
LSLVGEPIMYPEINRFVKLLHQYSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIE
VKGMTYCGESSASSLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFK
INGEWCTWINYERFQELVREHERSGGSKTFTAADYAARTPRWALFGSKERGFDPLDVRYQ
RKNKARDISGC
>A0A4Y7IA99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Papaver somniferum|TrEMBL
MTLSSSIPTRYALLALLSASTIYCIWKSRRLLQLKLSPQNPNPNLANTKGKIFFISQTGT
SKALANRLLDLLKLNGLDFDVINPKDYEPEDLPKETLVLIIASTWENGKPPSDGGFLANW
VAESAEDFRVGSLILSGCKFAVFGVGSRSYGENFNVVGRDFSQRFRALGASEILPLCEGD
VDEGDLDDVFDVWNTKLIGVLKGENLNENGGVNGDECGSESEYEDYSDEEEEEEETDIVD
LEDIAGKGPSRNSKAAATVKVVANGEKEMVTPVIRASLQKQGYKIIGSHSGVKICRWTKS
QLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDDPLEIV
NGALEQHTKMIKQMKGVPGVKSECLAEGLVPRHCALSLVGEPIMYPEINTLVDELHRRRI
STFLVTNAQFPEKIRSLKPITQLYVSVDAASKESMKAVDRPLFGDFWERFLDSLKALIDK
EQRTVYRLTLVKGWNAEEIDAYYDLFAIGKPDFVEIKGVTYCGSSATSKLTMENVPWHAD
VKAFSEALALKSGGLYEVACEHVHSCCVLLARTDKFKVDGQWFTWIDYEKFHDLVASGKP
FTSKDYMAVTPTWAVYGAEEGGFDPDQARFKKERRHKTK
>A0A088RI92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania panamensis|TrEMBL
MMIAFLFQLLVSVGLPLVALLLYNHLADSIHARGSVNVDDVNAFSQRVRAELEQLNVPPA
LPEAAPGQAAPPPAPMRSSPAVTAPPPPEAAEILIAYATQSQNSLALAHKLFSLITAQLH
TAPPSTTDDAVCPLVRVMEMREEEDSSASVAAASAAGGRVSRTNVCRVDTLLEQSQYALI
IFIASTYTNGVAPPRSQAFEALLKDSFEDHRIPRNTLARKRFAVFGLGDIAYGEERFNAF
AKNLHEWCRGLGAPPFVVPPVYTTEAKTQSLFRIFSTALLKWVSRATFHRDGTVTVKKKS
EMGTTGPAAASATGMLSHKAGGITAAPAGETCGSEGASCACQQSTQQQQQQRQPCGNSTG
PDGDDNCGCCKTDSIANCVAASKRDDDDEADDDDEEEEVNGENDGMDDVEDLVWDGTEDT
DFDINKDPSELPELLYPKLRQNLEKQGYRLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYN
INSSQCMEMTPSLACANKCVFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMR
GVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFCELLHQHHISSFMVTNAQFPEQLR
DLKPVVQLYLSIDAPTPEELKRIDRPLFEDYWERCLSCVKELAKKQQRTVFRLTLVNQYN
TENVKAYADLVEMGQPDFIEVKGVTYCGTSTSSTLTMKDNVPRHDEVISFCKALCTEMAS
RHPHYSTLQMNTEEKGGDDGDDDEVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFEG
HWHTWIDYERFYHLVESGRTDFTSLDYAAVTPAWATYNSKEKGFDPEQTRVVRKNARPTV
VTASC
>X0MY84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. vasinfectum 25433|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A671Q912|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MVDPISPLLYKSVKNQELSPETEKVLHVSGVKVLYGSQTGTAKGFAKELAGGISAQGIQC
EVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASMDFRYGKTF
LKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQAD
FQAWETKFLKRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSEEELME
SSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNGVRKSES
EEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIRQFRGVPGVHP
ERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQ
LYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAY
ADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHE
HSNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGA
RERGFDPSDTRFQRKNKTKDISGC
>A0A671Q0K6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MVDPISPLLYKSVKNQELSPETEKVLHVSGVKVLYGSQTGTAKGFAKELAGGISAQGIQC
EVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASMDFRYGKTF
LKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQAD
FQAWETKFLKRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSEEELME
SSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKAKVKTKPFCLCINETNVAFLLLVNAER
ERRLLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIRQFRGVPGVHPE
RFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQL
YVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYA
DLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEH
SNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGAR
ERGFDPSDTRFQRKNKTKDISGC
>A0A0L8VFR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces boulardii|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A2H9PPS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG_4_10_14_0_2_um_filter_33_10|TrEMBL
MSPELKALLEKQHYCFSGEHSAVKICTWTKKSLLDENVCYKEKFYGIRAHLCCQMTPSVG
FCTNQCIHCWREMEYTAGVKMNGILDEPEEIIKKSILCQRKLLNGFFGNEKANRKKLNQA
QEPMHFAISLTGEPTIYPKLSELISELHKLGKTTFLVTNGQFPDIIKSLKELPTQLYVSV
SATNEQDFKKFNKSCFKDGWKRLNKTLELMPELKTRTVIRITLIKGINMKDEKAYAGLIK
KAGPMFVELKAYMFVGSSRKRLLESNMPLHEEVKEFAEKVAELSGYKIIDEKKESRVVLL
AKKDYKDRIMRFD
>C5LCT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus marinus (strain ATCC 50983 / TXsc)|TrEMBL
MLAAGGFYHALLSKHYTGPQRTVKVVYSSRTGTSMKAARRLKAALESSTTRVILLPIDQY
AYEELCEESYLVLLLSTDSEGSPLPNAKSFTEQLKDAVYDFRVDKNLLEKCRVAVIGFGS
EEYPAKYYCKVAKNCDDWLAKLGAQRICPLLCVNDAKEVDKQVGRCIDLITKAYSRMDKA
SSEAQTADLEDEVGSVASEESTSDTDDDVEDASEGCGSNRKEMVTKKHRAALTREGYRLV
GSHSAVKLCRWTKHQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPVG
RSWTWAQDPPEEIVEGWLGNHSGLIKQLKGVPGVTPERFEEAKRVRHCALSLVGEPIIYP
QINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAKEMKAIDRPLFEDF
WDRFIDSLTALKHKKQRTVYRMTLVKGYNISAASEYAELLHLGHPHFLEIKAVTFCGKGD
GSAQMTMENVPWFDEVVEFAEAMLDSSDWVKERYEIACTHRHSCTVLIAQKSFKVDGVWH
TWINYDKFTELALEYSKTGKPFSVEDYWAPTPAWAVYGAEEEGFDPEMKRHYRNGKTAEL
GKQIRARQLREEREKAAECGFGSLAAQGRGLDRSSVDSYFVVISTVVILKVAVEELARVS
NSIVVQ
>A0A842Y395|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MNSFDIFKKQGYHIVGSHSAVKPCLWSGRSIKLQGSCYKSKFYGIDSHRCIQMTPFLGCN
QACLHCWRPVEHPVEVPRVWDNPEEIVEGCIHAQRRLMSGYGGLDKADPEKWKESLAPKH
AAISLAGEPTLYPYLPDLVDEFRDHGLTTFVVTNGTNPEVIENIKPTQLYMSLDAPDRET
YMKCCNPNHAKQWEKILHSLAVLHDHPARTAIRITLAKGKNFVNTTGYARLIELANPDFV
EIKSYMHLGYSRKRLDRSAMPLHQEILQFSNELALELDYKLLDDVELSRVALLSKNEKIQ
KI
>A0A2G4J1M1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGEIVDNNNENLIQIKPAIAAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKF
YGILTHRCMEFSPAGMHCENRCVYCWRPMEFYDAMKMEPEQVAEPEQILRKLMNERKKLI
DGFYGDSRNDNQRLDESLLPTHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFIKINKPKYDDSWERWNRTLDMLKNLDTRTV
LRITLIRDYNDQKEMIPAFADMFRKASPHFIEIKSYMHIGRSTNRLEHKNMLEMYEVKKF
SEEIAKQSKIFSVMDESLVSRISILQNNVRFIDRYISTYANTN
>A0A842NBF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHSCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEEIMTKLMAERKKLIM
GHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQKLEDEDALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLGTRTVL
RITLIRGYNDDEGMIPAFASLLQKSNVHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRSFG
DKLIQENNAFTVMDESEISRIVILQNKKRFIDRFIPAYC
>A0A3M9LTE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp. RSK|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPQKWDSPVEIMGSSIECQRNLISGFGGSVPRELWQQAN
EPTHVAISLSGEPTLYPYLDGLIEEFRSRGVSTFVVTNGTVVEMVKRINPSQLYMSLDAP
DRQTYMEVCSPKDPGLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPGHEEVLDFANQLGCELGYEVGDQVEISRVVMLCRD
ESVVASKLPV
>A0A662QKX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MPAGALADRASRLEVREIERLRRAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGIRS
HRCLQMTPSLQYCNLMCIFCWRHHTINRLEAYAGDWDRPEEVLDGLIEEQRQLLSGFKGN
PKVDRRLFEEAMEPKHMAISLDGEPTLYPYLGDLIRLARSRGMTTFLVTNGTNPSALRKL
IEEDAEPTSLYISFYGPDEETHRRICRPLIPDSWSRLMESMKVMREFEKSRKVIRLIMIK
GYTMHDPEKYAEMIRVAEPDFVECKGYMHVGESQKRLRKENMPSLDEIRVFAEKLSKALG
YEYLAEDYPSRVALLANPDSKHYDDVRERAAKLSGG
>A0A2B7Y8B5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Polytolypa hystricis UAMH7299|TrEMBL
MGGSSADMVSGGLLSLWHSYRGYIIIAATVGILIIRLFVNSAPKSTPSASSPPPAKSVPL
KAVESTKSPSLEVSREAATAPTTQSRPSSAERQKKPAQAANGPKRVRGTRPTKNGQKGHS
DKIEAGQKIAVQPLVFFSSLTSTTESRAKFLSERLCKQSESSIVDGAPAFLPPQVHDLSY
IDFEDYFVTVPKVPEQSPNTKYMYFILIPTYNIDSIIDNFLGHLDETHNDFRIDTAPLSG
LAGFSVFGFGDKEGWPTEEEGFCSQAREVDKWMAKLTGRKRAYPLGLADVKADVEGPLIE
WCDGLRDALVDLGTTGGLGEGVPGSGNAVESDEEDIDDNNPSNGDAQLVDLEDIKFGATE
ESSAGREALPVDFTTYSKSSPAPQSEPVKEMVPKTSPTYASLTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPP
ELIFDGAKEGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINKFLSLLH
REHISSFLVCNAQHPDQLAALDRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDI
IREKRFLQRTVYRLTLVKGFNVDDEVNGYADLVEQGLPCLIEVKGVTYCGTSTSAGAGLT
MQNVPFYEEVVSFVVALDAELKRRDLGYGIAAEHAHSCCILLASNRFLVDGRWHTRIDYN
KFFSLLEKEQRDGTTFRPEDYMRETEEWAWWGNGGFDPNDERVYRKGKKKGTVIPAKPLT
NKEAVVEI
>A9A4X1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus maritimus (strain SCM1)|TrEMBL
MSCSGEVVEEEQLIQIKPAISEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLING
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQEP
DMIQKLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLGMLKHLNTRTVLR
ITLIRNYNDQKSMIPAFAKMFKEASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKRFSE
QIAKQSQIFSVMDESFVSRISILQNNERFIDRWIPAYVNTN
>A0A097QSU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus eurythermalis|TrEMBL
MAIVVKSDPNMPDEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWDRIKETLRLMRDAQTRTVIRLTLVKGE
NMHNPEGYAELIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPSGRGLNGRFIGD
>A0A3A5W593|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDEVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDAHIKEFAALDN
RADPDFIENKGYVFVGHSRENLAMENMPSHDDIMEFSRKIAPLTNREVLSDSRPSRVALV
GTEITPIPIPEPTMFFPEDLGIAPPVKHLPIIS
>A0A8J8WCU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium sp. RFL-2021a|TrEMBL
MHGLLAIWHTWRVPLLVAFAVLLVSLRLYRRGKSRSHTLTTTSIPTPPRIESHEKSISRV
PPVATSRQNYTNDKENSNTSQTGAVAKLAAGPKRVQGKRPAKTVTGRRAISEEQTHPLFI
QPVIFFASLTTTTERYANRLLEELRVVAQEYTKLAIPNGGLLLPQIHDISYIDFEDYFAS
APKPPSTAPGTRYLYCILIPTYNIDTVLNTLLAHLDEIHNDFRIDTAPLSQLAGYSVFGF
GDKEEWPTEEEGFCSQAKEVDRWMAKLTGRKRAYPLGMGDVKNDAEGSLRKWSEGLQETI
VDILRNGGLGEGVPGSGDAVESDEEDLEDMEYLDDESYAAKQKKMGGATMVDLEDIKMNG
QSGAPIPIDFTTAGPTILAQPQAKEMVPKTSPTYSALTKQGYTIVGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFN
GVKEGHYKKIKMLKGVPGVRAERFAEAMQIRHCALSLVGEPIFYPHINRFLDMLHQERIS
SFLVCNAQHPDQLEALNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKR
HIQRTVFRLTLVKGFNVEDEVMGYANLVEKALPGLIEIKGVTFCGTSTSAGAGLTMKNVP
FYEEVSAFVVALNNELQRRGLEYGIAAEHAHSCCVLLASERFRVNGKWHTRIDYDRFFEL
LEKEKADGTSFAPEDYMRETEEWALWGRGGFNPDDERVFRKGRDADSRARKAREILGAEM
VPEVV
>A0A835ZKI8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ovis aries|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNLQEKTTPKASQD
LMTNGYIFRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLDLPVAVINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGERKRCRGNCKKGKCESNQRSSEAVEPGSHAQEELHHGDAEEEEPFGSTSEEESD
AEDHQSQNSVIDVEDLGKMMDHVKKEKREKELQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKGERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGGEWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>W8P2U1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus nautili|TrEMBL
MAIVVKANPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQFYVSLTAPDIETYNRVNVPMIPDGWEKIKETLRLMRDAETRTVIRLTLVKGE
NMHSPEKYAELIKIANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDGRGRGLTGRFISD
>A0A7J2ZLS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MVISIETRKDLEKAGYRIVGNHSGIEICHWTKESLRSGRVCYKQKWYGIQSHRCLEMSPA
IIFCNHKCVFCWRKLKWTFLEEPKPDDPKDIVDGCIAARKALLTGFKSYVNIKKWEEAIN
PTNAAISLAGEPTLYPRISDLIEEFHKRGMTTFLVTNGTRPDRLKNLATEPTQLYISLCA
PDKESYFKVHNPLIPDGWEKLNESLELMKSFGCKTVIRMTLVKGLNMKEPEKYAKLILKA
EPNFIETKAFMHVGEAQKRLPRSAMPSVEDIKNFAERIANYTGYKFKDLDIASRVALLTR
K
>A0A6A5KT86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Decorospora gaudefroyi|TrEMBL
MLVVANSVIEILLIWHQHRLPILLSALVVATIARLAIYTRQRRAKTSASPVPSSPIEKKA
VELKPEWLPEYTTTLSPPQLNTDNHSEDDTNAVVLVARAKKGPKTVKGRKIQKKISTPAP
TFDHKTDKIQALVFFQSLSGTTERYAAQFTKVLGEWTAGCEQSSSFLEPQTHDISYIEHD
DYFISPPKAGVNIKYFYIILVPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGYSVF
GFGDKEGWPTEEEGFCSQAREVDKWMARLTARKRAYPLGMADVKTEAEERLQEWRIGVQE
ALIELAEGRGLGEGVLGSGDPAESDEDDVEDVEGGSGEDTRVDDVEDLGTMVTSSSAPIP
VDFTSYKKSTPKSKPTAAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRGR
GSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPELIFDGITA
AHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLEIMHKNRISTFLV
CNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQR
TVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPFYEE
VAAFVTQLEHELRARGLDYGIAAEHAHSCCILLADRTRFQREGRWATRIDFERFFDLYEG
KVRGSRVEDGNVVGWRPEDYVGQDTPEWALWGNGGFDPRDARVYRKGKGPRKDGEVEEKR
KRAALALEF
>A0A0J9TBV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax Mauritania I|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSNLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSTHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEILSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>A0A150ASL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Madurella mycetomatis|TrEMBL
MSPDVRDVMPSVMSEITDYAVELWHQRRIPIIMSVLFLLSLLRIYFHSTAKRQELLVLPK
LYEKASGRSVTTVARDEKTELKSRTKEDGLEGSSGFTSNGDGKNGRIKHAPRRIKGEAGR
KPRGGGVEAGTDARKIQLFIFYSSLTGSSEKITLTFAQALGDALGCSSEKEPGNAFLTPR
VLDLAEIDYDEYFITPPKTEDKQTDPFYLFVIPSYNIDSINDNFLEHLKETHHDFRIDTS
PLAPILGYSVFGFGGREGWPTEEEGFCFQAKEVDKWMAKLSGRKRAYPLGMGDWKRDGKE
RLAEWQDGLLDVLKQLEQTGSLGEGVPGSGDALESDDEGEAEDDREVLLEENSDPNITKG
RASGGLEDVEDIGRLMELSRLDGLSGKKPSAPLAIDFTSEGKPKARKTGTAVVKEMVPKN
SPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCS
NKCVFCWRHGTNPVGTTWRWVVDPPQLIFDGVRENHYKKIKMMRGVPGVRAERFAEAMRI
RHCALSLVGEPIFYPHINEFLGMLHGERISSFLVCNAQHPDQLAALQHVTQLYVSIDASN
RESLRRIDRPLHRDFWERFQRCLDILRERRFRQRTVFRLTLVKGFNVEDEAEGYADLVER
GLPCFVEVKGVTYCGTSTSSSAGLTMANVPFYQEVCDFVMALEGALRKRGLQYGIAAEHA
HSCCILLASERFKVGGKWHTLIDYDRFFQLLEEKGPDGDFTPEDYMGPPTPEWATWGNGG
FDPRDQRVDKKGRPIEAA
>A0A267F4K9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
SASKMSHWDLTVHISRALQNSSALSYSLLLAASVVGAWILFQRRGRQGHVISASSVKKAV
LSSSSQMSLRSPTTRKAMLPTTSCTSTANGSVDETFNKVRVFYASQLGRAKHFATLLRDE
LAGVLKQQKQQQQQSQCCNGGDGEACKSTTVSSSDSAGIELIDLANYDPEESPHKESPDT
LCYFLLPTYEGGSSPNTGAWFCKWLAEAAEDWRVERGHLSGLRFIVIGLGNSLYAENYNL
IAKRVDEQLTQLSGTRLRPPVLLDENVASATGHGGQEADFQAALQSQLLDPLVSKKKKSA
CCSEATGNSACCQGAEAASDVAEDHSDVDSDHLDEEDQDGLVDVEDIGGVLSSATRSNQK
QKLRQEATTRRAMVTPLVRKSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGI
ASHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWLEDPPDEILSGALDAHRRMIREFRG
VPGVMPERISEGMQPRHCALSLVGEPIMYPRINQLLHLLHTSGISSFLVTNAQFPEAMRQ
LPPVTQLYVSVDAATPDSLKRIDRPLFKDFWQRFIDCLRAMRDCGQRTVYRLTLVKAWNT
EKVQQYAKLVDLGCPDFIEVKGVTFCGDSKASQLTMGNVPWHKEVVQFSQALADSLANQY
DIACEHEHSNCVLLANKRKFLVNNRWHTWIDYDRFEQLYGRFVETGQRFNAADYMAETPE
WAVYGSAEQGFDPNETRFRRRAAAAAAAASGDY
>A0A7K8Q093|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cochlearius cochlearius|TrEMBL
LDVSMDTWNFAYTCLVSLWLHRFYVYSAIAFGISIWIVIQFTTTKTKKKVTEHGEKSNGN
PASSEETEDKLVNGYATLQAKEVYVAGVKVFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
NMGDYDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKAYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRILTRAEGDCNVAQSKHGSIEADFEA
WKAKFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDREHGASEYENAEAEELFET
SSEEEADAEEAGGTNSVVDVEDLGNIMSHMKKAKSEVATRSSGSHPVLDKGVPGVAFKID
GLIYFLFSGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKH
CALSLVGEPIMYPEINRFVRLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDF
IEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLIAHKK
VRL
>A0A3N5V0I0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSDEYISHTDTPNLIQISPLTKAKLKKAKYGVYNHSAVELCHWTKKSFSNEGTCYKHK
FYGISTHRCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPADLVDEPDMIINNLLEERRRL
IVGHYGNIKTDKIKLDESLFPQHYAISLSGEPTMYPKLPSLIKYLKTLKNTKSVFLVTNG
QEPEMLQRLIDEDALPTQLYLSTNASNKKMFMMVNRPRYRDAWDRWQESLKLLSEMNTRI
VLRMTVIRNFNDSTNYVDEFADMMKIGNPHFIEIKSYMHIGMSTQRLESSDMLEMDEIRN
YSHLLCKSLDRFSIMDESEISRIVVLQNLERFTERWIEGYEKPLIQ
>A0A5N7BMR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus bertholletiae|TrEMBL
MAGISLTEGFVALWHSYRLPILIALASVAIILQAYRRFQPKSKAVTASSIPPSPRSQTPE
KFEEIRTGEREKPTAAEKIVLKPATGNNPAPKVTPGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTATTERYAQLLLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLSHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAEAALKEWSRGLQ
GILVDILDNGGLGEGVPGSGDPLESDEEDLDDEEGDGKRRKRRNGQDVVDLEDIKMGSDG
QAGSGPVPVDFTTAGKSAAPNQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHNEH
ISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVVGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVYKKGKKKALQAATE
>A0A8I6TBF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cimex lectularius|TrEMBL
MILPVGLFFLSGTVVCSLAAVFLTVLVLRFRFKRDQKRDEPDAKVSVRKQTFVGDRSLAK
KLKTPKRRETGRFGELEISKIMVYYATEYGKTKTLAEKITCYEFDNKVDVTVLDISTVEP
EESLNRDSNGTNTMTLFLFPTVADGKPPVSGIWFCKWLNEAANDFRVEKAAYSHLQYAVF
GLGNSQYKNDFNLVAKNIDSDLLNLGANRVLPVRLGDEDTSESSYGGIENDFNDWLKRVN
NALKHTNISIEHPVENGINFESSDEEEANVVDVEDLVKPKSKITTDQKEMITAPLRQVLT
KQGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHSNPVGTEWKWKMDNAEDILKGALENHYNMIKEFRGVPGVIPERYKEGLKAKHCALSLV
GEPIMYPEICKFVKLLHSKEISTFLVTNAQFPDAIKALDPVTQLYVSVDASTKESLKKID
RPLFKDFWERFIESLKALSSKGQRTVYRLTLVKAWNFDEMKDYASLVSLGNPDFIEIKGV
TYCGGGEAGKPNTLTMANIPWHSEVTSFVKQLVSLLPDYEIASEHEHSNCLLIAHKKFKL
NGEWYTWIDYDKFHELIQKFYETDGSKTFTALDYLKKTPPWAVFGCAEQGFDPVETRWHR
KNNTKDVSGC
>A0A7J3S9Q6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriaceae archaeon|TrEMBL
MFISKSQKLKRLERMGYKFVGKYAHTAVKTCLWTRKSILDEGVCYKQKFYGIKSHRCLQM
SPSIFSCQQKCLFCWRDLRSTKTAWEGGCDEPADIIEDCINAQRSLLCGFFGNEKANKEK
LIEAQEPNNAAISLAGEPLLYPMIDELIKEFHKRKFTTFLVTNGIDYKTLENLSEEPTQL
YISLDAPSKNIHNELCQPQIKNAWECLNKSLELFPSFNCRKVLRITAVNGKNMTNPSGYA
SLIKKAQPDFVEVKAYMYLGYSRQRLEIENMPLFFEVYEFADKIAKTANMNIIDESKESR
VVLLS
>A0A1V4ZIW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregula sp. PtaU1.Bin006|TrEMBL
MPSKPCEPLQKQGYQFFSKTSTAALKPCMWCKRALQGGDMCYKHQFYGIASHRCVQMTPT
LRCNQRCLFCWRSFEHEPAEEEECPPETILTGIHRLQKKALAGYNAVLDNTVTDERWQEA
LDPKHVAISLSGEPTLYSRLPELIDLFNSRGYTTFLVSNGTNPGMLERCKPFQMYVSLDA
PDRETYYKVCRPLGDTWDDVQESLRLPGSQRSAIRITLVKGLNDFAPERYAAILQDSGAR
FVEIKGYMYLGYSRNRLARENMPEHAEVRAFAEKVAAACDYRYKDENELSRVVVLERIS
>A0A2H0ZP50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida auris|TrEMBL
MTSGTPILAICSLIYWLTGGRITFVAAAWCALWFHKGKLQPFSAASSAPPITKPVKSSRI
MEVDFTNSFTPDSKTEFPKAVPLKKKTRRTREPKIFKAAAKSGKPSKGVSHLTTNSVQLK
KCPIYIFYTTLTGSSLRVAKALHQKMANIDGIEVPPRLLSLDDDVDDLEEYFLRTPKSEN
PPVYLLVLPSYETDSPIDYFLEHLTDTYQDFRVDKYPLRTLAGFAVLGLGDSESWPGSQF
CYQAKSADKWLGKLGARRLFPVGEVCMKHEGEPKSQDWINGFSELMVDDQPFFFEDDPAA
FDSDAGSDEEEAQAEDENVVDVEDMGAIIRASKNKDAAVAEPKQMVAQDSPTYKSLTKQG
YTIVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGT
NPVAKSNWRWEVDPPEKVLEGALDGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGE
PIFYPHINEFVGMLHSRHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKNDLKKVDRP
LNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGA
TFCGSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTK
FKINNVWHTHIDYPKFFELLESGADFCDLDYIQKTPDWAIWGAEEGGFNPADTRYDRKAE
KLKKKQARDETAAKALQAKKSESIKASSEFSEHTRELFVS
>H2PLZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pongo abelii|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGRNLQEKSVPKAAQD
LMTNGYVSLQEKDVFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEAAIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQRGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGKDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWRRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>L7LUV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhipicephalus pulchellus|TrEMBL
MCTADFPHGARXVMFQSITRRFVTYLLCALLIFHTVHAKGNVNEKSRSDWYPSSYTTTLC
GGVLAVLFFVIAREKLNLSKIKTQDPFKQRQRKRNGKSVKVLYGTQTGNAKILSEKLTAE
LDALDYDVEMVNLKHVEPEECLLGQVKAKGLCIFIVSTYVDGSPPDEATWFYDWLKDTYA
DFRVHKYYLQGLNYAIYGLGDSAYGDNYNKVAKDMDFWLSKLHATPVVPLCLNDESHDEG
KYGTGKFPGWKDDVLAYLEGRPSITTQPREAQVAPEDVAYESSSDEGEPELIDLEDLGNV
RSTAKSKESKTVKNGEARPDMLTPLLRQSLGKQGYHLIGSHSGVKLCRWTKAMLRGRGGC
YKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWKWNMDSPEMIVENALKNHY
KMIKEFKGVPGVLRERLEEGLRARHCALSLVGEPIMYPEIGKLVRLLHDQGISTFLVTNA
QFPDALRQLGPVTQLYVSVDASSREALKRIDRPLFPDFWQRFQDSLSTLADKGQRTVYRL
TLVKEWNMDEMQGYANLVALGKPDFIEVKGVTYCGDSKGARLTMSNVPWHDEVLSFVKQL
VALLPDYSIASEHEHSNCALIAHNKFRVNGQWNTWIDYERFHELVQRFYQTGETFTSLDY
AAPLPHWAVFGAKERGFDPSDTRMFRKSKKDISGC
>A0A133VJH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA382A20|TrEMBL
MVLSPKEKENLENGGYRLVGSNEHSAVEICRWTKKSLLDEEICYKQKFYEDIHGIKSHRC
LQMTPSLPFCDNKCVFCWRDSQINSPEWEGEVDDPSEILDEAIQAQRELLSGFKGNPDAN
KDKWREAQNPKLSAISLDGEPTLYPKIGALIEECRRRDIVPFLVTNGQHPKVLEKITEPA
QLYISTVAPEKQTYLEACKPLVSHPWENLNQSLELIPSFDCVTVLRLTLVKDLNLKDPSG
YAKLIDKAEPDFVEPKGYVAVGHSRSRLGPSYMPTHFEIKKFSKRLAGLTGYTITGEFEP
SRVVLLSS
>A0A0A0AQV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Charadrius vociferus|TrEMBL
LDVSMDAWNFFFTCLVSLWLHRLYIYSVVGFGISIWIVVQFFNTKTKKKGEKSDVKPAAS
EGAENKLVNGYATLQAREVYVAGVKIFYGSQTGTAKKFATGLAEAVISLNLPVEVISMGD
YDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGRTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDHEHGASEHENTEAEELFETSSEE
DADAEGAGGTNAVVDVEDLGNIMSYMKKAKRERELEEEAVGTSLTRENTGRKEEGEKREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLI
AHKKVRLPG
>L0ICA5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halovivax ruber (strain DSM 18193 / JCM 13892 / XH-70)|TrEMBL
MSNADAAGSGGEADTDTGDGGPKQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIFY
GIESHRCIQMTPVVRCNERCVFCWRDHQGHAYELDDVEWDDPEAVVDASLTLQRKLLSGF
GGNDEVPREAFDEAMEPRHVAISLDGEPSLYPYLPELIDAFHERDITTFLVSNGTRPEVL
AECDPTQLYVSVDAPERHTFDQVVRAMEDDAWETLIETLDVLAEKDETRTVLRTTLLQGE
NMHSPDWYAGLFQRADPDFVELKAYMHVGHSQGRLDRSTMPDHEDVVDFAEQIGEHMPDH
PVLKEVPASRVALLARNEDTWVPKLQKDSAFWARDPIVGD
>A0A7C8MA42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Massariosphaeria phaeospora|TrEMBL
MALLLGQLPTELLLIWHTHRIPILLSAVSLAAVLRLTVYLRSRRERISITLVPSSPIEKI
AVELKPEWLPENTTFVPSALNTDNHADSPVAVARITKAKRAPKTVKGKKVQSKRPTTAPD
FDHTTDKIQPLIFFQSLSGTTERYASLFAKTFTAWSSSDISPGSILEPQTHDLSYIEYDD
YFINPPKAEPNVKHFYLILVPTYNIDTVLDTFLENLRETHNDFRIDTAPLSALLGYSVFG
FGDKEGWPSEEEGFCSQARDMDKWIARLTGRKRAYPLGMGDVKDDAEARFEEWRLGVQEA
LVEIAEGRGLGEGVPGSGDPAESDEEDIDVAEDSDPELATGKPRKAKSSARVDDVEELGS
MVETSTTDMPDPIDFTTYKAKPALAPAPAPKEMVPVTSPTYAALTKQGYSIIGSHSGVKI
CRWTKSALRGRGSCYKYSFYGIHSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITD
APDVIFDGITEAHYKKIKMLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLEM
MHKNRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACL
DILRNRRYEQRTVFRLTLVKGFNMAEEVKGYADLVERALPGFVEVKGVTYCGTSAAGTAG
LTMQNVPFYEEVAEFVTALEKELSARGLTYGIGAEHAHSCCILLADSTRFQRDGKWATRI
DFERFFDLYEGKAQGTRMEVRDDGVAGVVGWRPEDYVGEETPEWALWGNGGFDPRDQRVW
RKGKGPKVTSDKESEGGLGAKKAVLEI
>M9U6H0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus LAL14/1|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A369H6X3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps camponoti-saundersi|TrEMBL
MPRARKHALGDVDLTQGDSARAKRPALAEATSVSAELPSQAGTQELDPIDLTQDPEPLTE
LYGQFDGKIVGVRYYNGYASPGETVLCCREPENEYDSNAIRVDNVLHQQIGHLPRKVVEK
IAPLMDTGDITLEAQLSGEKGMFDCPVLLSFFGPSDPIERARVEQELKATKLVKATQLKQ
TKKAAEALRAATGLKAGAATYGIGTDAADLAQAKVSLEELIKISDATEFSREGDAIKTLA
IDEAYLAAMPRAEQPPQLASTLLPYQLQGLAWMTSKEHPVAPQKDADRPVQLWVQDKKGT
YCNLASGFVSKHVPELCSGGILADDMGLGKTLQIISLILVGGPGPTLIIAPVSVMSNWKQ
QIARHVKPDQAPSVLIYHGDKKTTVKELMKYDVVIASYGRLAREIDKDNRTLLDKSAKWR
RVVLDEGHTIRNARTKVALAACELQAVSRWVLTGTPIINSVKDLHSLVKFLHLTGGIEQA
EIFNTIVTRQLAAGERGGEAILQALIQDLCLRRRKDMKFVDLKLPEKREFLHRITFHPSE
KVKYDALLSEARGALEEYQKRSAAGQKGRFQNVLERLLRLRQTCNHWTLCRERIDDLMKL
LEDEKVVVLNDKNRALLQEALRLFVESQDDCAICYEAPTVPVITNCKHVFCRGCITKAIQ
IQHKCPMCRNSLDEDCLLEPAVEGASDDNFDIDTQSSKTESLLKIVQATLQKPNSKVVIF
SQWTSFLNIVQNQLVQAGLKFCRIDGGMKAEKRDMAIEALDNDEDTRIMLASLAVCSVGL
NLVAADTVILSDSWWAPAIEDQAVDRVHRLGQTRETTVWRLVMENSVEERVLTIQSEKRE
LVEAVDLWHAHRTSLILCAVAVLVAIRLFLRDNKDVLVALPGIVNRDGEARRPEKTSSRG
PRRIKGGVVRKAAQKREQPVVPQVMAPIKLMVFFSSVTDTTSKLARDYRNHLAAATEKLA
LETGRPFLTPEMHDLAEIDLDDFFVAPPTSPAEASLFYLFLLPSYNVDSINDTLLQHLRE
THHDFRIDTEPLASLLGYSVFGYGDREGWPDEARGFCFQAIELDKCMSKLTGRKRAYPVG
MGDIKGDYVERFAEWATGVRDVVAHVARTGHLGLGVRGSGDAAESDEDEDEETSGQAEQL
GDVEDLGRVLPTNKTKPPLAVDFTTYGQQVKEMVPRDSPTYAALTKQGYSIVGSHSGVKI
CRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVD
PPDLILRGVKEGHYGKIRMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPHINEFLAL
LHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCL
DILREKRFRHRTVFRLTLVKGFNVDDEVEGYARLVERGLPCFVEIKGVTYCGTSTSANAG
ISMSNVPFYWEVCDFVRALDKRLAQLGLAYGIAAEHAHSCCVLLANERFRVDGVWRTHID
YDRFFHLLEERGPDGDWTPEDYMGAPTPEWALWGNGGFDPRDERVDRKGRKMEVAVVRER
PSSEIQ
>A0A2H9QU31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon CG_4_9_14_3_um_filter_38_12|TrEMBL
MNPNLRKILEKQHYKIVGSHSGVKACHWLKEKLIHNRCCYKEKFYGIKSHRCLQLTPTIN
QCTQNCLYCWRYQDFTEQELESFDEPEFVLEKSIDAQRLLISGFKGDERCDKKMFEEASN
PNQVAISLSGEPTIYPKLAEFIEVCHKKNMTTFVVSNGTQPEMIENLKPTQLYITVAAPN
KEIYEKLCAPMIKNSWEKINESLDILSSLNTRTVVRHTLVDKWNIGLENSGEGSSPSRQI
SSKFVDEYAELDMKAEPDFIECKAYMFVGYSRQRMNLENMPSHEKIKGFAEKLSDLTGYE
VAGEKKDSRVVVLAKDKRKMKI
>A0A843BLZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVIDQEEQLIQIKPAISEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLDMLKHLNTRTVL
RITLIRNYNDQENMIPTFAKMFKDASPHFVEIKSYMHIGRSTNRLEHSNMLEMDEVKKFS
EQVAKQSQIFSIMDESFVSRISILQNNERFIDRWIPSYVNTN
>A0A8C3EX70|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corvus moneduloides|TrEMBL
MDTWSYFHTCLVSIWLHRFYIYSAIAFGISLWIVVQFTTTRTKRKGEKSHGNPASSEGTA
DKLGNGCALPQPQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGRQSKESSDHEHGTSEHENTEAEELFETSSEEEAGG
TDSVVDVEDLGNIMGHMKKAKRERELEEGAAGTGRKEEAERREMITPALREALTKQGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALSLVGEPIMY
PQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTQESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLITLGKPDFIEVKFQVDGEWR
TWIDYGRFQELVREHEQSGGSRTFSAAEYTARTPPWALFGARELGFDPLDVRFQRKNKAR
DISGC
>A0A8H4YD39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sp. NRRL 66182|TrEMBL
MDWANYSSPSRLDSFVDELVDVWHVHRTPILLTIFTVLIAVRIYFHINGQKAEIVAFKKA
YQEPAKPSVIVEAKTPAVETIEEKKNVKSQGPRRIKGGLTRKPSKNKEDEKAVARPITPI
IFFSSITTKTHKIAQAYAEELGAKLEQLSKQSGRQFLKPEIRDLTEIDFDDYFIAPSKSH
GDVDLFYLFLVPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDKENWPT
EEEGFCFQAKEVDRWMAKLTARKRAYPVGMGDMKTDHEERLQEWAKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDIAEDEDDGEVVFEEDDAKKKTKGGRDLDDVEDLGRMIRKDDG
STTQKVPLAVDFTTYGSSTKKSVPQGPKEMVAKESPTYAALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRRIDRPLHRDFWERFQRCLDIL
REKRFRHRTVFRLTLVKGFNVEEEAEGYARLVERGLPCFVEIKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYEK
FFDLLEERGPEGDWTPEDYMGAATPEWATWGNGGFDPRDDRVDRKGRKIEAS
>A0A2Z2HI38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosomarinus catalina|TrEMBL
MSCSGEVVENDQENLIQIKPAIAAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHQF
YGILTHRCMEFSPAGMYCENRCVYCWRPMEFYDAMKMEPEQVAEPEQILRKLMGERKKLI
DGFYGDSRNDNQRLDESLLPTHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFIKINKPKYDDSWERWNRTLDMLKDLDTRTV
LRITLIRNYNDQKEMIPAFANMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMPEVKKF
SEEIAKQSKIFSIMDESLVSRISILQNNERFIDRYISAYANTN
>A0A2K5NXI5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cercocebus atys|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKTQDRNLQEKSVPKAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASYFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A445H2W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glycine soja|TrEMBL
MSISISLSSVPARLTLLAVFSATTFYCLYKYHRLRHLKLFLNPNPNPNPKIIFVSETGTS
KTLARRLHGLLASNDVAFDLVDAQHYEPEDLPKETLIILVASTWLDGAPSAASRFFATWL
ADAAADFRAGSLLLSRCRFAVFGVGSRAYGDSFNAVARGLAKHLRALGAAEVVPLFEGDV
DGGDVDAVFDRWCEKVVAVLKSGSVVESCDNDGAEESGVVSSSEDESDVDSSEIVDLEDI
AGKAPSWRKAVANGEESNEKLNGRREMVTPVIRANLEKQGYKIIGSHSGVKLCRWTKAQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIEIVNS
AIDLHTNMIKQMKGVPGVTLERLSEGLSPRHCALSLVGEPIMYPGINALVDELHKRRIST
FLVTNAQFPEKIKSLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKEKHQ
RTVYRLTLVKGWNTADIDAYSKLFSLGEPDFVEIKGVTYCGSSTTSKLTMDNVPWHADVK
AFSEALALKSQGEYEVACEHAHSCCVLLAKTNKFKIDGQWYTWIDYEKFHDLVASGRSFD
SRDYMAATPSWSVYGSEEGGFDPGQLRYRKERHHKSTRNQAG
>A0A5F5XZC7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Felis catus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDESVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAREKELQEEKSTLVRNAVKGEASERRAMITPA
LREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKH
CALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKD
SLKKIDRPLFKDFWQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDF
IEVKGVTYCGESSASSLTMANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTR
FKIDGEWWTWIDYNRFQELVQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTR
YQRKNKSKDISGC
>F1QPL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Danio rerio|TrEMBL
MERVHEMLFLSVLSGLVCSAVGAEMSGVLNDVRDYTEGYLQVLWQNRLYVYSTAAVLIGV
WFTVNMLFKKKKMVHPVSPPASKSVKKQEPASGAKKVIHVSGVKVFYGSQTGTAKGFAKE
LAEDVIAQGIQCEVIDMKDFDPEDRLAEECTSKIICVFLVATYTDGQPTESAEWFCKWLQ
EASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKSIDKWLWMLSAARIMTRGEGDCN
VVKSRHGSVQADFQAWKGKFLNRLQALAKGEKKACSGNCKKASCKNKKKHKEEAEDNHSL
AEKNNSEEELMESSSDEESSSEDEKSHGSVIDMEDLGNVMNHMKKAKQRMEEDEEDSQRV
KQNGERKSECEEERREMITPALRDSLTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAMENHRNMIR
QFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLKLLHQQNISSFLVTNAQFPE
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVK
AWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLL
PDYEIACEHEHSNCLLLANHKFKVDGEWWTWIDYERFQELIQQYEESGGTKNFSAMDYMA
KTPSWAVFGAGERGFDPTDTRFQRKNKTKDISGC
>A0A830HFA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pycnococcus provasolii|TrEMBL
MLAYLLAVAKALVFLAWHTGGALLLAYAYNLVALLVARANERKRGVDDGRQTAPLAAKRL
AIITHGKNTSASVSKRIAVLARSTGAWAHVEVVDAAGWEPETLLTRTFTHAVVVIATHQD
DNGEPCPPAPAAFLCQWLDEASCDERVGGAALSHLRFAVYGCGDSAYGTERFNATARRVD
ACARKLGATMACSPGLSDASGGPGAAPEEYVQRWWSRACMPGMLFRTEMPAPELSSASSA
TTTRETAMTADGGDDDGVEDDGKDDDVSGGNGTCGDDGLEDIEDLARSKSVPGEPLEMVP
VGSKIRANLTKQGYHVIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIASHQCMEATPSLA
CANKCTFCWRHHTNPVGTHWRWKEDDFLTIVDGAITEHCRMIKAYRGTPGVTPEKVAEGM
RPRHCALSLVGEPIMYPHINELVAELHRRHISSFLVTNGQFPDAIANLRDTVTQLYVSVD
ASNQVDLKRIDRPLFRDAWDRLKLSLSLLKEKRQRTVYRLTIVAGFNADDIEGYARLVRL
GMPDLIEVKGVTYCGDSGGGEDSLSMKNVPYHADVRAFVEELCRLLNADHIDGNVPAYGL
ACEHVHSCCCLMARKDLYEVSEGRWRTWIDYDKFHSLVASGEPFEAVDYAAETPSWSTWG
APEEGFDPSMERVRKVRNHHPNPPDRHQPPLVEGQ
>A0A2S4VUQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia striiformis|TrEMBL
MLHVVVLLVREYSKSSLFVCCSKTIEDPDTLFITILDDEETAEQLSTLLLTESEHLNSSI
DTLDNLDLDSLINQTPIDTVNQLIIFLLPSYNVESPVDSVLSQFRDALYDFRLDKNSLAG
LSFFVIGIGHSDYQNEFCKQAVELDSIIANLGARRIINIKKIDVSVDPEKDLSDYFQTVI
RTTLSPSLSSFAQLPPLSSSSEDDDNDEDENSDDEFKDYTSSKPLTKAEKARQKSSTKKK
KSSAGTTKEGTMDIEDLGTGIPQIEDLDIKDQDDEIIKKDMISPMTRKSLTKQGYAIVGS
HSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLACANKCTFCWRAHTNPVGTS
WRWKTDSAEYIIEESLKEHDRLIKQLSGMPGVRADRFTEARTPRHAALSLVGEPVMFPHI
KKYISLLTEKRISTFLVTNAQFPESLKDLPPVTQLYLSIDAGTKESLKSIDRPLHRDFWE
RFLESIDIVHQKKNRTVFRLTIVKGENENQIKEYADLVRRGQPDFIEVKGVTYCGYPGSS
NLTIKNSPWHEEVKKFVEDLCEEINDPRYRTESSSGESKDGSTLEYGLAAEHAHSCCVLA
AHSKYYFDDKWHTWIDYDKFFELVEAGSTDFDGLDYCDITPDFALFNSAEAGFSPEDQRW
FRKKTLAAQKEKLDQLNQDHQKEDDQNILPPPIGPSQ
>A0A7K9Q1F4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pachycephala philippinensis|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPSEKSHGN
PASSEGTADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVI
NMGDYDPEDGLSEETNSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQG
LRYAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WKAKFLTRLQTLCRGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFET
SSEEEAGGTDSVIDVEDLGNIMGHMKKAKVLLLEGAHGVNHSGYQLVYFVCQFLQAKLNC
LMIFALLLGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPELILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKH
CALSLVGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTQE
SLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDF
IEVK
>A0A7M7P845|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strongylocentrotus purpuratus|TrEMBL
MWNKLQWIGLTYVVILIQESNASNADDDRDMWAWQAGWQWVWLAVAVVIGIAIFSRQRKT
SQQADKESRQNKSTSPVDPQASLDVTSIKIFYGTQTGTAKNLAAQLAKDIPDTVNTDVID
LKEFDPEKHVLLDQDEQTVCVYILSTYTDGEPPEGGAWFCRWLHESVNDFRVPGTLLKGH
QFAVFGLGNSLYQDHYNTVSKKVHQWLIDLSARPLLPVGEGNGNVAASKHGGTEADFAAW
KSDFLQAVLKCDGSGDKSCSCNQNGTCQSSVIGQMSLEQNTVTPERDGGGEEKADDGLDS
DQEDPDEMDVIDVEDLGSVMNKMKNAKAMNGVKLGTEPKEMVTPTIRKNLTKQGYRIIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTE
WKWQMDDAESIVEGALKNHYNLIKQFKGVPGVKPERMKEAMKAQHCALSLVGEPIMYPKI
NRLVELLHKEQISTFLVTNAQFPDAIKNLLPVTQLYVSVDASTKESLKKVDRPLFRDFWP
RFLESLKALSDKGQRTVYRLTLVKAWNDEEIQSYADLVQLGKPDFIEVKGVTYCGESKAS
TLTMQNIPWHEEVVHFVQKLMDLLPEYEIACEHEHSNCVLTANTKFKRDGEWWTWIDYSQ
FHALMAEYDASGGEKIFRAEDYMAKTPPWAVYGSKEQGFDPEETRFYRKGKKKDLGGC
>A0A7K6A083|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Onychorhynchus coronatus|TrEMBL
LDVSMDTWSYFRTCLVSIWLHRFYIYAVVALGISLWVVIQFTTTKTKKKVTEPGEKSSGN
PTSSKGTEDKLVNGCATPQAKEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVI
NMRDYDPDDCLAEETTSGNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRVGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRRMDRWLWMLSASRVMTRAEGDCNVAQSRHGSIEGDFEA
WKAKFLTRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEHENTEAEELFET
SSEEEADAEEAGGTNSVIDVEDLGNIMGHMKKAKVLLLLWVGSGHVFATDHSSLFFALFS
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFRGVSGVKAARFEEALTVKHCALSLVGE
PIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTRESLRRIDRP
LFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLGKPDFIEVKGVTY
CGESSASSLTMANVPWHEEVVGFVRDLAELLPDYEIACEHEHSNCLLLAHTKFKVDGEWF
TWIDYERFQELVRERERSGGSRSFTAADYTARTPPWALFGARERGFDPLDVRFQRRNKAR
DISGC
>A0A5M8PBU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lasallia pustulata|TrEMBL
MLSSFGHQSWMDELTQIWHEYRILILGGLLNGMSLAWIMLVWLPRWWRRRERLSSSPNAG
SPSLAPAAIERNPVLDDKGASFAAEEEQHETRTQTTTESVAKDVEKTASRPRLGPKRVTR
TIPRKPTRTTGGQSEDERITQQMKVQPLVFFSSLTGSTERYATEFANSFRLQSDAVSDTT
VLDPQLHDLSYIDYDEFFITPPRSNGPTDRIQYFYLLLVPTYNIDTVLNTFLAHLQETHH
DFRIDTGSMSGLLGYSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAFPLGMGD
VKSDALARLEEWGSGVKEVLNDLIINGGLGEGVSGSGDAVESDDEDLETAEANALKPGNP
MLKKSRLSKSNRTANVDDLEDLGDKVPSNNSSANDPASSTTPLAIDFTTSSCTSQPPAAT
QSLKEMVPITSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLC
METTPSLSCSNKCVFCWRHGTNPVGTTWRWRVDPPDLIFNGVKEGHYRKIKMLRGVPGVR
AERFAEAMRIRHCALSLVGEPIFYPHINDFTALLHRERISSFVVCNAQHPAQLAALRPVT
QLYVSIDASNRESLRRIDRPLHRDFWERFQACLDVLREKRGVQRTVFRLTLVKGFNVDEE
VEGYAGLVERGLPCFVEVKGVTYCGTSDSKGAGLTMQNVPFWEEVEAFVVALSAALARRG
LDYGLAAEHRHSCCVLIASKRFLIQGKWHTTIGYDKFFECLESGREFGPEDYVGDPTPEW
ALWGKGGFDPADERVYRKGKNRQGWGRWGGETAGVVKAVGMRNKSSSELM
>A0A384JZ24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryotinia fuckeliana (strain B05.10)|TrEMBL
MAYDSWISRPVWSFGIDDVVALWHLYRIPIILTTATILILVRITLRPRALREKLSASPLP
TSPILSAAKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTANSFVKSLTRDLSGRANEQRIQFLESQLLDLSYIDYDDYFINPPKGESGTSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVDDVEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTASEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTG
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASNRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDAGEDKVAEDSTKDDLAF
>A0A3M7GIL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSRATANQDAQVIEKVQPI
IFYYTLGGSTKVYAESVAQNVAASSPSSILPPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKHEADIMLKEWTEGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETPAPRKPKRKPAKRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALANRG
LAYGIGAEHAHSCCILLADRERFFRVPEAEKDNPAAEKKWHTLIDYPRFFDCLESGQPFA
PEDYVGAPTPEWALWGNGGFDPRDERVDRKGRPKEPKVQEVQEVQE
>A0A8H4YZB6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium anthophilum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YDEPAEPKVVVEEKTPAIEPVEEKKNVRSQGPRRIKGGIARKPSKNKEEEKDTTRPVAPL
VFFSSITTKTAKIAEAYIADFCGKLDELSKLSGRQFLKPEVRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVREVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSSRDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A2I0AJZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apostasia shenzhenica|TrEMBL
MTPVSPSLHARLALLALLSLSSAFCLWKSNTLRRRRRLQPSVPSSLRKQYDRPAKIFFAS
ETGTSKSLARRLAVRLSAHGIAAELVDPRDYEPEELPRETLVFIVASTWEKGKPPPNAAF
LASWLAESAKDFRVGSLLLSRCEFAVFGVGSRAYGSTFNVVARDMARWMRALGAVEMTPL
WDGDVDGGEVEEEFNLWIERVLSLVKGEKSLADEFEVFQDEEEYYEEYGEAEAAEDGVVD
LEDIAGKAPLKNSKVELLNGNGSIKEMVTPIVRKNLEKQGYKIIGSHSGVKLCRWTKSQI
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDDPLVIVDA
AIEEHTKMVKQMKGVPGVKEEQLLEGLSPRHCALSLVGEPIMYPEISALIDELHRRRIST
FLVTNAQFPERIKVLKPITQLYVSVDAASKGSLKAIDRPLFGDFWERFLDSLKALRNKQQ
RTVYRLTLVKGWNAEEIDAYANLLSIGEPDLIEIKGVTYCGSSATSKLTMENVPWHLDVK
AFSEALAFKSNGLYEVACEHVHSCCVLLAKVDKFKISGQWHTWIDYERFHDLVASGMPFR
TEDYMAATPNWAVYGALEGGFDPNQSRFKKERRHGVAALKSG
>A0A7K4FS69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus sp. RZ1|TrEMBL
MTISSFRIDTLSKIMSEMEKQKYHIIGSHSAYKKCHWTHEALTSGRYCYKGKFYGIESHR
CVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDETKMPILDDPEYIAERSIEEHKRAVSGYF
GHEEVDKEMAKEATKPAHVAISLTGEPTLYDKIGELISEYHKKGMTTFLVTSGVRPDVLA
NLEEEPTQLFVSIQAPNERKHKMINRPIVPNAWKLFMETLEILPSFSSPTVIRMTMIKGY
NMSEEDAKEFAELIKIAMPTYIEVKAYMHVGPSTLRLTRDAMPRHTEVKEFANILAKFTG
YNIISEHVPSRIVLLSKIDRPIQIGNAWTDRWNWSTKDMDDDINGEYKEAETGCTEG
>W9VRJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cladophialophora yegresii CBS 114405|TrEMBL
MDMGEEAAPVVILADWLDRLLTFWHDNRFLLASGLVLTVLAIIVRRRRAAARSALRDSSP
SLEKADWLAVDDSSAKTATNEKKNEATSIYVDQLTSGQARKPRPAAARVVTGRKPVSSRG
HTSPQRQTKPSCLQPLVFFSSLTGTTEQLSERVAAELESLATTQPTILKPEVYDLSYIDL
DDYFISGPKIPKPAANVRYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLASLAG
YAVFGIGDKEGWPTEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSSIEQATEEWTG
GVCHVLQELSVSGTLGDGVPGSGAAVESDQEDEPDAGHDNDDDFPDSGRNKRRKLANTTD
LEDVGGESAPMAIDFTTYSSLPAPLKAMVPRESPTHAALTKQGYTIVGTHSGVKICRWTK
SALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPEMI
FNGAKEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLHGER
ISSFLVCNAQHPQQLNDLRRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNSCLDILRA
KRFEQRTVFRLTLVKGFNVEDEVEGYADLVAKGLPCFIEIKGVTYCGTSTSSSAGLTMQN
VPFYEEVVAFVEALNAALAKRGLEYGIAAEHAHSCCALIASKRFLVDGKWHTIIDYDRFF
ALLEGGQDFKPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEASKTDEVAKGRKAGTG
LVVAVQSGGLDF
>A0A218P6N3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus pacificus|TrEMBL
MAITFVSNPNMPEEMARLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
REDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWDRIKETLALMRDAQTRTVIRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKYLPGY
HIEDEYEPSRVVLIMRDDVDPHGTGVNGRFIKH
>M0D0B3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halosimplex carlsbadense 2-9-1|TrEMBL
MSESDGPKQVSDPEYHSENHTAAQTCGWTANSLRGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPSAVADASLELQKKLLSGFGGNDQVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFRERDITTFLVSNGTKPEVLAECDPTQLYVSVDAP
DRWTFDNTVKAVEDDAWERLIDTLDVLAAKDETRTVLRTTLVNGRNMHHPEWYASMFQRA
DPDFVELKAYMHVGHSRGRLDRDAMPDHEDVRAFTEDVMEHMPEHDHLNDVPVSHVTLLS
KTEDTWVPKLQKDSEFWERDPYAEVGD
>A0A8C6VBM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Naja naja|TrEMBL
MDTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKNCLAELNLSK
ITVAEKEQRDPSFEKVHVAGVKVFYGSQTGTAKRFALVLTEAVASINLPAEIIDMQDYDP
DDSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHGSIEADFEAWKAKLLI
RLQALAKGEQKACSGRCKKGQCRSKSKVSQEAKEQETSEHVENEEEDFFETTSEEESDTE
NGRGADQVVDVEDLGKVMDQMKKSQKEHQTNGVIPIGVGTQHGRGEDERREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALS
LVGEPIMYPQINQFLKLLHHHNISSFLVTNAQFPDEIRNLQPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIK
GVTYCGESSASNLTMANVPWHEEVTHFVQDLADLLPDYEIASEHEHSNCLLIAHKKFKIE
GKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKERGFDPVDTRFQRK
NKIKDISGC
>A0A8C9GW07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Piliocolobus tephrosceles|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKTQDRNLQEKSVPKAPQN
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAQWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYSSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRVWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A2Z5PK07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis OS7|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCLRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILSENSIFKIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A0D3CWI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica oleracea var. oleracea|TrEMBL
MASSSSIHSRLALIALLSATTFYCIHKYRRLKRLKNLSSKLNPSAATRGKIFFISQTGTC
KALAQRLRDLLASNGVAFDLVDPRSYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWL
SESAEDFRVGSLILSGCRFAVFGVGSRAYGESYNAVGKELSRRMVGLGGVEMVPVGEGDV
DDGEMDGVFQDWCDGVIRVLKGGSAREGAVGLVSDGEYVDSTDDEEEEGNDDIVDLEDIA
GKAPSRKNGVVKVAKGDGKKEMVTPLIRASLTKQGYKIIGSHSGVKICRWTKSQLRGRGG
CYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKGALDLH
TKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRISTFLVTN
AQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQRTVYR
LTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVKAFSEA
LSLKSNGEYEVACEHAHSCCVLLGRTDKFKVNGKWFTWIDYEKFHDLVASGEAFTSRDYM
AETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQVVVA
>A0A2I0PT95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon HGW-Methanomicrobiales-1|TrEMBL
MPSAPCNALRKQGYQFFSKTSGAALKPCMWCKRALMGGDMCYKHQFYGIDSHRCVQMTPT
LRCNQRCLFCWRSYEEEMPEEKECSPETILAGLHKFQKKALAGYNSILDNTVTSEKWQEA
LDPKHVAISLSGEPTLYSQLPALIDLFNDKGYTTFLVSNGTNPDMLRRCHPYQMYVSLDA
PDRETYIAVCRPEEDYWEQVNESLALLGTRRSAVRITLVKGLNDFSPEKYAAILQDSGAS
FVEVKGYMYLGYSRNRLARENMPAHEYVRSFAEKIAAACDYRFKDENILSRVVCLERIT
>A0A1V4VA52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaB.Bin087|TrEMBL
MIERFPPTMAEMLKRQGYHLVAHGAVKPCLWLRRSIRGGDQCYKHHFYGIASHRCVQMTP
TLLCNHRCLHCWRPIDEIPTASGDWIEPPELLDGILSEQQRLISGYGGAPETTDLTRLEE
ARRPAHVAISLMGEPTLYPMIGELVDEVKRRGMTAFLVTNGTIPEVVGEVRPTQLYISLN
APDEETYLRVSNPRDDYWGRFLESLATMRDSPSRTVARLTLARNLNLKDPQGYAKLIEIA
EPDFVEVKAYMHLGLSRKRLERDSMPTHDEVMSFAGELSDILGYTLKNHVPLSRVALLSR
GSSPEKIEL
>A0A024VBI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum Vietnam Oak-Knoll|TrEMBL
MEQLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIG
NDEKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSMGIVEEEFLLKNI
LGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFFKDINDIINKNIYI
NNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDKNNCVNNSLDIKDM
NSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYLEPYEENVKMFNSK
FKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFFISTSSHGSFPNNS
YKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKKCEKYIHLLGAQKL
YKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWTGENCVSESETSSNQSYP
DDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCY
KHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKA
MIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQ
FPQELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFT
LVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWN
LINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALD
YSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A1Z8JNA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pichia kudriavzevii|TrEMBL
MNEHIVALGAFAAFLYLAGKLGLLLLIVMCVGLMYCSKDVANGGDSVKRRSRRGNKSKVI
PPSITKMRKAKDGEELYTGSQNPLGESPIYIFYSSLTGASKRVALQLYDTLNASLGAPLS
LVVKLLSLDDDVEDLDDYFLNVPKLDKPPIYLLVLPSYESDSPIDYFLEMLRETSTDFRV
DKYPLRALAGYAVLGLGDSESWPELFCYQGKLADKWLSKLGGRRVFPFGELCVKSSNFKK
SCEEYTKRLVDLLLDDDPFLYEEDDDDDEDEDASMDDEQLTNSDDDGNGGGSSDDGTLVD
VEDLQRNEKRVNLVDKKKMVAKDSPTYKSLTKQGYTIVGSHSGVKICRWTKSALRGRGFC
YKFAFYGINSHRCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWEVDKPDMILNGALEGHY
KKIKQMRGVPGILIDRFNEAFKVRHCALSLVGEPIFYPYINQFLEMLHDKEISSFLVCNA
QHPDQLSTLGKVTQLYVSIDAPTKEELKVVDRPLFRDYWDRLERCLDILRTVQSHQRTVF
RLTLVKGFNMSDESVGGYADLVERGLPALIEIKGATFCGSSEGNGNPLTMQNIPFYEECV
KFVKRVNEELNNRGLEYGLACEHAHSCCFLIASKKFLVDDKWYTHIDYERFFELLKSGES
FDKMDYISETPEWAYFGSEQGGFNPDDTRWNRKEEKLKKKAERERVAATATATARGETAT
ATTAVDVVVDGPN
>A0A2R6DVX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QH_7_69_31|TrEMBL
MPKQVSDPDYHSENHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELDGVEWDDPEAVVDASIELQRKLLSGFGGNDDVPRDVFEEALEPRHV
AISLDGEPTLYPYLPELIEAFHDRAITTFLVSNGTRPEVLAECDPTQLYVSVDAPDRKTF
GEVVRAVEDDAWDRLIETLDVLAAKDQTRTVLRTTLLAGYNMSHPEWYAAMYDRADADFV
ELKAYMHVGNSRDRLDREVMPDHADVVAFTEAVGEYLPTHPVLRDVEVSRVALLAREEDT
WVPELKGGSEFWGRTPYASS
>A0A2R6KU42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_10_68_16|TrEMBL
MSDSEGGPKQVDDPDYHSENHTATQTCGWTKNAMRGEGKCYKNVFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELDGVEWDDPEAVVDASIRLQTKLLSGFGGNDQVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELVEAFHDRDITTFLVSNGTKPEVLAECDPTQLYVSVDA
PDRGTFESTVKAIEDDAWESLIGTLDVLAAKEETRTVIRTTLVRGHNMHHPEWYAAMCDR
ADADFVELKAYMHVGHSRGRLDRDSMPDHSEVRAFAEAMREYLPDHDVLKEVERSRVAML
ARESDTWVPKLQKSSAFWERDPVRS
>A0A5C6PAM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu flavidus|TrEMBL
MQGSSRVLFSLSNLTSFVTMFCVFAIVFLLIHHAFSSDSKEQQKSHISADYFMAIWHNRL
YLYSTAALIFGIWFSLKMAIKKKNQVSNANSLAYKPVKKNDNDSMVHVSGVKIFYGSQTG
TAKGFAKELSDEIKALGIPAVVLDMKDYDPDDELAVECTNKSVCVFLVATYTDGQPTENA
EWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGKRIM
TRAEGDCNVVKSRNGSVQADFLAWKVKLLKRLQALARGEKKICSGNCKTEGKCKNKRKVK
GEENAALQNNSSEGELIESSSDEEESGLQEEKQSGTMLDMEDLGNIMNLVNKTKSNENGR
GKGQTVKLSKLNGLKKTEEEEDVREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDA
LEKHQNMIRQFRGVPGVKLERYEEGLQVKHCALSLVGEPIMYPEINTFVRLLHTHNISSF
LVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDYWPRFLDSLRALGEKRQR
TVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVA
FVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQDLVGIYEKTGGQR
SFSALDYMAKTPSWAVFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A8H4P6I8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium austroafricanum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHIYRTPILWIIAISLVVARFYFHINGQKAEIVAFKEI
YEETARPKVVLEEKTPTIEPIEEKKKVKSQRPRRIKGGVARKPSKNKEEEKDLTRPVLSL
LFFSSITTKTAKIAEAYIEDFCGKLDELSKQSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDTENWPT
EADGFCFQAMEIDKWMAKLTARKRAYPVGMGDMKSDHEERLHEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKTKGGRDLDDVEDLGRMIRKDDS
STTQKAPLAIDFTNYGSPKKKSVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKICRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
MIFEGVKKNHYQKIKMMRGVPGVRAERFAEAMQIRHCALSLVGEPIFYPYINEFLGMLHE
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
RKKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVNGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEAS
>A0A673C1T5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
MLASWMNLKVYLSFSYFQLSEEVQTLGLTCEVIDMKEYDPDDRLADECTSRSVCVFIVAT
YTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKW
LWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVKFLNRLQNLVKGDKKSCSGNCKNG
GSCKNKRKDGHGQEEEEDAVTRQNDGSEVMDGRLLSHGWCLKAKSKEEGQMVKLSKLNGV
KKVEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKILQDSLEKHENMIRQFRGV
PGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPQEIRSL
VPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFQDSLRALGEKRQRTVYRLTLVKAWNVE
EMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQVHEDSGGQQSFSALDYVAKTPRW
ALFGAEEQGFDPNDTRFQRRNKTKDISGC
>Q5BG28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)|TrEMBL
MAESTAAEGLLTLWHSFRLPLLVALATVFVIVRLRRVFQARPKIATASSVPSSPRSSSPE
KTTKSVASSLSEKKDVAVPNGGRVSPKPTAGPKRVTGKKPLKSARKRSSSISDEEKQPVT
HIQPIIFWASLTGSTERYAQVLLEDLRAAAQSQADPENRERGLLPPQIHDLAEVDYDDYF
TTAPKPPPTSPGTRYVYCFLIPSYNIDTILDTFLGHLDETHHDFRIDTGSLSTLAGYAVF
GFGDKEGWPTEEEGFCSQAKELDRWMAKLTNKKRAYPLGFGDVKSNADASLKEWSAGLQD
ILSDIVKNGGLGEGVPGSGDPLESDEELSDDEDSGSGKSKARRKPQSVVDLEDIKMGSNG
QAVGSPIPVDFTTSGASRDVQPTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKS
ALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIF
NGAKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDLLHTEHI
SSFLVCNAQHPDQLQALNRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREK
RHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEVKGVTYCGTSTSAGAGLTMKNV
PFYEEIAEFVVQLNAELERRGLDYGIAAEHAHSCCVLIASSRFRVNGKWHSRIDYPRFFE
LLEKEKADGTSFRPEDYMKETEEWALWGNGGFDPNDERVFKKGKAAKKALKEKEEKEAAE
RAAAAE
>A0A670Y4B4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudonaja textilis|TrEMBL
MDTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKNRLAELNLSK
ITAAKKEQQDRSFQKVHVAGVKVFYGSQTGTAKRFALVLTEAVASINLPAEIIDMQDYDP
DDSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDSNVVKSQHGSIEADFEAWKAKLLV
RLQALAKGEQKACSGRCKKEQCRSKSKVSQEAKEQETSEHAEKEEEDFFETTSEEESDTE
NGRGADQVVDVEDLGKVMDQMKKSQKAHQTNGEVPIGVGTQHGRGEDERREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILKEAIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALS
LVGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIK
GVTYCGESSASNLTMANVPWHEEVTHFVQGLADLLPDYEIASEHEHSNCLLIAHKKFKIE
GKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKERGFDPVDTRFQRK
NKIKDISGC
>A0A832SM26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus horikoshii|TrEMBL
MTIKPGKITVQANPNMPKEVAELFRKQHYEIVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMENFLGTELPQPWDDPAFIVEESIKAQRKLLIG
YKGNPKVDKKKFEEAWNPTHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTIPER
LEEMIKEDKLPTQLYVSITAPDIETYNSVNIPMIPDGWERILRFLELMRDLPTRTVVRLT
LVKGENMHSPEKYAKLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHQDIREFAEALVK
HLPGYHIEDEYEPSRVVLIMRDDVDPQGTGVEGRFIKH
>A0A2V5IN84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus indologenus CBS 114.80|TrEMBL
MAEFAVDEGLLAFWHFYRLPLLLALVAAFTFIRFYRTLQPKSRTATASSIPPSPRSLSPE
KSEKLAIGYDEEVTKVEKSTIQTIAEKEKAPKSASGPKRVSGKKPSKVAGRRAGSDQDQQ
PLSFIQPIIFYASLTATTEKYAQVLLEDLRAAAQERADPENRERAILPPQIHDLSYVDFD
DYFAAAPKPPSNSPGTRYVYCLLIPSYNIDTILNTFLGHLDETHNDFRIDTAPLSSLAGY
AVFGFGDKEGWPTEEEGYCYQAKELDRWMAKLTGRKRAYPLGLGDVKGDAEAALKEWSHG
LQDILGDILENGGLGEGVPGSGDPLESDEEDLEEEGSDDSSKKNRKRNKAQDVVDLEDIK
FSADSQSGSGAPVPVDFTTAGASPASAIQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWK
VDSPDLIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFL
DMLHSERISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLDILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAG
AGLTMQNVPFYEEIQEFVTSLNKELERRGLKYGLAAEHAHSCCALIASERFYVNGKWHSR
IDYDRFFELLEKEKADGTPFKPEDYMSETLEWALWGNGGFDPNDERVYKKGKKKGLQAAA
AAQD
>A0A2H4U7R3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter smithii|TrEMBL
MSLNKKQVEKLESSGYRFVGSHNHAAAKICHWTKQSILDKGVCYKEKFYGIESHRCLQMA
PAVPNCQQKCEFCWRDLSYTQTQWEGEYDDPKTIIDEAVKAQNNLLCGFFGNDKANKEKL
EESKTPTNAAISLAGEPMLYPEIDELIAEFNRRNFTTFVVSNGQCVDKLKNLENEPYQLY
LSLDAPTKKIYNDVCQPQISEGWDNLNQSLDTLASFNSRTCIRTTCVKGRNMTNPEKYAE
LIKKASPDFVEIKAYMCVGSSRHRLTPDNMPTFDEVKSFAQKIGENCSKKIVNESEVSRV
VLLQ
>A0A2H4ZUW4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula taiwanensis|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFEQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRRTFDSTVQAMEDDAWDSLIDTLDVLAEKGDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTRKMSEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A151EP93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon SG8-52-3|TrEMBL
MKKEFRKILEKQHYGIVGNHSGVKLCHWMRQSLLYSRECYKQTFYGIKSHRCLQMTPSIN
QCNHLCLFCWRHQGFNEKEFKEIDEPEYILDKSIEIQKKLITGFKGDKRCSQEKWVEANN
PNMLACSLSGEPTLYPRLGELFEICNKRNITTFLVTNGTNPKALENLDPLPKQLYVSIVA
PNKEVYKKLCSPLISDGWEKIIQTLELLPSLDTRTVIRHTLVNRWNISDKFIKDFTSLDK
IANPLFIEPKGYVFVGYSRKRMTISNMPSHSSIKIFGKTLAKNLGYELLMERPDSRVVLL
SKQTKMARFDK
>A0A2R6K7P7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_9_67_17|TrEMBL
MSDSGPKQVDDPDYHHVNHTAAQTCGWTANALRGEGRCYKNRFYGIQSHRCIQMTPVVKC
NERCVFCWRDHAGHAYELDDVEWDDPEAVVDASIELQRKLLSGFGGNDEVPRDVFEEAME
PRHVAISLDGEPTLYPYLSELIDAFHDRDITTFLVSNGTRPEVLRACDPTQLYVSVDAAD
RHTFEETVGAVEDDAWPKLLDTLDVLADKESTRTVIRTTLVDGVNMHTPEWYAAMCERAD
ADFVELKAYMYVGHSRGRLDDANMPDHDAVRAFAEEMREFLPDHDTLREVPQSRVALLAR
DEDTWVPKLKGGSDFWGENPYA
>S3CRV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glarea lozoyensis (strain ATCC 20868 / MF5171)|TrEMBL
MKYDAWILSNVWPFNTSAYAEAVEVWHEYRIPIIISTFTILMIVRTVLHTRLPREKLSIT
PPPASPTLAAEKKIAPVGTGNKKPISEKVTEKVPRRIVGGVKKRNSSQDDVVTGDEKIQV
LVFFSSLTTTTEKTAKVFTEGLAQKLKSVNKASRFIEPEILDLSYIDYDEYFINPPKSDS
NVQYFYLLLVPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTE
ADGFCSQATDIDKWMAKLTARKRAFPLGMGDPKTDATERLKEWKDGVEDILEHIAETGGL
GEGVVGSGDAVESDVEDVDEDDDGEVLFAEQKVAQKKTKSSKKDDMNDMEDLGKTLNKIA
AEAEESGEIEIDFTNFSKKAKKPTAAPVIKEMVPKDSPTFNSLTKQGYSIVGSHSGVKIC
RWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDP
PEMIFDGVKAGHYKKIKMLRGVPGVRSERFAEAMRIRHCALSLVGEPIFYPHINEFLSML
HAERISSFLVCNAQHPDQLATLKHVTQLYVSIDASNRESLRKIDRPLHRDFWERFNACLD
ILKKRRFEQRTVFRLTLVKGFNIDDEVEGYAALVEQGLPCFVEIKGVTYCGTSSSASAGL
TMQNVPFYSEIQEFVLALTAALQKRGLGYGIAAEHAHSCCVLIASDRFKNERGKWCTRID
YQRFFELLEGGGEFRPEDYMGEETPDWAQWGNGGFDPRDERVYRKGKNKVPLAVKAEEEE
GGE
>A0A017S962|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus ruber CBS 135680|TrEMBL
MDCSSAMLEGVVVFWHAYRLPILITLSTLFVFVQAYRKLQPKFKTEASSSLPPSPRSHSP
EKSEKIPVSDGTKKEPPAVSKSTGPKVVTGKKPVKGGKRGGSDETPPLSFIQPIVFFASL
TGTTERYAHMFVEELRAAAQNRADPENRERGLLPPQLHDLAYVDLDDFFTSAPKPPSTSP
GTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTGSLSQLAGFSVFGFGDKEGWPTE
EEGYCSQAKELDRWMAKLTGKKRAFPLGLGDVKSNAEQALKEWSHGLQDILYDILQNGGL
GEGVPGSGDPLESDEEDFDDENETDVAKPKSKRGKGQSQSVVDLEDIKVNPDSPAPLAVD
FTTGGKSEPQAKEMVPKTSPTYASLTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGIKSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDDPDMIFDGVKDGHYKKIKM
LRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDLLHSERISSFLVCNAQHPDQ
LETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRNVQRTVFRLTLV
KGFNVEDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEEITEFVLAL
NEELERRGLKYGLAAEHAHSCCVLLASERFHVNGKWNTRINYERFFELLEKEKADGTSFA
PEDYMDETTEWALWGNGGFDPNDERVYKKGKKAKVQKELANSTANEA
>H2YWM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ciona savignyi|TrEMBL
ILFGSQTGTAASYAHAIQEELNGKGIKSKLEDLKNFDPEDNFLYWNVRILFLISTYTDGT
PPPSCEWFCRWLQDASNDFRVNKSLLSNMRFAIFGLGNSLYSDHYNTVSLFLMELEISLS
ATRIFPFTAGDENVVQSKHGSIKLDFNAWKSEIISVLEYLLAGNQKNGVVTPVAEIDSVS
STTQCLEEEEEKGEEGEDVVDVEDVGDAISNGTNGVSMRKRNSKKPPEMITDELRKSLSK
QVYYILLFSCYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHSNPVGTEWKWKMDPAVDVIKGAIENHYDMIKQFKGVPGVKADRFAEGFSIK
HCALSLVGEPIMYPEINDFIQMLHEKGISSFLVTNAQFPEAITTLLPTTQLYVSVDAATQ
DSLKKIDRPLFKDFWPRLIESLKALSLKGQRTVYRLTLVKAWNVDELEAYADLVALGKPD
FIEVKGVTFCGDSKSSDGLTLKNVPWHDEVLHFVSQLTDMLDGYEIACEHEHSNCVLVAQ
TKFKSANGEWRTWIDYARFHELFQRFRATGESFTALDYTATTPAWAVLGADERGFDPQET
RWRRK
>A0A0J8QTB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides immitis RMSCC 3703|TrEMBL
MPDETFASGAQRALSLWHSYRGFSTVDTFTSPVLESQTKPSNLGDRATYLHHHSGGGNPF
AECAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDATKEISIQPIIFFSSLTGSTERSAKR
VLERLNTEPLKDSKRSSRLLAPQLYDLSYVDFDDYFVSPPKAPESNPNVLYFYCIIIPTY
NIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAVFGFGDKEGWPTEEEGFCSQAKEVDK
WMAKLTGRKRAYPLGLGDVKTDGDKALDEWCSGMQEVLSDMVTNNGALGEGVPGSGDPLE
SDEEDVEEDDEGVPNPGSRPRKARRAEITDLEDIKFGGDASGKQGSDIPIDFTTYSKTST
SVATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIK
SHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPELIFQGVKEGHYKKIKMMRGV
PGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVSMLHSEHISSFLVCNAQHPDQLAAL
DRITQLYVSIDASNRDSLRKIDQISGSASSAAWDIIREKTHVQRTVYRLTLVKGFNIDDE
VVGYADLVERGLPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEEVAAFAVALNDELNRRG
LGYGIGAEHSHSCCILLASRRFHVDGKWHTKINYERFFELLEREKAEGVSFTPEDYMSET
DEWALWGNGGFDPNDQRVYRKGKNKANMSDAGSVPKGGVVEI
>M1I572|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus acidocaldarius N8|TrEMBL
MEGQLKIDTFSVIMKELEKEKYHVVGSHSVYKKCHWTHEALTTGRYCYKGKFYGIESHRC
VQMSPSAAWCWFRCIHCWRLEPEDIGIEWDETKIPIEDEPEIIVERSIEEHKRAVSGYFG
RNGVPKNKVIDAATPRHVAISLTGEPTLYNRIGELIKEYHRKGLTTFLVTSGVRPDILAS
LEEEPTQLFVSIQAPNYKKHKIMNRPIVPNSWELFLETLKILPSFSSPTVIRMTMIKGYN
MSEEDAKDFAKLIELSQPTYIEVKSYMHVGPSTYRLTKDAMPKHNEIREFSKILANYTGY
KIISEHVPSRILLLSRLDKPIQIGNAWTDKWNWSTKDTEDDMNGEYKEAEESCTEGGI
>A0A672RVN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus grahami|TrEMBL
MLFKKEKTVDPVSPWLYKSAKKQELSAETEKVIHVSGVKVFYGSQTGTAKGFAKELAGDV
SAQGIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLEEASTD
FRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSR
HGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGSCKNKKKHKEEAEDSHSLAEKNN
SEASQPSSLMSLNTCSHGNSSCTAHPESRLFPCSLWWYKLIGSHSGVKLCRWTKSMLRGR
GGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVE
NHRNMIRQFRGKDSPERRCLLPSAELFCRLQTNNSGLKGSLVPITQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHNKFKV
DREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRFQR
RNKTKDISGC
>B6QNL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)|TrEMBL
MADSSLVPGLLATWHSFRIPIIVSLAVFFLFVRFTSSKRSKSSLSSSPPPSPRLESAILK
EKPVAPIPEQKSVTALKPAPKPLASGPKRVVGNKDRRVGKNSQKSDGIGGPSYIKPVIFF
ASLTASTQTHAQWLLEQLRTAAQEKSPGNDNEWGLLPPELYDLAEVDFDDHFITAPKAPV
NSPNTRYVYCFLIPTYNIDTIIDTFIAHLDETHNDFRIDTAPLSSLAGYSVFGFGDKEGW
PTEEDGFCSQAKEIDRWMAKLTGKKRAYPLGMGDTKTDAINALKDWTSGLVEILLEVAQT
GGLGEGVAGSGDPFESDEESAAEDEDQPSSKKTQTVVDLEDINFGGSAKKGKGDPIPVDF
TTVSKVQTSQAALKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNGVKEGHYKKI
KMLKGIPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHNEQISSFLVCNAQHP
DQLATLDRVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILREKRHFQRTVFRLT
LVKGFNIDDEVKEYADLVEKGLPCFIEVKGVTYCGTSSSAGVGLTMKNVPFYEEVVAFVV
ALNDELERRGLGYGIGAEHAHSCCILLASDRFKVDGRWHTRINYDRFFELLEKEKTEGIS
FRPEDYMRETEEWALWGNGGFDPNDQRVRKVRNKKLKNDQTAEQNMTF
>A0A842UKV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MLEDEFKKLLLKQHYKLVGNHSAVKLCGWTKKSIKGVGVCYKEKFYGIDCHRCLQFTPSV
EYCNHRCVYCWRNIEHTKSSEMGMVDEPSEIIEEAERKHRLILTGFGGILDDINESRWRQ
AHQPNQAAISLAGEPTYYPNLGELISEFGKRGYTTYLVSNGTRPKMLECLSKLPTQLYVS
VDAPDEKTYKGLCQPVVGGGWSKLNESLSLFPSLDTRKVLRLTLVEGLNIFDVKGYAKLI
EKASPDFVEAKAYMFIGGSRHRLSLDNMPSHARVREFAEEISRETGYALAGEQRESRVVL
LEK
>A0A6A9SN54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronomonas sp. CBA1123|TrEMBL
MPKQVSDPDYHSENHTAAQTCGWTANALRGEGRCYKNHFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELGDVEWDDPEAVVDASIDLQRKLLSGFGGNDDVPEKVFEEAMEPRHV
AISLDGEPTLYPYLPELIEAFHDRGITTFLVSNGTRPEVLAECDPTQLYVSVDAPDRKTF
GEVVKAVEDDAWDNLIETLDVLAEKDETRTVLRTTLLNGYNMKTPEWYAGMFDRADADFV
EMKAFMHVGNSRDRLDREVMPDHEDVVAFTEAVGEYMPDHPVVRDVPASRVALLAHEEDT
WVPELKGGSDFWTEGSYAKGTSD
>A0A847UPZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula argentinensis|TrEMBL
MSDADDGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRELLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDPLVEY
>A0A8D0N7J7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMGRVKKEKREKAQQEGETGVLRSAVKNEASEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRYQR
KNKAKDISGC
>A0A832WL66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanopyrus kandleri|TrEMBL
MLHADVLKVLRKQGYGLVGKHSAVKPCHWCREAIKNGRHCYKAKFYGVESHRCLQMTPTV
AWCQQRCVYCWRPVELTVGTHDVPDPDDPDLIVEESVEQQRRFLQGYGHLEGEARKRWKE
SLEPRHAAISLAGEPTLYPRIGELIDAFHSHGFDTTFLVTNGLRPDRVEELEREPTQLYV
SLDSPNEELHRQINRPTIPDSWDRIMRTLELLNSLSCRTVIRITAIKGWNMEGTAEEFGE
LLADVEPDYVEVKAFMCVGWAAFRMSPDNMPSHEEVRKFAAEIAEHAGFELVDESPPSRV
ALLSS
>A0A2T9WTA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. SCGC AB-777_L09|TrEMBL
MESKVRIDTFSIVMRELEKEKYHLVGSHSVYKKCHWTHEALTSNRYCYKGKFYGIESHRC
VQMSPSAAWCWFRCIHCWRLEPEDIGLDWDETKIPYEDEPEIIVEQSIEEHKRAVSGYFG
REGVSKEKVVEAMNPKHVAISLTGEPTLYSRLGELIKEYHKRGLTTFLVTSGVRPDILAS
LEEEPTQLFVSLQAPNEKKHKLINRPIVANSWNLVMETLKMLPSFSSPTVIRMTMIKGFN
MSEEDANEFAKIIEIAQPTYIEVKAYMHVGPSTYRLTKDAMPRHSEIREFAKLLSSLTGY
KILSEHVPSRIVLLSKLDRPIQIGNAWTENWNWMTKDIEDDIHGEYEQAEKSCTEGES
>A0A7C5TBD1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPESLIQVLKKQKYHIVGRHSAVKRCKWLYEAIVHGRSCYKQKFYGIKSHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETRLPEKWDSPEEIVEGCIKAQLDILSGYKGNPNA
DSQKLREALKPRHAAISLTGEPTLYEPIGELIYAFHRRGFTTFLVSNGTVPSVLAKLDHE
PSQLYVSVCAPNKETHKKVCRPIIPDAWEKLNETLGLLQSFKCPTVIRITAVRGLNMENI
EEYAKLIEKANPTYVEPKAFMHVGFSRLRLGYEGMPSHREIREFAFKLAQATGYRVVDES
EDSRVVLLSQLDKPIQFSHG
>A0A7C5ZSP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLAPSPLISVLKRQRYHIVGRHSAVKRCRWLYETLIHDRPCYKQKFYGIKSHQCIQMTP
VLYHCTQRCLFCWRAQSGDLQIFWDETKLPPWDSPEEIVEGCINAQLQILSGYKGNPKAN
PQKFKEALIPRHVAISLTGEPTLYEPIGDLIEAFHKRGFTTFLVSNGTVPSALAKISHEP
TQLYISVCAPNEEIYNKVCRPLNPDSWRKLNETLELLNSFKCPTVIRITAVRGLNMGPIS
DYAKIIGKANPTYIEPKAYMHVGFSRLRLGYESMPSHREIREFALQLAKELSYNFVDESE
DSRVVLLSRLKSPIKFSK
>A0A497LE96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MRLLRKQGYHLVGRHSAVKRCHWLYASLTSGRFCYKQKFYGIATHRCIQMTPALYYCTQR
CLFCWRAQTGDIGLRWEETRMPEWDEPELIVEGSIRAQRQILSGYKGNPKTDLKKLEEAL
RPRHAAISLAGEPTLYPALGALIAEYHRRGITTFLVTNGTLPEALAGLEEEPTQLYVSLC
APNERIYKALCRPQLSGLWHKLMETLELLPSLSCRKVIRITLVKGWNLCDEHAYARLIER
AEPDFVEPKAFMWIGFSRYRGLTYENMPKHEEVRAFALKLAEELGYNVLDESMPSRVVLL
SKYDKKWPVGAPRPG
>A0A7C2ZW24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fervidicoccus fontis|TrEMBL
MNVIEKKENVYDILSEVMKKQGYHFVDSHTTLKTCSWTRNALTQRRFCYKCKFYGIESHR
CIQMSPAAFWCWNACVHCWRLRPSDTGLKWNEVKMPDYNDDVKRVVDRLIEEQRKMLSGY
KDHKNVDKKMFEEAMDPKHVAISLTGEPTLYNKLEDLIMEFHRRGMTTFLVTRGVRPDVI
LNLKEKPSQLYISMEAYNKEMYEWLNQPLVPNAWELTMETLKGLPEYGRPTVLRITLMKG
INMDEKAINGFAKIVEIMQPTYIEPKGYMYVGASMLRLSRDNMPTHDEVRKFAEELSKAT
GYPIRSESKPSRIVLLSKLDKPIRFGKGCPEGWNSEY
>A0A5N5XCV4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus leporis|TrEMBL
MAEVSLTEGLLTVWHSYRLSILVAVASIAVILRISRKFQPKSKALTASSIPPSPRSQTPE
KFEEIRPGESGKQVVTEKAAPKPVAGNEPVQKLASGPKRVSGKKPLKVGRRPEPGQGSPV
SFIQPIIFYASLTGTTERYAQVLLEDLQTAARERADPENRGQGLLPPQIHDLSYVDFDDY
FTTAPKPPSTSPGTRYVYCLLVPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKNDAESALKEWSRGLQ
DILFDILENGGLGEGVPGSGDPLESDEEDLDDEASDESNGKRSKRGKGQSVVDLEDIKMG
SDAQAGSGSPIPVDFTTGGKPAAVSQASEKEMVPKTSPTYAALTKQGYTIVGSHSGVKIC
RWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDS
PDLIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDML
HAEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLD
ILREKRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEVKGVTYCGTSTSAGAGL
TMQNVPFYEEIQEFVLALSKELERRGLDYGIAAEHAHSCCVLLASKRFYVNGKWHSRIDY
DRFFQLLEKEKADGTSFRPEDYMRETEEWAWWGNGGFDPNDERVYRKGKKKALQAAAE
>A0A2E9IJN7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVKSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPKELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNTNAWGKFSETLDLLPSLDTRIVCRHTLMKGINMSDQNINEFAALDR
RADPDYIENKGYVFVGHSRENLGVENMPSHEDIMEFSNKIAPLTGRKVLSDSRPSRVALV
GQEITPIPIPEPTMFFPSDLGIAPSVKHLQMAN
>A0A519D6E7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAGRLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLHKIDDDPYELYLESVRGHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRICKPKFDQNAFHKLEETLSILPSLDTRTVCRHTLIKHESLGHYEDYARLDNIA
DPDFIEAKGFIFVGNSRKNLSIDNMPSHAEVMEFSEKLAPMVGREVLSERRESRVALIGR
EMIPITLPEKTMELPKDLGIAKPQNFSLPQA
>A0A2D6BV16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MMDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVV
DQCNLACSYCWREPHMDSLELVDQDPLEMLYESVKAQRRLISGFGGNPKVPKEKFLDAQN
PKHVAISLNGEPTLYSRLSEYMELCHAHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDA
PNKEVFDEICRPKWNAAAWDKFEETIDLLPSLDTRIVCRHTLIKGKNMNPEHIPQYAALD
NRADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRALAPXTXRKLLDXSPPSRVAL
VGKEIVPIPIPEATMHFPEDLGIAESXKHLKXVQ
>A0A2E1NZW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKEVFDQVCRPKWNSGAWDQFEKTIDLMPSLDTRIVCRHTLMKGVNMSDAHIKEFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARKVLSDSRPSRVALV
GTEITPIPLPEPTMFFPEDLGIAPSIKHLPVLS
>F0XFH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Grosmannia clavigera (strain kw1407 / UAMH 11150)|TrEMBL
MGTGIVSILLHNLPYSTEWMRYISIAIFALNISLFSVFMTITMARYILYPEIWAVMIKHP
AQSLFLGCIPMGFATIINMLVFVCARWGNWAIYLAWGLWWVDVAMSCVTSLTIPFIMVRL
HKNQLSNMTAALLLPVVPVIVAAASGGIVAEVLPNDNHAVITLVVSYIIWGLGQAFSFLI
MSIYFLRLQVHDLPPREAIVSVFLPIGPLGQGGFAIQQLGKVAIGLLPVTGAFNGVSIPT
GSSSAMAASAMNGGVVLYMVGILCAFVMWGAALGWLAFAIFAISTTRSFPFNMGWWGFTF
PLGVFTTCTGLMATELSSIFLKVLTEIFSILILCLWAVIAAKTVLLALTGDMFYAPSMAS
TVRASSPVLRDFADGATDIWHHYRIPIILSTFAILVSLRIYFFFTDKGDDHKEGLLVFPK
IYNADDATDKSKVDDRAEKAPATVIAEVSSLGDEKRGNAALVSTEKPASRSATTAAGPRR
IKGELPVGRGRAENGVATARSSIIQSVIFFSSLTGATAKIVQDYATKLGESLESHEKSKG
TTFAAPQVLDLAEVDYDEYFITPPTLTKTADGEGDGSAADFFYLFLIPSYNIDSINDTFL
EHLKETHHDFRIDTAPLTPLIGYSVFGFGDKEGWPTEEEGFCTQAKEIDKWMAKLSGRKR
AFPLGFGDSKSDAMVRLAEWSDGVVEVLDIFSQTGSLGEGVPGSGDPTESDDEEADDEDA
EYEDDEVLFSEDAARSANVNRLKKTGIIDDVEDLGRILQESQEDSKASTTPAPIAVDFTS
YDGTGKGPRRAGRGTKAAPAPTIVREMVAKDSPTYKSLTKQGYAVVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTSWRWVVDPPDLIF
NGVKANHYQKIRTLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHSEDI
SSFLVCNAQHPDQLAALHHVTQLYVSIDAANRDSLRKIDRPLHRDFWERFQRCLEILREK
RFRQRTVFRLTLVKGFNIEDEVRGYADLVEKALPCFIEIKGVTYCGTSTSAGVGLTMANV
PFYHEVCDFVVALDKELRDRGLAYGLAAEHAHSCCVLIASERFRVDGRWHTLIDYDKFFA
LLREKGPDGDFSPEDYMGEATPEWANWGQGGFDPRDQRVDRKGRPIMAN
>A0A365TCU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|halophilic archaeon|TrEMBL
MSESDTVEETSASNRSDDGPKQVGSPDYHSENHTAAQTCGWTANALRGEGKCYKNIFYGI
ESHRCIQMTPVVKCNERCVFCWRDHQGHAYELGDVEWDDPEAVVDASIRLQRKLLSGFGG
NDEVPREVFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTKPDVLAE
CDPTQLYVSVDAADRATFDRTVRAVDDDAWEKLVDTMDVLAEKEETRTVLRTTLVGGENV
HDPDWYAGFYERADPDFVELKAYMHVGHSQDRLDRDAMLDHEDVVAFAEDVQRHMPDHDV
LKQVPASRVALLSTTEDTWVPKLQKDSEFWARDPVTGD
>C3MYP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A7K4NTT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVSDHSTVELCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYESMEMKPENVAEPEEIMTNLMAERRKLIM
GHYGDPNQDKKKLDESLLPSHYAISLSGEPTMYPKLPELIKHLKSLEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYESFLKINRPRYDDSWERWNKTLKMLSTLDTRTVL
RLTLIRGYNDNEKMIPAFASLLRQSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRSFA
NKLVQENNAFTVMDESEISRIVILQNKKRFIDRFIPAYS
>A0A667YLC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
MSLSFYLLSGRPTSPLYIIEFLCSVVSLILLVCFDLLAVQCSNKSVCVFLVATYTDGQPT
ENAEWFCKWLEEASTDFRYGKTYLRGLRYAVFGLGNSVYVGHYNTVGKDVDKWLWMLSGM
RILTRGEGDCNVTKSRNGSVQADFQAWKVKFLSRLQDLAKGEKKSSTGSCKSGSGSCKSR
TKRSQGQSEEEKAALHDNFEAELVESSSDEEESALPEESQSGSVVDVEDLGRIMNSVRKA
KVSLQPTTHLTLMLFFYLCYHSSLQKRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKILQDALEKHQNMIRQFR
GVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRISSFLVTNAQFPQEIR
NLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEKRQRTVYRLTLVKAWN
VEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQY
EIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSGGQRSFSALDYTARTP
GWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A151N5G2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alligator mississippiensis|TrEMBL
MFLSKRGRKSIRYITFGISIWICIQFFAGRTKKQDGKASWKLASLEVTDDVLVNGYATPK
AKEAYVAGVKIFYGSQTGTAKGFAAVLAEAVIALTLPAEIINMREYDPDDCLAEETISKN
VCVFLVATYTEGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLGNSVYIDHYNT
VGKNIDKWLWMLGANRVMTRAEGDCNVAKSKHGSIEADFAAWRARFLLRLQALCKGEKKS
CSGNCKKGKCKSKVKQSKEGSDHEQRVSEQENTEVEELFETTSEEESGAEEDGDANSVID
VEDLGKLMGHMKKAKKEHELDERAGKMDRSLRTIGKKEESEQREMITPALRDALTKQGYR
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKLDQPEMILQEAIENHQSLIKQFRGVPGVKADRFEEAMVAKHCALSLVGEPIM
YPKINRFLKLLHGHHISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFK
DFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGE
SSASNLTMANVPWHEEVVRFVQELAELLPDYEIACEHEHSNCLLIAHQKFKIHGEWYTWI
DYDRFQELVQNYDESGGSKTFTAADYMARTPCWAVFGSRERGFDPLDTRYQRKNKKDISG
C
>A0A4Q4MGN3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria tenuissima|TrEMBL
MALLELLEHLPAELLFIWHQHRLPILLAALVVATVVRLAIYSRDRREKLSVSPAPSSPVP
VEEKPTVQLKPEWLPEYTTLNSSELNVDNHAEDDTRAVAAAAKVKKGPKMVKGRKTPKKL
IAPPTFNHQTDRIQPLVFFQSLSGTTERYAKQFAGVLAEWTRGCDQSKSFLEPQTLDISY
IEHDDYFISPPKGDANVKYFYIILVPTYNIDTVLDVFVESLQETHNDFRIDTAPLSGLVG
YTVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMADVKSEAEERLQDWRV
GVQDALVEIAEGRGLGEGVPGSGDPIESDEEDVAEENGQSTRVDDVEDLGSMVNSSAGPI
PVDFTTYKKSPAKSQSLQAPKEMVPTTSPTYAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDMIFDGIT
TAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLGIMHSNRISTFL
VCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMENVPFYE
EVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRNDRWATRIDFERFFDLYE
GKVEGTRVEDGKVVGWRPEDYVGEETPAWALWGNGGFDPRDARVYRKGKGPKVSEEGGKA
TAAALEF
>C1MIV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Micromonas pusilla (strain CCMP1545)|TrEMBL
SSSARASGGKILFGSQTGTARRLAHKLSASLRARHGLELDVVDARDFEPESLSSTPVAVV
ILSTYEDDDGAAPPENARWLCRWVRESAMDERVGALHLAETKYAVFGCGNREYGDAFHEW
ADKLAARLTAGGIGGGGMRANEDVMKRRAGAGARGTRDRDGDGDGGGKPLAAAAAAAAAA
RASSPSDTSSEDVVVDYDTDAEEGSGDDDGGGDEMSAGSEDDLDMEDIGGGGGGGGDATK
EKREMVTPQLREALTKQGYKILGSHSGVKLCRWTKAMLRGRGGCYKHSFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGREWRWQMDDPLTLVTAAIDGHRGMIKQMKGVPGVVQTR
FDEGMDPRHCALSLVGEPIMYPEIAKFVSLLHERRISTFLVTNAQFPDAIVNLPAITQLY
VSVDAATPETLKAIDRPLFGDYWDRFVGSLKALRTKNQRTVYRLTLVAGWNASDATEYAK
LIDLGKPDFIEIKGMTYCGSTSGASNLTMKNVPYHKDVKAFGESLAAYGLACEHEHSCCI
LLARKDPYLRDGAWHTWIDYEKFQDLAASGKPFTAEDYMLPTPAWSTWGAEEAGFDPGET
RVRKVRNHPGK
>A0A4Q4WL72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. mg162|TrEMBL
MSAAFWESVVDSNRGLTAVLFMVWLYLRLSQRQTKSAGSPKLESGKSLPAELLAEEKVSL
STAKESSSGPRRIKGELRKTDGHKSTVRLDPQRRVQVLVFFSSLTGSTERIAKQFTATLE
ASLLDQTSGSDQAFLKPQLLDLTQIDYDEFFISPPKSAEASQPVDCFYLILLPSYNIDTI
NDNLLEHLKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQAKEVDKWMAKL
TGRKRAYPLGMGDSKRDLKERLAEWTEGVTEVVRQIAKTGHLGDGVPGSGDPVESDDEYV
SGEDDDGEVVVDEPVQPKKTKKSTRDIDDVEDLGRIMKTSRADANDATGRAPIAVDFTTY
SKTSEKPHQTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKM
MRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHGERISSFLVCNAQHPEQ
LAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDILRERRFRQRTVFRLTLV
KGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSGGKDGGLSMANVPFYAEVTAFVE
ALDRRLRERGLGYGIAAEHAHSCCVLLASERFRADGRWHTRIDYDRFFELLEERGPDGEW
TPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A847VAU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum sp|TrEMBL
MPSRPCDPAREALARQGYLFVDPRSTAAVKPCLWARRALGGGEACYKQQFYGIESHRCVQ
MTPTLRCNQRCLFCWRSFEHEPVEEVELSPEALFRALPRLQKQALAGYKVQVPPERFEEA
AHPRQAAISLAGEPTLYSHLPRLIGLMAGDGMTTFLVTNGTRPWVVARCRPFQTYVSLDA
PDGETYRRVCRPADPGSWDLVQESLALLGSRRSAIRVTLVAGLNDHDPAGYGAMVAESAP
TFVEVKGYMHLGYSRKRLTAAHMPPHERVRGFAEQVARHAGFRVADENAASRVVLLERGA
>I3TES7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermogladius calderae (strain DSM 22663 / VKM B-2946 / 1633)|TrEMBL
MLKSIDWGEVKRKREEFWNSSPAYRAIYERMVKQGYHFIGTIGVVKRCHWSKEAVLRNRF
CYKCLWYGIESHRCIQMSPVAAWCWNRCLHCWRIQPEDIGLHWDETRVPVVDDPEVLVEE
SIKVHREIMAGFKGNPKADQKRVEEAMNPKHAAISLTGEPLLYPRLGELIKEYHKRGITT
FLVTHGTRPDVLANLEEEPTQLYISIESWDKKSYEEFNRPLVPRAWELFQETLEIVRSFR
SPTVFRFTIVKGYNDHEEALRSFAKMVERGNPTYIEVKAYMFLGGSRGRLTLANMPEHED
IRRVAQRLSELTGYKVLSESIPSRIVLLSRIDKPIRHGKGCPDGVEHPEKWCPVLTKEYE
ERED
>A0A1J6IZ50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nicotiana attenuata|TrEMBL
MSPSLSSYPTRLAILTLLSATTVYFFYKSRRHLFKRLKSLNPNPKTPKGKIFFISQTGTS
KTLAKNLHSLLNLNGFDFDLVDPKDYEPEDLHKESSVLIIASTWENGKPPSNAGFFIDWL
NESVDDFRVGSLLLSKCKFAIFGVGSGSYGETFNVVARDFSKKLRKLGGVEVLEVGEGDV
DEGNLDEVFGEWSERVIGVLSNLGENGGYMVNGVGDGSEGEVVSEGDDDDDDDEEDDDEF
EENDEESGIVDLEDIAGKGPSRKKGVGDKLVNGKLNGDIVNGEKEMVTPVIRASLVKQGY
KIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGKSWTWKMDDPIEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPI
MYPEINSLVDELHKRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPLF
GDFWERFLDSLKALKEKEQRTVYRLTLVKGWNAEEVDAYFNLFSIGKPDFIEIKGVTYCG
SSATSKLTMENVPWHSDVKEFSEALAKKSNGGYEVACEHVHSCCVLLAKVDKFKIDGQWY
TWIDYEKFHDLVASGEPFTSKDYMAPTPSWAVYGAEEGGFDPEQLRYKKERHHKSSRKEN
GS
>A0A833E5Z8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcales archaeon|TrEMBL
MVRRKKVKIDLEEAKEDPYKVLFAILRKQKYHIVGHHSAVKKCHWLHAALTEGRFCYKCK
FYGIETHRCLQMSPAILWCWNACIHCWRLRPQDIGINWDETKLPVVDDPKFIVEKAIEEQ
RRILSGYKGNPKVNRKLLEEAMNPKHAAISLVGEPLLYPRLSELIQEFHKRGFTTFVVTR
AVRPDVIATLEEEPSQLYVSFEAYNKEMYQKLNMPLVPRAWELTMKTLELIPTLSCPVVM
RITVMKGINMRPEDAKGFAKLVEIAQPTYIEIKAYMHVGTSTKRLPREAMPQHKDVREFA
KMVSEETGYPVVSESIPSRVVLLSRLSKPIRLGNGCPGGWRTPDIGGEESGEYGKYISEV
>A0A3P3YXT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania braziliensis MHOM/BR/75/M2904|TrEMBL
MIIAFLFQLLVSVGLPFVALLLYNHLADSIHARGSVDVDDVNAFSQRVRAELEQLNVPPA
LPEAAPGQAAPPPAPMRSSPAVTAPPPPEAAEILIAYATQSQNSLALAHKLFSLITAQLH
TAPPSTTEDAVCPLVRVMEMREEEDSSASVAAASAAGGRVSRTNVCRVDTLLEQSQYALI
IFIASTYTNGVAPPRSQAFEAMLKDSFEDHRIPRNTLARKRFAVFGLGDIAYGEERFNAF
AKNLHEWCRGLGAPPFVVPPVYTTEAKTQSLFRIFSTALLKWVSRATFHRDGTVTVKKKS
EMGTTGPAAASATGMLSHKAGGITAAPAGETCGSEGASCACQQSTQQQQQRQPCGNGTCP
DGDDNCVCYKTDSIANCVAASKRDDDDDADDDEEEEEVNGENDGMDDVEDLVWDGTEDTD
FDINKDPSELPELLYPKLRQNLEKQGYRLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYNI
NSSQCMEMTPSLACANKCVFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMRG
VPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFCELLHQHHISSFMVTNAQFPEQLRD
LKPVVQLYLSLDAPTPEELKRIDRPLFEDYWERCLSCVKELAKKQQRTVFRLTLVNQYNT
ENVKAYADLVEMGQPDFIEVKGVTYCGTSTSSTLTMKDNVPRHDEVISFCKALCTEMASR
HPHYSTLQMNTEEKGGDDGDDDEVIVIPAEERNRPYHIACEHEHSCCVLIALDKFFFEGH
WHTWIDYERFYHLVESGRTDFTSLDYAAVTPAWATYNSKEKGFDPEQTRVVRKNARPTVV
TASC
>A0A6P5PQX9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mus caroli|TrEMBL
MGPLDVWDFSPLLSLWMNRFYIYMGCALGLTLCICVHIIKKQVTRSQEKSVPGAPDSSLS
PQKKQTHVSGVKIFYGSQTGTAKGFAVILAKAVTSLDLPVAIINLKEYDPDDSLIGEITS
KTVCAFLVATYTDGCPTESAEWFCKWLEESANDFRFGKTYLKGLRYAVFGLGDSAYRSHF
NKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQRGEK
KACGRNCKRGKCESAQHGPGAARPHPQGELHPGDAEEEEPCESSSEDELGTQDYQSLTSV
VDVEDLGNIMNPVKREKREKAHQDGKAAMQRNPEKNEDGEGRAMITPALREALTKQGYQL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMY
PEINRLLKLLHQHGISSFLVTNAQFPEEIRKLTPVTQLYVSVDASTRDGLKKIDRPLFKD
FWQRFLDSLKALSAKQQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYCGES
AASSLTMANVPWHEEVVRFVRELVDLLPDYEVACEHEHSNCLLIGHKKFKIDGEWWTWIN
YSRFQELVLQYEESGGSKTFSSRDYMARTPQWALFGARERGFDPKDTRYQRKNKTKDISG
C
>A0A1V4TNS3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon PtaB.Bin134|TrEMBL
MELNGTALDYMRCLLEGRTEEDMFRYMSHRYKGLDRSTASEHYSRISDQLTRFMQGETSI
LETMGTDRPTIGADDFPAPYRMDLALTYRCQNECAHCYNEPRDMKELDEDRWMKVIARTW
QLGIPHVVFTGGEPTLIPYLGRLIARSESYGQVTGLVTNGRNLSAPGYLKDLVEKGLDHV
QITVISHREDVHDRLSGAPGAWRETVEGLRAALKEDLYVSTNTTIMSANQDDVLETMRFL
IGLGVRNIAFNSVIRSGKGKETEGVAYPVLQDLLTKLSLLAEEAGVHMTWYTPTPSTSAW
ASSSAPPAPSTWRWNRTARSSPARATTSPWETY
>A0A523B5X1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nezhaarchaeota archaeon WYZ-LMO8|TrEMBL
MIRNLGEHKMLSQSTALTIMDLLRQQKYQLIGSRKTAAVKKCYWLHMALTSNRFCYKNWY
GIESHRCIQMTPTLACPNSCLHCWRIERGDPNTSPWKEEDFITHDDEKAIFEQAIRAQFR
ILSGYKSNPKVIKERYVEALHPRHFAISLAGEPTLYNRLGEFIELCRSKGFTTFLVTNGM
YPEKLASLIDKGRPSQLYISVNASSDEKFMALSRCSLIDGWQRLMRSLRLLREFKCPTVI
RITVIRGVNDHENDIESFAKLISLAEPWYVEVKGFMYLGYSRFRLELSNMPKHRDVLSFA
EKLSKVCGYNLVAESLASRVALLSRISEPVKVHP
>Q6BVA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)|TrEMBL
MSLGNTVLALCCMLYLLSGGRWSIVIAAGTLSLMYSKNKQSSQVISKSISEDKAVDKESS
KPSPIYAVDFTSTSFTPESTTNIPENKSRSVKPISSIRSRGRRSPKIIKANKPITNNSEP
ALTRSTVNLLDSQIYIFYTTLTGSSQRVAKALYEKLENLPNLINKPKLLSLDDDVDDLEE
YFLKTPESEKNKSIYLLVLPSYETDSPIDYFLEHLKETYQDFRVDKYPMRSLLGFAVLGL
GDSESWAGDKFCYQAKLADRWMGKLGGRRLYPVGEVCMKYDGEPKTNTWIQNFASLLADD
EPFYLDANDEIDDSDYENDDDDEDSNTLVDVEDMGDIIKKQGTKGLSSQTEVKQMVAKDS
PTYKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSN
KCVFCWRHGTNPVAKSNWRWELDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFDEAFKV
KHCALSLVGEPIFYPYINEFVGMLHEQQISSFLVCNAQHPDQLAKLNRVTQLYVSIDAPT
KTDLKKVDRPLNSDFWDRLMSCLDILRTTQSHQRTVFRLTLVKGFNMNDISSYADMVIRA
QPSQIEIKGATFCGSSNSNGNPLTMQNIPFYEECKQFVISLSEDLKSRGYDYEIAAEHAH
SCCILMAHKRFYRNGKWHTHIDYPRFFELLESGEEFNDVDYIKETPEWAVWGSEEAGFNP
VDTKFDRKAEKMKNRLEREEKAKRVLEQQKVH
>C4YAE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clavispora lusitaniae (strain ATCC 42720)|TrEMBL
MDSGPLILAVCCALYSLSGGRWTFVAAAIAGYFFSTRKAPVVPEFSASAEQKPSPIYEVD
FTHYTPTEKSTFPLKTARRARKTRSPKVFRGSKPPAKNGDASLTTALKLVESPIYIFYTT
LTGSSERIAKSLHAKLSSLDGLLHQPLLRSLDDDVDDLEEYFLKTPKNSQPNIYLLVLPS
YETDSPIDYFIEHLTDTFQDFRVDKYPLRALAGFAVLGLGDSESWGGAKFCYQARLADKW
LGKLGARRLFPVGEICMKTEGDPKAQDWINGFSELLADDTPFYIDENDAADDSDAENEEI
DADDVVDVEDMGSIIKSGSLELETKEMVAQDSPTFRSLTKQGYTVVGSHSGVKICRWTKS
AMRGRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEKV
LEGALEGHYKKIKQMRGVPGIQMDRFQEAFTVRHCALSLVGEPIFYPHINEFVGMLHERH
ISSFLVCNAQHPEPLARLAKVTQLYVSIDAPTKSDLKKVDRPLNADFWERLMACLDILRT
TQSHQRTVFRLTLVKGFNMGDIESYADMVERAQPSQIEVKGATFCGSSAGNGNPLTMQNI
PFYEECREFVQKLTAELQRRGSKYEIAAEHAHSCCILIAHSKFKINDKWHTHIDYPRFFE
LLESGEDFCDMDYVKETPSWAIWGSPEAGFNPEDTRYDRKAEKLRKKKEREGTA
>A0A849PU01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MRQKKSSKTQSLPTISWSLKSNRDTVIPMLPENLRLLLEKQKYRIVGNHSAVKICTWTKK
SIKGEGVCYKEKFYGIKSHRCLQMTPAVAWCPNKCVFCWRATDRTLGPEIKESLDTPEDI
LEGSIAAQRNLLTGLKGFEGTDIKKWKEAQDPNQIAISLTGEPTAYPLISDFIDLCNRRK
MTTFLVTNGQFPERLENIAKPYQLYLSLDAPTKEMYRKIDMPMFKDYWERFTKTVDIMSS
FNSRKTVRLTLVKGINMSHIKDYAKMIEKINPNFVEVKAYMHVGFSKYRLPIEAMPLHDE
VKEFSEKLKTELSYKIKDESRPSRVVLLER
>A0A1S3GID6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dipodomys ordii|TrEMBL
MDSSVDVWDLTSPLLSLWINRFYIYLGFALGISLWICVQIILKKQAKNSQEKCIPKGTQD
LMMKGSISLQKKQVFVSGVKIFYGSQTGTAKATSKGVCVFLLATYTDGQPTESAQWFCKW
LQEAAHDFRYGKTYLEGMRYAVFGLGNSAYLSHFNKVGRSVDKWLWMLGAQRVLARGEGD
CDVVKSKHGSIEADFRAWKAKFTSRLQALRKGEKKPCSGNCKRGKCKSKQQGPEQTELES
HLHEGLHHRDTEEEEPCESSSEEEDGSNGHQSLNSVVDVEDLGKIMDHMKKEKREKDQQE
EKMSLLRTGKSEDGDGRAMITPALRDALTKQGYQLIGSHSGVKLCRWTKAMLRGRGGCYK
HTFYGIESHRCMELTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIESHQRM
IRQFKGVPGVQAERFQEGLEVRHCALSLVGEPIMYPEINAFLELLHQCKISSFLVTNAQF
PKEIRNLKPVTQLYVSVDASTKDSLRKIDRPLFKDFWQRFLDSLKALAAKEQRTVYRLTL
VKSWNVDELQAYARLVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVQELVE
LIPDYELACEHEHSNCLLIAHRKFKIDGEWWTWIDYGRFQELIQRYEGSGGSETFGAKDY
MARTPFWALFGAQERGFDPRDTRHQRKSRSKDVSGC
>A0A662J5B9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MYLSPQVKSLLVKQRYHLVGRHEHAAVKKCHWLHKALTEDKLCYKSWYGIQSHRCVQFTP
MLSCPNACLHCWRIERSDPGVSWDELRLPPIDKPETLIEGALKEQRRIVSGYKSNPKVDR
KRFEEALHPRHFAISLAGEPTLYPYIDDLLGLLRSKGFTSFLVTNGLYPEVLSSLSNEPS
QLYVSINAPNETLYRKVCRPSMSDAWQRLNETLSLLSTFKCPTALRLTLIKGVNDVDIEG
YASLIEKANSHYVEVKAYMYLGFSRYRLKLGNMPRHSEVVRFAHLLSQHIGYEVLEDSLH
SRVVLLSRLPKPIEVA
>A0A6I9TKN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sesamum indicum|TrEMBL
MYPSLPPTRLTLLTLLSATATFYFLYKSRHRHSRLLTRLCQAVTGPGLRCGNPASYKRGK
LLFLSQTDTSKNLAQRLHALLTLNDLPFDLVDPKDYEPEDLCKESLVLIVASTWENGGAP
ENGVFLVNWLTESADDFRVGALVLKECKYAVFGVGSRSYGETYNAVARGVSVKLRKLGAS
ELVELGEGDVDEADLDEVFDLWSKKVVGVLKDKLGENGQHFENYGVECESEGEGEFSEED
DDEDAENGGDSAIVDLEDIAGKGPSRRSVVATKANGKVNGEVLNGEKEMVTPVLRANLEK
QGYKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGKSWKWKMDDPLVIVDTAIELHTKMIRQMKGVPGVKAERLSEGLSPRHCALSLVG
EPIMYPEINALVDELHRRRISTFLVTNAQFPERIKMLKPITQLYVSVDAATKDSLKAIDR
PLFGDFWERFIDSLKSLREKQQRTVYRLTLVKGWNTEDVDAYSSLFDVGSPDFIEIKGVT
YCGSSATSKLTMENVPWHSDVKEFSEALAQKSNGMYEVACEHVHSCCVLLAKVDKFKVNG
QWYTWIDYDKFHDLVSAGEPFTSKDYMAPTPSWAVYGAEEGGFDPLQSRFRKERHHKSSR
>A0A662IRW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MLAQSTTSAIISLLRQQKYQLIGNRKTAAVKKCHWLHAALTSNRFCYKNWYGIESHRCIQ
MTPTLACPNSCLHCWRIERGDPSTPSWREDEFMTYDDEKTIFEQAIKAQFRILSGYKSNP
KVIKERYVEALHPKHFAISLAGEPTLYDKLGDFIELCRSKGFTTFLVTNGMYPERLVKLL
EKGQPSQLYVSVNASSEDKLKALSRSSLADCWQRLLRSLELLKSFTCPTVIRITLIKGIN
DHEGDLKGFAKLISMAEPWYVEIKGYMYLGYSRFRLKLENMPKHSHILEFARRLSRITGY
QLIADSLSSRVALLSRIGEPVKVKP
>A0A2V2UPK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi|TrEMBL
MTESISEALWWVLLGALIPLVTLTLTTLLDRWVSRRRKRQMEVARAQAAKEGKTTWMEPN
VHNSTGKTNGNGSTIHDAVKGSKGRVDVKKILIAYATQSNTACKLAHKLFSTLSTTLHES
RDEMQGGSSSCVCSEGSSSCCATSHTARHLPELKVLQLTEEGRQCGVEHLLESQAYGLVI
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKFAIFGLGDIAYGEKHFNRFA
KNLYMWCKGLGATFVVPPVYASEANTIPLFNVFTASLVKWVGRVTFTADGVTILKRQQKQ
LKEKKEKGQIKLCNDVELQGNATYNSEEDEEEEEREEEDEETGRKKRNHNSEGDVEDVVT
DDEDEGEDVNGQSGSVDHAVQALSSEPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTK
AMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRTFRWKVDPPQLL
LAEGIAGHQKMMKQMRGVPGVTPERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHEQG
ISSFMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRR
KPQRTVFSSDAC
>A0A0Q1AP27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. SDB|TrEMBL
MERFPPQISERLKRQGYHMVAHGAVKPCLWLRRSIRGGDQCYKNHFYGIASHRCVQMTPT
LLCNHRCLHCWRPIDDMPNSSGDWIEPAELLDGILEEQQRLISGYGGAPETTDLSRLEEA
KHPAHVAVSLMGEPTLYPMIKELVDEIKSRDMTAFLVTNGTMPDVIGEVRPTQLYLSLNA
PDEETYLKVSNPQANLWSRFLESLDRIRESPSRTVMRLTLARNLNMIDPQGYAKLIEIAE
PDFVELKAYMHLGSSRNRLERDSMPTHEEVMEFAGALSEILGYRLQNHVPLSRVALLSRG
SAQERIEL
>A0A5E4I5X2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MIPVISLRSMLLGTTNPKIPETLKLLLRRQNYGLVGNHSAAKICEWTKKSLRNEGVCYKE
KFYGKLHGIRSHTCLQMTPSAYFCPNRCIYCWRATDKTLANTMDGFEADEPEEIVEKSIE
AQRLLLSGFKGYKNVNMKKWKEAQDPKNAAISLTGEPTAYPKISGLINEFARRKMSTFLV
TNGQFPEQLENIEEPSQLYLSLDAPTKEIYKTADIPQFSDFWERFNRTVELMPSFSCKKA
VRLTIVKGKNDSHPKEYAELIKKAGADFVEIKAYMWIGFSQRRLPIEAMPSFLEVKDFAL
KLNEFLGYEYKDEDERSRVVLLAKSI
>A0A2R7Y999|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zestosphaera tikiterensis|TrEMBL
MHSAVKKCLWVHNALTQGRYCYKCKFYGIESHRCIQFTPSTLWCWNACLHCWRVRPQDMG
LRDEDLMKLPYVDDPSVLADQAIEEHRRTVSGYRNVAPKELWLEAMDPKHVAISLTGEPT
LYPRLGELIREFHKRGLTTFLVTRGIRPEVLASLEEEPTQLYISLEAWNKDMYTYFNKPL
VSKGWEKTVKTLEMLPSFSSPTVIRITLVKGFNMSDKDVEGFAKLIDLASPTYVEPKAYM
HVGGSTGRLSRENMPSMQEVMNFAYKLAEATGYKLASYSRPSRVALLTKLSGPVIRYGKG
CPKAWETEDVGDEFSGEYGAEEF
>A0A7S1KRP4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Percolomonas cosmopolitus|TrEMBL
MDLTTFVIICLLLGLVYHGILQYQKQKARADVIQYWLDEHDKKQNEGSGDINTGKQARTT
GKRAKMRIQILFSSQRGTSKTYATKLFQQLKKIAKSVTLRNMNKFDPERITQQGHTDLLI
IFAPTYDNGLPSDDGRAFYEWLDDLSLDFRVHKNMLHHLNYAIMGLGDSAFGPERFCQVA
KKMERCLKKLSATSLVPTELGDNGAGNDVNKQFNAFRERLINAISASPDTHQSKSRDDHP
TDISKAVEILSDSDDEGEPMLDIEDMAPTDETKHSADSSSTDVAQISTEDVPEMLTPLLR
KSLEKQGYKLFGSHSGVKLCRWTKAMLRGRGGCYKHTAYGITSYRCMEMTPSLACASKCV
FCWRHHSNPVARSWKWKVDEPEFLIQNAVENHVKMINSMRGVPGVQKERFEEAFVPKHCA
LSLVGEPIIYPHIGKFLNLLHEKNISSFLVTNAQFPEQMENVDKVTQLYISVDASNPEAL
KKIDRPIFEDYWERFLECIDIMKRKKMRTVFRLTLVKSWNMNEMREYAELIKRGEPMFIE
IKGVTYCGNSKSSDLTMKNVPFHEEVKDFAFKLCQVEGMEDYEPACIHEHSCFVLIAHKN
FRINGEWHTWIDYERFHELVHSGEDFDAFDYVAKTPEWCLIESEEQGFDPAEERVYRKGK
KKGKKEPVQQEYSAGGC
>A0A1B5L057|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ustilaginoidea virens|TrEMBL
MNLKLAQYDRNAIRMDNVMNRQIGHLPRKVVERVAPYIDSGDIFLEAQLTGFKGTYDCPV
RLYFYGPSDSSDRSRIENKLKSDKLVKSTELKRTRREAETRRAALGLKAGGLTYGLGTNG
YEDPEISLEDILKHSQSVEFRNGKDVIKTLAMDELYLSQMPYCEQPSALKATLLPYQLQG
LAWMISKENPILPTKDADNLVQLWKYDGKGYWNVATDFISKSPPKLFSGGILADEMGLGK
TLQVISLILSGGVGTTLIVAPVSVMSNWKQQIERHVKPECLPNVLIYHGDKKMSPQDLMK
FDVVITSYGKLARERDANVPQVLLSTAMQWRRVVLDEGHTIRNARTKVALAASMIKARSR
WVLTGTPIGPVITNCKHVFCRACIVKAIEMQHKCPMCRNTLSEDCLLEPAVEGQFDGNFD
TETQSSKTEAILQIVRATLKKPGSKVVIFSQWTSFLNIVGRQLDISGLKWCRIDGSMGTE
QRDRAVQALDNNADTRVMLASLAVCSVGLNLVSADTVILSDSSDIVGVWHEYRTPLILSA
LVFLLAVRVYIRKTTEPNPSETIRNAAEKKLASSSALVAREWNAIVAEKRGAKPDGPRRI
KGGVSGKPIVQEKEHRHDRDRPVKVLVFFSSVTTKTEKIAQQYLTRLQSSNADMSKAAER
QLLTPELHDLADVDFEDFFVNPAKSPENAQLFYLFLIPSYNIDTINDTLLQHLEETHHDF
RIDTAPLAPLLGYSVFGFGDKEGWPDEAEGYCFQAKELDKWMSKLTSGKRAYPVGMGDMK
SDHVERFEEWARGVQDAIASVARNGSLGEGAPGSGDALESDVEDNAEEEYGEAAARQEGK
TSAAAEEPSRPLDDMEDLGRMLQTSSSKEIAAGKKAPLAVDFTSYASSAKKRPQPAPVVK
EMVAKDSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETT
PSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIFKGVKENHYKKIKMMRGVPGVRAERY
AEALRIRHCALSLVGEPIFYPYINEFLAMLHSERISSFLVCNAQHPDQLAALKAVTQLYV
SIDAADKDSLRKIDRPLHRDFWERFQRCLDILRAKRFRHRTVFRLTLVKGFNVDDQVEGY
ARLVERGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCDFVRALEKRLKDKGLRYG
IAAEHAHSCCILLASERFFVRGKWHTHIDYQRFFELLEERGPDGDWTPEDYMGEPTPEWA
LWGNGGFDPRDDRVDRKGNRIENVVVREAPPREI
>A0A8B8RE14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Camelus ferus|TrEMBL
MDPSLNTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQDKKSQEKTVPKASQD
LMTTGCQSPPKKEIFVSGVKIFYGSQTGTAKKFATILAEAVTSLELPVAITDLKEYDPDD
HLVEEVTSKNVCAFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMKYAVFGLG
NSAYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVVKSKHGSIEADFRAWKAKFISRL
QALRKGEKKSCGGNCKKGKCESNQRGSEGTEPGPHPPDRVHQRDAEEEEPVGSTSEEESG
SEDHQSLNSVIDVEDLGKIMDHVKKEKREKEQQEGETSAFRSTAKSDASERRAMISPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFLKLLHECRISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVARFVCELVELIPDYEIACEHEHSNCLLIAHKKR
>A0A8C6NSI5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
MTCSLSRVSSALSESVLSDFINKRFRHNLTAEIEALGITAEVVDMKNYDPDDRLADECVG
RSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGLRYAVFGLGNSVYVGHY
NTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAWKVNLLSRLQALAKGEK
KSCSGKCKGGSSCKDKNEEVTSQDASAEKLNRQQFLCEDESGLADERTSGSVVDVEDLGN
IMTSAKKAKVRLAENDEGQMVKMNGGKKTEDDGERREMITPALREALTKQGYKLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRW
KMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCALSLVGEPIMYPEINTF
IRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFL
DSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEVKGVTYCGESAASSLT
MANVPWHQEVVAFVQQLADMLPRYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQE
LVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A1F5CTP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon RBG_16_48_13|TrEMBL
MSILPAELRTTLRSQKYQLVGHHSAVKKCRWLHMKLTENRACYKQKFYGIQTHRCLQMTP
TVAHCTMQCQFCWRVQPSDLKISWVETKLPLMDDPETIVDESILAHRKILSGYKSHTNLD
MKIYNEALNPKHAAISLDGEPTLYPKLSSLLEIFHKRGFTTFLVTNGTIPKALEKIKAPS
QLYVSVYGPDENIFKEVCRPQLPNLWPNLIRTLDLLPSFSCPTVLRLTLVRGLNMRDPKG
FANLIKRANPTYVEPKGYVYVGSSRRRLKFENMPTHEEIKDFSKDLANETGYNLIDECRE
SKVILMSRLEKPIKLTAP
>A0A6G1HL16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichodelitschia bisporula|TrEMBL
MPHLGIFELPDELLDLWHQYRIPIILSTFGLLTAVRLGLHFKYGRPKAMVSSMPGSPRPS
LVDGVEKPLVDIKIRPLESGEKAVVYTEKPKPVKSARKHSPKRVTGKKVRRPKGTGQMLF
DPEVDSIRPLIFYSSLAGTTEKAAGKLASDINHWIRDRQTAGDSKLLETQSHDLSYVEYD
DFFITAPKDEPNTKYFYIVIIPSYDIDTVLNTFLEHLQETHHDFRIDTAPLSGLVGYTVF
GFGDREGWSTEEEGFCSQAIEVDKWLAKLTGRKRAFPLGMGDVKTDGAERLGEWLSGIQD
ALVDIAAGKGLGEGVAGSGNAVASDEEEEEPNSKASLDDVEDLGKSYRGPVEKDSEEWAP
MAIDFTTFNKPASAPAPAPAPLKEMVPKSSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFTFYGIKSHLCMESTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEVIFEG
VKEGHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFTAMLHKEHISS
FLVCNAQHPDQLATLNHVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILREKRF
EQRTVFRLTLVKGFNIDEEVEGYADLVAKGLPCFVEVKGVTYCGTSTSSAAGLTMQNVPF
YAEVQAFVVALDAALARRGLSYGIAAEHAHSCCVLLASTRFRRDGKWCTRIDYGRFFELL
ESGKPFGPDDYVGDETPEWALWGNGGFDPRDERVDRKGKKKIVEI
>J8PH58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644)|TrEMBL
MNGFTLAGAVSVGTLTAAYLYFGGRFSIALVILVGYGIYCNEASGQVNGEVSSNPEKKKS
CCSDKKSAEGGKTGGCCSDKKKNGGSGGGCCSSKGGKSKKVGGCCSTKDGKKGGCCSSKK
TISNDENVAPKVEETKNFPVTVDFTEVFKKPTKKRSGTPKVFSKNGLSKSKVGKKLSVSK
KIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKTVYDKLTELDELSNKPKLLN
LDDLSDFDEYFVDVPVDNALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLVG
YTVLGLGDLESWPEKFCYQAKRADHWISRLGGRRVFPLGEVCMKTGGDTKIDEWTSLLTE
TLKDDEPIIYEYDENADSEEEKGEDDDGSDELGDVEDIGGKDNNGKFSSADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIADRFAKAFKV
RHCALSLVGEPILYPHINKFIQLLHQEGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKSVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPCFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTAELQRRGLHYEMAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNMENQGNSKIKAAPLPPIPA
>A0A1Y2LKM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Epicoccum nigrum|TrEMBL
MAMSNTAEKLFTELLAIWHTHRASLLVVAVSLALLARFTTQFRNAREKVSVSPAPASPID
EKKTVQLRPEWLPENTTIVTPALNVDNHAEDDASAVVALPKRKRTPKTVKGKKTPKKAPK
PAIDYNHTTDKIQPLIFFQSVTGTTERRAKQVVELLTAWTTGCDQSASFLKPQLLDLSDI
DYDDYFISAPKAEENTKFFYLILAPTYNIDTLLDAFIENLSETHNDFRIDTASLGGLVGY
SVFGFGDKEGWPTEEEGFCTQAKQVDKWMARLTGRKRAYPLGMGDVKTDAEDRLTEWRLG
VQEALVEIAEGRGLGEGVLGSGDAMESDEEDVDDGDSGEDTPRVDDVEDLGGMANTNTTT
TPIPVDFTTYKGKAKVNPNAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALR
GRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDVIFDGI
TAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLQIMHANRISTF
LVCNAQHPAQLASLVPVTQLYVSIDASNKESLRKVDRPLHRDYWERFCACLDILRARRFE
QRTVFRLTLVKGFNMEEEVKGYADLVERALPCFVEVKGVTYCGTSAAGSAGLTMQNVPFY
EEVAEFVTLLETELNSRGLYYGIGAEHAHSCCILLADSNRFKREGRWATRIDFERFFDLY
EGKVEGTRMENGKVVGWKPEDYIGPDTPEWALWGNKGFDPRDQRVDRKGRPKTEEEAKAS
PKERAAARQAALEF
>A0A842W8F5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MVSANTQKDLEKQGYRFTGRHSAMKVCDWCRKSLRGDEICYKGDFYGIQSWRCIQMTPVF
ACTHRCVFCWRNIEETDEINQIEDTPEQIIDNCIEEHKRYLYGFGGNENRNKERYAQIER
PLHFAVSLTGEPTLYPQLPELVDEIKRRKMTVFLVTNGTQPEMLKKLLNHQPTQLYLTLP
APNKEIYEKTCNPLISKGWERINESLSLINKFNRSCLRLTLVKGVNMSRPEQYAELIKKA
NPLFVELKAYMWVGHSRNRLEIQNMPYHKDIKQFAERIAAELNWKIIDEKPESRVVLLMK
QDIPNRILKF
>W7KID8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aramenus sulfurataquae|TrEMBL
MNTLMETPKFRIDTLSRIVDEMEKEKYHIIGSHSAYKKCYWTHKALTAHRYCYKGKFYGI
ESHRCVQMTPVAAWCWFRCIHCWRLEPEDIGLEWDETKMPVSDDPEYIAERSIEEHVKAV
SGYYGREGVDKELVKAASRPAHVAISLTGEPTLYERLGELIKEYHKRGMTTFLVTSGVRP
DILASLEEEPTQLFVSLQAPNERKHKLINRPIVANSWNLVMETLRMMPSFSSPTVIRMTM
IKGFNMSEDDAREFAKLIEISMPTYIEVKAYMHVGPSTYRLSRDAMPRHREIREFAELLA
KYTGYKILSEHVPSRIVLLSRLDRPIQIGNAWTQKWDWRAKDKEDDIHGEYEEAELGCTE
GT
>A0A5P1ELJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Asparagus officinalis|TrEMBL
MTAASPSSLSAHLALVTVLSFSSLFFFYKSRRLRTQRLSSPRNPNPNPNPNPRGKLFFAS
QTGTSKTLAARLLDLLQSNSIPFDLVDPKTYEPEDLPKETLVLFVASTWEDGKPPSNAQF
LAQWLAESAEDFRVGSLILSRCKFAVFGVGSRAYDERFNKVGKDLSLWMRALGAAELVPV
AEGDVDGGDLDVRFGLWSERVVKVLKGEGGDDGVESDVFDVLEEEVEDEDDDYDDEEDEE
VESEAVDMEDIAGKAPSKKSGSGLANGDNGAREKSSENGFREMVTPVVRASLQKQGYKII
GSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
KSWRWKMDDPLVIVNAAIDQHTKMIKQMKGVPGVTQERLSEGLSPRHCALSLVGEPIMYP
EINSLVDELHRRHISTFLVTNAQFPEKIKALRPITQLYVSVDAATKESLKAIDRPLFGDF
WERFIPVKLLCNPLSCRCKHPIVIVVEMDRILRPGGWAILREKLEILNPLESIFRSLNWD
IRMTFAKDKEGIILVDAVGNSDNHELARRRRRLWSRVWSETEAGSRDLGRRAGPKEWLRG
QKKKAARYVLDPIVASQRSLRSAYLLMTSEAVDGVSEEIKRLLNSARRDCVPQERSSVVA
FQARSGVEVCTFKLIVKNAASLLDDSDPVKLEAEDRLDVLIRSFSALGTTVDKSDFRLNA
DREKVKEGLTDSIYALGKFGQAIKDCLGV
>A0A668UY82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis aureus|TrEMBL
MWLWHSRLYLYSAAALVFGLWFLLKKKSVSKDSSKEENDKADKAPKKNDRETKEVHVSGV
KIFYGSQTGTAKGFANELSEEVKALGLPAEVIDMKDYDPDDQLADEVSQSKSVCVFLVAT
YTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKW
LWMLSGRRIMTRGEGDCNVVKSLNGSIQADFLAWKVKFLNRLKTLAKGEKKSCSGKCKTE
GSCKNKRKERQEEEKKTSPQNNSSEVRAGNKDINVYMAVDHNRLKVLFLPQSKEESQRDG
QMVKLSKLNGVQKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEK
HQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVT
NAQFPQEIRYNLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTV
YRLTLVKSWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFV
QQLADMLPEYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYDESGGQQTF
SALDYVAKTPSWALFGAQEQGFDPAETRFQRRNKSKDISGC
>A0A832CEP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus sp|TrEMBL
MKQLSELKGYCIVGRHSAVKTCLWLKKSLKDLGVCYKQKFYGIQSHRCLQMTPALLCNQF
CVHCWRPLELLKDFKGWDEPEFIVEESIKAQRKLLSGFYGTEGVNREKLKEAEKPNQVAI
SLVGEPTLYPRLPELVECYKKRGFTTFLVTNGTNPRMIELVEPTQLYVSLTAFDEQSHLE
MNRPAKSLWNRILESLEAMRNSKSRKVIRLTLIKGLNMHEKALEKFDKLIRIAEPDFVEA
KAYMFLGYSRLRLNFENMPSHEDIVEFSKKLEKLGYRIVDESKESRVCLLSL
>A0A7L0JMM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chauna torquata|TrEMBL
LGVSMDTWNFSYTCLVSLWLHRFYIYSIIAFGISLWIVVQFFASKNKKKGEKFSGDLSSS
EAVADKLVNGYAALQARKVYVAGAKIFYGSQTGTAKRFAKSLAEAVISLNMPVEVINMGD
YDPEDCLVEETTSRNICVFLVATYTEGQPTESAAWFCKWLEETANDFRFGKMYLKGLRYA
VFGLGNSVYVDHYNTVGRNTDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKTK
FLSCLQALCRGERKPCSGKCRKGKCKSQGKKSKESSDHEHGASEYETSEAEELVETSSEE
EAAEEAGGTNSVIDVEDLGNVMSHMKKAKKSCIEMEMLNNFVYHLACFVDQLLEVKIDGL
IYFLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGRVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINRFLRLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVHFVQELAELIPDYEIACEHEHSNCLLIAHKKF
KIDGEWCTWINYERFQELVREHERSRGSKTFTAADYAARTPRWALFGSSERGFDPLDVRY
QRKNKAKDISGC
>A0A397A4V8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
DNLEHEHVLISILSTWTGGVPPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLGNSE
YDEHYGKASKALSKHLSSLGASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGALRS
PAASSSSSPSVKPKQQPAGWKSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIVLEL
DQGDDSDDEDNRPKKQDSGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYKIIG
THSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGR
EWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMYPH
INEFCRELHAREISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKDFW
ERFLSCLTQLKAKGQRTVYRMTLVKEHNMKELDNYVELIHLGEPDLIEIKAVTYCGKSDA
SDLTMQNVPYHQEVRDFCELLCAKLGGGYELATEHAHSNCVLVAKTKFKIDGHWHTWIDY
DKFHTLIQAYVCSCVDGWMVVVCIVLSSEISYYKDGTPFTTMDYIAPTPAWAVYNAPEAG
FDPIETRFRRTKEGKVVEIEYTATDSGCG
>A0A167UAB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cordyceps fumosorosea (strain ARSEF 2679)|TrEMBL
MDHLGGGYEQSALFNANGLLDVWHTNRTPIILLALGGLLLFRLYIHVYEEKPDLKTIPKL
YEKAPTQKLENVPQRQVQEKTAVKPAGPRRIKGGVVKKPETSEEPIDPTKPVKILVFFSS
ITTKTEKIGRDYIAQLEKSVQQLAAETKHPVLAPELLDLTEIDFDDYFIAPPKSDDGAQF
LYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREGWPDESEGY
CFQAKELDKWMAKLTGRKRAYPVGMGDMKSDHAKRFTEWASGVEEVFAQVIRTGHLGQGV
PGSGAAVESDDEAEEEDYDDGEVVFDNEKPSKRENGNKSGSLDDVEDLGRMIRSQGGDAN
PKAPIAVDFTTYNNSKGTAQNKAKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWTKSA
LRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFD
GVKENHYKKIKMMRGVPGVRADRFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKERIS
SFLVCNAQHPDQLADLKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNRCLDILREKR
FRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLSMSNVP
FYWEVCDFVRALDKRLQEKGLAYGIAAEHAHSCCVLLASERFHVDGRWHTHIDYDRFFEL
LEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVIREAPE
>A0A4U6SV23|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Setaria viridis|TrEMBL
MMMISPITYLRPSLPESRAQRRVSKTPQNPRAESAPPTRTAAAMPPFPTATTASATSHLA
LLVLLSSSSLFFLYKSIRLRRKPSPASGPARTTTPTLLYASVTGTSKTLATRLSDRLTAN
AGVPILATDASSFEPDDLPSVPLLLLVVPTHDGGAPPPSAAFLARWLEESTADFRAGALL
LSGLRFAVFGVGSRVYGETFNAASRNFSRWLRALGAVEVVPLGEGDVDGGELEAVFEDWS
GKVLRVVKGEELNEGVLGESDGLDELELEGEESDDDDEEETVAVEIDMEDIAGKAPARQN
GKVEGSLANGGQNGVKEMVTPIIRTSLEKQGYKILGSHSGVKICRWTKSQLRGRGGCYKH
SFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDNPLDIANAAIDQHTKMI
KQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVDELHRRHISTFLVTNAQFP
EKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSLHEKDQRTVYRLTLV
KGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKEFSEVLASK
SGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELVTSGKPFKSQDYMALTP
SWAVYGAEEGGFDPDQSRFKKERRHGTAALKG
>A0A3P9DEF0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Maylandia zebra|TrEMBL
MCFLPPVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKKKSVSKDASKEKNDKV
DKAAKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKSLGLPAEVIDMKDYDPDD
QLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLG
NSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSIQADFLTWKVKFLNRL
KTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKASPQNNSSEDDLVESSSDEDESGLPD
EKKTVLDVEDLGNIMNSVKKAKSKEESQRDGQMVKLSKLNGVQKIEDEGERREMITPALR
EALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCA
LSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTQDSL
KKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFIE
VKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHTKVI
TPSKPPKVCTKLHNVAHLKFLTTKEYLIHSYYLFGVSSH
>C7NTJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2)|TrEMBL
MSDDTRQVTDPDYHSEGHTAAQTCGWTDNALRGEGRCYKYAFYGIRSHQCIQMTPVVRCN
ERCVFCWRDHAGHTYELDDVEWDDPEAVVDASIDLQRKLLSGYGGNDDVPRERFEEAMEP
RHVAISLDGEPTLYPHLPELIEAFHDRGITTFLVSNGTDPEMLAECDPTQLYVSVDAADR
RTFDDVVKAVEDDAWDRLIDTLDVLAAKDDTRTVLRTTLIDGYNMARPAWYAAVADRADV
DFYELKAYMHVGHSRGRLDRSSMPDHDDVLSFTEAVGEFLPAHDVIKESADSRVAMLARE
EDTWVEKLAPDSDFWEEGTTTGWTPKGGRS
>A0A0C7MXQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea lanzarotensis|TrEMBL
MDFLKDLDDHLLILSVAATYVLSGGRFTFGLAALVIYGLVKYDAARNEKQAEIPDSERIE
NSEDETKKKTCCGGKGGGCCSSKSGGKKGGCCGGNCSSKNKTSEKIEDNIKDTPQNDTQV
EELAIDFTEAFKPAKKSKKVRKIVKASKPGSKSQSEFFKKALTVSNETLISSQVYVFYSS
LQGAAERSAKIVTSVLSDIKGLKHVPKLMNLDELSDFDDYFVNVPCSNALYVMVLPSYET
DSPLDFFLQSMEENVNDFRIDRLSLRKLVGYCVLGIGDSESWPEKFCYQARQADLLLAKQ
GGRRVFPVGEVCMKFGGDPSVMEWAKLLANTLQDDEPILYEYDESLETENAEEPNDELTK
ESLIDLEDVGASSELQDVNEIKQMVAKNSPTFKNLTKQGYTVVGSHSGVKICRWTKNDLR
GRGSCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDDPEYILEDA
LKGHYSKIKQMRGVPGVIAERFAKAFEVRHCALSLVGEPIMYPFISKFVKLLHQKRISSF
LVCNAQHPQPLRDLGKVTQLYVSIDAPSKSELKKIDRPLYRDFWERMLECLEILKTSQSH
QRTVFRMTLVKGFNMNEISAYADLVERGLPSFIEVKGATFCGSSDGNGNPLTMQNIPFYE
ECVNFVKALSAELQKRGLGYDVAAEHAHSNCILIADTKFKIDGEWWTHIDFEKFFELLES
GKPFNHLEYIAKTPEWALFGNGGFAPGNTRFYKKKKAAETNIDALQEDVKVTHPIVA
>A0A086QGR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii VAND|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQNVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLRLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGGDSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ARGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGSRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
NQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKALSGKVGRKAGAAECRAGNHELPGAETIDERH
RMHAIGDERATGEGSDIDTKGGDRELQSTVFSEDSHSSSDSGEESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGREARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKERGKAKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A7S3YY13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lotharella globosa|TrEMBL
SSKSLPLHSPKQVAAHASESDLWISIHGHVYDVTPYLSKHPGGKRILLKWAGKDATKAFD
DVQHSDHAKELLEKFVIAKLGEEKNDGAEKETTEPKNAEKEGKKTQPTRLDKNQLIVIYG
SQKGRGERFAKLLAEKTGGKAVSMSSFDPEDLPTLSYCVLICSTYTDGVPPDSAKFFSEW
LGEAMHDWRVDKKILSNTKITVFGLGNSVYGENFNKAAKLLESYVVGLGGTLFYESGVGD
ANIGRDDEGTPESDFDTWSTGMVSFLGELKSAEKDPEKFTALLEKAKSKSEKKDKEKTAT
SEEGLLDMEDLGKVMKARKDDSKGPREMLTPALRKNLSKQGYKLIGSHSGVKLCRWTKAM
LRGRGGCYKHTFYGIKSYQCMETTPSLACANKCVFCWRHHTNPVGREWKWKMDDAKMLVE
GAIENHQKMIKTMKGVPGVKPERFKEAFTVRHCALSLVGEPIMYPQINTFLDLLHSKNIS
SFLVTNAQFPERIKSLHPCTQLYVSIDAATKDSLKAVDRPLFKDFWERFQACLSGMKAKK
MTRTVYRLTLVKQWNMNDVSAYCKLLSLGLPLLIEIKAVTFCGDSKASKLTIKNTPYHEE
VSKFGSEICSRFADMYPTSDRRYELACEHEHSNCILIADTRLKIGGKWHTWIDYPKFHAL
YRLWKEEKKEFTALDYMAPTPEWAVYGAKEQGFDPEEERVRKKGKKAAAARAAAAAKQKQ
ENSTPPGSDGASATISSS
>A0A7K4FGH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MGDQDLSSELQGQGYQLVGRHSAVKLCYWTRESLVHKRDCYKGRFYGIQSHRCLQMSPAI
DSCNLHCRFCWRNQGWENDETMSEYDDPETLIDRSIEAQRRILSGFKGDDTIDLDRWKES
QAPRHVAISLTGEPTLYPKMNRFLELCHSRGITTFLVTNGTNPDALRHLDPLPTQLYVSV
TAPNAEVFRRLTLPAQEDAWDRLQESLVIIRDLNTRRVVRHTLVKGWNLGWVDAYAEMDL
TARPDFIEPKGYVYMGKSRQRLGKSHVPTHEEIGHFARQLARRTGYLVLDESPDSKVYLL
GERAEGRYLPGLGPSGELPMVA
>A0A7U3D2F7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MENKYASVYKKQHYGLVGKHSAVKVCHWTKKELSGEEGCYKGTFYGIRSHQCIQMTPALN
SCTENCTFCWRFQGFDSMHISDEDDPELILEESIKAHRKLISGFKGNSKVTKERWEEAEN
PKHIAISLTGEPTLYSRLGEFIALAKKRGMTTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKQIFNDVLNPALGNAWENFNRTLELLPSLNTRKVIRHTLVKDVNMPYIDEYAALDSKA
DPDFIECKGYVHVGQSITKLTIDNMPSHDSILEFSNALAGKTGYQFTADRRDSRVALISK
DPSMAKINFDEIFKSESKKMIAVA
>A0A7J2S711|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MSLLEETKKILQNQGYGIVGKHSAVKLCHWLRKSLLEGKQCYKNTFYGIESHRCLQMSPS
AFHCTQKCVYCWRFQGFTLTKIDEKDADEPRYILEKSIEEQYRLLSGYKGDDRVSIEKWK
EAIKPKHVACSLTGEPTLYPFLSDFFEECHKKGMTTFLVTNGTNPSAIEKMDTLPKQLYV
TVSAPNEEIYKKLCCPLVPRAWEKLNKILEILPSLNTRTVIRHTLVREWNLGHEKEYAKL
DEKAEPWFIEPKGYMFLGYSRERMKIENMPSHEEIRKFGENLADLTGYEIELERKDSRVI
LLGKGKERRIK
>A0A8H5UGI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella circinata|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YDEPAEPKVVVEEKTPTIEPVEEKKNVRSQGPRRIKGGIARKPSKNKEEEKDTTRPVAPL
VFFSSITTKTAKIAEAYIADFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EVDGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVREVIEHVARTGS
LGEGVPGSGAADESDVEDIAEDEDDGEVVFDDEEPKKKSKSSRDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A2R6FF04|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_1_69_70|TrEMBL
MPKQVSDPDYHSENHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELDGVEWDDPEAVVDASIELQRKLLSGFGGNDDVPRDVFEEALEPRHV
AISLDGEPTLYPYLPELIEAFHDRAITTFLVSNGTRPEVLAECDPTQLYVSVDAPDRKTF
GEVVKAVEDDAWDRLIETLDVLAAKEETRTVLRTTLLAGYNMTHPEWYAAMYDRADADFV
ELKAYMHVGNSRDRLDREVMPDHADVVAFTEAVGEYLPTHPVLRDVETSRVALLAREEDT
WVPELKGGSEFWDRAPYASS
>A0A1V5QPI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon ADurb.Bin336|TrEMBL
MKKLSKVDLIKDFSHKKYGFFKDASIQVCEWNKKALRGEGVCYKQDFYGAHTLSCHQITP
VTFWCNNSCVFCWRPNEYMGPTPDSSAQNTNPNELIEGLISARKKLLTGFKGHSSVSKNI
FDSSQECRHWAISLSGEPTLYKNLPKLIKELKKRKGVETIFLVSNGQNPSMLKRLKKEGA
LPTQLYISMVGPNEMVYKSITCNFQKRGWVNYLESLALLPLLGTRTVIRLTLIKGVNDKS
ELVSEFASVLSATGSDFIEIKSYMWLGFSRDRLGKNNMPTFKEVKQFVSKLLELLPDYKF
ENEKENSRIVLLKRKDSKYKTKIIDRD
>Q97ZG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)|TrEMBL
MCDRMYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFY
GIESHRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHRK
AVSGYLGRNDVSIQKVKDAMKPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGV
RPDILASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRF
TMIKGYNMSEQDAKEFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKI
LGQYTGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWNWSTIDMEDDMSGEYKEAEQGC
TEGST
>A0A8H3V9A2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Venturia inaequalis|TrEMBL
MTLPLNLWELPQELLELWHDYRNPIILSVVAILTAVRIYLRFRAGREKLSESPIPGSPQS
LFDEKTEKLPTVVPGLEDDHVQDFTFVEPKRILRKTSPKRVTGKKLRPVASDAATFDHET
DSLQPLVFFSSLAGGTEKTAQEFVKNVSQWKDDADFAGIDRVLPAITHDLSYIEYDDYFI
NPPKDSKAKCFYIILLPTYNIDTVLDLFLEHLKETHNDFRIDTAPLSGLLGYSVFGFGDK
EGWPTEEEGFCSQAKEVDKWMAKLTGRKRAFPLGMGDVKGDSKERLEEWRLGVQEVLGDL
MSGKGLGEGVQGSGDAVESEDEDIEPELKSNLDDVEDLGRSYRNGQTTKAPLAVDFTTIN
KAKAPVSTVKEMVPKDSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYG
IASHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDLPEMIFEGVKAGHYKKIKMMK
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNAQHPEQLA
ALKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFIRCLDILKERRFEQRTVFRLTLVKG
FNIEDEAEGYADLVERALPCFIEVKGVTYCGTSTSSSAGLTMQNVPFYEEIQTFVIALNA
ALEKRGLAYGLAAEHAHSCCVLLASERFKIKGKWHTLIGYEKFFNCLESGKPFKPEDYVG
EPTPEWALWGNGGFDPRDERVDRKGRPKELNLGPRSVGRVVEI
>A0A2Z6RSU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus clarus|TrEMBL
MLLRYFEDLCLNDQILFWSCLAVAGILVFYVTIRNQTQRTKKAKQITVDEYASRKNRELS
AVNKEKATVKGPKRFKSRSAKRTPNQTCTNDLGEKSVCCGNGGNDCCKNQLSEETPYTIT
ANNSSKISIKLFYATQTSTAKYFAQQLYESFTNHSLNCECSIMDIVEYETEDFLSESAIC
IFIISTYNVEGPLDWFYKWLEDTRYDFRVDKQALSKLKFAIFGLGDSAYGDQFCIQPRNI
DKWLGQLGAKRLYPLGEGDKNSDQEKSFEAWKTSLAEMLFDPLSVLNKVSSNLDYDSYSE
SDDERESDSDNNDNSDIEMVDVEDMGALAPKLQAARKSKEEEEFVYKNRSGQPKRTLTEQ
EVPVKEPKEMVTPMLRKSLTKQGYKIVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSH
RCLETTPSLACSNKCVFCWRHHTNPVGKEFVWKVDPPEMILSECLNNHYKMINQMKGIPG
IRADRFQEAFNVRHCALSLVGEPILYPHINEFIKLLHDKHISSFLVCNAQHPDRLRALDK
VTQLYVSVDASTKESLKKIDRPLFKDFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEI
ANYVELVRRGKPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFVKYLNENLGDTYEIA
TEHAHSCSILIANTKFKINNQWFTWIDYDKFFELIEKGEHFTSLDYIAPTPGWALFGSPE
AGFNPEDQRFYRKSKKNNNSVKNGGC
>A0A7C4DAZ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVLKKQKYQLVGRHSAVKRCHWFYKALTGRGHCYKQEWYNIRSHRCLQMTPCAVFCTNRC
LPCWRLEPGDLGFEWDQMAILREDVDEPEEIVEECIRAQRRILTGFNPAHHQLVSEEKWR
EALEPKHAAISLAGEPTLYSELGGLIEAFHRRGMTTFLVTNGVVPERLEEIEEPTQLYLT
LYAPSEDVYKQVCRPLLKDAWSRVVESLSLLRSFSCPTVVRLTLVKGLNFMEPEKYAELI
KLAEPTYVECKSYVSVGMSLRRGLNNSNMVGVGELRLFAEKIGEELGYNIIGESVSSRVI
LLSKLSKPIKVA
>A0A7J3J0Y5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MNSIPLTLIEALKKHRYHIVGFHSAVKRCRWLYESIVNNRPCYKQKFYGIKSHLCVQMTP
ALFYCTQKCLFCWRAQSGDLQLTWEEFSFPKWDNPEDIVEGCIKAQLEILSGYKGNPKAN
QEKLKEAYRPRHAAISLTGEPTLYEPLGDLIHEFHKRSFTTFLVSNGTLPSALENLSEEP
TQLYISLCAPNENIYETVCRPIIPDAWKQLNKSLELLCSFSCPTVIRITLVRGLNMINIE
EYAKLIDKANPTYVEPKAYMHVGFSRLRLKYEHMPTHAEVKDFAIKLAKETGYNIIDESE
ESRVVLLSRLKKPKKLSLN
>A0A820J652|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria socialis|TrEMBL
MAVDINILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSSKS
QPSTKNNSDEKNGITIIFGSLKGNSRTFAKLTSEKLSNEFTREVILQDLNDITDPEEFLQ
IQAKQQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAIFGCGNSL
YNENFNKVATEIDRCLSELGAKKLLATELADENTGKSIYGGLEGHYSKWSSKLISALESK
ATGKCDCTANEDSATTCCKSTSTNGHSKETNGTNEVLIESDDDDEGGCKDGEEDVMDLED
MGDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCY
KHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIGNHYK
MINTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQ
FPDEIRVLQPVTQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKAKGQRTVYRLT
LVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVVTFVRLLC
ERLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGAETFTSLD
YMAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>G8Y946|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695)|TrEMBL
MLDLALYSLAGAIYLISGGRWTIALAGTVLYYLHQSNTSKKVVTNDKPIKVEKSKKESPI
YAVDFTSSSVTPAVTTRIPRNKVTVSRGKGRRSPKVIKATRPISEQDDATLTRSAVSLLH
SQIYIFYTTLTGSSQRVARKLHEKLTNLEDLKNKPKLLSLDDDVDDLEEYFMKTPGGAES
KNIYLMVLPSYETDSPIDYFLEHLKETYNDFRVDKYPLRSLLGFAVLGLGDSESWKGEQF
CYQARLADRWLGKLGARRLYPVGQVCMKYEGEPKAQDWINGFSALLCDDEPFYIDTNELD
DSDAEDGSEDVDGETLVDVEDMGDIIRKSGAKTAGEEQNVKQMVAKDSPTFKSLTKQGYT
IVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNP
VAKSNWRWELDPPEKVFEGALQGHYQKIKQMRGVPGIQMDRFEEAFKVRHCALSLVGEPI
FYPHINEFVELLHEQHISSFLVCNAQHPDQLANLRKVTQLYVSIDAPTKGDLKKVDRPLN
GDFWERLMSCLNILKTKQSHQRTVFRLTLVKGFNMNDVSGYADMVIAAQPSQIEVKGATF
CGSSNANGNPLTMQNIPFYEECKQFVQNLTNELKARGYKYDIAAEHAHSCCILIAHEKFM
INGKWHTHIDYEKFFQLLESGTEFTDIDYVKETPSWACWGSEEAGFNPLDTKFDRKAEKL
KKKAEREEKANRVLELQTAQ
>J3S1E3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crotalus adamanteus|TrEMBL
MDTPADTWDNFHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKVKEQNKNRLAELNLPK
ITAAEKEQDPSLDKVHVAGVKVFYGSQTGTAKRFALVLTEAVATINLPAEIIDMQDYDPD
DSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFGL
GNSVYADHFNTVSRNIDKWLWMLGAQRILSCARGDSNVVKSQHGSIEADFEAWKAKLLTR
VQALAKGDQKACSGTCKKGRCRSKPKVREEAKEPETSKHAEKEEEDLFETTSEEESDIEN
GRGADQVVDVEDLGKMMGHMKKSQKEHQTDGEVPIGVGTQHGKGEDGRREMITPALREAL
TKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNLIKQFKGVPGVRNDRFREGMEAKHCALSL
VGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQRFLDSLQALAEKQQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIKG
VTYCGESSASSLTMANVPWHEEVKRFVQDLADLLPDYEIASEHEHSNCLLIAHKKFKIEG
KWHTWIDYDRFQELVHEYEQSGGIKTFTSSNYVALTPPWAVFGAKERGFDPMDTRFQRKN
KIKDISGC
>A0A397GSE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus turcosus|TrEMBL
MLTDSLFIGLLAFWHSYRLLFLVALSTVFVGLRFYRKLQPRTKTTASSSVPPSPRSQSPE
KTEKGVSLESSNTRTTQKAERQLPVANGPKGTSGPKRVTGKKPSKVAGRQGQKEDAEPLS
FIQPIIFFASLTGNTERYAKILLEELRAAAQKRTDLQDRERGLLPPQIHDLSYIDLDDYF
TSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGSLSSLAGYSVF
GFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAESSLKEWSRGLQD
ILFDILENGGLGEGVPGSGDPVESDEELDDEDVDKSNAQNVVDLEDIKFGGDQNAAGSPI
PVDFTTTGKSSSGQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGS
CYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFQGVKEGH
YKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGEHISSFLVCN
AQHPDQLESLRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRTV
FRLTLVKGFNIDDEVVGYANLVEKALPCFVEIKGVTYCGTSTSAGASLTMQNVPFYEEVA
QFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKEKA
DGTTFTPEDYMRETEDWALWGNGGFDPNDERVYNKGKKKNMQITAEP
>A0A497HF93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDEQLKRIFEKQGYTIVGNHSAVKYCHWVRKSLIFNIPCYKQTFYGIESHRCLQMTPAVN
QCTQKCLFCWRYQGFTETKIDEKEADSPEFIFEKMLEAHRQQVSGFKGDERCDEKRWEEA
RNPKHVACSLTGEPTLYPFLSDFFEICHRHGMTTFLVTNGTMPEVIEDMDTLPTQLYVSV
CAPNEEIYKKLCCPMIKNGWERVNRTLEILPSLNTRTVIRHTLVDKWNLGYEKEYAKIDS
KAEPWFIEPKGYVHVGYSRERLTMENMPSHEKIRNFGEKLASMTGYGLVAEREDSRVVLL
GRGKERKI
>A0A7C7HT53|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHLVGEHGGVKICHWTKESLLRDRSCYKGKFYGIASHECLQMSPVVD
QCNLACTYCWREPHMDSLELTDQDPLELLYESVRAQRRLLTGYGGNIAASPEKFIEAQNP
KHVAISLNGEPTLYQNLSEYIDLCHQHGMTTMLVTNGTLPKAIENLDVLPTQLYVSVDAP
NEEVFNRICKPKWGSAAWQKFEQTIDLLPSLDTRIVCRHTLVKGENMNPEHLAQYAALDN
RADPDWIECKGYVFVGHSREVMSLENMPSHDDVLEFANTLAPLVDRRLLDDSRPSRVALV
GREKIPLPIPEKIMDFPEDLGIAPPIKHLTLAKATEN
>A0A218X810|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Punica granatum|TrEMBL
MYPSSLSARFTFLALLSASTLYFLYKSRRLKTLNLLLSQKPKPSRGKLLYVSQTGTSKTL
ASRLGSLLASCGLHLDLLDVRNYEPEDLSKETLVLVIASTWEEGKPPENAVFFTNWLAES
AADFRVGSLLLSQCQFAVFGVGSSAYGATFNAVAKDFSRKFKALGARELIPVTLGDIDRG
ELDGVFEIWSKRVVEKLKGSGNLSENGGFLNGGVIDSDAESSADGFDSDEEDGENNGGAE
QVVDLEDIAGKWSSRKSGSVVAESNGQVNGKRDMVTPVIRASLEKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWRMDD
PLEIVDTAIELHTKMIKQMKGVPGVTQERLSEGLSPRHCALSLVGEPIMYPEINALVDEL
HRRSISTFLVTNAQFPEKIKLLNPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLQ
SLKEKQQRTVYRLTLVKGWNTEDIDAYYSLFSIGKPDFVEIKGVTYCGSSATSKLTMENV
PWHADVKAFSEALALKSEGEYEVACEHIHSCCVLLAKADKFKVNGQWHTWIDYEKFHDLV
ASGETFDSKDYMAVTPAWAVYGAEEGGFDPDQSRYRKERHHRSNR
>A0A1U8A8J3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nelumbo nucifera|TrEMBL
MRAEMMGKSSSSLSARFALLALVSASTFYCIWKYRRLRSQRLSSRSRNPNLDISCRRGKL
FFVSQTGTSKTLAHRLFDILNSNSIPFDLVDPKDYEPEDLSKETLVLIVASTWEDGKPPP
NSNFLANWLAESVDDFRVGSLLFSDCKFAVFGVGSQSYGETFNAVAKDFSKRMRALGASE
VLPVCEGDVDAGDLDAVFGAWSWKLVRVLKGGLLENGKPPGTALFTESEVESVDDSEDDY
IEENGPESVIVDLEDIAGKAPPRKSSTSAVTNGEVNGKKEMVTPVIRMSLEKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WQWKMDDPLEIINGAIDQHTKMIKQMKGVPGVTLERLSEGLLPKHCALSLVGEPIMYPEI
NILVDELHRRRISTFLVTNAQFPERIRMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWE
RFIDSLKALQEKEQRTVFRLTLVKGWNIEDIDAYSKLINIGKPDFIEIKGVTYCGSSATS
KLTMENVPWHTDVKAFSEALASKSNGEYEVACEHVHSCCVLLAKVEKFKINGQWFTWIDY
EKFHDLVASEKPFSSNDYVAATPSWALYGAEDGGFDPDQSRHRKERHHRPSH
>A0A7C3YNG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geoglobus ahangari|TrEMBL
MMKTLADLKGYQIVGKHSAVKTCLWLKKSLKDQGFCYKQKFYGISSHRCLQMTPALICNL
SCIHCWRPLDLMPPFKEWDDPSFIVEESIKAQRRLLSGFHGTEGVNKKKLMEAYQPNQVA
ISLIGEPTLYPCIDELIDEFNKKGFTTFLVTNGTNPKALEVSEPYQLYISITAWDSESHK
TLQKGNLWERIEQSLKIMSEKDCRTVIRLTLMRGVNMNPEKFVRIIEKASPDFIEAKAYM
YLGYSRKRLSRDAMPEHSEVVEFSQELAKLTSYEIRDESEISRVVLLER
>A0A0R0GAM1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glycine max|TrEMBL
MSISISLSSVPARLTLLAVFSATTFYCLYKYHRLRHLKLFLNPNPNPNPKIIFVSETGTS
KTLARRLHGLLASNDVAFDLVDAQHYEPEDLPKETLIILVASTWLDGAPSAASRFFATWL
ADAAADFRAGSLLLSRCRFAVFGVGSRAYGDSFNAVARGLAKHLRALGAAEVVPLFEGDV
DGGDVDAVFDRWCEKVVAVLKSGSVVESCDNDGAEESGVVSSSEDESDVDSSEIVDLEDI
AGKAPSWRKAVANGEESNEKLNGRREMVTPVIRANLEKQGYKIIGSHSGVKLCRWTKAQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIEIVNS
AIDLHTNMIKQMKGVPGVTLERLSEGLSPRHCALSLVGEPIMYPGINALVDELHKRRIST
FLVTNAQFPEKIKSLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKEKHQ
RTVYRLTLVKGWNTADIDAYSKLFSLGEPDFVEIKGVTYCGS
>A0A2A2HCX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera cuniculi|TrEMBL
MLISQQKQKDLEKKGYRFAGKNVHAGNKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PSIPYCQHKCLFCWRDTEITKVSWDTDDYDDPKTIIEDCIENQKKLLCGFFGNEKANPQK
LKECVKPNNAALSLAGEPLLYPEINQLIDEFHKQDFTTFLVTNGESPEDLKKLEENEPTQ
LYVSLDAPNNEIYQKVCKPQIENGWEKLNETIQLLSTYDTRKVLRITSVKDLNMTNPEEY
AKIIDKADVDYVEIKAYMYVGDSRERLKWENMPKTVDIQNFATEVAKNCGMEIIDEVEKS
RVLLLGDKKPKKYNN
>A0A7C4E4P4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MEKIRISGRVLEKLKKAHYGVFGHSAVEICLWNKKAIRGEGVCYKRKFFGIETHRCMQFS
PAAAYCENRCIYCWRFSEFYRILNMPEEAVDDPQEIIENLMRERRRLLSGFFGNVKANKE
LLKEAMIPSHFAISLIGEPTLYPKLPKMIKYLKSLPHTRSVFLVTNGQEPQMLKRLEAER
ALPTQLYLSLNAGSMEKFREINRPLLPDAWERFWESLEFLRKNEVRSVIRVTLIKSLNTN
EEELEKMCELIKVANPNFVEVKSYMHLGYSTRRLSKTNMLTQLELKKCINKMLKHLRFFK
YMDEQEESRVIILQNVERFVERWILRPEESTLHKFNL
>A0A832WAP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEIVDNDDDNLIQIRPSIVAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKF
YGISTHQCMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPEKVAEPEQIMTKLMAERKKLI
DGFYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKTLEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLDMLKHLDTRTV
LRITLIRNYNDQKEMIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMSEVKKF
SEQIAKESKIFSIMDESLVSRISVLQNNERFIDRYIPTYSNTN
>A0A6A6VXV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudovirgaria hyperparasitica|TrEMBL
MSSILTDTPDGLFHTILKALKALPRELLVSWHLYRIPVLAIVSVFCGLIILFTSRYRWYD
EPRGASNLKERPEQSIASVIQNKISLEQKIVAQKIGPRKIVGQKPQSRAKLSLDTFDHTT
QKVQPLVFFSSLSGTTEVAAKKLTEELDSWIKHSESDYTPLEPRVLDISYVELDDYFITA
PKDDPAVKYFYLILIPSYDIDTILSNFTEHLRETHHDFRIDTAPLSGLLGYAVFGFGDKE
DWPSEEEGFCYQAKEVDKWLAKLTGRKRAYPLGLGDIKSDAIARLEEWRMGVQDALGEIC
AGNGLGEGVPGSGDPVESEDEDEIYEDDEALAETEVAVQPKARKTKPSTRLDDLEDLGKL
VQKTEETDTGPIAIDFTTYKPSKPRKSALTATIKEMVPKTSPTYASLTKQGYSIIGSHSG
VKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRW
VTDPPDMIFDGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEL
LAILHSHRISTFLVCNAQHPEQLAALVPVTQLYVSIDASNRESLRRIDRPLHRDFWERFL
ACLDILRARRHEQRTVFRLTLVKGFNVDEEVAGYADLVERALPGFVEIKGVTYCGTSASS
SAGLTMQNVPFYSEVTDFVTALSAELERRGLGYGIAAEHAHSCCVLLASERFRRAGQWCT
TIDYKRFFELVESKGKFGPEDYIGQPTPEWALWGNGGFDPRDQRVVGRKGKRKHVIEPTP
EAEVAAEG
>A0A2R6EJF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_1_67_19|TrEMBL
MSESDGPKQVDSPEYHHENHTAAQTCGWTANALRGEGKCYKNIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPEAVVDASIELQRKLLSGFGGNDEVPREVFEQSM
EPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPDVLRECDPTQLYVSVDAP
ERHTFDEVVKAVEDDAWEKLVETMDVLADKDETRTVLRTTLVGGENVHHPDWYAGFYQRA
DPDFVELKSYMHVGESRDRVARSSMLDHEEVVEFAEQVQEYMPDHRYLKEVPVSRVALLS
KTDDTWGPKLSFRRVRLLSRSSGIWKQLF
>A0A177DKP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria alternata|TrEMBL
MALLELLEQLPAELLFIWHQHRLPILLAALVVATVVRLAIYSRDRREKLSLSPAPSSPVP
VEEKPTVQLKPEWLPEYTTLNSSELNVDNHAEDDTRAVAAAAKVKKGPKMVKGRKTPKKL
IAPPTFNHQTDRIQPLVFFQSLSGTTERYAKQFAGVLTEWTRGCDQSKSFLEPQTLDISY
IEHDDYFISSPKGDANVKYFYIILVPTYNIDTVLDVFVESLQETHNDFRIDTAPLSGLVG
YTVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMADVKSEAEERLQDWRV
GVQDALVEIAEGRGLGEGVPGSGDPIESDEEDMAEENGQSTRVDDVEDLGSMVNSSAEPI
PVDFTTYKKSPAKSQSLQAPKEMVPTTSPTYAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDMIFDGIT
TAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLGIMHSNRISTFL
VCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMENVPFYE
EVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRNDRWATRIDFERFFDLYE
GKVEGTRVEDGKVVGWRPEDYVGEETPEWALWGNGGFDPRDARVYRKGKGPKVSEEGGKA
TAAALEF
>A0A7C0VNT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MRLKIDDLLKKHGYHRAGRHSVVKTCLWLNRSLRGEESCYKSRFYGIQSHRCIQMTPTLS
CNHRCLHCWRPIEVPVPLPTSSDWDSPVEIKGSIIAEQMRLISGYGGSETTDMAALEEAR
KPNQVAISLAGEPTLYPHLPELIDEFKADGMTTFVVSNGTQPDMIAKIAPTQLYISLNAP
DEETYLRVCNPCGNFWEDIKRSLKVMGARRSGKGAMVVTGEGATTRTRTRTAIRITLIKG
FNIFDPAGYARLLLMAEPDYIEVKAYMHVGFSRKRLGRDAMPEHEEVLSFASEICDETGY
RIVDDVGVSRVVLLSR
>A0A7K4HN81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofollis tationis|TrEMBL
MPSEPCEEGRIALRKQGYQFVAPDATAAVKPCLWNKRTLRGGDMCYKHQFYGIESHRCVQ
MTPTLRCNQRCLFCWRSFEHETTEERFCTPEEIADALPVLQKKALSGYKVSQYVTSERFA
EALDPNMVAISLSGEPTLYPYLPEYIDLLNERGYTTFLVSNGTMPDMIRRCRPYQTYISL
DAPDRETYLALCNPQEDYWDRIHESLSILAARRSAVRTTLVKGKNDFDPAGYAAMYEASG
ATFIEVKGYMYLGNSRKRLSRSAMPEHEEVRRFAEAIAGHCSYRITDESPISRVVLMERE
V
>A0A533VBY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEYISHTGTQNLIQISPLTKAKLKKAKYGVYNHSAVELCHWTKKSFSNEGTCYKHK
FYGISTHRCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPENLVDEPDMIINNLLEERKKL
IVGHYGNTKTDKKKLDESLFPEHYAISLSGEPTMYPKLPNLIRYLKTLKNTKSIFLVTNG
QEPEMLQRLTDEDSLPTQLYLSTNASNKKMFTLVNRPRYKDAWDRWNKSLELLSKMDTRT
VLRMTMIRNFNNSTNYIHEFADLMRRGDPNFIEIKSYMHIGMSTQRLENSDMLEMDEIRS
YSHFLSKSLGTFTIMDESEISRIVVLQNLKRYTERWIEAYEKPIIQ
>A0A533WT51|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEHVSHSTDNLIQITPQLKARLEKAKYGVYNHSAVELCHWTRKSFANEGNCYKHKF
YGISTHQCMEMTPAAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDVIVEQLMAERKKLI
NGYYGNTKNDKRKLDESLLPAHYAISLSGEPTMYPKLPKLIKYLKSLKATKSIFLVTNGQ
EPDMLRRLTAEDALPTQIYLSTNASNKKMFHQINRPLHKDAWERWWESLRFLATVNTRTV
LRMTLIRGYNDSKNFVGEFGEMMAKGNPHFIELKSYMHIGMSNRRLEQDHMLEMKEVRDF
AIQLCEKMSSFKMMDESEVSRIVVLQNQARYTDRWIKEYIMPAS
>A0A7S0E466|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hanusia phi|TrEMBL
VDLFSLAAGNFAEKARQALASAPVFVFITSTWTDGTPPPSCSGFFSWLRDDDCRRELDFN
NLRFTVFGLGNSEYAANFCKAARDLDERLAALGGTRVCARGEEDDYSPSIFGSWKDSLWV
SQGARLMGNSVQFIKEDSDENSSSSAQEDDDLDDMLQGEEGGTCGSKAELEDLEDLGKIA
TRSKEKEGVVSLRGKPKKMLNSALEASLTKQGYKLVGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIASYQCMEATPSLACANKCVFCWRHHKNPVGTSWRWETDDPQFLVDGFISKHRAM
IKEMRGLPGVLPDRLEEADTVRHCALSLVGEPIIYPHINKFINLLHEQSISTFLVSNAQF
PAQMENLVPCTQLYVSIDASNAEELKAVDRPLFSDFWERFLECIDILERKGQRTVFRLTL
VKSFNMSEVEGYAKLIRRGQPDFVEIKGVTFTGGKKPQLGMSNVPWHAEVVSFASEICKL
VEDEYEIASEHAHSCAILLAHKKFKRGSDWYTWIDYPKFFDLVRSGQPFTSLDYMTKTPE
WAVYGRGIPGDGGFDPAEIHYRKGDSRMSTPMSSRPETPSSFR
>A0A6A5ZQ35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lophiotrema nucula|TrEMBL
MAFIDSLGALPEQLLSIWHTYRLPLVLLTLAIALHICLRRIRSRSPPLKTLPEVKCVNHD
HPGHAKEGYTMYGSVAEEFSMCFDCLYAAQIEKLGGGDVMVEMKPEWLPENTTVTNLESV
AVVKEERAVEKVKKAPRRVKGTKVSRRARKPVDVGFDHARDKIQPLVFFQSLSGTTERYA
MEFLAIFNDWSQGSECTKSLLDPQLHDLSYIEYDDYFISPPKASPNTKYFYVILVPTYNI
DTVLSTFLENLSETHNDFRIDTAPLSGLLGYSVFGFGDKEGWPTEEEGFCSQAKEVDRWM
ARLTGRKRAFPLGVGDVKSNAQQRLDEWRFGVQEALEEIARGRGLGEGVPGSGDPAESDE
EEEVDESEDSSSGDQSSKRTERKKKAGRVDDLEDLGGMVNSTNTSTDFVIPIDFTTYSSK
PKPKPAPAPKEMVPVSSPTHTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYG
IASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDSPETIFNGITQGHYKKIKMLK
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLTLLHKERISTFLVCNAQHPAQLQ
SLIPVTQLYVSIDASNKASLKAIDRPLHRDFWERFTTCLDILRNRRSEQRTVFRLTLVKG
FNMADEVRGYADLVERALPGFVEVKGVTYCGTSDSKSAGLTMQNVPFYEEVAEFVRALSD
ELVSRGLPYGIAAEHAHSCCVMLADETRFKRDGKWATRIDFEKFHDLTEGKVEGTRMVDG
KVVGWRPEDYIGNDTPEWALWGNGGFDPRDQRVYRKGKGPKAEEEKPEVRLVEI
>A0A812A054|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Argoarchaeum ethanivorans|TrEMBL
MLISSNFESLLKKHGYHMAGSHSAVKTCLWLNKSLRGEGKCYKFQFYGIASHRCVQMTPT
MQCNQKCLHCWRPTEIDVPETGWDSPELIVEESLKAQQRLISGYGGADIIDKTLWEEAKN
PRHVAISLAGEPTIYPYLDHLIDAFHSKNMTTFVVTNGTYPAMVERINPTQLYLSLNAPD
EDTYRQTCNPQEEGLWERICKSLDILREKQTRTVLRITLTEGLNITNPEGYATLIDRAGP
DYIEIKAYMHLGFSQKRLERSAMPTHQRIREFSERIMQYTDYKQADESQISRIVLLSKNG
DVKKIV
>A0A1L7XIT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phialocephala subalpina|TrEMBL
MAHGKWNLRPLLPVEVIDIVTLWHTYRVPIIITTFTILIIFRTILHLRVPRVKVSDTPPL
SPKLPAEKEKAPLEEKFVAEKVPRRIVGGLKKRKSSEDEVVLACQNIQVIVFFSSLTTTT
EKRAKVFADELAQSTKEFAKSTSAIFLEPQLLDLSYIDYDDYFITPPKADANTQYFYLLL
IPTYNIDTVLDSFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQAR
DVDKWLAKLTARKRAFPLGMGDSKVDAAERLREWMEGVEDVLGHIATTGGLGEGVIGSGD
AVESDVEDLDDEEDEVLFEEQKVAQRKTKVQKKDVLNDVEDIGNTLNLTPADPSEPLELD
FTTYNKKARSTPTPVIKEMVPKNSPTYNSLTKQGYSIVGSHSGVKICRWTKSALRGRGSC
YKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPELIFDGVKAGHY
QKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNA
QHPDQLRTLKPVTQLYVSIDASTRESLRKIDRPLHRDFWERFQECLQILREKRFQQRTVF
RLTLVKGFNIEDEAEGYADLIEKSLPCFVEIKGVTYCGTSSSAGAGLTMQNVPFYEEVCA
FVEALNASLSKRGLEYGIAAEHAHSCCILIASNRFKMEGKWHTRIDYEKFFQCLESGKSF
TPEDYMGPETPEWATWGNGGFDPRDERVDRKGRPKILPGEAVGKVKVGKEDEAGE
>A0A7C7ZC86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSETLHKIDDDPYELFLESVRGHRRLITGYGGNPKADPEKFREAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPDFIEAKGYVYVGNSRNNLAIENMPSHDDVMGFSRRLAPLVGREVLSDRSESRVALIGK
EMVPITLPEKVRELPKNLGIAKPQRYMLPQA
>A0A7L0FCG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corythaixoides concolor|TrEMBL
LDVLMDMWNFFHACLVSVWLHRFYLYSVVAFGISVWIVVQFFTTKTKKKVTEGVSTSASE
GIEDKLVNGCATLQAQEVCVAGVKIFYGSQTGTAKRFATSLAEAVISLNLPVEVISMGDY
DPDDCLAEETTSRNICVFLAATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRVMTRAEGDCNVAQSKHGSIEADFEAWKAKF
LSRLQALCRGEKKPCSGKCKTGKCKPPGKQSKESSDHEHGTSEYEKTEAEELFETSSEEE
EADAEEAGGTNSVIDVEDLGTIMNHMKKAKVLLLQQGLFDFLFSGYKLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMEATPSLACASKRVFCWRHHTNPVGTEWRWKMDQPE
LILQEAIESHQNMIKQFKGVSGVKADRLEEAMTAKHCALSLVGEPIMYPEINCFVKLLHQ
HSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSLKAL
SEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEVKGVTYCGESSASSLTMANVPW
HEEVVRFVQELADLVPDYEIACEHEHSNCLLIAHKKFQINGEWWTWINYDRFQELVQEHE
RSGGSKTFTAADYAARTPHWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A3A5V9T6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNDNAWDKFSETLDLLPSLDTRIVCRHTLMKGINMSDEHIKQFAALDM
RADPDYIENKGYVFVGHSRENLGVENMPSHEDIMDFSAQIAPLTGRKILSDSRPSRVALV
GQEISPIPIPEPTMFFPDDLGIAPSVKHLQMAS
>A0A852FI34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Peucedramus taeniatus|TrEMBL
LDVSMDMWSYFHTCLMSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPVSTSLLE
DPKNLGGNKLGNGCVPHQAQGVNVAGVKIFYGSQTGTAKRFAKALAEAVASLNLPAEVVN
MEDYDPEDHLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGL
RYAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAW
KAKFLTRLQALCRGEKKPCSGKCKKGKCKSSGKQSKESLDYEHGTSEQDNTEAEELFETS
SEEEAGGTDSVIDVEDLGNIMGHMKKAKREQELQEGAAGAERREMITPALREALTKQGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPEVILQEALEKHQNMIRQFKGVSGVKAAQLEEALAVKHCALSLVGEPIM
YPHINHLVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFK
DFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGE
SSASSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLMAHSKFQVDGEWRTWI
DYGRFQELVREHERSGGSRTFTAADYTARTPPWALFGARERGFDPLHVRFQRQNKARDTS
G
>M1VX10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Claviceps purpurea (strain 20.1)|TrEMBL
MADVCPRTTTLQGLLSGCSGVKFDDIVELWHKNRTPLIFCALVLLAVIRLYLHKNEEPIP
LKALPDTSPKKVVAEDATKPRDVVAVAKTSIKSDGPRRIKGGIAKKLTTEDKELHDKSRP
VKVLVFFSSVTTKTETIARQYLDTLVKCTDQLSQATGRQFLSPELHDLADIDFEDFFVSP
AKTAENAYLFYLFLLPSYNIDTINDTLLQHLEETHHDFRIDTAPLASLLGYSVFGFGDKE
GWPDEAEGYCFQAKELDKWMSKLTARKRAYPVGMGDMKGDHAERFNEWASGIQEVITHVA
RHGSLGEGVPGSGDAVESDAEDVAGEDDGEVLFEDEISGEDETSSRPLDDVEDLGRMLRT
SESKDNSSTTSNKKAAPLAIDFTSHGSSAVKKTKRTQVAPVVKEMVAKNSPTYAALTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGIHSHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPEMIFEGVKEGHYKKIKMLRGVPGVRADRYAEALRIRHCALSLVGEP
IFYPHINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPL
HRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGV
TYCGTSTSSNAGLSMSNVPFYWEVCDFVKALEKRLKAKGLKYGIAAEHAHSCCILLASER
FLVDGKWHTHIDYTRFFELLEGRGPDGDWMPEDYMGEPTPEWALWGNGGFDPRDDRVDRK
GRKIENVVVREAPPPESW
>A0A3S5H5J8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania donovani|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTAPPAAAEDVICPLVRVMEMREEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGVA
PPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGLG
APPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAASA
TEARSCKGGSATLATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCAC
RKADTIADGVAVSKSDDDDDDSNAENDGMDDVEDLVWDGTDDVDFDLSKDPSELPELLYP
KLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACAN
KCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLAMAMQIR
HCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRNLKPVVQLYLSIDAPTP
EELKRIDRPLFEDYWDRCLSCVKELARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQPD
FIEVKGVTYCGTSSNSTLNMKDNVPRHDEVVGFCKALCAEMASRHPHYRTPQMDKEEEGG
GDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRTDF
TSLDYAAVTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTASC
>A0A6V8DUM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFHKLEETLELLPSLDTRTVCRHTLIKHESLGFHEDYARLDNLA
DPDFIEAKGYVNVGNSRNNLSVENMPTHQEIIEFSEKLAPLVGRKLLSDRRESRVALIGK
KMIPVDLPIASMDLPKDLGIAKPQRFMLPQV
>N1R5X0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. cubense (strain race 4)|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFYINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8C7D0J6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oncorhynchus kisutch|TrEMBL
KWPFIQQGYFTLHPVSYEVHLIWLCANVLNFIKKWGPFLSLTGNIYQSMSMLHIQHLFSL
SSKIWKVAHLSLQCSNKSVCVFLLATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGL
RCAMFGLGNSVYGSHYNMNVDKWLWMLSGICVLSRGDSNCKVVKTHNGSAQADFLVWKTK
FLNCMQALVAGQKKACSGNCKTDGSCKTRNRKKPQEKTEDDQEVLVESSSDEETTGSEVK
DPGSVIDVENLGNMKAKAIQTQTILWICHWTKSILRESGGCYKHSFYGIESHRCMETTSS
IACANKCVFCWRWVTHTHKNMIRQFRVLLGCIQSGMHSTLSLVGEPIMYPKMNAFLYLLH
THRVSGFIVTDAQFPQEIRWGYCSYDEDISKYQPPSPLSPSLPVPLSLQGVTYCGESHPF
VQQLADMLPNYQIACKHEHSNCLHIVHTKVAG
>A0A8C4B183|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Denticeps clupeoides|TrEMBL
MDEADLNGVLETLCGRWGGVAVSLWQNRRFLYAALAALVGLWLGLSWVLRQKLLSGAEAP
QEEAKKSMVGTGEEDAGPRLHVKIFYGSQTGTAKGFAADLCEELKAQGFDSEVLDMKGYD
PDDRLAGESSSRVVCVFLLATYTDGCPTENAAWFCKWLEETSTDFRYSSTHLKGLRYAVF
GLGNSVYEGHYNTVGKNVDKWLWALSASRILPRGEGDCNVVKSRRGSVQADFAAWKTRLL
NRLQEIGHGEKQPCDCRNGSCKNKHAGATPIERHQSGEEPVGCSSSDEDEGVEQPSVMDM
EDLGSMMGRARRNKKQDEASGTAETSEEERREMITPALRDALSKQGYKLIGSHSGVKLCR
WTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQP
DMILQEAVEKHRNLIRQFRGVPGVRADRFDEALHVKHCALSLVGEPIMYPDINRFLRLLH
QRHISSFLVTNAQFPEEIRTLVPVTQLYVSVDASTRDSLRRIDRPLFKDFWRRFLDSLQA
LGDKKQRTVYRLTLVKSWNVDELKAYADLIALGQPDFIEVKGVTYCGDSSASNLTMANVP
WHQEVIHFVQQLSDLLPDYDIASEHEHSNCLLLAHHKFKVDGEWWTWIDYERFHVLAQRY
EDSGGAATFSSLDYVAKTPGWAVFGAQERGFDPSDTRFQRKSKKDISGC
>A0A2G9PUI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG08_land_8_20_14_0_20_43_7|TrEMBL
MAEDEAYRKLLLKQGYGLIGRHSAAKICTWTKKSLRGEGVCYKERFYGIRSHMCCQITPS
MGYCQNRCVICWRDLSKTYGTEMVDDGTLDEPKDIIKGAVREQRRLLNGFKGFEGADLEK
FEASKNPKNFAISLSGEPLSYPKLNKLIRELHAQGNSTFVVSNGMLPDALEKLERPTQLY
LSLDAYDEENLKKIDRSLFSDAWQRLMRSFDIMSSLKDWRTAVRVTLIKGWNMEHPEKYA
ALLERANPRFVEVKAYMFVGSSRTRLELENMPYHHEVKAFAEKICKHCGYKFIDEQEESR
VVLLMKEDRPDRIMKF
>D3S0A1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ferroglobus placidus (strain DSM 10642 / AEDII12DO)|TrEMBL
MAKTLADLKGYHIVGKHSAVKTCLWLKKSLKDEGYCYKQKFYGIPSHRCLQMSPALICNL
SCVHCWRPLDLMPPFKEWDEPEFIVEESIKAQRRLLSGFFGTAGVNRRKLEEALNPKHVA
ISLIGEPTLYPRIDELVDEYKKRNFTTFLVTNGTNPQALERVEPYQLYLSLTAYDEESHK
ALQGNKWDKIEESLRILPNLDFRTVIRLTLIKDVNMKPEKFAEIIDKASPDFVEAKAYMY
LGYSRRRLKAENMPEHEDVRRFAEELAKLTGYEIKDESEVSRVVLLVR
>B9R7T9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ricinus communis|TrEMBL
MSLSSYRARLALLALLSASTFYCFYKSRRLKQLKTSFIPTAVTSSNRGKLFFISQTGTSK
ALAQRLHILFKLNDLSLDLIDAKDYEPEDLCKENLVIIVASTWEDGKPPSNADFFANWLA
ESADDFRVGSLLLSNCKFAVFGVGSRAYGDSFNAAAKDFSKRLRELGANEIVAIGEGDVD
SGEIDAAFEEWSGKVVGVLKGGSLENGFIGCESENDNVVVDDDDFQSSDEENGELESGIV
DLEDIAGKGPSRRRFNAVTETNSKPNGQKEMGYKIIGSHSGVKICRWTKSQLRGRGGCYK
HSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKNWQWKMDDPLEIVNSAIDQHTKM
IKQMKGVPGVTMERLNEGLSPRHCALSLVGEPIMYPEINTLVNELHQRRISTFLVTNAQF
PEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKALREKQQRTVYRLTL
VKGWNTEDVDAYFNLFSIGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALAL
KSKGEYEVACEHVHSCCVLLAKTEKFKVNGQWFTWIDYEKFHNLVASGKPFNSKDYMAPT
PSWAVYGATEGGFDPDQSRYRKERHHKSSH
>A0A897NMA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halapricum desulfuricans|TrEMBL
MHTGTVDGDMSDEGGPRQVGDPDYHSVNHTAVQTCGWTDNALQGEGKCYKYAFYGVESHR
CMQMTPVVKCNERCVFCWRDHAGHAYELGDVEWDDPAAVADATIDLQRKLLSGYGGNDDV
PRERFEQAMEPRHVAISLDGEPTLYPHLPELIEEFHDREITTFLVSNGTKPEMIERCDPT
QLYISVDAPDRKTFEETVKPVEEDLWERLIETLDVLAAKDDTRTVLRTTLVGGENDHRPA
WYAAMADRADVDFFELKAYMHVGHSRGRLDRSSMLDHDDVVSFAREVQSFLPDHDHLVDV
PDSRVAMLARDSDTWVPKLQKGSEFWADDPAAR
>A0A497S9H0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MILSRETISRLEKAGYRFVGPSKHSAIKICSWTREAIRGKNFCYKQKFYGIASHRCLQMT
PALPFCTQRCQFCWRDTTITYPKWVGPIDEPKQILDEAIEAQREILQGFKGNPNVDMKKF
KEAMEPNQVAISLAGEPTMYPKLPEFVDLVNSRGMTSFLVTNGTNPDMIERLLDSQPYQL
YITLAAPDEETYKKTCQPIIPDGWLKLMKSLSMLNQFNRSVIRLTLVKGLNMITPEKYAE
HIEKAGPKFVEAKAYMAVGYSRERLGLPYMPQHSEIRAFAEKIEENSSYRIKDEKADSRV
VLLMK
>A0A7J3W6F3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MEEEKEPIVREGKIRIDEELSIKLRHAQYGIFGHSTVDVCHYTKKALKKEKVCYKRKFFG
IETHRCMEFSPAGLFCHNRCIYCWRPTSFYRTLKLEENKVDEPKEIIENLLKERNKLLTG
FGGNEKVDKELYKEALVPTHFAISLSGEPTLYPKLPELIKYLKSLPQTKSVFLVTNGQEP
EMLERLEREDALPTQLYLSMNAGRIETFKKVNCPLMKDAWERFNRSLEFLAKTKTRTLIR
ITLIKGFNDSKDEIEDFAELIKKGNPHFVEVKSYMHVGYSKSRLTEKEMLSMDEIREWAK
ELQKLLPNFEFMDEDEDARIVILQNRERYVDRWIVRPEESSLFKFGL
>A0A6G1PSP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Channa argus|TrEMBL
MLSFFVFTLLFISRLCASDTKVSKNALGPGESYFMSIWHNRLYLYTAAALVFGIWFSLKV
ALKKRNVPKRGPMVYETVKNNEPTVSDNVVHVSGVKIFYGSQTGTAKGFAKELSEEVMAL
GFPAEVVDMKDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASIDFRY
GKTFLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGS
VQADFLAWKVKFLNRLQVLAKGEKKSCGGNCKSGGSCKNNKKDGRAEEKEKATVQNNSSE
EDLVESSSDESGLEDEKKIGSVVDMEDLGNIVSNVKKTKSKEEDRAASQMVKLSKLNGVM
TLEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIES
HRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVP
GVKPDRYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSHRISSFLVTNAQFPQEIRSLV
PVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEE
MQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIA
CEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELNQAYEDSKGQQGFSALDYIAKTPSWA
LFGAGEQGFDPADTRFQRRNKSKDISGC
>A0A267H9E7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
KMSHWDLTVHISRALQNSSALSYSLLLAASVVGAWILFQRRGRQGHVISASSVKKAVLSS
SSQMSLRSPTTRKAMLPTTSCTSTANGSVDETFNKVRVFYASQLGRAKHFATLLLAELAG
VLKQQKQQQQSQCCNGGDGEACKSTTVSSSDSAGIELIDLANYDPEESLHKESPDTLCYF
LLPTYEGGSPPDTGAWFCKWLAEAAEDWRVERGHLSGLRFIVIGLGNSLYAENYNLIAKR
VDEQLTQLSGTRLRPPVLLDENVASATGHGGQEADFQAALQSQLLDPLVSKKNKSACCSE
ATGNSACCQGAEAASDVAEDHSDVDNDNLDEEDQEGLVDVEDIGGVLSSATRSNQKQKLG
QEATTRRAMVTPLVRKSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIASHR
CMEATPSLACANKCVFCWRHHTNPVGTEWRWLEDPPDEILSGALDAHRRMIREFRGVPGV
MPERISEGMQPRHCALSLVGEPIMYPRINQLLHLLHTSGISSFLVTNAQFPEAMRQLPPV
TQLYVSVDAATPDSLKRIDRPLFKDFWQRFIDCLRAMRDCGQRTVYRLTLVKAWNTEEVQ
QYAKLVDLGCPDFIEVKGVTFCGDSKASQLTMGNVPWHKEVVQFSQALADSLANQYDIAC
EHEHSNCVLLANKRKFLVNNRWHTWIDYDRFEQLYGRFVETGQRFNAADYMAETPEWAVY
GSAEQGFDPNETRFRRRAAAAAAAAAASGDY
>A0A8H5PC71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium pseudocircinatum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPVKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPPKNKEEEKNITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGN
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSTKKVIPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKICRWT
KSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEL
IFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHAE
RISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDILR
EKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKKF
FELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A0L1J6W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus nomiae NRRL 13137|TrEMBL
MAEPFLTEGLVTLWHSYRLPILIAIASVAIILQAYRRFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGERETPAVAEESVPKPAVRNDPVPKVVSGPKRVSGKKPLKVAGRRREDQEPPL
SFIQPIIFFASLTTTTERYAQILLEDLRTAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPPTSPGTRYVYCLLIPTYNIDTILNTFLSHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAESAFKEWSRGLQ
DIFFDILDNGGLGEGVPGSGDPLESDEEDLDDEENDGKGTKRRNGQDVVDLEDIKMGSDG
QTGSGPVPVDFTTVGKSAAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELI
FQGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLLLVCNAQHPDQLETLHRVTQL
YVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRTVFRLTLVKGFNVDDEVV
GYANLVEKALPCFIEIKGVTFCGTSTSAGVGLTMQNVPFYEEIQEFVVSLNKELERRGLD
YGIAAEHAHSCCALLASTRFHVNGKWHSRIDYDRFFELLEKEKADGTPFRPEDYMRETEE
WALWGNGGFDPNDQRVYTKGSKKGLHLAATK
>A0A4Q2VYF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. narcissi|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKMEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A059BRG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eucalyptus grandis|TrEMBL
MYPSSLSARITLLALLSASTFYFLYKSRRRKNLPLVSFNPNGDGSLDALSRRRGKLFFIS
QAGTSRALAGRLFSRLASNGLPFDLVDPQSYEPEDLSKESLVLMVASTWEDGKPPENGGF
LANWLGESAADFRVGSLLLSRCKFAVFGIGSGAYGSHFNAVAKDLSVKMRALGAGEILPL
SLGDVDKGDVDGVFDIWSEKLIAVLKGVEDSGVILENGVGIGGESENESDGGFESDEDGE
SGGETVVVDLEDIAGKGPSRNSGAVAQINGKANGTREMVTSVIRTSLEKQGYKIIGSHSG
VKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQW
KMDDPLQIVDTAIELHTKMIKQMKGVPGVTQERLSEGLSPRHCALSLVGEPIMYPEINAL
VDELHRRHISTFLVTNAQFPEKIKMLKPVTQLYVSVDASTKESLKAIDRPLFGDFWERFI
DSLRELKDKQQRTVYRLTLVKGWNTEDIDAYSNLFSIGKPDFVEIKGVTYCGSSATSKLT
MENVPWHSDVKVFSEALALRSKGEYEVACEHVHSCCVLLAKTDKFKVRGQWFTWIDYEKF
QELVASGNPFDSGDYMAATPSWAVYGADEGGFDPDQLRYRKERHHKTNR
>A0A8H2VH56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kazachstania barnettii|TrEMBL
MDLQSKVYVALGLASPIYLYFGGRLSILVVIWTSVVLFGKEIFGNGGEVPVEPHKCKCSD
KNGDGKTHNHNHEKKEECCGGKGTGVNGKPCCGKGGKAPTAELPKFKKEPIVSKDDQKPK
TKCCGGKGHDVKKHGEVCCGGKGHANEKKVEPVEKKKPKTKCCGGKGHDVEKHGKVCCGG
KGHDDDKKEVAPTPEPIVEKQETKCCGGKGHDVKKNGKVCCGGKGHDKEKNVEIQEELKK
EDNWDSLTVDFTEAFKSPNAKATKKSVKVFSKKGMTEVKATQTDNDADGLIKSAFTVSNI
DLLDSDIYIFYSSLQGSSSKAGSIVQEKLREVSGLQRQPILLNLDEINDLDEYFVNVPSE
KALYVMVVPSYDVDCPLDYFIQTLEENFNDHRLDKFPLRKLVGYTVLGLGDSESWPDKFC
YQATKVDYWISHLGGRRIFPIGKVCMKYNGNDKIVEWANLLGDLLKDNEPILYEYDETVD
NSDDDYDDNDSFDGSNDEEEGSDRDIDLEDVGGKDSNGGTRKINKNSLEVKQMIAKDSPT
YKNLTKQGYKIVGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKC
VFCWRHGTNPVSKNWRWETDEPDFILENALAAHYSMIKQMRGVPGVIAERFINAFKVAHC
ALSLVGEPILYPYISKFIELLHEKKITSFLVCNAQHPESLRTIGRVTQLYVSIDASTKEE
LKKVDRPLYKDFWERMMECLDILRTVQSHQRTVFRLTLVKGFNMGEISSYADLVQRGEPC
FIEVKGATFSGSSKDNVNSLTMQNIPYIEECKAFVERFVGELQRRGMEYEIAAEHAHSNC
VLIAHRKFKIENKWHTHIDFEKFFQLLATGEPFTYMDYLQETPEWALYGNGGFAPGNVRV
YRNEKKTSKNGEADDNRVHPDDLPALPVMQV
>K2PDL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi marinkellei|TrEMBL
MTELVPDVLLWVLLGALIPIFTLTLTALMDRWISRRRKRLMEMARAQVTKEGETTEMEPN
VHNNTGKTNGNGCTVDGAMESSKKGVEVKNILIAYATQSNTACKLAHKLFSTLNTALHES
RDDMQGGSSSCVCSEGPSSCCATSHTVRHLPELKVLQLTEEGRQCGVEHLLESQAYGLVI
LIVSTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLSKMKFAIFGLGDIAYGEKHFNRFA
KNLYMWCKGLGATFVVPPVYASEANTIPLFNVFTASLVKWIGRVTFTVDGVTILKRQQKH
LKGKKEKGQLKTCSDMGIQQHATDNSEEHDEDDEGEEVENEEEKNDGKKRNYNKEGDVED
VVTDDEDEGEEDGIGQSGSETHTMQTSSNEPPELLYPRLRQNLQRQGYHLVGSHSGVKLC
RWTKAMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRTFRWKVDP
PQLLISEGIAGHQKMMKQMRGVPGVTPERLEEGMQVRHCALSLVGEPIMYPEINTFVDLL
HERGISSFMVTNAQFPEQLRVLKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVR
ELRRKPQRTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLTMKEN
VPRHEEVVGFCVALCEALASDIAPRDKRTWLGAESEAGALPRNVNCDETRRSINNMENKH
ERCNGEDEEEKMEGIHFSGPYGIACEHEHSCCVLIALRRFLVNGVWHTWIDYDKFTALAR
SGRTDFTAAEYAAPTPSWAVFRSNERGFDPTQVRVHRKNGKTTVVTSGC
>A0A453LXD0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aegilops tauschii subsp. strangulata|TrEMBL
TGTSKALAARLSARLANAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAPPPGAAFL
ARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGAVEVLPVG
EGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDDDDDEEEE
EEVASAEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQGYKIVGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEI
NTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFSDFWE
RFLVYMQKYLQMHMMKLWFTNINSFYCVLFTSIPH
>S9R0J7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Schizosaccharomyces octosporus (strain yFS286)|TrEMBL
MSFDLAYLEEKWGTYRGLLFYLVLLLPVAAHVLLSRNKKQLAVSSEENLPKEKENTKHKK
TVKRFTRKNVKSKLVQSNSQNEIDLLNSPICIFYATLGGTAQRYANEVHKLMSTNLQRDD
LQLLSLDYIDLEEYFLSCPENAVYLIILPSYAIESSIDFYLSTLRETFYDFRVQKNPLEK
LSGYAVFGLGDMDNYPGDMFCYQAIQTDKWLSKLGASRIAPMGVTNSQLAPATQVDVLTQ
WTNSVLENMKKGTLLRPIDEGEGNSEVMDVEDMGPMMAKAKAESSLPVGTKEMVSTVSPT
YKALTKQGYSVVGSHSGVKICRWTKNAMRGRGFCYKYSFYGIRSHLCMEATPSLACANKC
TFCWRHGTNPVGTEWRWKVDPPELIMKGVLESHYAKLKLMRGVPGVRQDRFLEASRVRHC
ALSLVGEPIFYPYINEFVGMLHEREISSFLVTNAQHPEAFRKMGMVTQLYVSIDASTKQS
LKSVDRPLFKDFWERLLTCLEILREKKQRTVYRMTLVKGFNMEQIKEYTELIRLGVPCFI
EIKGVTYSGNSDQSPLTMKNVPYYEEVVDFTKKLIENIDKYLGDLGVKYEIAAEHAHSCS
LLVAQTKFKKNDMWYTHIDYAKFFELWRTKEAFDPMDYIAPTPDFAYFGQGGFSPEDVRF
VRKQKNKNKPEATPAPTAVPEVAA
>A0A8B8MXK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhodamnia argentea|TrEMBL
MYPSSLSARITLLALFSASTFYFIYKSRRRKDLPLVSFNPNGDSGSDDLSRRRGKLFFVS
QTGSSRALARRLFSLLASSGLPFDLVDPQSYEPEDLSKESLVLIVASTWEDGKPPENGRF
LANWLAESAADFRVGSLLLSRCRFAVFGVGSGAYGAHFNAVAKDLSVKMRALGAGEILPL
SLGDVDKGDVDGLFDIWSEKLIAVLKGGEDSGVVLESGVGTGGESENESDGGFESDEDGE
SSGESVVVDLEDIAGKGPSRKSGAAAQINGKANGTREMVTPVIRTSLEKQGYKIIGSHSG
VKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQW
KMDDPLEIVVTAIELHTKMIKQMKGVPGVTQERLSEGLSPRHCALSLVGEPIMYPEINAL
VDELHRRHISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFI
DSLRELKDKQQRTVYRLTLVKGWNTEDIDAYSNLFSIGKPDFVEIKGVTYCGSSATSKLT
MENVPWHSDVKAFSEALASRSKGAYEVACEHVHSCCVLLAKTDKFKVDGQWFTWIDYEKF
QVLVASGKPFDSRDYMAATPSWAVYGADEGGFDPDQLRYRKERHHKSNR
>A0A850MT29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Helarchaeota archaeon|TrEMBL
MKIMKTILPEEFLGKLKKQKYQVVGRHSGVKACRWTRKALTGGGFCYKQKFYGIQSHRCL
QMTPTIGFCTNHCLHCWRVEPEDINIQWDEQLIENLEDPDPPSEIVEGCLKAQKRILSGY
KPTGHKKVTWEKWKEAMEPTQVAISLSGEPTLYPFISELIDTLNARNMTTFLVSNGTRPK
VIENLSKPTMFYISVYGPDKPTYLRVARPIEPNNWEKLNESLELMNNFNSNTVLRLTLIN
GLNLLHPEGYAKLIEKANPTFVEAKAYMYVGYSRSRLNFEHMPEFSQIQDFAGQLSTLTG
YKILDESAPSRVVLLSKLDKKINISKNSVKQY
>A0A8D3C7H7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MLNFLLVVLLFLTPVSTSDIEVSQDEHSPGESYFLSVWHNRLYLYSAAALVFGIWFSLKM
ALKKKSFSEDVGPLVYKAVTNSDRSDRDTVVHVSGVRIFFGSQTGTAKGFANELSEEVKT
LGIPAEVTDMRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNG
SIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEEDLME
SSSDEDESGLQDEKKSGSVVDMEDLGNIINIAKKAKSKEEGGGGGQVVKLSKMNGVKKIE
DEGEKREMITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVK
PERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVT
QLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQA
YSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEH
EHSNCLLIAHTKCEEKTDLHNSDEPPDLHQRFEDLQITAGLFPAFRSCQQNERNRKTTCY
CKIRAHASFNPSSRWLASGGRGSTTSASRSWFRPTETAADSRASVPWTTWPRLQAGLCSE
PASRDLTLPTCASNDATKPKTSQVADR
>A0A367KKE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus stolonifer|TrEMBL
MSNFINSLLYGFTNILSVGPEPPREGEESGCTGSDGQGCCKDQPKQETSGCCQTKQVEEG
CCGGKGDACACESTNGPVVIDNLKILFSTLTGTAKTLATEMQKKIEENDHVTVEKLEVMD
ITEYDNDQLLQETAVCVFILSTYNVEGPLDWFTNWLHDLRYDFRVDRDALKKLRYTVCGL
GDSAYGEEFNIAAANIDKWLGRLGATRIYPLGECDKNSDQKAQFDVWSNGFVSELQDKHS
LEFSPTNIAFQSDDEEEEEEQEEAQIDIDGGSGDEMVDLEDMGNMASKIKAAKAKRAEED
EEYENSKARPRRQIGSDDTVKKTIQPREMVSPMIHKNLTKQGYKVVGSHSGVKICRWTKS
ALRGRGFCYKHAFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPQFIL
DGAMENHYKMIKQLKGVPGVKAERFQEAFTIRHCALSLVGEPIFYPHINEFVTKLHENNI
SSFLVTNAQFPDKIAEMVPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNCLEQLSLK
GQRTVYRMTLVKGHNTAEIDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVE
VIDFCRQLVAKLDGDYEISAEHAHSCSLLIAHKSFKVNGEWHTHIDYPKFFELVKSGKSF
NSLDYMAKTPEWALHGHEAAGFDPNETRHYRKNRKIVTPPVIPAVETA
>A0A0Q0RF07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidiplasma cupricumulans|TrEMBL
MINTYKPIYKKQHYGLVGNHSAVKVCHWTKSQLTGHAACYKNTFYGINSHQCIQMTPALN
ACSENCDFCWRFQGFDSMHISQEDDPEFILEESIKAHLKLISGFKGNPKVKKELFEEAQH
PKHMAISLTGEPTLYTRLGELIEAATKRGISTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKKIFNDVLHPAIGNAWENFNRTLEILPSLDTRKVIRHTLVKDVNMPYYDEYEKLDRIA
SPDFIESKGYVHVGQSMDRLAYENMPSHEMVLEFSNELARRLGYTPYADRYESRVAMIAK
DPSKAKIDFEAELKKHMK
>A0A3M7NXN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chaetothyriales sp. CBS 134916|TrEMBL
MDNAENSEWLIYAADWLDRFLAFWHEHRILALGVVVCVTLTTHALVRRRDGAHAVAVRSS
PPSAAETGTWTAEKSPGVAQAGPGRTFSAQTSSKTRPVKVVTGRRPGTKLTAHSSHSPAD
LQLRPIVFYASLTGTTERLAKDVTAQLRLLEPELHDLSYIDLDDYFISGPKAVSSDSQQT
VWPFYVLLIPSYDIDTILNNFLAHLDETHNDFRIDTSPLSILSGYSVFGVGDKEGWPSAE
QGFCYQAIEVDKWMAKLTGRKRAYPLGMGNIKNNIDKSLGEWMSGLCDAINDIAITGTLG
VGVPGSGNAIESDDEAVEDDFPDSGRRKRQKTSQAGPLAIDWTGHSSRSLSTPLKAMVPK
ESPTHAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSC
SNKCVFCWRHGTNPVSTTWRWQVDDARMIFEGAKEGHYKKIKMMRGVPGVRSERFQEAMR
IRHCALSLVGEPIFYPRINEFVRLLHSERISSFLVCNAQHPQQLQSLGRVTQLYVSIDAS
NRDSLRKIDRPLHRDFWERFNACLDIVREKRFLQRTVFRLTLVKGFNVEDEAEGYADLVA
KGLPCFVEIKGVTYCGTSTAAGAGLTMQNVPFYEEVVQFVQALNDALAKRGLQYGIAAEH
EHSCCILLASKRFHIGGKWNTVIDYDRFFDLLEAGQDFRPEDYCEATPEWALWGNGGFDP
RDERVDRKGRKKE
>A0A3M9ZJR0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon S13|TrEMBL
MSCSGEVAEPEGIVQIEGLKAARLRRAKYGISDHGTVGLCHWTKRSFRGRGTCYKHSFYG
ISTHRCMEFSPAGMHCQNRCVYCWRPVEFYDSMAIEAPRAADPEEMMRGLMAERRRLLMG
HYGDAAADSALIDEAQLPSHYAISLSGEPTMYPHLPELIRHLKSLEATKSVFLVTNGQEP
SMIRRLRDEDALPTQLYLSANAADRESFMRINRPRYADSWERWNETLGLLDGIGTRTVIR
VTLIRGHNADAKGHGAFARMLESSGAHFVEAKSYMHVGRSTERLERESMLEMDEVREFAR
GIEVRGPFEFMDESEVSRIVVMRNSRRPIERMIAAYA
>A0A446UNS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRTLRPSPSPSSSPPAAAAAP
TLLYASATGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDD
DDEEEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLEKQ
GYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGE
PIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRP
LFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTY
CGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGK
WHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAAL
KG
>A4WMY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)|TrEMBL
MSCEYEALGRYHLFEGPRIKVRASAGRALIERHYGVAGHATVELCKWTKDALEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDVFLLDERFYMEPEDIVKGVLE
ERRRLLSGYWGHPQGKRRVREALEPTHWAISLSGEPTMYPKLPQLIKLIKSLPSTKSVFL
VTNGQHPDMLRRLWEEDALPTQLYLSTNAPNKELYYKINVPVYNVENAWEKWLESLDLLA
KIPTRTVLRITLIRSLNYDDRYIPEFAQIVKRGSPHFVEVKSYMHLGHSTFRLKKEDMLS
HEEVKEWSHKLLKELEKIGARFVYMDDDEPSRIVVLQNMDRYVERWIVPPQVKIETQS
>A0A7G9YPH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MKPELENLLKKHGYHIAGRHSAVKTCHWSNRAIRGAGSCYKSQFYGVRSHRCIQMTPTLS
CNHRCLHCWRPVEMPVPLPAPTDWDSPVEIKGSIIREHARLISGYGGSETTDMDALREAQ
KPDQVAISLAGEPTLYPYLPELIDLFHKDAMTTFVVSNGTQPDMIAKIAPTQLYLSLNAP
DEDTYLKVCNPCGNFWAEIQESLQVLGRSKMRTRTAVRITLIKGVNMFDPEGYARLLSMC
EPDYIEVKAYMHVGFSQKRLNRAAMPDHEEVRLFASEIGDAVGYRIADDSKISRVVLLSR
DGGVEQIQGRG
>A0A2K3JFW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon M9B2D|TrEMBL
MNPDLQKILQRQHYAIVGKHSGVKLCHWVKQSLLFGRQCYKQTFYGIKSHRCLQMTPAIT
HCTQMCLFCWRFQNFTEKELHDIDDPQYILEYAITAQKKLLTGFKGDPRCDQKKWKEANQ
PNMLACSLSGEPTLYPRLGEFFEACHQKGITTFLVTNGTTPDSLERLDTLPTQLFVSLVA
PTEEIYKKLCAPLIPNGWEKIQRTLSLLPSLDTRTVIRHTLIHGWNMDEKYISAYAKLDS
LASPMFIEPKGYVFVGSSRNRLHFSNMPHHDQIRDFGQKLAEQIGYEQVKEKEDSLVVLL
SPK
>A5E5H9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)|TrEMBL
MGSGNLILSACIATYLLNGGRWSLALCALVLSYIYKHEQQQQQQHQQQQQQGQIQIQVHG
QNLEQDARSVISKPNANFQNLGGKQAFLRKESQNHSSPILAVDFTTSKNFASLNNGPTAE
RTKPFPTRAKRSPKVFKASKPTIEKVGAHLTNSTQVDLKQAQIYIFYTSLTGSSTRIAKK
LCEKLTSLELKHKPKLLSLDDDVDDLEKYFLKTPKNNSETTNGNSEVNEKNIYLMVLPSY
ETDSPIDYFLEHLVDTYQDFRVDKYPLRSLLGFAVLGLGDRESWAGEKFCQQAKLADRWL
GKLGARRLFPAGTVCMKYEGEPKAQEWIQGFAELLVDDEPFYVDENDDAAFDDSDAETEA
SDDADTLVDVEDMGDIIRKTGQIQRQPGSRELEIKQMVTKDSPTYKSLTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNW
RWEVDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFQEAFQVKHCALSLVGEPIFYPHIN
EFVKMLHDQHISSFLVCNAQHPDNLAKLSKVTQLYVSIDAPTKSDLKKVDRPLNSDFWER
LMSCLDILRTTQSHQRTVFRLTLVKGFNMTDIESYADMVERAMPSQIEIKGATFCGSSTG
NGNPLTMQNIPFYEECKNFVQSLNSELHRRGLDYDIAAEHAHSCCILVAHEKFRINGVWH
THIDYAKFFELLESGKDFVDIDYVAPTPEWAIWGSQEAGFNPVDTRWDRKAEKLKNKLAR
EEEAILKEEDLVAEVK
>A0A166E8W1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter curvatus|TrEMBL
MTLNLDEQKKLEYSGYRFAGVNGHAGCKICHWTKKSILNQGECYKQKFYGIESHRCLQMS
PAIPFCYQKCSFCWRDLSHTETKWDGEYDDPKTIIEDSIALHNNLLCGFFGNDKADKKKL
EESKTPNNAAISLAGEPMLYPEIDSLMSEFKRRDFTTFLVTNGLLDEKLRKLENEPTQLY
VSLDAPDEKTYKNLCKPQISGAWDKLNNTLEYLKSFNSKTCIRTTCVKGENMNDPKGYAK
LVNKADPTYVEIKAYMCVGYSRKRLTLDNMPEHQEIINFSQKIADLTNREIINDSEVSRV
VLLK
>A0A847UBC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicrobium mukohataei|TrEMBL
MSESDGPKQVDDPDYHSENHTAAQTCGWTANSLRGEGKCYKYIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPSAVADASLELQKKLLSGFGGNEKVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFHDRDITTFLVSNGTNPDVLAECDPTQLYVSVDAP
DRKTFDDTVKAVEDGAWNSLIDTLDVLADKDDTRTVIRTTLVKGHNMHHPAWYAAMCQRA
DADYVEMKAYMHVGHSRGRLDRDSMPSHDEVRAFTERVGQFLPEHDTLKEVEESHVTLLA
REEETWVPKLEKGSEFWERDPVVSY
>A0A1V5IHW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon ADurb.BinA087|TrEMBL
MPSSPCKALRGQGYQFFSPESSAAVKPCLWCKKALKGGAQCYKHQFYGIESHRCIQMTPT
LRCNHRCLFCWRSFEHEYPGERECTPEEILAGLYDLQKRALSGYKVSPYVTSERFAEALR
PAHIAISLSGEPTLYSHLPELIDLLKAQGFTTFLVSNGTNPDVISQCFPFQTYISLPAPD
QETYLSICRPSADYWERICRSLTLLSTRRSAVRVTLVRGLNDHSPEKYAALFEKSDARYI
EIKGYMYLGYSRKRLNREHMPDHAYIKEFAERIAEYCDYRITNENALSRVILLENRA
>A0A314Y0Q7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus yedoensis var. nudiflora|TrEMBL
MPLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSSSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNGLAFDLVDPNHYEPEDLPKETFVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGASEIFSIWEGDVD
GGDIDEGGVAENGGVLSNGVGAECEAESFDGSDEDDEEEDDVESEVVDLEDIAGKGPSRR
RTVTVTKTNGTVNGKKEMVTPVIRASLVKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKH
SFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAIDLHSKMI
KQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTFLVTNAQFP
EKIKMLKPITQLDAATKESLKAIDRPLFGDFWERFIEKQQRTVYRLTLVKGWNTEDIDAY
YNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPWHADVKAFSEALALKSNGEYEVACEH
VHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSSGRPFDSKDYMAATPSWAVYGAEEGG
FDPYQSRYKKERHHRSNQ
>A0A0V1KFA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSV
HDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIKEMLTP
TLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACAN
KCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESSTVR
HCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASK
ESLKEIDRPLTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCGDSKNSKITMA
NVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNVTIFKINGQWYTWIDYEKFF
SLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A0V1KFR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSV
HDNKRVSVWHDENENSSDAEDAENSANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQGYHL
VGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPV
GTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMY
PHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRD
FWQRLMNSIDILRDKKQRTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCGDS
KNSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWID
YEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A0V1JI83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKRSVNWGRFRLLFRVHQRDFLAGGVVEIQRLYFKNWIAEHIFISFAYKLTTIISFLP
FGIGAIFVENIIIRETNFRQSPFQGGIFGRGILSRYCHCGQLNWISIFQIFFTIINNCII
GHAVFCGNVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSK
FSSVHDNKRVSVWHDENENSSDAEDAENSANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQ
GYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHH
SNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGE
PIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRP
LFRDFWQRLMNSIDILRDKKQRTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTY
CGDSKNSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWY
TWIDYEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>I3JEV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis niloticus|TrEMBL
MPTLIVFILLLASSVSASDSKVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKK
KSVSKDSSKEENDKADKAPKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKALG
LPAEVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSI
QADFLAWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKTSPQNNSSEDD
LVESSSDEDESGLPDEKKTVLDVEDLGNIMNSVKKAKSKEESQRDGQMVKLSKLNGVQKI
EDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGV
KPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPV
TQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQ
AYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACE
HEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYDESGGQQTFSALDYVAKTPSWALF
GAQEQGFDPAETRFQRRNKSKDISGC
>A0A832M0V9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
MSQRLVPDAVKRYLRAGYALMGRHSAVEVCRWTKSALKGGYMCYKRWYGVRSHRCVQMTP
VLNFCNFACVFCWRPHLEGRFEIPAGWQWDEPADIVEGAIHAQRELLAGFKGNPQTAMER
FLEAMYPRHMAISLDGEPALYPKLAELIKEVKARGMTAFLVTNGSVPSRLEELIRKGAEP
TNLYVSVYGPSKEVFEKAAKPLTPRAWELVMETLDLLPKFSARTIIRLTMVKGLNMVDPE
GYAKLIERAQPKFVELKGYTWVGESQKRLPIEAMPTLSELEIFAKRLAELTGYQVKVSDE
KSRVVMLVRDEETWEWNLELVQELRALEEKLDAEWRGKVRDFKIRTLPPPPIPVLTPSDL
KRLASAAA
>A0A1H2Q6A1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula vallismortis|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVRAFTQEMGEYLPNHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWQQDALVEY
>A0A2G9PE87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG09_land_8_20_14_0_10_60_16|TrEMBL
MDFYERYLQSLPRLRKAGYAFVGNRKHSAVKVCLWARRALCGKGSCYKQKFYGIKSHRCL
QMTPAMPSCNQRCLFCWRDTSLFSEAWPLDGADEPSEIIDGAVAAQRLLLIGFKGNASAD
RQKWLEAQEPNQAAISLDGEPTMYPKLAELIREFHRRGFTTFLVTNGTRPEALRHLAAED
ALPTQLYVSLCAPDEETYEKTNLPVGDDNWTKLNETLMLLPSLATRKVLRLTLVKGLNFH
SPERYAKLVKVSGVDYVECKSYMNVGFSTQRLTQAHMPSHDEIRAFAAELAGNAGYEFTD
EQVESRVVLLSRDAEAARNRFITRV
>A0A1G4KAK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea mirantina|TrEMBL
MLDILLTCTAIAAYMLDGGRISVGCFLLTIVCLAKHDASSSVSDVKRGEDEGVKSTEKKT
CCGGSNGQCCSSKKGSKGGCCGGACSSKKSKTVSVKPSATIESNNLATDFTEAFKSPNAS
KSGPMKKRMPRIISKTGKGSGIKAAKNQQSFFKKALTISKGKLIGSQIYIFYSSLQGAAE
RSAKLLSGVLSEIKDLKHSPVILNIDELADFDDYFVNVPTENSLYFLVLPSYETDSPIDY
FLQTLEENAEDFRVDKYPLRKLVGYSVLGLGDFETWPEKFCYQAKTADCLMAKLGGRRVF
PVGEACMKYDGDAKITRWAQLLAKTLQDDEPILYEYNETFDDDEVAEINQKETLGDLEDF
GKLSELPNTGEMKKMISKDSPTYKNLTKQGYTVVGSHSGVKICRWTKSDLRGRGSCYKHS
LFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDDPEYILENALQGHYSKIK
QLRGVPGVIAERFAKAFEVRHCALSLVGEPIMYPFISRFVELLHEKGISSFLVCNAQHPE
PLRDLGKVTQLYVSIDAPTKMELKKVDRPLYRDFWERMLECLEILKTTQSHQRTVFRLTL
VKGFNMTEVKAYADLVEKGKPCFIEVKGATFCGSSDGNGNPLTMQNIPFYEECTNFVKAL
SSELQQRGLGYDVAAEHAHSNCILIANTIFRIDGKWHTHIDFDKFFELLKSGGTFSHLDY
IKETPEWALFGNGGFAPGNTRFYRKGKKPAQDIKTEAVKVAEVSA
>A0A818Z8A6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood1|TrEMBL
MTVDLYIFAAGTALTGLVFYYLAGAEWSLWHLFTIPLYTFIFIVFLSLSILKRFKTQLST
KIISQDKNGITIVFGSVKGNSRTFAQLTYDKLLNELNRQVILQDLNDITDPEEFLQIQVK
NQRILLIFISTYEDGIPPPSAKWFLRYLQEAATDFRVSKNELEKLTYTIFGCGNSLYNDN
FNKVAKELDRCLLELSAKQFIPSEYADENTVKSIYGGLEGHYSKWLSQLISNLQSSKVDK
CDCSNDKSINCCQSLTNNNHSNENVEQLRIESDDDDEDGGGCKNGNDDIMDLEDMGDYME
THSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENHYKMINTF
KGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHSKKISSFLVTNAQFPNEM
KTLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLDSLRALKDKGQRTVYRLTLVKGY
NTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASHLTMANVPWHEEVVTFVKLLCDRLPQ
YDVACEHEHSNCLLLANKKFCIDGKWYTWIDYERFHELVTRHKVTSGAETFTSVDYMAIT
PDWAVVGSNERGFDPTDTRWYRKATAKKNLSGC
>X0JR47|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. conglutinans race 2 54008|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>H0GPC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNESTATEVEKAVNYPVTVDFTEVFKKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A7J9PFF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPEQIHNILRKQHYQLKDHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLESFESPEWKEPEIVAEDILNMHKTIITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYQKICGGTKENWESILNTLDILDSKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRNRLNLDDMVKQFELLDMGKLLEENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A420HPH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Golovinomyces cichoracearum|TrEMBL
MNSAGWNFKNFWSQETKTNRGQHSNSVDPVELWHIHRFSIFLIILTIFVSLKLLFYFRAT
RENHPSTASNPKIISVEDSKKSSEKDQTSVQGRVPKRIVGGLKKSRVSPTTENVSNQKIS
VLIFYSSVTGTTKKIAQDFTESLARSSEKLDNFGRNIFLKPELIDLAQIVFEDYFLNFGP
SNPNVRHFYLFLLPTYNIETILDSFLEHLLETHNDFRIETAPLSPILGYSVFGFGDQDGW
PTEKDGFCSQAIEVDKWMARLTGGKRAFPLGMGDSKINATENLEKWKEGIEDILRHIAST
GSLGEGVIGSGDAEESDLEETDDDQGSDRKLNQSHRTKKRIEKKDIQNDLEDIGSTVNNK
STDNSPQEINFTHYGLKSPPIIKEMVPKGSPTHKALTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELIFNG
VKAGHYQKIKMMRGVPGVRSERFSEAMRIRHCALSLVGEPIFYPYINEFLTMLHAEHISS
FLVCNAQHPDQLASLKPVTQLYVSIDASNRESLRKIDRPLHHDFWERFNRCLDILRQRRF
EQRTVFRLTLVKGFNIEDEIVGYADLIEKSLPCFVEIKGVTYCGTSSAAGAGLTMQNVPF
YDEICTFVESLDKELNRRGLDYGIAAEHAHSCCVLIASKRFQKHGKWHTRIDYDNFFRCL
ESGEKFRPEDYMGLETPEWATWGNGGFDPRDERVFRKGKNKVPLSLIDPKIGALSIEQ
>A0A3Q2U4B6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gallus gallus|TrEMBL
MAGGLDVSMDTWNFVYACLVSLWLHRIYIYSVTAFGISLWIAVQFFTTKAKRKDEHSNGN
LVSSEVVEDKLVNGYATLQPKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVTCFNLPVEVI
SMGDYDPDDCLAEETTSKNICVFLVATYTDGKPTESAAWFCKWLEETSNDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFEA
WKSKFLNCLQALCRGEKKPCSGKCKKGKCKSQGKPSKESSNPERGAPEFENTETEELFET
TSEEEADAEEAGGTDSVVDVEDLGKIMSHMKKAKRERELEDGDAGMSLLGETSGRKEAGE
RREMITAALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREALENHRNMIKEFKGVTGVRAERL
EEAMTTKHCALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLYV
SVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKGVTYCGDSSASSLTMANVPWHEEVV
HFVQELAQLLPDYGIACEHEHSNCLLIAHKKFKINGHWCTWIDYERFQELVRAHVDSGGT
QTFTATDYTARTPHWALFGSNQLGFDPLDVRYQRRGKVRDISGC
>A0A8B7YWY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acanthaster planci|TrEMBL
MAASISNCNCVVFCTIFLLFCGRNNVFADENRSEDDTLSSSQISWGSKLVTKLWTSAPCW
YGVTFVTGVATLLLVIIWWNRNENEDQNVHVHMPDAAPARRPAEGRHQSPRPAMGGISQS
RKKPVATGAAAANQNGDVTGRHQGLTSSPKHRLRILYGTQTGTAKHFAEDLAKQVASTGN
AAEVVDLKTFDPESHILPETDGLVTCVLIVATYSEGKPTESAAWFCRWLEEATTDFRVHK
SLLRGLKYAVFGLGNSLYEGHYNQVARDVDRWLSTLSASAIVARGEGDQNVAESKHGGIE
ADFEAWKTLLLQTLASNASICCSTEKQTCECGKTEGGCRQATEKESRNADKEEMYDSSSE
DDNCDDDFIDDGSGDAKSKITQTNGLTDLEDLGKVMKKMKKAKESKASDKASEPREMITP
MLRQALSKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDEPEAILKDALKNHYQLIKQFKGVPGVKPERMAEAMNVQ
HCALSLVGEPIMYPEINRFAKLLHSHKISTFLVTNAQFPDAIRSMVPVTQLYVSVDASTK
ESLKKIDRPLFRDFWPRFLSSLEALSEKGQRTVYRLTIVNGWNNEEIEAYANLVSIGKPD
FIEVKGVTYCGESKASTLTMKNIPWHEEVVGFVQKLVDLLPDYAIASEHEHSNCVLAAHK
KFKKDDEWWTWINYSRFHELIAEYEASDGERRFTAADYMSKTPAWAVFGCKEQGFDPSET
RFRRKGKNKDISGC
>A0A1L9V440|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus glaucus CBS 516.65|TrEMBL
MDCSSAMLEGVVTFWHAYRLPILITLSTLFVIVQAYRKLQPKSKTEASSSLPPSPRSHSP
EKSEKIPVSDGTKKETPVVSKSTGPKVVTGKKPVKGGKRGGSDEAPPLSFIQPIVFFASL
TGTTERYAHMLVEELRAAAQNRADPENRERGLLPPQLHDLAYIDLDDFFTSAPKPPSTSP
GTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTGSLSQLAGFSVFGFGDKEGWPTE
EEGYCSQAKELDRWMAKLTGKRRAFPLGLGDVKDNAEQALKEWSHGLQDILYDILQNGGL
GEGVPGSGDPLESDEEDVDDEDETDVAKPKSKRGKGQSQSVVDLEDIKVNPDSPAPLAVD
FTTGGKSSESQAKEMVPKTSPTYASLTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFS
FYGIKSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDDPDMIFDGVKDGHYKKIK
MLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDLLHSERISSFLVCNAQHPD
QLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRNVQRTVFRLTL
VKGFNVEDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEEITEFVLA
LNEELERRGLNYGLAAEHAHSCCVLLASDRFHVNGKWNTRINYGRFFELLEKEKADGTSF
TPEDYMDETTEWALWGNGGFDPNDERVYRKGKKAKAQKELASSTANE
>A0A8H5NT34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium pseudoanthophilum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVVLVAIRTYFHINGQKTEIVAFKKV
YEEPVKPKVVEEKAPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKGEEKDITRPVAPLV
FFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGHG
DADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPTE
ADGFCFQAMEIDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGSL
GEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDGS
ITQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRWT
KSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEL
IFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHAE
RISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDILR
EKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKKF
FELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A3M6ZME7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDLEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGVKKSKSAASQEAQVIERIQPI
IFYYTLGGSTKVYAESVAQDLTTSSPSSILEPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKDEAEVMLKEWTEGVSSIMKDLADGKGLGEGVP
GSGEPIESADEASEDEDETPAPRKTKRKPAKRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHR
>A0A5N6KS08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Carpinus fangiana|TrEMBL
MTVWEAPPGAVRSSGRHVHSMETVLQLWHDYRIPAGLLVGLVLLLWRLAGTRRGKSSENP
EAVRERALDIPEVFKQPTKQTPRDPEKPVRHIASTQAAVAIGPRKIKGQKTTRRPSPQRR
QDTPLQVQPLVFFSSLGGSTEKYAGDLLKTLPSALTTAAPSASNIRAPQLLDLSYIEYED
YFTGLPKSDESIAYVYLILLPTYNIDTNLSNFLEHLQETHYDFRVDTASLSGILGYSVFG
FGDREGWPTEAEGFCSQAKEVDKWMAKLTARRRAYPLGMGDVKSDLKQRLGEWQSGIVDV
IIDLAAGGSLGEGVPGSGNAVESDEEDDELDGQSRKPPDLADLETLGGNMDSEEPLAVDF
TTYGRMQSSKPAQPAPSAPKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDQPDVIFNGVKA
GHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPYINEFTGMLHAERISSFLV
CNAQHPDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCRCLDILKEKRFRQR
TVFRLTLVKGFNIDDEAEGYADLVERGLPCLVEVKGVTYCGTSSSAGAGLTMQNVPFYEE
VCAFVKALNAALERRGLKYGIAAEHAHSCCILLAATERFFVGGKWHTVIDYERFFERLES
GDPFAPEDYMAPTPEWALWGNGGFDPADQRVDRKGRPKVVEI
>E9EYG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)|TrEMBL
MSAVCEKTDPLQGVFGGLPGAKFDDIVELWHGHRTPIIICALVVLVVIRIYIHKIEEAEP
LRALPKRFEKRIEPLSANKLPSAVNSEKPIAKPNGPRRIKGGITKKPATEETKEYDKSRP
IKTMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFFVSP
AKTVEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFGDKE
GWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVQEVIAHVA
SSGTLGEGAPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRMLRT
SDGNGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSIVGS
HSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHI
NEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTS
TSSNAGLSMSNVPFYWEVCEFVKALEERLKAKGLKYGIAAEHAHSCCILLASERFLVNGK
WHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIEN
VVVREAPPPDSW
>A0A0K9PV97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zostera marina|TrEMBL
MTTNMFVSSLPSRLALFALLSFSTSVFLFRKSRRLRKQRLTVKEINIPNLTTPLRKPKLF
FASQTGTSEALARNLHVLLASNGIDFDLVDPRSYEPEDLPKESLVLIVVSTWDDGNPPPS
MGFLYQWLSESTEDFRIGKSILSRCKFAAFGVGSRSYGEERFNAAAKGFSRWMRALGAME
MVGVGVGDVDEGDVNEIFEKWSGDVVAFLMGDGVLRENGRVVVNSESEDDQLYDDDSDQE
SDVESDVVDLEDIAGKGPTRKSGVVKENGEKDAKTNGLRDMVTPVIMTSLQKQGYKIIGS
HSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKE
WRWKMDDPIEIVNSALDEHKKMIKQMKGVPGVKQERLLEGLSPRHCALSLVGEPIMYPEI
NTVIDELHKRRISTFLVTNAQFPDKIKFLRPITQLYVSVDAATKDSLKAIDRPLFSDFWE
RFVDSLKSLHGKQQRTVYRLTLVKGWNAEDIDAYSNLLDIGQPDLIEIKGVTYCGSTSTS
SITMKNVPWHEDVKEFSEALAMKSGGKYEVACEHAHSVCVLLAKVDDFKINGQWYTWIDY
EKFHNLVASGKPFKTKDYMSQTPSWATYGAEEGGFDPDQIRYKKERRHGSKTLPN
>A0A167FVT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Beauveria brongniartii RCEF 3172|TrEMBL
MDPLSGANGQSALFNINGLLDVWHTNRTPIILLALCGLVVLRLYIHAYKEKPDLKIIPKI
YENAAYKNVAYKKSDNVSPPLVQEKTAVKTVGPRRIKGGVTKKPETTEELIDLNKPVKVL
VFFSSITTKTEKIGQDYIAKLEKSVAQLAAETARPILAPELLDLTEIDFDDYFIAPPKSD
DGAQFLYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLMGYSVFGFGDREGWPD
EAEGYCFQAKEVDKWMAKLTARKRAYPVGMGDMKSDHAERFSEWSSGVEEVFSQIIRTGY
LGQGVAGSGAPVESDDELEEDYDDGEVVFDDEKPSKRENGKSSSNLDDVEDLGRVIKSQG
GDANPKAPIAVDFTTYNNKSNPQNKVKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEL
IFDGVKENHYKKIKMMRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKE
RISSFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILR
EKRFRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLTMS
NVPFYWEVCEFVRALDRRLQEKGLAYGIAAEHAHSCCVLLASERFHVDGKWHTHIDYDRF
FELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVVREAPE
>A0A0C9MQ92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor ambiguus|TrEMBL
MSNFINSLLYGFTNILSVGPEQPREGQENEGGCSGSNGEGCCKDTPQEPKAKSGCCQGDS
AGDACCTSSAEPAAVETKKEDGCCQSTPGKSSCACESASNEPVIIDNLKIIFSTLTGTAK
TMATDIENKINANERVTVNKIEIMDVTEYDNDNLLQETAVCVFILSTYNVEGPLDWFSNW
LHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAANIDKWLGRLGATRIYPLGECD
KNADQKGQFDVWSNGFVSELEDKHSLEFSPTNIAFQSDDEDDEASAEEEEQQPDIDIDGS
GSGDEMVDLEDMGNMASKIKAAKAKRAEEEEDFENSKAKAKRLIGTDVGNKPKTAPQARE
MVSPMILKNLTKQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSL
ACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQFKGVPGVKAERFQEA
FTIRHCALSLVGEPIFYPHINEFVTKLHENNISSFLVTNAQFPDKIAEMVPVTQLYVSVD
AATKDSLKKIDRPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAEIDGYVELIRR
GKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCQKLVSKLDGDYEISAEHAHSCSL
LIAHKDFKVNGEWHTHIDYPKFFELVKSGKPFNSLDYMAKTPEWALHGHEAAGFDPNETR
HYRKNRKTVVPPVNADINAA
>A0A8C2Z9P3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyclopterus lumpus|TrEMBL
PVSQNALSPSESYLMSVWHNRLYLYSAAALVFGIWFSVKVALKKGFAEELSEEVKTLGVP
AKVIDIRDYDPDDQLADECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKT
YLKGLPYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSAVRIMTRGEGDCDVVKSRHGSIQA
DFLAWKVKFLIRLQALVKGEKKSYSGNCKTKGSCKNPKKDGQEEEEETTALQNSSEDELV
ESSSDEEESGLQDEEKSGSVVDMEDLGNIMSSAKRAKRLTLFKIIFIIIFNRMHKLHERC
LFSVDQSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPAEKILHEAMEKHQGMIRQFRGVPGVQPERYEEGLAVKHCALSLVGEPIMYPEINAFIC
LLHSHRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTRDSLKKIDRPLFKDFWPRFLDS
LRALGEKRQRTVYRLTLVKAWNVEEMLSYSELIALGQPDFIEVKGVTYCGESAASTLTMA
NVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQDLV
QVQGESGGQRGFSALDYMAKTPSWALFGANEQGFDPTDTRFQRRNKTKDISGC
>A0A319BRG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus vadensis (strain CBS 113365 / IMI 142717 / IBT 24658)|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKIISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGSLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKRNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAAEAQG
>A0A8C9QXW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
MFLLVTLQLLAASLHAFAADTDGVSEEGWSSSDYLLWMWQSRWYGYCAGALLFALWLTVN
TAREKKNAVQLANSTQHKIVKANGYLVEKEQKIYVSGVKIFFGSQTGTAKGFARNLAEDL
HALDLIAEVIDLKDYDPEDSLSDECTSKAICVFLLATYTDGLPTENAEWFCKWLEEASTD
FRYGQTYLKGMRYAVFGLGNSVYTGHYNTVSKNVDKWLWMLSAARILTRGEGDANVVKSR
HGSLEADFGSWKARLLKRLEALVRGEKKACSGKCKKGTCKSKGKGKVLEQSEHHSSEEQL
METSSDAESATGEEADHRSVVDMEDLGNVMNLMRKAKDEVEDSRQELKRRKSEEEEHREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDPPEIILQEALQNHQNMIKQFRGVPGVRPERFEEGL
TAKHCALSLVGEPIMYPEINAFIRLLHRQRISSFLVTNAQFPEEIRSLVPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLKALGEKQQRTVYRLTLVKAWNVDELKAYADLISLG
QPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRQLADLLPDYDIASEHEHSNCLLI
AHRKFNVEGQWWTWIDYERFQEFAQLYEESGGQRTFSAEDYMARTPDWALFGAKERGFDP
ADTRFQRKNKTKDISGC
>A0A0S3RQD8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vigna angularis var. angularis|TrEMBL
MSISNSLSSVPARLTLLALFSATTFYCLYKSRRLRYLKLSLNPNPKPKPKIIFLSETGTS
KTLALRLHRLLASNGVAFDVVDSRHYEPEDLPKETLLILIASTWQDGAPPAASRFFATWL
AEAAADFRAGSLLLSSCRVAVFGVGSRAYGESFNAVAKGLATHLRALGSKEVVPLCEGDV
DGGDLDKVFDRWCEKVLAVLKGGGVAECDDGDGGGALECGVYSSSEEESDVESEIVDLED
IAGKAPSRRKTLASGEESNGKLSGRKEMVTPVIRANLVKQGYKIIGSHSGVKICRWTKAQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPREIVN
SAIDLHTNMVKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINALVDELHKRRIS
TFLVTNAQFPEKIKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALREKH
QRTVYRLTLVKGWNTEDVDAYSKLFSIGDPDFVEIKGVTYCGSSTTSKLTMENVPWHADV
KAFSEALALKSQGEYEVACEHAHSCCVLLAKTNKFKIDGRWYTWIDYEKFHDLVASGKTF
DSRDYMTATPSWAIYGSKEGGFDPGQSRFRKERHHKSSHNQLGLVPFQCI
>A0A498FZP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. Atlit-7R|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNNEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMSEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A094FYJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4518|TrEMBL
MANNDYLGADIASDAMENYLMVLWHTYRIPLILTALALLLITRTVLHLKVGREKIIYTPP
PTPSEKAPLATNLQREQLVEKAPVSAEVKKAAGPKRVVGKVTRKKSPLRDQTASKDVKFQ
VLVFYSTLAGSTERTAQTLTTKLADTLKASAESSQYEFLSPIAHDLAELEDYDEYFLNVP
KSEDGEPDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGD
REGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQEQLDEWRQGVEDVLQN
LGQTGNLGEGVVGSGDADESDVEDADEDEAEVQSDGAVKLKRKSKKKATSSMDDVEDIGR
ILQKGQKESEDQDEEAIDFTTYGKKTPKPVAALKEMVPKGSPTYNALTKQGYTIVGSHSG
VKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRW
VVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNEF
TAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQ
RCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSG
AAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWHT
RIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEGE
EAEPKEVETKEDKPVLVEI
>R9XGS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ashbya aceri|TrEMBL
MCGANSETEELFLTGVPGWVVLASVLVSYIGTGGRVSIACVVTTLYFLANVEATKNASFA
AALGAPVKPKGKGCCGGKNGGCCSNKTAPKPKGHKCSCSGSKGAKAKAVLKKASAAASGQ
EETFPIAIDFTNSFKAPQSKVAPVKKAPKVISGLAKKKEKDAFIKSGLTISNEKLLASQI
YIFYSSLQGAAKRSAELVLGELRNLKPLELEPILLNLDEIDDLDKYFVDVPCENALYVFV
LPSYDSDSPLDLFLETLEENFNDFRIDKYPLRKLVGYAILGIGDSEMWPEKFCYQAREAD
LSIAKLGGRRIYPVGEVCVKFGGDPKVEEWARLFVDTLQDDEPMLYEYDESVEDELDDSS
ETAVEALVDLEDIGKGSGTDSTGNLKKMVAKDSPTYKNLTKQGYSIVGSHSGVKICRWTK
NDLRGRGSCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVAKNWRWELDEPEFI
LENALKEHYSKIKQMRGVPGVIAERFAKAFQVAHCALSLVGEPILYPYITKFIELLHQKN
ISSFLVCNAQHPDQLEALGKVTQLYVSIDAPTKTELKRVDRPLYKDFWERLMRCLELLRT
SQAHQRTVFRLTLVKGFNMADVSSYADLVQKGVPCFIEVKGATFCGSSDGNGNPLTMQNI
PFYEECVSFVKEFVAELQKRGLTYDIAAEHAHSNTVLIAHTKFKRGDKWYTHIDFEEFFR
LLNSGASFTHMDYMTETPEWALFGNGGFAPGNTRFYKKKNKKNEASVPEVKVA
>M0LT78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobiforma nitratireducens JCM 10879|TrEMBL
MSDSDGSPSQPSQVDSPDYHSENHTAAQTCGWTANALRGEGKCYKNIWYGIESHRCIQMT
PVVKCNERCVFCWRDHQGHAYELDDVEWDDPEAVVDASIELQKKLLSGFGGNDEVPREVF
EEAMEPRHVAISLDGEPTLYPYLPELIEAFHERDITTFLVSNGTNPDVLRECEPTQLYVS
VDAPERHTFDEVVKAVEDDAWERHLETMDVLADKDETRTVLRTTLIKGENMHHPDWYAGF
YGQADPDFVELKAYMHVGHSRGRLDRSSMPDHEEVAAFARSVGEHMPEFTEIKEVPPSRV
ALLSKTGDTWVPKLKKDSEFWERDSVTGTADD
>A0A147BHJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ixodes ricinus|TrEMBL
MIEIVLCIVFAAPANGREVVSEHWTSGWLPSSFATTLCGGVVMVLFFVVVREKFKFSKIQ
SDSHVKKKKKNPDGRSIKILYGTQTGNAKILSEKLLAELEALNHDVEIVNLKHIEPEECL
LGQVKSKGLCIFIVSTYVDGGPPDEAVWFYDWLKDTYADFRVHKYFLQGLDYAIYGLGDS
AFNDNYNKVARDIDFWLSKLHARRVVPLCLNDESVDEGKYGTGKFGAWKSELLAQLRLGA
KGAAQFDAPEEKPTAYETSSDEEGGGDLIDLEDLGTVRIASKNKAKAEGAAGQPKDMLTP
PVRESLTKQGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIDSHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWKWNMDPPEMILDAALESHYKMIKEFKGVPGVLRERLAEGLAVR
HCALSLVGEPIMYPEIGRLVRLLHARGVSTFLVTNAQFPEALEALGPVTQLYVSVDASSR
EALKRIDRPLFPDFWQRFQDSLTALARKGQRTVYRLTLVKEWNMAEMQGYANLVELGKPD
FIEVKGVTFCGESKGSSLTMGNIPWHEEVLSFVERLAALLPDYSIASEHEHSNCVLLAHH
KFRMDGVWHTWIDYEKFHELVQRHYESGEPFGSLDYAAPLPPWATFGARERGFDPNDTRM
LRRSRKDVGGC
>A0A662MSQ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococci archaeon|TrEMBL
MSEINMPEEIANLFKKQHYALVGHHSGVKLCHWLKESIKHDRVCYKQKFYGIHSHRCLQM
TPVLAWCTHNCIFCWRPMEGFLGVELPKPWDDPSLIVEESIKAQRKLLTGYGGVDNINKK
KLQEAQEPKHAAISLSGEPMLYPMIGDLVEEFHKRGITTFIVTNGTAPERLEEMIKEDKL
PTQFYVSLTAPDEETYNRVNVPMIPDGWERINNTLELMNGLPTRTVIRLTLVKDENMHNP
EGYAKFIMKAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIRAFAEELVKYLPGYHIEDE
YVPSRVVLIMRDDVSRENRFIKH
>A0A2H5V8G8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon HR04|TrEMBL
MSCADEHVQDLIQIKPSIARQLRNAKYGVYNHSTVELCHWTKKSFMDEGTCYKHRFYGID
THRCMEFSPAGMFCENRCIYCWRPMEFYEHIEMPGDAVDEPQAIIDNLMSERFRLMSGYF
GNADANKAKLIEAMRPTHYAISLSGEPTMYPKLPGLIRYLKSLKDTRSIFLVTNGQEPEM
LYRLEEEDALPTQIYLSTNAPNKRLYYLINKPRLRDAWERWLKSLEFIASTNARTVARIT
LIRGYNYGLDTAREFAEILRIGNPHFIEVKSYMHVGNSINRLSADAMLNMDEVLAFTGVL
EHHLDDYAIYDWSIPSRVAVLQNMKRYVDPIIR
>A0A101EMK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sibiricus|TrEMBL
MDVKPNMPEEITNLFKKQHYALVGHHSSVKLCHWLKESIKNNRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPKPFDDPAFIVEESVKAQRKLLSGYWGVKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEVEVLEKMMKEN
KLPKQLYISLTAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMH
NPEGYAKLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVKNLPGYHIE
DEYPPSRVVLIMRDDLKKADRVIRH
>A0A1B8ELN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. 05NY08|TrEMBL
MANNEYFGADIASHASENYFIALWHTYRIPLILTLLAVLLITRTVLHLKVGREKIVYTPP
PTPSEKAPVAANPQRGQLVEKAPILAEVKKAGPKRVVGKVTRKKSPLRDQPANKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLAPIAHDLAELEDYDEYFLGLPK
PEDASQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQDRLEEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEEAEEDDVEVQSDGAVKLKRKSKKKVASSMDDVEDIGRI
LQKGQTESEEQDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
GAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEG
GEAEVKEETKPTLVEI
>A0A015LQQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis (strain DAOM 197198w)|TrEMBL
MKFAIFGLGDSAYGDQFCIQPRNIDKWLGQLGAKRLYPLGEGDKNSDQEKNFEAWKKSLV
DMLFDPSYALNNVSSNLNYDSYSESDSDSDNNNNSDTEMVDVEDIGALAPKLQAARKSKE
EEEFVYKNSNGRPKRTLSEQEVPINEPKEMVTPMLRKSLTKQGYKVVGSHSGVKICRWTK
SALRGRGSCYKFCFYGIQSHRCLETTPSLACSNKCVFCWRHHTNPVGKEFVWKVDPPEMI
FSECLSNHYKMINEMKGIPGIRADRFQEAFNVRHCALSLVGEPILYPHINEFIKLLHDRH
ISSFMVCNAQHPSRLRALDKVTQLYVSVDASTKESLKKIDRPLFKDFWERFLECLDILSQ
KGQRTVYRLTLVKDYNTEEIANYVELVRRGKPDFIEVKGVTYCGYGGASKLTMANVPYHN
EVISFVKHLNENLGDTYEIATEHSHSCSILIANTKFKINNKWYTWIDYDKFFELLEKGEH
FTSLDYIAPTPSWALFGSPEAGFNPEDQRFYRKSKKNNNSVKNGGC
>A0A0A5IDK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paracoccidioides brasiliensis (strain Pb03)|TrEMBL
MTGIVLGISPPGLLSLWHKYRIPILFLAPVVLAVVRLLPKYPTSDPPHSSGSSPLPSSKE
TINSGDVQERELLLSKTEPPWATLTKHDPSPSSSPDSDKRTKRRLNGPKRVHGTKPLKND
VNRLSGHARLRLDIVIQPLVFYASLTGSTEAYAKSFCDRLQGAAQSSRNNGNGTFLAPKL
HDLSYIEFDDYFIAAPNPTDSAPNTKFFYCILIPTYNIDTMINTFLDHLNETHNDFRINT
SSLSGLIGYSVFGFGDGEGWPTEEAGFCSQAKEVDRWMAKLTGKKRAYPLGLADVKDENL
QIILSDWCDGLSDVLSDMVALGGGLGEGVPGSGDPIESDEEEDIDGEPAENKTNGGNRLK
KDQEQQPIVDMEDIKFTISDEKTSADSQLLPIDFTMQSGTQSFKPAAQLEMVPTSSPTHA
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWRADPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINKFLELLHGEQISSFLVCNAQHPDQLATLDRVTQLYVSIDASNRESLR
KIDRPLHRDFWERFQRCIAILREKRYFQRTVYRLTLVKGFNVDEEVVGYADLVEKGLPCF
VEVKGVTFCGTSTSARAGLTMKNVPFYEEVVSFVVALNAELSRRGLGYGIAAEHSHSCCI
LLASNRFFVNDRWHTRIDYDKFFILLQREKSDGIQFRPEDYMRETEGWALWGNGGFDPND
TRVYTRGKNKAKQNATIEESLAQGASVNG
>A0A6I9JDY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chrysochloris asiatica|TrEMBL
MVAVYRPRGRRTWADPSPGLRPPSLRCNDSAAAARQRSAVEAKSRGISLLARGHSSLDNW
DFSPLVSLWINRFYIYLGFAFGISLWICVQIVIKKQDKNSQEKSVPRVSWDLMTNDSDSC
PKKEVFVSGVKIFYGSQTGTAKGFAAILGEAVASLDLPVTITNLKDYDPEDHLLEEATSK
TVCAFLVATYTDGQPPESAEWFCRWLEEAASDFRFGRTYLKGLRYAVFGLGNSAYTSHFN
KVGRNVDRCLWLLGARRVLSRGEGDCDVARSRHGSIEADFSAWKTELTSRLQELRQGHKR
LCGSNCQKGKRGSSGQHGTDRREGSPHRGAEVEEPLENSSEEECGPEARQSLNPVLDVED
LGDIVDRMKKEKRETEQWKEKSRLLGSVGKKADSERRTMITPALRDALTKQGYQLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKMDQPDMILQEAIENHQNMIKQFKGVPGVRAERFEEGMSVKHCALSLVGEPIMYPEINR
FLVLLHQHKISSFLVTNAQFPEEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRF
LDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAHLVSLGNPDFIEVKGVTYCGESSASSL
TMANVPWHEEVVRFVHELVDLLPDYGVACEHEHSNCLLIAHKKFKIDTEWWTWIDYQRFQ
ELIQEYENSGGSKTFSAKDYMAKTPQWALFGAHERGFDPKDTRYQRKNRSKDISGC
>A0A2R6JJS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_8_69_26|TrEMBL
MPKQVDEPDYHSENHTAAQTCGWTENALKGDGKCYKKVFYGIESHRCVQMTPVVKCNERC
VFCWRDHQGHAYELGDVEWDDPDAVAEASVELQRTLLSGFGGNEEVPRERFEASREPRHV
AISLDGEPTLYPYLPELIEAFHDRGMTTFLVSNGTNPDVLAECEPTQLYVSVDAADRATF
DRVVRPVEDDAWEKLVETMDVLHGKDSRTVIRTTCMDGWNMDHPAAYAGMIRRADPDFVE
LKAYMHVGHSQSRLDRGVMPDHERVREFATDLLEHLPEHDTVKEVPRSRVVLLARDEDTW
VPKLRKDSEFWAGDAHA
>A0A1V4YD80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. PtaU1.Bin097|TrEMBL
MPLTIHDFRDLEKKGYRFVGSKNHAAAKICHWTKKSIVGEGVCYKEKFYGIESHRCLQMS
PSISFCHHKCLFCWRDISITETEWNEEYDEPADIIDGCIEAQRNLLCGFFGNPQSDPKKL
AECKEPNNAAISLAGEPMLYPLIDDLLAEFKRRDFTTFLVSNGLSPSRLENLEVEPTQLY
ISLDAPTQEIYRGLCHPQVENGWEKLNESLDMLSSFNSRTVIRMTCVKDYNMSHPEEYAR
LIERSNPDFVEIKAYMYVGNSRKRLEFSNMPRNQDIYNFASSIAELCGREIVNESRESRV
VLLE
>A0A7J3QGA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MRWEKDSERLERAGYRIVGRHSAVKVCHWTKRSLLDRGVCYKEEFYWKELGVRSHLCLQM
TPSIWFCDHRCLHCWRDTSVTVGGWEGEADDPSLILDLAVEAQRSLLSGFGGNPAVNRRK
LEEAKNPRHCAISLAGEPTLYPRIGDLIEECRRRGMTSFLVSNGMHPEVLERVPCPSQLY
ISLLAPDEETYRRVCMPLIPDGWERLLRSLEILRRIGGRTAVRVTLVKGLNMFNAKGYSS
LILRGEPDFVEVKGYMWVGYSRSRLKLENMPSHADVMEFAEQIARETGYEVAGEHQASRV
VLLRP
>A0A1V4Z4N8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon PtaU1.Bin030|TrEMBL
MTDDMNRAREKQQYKMHGGHAAVKLCHWMQQSLLKGRPCYKEEFYGIRSHRCLQMTPVVN
QCSHNCLFCWRVQGFEGSVERWSEPEAMLDACIDEQRKLVSGFGGDERCSREMWKEAREP
RQVAISLSGEPTLYPYLGDFIELCHRRGMTTFLVTNGTYPEVLEKLHPLPTQLYVTVAAP
NVEVYRRLCVPRQQDGWERLMRTLELLPSLETRTVIRHTLVKGWNMGWEDEYARLDSIAD
PLLIEPKGYVFVGDSRRRMHMDNMPSHTDIVEFSRRLGERLGMDTLKERRDSRVLVLGRD
DSQLRIPGL
>A0A7J4AWV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLETLVPSTLLQALKKQKYHLIGKHSAVKRCKWLYETLVHDRACYKQKFYGIKSHQCIQM
TPSLFYCTQQCLFCWRAQSGDLKIKWDEMRLPNWDSPEEIFQGSLKIQAKLLSGYKGNAN
TNWKKLIEAFSPRHVAISLTGEPTLYDPIGELIHLFHNKGFTTFLVSNGTMPAKLANLSE
EPTQLYISVCAPNEKVFKQVCRPHFSDAWARLNESLSLLASFRCPTVIRMTLVNGLNMTA
VEEYAELVKKANPTYVEVKAYMHIGFSNLRLSYEHMPKHKDVYNFGTLLAEKTGYKIIDE
AIESRVVLLSKLEKPIRFGFL
>A0A832BWR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPDALIEALKKHRYHLVGRHSAVKRCKWLYESLVHGRPCYKQKFYGIKTHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETKLPTWDTPEEIVEGSIKAQLAILSGYKGNPKAD
PQKFREALRPRHAAISLTGEPTLYEPIGELIHAFHKRGFTTFLVSNGTVPFALANLSHEP
TQLYVSVCAPNKEIHKKVCRPILPDAWEKLNETLELLQSFSCPTVMRITAVRGLNMGNIE
EYAKLIEKANPTYVEPKAYMHVGFSRLRLGYGSMPSHEEVREFALQLAKATGYKVIDESE
ESRVVLLSRLEKPIKFSSS
>A0A550HG28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQTSSSEHRLYKENSSSTSNINSNLLRVLKKQKYQIIGNHSAVKKCRWLHMSLVEGRSCY
KSKFYGIKSHRCIQFTPSAIWCTQSCLHCWRIQTGESNLSWDESTSEIWDTPSKIVDLAI
ASQKKILSGYKSQVLSGKIKSDVYQEALKPKHVAISLAGEPTLYPDLGALISEFHSLGMT
TFLVTNGTRPDVLKNLSDEPTQLYISLSASRSERYHEICKPQSKKYWKKLLETLNLLKSF
NCPSAIRLTLVKGLNLEDPQGYAKLISKADPTYIEPKAYMYIGYSRRRLTFENMPTYKQV
REFSLKLAESTGYRIIDDSVQSRVALLSKLEKPIKVC
>A0A7C4FCR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVEAYRRQRYHFIGRLAVLKPCHWTRKSILTGGREVCYKQRFYGIQSHRCIQMSPTIACN
LRCVFCWRVQPGDLGLGWDEVNVLAYDDPEDIVEKGIFEQRRVLSGFKGNPKANMKMVEE
AFNPRHAAISLVGEPTLYPMLGELIEAFRRRGFTTFIVSNGTNPKALLNLSSEPTQLYVT
LAAPTREVYLKAMRPLIPDAWERLNETLEVLRSFKCPKVLRLTLAKNVNMLNPDGYAKLI
LKAEPTYVEPKAAMSIGYFTKRLTVDSMPKHDEIKTFAIELSSLTGYKLVDESPQSRVVL
LSKLNKPIKLT
>A0A2E8EF16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MYADTDVDLSAPLELKKLYQHQGYRLVGNHSAVKICHWAKKSLRTGGREHCYKQRFYGVP
SHRCLQMTPSLGRCTQSCLFCWRATPETIGAIWDQSRFPAAESGDPETIVEGCLAAHRKA
ISGFGGNPKVTSEMWRQANEPYHAAISLEGEPTLYPRLGELIEAFYDNGFKSVFIVTNGL
DPNAISKLSTEPTQLYVSVCAPDEETYNRTCRPLISDGWKRLNETLELLRSFSCPTVIRH
TLIPKLNMHNPVGYAKIAKVSYPTYIETKAAMSVGYARKRFGYNEMAWHKDIRSFAKKLS
KESGYNIIDEQPLSSIVLLSRLENAIQFF
>A0A022RYS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erythranthe guttata|TrEMBL
MPLPTPPSRLTIFTLLSATATIYFLYKSRHRQRKLLTRLRQVLTKPQSGNPNPATPPKRG
KLFFLSETNTSKRLAQRLHELLTLNGLSFDLVDPKDYEPEDLCRETLVLIVASTWENGGA
PGNGAFLVNWLAESAEDFRVGALVLKECRYAVFGVGSRSYGETYNAVARGVSVKLRKLGA
GELVELGEGDVDEGDLDEIFDQWSKKVVGVLNGNLGENEGPSDNCEVASESEGEEGEYSE
EDDEDEEVEENGVVDLEDIAGKGPSRKSGAVVKANGKVNGQVSNGVKEMVTPVIRANLEK
QGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGKNWQWKMDDPLVIVDTAIDLHTKMIKQMKGVPGVKAELLAEGLSPRHCALSLVG
EPIMYPEINSLVDELHKRRISTFLVTNAQFPDKIKLLRPITQLYVSVDAATKDSLKAIDR
PLFGDFWERFVDSLKALKDKQQRTVYRLTLVKGWNTEDLDAYSSLFDVGVPDFIEIKGVT
YCGSSATSKLTMENVPWHADVKEFSEALAQKSNGAYEVACEHVHSCCVLLAKVEKFKVDG
EWYTWIDYDKFHDLVEAGEPFTSKDYMARTPSWAVYGAEEGGFDPQQSRFRKERRHPNKT
AN
>C4KGZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A101F2Y6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archeaon 56_1174|TrEMBL
MSDEEYWRLLRKHGYQRVGAHSAVKSCLWLKKALRGEGMCYKGRFYGIFSHRCIQMTPTL
MCNQRCMFCWRPVEVEPPAYGWDSPSLIADGAIEAQMRLLTGYGGSSKTDGAALREAHTP
RHVAISLAGEPTLYPYLDELIREFSSRDMTTFVVSNGTCPEVIEKISPTMLYISLDAPDE
HTYRKVCRPIANTWNRVLESLELLPQKRCRTNVRITLVRGLNMHDEAGYATLLEKAQPDF
VEVKAYMHIGFSRNRLARDAMPAHEEVHAFASRIAHFTGYTLVDEVPISRVVLLARDDRT
PRWISGVGHE
>A0A2H3HMX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. radicis-cucumerinum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGRLIKKDDGSTTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQG
YAIVGSHSGVKTCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPELIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEP
IFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPL
HRDFWERFNRCLDILREKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGV
TYCGTSTSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASER
FYVDGKWHTLIDYKKFFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERV
DRKGRKIEA
>A0A554NEF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloglomus irregulare|TrEMBL
MWVPAPLPGMSDSGPRQVDDPDYHSRNHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRC
IQMTPVVNCNERCVFCWRDHQGHSYELDGVEWDDPEAVVEASIELQRQLLSGFGGNDQVP
REAFEEAMEPRHVAISLDGEPTLYPYLPELIKAFHDHGITTFLVSNGTRPEMLADCDPTQ
LYVSVDAADRATFDDVVGATEDDAWDRLVDTLDVLAAKGETRTVLRTTVLQGFNDHHPEW
YAGMYDRADADFVELKAYMHVGHSRGRLDRSAMPDHEEVLAFTGAVQEYLPTHPVLRDVE
DSRVALLARDEDTWVPKLKGGSEFWNGPDEAGVD
>K6VC67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium cynomolgi (strain B)|TrEMBL
MVQGDEAKKRRNFFQTIFEQHAVRKKKKAKINLRIVYGSEGSNSYKKAKGFLNELIQFFQ
DIENICNEVNRIVTEEGGSHHIFNGRTNEVSHGDDKLVSCFLEYSKLLQRRNEQTARSGK
NDSFHAEGVINPSHEALQQFHEKEKKCSDKFVNYLDCCISTNVCTVNFDFVNGNEFNDYT
FFERTSEYDLNVMILFVSTASYGSFPRNCYKFEQLLEDLFNDFRVEKDFLKNIFYTCIGF
GNKQYGSTHFCSPVKKCDKYLAYLGAQKLYKTLKLCDEENNEEAFLMWKCSLFKTISLGL
LFYCFNFPQLCSFMPYADRKIYNSLQHYCFFFCAKADNRKGRDEDIRLRSRTDVASIEVP
QEGGHYSHGVVQKGESPPTNASCSTCGEGTNQGCTPPNGDEWEEVPTSEKNSDDEMVEKS
ALTTYGIKKREDVKSTSLCSSGDELEDLIPDKPKDMLTSNQRNKLTKEGYKIIGSHSAVK
LCRWTKSHLRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNK
DDAEMIVQEALKKHKGMIKELKGAHGVIKERFDEAVHVRHCALSLVGEPIMYPDINKLID
ELHSKNVSTFLVTNAQFPNELQKLHKVTQLYLSIDAPNEEALKNIDRPLFKDFWDRYIRC
IKILKKRKERTVFRFTLVKEYNMMSEEILSYSKLIEYGYPDFIEIKAVTYCGSSDGYQLT
MKNIPWHEEVYQFAFSLIHSNGYLSDAYEIACEHRHSCSILIAKKEFKINDKWHTWIDYE
MFQCLVRQNKDFTAADYCAETPAWAVMGAEERGFNPCDERVYTKGKKKNKPPITE
>A0A1B8FCJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. 03VT05|TrEMBL
MANNEYFGADIASHASENYFMALWHTYRIPLILTLLAVLLITRTVLHLKVGREKIIYTPP
PTPSEKAPVAANPKREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLRDEPANKDVKFQV
LVFYSTLAGSTERTAQTFTTKLADTLKANAESSQYEFLAPIAHDLAELEDYDEYFLGLPK
PEDASQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
VGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQDRLEEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEEAEDDDVEVQSDGAVKLKRKSKKKATSSMDDLEDIGRI
LQKGQNESEEQDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
GAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEG
EEAEVKEETKPTLVEI
>A0A2E3ZG93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPAIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNNRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSDTLNKVNSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDVCHQHGVSTFLVTNGSLPKVIERLDTLPTQLYVSVDAP
NREIFNRLCKPKFDNHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHIEDYARLDKIA
NPMFIEAKGYVYVGNSRNNLSIENMPSHDDIMSFSNTLAPLVGREVLSDRRESRVALIGK
EMIPVTLPEKTRDFPADLGIAKPQNFKLPSF
>A0A2E6HKL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGKFYGIESHNCLQMSPVVD
QCNLACSYCWREPHMDTLELTDQDPLELLYESVRAQRRLLTGYGGNIGVTPEKYQEAQNP
RHVAISLNGEPTLYTKLGEYIELCHKHGMTTMLVTNGTLPKALEKLDTLPTQLYVSVDAP
NKQVFDRICKPKWNSGAWNKFEETIDLLPSLDTRIVCRHTLVKGENMAEEHIAQYAALDN
RADPDFIECKGYVFVGHSREVLSIDNMPSHEDILDFSNKLAPMVGRKVLDDSRPSRVALV
GKEIVPIPIPEREMEFPADLGIAPPVKHLPIIQ
>A0A1X7V140|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amphimedon queenslandica|TrEMBL
MATTPYLFVDVFLDISKEISLSLLFICSIVLLASFYWLYRRPSLPSKVKRTGPLSVRVLY
ASQTGTGKRFAEQLMSEIKLRGFHCSVSDVSHIDPDEEFTTPELSPRSLYVFLISTYSEG
FPPDSARWVFQWLRESVDDCRVSKSLLSGLCFAVFGCGNSLYKDHYNMAAKNLFDWLVQL
SAKSVCQLGLGDANVSQSEHGGLSNDFAAWKNQFLESLERLRNESDENRTKASDHNSKFY
SNQNGNESRQDGSESLRGVSYEEDLDGSSTDDEGVGSEDDVVDVEDIGDMMVKMKKASAD
NKRQNEKKKREMVTPEIRQSLTKQGYRIIGSHSGVKLCRWTKSMLRGRGGCYKHSFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWVWPMDGPERIAQEALANHYQMIKEYRGV
PGVRGERLAEGMKVKHCALSLVGEPIMYPEINKLIGLLHEKKISTFLVTNAQFPDAIRTL
SPVTQLYVSVDASTKESLKKIDRPLFKDYWSRFIDSLKALADKGQRTVYRLTLVKQWNTD
ELEGYAELVSLGQPDFIEIKGVTYCGESKASSLTMANVPWHDEVLTFVKELADLLPDYEM
ACEHEHSNCVLLSHRKFFIDGKWHTWIDYDKFHELNTHYNDTAGSKSFTALDYMAVTPSW
SLIGSAERGFDPGETRWTRKSKRKAESGC
>A0A534LEI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPEKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPAVD
ACNLACQFCWRTQEWGSNSLLAADDPAFIVDESIRAQRELLTGYGGNPNVTRERFLEAWH
PTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHSEGRLPTQLYVT
VAAPNAEIYRKLVAAKSDNEWRKLKETLALLPTLPTRTVVRHTLVEGWNLGWEDEYAELD
RIARPMFIECKGYSFVGESRLRLQAENVPSHASIRTFAGRLADRVGYAIAAEREDSRVVL
LTQDGALHPIPP
>A0A7C5FHM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
METQYEQIYKKQHYSIVGKHSAVKVCHWTKSEFRGGEGCYKGTFYGIKSHQCIQMTPAVS
SCTENCSFCWRFQGFDGMHISDEDDPEFILEESIKAHKKLLTGFKGNPMVSKEKWEESQD
PKHIAISLTGEPTLYSRLGEFIALARKRGISTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKAIFNSVLNPALGNAWENFNRTLDLLPSLDTRKVVRHTLVKDVNFPFLEEYTAMDRRA
EPDFIESKGYVHVGASIANLSQDNMPSHDSIVAFSRELAENLGYVYTAERRESRVALICK
DPSKAKIDFSAI
>A0A2E7WAH3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVKSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNSNAWDKFSETLDLLPSLDTRIVCRHTLMKGINMSKQHIKEFAALDL
RADPDYIENKGYVFVGHSRENLGVENMPSHEDIMEFSNAIAPLTQREVLSDSRPSRVALV
GREITPIPIPQPTMFFPDDLGIAPSVKHLQMANV
>A0A2D9EWC3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKXSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFXQGAFHKLEETLELLPSLDTRTVCRHTLIKHESMGFHEDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEILDFSEKLAPMVGREVLSDRRESRVALIGK
EMIPVKLPIAKKELPKDLGIAKPQRFLLPQA
>A0A7K6CSG4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Origma solitaria|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVTFGISLWIVIQFATTRTKRKESHGSPASSEG
TADKLSNGCAPPPAQEVRVAGVKIFYGSQTGTAKRFAKALAEDVIALNLPVEVFNMGDCD
PEDCLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVEHYNTVGRRVDRWLWMLSANRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCRGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEA
GGTNSVIDVEDLGNIMGHMKKAKVLLLERVPTACLVDQFLQAKLNCLIFASFSGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPELILQEAIENHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPQI
NRFVRLLHQHSISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTEESLRRIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
>A0A7K3YZ78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MPSDPCEPLRKQGYQFFSKTSTAALKPCLWCKRALAGGDMCYKHQFYGIDSHRCVQLTPT
LRCNQRCLFCWRSFEHEPVEAEECPPESILAGIHKYQKKALAGYNAVLDNTVTEERWKEA
LDPKHVAISLSGEPTLYSQLPELIDLFNSKGYTTFVVSNGTNPEMLRRCSPFQMYVSLDA
PDRETYERVCRPLGDYWERVQESLRLLGSRRSAVRITLVKGLNDLALDRYAAILQDSGAR
FVEIKGYMYLGYSQNRLARENMPDHAYVRAFAEKVAAVCDYRLKDENELSRVVVLERIS
>A0A7K7J6B2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Loxia curvirostra|TrEMBL
LEVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRDKRKVTEPGTSDKLG
NGCAPRQAQGIHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVDVINMEDYDPEDGLV
EETSSRNICVFLVATYTEGQPPESAVWFCRWLEEAANDFRVGKNFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTRLQAL
RRGEKKPCRGKCKKGKCKSSGKQSKESSDREHGTSEQDNTEAEELFETSSEEEAGSPDSV
IDVEDLGNIMGHMKKAKVLLLLEGVWNDQAKLNCLMICALFSGYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTKWLWRMDQPEEI
LQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINHLVRLLHQQG
ISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAE
KQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASNLTMANVPWHG
EVLSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYSRFQELVRERERS
GGSRTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKARDTSGS
>A0A5N6WGL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus transmontanensis|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILVRAYGKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKPATANDPAPKVVSGPKRVSGRKPLKVAGRRREDQGPPL
SFIQPIIFYASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
DILIDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAALSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKGLQAATE
>W5M8Z0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lepisosteus oculatus|TrEMBL
ISDLLVFVFCASVCICAYFKLIKDNWKDGWGYFHSCFMSAWQNRFFVYSVAAVCIAIWFT
FQMVMKKENKGVSSTLAQNPKNKKEKGIVAEKVNKVYVSGVKIFYGSQTGTAKGFAEDLS
IDVQSLGLPSEVIDVKDYDPDDSLAEEATSKSVCVFLFATYTDGKPTENALWFCKWLEET
STDFRYGNTYLKGMRYAVFGLGNSVYSSHYNTVCKNVDKWLWMLSASRIMTRGEGDCNVV
KSRHGSIEADFAAWKSRFLTRLQSLAKGEKKSCGKQCKSGRCKNKQKHQQPAEEESESSP
GKEEQSSEEELFETSSEEDFTQDEVATHGPVIDVEDLGQVMNQVKKAKKRGELEEDPGKV
MLSKHSTGRSDDEEAREMITPALRAALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKH
TFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKILKEAVENHQNMI
RQFRGVPGVMADRYEEGMMVKHCALSLVGEPIMYPEINRFLKLLHHHRISSFLVTNAQFP
EEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFQDSLKALGEKQQRTVYRLTLV
KAWNVDELKAYAELVALGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVTHFVQQLADQ
LPDYEIASEHEHSNCLLLAHIKFKVAGEWWTWIDYERFQELVGELEESGGANTFTALDYV
AKTPRWAVFGAKERGFDPADTRFQRKNKTKDLSGC
>A0A5N6ZGW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus coremiiformis|TrEMBL
MTERSMIEGLLTFWHAYRLPILIAVTSVAIVLQAYRKFQPKSKAVTASSVPQSPRSQSPE
KFDQARGEIEKLVVIEKSVSKSAVGNEPAPKVVSGPKRVSGKKPLKAAGRRRESDQGPPL
SFIQPIIFFASLTGTTERYAQVLLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSSLAGYTV
FGFGDKEGWPTEEDGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKNDAESALKEWSRGLQ
DILYDILENGGLGEGVPGSGDPLESDEEDLDDGESNGKRSKRRNDQDVIDLEDIKVSSDG
QTGPLPVDFTTGGKSAPPSQSAEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSA
LRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLIFQ
GVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHDEHIS
SFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKR
HVQRTVFRLTLVKGFNVDDEVVGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVP
FYEEIQEFVVALDKELGRRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFFEL
LEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVYKKGKKKGLHLT
>A0A1L9P523|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus versicolor CBS 583.65|TrEMBL
MADSSAAEGLLTIWHSFRLPFLVAIASVLVILRFRRVLQTRSKAATASSVPPSPRSLTPE
KTPKSDVLPEIVEKKDAGSLSSGRVSPKPTAGPKRVTGKKPTKTAGKRSGSAANEEPQPV
TFIQPIIFWASLTGSTERYAQTVLEDLRTAAQSQANLEDRERGLLPPQIHDLAEVDYDDY
FTTAPKPPSTSPGTRYVYCFLIPSYNIDTILDTFLGHLDETHHDFRIDTGSLSNLAGYTV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTNRKRAYPLGFGDVKSDAESSLKEWISGFQ
DILGDIVKNGGLGEGVPGSGDPLESDEEQSDDEESGSTKPKARGRKKAQAVVDLEDIKMS
ANGQVGSSPVPVDFTTAGAGSQAIQPTEKEMVPKTSPTYTSLTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSP
DLIFDGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLHLLH
SEQISSFLVCNAQHPDQLEALHRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQKCLDI
LREKRFVQRTVFRLTLVKGFNIDDEVVGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLT
MQNVPFYEEIAAFVVSLNDELKRRGLDYGIAAEHAHSCCVLIASTRFKVNDKWHSRIDYP
RFFELLEKEKADGTTFRPEDYMKETEEWALWGNGGFDPNDERVYRKGKKKAIQEATEE
>A0A497I373|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanoarchaeota archaeon|TrEMBL
MEKRVEMLLRKQHYGIVGENGAVKLCAWLKKSLHDKDFCYKQKFYGIQSHRCLQMTPVAN
LCNHNCLFCWRAMDYSRSKVKRFDPPKLIIEGSIWEQRRLLTGFKGDPTANQEKVREAFE
PKHAAISLLGEPTLYPYLKELVEGFHERGMTTFVVTNGTKPEVVRKIKPTQLYVTLPAPD
EKIYVELTRPLIPNGWEKLNETLELMPKIRTRKVIRLTLVKKFNMVKPERYAEFLEIAEP
HFVEAKAYMAVGFSVQRLGYDYMPTHEEILEFSRRIEENSDYKIIDEKKESRVVLLAKKD
YKWRDLNRAQPF
>A0A7J4JH07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon|TrEMBL
MREPEDYMPKAKTALLRNKQYALFGHSAVKVCHWTKKSLTEGKSCYKGKFYGINSHQCVQ
MTPSVGWCQSACTFCWRPLYFDPNGLKEDFLDAPEEIVEQSIQAHFKQLSGFGAQVGTVI
SKEKWAEAHKPRHVAISLSGEPTLYPKIAELISAYRKQGISTFLVTNGLKPEALQFMADT
NQLPTQLYVSFQTPTEQMQKDINRSREKDAWKKLNQTFELFPRLKTRKVVRVTLLKGIND
AENLIQGFADMIGKGKPDFVEVKSYMHIGQSRQRLGRHNMCSHEEIKAWSQKLAKALGYQ
YADDSPESLVALLWNGTTPRFIDFSNQAV
>A0A7J4IUG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon|TrEMBL
MKGQVAVTDKGQAEIASKEIAKLPDYVVKQLHAKKYAVVGNHSAVQVCTYNKKTFKGAEP
CYKEKFYGIDCHRCAQMSPAAMWCNENCVFCWRPMEFMKDVNLDNKIVDEPRDIIDGVIK
SRKKLLSGFGGLPGLHEQKFKEAQLPSHWAVSLSGEPTMYPKICELIVEIKRLPDTKSVF
LVTNAQLPQVFEKMASNEDFLPTQLYVSLDAPNEALFKKINRSVFKDGWERLNKSLEVIG
KLKVRRVIRFTIIRGLNDMPEMAADWAKIIRKANPEFLEIKSYMHIGMSRQRLNRENMLL
HPEVKAFAEKIAEASGYKYSNESVLGRIVLLVRPDLEGKSTKIVFNSA
>A0A7S2VCA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amphiprora paludosa|TrEMBL
MYSSTMDRSGSTWTTVALCAATAAAVWLCTKHHLEQEEEKAKKETNQKNKSLSNASVGGT
TTTTKQTLDTDVSHPPPVTQVNIQDASDNAAAVAEDKDGLFRILRRNSVTIVHGSVTGTC
LKMAKNLQQWSREQFPNRSIQMGSTQEFDWWDELLNDENDNDDDDTNLTKAQAATVPVLL
LLLPTYTDGTWTPPAMSLQDALNELETDWRIAKFPLKGKLQVGILGVGSSAYDDITSANP
TMGRPARQAVRQLQKLGAKCIVRLQVGDSAVGNHDWETYMDWRDRVGNQMGKKVKSQKQV
QIEKSVSLAQATTSTEMTATTKSTTKSTEGDCACQSNTDGDQQHESGCCQTKDADGGEHE
AGCCQSTPEEEANTLNENLIYESDDESEGGEPEVIDLEDMGDAILASQKASAANGEPREM
VTPSQAAALKKEGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMEATPSLA
CANKCVFCWRHHKNPVGKEWKWKTDDPNFIVEQAVNTHVQMIKEARGIPGVRMDRWKEAH
TVRHCALSLVGEPIMYPRIDELLADLHRRKISSFLVTNGQHPPAIESLRPITQLYVSVDA
PTKESLIEIDRPLFQDAWERLRQSLTSLKAKGQRTVARLTVVKGWNSDEITGYAELIALG
HVSLVEVKGVTFCGKSDASNLNMSNTPYHHEVVALTTQLKIELDKLREKQSSDEEPIPEY
GLACEHKHSVSVLLAPVDQISEE
>W7A5G4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium inui San Antonio 1|TrEMBL
MVQGDEGKKRRNFFQTIFEQHAVRKTKKAKINLRIVYGSEGSKSYKKAKGFLNELIQFFK
DIENICNEVNRIVTEGGSHHLFNGRTNELSGHRDDRLVGCFKEYLKLLQRRNEQNARSGK
KDSFYAEEVNAAHEALQEFQDKEKKCSDKFVNYLDCCISNNVSTIDFDFVNGNEFNDYTF
FERTSEYDLNVLLLFVSTASYGSFPKNCYKFEQLLEDLFHDFRVEKDFLKNIFYTCIGFG
NKQYGSSHFCAPVKKCDKYLSYLGAQKLFKTLKLCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQVYSFLPYEDRKIYNSLQHYCFFFCAKEDNRKRRDEDIKVRSRSDETSIDVPQ
EGGQNSHRAVQKEENSESGHPPKGDPFKGDHSTNASCSTCGEGTHHGCTPPNGDEWKEVP
TFEKSSQDEMVEESALTTYGMGKREDVKRSTSLCSSGDELEDLIPDKPKDMLTSNQRNNL
TKEGYKIIGSHSAVKLCRWTKSHLRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCW
RHHKNAVGTHWKWNKDDAEMIVQEAFKKHKGMIKELKGAHGVIKERFDEAFHVRHCALSL
VGEPIMYPDINKLIDELHSKNVSTFLVTNAQFPNELKKLHKVTQLYLSIDAPNEEALKNI
DRPLFKDFWDRYIRCIKILKKRKERTVFRFTLVKEYNMMSEEILSYAKLIEYGYPDFIEI
KAVTYCGSSDGYQLTMKNIPWHEEVYQFAYSLIRSNGYLSDSYEIACEHRHSCSILIAKK
EFKINDKWHTWIDYEMFQSLVRQNKDFSAADYCAETPTWAVMGAEERGFNPCDERVYTKG
KKKNKPPFTERTSQ
>A0A8C0GY74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chelonoidis abingdonii|TrEMBL
LDASVDTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWICFQFLAIKAKKQGFATILAEAIL
SRNLPAEIINMRDYDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCKWLEEAVNDF
RFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRIMTRAEGDCSVAKSEH
GSIEADFDAWKGRFLARLQALRKGKKKPCSGNCKKGKCKSKGKQSKEGSDHEQRVSEQEN
TEVEDLFETTSEEESGAEEDRSRNSVIDVEDLGKIIGHMKKAKKECELEEEAGKTGPSQQ
SSGKNEESERREMITPGLRDALTKQGEGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILREAIENHQNLIKQFKGVPGVRVDRFEEGMVVKHCAL
SLVGEPIMYPEINTFLKLLHRHNISSFLVTNAQFPVEIRNLEPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEV
KGVTYCGESSASNLTMANVPWHEEVVHFVRELADLIPDYDIACEHEHSNCLLIAHKKFKI
DGEWCTWIDYDRFQELVQEYENSRGSKTFAAADYVAKTPHWAVFGSRERGFDPLDTRFQR
KNKTKDISGC
>T0M1U1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ferroplasma sp. Type II|TrEMBL
MLPEHVVFSRFRLQRVYICILNLFLMINNYEAVYKKQHYGLVGSHSAVKVCHWTKSELLG
KAPCYKNTFYGIKSHQCIQMTPALNQCSENCDFCWRFQGFDSMHINEEDDPEFILEESIK
AHLKLISGFKGNPKVKKELFEEASHPRHMAISLTGEPTLYTRLGELIEAATRRGITTFVV
TNGTMPKVLETLNPLPTQLYVTVAGPTKEIFNDVLHPAIGNAWENFNKTLDLLPSLDTRT
VIRHTMVKNVNFPFYDEYEKMDRRADPDFIESKGYVHVGQSAGRLSYENMPTHDEIMEFS
STMAKRLGYFEYADRFESRVAMIAKNPETARINVDAEIQKTLKKLELSSD
>A0A7K5KR37|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vireo altiloquus|TrEMBL
LDVSMDTWSYFHTCLLSIWLHRFYIYSAVAFGISLWIVIQFATARTKRKVTEPSLGVPPS
SEGTADKLGNGCAPPQAQEVHVAGVKVFYGSQTGTAKRFAKALAEAVNSLNLPVEVINMG
DYDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRY
AVFGLGNSAYADHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKG
KFLTRLQALCRGEKKPCSGKCKKGSCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSE
EEAGGTDSVIDVEDLGNIMGHMKKAKVLLGEGVWNAHGVDHSGYQLVCFVCQFLQAKLNC
LMHFALFAGYKLTGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKG
>A0A2K0SZM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma gamsii|TrEMBL
MDAGNRFQLGTAVADLVELWHAYRTSIILCALVLLVGLRTLLHTAEEREPLAVLPKIYNQ
EKPETSEETAREAQPVAAAEKKSTGPRRIKGGVTRKPSQENKATAVDTDKPTKILVFFSS
ITTKTEKIAHEYIKTLETFLDQKAGETESKFLKPELLDLTEIDFEDYFVSPPKSAENAAY
VYLFLLPSYNIDSINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEGF
CFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHTERFTEWTTGVQDVVSQAVQTGFLGEGV
PGSGDAVESDEEDAEADDGEVVFDDEESGDGKSSDDSRPLDDVEDLGKMIRPNKDGNGTT
RKAPLAVDFTTYPSATKKKAQAPIIKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEAEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLQEKGLDYGIAAEHAHSCCVLLASKRFNVNGKWHTHIDYQRFF
ELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVTREAPE
>A0A8B9EQG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anser cygnoid|TrEMBL
MPAKAGCKRPAACLVLLRQLCVAHEPCAAALRKCFLPFLGTEPALDLDVSMDMWNFSYTC
LASLWLHRFYIYSVIALGISLWIVVQLFTTKKKGEKSNGNLFSEVVEEKQANGYAALQAK
EVYVAGIKIFYGSQTGTAKRFAKGLAEAVTSLNLPVEVISLGDYDPDDCLAEETTSRNIC
VFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVG
RNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLNCLQALCRGERKPCS
GKCKKGKCKSQGKQSKESSDHEHGASEYENAEAEELVETSSEEEADAEEVGGTNSVIDVE
DLGNVMSHMKKAKRERELEEGVVGTSLSGETAGRKEAGEKREMITAALRDALTKQGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYP
EINRFLKLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDF
WQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKPDFIEVKGVTYCGESS
ASSLTMANVPWHEEVVRFVQELAELIPDYEIACEHEHSNCLLIAHKKFKVDGEWCTWINY
ERFQELVREHERSGGSKTFTAADYTARTPRWALFGSSQRGFDPLDVRYQRKNKAKDISGC
>A0A8J5UMP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. raphani|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
PTTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A6RH86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces capsulatus (strain NAm1 / WU24)|TrEMBL
MAGDDLQIFAQRLLTSWHRYRIPIFFLAAVVSIVIWLSTRSHKRNTPLSDSLSPCQSEKQ
NQNDKAESCRVELSSKNDPAAAFFPNSDHSGSSIESQVRQAKQSANGPKRVHGSKPVKRG
ANNRTNPGELSRDINIQPMVFYVSLTGSTEAYAKSFCHRLQKATHALIENHSKTAILTPQ
LHDLSYIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRID
TSSLSALAGYSVFGFGDREGWPSEEEGFCSQARDVDRWMAKLTGKKRAYPLGMADVKGGN
TQTVLNDWCDGLSGIMFDLISSGGLGEGFPGSGDPIESDEEDIHDSEENDENGRSFRNKR
KEEQIVDLEDIKFGVTDGKGTSADRQLLPIDFTTQSHPQASKPVSQPQLEMVPTSSPTFT
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWKVDPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCF
VEVKGVTFCGTSTSASAGITMQNVPFYEEVVAFVVALNAELTRRGLGYGIAAEHKHSCCV
LLASNRFYVNDRWHTRIDYDKFFTLLEKEKNNGISFRPEDYMRETDEWALWGNGGFDPND
TRVYTRGKNKAKLNAVLKASEQNATSVEG
>A0A8D6PWE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus sp. SG7|TrEMBL
MIPEEIYKILRKQRYQIYNHIGVKLCGWVRKKMLEDKNCYKSQFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPTDINIDINKIKEPKWEEPEVVYEKILELHRRIIMGYGGVIDRVGEK
KFKEALEPKHVAISLSGEPTLYPYLDELIKIFHKKGFTTFVVSNGILTEVIEKIEPTQLY
ISLDAYDLESYKRICRGKEEYWESILNTLDILKEKKRTCIRTTLVRGYNDDILKFVDLYE
RANVHFIELKSYMHVGYSQKRLSKENMLQHDEILKLAKILEENSSYKLIDDNEDSRVALL
QNENRKINPKIFE
>A0A3M9ZGT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon S14|TrEMBL
MSCSGEVAEPEGIVQIEGLKAARLRRAKYGISDHGTVGLCHWTKRSFRGRGTCYKHSFYG
ISTHRCMEFSPAGMHCQNRCVYCWRPVEFYDSMAIEAPRAADPEEMMRGLMAERRRLLMG
HYGDAAADSALIDEAQLPSHYAISLSGEPTMYPHLPELIRHLKSLEATKSVFLVTNGQEP
SMIRRLRDEDALPTQLYLSANAADRESFMRINRPRYADSWERWNETLGLLDGIGTRTVIR
VTLIRGHNADAKGHGAFARMLESSGAHFVEAKSYMHVGRSTERLERESMLEMDEVREFAR
GIEVRGPFEFMDESEVSRIVVMRNSRRPIERMIAAYA
>A0A5F9D9H3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryctolagus cuniculus|TrEMBL
MDPPLDVWGLSSSLLSLWINRFYIYWGFAFGISLWICVQIVIKRQAKNSQVKSVSKANQE
LMTNGYISLQKREIFVSGVKIFYGSQTGTAKGFAASLAEAVTSLDLPVEAINLKEYDPDD
HLAEEVTSRTVCAFLLATYTDGRPPESAEWFCKWLEEAASDFRFDKTYLKGMRYAVFGLG
NSAYSNHFNKVGKNVDRWLWKLGAHRVLTRGEGDCNVAKSKHGSIEADFRAWKAKFISRL
RALCKGEKKSCGGNCKKGKCESKQHGPEEVEPGPHTQDEAHHRGPKEEEPCESTSEEECG
PEDHQGFSSVVDVEDLGKLMDRGKKEKREKEQQEEKTSLFRSTGKNEDDGRRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWQWKMDPPEMILKEAIENHQNMIKQFRGVPGVKAERFEEGMVVKHCA
LSLVGEPIMYPEINSFLKLLHQCKISSFLVTNAQFPTEIRNLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALATKQQRTVYRLTLVKAWNLDELQAYAELVSLGNPDFIE
VKGVTYCGASSASSLTMANVPWHEEVVRFVRELVELIPDYDIACEHEHSNCLLIAHKRVI
IPQ
>G1SJ63|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryctolagus cuniculus|TrEMBL
MDPPLDVWGLSSSLLSLWINRFYIYWGFAFGISLWICVQIVIKRQAKNSQVKSVSKANQE
LMTNGYISLQKREIFVSGVKIFYGSQTGTAKGFAASLAEAVTSLDLPVEAINLKEYDPDD
HLAEEVTSRTVCAFLLATYTDGRPPESAEWFCKWLEEAASDFRFDKTYLKGMRYAVFGLG
NSAYSNHFNKVGKNVDRWLWKLGAHRVLTRGEGDCNVAKSKHGSIEADFRAWKAKFISRL
RALCKGEKKSCGGNCKKGKCESKQHGPEEVEPGPHTQDEAHHRGPKEEEPCESTSEEECG
PEDHQGFSSVVDVEDLGKLMDRGKKEKREKEQQEEKTSLFRSTGKNEDDGRRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWQWKMDPPEMILKEAIENHQNMIKQFRGVPGVKAERFEEGMVVKHCA
LSLVGEPIMYPEINSFLKLLHQCKISSFLVTNAQFPTEIRNLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALATKQQRTVYRLTLVKAWNLDELQAYAELVSLGNPDFIE
VKGVTYCGASSASSLTMANVPWHEEVVRFVRELVELIPDYDIACEHEHSNCLLIAHKRFK
VDGEWWTWIDYGRFQELIQVYEDSGGSETFSAQDYMAKTPQWALFGASERGFDPKDTRYQ
RKNKPKAISGC
>D7DC54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Staphylothermus hellenicus (strain DSM 12710 / JCM 10830 / BK20S6-10-b1 / P8)|TrEMBL
MQRSIDWGEVRRKREEFWNSSPVYKAIYERMKKQGYHFIGTIGVVKRCHWTREALVNRRF
CYKCLWYGIESHRCVQMSPVAAWCWLRCLHCWRIQPEDIGMHWDETRIPVVDDPEIIAEE
SIRVHRQIVAGFKGNPKVDPRMVEEAMNPKHVAISLTGEPTLYPRLGELIREYHRRGMTT
FLVTHGVRPDILAGLEEEPSQLYLSLEAWNKQKFMEFNRPIVPRAWELIMETIDLFPSFK
CPTVYRITLVKGFNDSDEALEGFAKLIERGNPTYVEVKAYMFIGYSRGRLTSANMPSHEY
VREIAKKLADLTGYMVLSESIPSRIVLLSRIKEPIRHGKGCPDGVKHPEKYAWVITHEYE
EMKS
>A0A3M0WFP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chaetothyriales sp. CBS 134920|TrEMBL
MDSAENSEWLIHTADWIDRFLTFWHDHRLLAFAVVVCLSLTTHVLVRRREEVDGVAVPSP
PCSAVEKGVVDAVPDDKRVAPARTIPAQTASKARPVKVVTGRRPDKKLTARSSSSPTDLK
LRPFVFYVSLTGTSERLAKHVAAQLRRLGSASSSSSRVLEPELLDLSYIDLDDYFISGPK
APGSSDNEPTAWPFYAIVIPSYDIDTILNNFLAHLDETHNDFRIDTSPLSTIAGYSVFGV
GDQEGWPSEQQAFCYQAIEVDKWLAKLTGRKRAYPLGMGNTKGDLDKSLDEWINGLSDAI
NDIVATGTLGEGVPGSGNAVESEDEEEAEEAEFPDGGRRKRQKTSLSTDLEDVGGAKKVT
AKGGAPLATDWTGAYSSRTATASASAPAPAAPLKAMVPKESPTYTALTKQGYTIVGSHSG
VKICRWTKSALRGRGSCYKNSFYGIASHLCMETTPALSCSNKCVFCWRHGTNPVSTTWRW
QVDDPRLIFEGAKEGHYKKIKMMRGVPGVRSERFQDAMRIRHCALSLVGEPIFYPRINEF
VSLLHGERISSFLVCNAQHPQQLESLQRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFN
TCLDIVREKRFVQRTVFRLTLVKGFNVEDEAEGYADLVAKALPCFIEVKGVTYCGTSTAT
GAGLTMQNVPFYDEVVQFVQALNDALDRRGLGYGIAAEHAHSCCILLASNRFHIGGRWHT
VIDYDRFFALLEAGQDFGPEDYCKATPEWALWGKGGFDPRDERVDRKGRKKE
>A0A449BX01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vinckei vinckei|TrEMBL
MVTKREDELVPPPNEGGNINFYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIIFFND
ILNHFNTISIITKGDKKNDTIFDGSINNEINNIEDYMLEYFRSKLLKTNKKNKDRKYGKN
CKNEKENITNNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCFIENNISEIHFD
FVNGNEFDSYTFFENSENNDLNILFMFISTYNFGSFPANCYKLEDTLTDLVNDFRVEKNY
LKNIFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLKLCSTMDNEEEFVNWK
SSLLKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSEDAKSMPINDGE
NKQTTKSVDNSNINKCDCINNGMPSEHLNTSKESVNGHISFSTSQNDGNITERCGCISNN
CLNGNDKYINDKKIINNNFETSIPNGCCKNEYEQDDKLVNSDFSNESINENNDEINCNSS
EDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQIRGRGGCYKHTFYG
INSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKELK
GVHNIINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNELK
KLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKEKKERTVFRFTLVKEYN
MMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSKR
SISDIYEISCEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVKQNVNFSAIDYCAETP
EWAVVGAPECGFNPSDQRVYTKGKNKKKNNINTMEVKT
>A0A7L4RFC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MPYIPEVLASQLRKQQYHIVGSHSAVKSCKYLKEGILGKRLCYKHTFYGIDSWRCLQCST
MVSCNLSCRFCWRISPEDVGLSWNEMSTPEWDSPEVLVEGFLKEQKRIVSGYKGNPVVDR
KRWEEANKPAHVAISLVGEVTMYPFLSELIEIFHKMGMSTFIVTNGTLPDKLSSMKDLPT
QLYMSLEAPDEETYLKTCRPKVKGAWENVNRTLELFPSLKTRKVLRLTLVKRLNMHKPEG
YAKLILRAEPDYVEPKSFVFVGGARYNRGLELGDMPSHGEIREFAERLSKETGYIISDER
TDSRVVLLCRDKDAERKRMLQKK
>A0A497FHT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MKSARFTERQIQRYLRAGYRLVGRNTAVEICRWTRSALKGGRLCYKRWYGVNSHRCIQMT
PNLNFCNFACSFCWRIHEEGRFKSTPEWDEPSEIVDGIIRVQRELLIGYKGNPKVPRERF
LEAMFPRHVAISLDGEPTMYPYLSKLITEIKERDMTAFLVTNGSIPARLKELLMENAEPT
NLYISVYGPNKEVFIKTSKPLIPNAWENVLESLDLMDEFDCRTVFRITLVKGLNMVEPEG
YAKLISYANPKFVELKGYTWVGESQKRLPKEAMPRMEEIIDFAAEISRLTGYKIKVMDEK
SRVVMLVKNEEVWNWNLKLVKEQRKIETKADTAWRDKIKDFRLKKIQFEF
>A0A662FVP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MTVSIMAILPKTNVERYLRAGYKLVGIHSAVSICRWTKSALKGERFCYKRWYGVRSHRCI
QMTPVLNFCNFACVFCWRMHLPGRFKLPEGWDWDKPEEIVDGIIVAQRELLIGFKGNPKV
SKERFLEAMFPRHVAISLDGEPTLYPYLAELISEIKNRGMTAFLVTNGSVPYRLRELLKK
DAQPTNLYISVYGPDKEVFEKSANPRIPDAWELVLESLSLMDKFDKSRTVFRITMVKGLN
MVNPEGYAKLVINSNPMFVELKGYTWVGESQKRLPITAMPRLEELRKFAEKIAAISGYQL
KLEDEKSRVIMLVRDEETWQKNLEKIEEWRKKEEELDKSWKGKIKDFRLGREGISILRY
>A0A497GEN3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MSVGRLRPEDVRRYLRAGYRLVGRHSAVEVCRWTKTALKGGHLCYKRWYGVRSHRCVQMT
PVLNFCNFACVFCWRPHLSGRFRIPPGWEWDEPSEIIEGAIRAQRELLIGFKGNPKVTRE
RFLEAMFPRHMAISLDGEPTLYPKLAELIKGVKARGMTAFLVTNGSVPHRLEELIRKGAE
PTNLYISVYGPNPEVFEKAARPLIPGAWELVLESLDLIPRFSCRTIIRLTMVRGLNMVEP
EGYAKLIERAQPRFVELKGYTWVGESQKRLPREAMPTLEEIEKFARKLEELTGYRIKVSD
EKSRVVMLVRDEETWEWNLKLLEEWRELEKKLDSEWKGRVRDFRLKNQPNKF
>L9WVI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronococcus amylolyticus DSM 10524|TrEMBL
MSDSADPATGSGTPEADDGGADDTPAQISSPNYHSENHTAAQTCGWTANALRGEGRCYKN
VFYGIQSHRCIQMTPVVKCNERCVFCWRDHRGHAYELGDVEWDDPEAVVDASIRLQKKLL
SGFGGNDDVPREVFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTRP
EVLRECDPTQLYVSVDAAERHTFDQVVKAVEDDAWDRLLETMDVLREKDETRTVLRTTLV
KGENMHHPDWYAGFYQQADPDFLELKAYMHVGHSQGRLDRSSMPDHEEVVDFTEQVQEYM
PEFTELRGVPPSRVALLAKDEETWVPKLEQGSEFWERDPVTGD
>A0A427UCG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
EKFIASKLPV
>A0A0D5ZGC3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MENNYVQIYKKQHYGLVGKHSGVKVCHWTKDKLRGGEGCYKGTFYGIGSHQCVQMTPALT
SCTENCSFCWRFQGFDSMHISDEDDPEFILEESIKAHRKLISGFKGNQNMSKEMWDEAYN
PKHIAISLTGEPTLYTRLGEFIELARKRGMSTFLVTNGTLPMVLEKLDPLPTQLYVTTAG
PNKEIFNELLNPAIGNAWENFWKTLELLPSLDTRTVIRHTLVKDINMPYLDEYTKMDSVS
QPDFIESKGYVHVGQSIYRLSIDNMPSHDSVVDFSKQLASNLGYDFTAERRDSRVTLISK
DPSKAKIDFSQIVPEGIN
>A0A8D0GAY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphenodon punctatus|TrEMBL
LDVPLDTWNYFYAHLMSLWLNRFYIYSCAAFGISVWLCIQFITKTKKQGEKYSGKITPPK
VTEDGLANGYKSLEPNVVHVSGVKIFYGSQTGTAKRFAGILAEAVVSLNLSVEVINMRDY
DPDDCLVEETTSKNICVFLVATYTDGLPTENAAWFCKWLEEAANDFRFGKTYLEGMRYAV
FGLGNSLYVDHYNTVGKSIDKWLWMLSASRIMTRAEGDCNVAKSKHSSIEADFGAWKVKF
LSRLQALSKGEKKSCSGNCKRGKCKSQGNLSKEGSDHEERASEQEEEELFETTSEEESGS
EEDINSVIDVEDLGKVMGHMKKAKVLHTKILETSIVSSPKSSRCLNFLSSYPGYRLIGTH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEW
RWKMDQPEMILQEAIENHQNMIKQFKGVPGVRADRFEEGMMVKHCALSLVGEPIMYPEIN
RFLKLLHSRNISSFLVTNAQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQR
FLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSASN
LTMANVPWHEEVVHFVQELAAFLPDYAVACEHEHSNCLLIAHKKFKIDGEWWTWIDYDHF
QELVQDYEKSGGSKTFTVADYVARTPHWAMFGAREKGFDPMDTRFHRKNKAKDISGC
>A0A5E4KUK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MKASITESTKEILNKHGYHLAGTHGAVKTCLWLNKSMRNDGACYKSLFYGMSSHRCIQMT
PTLACNHRCLHCWRAVELETGIPQVWDPPGTIVDSCLIEHRRLVSGFGGSETMDKTKWKE
AFAPRHVAISLAGEPTLYPYLPELIDEFHKKGMTTFVVTNGTNPEMIPKIKPTQLYMSLN
APDKETYEKACAPIGDTWENIRTSLGLLKNSKTRTAVRMTLTRGVNMKASEGYSDLIRIA
EPDYVELKAYMHLGFSRKRLSRECMPLYGEVLDFSKKIAKSLDYSIADTSEASRVVLLSK
DGTKSNIV
>A0A229XRD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neosartorya fumigata|TrEMBL
MAEHSTAEGLLVFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSRESSNKATAQKAEQQPALANGSAKPTSGPKRVTGKKPSKVAGRRGQTEDAEPL
NFIQPIIFYASLTGNTERYAKVLLDELRVAAQKRADLRDRERGLLPPQIYDLSYVDLDDY
FTSAPKPPPTSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAETSLKEWSLGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDLLHGEHISSFLVC
NAQHPDQLHALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLNILREKRHVQRT
VFRLTLVKGFNIDDEVIGYADLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEREK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A7L4PNM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosa archaeon|TrEMBL
MEKVWSILKRQKYRIVGAHSAVKICHWTKKSLTEGRVCYKQRFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDIPTKYDDPEAIIEGCIEAQRELLSGYHGFLEKVDINKLKEAEN
PTNVAISLAGEPTLYPDLSGLIEGFRKRNFSTFLVTNGTTPEVLSSMDTYPDNLYITLPA
ASKDTYEHVCNPQIKEGWEKLNESLELLPKIKTKRRILRLTLVKDFNMSDVDKYSKLIEK
ANPDFIEAKAYMYVGYSRKRLEIENMPTFEDILEFCKKLEEESGYKAIDSASDSRVVLLS
RD
>A0A1J3K4W2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Noccaea caerulescens|TrEMBL
MAASSSLRARLAFVVLLSATTFYCIHKYRRLKRLKNLSLNPSTPTSKASRGKIFFISQTG
TAKDLAQRLHELCAANDIAFDLVDPRSYEPEDLSKESLVIFIASTWDGGKPPQNGEFLVN
WLSESAEDFRVGSLLLSECKFAVFGVGSRAYGESYNAVAKELSSRMVGLGGLEMIPVGEG
DVDDGEVDSAFQEWCAGVIRALKGGSEQESNVVLQNGAVENDDEYIDTTDDEDDNNAEAD
IVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEI
VKGALDLHTKMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGKR
ISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQE
KQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHA
DVKAFSEALSLKSEGEYEVACEHAHSCCVLLGRTQKFKKNGKWFTWIDYEKFHDLVASGE
LFTSTDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQAVLA
>D5VQT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus infernus (strain DSM 11812 / JCM 15783 / ME)|TrEMBL
MIFEILRKQRYQIYKHVGVKLCGWLKKKMLYNKDCYKSKFYGIETHRCVQCTPSVIWCQQ
SCIFCWRVLPRDLDIDEFPSPEWEKPEVVAEKILELHKKAIMGYKGILDRVGEKKFEEAL
NPKHIALSLSGEPTLYPYIDELIEIFKDKGFTTFLVSNGILTEVIKKIKPTQLYISLDAY
DLESYKKICRGKEEFWEHILETLNILDKKERSCIRTTLVRNYNTNIEKFIPLYELANVDF
IELKSYMHVGYSQRRLKKEHMLSYDEILKLAKKVEENSRYKIADGCEESRVVLLVNKDKD
VSVKI
>A0A8D0FKG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strix occidentalis caurina|TrEMBL
MGLGLGDAGTENQLVQVSEVLLHELGGSWVQLDPVISLVWGMSVFAKSLAEAVVSLNLPV
EVISMGDCDPDDCLSEEVGTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGNM
YLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEA
DFEAWKAKFLSRLQMLCRGERKPCSGKCKKGKCKSPEKQSKESSEREQRASEYENTEAEE
LFETSSEEEADAEEAGGTNSVVDVEDLGNIMSHMKKAKVLLLERFGCSCCVLTFLVFVCV
SLLLVDASRPRRLHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIE
NHQNMIKQFKGVSGVKAARFEEAMTAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLV
TNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTV
YRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANIPWHEEVVLFV
QELADLIPDYEIACEHEHSNCLLIAHKKFKINGEWCTWINYDRFQELVQEHERSGGSKTF
TAADYTARTPHWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A151EN52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon SG8-5|TrEMBL
MDERLSRILEKQHYHIVGSHSGVKLCHWLGEKLLRGRSCYKETFYGIRSHRCLQMSPAVN
NCTQSCLFCWRYQGLSETGLDVEDDPESILEGAIEGQRRLVTGYKGDPRTTPEMWAEASE
PNMVAISLAGEPTLYGQLGGFIDACNKRGMTTFLVTNGTEPEALERLDPLPTQLYVTLAA
PNEEVYRRLCVPLVKDGWQRLIRTLELLPDLNTRTVIRHTLVDGWNIGWEKEYARLIETA
DPMFVEPKGYVFVGYSRERMRNSNMPAQETVRAFSDNLAKETGYEVLAEQGSSRVVLLGK
DKRAMRIGDD
>A0A2G2ZS81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capsicum annuum|TrEMBL
MPLSLSSYPTRLTILTLLSATTLYFFYKSRRRLKSLNPNNPQTPKGKIFYISQTGTSKTL
AKNLHICLKLNGFEFDLVDPKEYEPEDLCKESFVLVVASTWDDGKSPENGGFFVDWLNES
VDDFRVGGLLLSECKFGVFGVGSGSYGDKFNVVARDFSRKLRKLGGVEVLELCEGDVDEG
NLDEVFGEWSERVVGVLRGENGGGGYMGNDEVGDVRDEEEYNDDDDDELEENDEGSGIVD
LEDIAGKGPSRKKGVGDNKLVNGKLNGGVVNGEKAMVTPVIRASLEKQGYKIIGTHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWTWKM
DDPIEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEINSLVD
ELHKRRISTFLVTNAQFPDKIRLLKPITQLYVSVDAGTKDSLKAVDRPLFGDFWERFLDS
LKALKEKEQRTVYRLTLVKGWNTEEVDAYSSLFSIGKPDFVEIKGVTYCGSSATSKLTME
NVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKMNGQWFTWIDYEKFHD
LVASGKPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRYKKERHHKSSRKENGSLKE
>A0A218ZJW4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon ARMAN|TrEMBL
MPEQLQKRMEKQGYHFVGQHSAVKICEYTANGLRGETLCYKYTFYGIRSWQCIQGTPAIG
CDIGCRFCWRLIPEEEGFKWNELNALSEWDDPEGIVEGMIKEQRRIVSGYKSIADNELKM
RRWNEANEPKHVAISLTGEPTFYPKLAGLLSAFHKKGISTFLVSNGTLPEAIAKLDPLPT
QLYISLQAPDEETYIYVTRPKIKDTWNRFMKSLDMLHTLKTRTVLRMTLIKGLNMKNEEG
YAGLIKRAMPNYVEVKGFSYVGGARNEERGLSLSSMPNHSEIRDFADRLAELTGYKRVSE
HAPSRVVLLARDEESARNRIIDFSKIG
>A0A847V1G7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MAEMLKRQGYHLVAHGAVKPCLWLRRSIRGGDQCYKHHFYGIASHRCVQMTPTLLCNHRC
LHCWRPIDEIPTASGDWIEPPELLDGILSEQQRLISGYGGAPETTDLARLEEARRPAHVA
ISLMGEPTLYPMIGELVDEVKRRGMTAFLVTNGTIPEVVGEVRPTQLYISLNAPDEETYL
RVSNPRDDYWGRFLESLATMRDSPSRTVARLTLARNLNLKDPQGYAKLIEIAEPDFVEVK
AYMHLGLSRKRLERDSMPTHDEVMSFAGELSDILGYTLKNHVPLSRVALLSRGSSPEKIE
L
>A0A842ULW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MARLSEKHKQALENAHYEIVGRHSAVEICSWCKKSLLDEGVCYKQKFYGINCHRCCQMTP
SAGWCDQNCVFCWRAQELNEGIRMDADVDAPKKIVDGCIKAQIRKLSGFKGNEKTNMEKW
KQAQEPMHFAISLTGEPTLYPKLPKLIKEIHKREKTSFLVTNGQHPEMLLRLKHENALPT
QLYISVDAPTRELHTKIDKSTNKNAWERLNKTLEILPELNCRKVIRITLIKDMNDCCVSE
YAQLLEKAGDDVMVEVKAYMFIGYSRKRMEKENMPTHEEVMEFSKKLAQELGWNVIDEGV
RSRVVLLAKKDFKSRIMKFN
>A0A6J1HDZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cucurbita moschata|TrEMBL
MSLSSRSAKLALLALLSASTLYCFYKSRRLRKLKLSLNPTGCSRRPKLFFISQTGTSKAL
AHRLLNVLNSNELAFDIVDPKDFEPEDLFKETLVLFVASTWEDGGPPPHAKFLASWLSES
AEDFRVGSLLLSQCKFAVFGVGSRAYGETFNAVARDFSKRMKALGAKEILAVGEGDVDGG
DIDKCFDDWSRQLLKVLKVDAVGTGADLYSGIDEDFDAESVEEDDEDADPGEEDIVDLED
IAGKGPSRKSTNVVETNGKLNGKKVMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPLDIVNSA
IDLHKKMIKQMKGVPGVTQEKLEEGLSPRHCALSLVGEPIMYPEINTLVDELHRRRISTF
LVTNAQFPDKIKSLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALNDKQQR
TVYRLTLVKGWNTEDIDAYSNLFSLGKPDFVEIKGVTYCGSSNTSKLTMENVPWHSDVKS
FSEALAAKSQGEYEVACEHVHSCCVLLAKTDKFRIDGQWFTWIDYEKFHALVASGKPFDS
KDYMAPTPSWAVYGADEGGFDPVQSRYRKERHHRPKPTS
>A0A2E9U4M1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MAIALNVSDEQKELKDKRRYSEGYRLVGNHSAVKVCGYCRKALTGKDVCYKNTFYGIESW
RCIQMSPTFFCGHKCVFCWRDIDYVWPKWQGPVDDPKFIVDECIKAHIELLQGFKGNSNV
VVERLKKMEKPLHFAISLTGEPTMYPNLAEMIDYIKEKGMTAFLVTNGSIPDMVEELVEH
QPTQLYISVYGPNKEIYQKTANPINKDAWEKLQKSLSMLHKFDRSVIRLTLVKGFNFVDP
EEYAKLIEKYKPMFVEAKGYSHIGHSQERLEVNNMPYHHEIMEFAKKIEENSSYRVIDDK
KESKVVLLAKEDFDGRKMNFKGI
>A0A7K6CE15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ptilonorhynchus violaceus|TrEMBL
LDVSMDTWSYFHACLVSIWLHRFYIYSAVAFGISLWIVIQFTTTKTKRKKSHGNPASSEG
TADKLVNGCATPQAKEVHVAGVKIFYGSQTGTAKRFAKALAEAVISLNLPVEVINMGDYD
PDDCLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSVYVDHYNTVGRRIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEQGTSEQENTEAEELLETSSEEEA
GDTNSVIDVEDLGNLMGHMKKAQVLLLEGVWNDHCSAHCGFTFKQIYLPVGYKLIGSHSG
VKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRW
KMDPPEMILQEALENHQNMIKQFKGVSGVRAARLEEALTVKHCALSLVGEPIMYPHINRF
VRLLHRHSISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTQESLRRIDRPLFKDFWQRFL
DSLKALAEKQQRTVYRLTLVKAWNVDELQAYADLISLGKPDFIEVK
>A0A423XEE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cytospora leucostoma|TrEMBL
MEFERLGNSPWLARLSDPVVDYWHANRTVLILAAFTILVLLRIYLHLTVGNEPLHVFPKI
YDTEKKIPIVEEKVEVAAPIKSSGPRRIRGELTKRRSTEAQPGRRQIKTLIFYSSLTTNT
EKIAKEFGKTLAGLFESVPTDPACGLSSPEVLDLAEVDFDEYFITPPKLGEQDDVATELF
YLFLLPSYNIDSINDTFIEHLKETHHDFRIDTAPLAPILGYSVFGFGDKEGWPTEEAGYC
VQAKELDKWMAKLTGRKRAYPLGMGDVKRDATQRLSEWTNGLLDVLGQLARDGTLGEGVP
GSGDAVESDDEADVDDDDGEVVFDDESQSKPPKTKSSGSLEDLEDLGRILQNAKTDGAAK
PAPPLAIDFTTSSKRKQPAVQTVKEMVPKGSPTYNSLTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWVVDPPDLIFK
GVTENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHGDRIS
SFLVCNAQHPDQLAALNHVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILREKR
FKQRTVFRLTLVKGFNIEDEAKGYADLVEKALPCFVEVKGVTYCGTSTSSNAGLTMANVP
FYAEVCEFVTALERELVSRGLNYGIAAEHAHSCCILLGSERFNVDGKWRTQIDYDRFFDL
LEEKGPDGDFSPEDYMGPETPEWATWGNGGFDPRDQRVDRKGRPIEI
>A0A8D0DF97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sander lucioperca|TrEMBL
MSIWQNRLYLYSAAALVFGIWFSLKLVLKKKSFSKDVGPWVYKAVKSNDIPDRDTSVHVS
GVKIFYGSQTGTAKGFAEELSEEVKTLGIPAEVIDIKDYDPDDQLADECTNKSVCVFLVA
TYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDK
WLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFVSWKVRFLKRLQALAKGEKKSCSGNCKT
GGLCKSKRKDGQEEEEEKEEEKEEKEDLIESSSDEEDSGLQDEKNSGSVVDMEDLGKIMN
SAKKAKRQTCEEREFKALYPHFCAVREFEKLSNKCCSFSFCAGYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKI
LQDALEKHQSMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHR
ISSFLVTNAQFPKEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGE
KRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQ
EVVAFVQQLADMLPQYEIACEHEHSNCLLMAHTKFKVDGEWWTWIDYERFQELVQAHEES
GGQQGFSALDYMAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A397C0H4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAEPVAVRILYGTHTGTAKGTALSHVVDDNLEHEHVLISILSTWTGGV
PPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLGNSEYDEHYGKASKALSKHLSSLG
ASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGALRSPAASSSSSPSVKPKQQPAGW
KSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIVLELDQGDDSDDEDNRPKKQDSGV
VDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGG
CYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDDAKELVEGAISRH
QTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMYPHINEFCRELHAREISSFLVTN
AQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLTQLKAKGQRTVYR
MTLVKEHNMKELDNYVELIHLGEPDLIEIKAVTYCGKSDASDLTMQNVPYHQEVRDFCEL
LCAKLGGGYELATEHAHSNCVLVAKTKFKIDGHWHTWIDYDKFHTLIQAYYKDGTAFTTM
GYIAPTPAWAVYNAPEAGFDPIETRFQRTKECKVVEIQYTATDSGCG
>A0A0S1XEQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus barophilus|TrEMBL
MTRFVLQKFLNASFYSLLGEPKVENVKPNMPEEIARLFKKQHYALVGRHSAVKLCHWLKE
SIKHNRVCYKQKFYGIHSHRCLQMTPVLAWCTHNCVFCWRPMEGFLGTELPKPWDDPAFI
VEESIKAQRKLLSGFGGIKDRINVKKYEEAQEPKHAAISLSGEPTLYPYIGDLVEEFHKR
GFTTFIVTNGTVPGAIEQMKKEGKLPTQLYVSLTAPDIETYNRVNIPMIPDGWERIIKTL
ELMRDLPTRTVIRLTLVKGENMHNPKGYAELIMKAKPIFVEAKAYMFVGFSRNRLTINNM
PKHEEIEAFAEELVKYLPGYHIEDEYQPSRVVLIMRDDISKEERFIKH
>A0A2H5NSG4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Citrus unshiu|TrEMBL
ISYCRLWGVREMAIARFARLGRHAKRPHGLCVKMTAVAILGLCFIFAWSTFSSSANSVTT
QRESFDDIAEPVSADTKVISSKPQYTERKRQWHEIGKEEDKKVKLESDLDKAKEKKINGS
ASVTVIKHESRKKNEKTVPNVKKQKHTVKSVNEETNEENEKSESDDSLKEDEEEQEQEVV
DGKEEESVSESEVNGETEGDVDLVQQENEQSVVTVEGESGRSRSTGKKRKVKGPVFDPKA
HYSWKLCSTRSKHNYIPCIDNESGFGKFQSYRHTERSCPRSPLMCLVPLPHAGYGSPVSW
PDSKLKILYKNVAHPKLAAYIKKHNWLVESGEYLTFPQNQSEFKGGVLHYLESIEEMVPD
IEWGKNIHVVLEIGSADSSFVASLLDKEVLTLTVGLKDDLVDLAQVALERGFPAVVSPLG
NRRLPFPSGVFDAIHCDGCSITWHAHGGKLLLEMNRILRPSGYFILSTKHDSIEEEEGMA
FIEMGVKIYQKPESNDIYELRRKKNPPLCKENENPDAAWYVPMKTCLHTIPSSIEQHGTE
WPEEWPKRLETYPDWLNDKEKLSSDTRHWKAIVDRSYLTGLGIDWSKIRNVMDMKSIYGG
FAAALAQQKIWVMNVVPVHAPDTLPVIYDRGLVGIYHDWCESFGTYPRSYDLLHADHLFS
RLKSRCRQPVSIVVEMDRILRPGGWAIVRDKVEILDPLEGILRSLHWEIRMTYAQDKEAT
TFYFAYKSRRLNKFLRHSDYRKKPENPNPNKGKLFFISQTGTSKTLAKRLHALLTSNDLL
FDLVDPQTYEPEDLSKEALVLIVASSWEDGKPPEAAKFFMNWIDESANDFRVGSLLLSNC
KFAVFGVGSKSYEKTFNMVAKDLSKKMRELGAGEVLPVVEGDVDGGELDVVFEDWSKRVV
AILKSGGDRLENGIVNGEASIVGVESDPVYHEYDDDEEEEDVVESEMVDLEDIAGKGPSR
RSVNVAETNGKVKDGKRDMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYK
HSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPIEIVNTAIDLHTKM
IKQMKGVPGEYSIFVLLDFFYFGTVSSAIDKQIPPSDGEEKESSVTLERLNEGLTPRHCA
LSLVGEPIMYPEINTLVDELHRRRISTFLVTNAQFPDKIKLLKPVTQLYVSVDAATKDSL
KAIDRPLFGDFWERFLDSLKALRDKQQRTVYRLTLVKGWNTEDIEAYSKLFSIGNPDFVE
IKGVTYCGSSATSKLTMENVPWHADVKAFSEALALRSEGEYEVACEHVHSCCVLLAKTER
FKVNGQWFTWIDYEKFHDLVASGRPFSSKDYMAASPHWAVYGAEEGGFDPDQSRYRKERH
HKSISIAHCNTIKQFSTHGSICVKLKIVLTGEQILRFFISILSMKDVCRVCSVRSDPYPK
>A0A7J7EFR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diceros bicornis minor|TrEMBL
MAAAHRPWVRRTKVDPRRRPEGRLPLAVTTRRRAARQRPQSARPRDSLSPAACHSTLGLT
YCAGARCCERQARKSEQQRLRIVVFTTSFLPKREALVLTQSERDRERSGVLARSSGWCYP
VGPPFPPLSQSERDRERSGALAGGSGRGSPLGPPLPPLSQSGRACERHGCPQLCGVWVYS
QCCQVVLGVSRYPRRPQDPSLDMWDFSPLISLWINRFYIYLGFAFGFSLWICFQIVIRRQ
LGKDSNLMDFVQSFILKDENSQEKSVSKATQDLMTNGDLSLQEKEVFVSGVKIFYGSQTG
TAKHTFFLSGMGFATILAEAVSSLGLPVAIINLKEYDPDDHLVEEGFQLVEFSVSIRGVE
CVVIFRDLSYDKLEMIGIYSLRNGMEYMVTSKNVCAFLVATYTDGRPTESAEWFCKWLEE
ASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRLMTRGEGDCDV
VKSKHGSIEGDFRAWKTKFISRLQALSKGEKKSCGGNCKKGRCKSNQHSSEEMEAESHTQ
DRLHQRDTEEEEPLESTSEEESDTEDHQSLNSVIDVEDLGKIMNHVKKEKREKEQQEEKT
SLFRNTAKNEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKIRDVNTFNSKHSM
LRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILK
EAIENHQSMIKQFKGKVYLYVFVYVYLSKWARVPGVKEERFEEGMTVKHCALSLVGEPIM
YPEINRFLKLLHEYKISSFLVTNAQFPAEIRSKAYDSLLTVLLPRGVFTVSVLKDLWKIE
ANRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKLLSPQLDSLHMS
EFHTMSSTAHFMAGEIQCMREILKSFHTNICST
>A0A7J6N5C8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus olseni|TrEMBL
MLAGGFYHALLSKHYSGPSRTVKVVYSSRTGTSKAAAGRLKDTLESDKIRVILLPIEQYS
YEELCEESYLVLLLSTDTDGTPLPGAKDFTEQLRDAVYDFRVDKNLLEKCKVAVIGFGSE
EYPAKHYCKVAKNCDDWLAKLGAQRVSPLLCISDTRDVEKQVGRCIDLIKKAYARLDVEP
TDQRTADLEDDVESVGSEESTSDTEDGDVEDASGACGSSNKEMVTKKHRAALTREGYRLV
GSHSAVKLCRWTKHQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPVG
RSWTWAQDPPEEIVDGWLGNHAGMIKELRGVPGVTPERFEQAKKVRHCALSLVGEPIIYP
QINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAKDMKAIDRPLFEDF
WDRFIDSLTALKHKKQRTVYRMTLVKGYNISTAAEYAELLHLGNPHFLEIKAVTFCGKGD
GSAQMTMENVPWFEEVVEFAQMMIESSPWVKERYEIACTHRHSCTVLIAQKSFKVDGVWH
TWIDYDKFTQLALDYSKTGKPFAVEDYWAPTPAWAVYGAEEEGFDPEMKRHYRNGKTPEL
GKQIRAKQLREEQERSSKCGEGTECCGGGCREE
>A0A6P6ED52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Octodon degus|TrEMBL
MDPSLDVWTLASPLVSLWMYRFYIYLGFALGISLWICFQVLTKKQLFIFKAKNSQEKSVP
KATQGLMTNGYIALQKKQTFVSGVKIFYGSQTGTAKGFAAILAKAVASLDLPVEVINLKE
YDPDDHLMEEIASKNICAFLLATYTDGRPPESAEWFCRWLEDAASDFRFGKTYLKGMRYA
VFGLGNSAYPSHFNKVGKSVDKWLWMLGARRVLARGEGDCDVVRSRHGSIEADFTAWKAT
FISRLQVLQRGEDKACGGRCKKGKCDSTPHGSEEPGPGPHSGGGSHPGDAEEQEPCESSS
EEDLEPGGHPGLNSIVDVEDLGKIMSHTKKEKGEKDHQEEKTSLFRNTRKGDDSEGRAMI
TPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAARFEEGLQ
VKHCALSLVGEPIMYPEINRFLQLLHCCKISSFLVTNAQFPVEIRNLRPVTQLYVSVDAS
TKDSLKRIDRPLFKDFWQRFLDSLKALAAKRQRTVYRLTLVKSWNVDELQAYAELVSLGS
PDFIEVKFKIDGEWWTWIDYNRFQELVQEYEDSGGSRTFCAEDYMARTPPWALFGAREKG
FDPKDTRHQRKSRSKAIAAS
>A0A8J8K518|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Asgard group archaeon|TrEMBL
MTVVPCSIPENVREKLEKQQYRIAGNHSAVKTCTWLKHSLKGEGSCYKSKFYGIASHQCL
QCTPAVIWCNLKCVFCWRSASWYNKEPMNCKVDEPKEVIDQMIEQQRKLVAGYNAHPAVP
NKKYLESLNPKHAAISLSGEPTLYPKLSELIEEFHSRDMTTFLVTNGTNPEILENLDPLP
TQLYVTLIAPNKELFEKTARPSIKNAWDKIKETIQLLPSLDTRKVIRLTLVPGYNMEQPE
EYSKIFMESEAHFLEPKGFMSVGDARKRLPYEIMPRFEKINEFSKAIVADHELQIIDKEE
DSAVTLIAKEDYSWRNLKKTE
>A0A524FQN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPIELRERLEKQGYHLLGKRGAFKACQWQKKALLSGDACYKQRFYGIESHRCVQMAPVVD
KCTQSCDFCWRVTPSDVGISWDQVKVSRDDVVPVDDLMDAVLVANLQSLGGYNPDAGAKV
SGKMYAEAREPKHVAVSLAGEPTLHPQISELIDEIHNRKMTSFLVTNGTRPDVLERMTAP
TQLYITLAAPDESTYKRLCKPGIKDGWQKIGESQELLQSFNTRTVNRLTMVSGRNMENPR
PYSDLILKGEPDFVEVKGYMFLGSSRGRLTSENAPTHRDIRAFSQKLADLTGYHLLDEQI
ESRVVLLSQSKHIKKLQ
>A0A2P2IEV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hirondellea gigas|TrEMBL
RRKSFYRRDAMGSTTSKDIPKISRHELASAEGICCAIDGKVYDLTRFASLHPGGEEVLRE
VSGTDASEEFEAAFHSENAISLMDQYCIGELVDTAEVPSPVGDSSCSDALPDPSVSSASV
EPITKECCSEEPNSQQIHVKVLYGSQTGTARNFAKSLALQIGGRFEGKIRSSTAIAMDDI
DPEDLSSESLIIILLSTYSEGNPAKNAEFFSNWIRDAVSDWRVDNSFLRKLRFAIFGLGN
SLYSDHYNEASRNLYQWLRKLSAHPLLPPYDGDNSIERSDSGSLETDFQSFGESLLSQIE
LAINDPSYFPDDVEVPEVKEFEDVPENLQYEDLGDEDEQKVQDQESSLVDLEELGSVMKE
QKKHKEQLVEEKKKEILREMVTPALRRNLTKQGYRIIGSHSGVKMCRWTKAMLRGRGGCY
KHTFYGISSYQCMEMTPSLACANKCVFCWRHHTNPVGREWRWVMDPPEFLLEEATKNHRQ
L
>A0A6B0VJR4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum halalkaliphilum|TrEMBL
MSDSADSGVEPGTDAGTDADREGEDGDGGPMQVSSPDYHSENHTAAQTCGWTANALRGEG
KCYKNIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASIRL
QKRLLSGFGGNDEVPREVFEQSMEPRHVAISLDGEPSLYPYLPELIDAFHDRDITTFLVS
NGTRPEMLRECDPTQLYVSVDAPERHTFDEVVGAMEDDAWEKLLETMDVLAEKDETRTVL
RTTLVKGENMHHPDWYAGFYQQADPDFIEMKAYMHVGHSQGRLDRSAMPDHEEVVEFTER
IGEYMPEFTELKEVPASRVALLSKTEDTWVPKLKKDSEFWARDPMTGD
>A0A662KWM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MHLSQDLKRILENQGYALVGKHSAVKLCHWLRKSLLESKACYKNTFYGIESHRCLQMSPA
AFHCTQKCLYCWRFQGFTLTELKKEEADEPAYILERCIEEQRRLLTGYKGDERVDLKKWE
EATEPKHVACSLTGEPTLYPFLSDFFEECHKRGMTTFLVTNGTNPEALENMDVLPKQLYV
TIAAPNEEIYKKLCCPLIPKAWEKLNETLELLPSLNTRTVIRHTLVKNWNLGYEKEYAKL
DMKANPWFIEPKGYMFLGYSRQRMTLANMPSHEEIKKFGEKLAELTGYKIEAERKDSRVV
LLGREKERRIK
>A0A7L3K9A5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Drymodes brunneopygia|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKQSHRNPTSSEG
AADKLGNGYATPQAQEVRVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLAEEASSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYEDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKECSDPEHGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIVGHMKKAKVLLHCGYQLVYFVCQFLQAKLSHCLMIFAVFSGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYP
HINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDF
WQRFLDSLKALAEK
>A0A7L3NF86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreotrochilus melanogaster|TrEMBL
VPMDAWNFFSTCLVSLWLHRFYIYSAVAFGISVWIIVQFFTTKTKKKFTEHGEKANGTLA
GGTEDKVVTGSAPLQAKEIHVAGVKIFYGSQTGTAKRFARSLAEAVASQDLPVEVISLGD
YDPDDCLVEETTSRNICVFLVATYTAGQPPESAVWFCRWLEEAVNDFRLGKTYLQGLRYA
VFGLGNSAYADHYNTVGRNIDRWLWMLSASRVLTRAEGDCNVAQSKHGSIEADFEAWKSK
FLLQLQALCRGEKKMCSGKCKKGKCKSGGKQSKESSADEHGALEYENTEAEELFESSSEE
EADALEAGGTSSVIDVEDLGNIMSHMKKEKVQRLFCGAGVFHAGSLSDSVCIASDLGFAY
LGTQLGYRWCVLTFLAFVCVLLCHQSMLRGRGGCYKHSFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFRGVSGVRADRLEAAMTAKHC
ALSLVGEPIMYPQINHFVKLLHQRGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKDS
LKRIDRPLFKDFWKRFLDSLKALSEKHQRTVYRLTLVKAWNVDELRAYADLISLGKPDFI
EVK
>A0A103XX06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cynara cardunculus var. scolymus|TrEMBL
MSSTGTATATRISTTSLTTHLTVLAFLSATTLYCFYRSRRLRHLKLSPSSSNPSLSSATR
KGKLFFISQTGTSKTLAQRLAKLLASNNLPFDLVDPNSYEPEDLHQETLVLIIASTWEDG
NPPSNGVFLSNWLSESAEDFRVGSLLLSKCKFAVFGVGSSAYGDNFNAVARGFSTKMRCL
GAMEILPLCEGDVDEGELDKAFGIWSKEVIRVLKVGELSGNGSDLIGENGNENGYEMING
SDYDEDDDYEDEDEENGAESDIVDLEDIAGKAPSKKDVGVITSNGKKNGVKEMVTPVIRA
SLTKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGKSWQWKMDDPLLIVNSAIEQHKKMIKQMKGVPGVTAERLSEGLLPRHCAL
SLVGEPIMYPEINSLIEELHQRRISTFLVTNAQFPEKIVSLTPITQLYVSVDAGTKDSMK
AIDRPLFGDFWERFVVCIFLWHKIFCPYECKCQMHVLYIEIHVDSLKALRDKQQRTVYRL
TLVKGWNTEDVDAYSSLFGIGNPDFVEIKGVTYCGTSATSKLTMDNVPWHADVKAFSEAL
AEKSNGEYEVACEHVHSCCVLLAKVDKFKIDGQWHTWIDYEKFHDLNLLAATNTWPLLHL
GRSMELTKAGLIQNRLGIRKKGITNQAVDRQEQ
>A0A8C3NBL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geospiza parvula|TrEMBL
MDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTSSTKRKPLEKGEQSHGSPSSL
KGASDKLGNGCGPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVSSLNLPVEIINMED
YDPEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRYA
VFGLGNSAYVDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDK
FLTRLQALCKGEKKPCRGKCKKGKCKTSGKQSKESSDGEHGTSEQDNTEAEELFETSSEE
EAGDTDSVIDVEDLGNIMGHMKKAKREQELQEGAGGAERREMITPALRKALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGT
EWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPH
INHLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRIDRPLFKDFW
QRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSA
SSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHCKFQVDGEWRTWIDYG
RFQELVRERERSGGTRSFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKARDTSGC
>A0A0E3L5K6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. WH1|TrEMBL
MSLEERKEEKEGSGESFPEIQEENRDEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMFAKVSPSQLYMSLDAPDLETYLRVCQPKSPSLWDRINESLDIMK
DKCSRTVIRITLVKGKNMFNPEGYAELIKRASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELVKHLGYEIVDESEISRVVLLSKDGKKSPVKKVSCLD
>A0A8C4JHD8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dromaius novaehollandiae|TrEMBL
MDPWNFFCTCLMSLWLHRFYIYSSVAFGISVWICIQFFTSKTRKKGEKFNGNPASAEVTE
DKLVNGYATLKVKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLSAEVINMGDYDPD
DSLTEETTSRNICVFVVATYTDGQPTENAAWFCKWLEEAANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSR
LQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDREHGASEYENTEAEEFFETTSEEESNA
EEAGDTNSVIDVEDLGKVMSHMKKAKRERELEEEGGRASLSQESAGRKEEGERREMITAA
LREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILREAXENHQNMIKQFKGVSGVKADRFEEAMTAKH
CALSLVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKD
SLKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDF
IEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKK
FKIDGEWYTWINYDHFQELVRDYERSGGSKTFTAADYMAKTPHWALFGSRERGFDPLDIR
FQRKNKTKDISGC
>A0A4X1SVQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKVPF
VNPSPEFPYRGGLE
>A0A8D2A5T0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKSLS
VSADVPLMGSQIFLRTSPWTPRCGCPSNPEQGSLRMRKRGAEEPLEGERSRRGAGPPTSP
LGKSSPPNPSRRNKLSRMFTRDLIVFSPQVGGGVGAGSLCAKCLGGGGRERRPPGPDDRG
GVPRGCTSHWDRDLVICLEL
>A0A7C5DY99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MDQEIRNLLRKQRYKIVGEHSAVKLCHWLKKSLMENRVCYKQKFYGIKSHRCLQMTPSVI
SCTHKCLFCWRPTQYTFSTIENPDPPEFIVEKSIEAQKELLSGYWGVLDRVDKEKLKEAI
VPNNVAISLAGEPTMYPLLSDLIDEYKKRNFTTFLVTNGTNPKVLENISLPWNLYVTIPA
PNKEIYKKLCIPQIPDGWERIMETLELFPSLNTRKVTRLTLVKGYNLKNPEEYAKLIEKA
SPEYIEAKAYMYVGFSRLRLNIENMPSFSEIMSFAQQLEAMTNYKIKDSSEDSRVVLLVK
E
>A0A8D1R1C6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRYQR
KNKAKDISGC
>A0A2U9B3W0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTFLKGL
RYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAW
KVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEEDLMESSSDEDESG
LQDEKKSGSVVDMEDLGNIINIAKKAKSKEEGGGGGQVVKLSKMNGVKKIEDEGEKREMI
TPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVKPERYEEGLA
VKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQ
PDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEHEHSNCLLIA
HTKFKVAGEWWTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPGWALFGACEQGFDPA
DMRFKRRNKAKDISGC
>A0A7C5TKX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MQIENMAQRDSVSYAFNVLRKQKYHIIGSHSAVKKCYWVHKALTERLFCYKAKFYGIESH
RCIQFSPSILWCWNYCLHCWRYRSEDQDSNIWNRFPENIDDPRTLVEMAINEHRRTISGY
RKYPNVDLAMYKEAMDPRHAAISLTGEPTLYPRLDELIEEFHKHNITTFLVTRGIRPDIL
SNLRTEPTQLYISIEAFDEDSYKYFNNPISSMLWKKTLETLEILPSFTSPTVVRITLIKS
FNMNLEAIEKWAKILSKAQPTFIEIKAYMHIGVSITRLKRIDMPSHEEVKKYAEILAERI
GYGVVSESRPSRVVLLSRFNKPVIRYGNPPINWYDIDKVDEYQDKYNYLYEVI
>A0A1G4HDX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSKLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSAHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEILSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>A0A7C4HVQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MTVYRMEVEMAEKLRRAGYRIVGRHSAVKICHWTRNVLRGGKHCYKNWYGIESHRCLQMT
PSVQYCNMMCLFCWRFHTINRVVAYEGDWDRPGEIFDEMIKEQRQLLSGFKGNPNVDKKL
YREAIEPRHMAISLDGEPTLYPYLTDLIKLAHSKGFTTFLVTNGTMPERIRELIEEDTYP
TNLYISFYGPDPETHVKLCRPLIPDSWKKIMESLELMSVVEKSRRVLRFTLVKGYNMKDV
EKYCEAVKKARPDYIECKAYMHVGESQKRLPREAMPSMQDIIEFSEKLSNFSGFKIVSKD
FQSRVVLLADESSTWYHRDLENIEKRSRIT
>A0A4W2H5Z1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos indicus x Bos taurus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALRKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHQSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>A0A1A8HL59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius korthausae|TrEMBL
MLRLLVFLSHITAHVASADTNAQQEAPRSGESYLLWVWTNRLYVYSAAALLFGTWFLLKV
TQQEKHTDSAGPSSTSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVD
MKNYDPDDQLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAW
KVNLLGRLQALAKGEKKSCSGTCKGGSSCKDKKEDVTSQDASAEVDRIESSSEEDESGLA
DERTSGSVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDEERREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCAL
SLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
KIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEV
KGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKV
DGEWWTWIDYERFQELVVLHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQR
RNKTKDVSGC
>A0A846PX59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MNMSKLRIEPKIEKQLRNAKYGVHNHSAVQICTWTKKSLHNEGFCYKQKFYGIDTHRCME
FSPSAVFCGYNCIFCWRPMEFMRFRGMEADEADDPREIYERLLEERRKLLSGFPGDGKTD
MKKHEESLKPNHFAISLSGEPTIYPKLPELVEFLKNLPETRSVFIVTNGQEPEMMAKLSK
SPPTQLYLSVNAPNQMLFEMINRPSSENGWERFLRSLGIFSKMETRRILRLTMIRGMNMD
PPYIKQYADLIQKANPHFIEVKAYMWIGFSRNRLRERNMPSHEDIRNFSKEIEKITGFKI
LDEKEDSRVVLLANEKEKIGKFIK
>A0A072P199|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala aquamarina CBS 119918|TrEMBL
MDIGEGGAMPVILVDWMDRGLTIWHDHRVVVSSFILAVGLLAFFVRRRQGVRVTQPTSPP
LTAKTDWLPKAGAETQTKSLTQLISHGSAQQYNLRSANSSQKGKPRAAARVVTGRKPAAT
GTGKTVPAQSEAPSIQPLIFFSSLTGTTEQLSKEVSSRLESLSTQTPAVLKPEIHDLSYI
DLDDYFISGPKSSTHPLRPSTRFFYLLLIPSYDIDTILNTFLSHLDETHNDFRIDASSLS
VLAGYSVFGIGDKEGWTSEEKGFCSQALEVDRWMAKLTGRKRAYPLGLGDVKSNVKQALD
DWVNGVSSVLEELSSTGSLGDGVPGSGEAVESEDEEEVLEDDTEVDFPDSGRNKRRKLAK
TTDLEDLGGTGGLPLAVDFTTYSSPTNQNAAVPLKAMVPKESPTYAALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWR
WEVDDPQMIFDGAKEGHYKKIKMMRGVPGVRSDRFEEAMRIRHCALSLVGEPIFYPRIND
FVGLLHSEHISSFLVCNAQHPQQLRELTRVTQLYVSIDASNRDSLRKIDRPLHRDFWERF
QTCLDILREKRFVQRTVFRLTLVKGFNIDDEVEGYADLVAKGLPCFIEIKGATFTGPASS
LTMQNIPFYEEVVAFVEALDRALANRGLEYGIAAEHAHSCCALLASKRFRINQRWNTIID
YEKFFTLLDSGADFGPEDYCAETPEWALWGNGGFDPRDERVDRKGRPKENKVTVAQDLRK
NDEGNAAKGEIQF
>A0A421DZT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. Atlit-120R|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFEQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRRTFDSTVQAMEDDAWDSLIDTLDVLAEKGDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMSEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A7L4PLH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MEYLPEQMAAGLASQGYHLAGHAAVKPCLWLKRSLRGGDQCYKHHFYGIASHRCVQMTPT
LHCNHLCHHCWRPVDQPIAPPREWMEPGELLDGILKEQKRLLSGYGGSEVVDRVRLEEAA
RPAHVALSLMGEPTMYPHLDELVEEVRRRGMTAFLVTNGTRPEVLERVRPTQLYLSLNAS
DQGLYEQMAKPASPGLWDRILESLAVLKDHPGRTVVRMTLVRGLNMDDPAGYAPLLEEAR
PDFVEVKAYMHLGRSRNRLSRDSMPEHQEVLEFASRLADLMGYVLEDQVPLSRVALLTGG
TADRIIAES
>A0A7L4Q612|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MQDTMAEKALARQGYHLVGSGAVKPCLWLNRSMRGGDQCYKNHFYGIASHRCVQMTPTLE
CNHLCLHCWRPIDDPIPGKEPMEPAELLEGILRGQQRFISGYGGSSTTDPVRLEEAREPK
HMAISLMGEPTLYPYLKEFIDLVSRRGMTSFLVSNATRPEVLAELRPTQLYLSLNAPDEE
RYRQICNPSKDLWPRILESLELLKEHRCRSVIRMTLVRGQNMEGLDDYARLIGDAEPDFV
ELKAYMHLGRSRTRLERTAMPQHSEILALADSLAGLLGYHPEADVPLSRVALLSRGRISR
FIEMRDHK
>A0A1J1GPS3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium gallinaceum|TrEMBL
MMDIFQNFFKIILKHYLYNSKAKISIKLIYGSESCNSYNNAENFLIELIEFFKEIDNFYK
DIKKYLYENNNNINDISNLEKYLLEYFKFHLNNKIDLKKKKNNGIIRRKYNLQEYEKDIK
NSKENFKNYLDYFIETNLTLVYFDFIEGNEFDCDTYFEKLHDYDLNILLLFVSTYDNGSF
PKNCCKLEETLKDLINDFRVEKDLFKDVFYSCVGYGNKSYGKKYFCSPIIKCDKWLFSLG
AKKLYKTLTLCDGENNEDYILDWKCNLFKTLYLSLFFYCFNNIKLFTFIYYPNLKKYDSL
KFYCSFFCNNYNQIFENVYNTQNCSNNIKPNEINKNKELHDLKNLIYYHNNKENDSFLNK
KDHDKKHINNFNTDENTETNKQICNVYKNEKNSFEEDTCNNYATSNVCKNSKNKLEYNYE
ESTKIISSESSYDEKDYEKTKNILITNSNHNNKDASINCSSEDELEDLVLNETKDMLTKN
QRDKLTKEGYKIIGSHSAVKLCRWSKSQLRGRGGCYKHTFYGINSYQCMEATPSLACANK
CVFCWRHHKNPVGVSWKWNKDEAKMIVEEAIKKHKGMIKELKGVYGVIKERFDNAMNIKH
CALSLVGEPIMYPDINELIDELHKKNISTFLVTNAQFPDALKNLRKVTQLYLSIDASNKE
ALKNIDRPLFKDYWERYIKCIKILKNRKERTVFRFTLVKEYNMMANEVSSYAKLIEYGSP
DFIEIKAVTYCGTSNGYQLTMKNIPWHEEVYQFAYHLINCKSSLTNIYEICCEHKHSCSI
LIAKKIFKINNKWFTWINYEKFQYLVKQNKDFNAVDYCAETPEWAIVGSVEKGFNPCDKR
VYTKGKNKNRNSNKNQNEYEKKV
>A0A843CEZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MEPRATLNYYKETLKTLEKQGYHFVGTHKHSAVKTCLWLRRSIRGEGNCYKGKFYGISAH
RCIQMTPSIFCNQSCVHCWRPLEAFNIVGEVEPVIWDAPDEIVEDCIKEQNRLISGFKGS
DKTNMDAFAEATVPKNAAISLIGEPTLYPHLKGLIQEFHSRDMTTFVVTNGTNPGVLREI
RPYQLYISLNAPDEATYKKASHAQYWPRINESLEEMRKLKGRTRRVIRITCIEGLNMINP
AGYAELLERANPDFIEVKAYMHIGYSRKRLSREAMPTHLRVKDFAREIAEALTPLGYTYT
ITDESEISRVVLISSL
>A0A8B9ZAJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Buteo japonicus|TrEMBL
MDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIHLGCCGEKSNGNPASFEGIEDKVVNG
YATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLSLPVEVISMGDYDPDDCLSEE
TTSRNICVFLVATYTDGQPTESAVWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGNSVYV
DHYNTVGRNIDRWLWMLSASRIMTRAERDCNVAQSKHGSIEADFEAWKAKFLSRLQALCR
GEKKPCSGKCKKGKCKSLGKQSKESSDHEHGASEYENTEAEELFETSSDEEADGEEAGGT
NSVIDVEDLGSIMSHMKKAKRERELAEGDTGTSLTHKNAGRKEEGEKREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLV
GEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTKESLKRID
RPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGEPDFIEVKGV
TYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKINGE
WWTWINYDRFQELVREHERSSGSKTFTAADYAARTPHWALFGSRERGFDPLDVRYQRKNK
TRDISGC
>A0A3B5LZ00|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xiphophorus couchianus|TrEMBL
RSVIGQETAIGAPLILTLYFIYLCFILCCVSKSVCVFLVATYSDGRPTKNAEWFCKWLEE
ASTDFRYGNSFLKGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSAKRVLSRGEGDGNV
VKSRHGSVQADFRAWEVRFLSRLKALARGEKKSCSGNCKSGASCKNRKKHGAQEEEENGS
EKNKRFFFLFQVELIESSSEEEESGLSGEKMSRSVVDMEDLGNIMNNVKRAKVRFHPRSK
RLFELHMLEKMCDQVKSFFSILLKLLLLLVSRFVSNRHHTNPVGTEWRWKMDPAEKILQD
SLEKHQNMIRQFRGVPGVKPERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHHISS
FLVTNAQFPEEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQ
RTVYRLTLVKAWNVEELQAYAELIALGQPDFIEVKVRLITQKHCFLAPFVGYTTRTLVVI
ATDNNFKVNGEWWTWIDYDRFQDLVQAHEDSGGQQSFSALDYTAKTPSWALFGSNEQGFD
PADTRFQRRNKTKDISGC
>A0A2J4G9X1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp. NZ13|TrEMBL
MMSQERLDVQRYLRAGYRLVGEHSAVAVCRWTKSAMRGERLCYKNWYGIQSHRCVQMTPV
LNFCDFSCKFCWRMQQPGRFKIPPNWKWDMPDEIIDGSIIAQRLLLIGFKGNPRVTRERF
LEAMFPRHFTMSLDGEPTLYPMLPELIKRVKERNMTAFLVTNGSIPVRLEQLIKRDAQPT
NLYVSVYGPNEEVFNYTAEPKIPRAWEMVQRSLEILNRFTESRTVIRFTMVKGVNMTDPD
GYASLVKLGNPMFVELKGYTWVGESQKRLPISAMPTQDEMLKFAEEISRRTGYQIKLTDE
KSRVVLLVRDEDAWERNLKMREEWFKRVEKLDEKWKSKVEDFTMEEHGYKILNY
>A0A663ENT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aquila chrysaetos chrysaetos|TrEMBL
MDTWNFYTCLVSLWLHRLYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASFEGIED
KVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDYDPDD
CLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFGLG
NSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRL
QALCRGEKKPCSGKCKKGKCKSPGKQSKDCSDHEHGASEYENTEAEELFETSSDEEADGE
EAGGTNSVIDVEDLGSIMSHMKKAKRERELEEGDTGTSLTHKNAGRKEEGEKREMITPAL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKF
KINGEWWTWIDYDRFQELVREHERSSRSKTFTAADYAARTPCWALFGSRERGFDPLDVRY
QRKNKARDISGC
>A0A194VWR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Valsa mali|TrEMBL
MEFEPFGVSPWLAQLSDSVVEYWHANRTAIILAALTILIVLRLYFHFTEGTEPLHVFPKI
YDAEDKPVKVEEKVEVVTRNKPDGPRRIKGELTKRRSTEAPTGRRQIKTLIFYSSLTGNT
EKTAKEFVKTLAGLLKGVTTSATCDFSQPEALDLAELDLDEYFITPPKLEEQEDVTTDLF
YLFLLPSYNIDSINDTFLEHLNETHNDFRIDTAPLAPILGYSVFGFGDKEGWPTEEAGYC
FQAKELDRWLAKLTGRKRAYPLGTGDLKGDGIQRLSEWTNGLLDVLGQLARDGTLGDGVP
GSGDAAESDDEADVDDDDGEVVFEDDSQPKSTKPKSSGTLEDLEDLGRILQNAKDDGAKP
AAPLAIDFTTTTSKRKQPVQTVKEMVPKNSPTYNSLTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWVVDPPDLIFNG
VKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLEMLHGDRISS
FLVCNAQHPDQLAALNHVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILREKRF
KQRTVFRLTLVKGFNIEDEAKGYADLVEKSLPCFVEVKGVTYCGTSTSSSAGLSMANVPF
YEEVCEFVTALERELKRRGLNYGIAAEHAHSCCILLGSERFKVDGKWRTQIDYDRFFDLL
EERGPDGDFTPEDYMGAETPEWATWGNGGFDPRDQRVDRKGRPIER
>S7V3V9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii (strain ATCC 50853 / GT1)|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKVRGKAKPEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGEYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A6A7LE26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeraceae archaeon|TrEMBL
MSCSGEYTSHNSDNNLIQIDSNARSKLLNAKYGVYNHSAVDLCHWTKKSFAHEGDCYKRK
FYGISTHRCMEMTPTALNCENRCVYCWRPTEFYDTLMMPENLVDEPDAIVENLLQERRRL
LTGFYGHKKYDKGKLDESLFPQHYAISLSGEPTMYPKLPALIRYLKKLPMTKSIFLVTNG
QEPQMLDRLAEEKSLPTQLYLSTNATNRLSFARINRPRHPDAWERWLKSLQFLSRCETRT
VIRITLVRSHNFNYETIVQFCGLIPRANPHFIEIKSYMHVGMSTQRLERQNMLEMEEVRR
FSAQLCEKLPGFNVMDESEISRIVVLQNKNRHTDRFISSYLHQGCTA
>A0A7C5SWU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MVRRRKSEINVEEARKDPYKVLFAILRKQKYHVVGHHSAVKICHWTKAALLENRFCYKCK
FYGIESHRCIQMSPAILWCWNACIHCWRLRPQDVGVEWDETRLPVVDDPKVIVDGVFREW
YRILSGYRGNPKADKKLLEEAYKPKHVAISLTGEPLLYPRLGELIREFHRRGLTTFVVTR
AIRPDVLANLEEEPSQLYVSFEAWNKEMYQKLNVPLAPRAWELSLETLKLLPSLTCPTVM
RITVMKGINMGDEDVKGFAKLIDLAQPTYVEVKAYMHVGASTKRLPRETMPAHAEVKEFA
KKLAEESSYPLVSESIPSRVVLLSRLKEPIRFGKGCPGGWRTPDIGGEESGEYGKYMKEA
F
>A0A3M7PXN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brachionus plicatilis|TrEMBL
LNDVPFILAKMNRISNETNSTDPSKKDDNSSQPAVIVAGNDSIKLMAESIGINNMSEEAC
RELANDLTFAIKSILLDAQKYCRKSRRKMLNPSDIDYALKIRSFEPIYGFYSNDQIPFRC
STMTGGNGGGRCVFYVDDQMLDLNEVISLNNSSIRLPNDFVIDAHWLAIEGVQPSVPENP
QLVSRDIQKQEAIEGASVKSKEKIGLPIQKTNIGENLVKLKNLVPHDLSMEQQFYFKEIT
EACVGADEQKRTEALNSLSIDPGLHQLLPRFILFITEGVRLNIVQLNMAILIYLMRMAKA
LIENKSIYLEKYLHELLPSIFSCLLSKQLCARPDYDNHYALREFSALLVGQVLKAYGSTL
TFLQSRIINVYVSAIKSEKSLFSTLFGAIVGLAELGDDQIFESVVLGMVKPIGEKISQVL
DGNILPNEKLAAERVKLELIKIISKIFASKSTEIESNYLNEKFGSFIGQLIFLEINKTKN
QSTKAKNQEIDKEPKRQANEVNMSKSSSGQSEDCEKLLTAASGIGLVMELKSQLRGSGLN
ELKLWPGVKITFFSSVVICMFVKWLRKRKIQIPRENLILVDTESKLSIKILYGSVTGKSK
YFAEDFAKACSARGITQTSVTNLKDYDPEDNLLNEISPDNILVIFVSTYTDGAAPENASW
FYKFVTEMCHDFRYEKASLKGLNYSVCGLGNSLYEDNFNKVAKELDKAFSILQATRVAPL
YCCDENTIKSKHSSLEGDYDFWKNNFFEKVDHLKKEEQNPEEKPEEKPETKYEDTSDGED
NQSQSDEYVSDVDDDLNNNEDSAKVKKSNGVLDMEDLGTVIKKVKEKKISSEPKEMITPL
LRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWKWKMDDPELIFETALKNQYSMINEFKGVPGVKKERIEEALNVKH
CALSLVGEPIMYPEINRFIDLLHSKKISSFLVTNAQFPEAMRNLKPVTQLYVSVDAPTKE
SLKRIDRPLFKDYWQRYLDSLRVLNEKRQRTVYRLTLVKGWNTEEIEQYASLISLGKPDF
IEIKGVTYCGESNASTLTMQNVPWYNEILGFVNQMQEKLAHEYEITCEHQHSNCLLLSHK
KFKINNEWYTFIDYEKFHELVKDYGENGTQFTSLDYIAKTPSWALFGSKEAGFDPVEERH
MRKKKKDISGC
>A0A3A5VM62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVSSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVARHTLMKGINMSDEHIRQFAALDN
RADPDFIENKGYVFVGHSRENLSVENMPSHDDIMEFSSKIAPLTQREVLSDSRPSRVALV
GREISPIPIPEATMFFPEDLGIAPPVKHLPMAS
>A0A3A5VM22|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGIASHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYAHLSEYMDLCHQHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDTHINEFAALDN
RADPDFIENKGYVFVGHSRENLAMENMPSHDDIMAFSNTIAPLTNRRVLSDSRPSRVALV
GTEIVPIPVPEATMFFPEDLGIAPSIKHLPVVS
>M1IYH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus acidocaldarius Ron12/I|TrEMBL
MEGQLKIDTFSVIMKELEKEKYHVVGSHSVYKKCHWTHEALTTGRYCYKGKFYGIESHRC
VQMSPSAAWCWFRCIHCWRLEPEDIGIEWDETKIPIEDEPEIIVERSIEEHKRAVSGYFG
RNGVPKNKVIDAATPRHVAISLTGEPTLYNRIGELIKEYHRKGLTTFLVTSGVRPDILAS
LEEEPTQLFVSIQAPNYKKHKIMNRPIVPNSWELFLETLKILPSFSSPTVIRMTMIKGYN
MSEEDAKDFAKLIELSQPTYIEVKSYMHVGPSTYRLTKDAMPKHNEIREFSKILANYTGY
KIISEHVPSRILLLSRLDKPIQIGNAWTDKWNWSTKDTEDDMNGEYKEAEESCTEGGI
>H9FWN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca mulatta|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKSMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A1I4T258|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus profundi|TrEMBL
MSRRRKKDIEITDFKSLLKKQGYSLAGKHSAVKTCLWLRRSIKDEGECYKSIFYGITSHR
CLQMTPTLICNQKCLHCWRPTDIDVTMPVGYDSPEEIVRSAIESQRRLLTGFGHSAPPHL
WKEGNDPKHVAISLSGEPTLFPHLPELIEEFKEQDFTTFVVSNGTVPEMMERIDPAQLYM
SLDAPDRETYEKVCVPDSPKLWDRILRSLEILRDKETRTVIRITLIKDVNMFSPEAYAEL
IKIAEPDYIEVKAYMHLGFSRKRLPREAMPSPEEVLEFSEELAEHLGYKVAGNVEVSRVV
LLSKDGSVTHLV
>A0A319FFH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus sclerotiicarbonarius (strain CBS 121057 / IBT 28362)|TrEMBL
MAETAAAEGLLAFWHSYRLPLLLALATVIVLLRAYRKVQPKSKIATASSIPSSPRSQSPE
KSEKIASNHEKEIEKESNAQVVEKESAKPGPKRVTGKKPAKVAGRRRGSDQEPAVSFIQP
IIFFASLTGNTERYAQVLLEELRAAARDRADPENRERALLPPQIHDLSYVDFDDYFITAP
KPPSTSPGTRYVYCMLVPTYNIDTVLNTFLGHLDETHNDFRIDTAPLAGLAGYSVFGFGD
KEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFADVKSDPESALKEWSRGLQDILGD
IVDHGGLGEGVPGSGDALESDEEDLDDEESDSKANGRKRNKAKSVVDLEDIKFSAETGSS
APIPVDFTTGGKPAAPATEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVKE
GHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFLV
CNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQR
TVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEE
VQQFVTSLNKELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEKE
KADGTPFTPEDYMKETEEWAMWGNGGFDPNDERVYKKGKKKAIQAAAEAQG
>A0A2G9PAT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon CG10_big_fil_rev_8_21_14_0_10_43_11|TrEMBL
MVDEKLALAPKIREQLVKKKYGIVGEHSGVQICSWNKKSLRQESVCYKQKFYGIHTHRCA
QMTPTVAWCTERCVFCWRSNEFYKVTDIKKNQVDTPQQIIPGILKERKRLLAGFKNHPKV
PMERYEEGLIPTHFAISLSGEPTMYPYLPEMIQHLKEEHGARSIFVVTNGLQTEMIQRML
DENSLPTQLYLSLDAPNEELFKKVNKAVVPLAWKKLNDTIDLYPKLPCRRVVRFTLIKSI
NDAEDLFKDYGAIFERTHTDFLEIKAYMHLGYATKRLSHDNMPTHDEVKAFTHRVLAHLP
NYEVCDESVPSRIVLLKRKDSTYTNRIYPDEDNTPAWVKNKKSMDEDGTDEFMP
>A0A1D2WR44|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. A14|TrEMBL
MPLEENKENAGENFPEAQNKNRKEDTASLPFDIPDFKTLLKKQGYALAGRHSAVKTCLWL
RHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPEKIV
EESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIKEYEKRGF
TTFLVTNGTVPEMFAKVSPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSLMKQKK
SRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVL
EFSQELAKHLGYEVADESEISRVVLLSKDGRKSPVNGKKISC
>A0A7L3JMR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thalassarche chlororhynchos|TrEMBL
LDVSMEMWNFFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKTVTEHGEKSNGN
PASSEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
SMGDYDPDDCLSEEVATGGNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLK
GLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFE
AWKAKFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFE
TSSEEEADAEEAGGTNSVIDVEDLGNIMSRIKKAKRERELEEGDVATSLTRENTGRKEES
EKREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEA
TPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADR
FEEAMTAKHCALSLVGEPIMYPEINRFVKLLHRHSISSFLVTNAQFPDEIRNLEPVTQLY
VSVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAD
LISLGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHS
NCLLIAHKKFKINGEWCTWINYDRFQELVQEHERSSGSKTFTAADYAARTPHWALFGSRE
RGFDPLDIRYQRKNKARDISGC
>A0A367XUG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida viswanathii|TrEMBL
MGVGSVLLGACSVLYLITGGRWTVVLLGVVLSALYKIEKLNHQVASSPQPAEAKENSTKK
ALAKESPIYAVDFTSTSFTPTSTTVIPKQAVRSRAKRSPKIIKASRPRSPDQEASQSPVL
TRSTIELKKSQIYIFYTTLTGASQRIAKSLHEKLSSLELEKTPKLLSLDDDVDDLEEYFL
KVPQDNAIYLMVLPSYETDSPIDYFLEHLIDTFQDFRVDKYPLRKINGFGVLGLGDSESW
GGEKFCYQLYPLGQVCMKYEGDPKAQEWIQNFATLLDNDEPFYVDENDEVDDSDAEDGSD
DADTLVDVEDMGDIIRKSGKTVTTETKEMVAKDSPTFKSLTKQGYTIVGSHSGVKICRWT
KSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWEVDPPE
KSWLMDRFEEAFQVRHCALSLVGEPIFYPYINEFVGMLHQQHISSFLVCNAQHPDALAKL
AKVTQLYVSIDAPTKKDLKKVDRPLNSDFWERLMSCLDILRTTQSHQRTVFRLTLVKGFN
MEDIESYADMVERARPSQIEIKGATFCGSSTGNGNPLTMQNIPFYEECKRSLKA
>A0A497T009|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIINEETIKKLEKIGYRFAGPSKHSAIKICNWTRESLRGRNVCYKEKFYGISSHRCLQMT
PALPFCTQRCRFCWRDTNITYPEWAGPIDDPEQILDDCINAQREILQGFKGNPKVSEKKF
KEAMNPNQVAISLAGEPTLYPKLPEFVDLVNSRGMTSFLVTNGTRPEMIERLLEHQPYQL
YITVAAPDEEIYKKTCQPIISDGWTRLKKSLSMLSQFNRSVIRLTLVKGLNMIKPEQYAE
IIEKTNPRFVEAKAYMAVGFSRERLGLKFMPRHEEIMKFAEAIEQNSSYKITDEKKESRV
VLLTK
>A0A7C0YX25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MILSEEDIQKMEKIGYRFVGKHKHSAVKVCLWTKNSLVGKGVCYKQKFYGIQTHRCLQMT
PALPFCKHRCLFCWRNTKITYPEWRGPVDEPDEIIDGCIEAQRELLTGFGGNEKVDKKLW
KEAQNPNQAAISLAGEPTEYPLISELVEAFKERGFTVFLVSNGTNPEVIEKLAEPTNLYI
TLPAPNKEIYKKTCIPVVDSWDKIMKSLGLLKNFSCRTVVRLTLVKGLNFVNPEEYAKIV
EKYEPDFLEVKSFMSVGFSRERLPYERMPLHEEIKEFAKKIEENCSYRIVDESKPSRVVL
LKK
>A0A139HQF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudocercospora musae|TrEMBL
MQHSSLLQLPEELLLLWHAHRIELILSAGVLLAIVRLTLHWRGTRAKIVLTPLASPVGEK
KAFPETEHVEKVAVQDEPQVKIQIKAKGPKRVQGVRSVKPKQNGAPAFHRIQPYVFYFSL
GGSTRAHAEQLASDLPRDEKRLSPIVHDLTEIDYDDFFISPPKQESSTTAAFYTILIPSY
NIDTELTNFIDHLQETHHDFRIDTAPLSGLAGYSVFGIGDRIEWPTEELGYCAQAIEIDR
WMAKLTGRKRAFPLGQGDAKGDDLELRLEEWSQGVRSIMQDLSEGKGLGEGALGSGEALE
SGDEADGDDEGETPLKRKGDAADLEDMKAPIPVDFTTTGKKSSQPTEPKAMVPVTSPTYT
SLTKQGYTIVGTHSGVKTCRWTKSALRGRGSCYKFSFYGIHSHQCMEATPSLSCSNKCVF
CWRHGTNPVGTTWRWQVDEPELIFDGIKAGHYQKIKQMRGVPGVRAERFAEAMRIQHCAL
SLVGEPIFYPHINQLLAMLHAEHISSFLVCNAQHPDQLATLGPVTQLYVSIDASNKETLR
KIDRPLHRDFWERFIRCMDILREKRFTHRTVFRLTLVKGFNVDEDAKGYADLVERALPGF
VEVKGVTYCGTPTAAGAGLSMQNVPFYEEVAAFVASLEKELNSRGLEYGIAAEHAHSCCI
LLADRKRFYKASKTDGTKRWHTIIDYPAFFRCVESGRPFAPEDYVGEATPEWALWGNGGF
DPRDERVDRKGRPKEMTTKVGGGKIVGL
>A0A8C4SDW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erpetoichthys calabaricus|TrEMBL
MSAMWLLSTAFMSLFFQASAAQQKDNLDNPWDYFHACFFSLWEYRLYVYLALTVSICIWI
VAQKIQKRKEFGNPENPFQNENFVQKQSIHVSGVKIFYGSQTGTAKRFANDLAKQVEGLG
LSSDVINLKEYDPEDSLAEENTSQSVCVFLMATYTDGKPTENAEWFCKWLEEASADFRYG
KTYLKGLRYAVFGLGNSVYTGHYNTVCKNVDKWLWMLSARRIMTRGEGDCNVVKSKNSSI
EGDFAVWMAKFLKRLQALAKGEKKVCTGKCKKGKCKNKKSHAKEKEVQETPGSENEFETT
SDEESGHEEEASHRAVIDVEDLGNHMKRAKKILEVEDHHAEVQVSKQAVSNNDHSDVREM
VTPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHQCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEKILEEAIENHKNLIKQFKGVPGVKLERYEEGM
SVKHCALSLVGEPIMYPEINKFLKLLHQKKISSFLVTNAQFPEEIRSLQPVTQLYVSVDA
STKESLKKIDRPLFKDFWQRFLDSLKALEGKQQRTVYRLTLVKSWNVDEVKAYSELVSLG
KPDFIEVKGVTYCGESSASNLTMANIPWHEEVLYFVQQLADLLPDYEIASEHEHSNCLLI
AHRKFKVEGKWRTWINYERFHELMKEFEKSNGLKTFTAEDYTAETPSWAVFGAKERGFDP
VESRFQRKNKAKDISGC
>L9WQU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum bangense JCM 10635|TrEMBL
MSNSAETGVDTGSDAEQNEGDGDGGAMQVSSPDYHSENHTAAQTCGWTANALRGEGKCYK
NIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASLKLQKRL
LSGFGGNEEVPREVFDQAMEPRHVAISLDGEPSLYPYLPELIEAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMDVLADKDETRTVLRTTL
VKGENMHHPDWYAGFFQQADPDFIEMKAYMHVGHSQGRLDRSAMPDHEEVVEFTEQVQEY
MPEFTECKGVPASRVALLSKTKDTWVPKLKKDSEFWARDSVTGN
>A0A8J4GGL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Volvox reticuliferus|TrEMBL
MRAARRRKAPSFSAEDAASDFRLGSAALSHLRFAVWGCGNRLYEEHFNVVARRMDRQLRE
LGAKRFRPLGLGDEDADLDLRQQFVPWAKVLVERELQRWQQQQQQQPTGPAVKVSANGPA
VTTAAPGTGAGATEATPTTEVDAVNPDMEDEEYEEEEEEEEEEGAGSEMDMEDIGGAGPR
RGKARTGAGAGAASAASSGPESGPPEMLNPLIRTSLTKQGYKLIGSHSGVKMCRWTKSML
RGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKTWKWRMDPPDTIVET
ALDLHTRMVREYSGAPGVKPEAVAEGLQVRHCALSLVGEPIMYPEINALVNQLHSRGIST
FLVTNAQFPDRIEQLNPVTQLYVSVDAATPESLKAVDRPLFSDYWDRFTACLSALGSKRQ
RTVYRLTLVKGWNMAEVQAYASLVDLGRPDFIEIKGVTYCGSGAASSLTMANVPYHADVV
EFGQAICAARGGEYALACEHAHSCCILLARVDKFFVDGQWHTWIDYDKFQRLVREGNDFG
AEDYMLPTPSWAVFGSEQAGFDPEQMRVRKVRRHPGKSDSAVASVAGEAVDEDS
>A0A2R6KE19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_9_67_15|TrEMBL
MSESDGPKQVDDPDYHSENHTAAQTCGWTANSLRGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPSAVADASLKLQKKLLSGFGGNEEVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFRDRDITTFLVSNGTKPDVLAECDPTQLYVSVDAP
DRWTFDDTVKPVEDNAWERLIDTLDVLAEKDETRTVLRTTLVKGNNMHHPEWYASMFQRA
DPDFIELKAYMHVGHSRGRLDRDSMPEHEEVREFTEDVMEHMPEHDYLNDVPVSHVTLLS
KTEDTWVPKLRKDSEFWARDPYAEVSE
>A0A836BGW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGETVDSEYELIRIKPQIVQQLRKAKYGVSDHSTVALCHWTKKSFKNEGDCYKHKFY
GISTHRCMEFSPAGMYCENRCIYCWRPMEFYDSLKMEPEKVAEPEELVTKLIEERKKLIM
GNYGDSRKDKQKLDESLLPQHYSISLSGEPTMYPKLPDLIKYLKTLPETKSIFLVTNGQE
PDMLQKLQDENALPTQLYLSTNAADYESFMRINKPRYKDSWERWNTSLNMLSKLDTRTVL
RITLIRNYNDSDEIIPAFAKMVKRANTNFIELKSYMHIGRSTNRLEHSHMLEMDEVRYIA
SKLAEQSGIFSIMDESFVSRIVVLQNQIRFVDSTIAACAQTN
>A0A8D2JSP8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sciurus vulgaris|TrEMBL
MDAPPDAWDPASALPSLWTCRFYLYLGFAVGLGLWICVQVLSRQVKKSQERSIPKATQDL
MTNGYTTLPKKQIFVSGVKIFYGSQTGTAKGFATVLAKAVASLNLPVAVINLKDYDPDDH
LAEEVTSSSVCAFLVATYTDGRPTEGAEWFCKWLEEASSDFRFGRTYLKGMRYAVFGLGN
SAYPSHFNKVGKNVDKWLWMLGARRVLARGDGDCDVVRSKHGSIEADFRAWKTKFVCRLQ
ALQRGEKSYGGKCESKQHSSEDVEPAPHPGAASRHGDAKEEEPCESSSEEEFGTDDHGGL
SPVVDVEDLGKMMSLAKREKREEEQQEERSSFRNRGKKEGVEGRAMLTPALRDALTKQGY
QLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCVEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEKILEGAVQSHLDMMKQFRGVPGVKAERFEEGMKVKHCALSLVGEPI
MYPEINRFLQLLHQRRISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKDSLRKIDRPLF
KDFWHRFLDSLEALATKQQRTVYRLTLVKSWNVDELQAYAELVSLGNPDFIEVKGVTYCG
ESAASSLSMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLVAHRQFKIDGEWWTW
IDYGRFQELIQEYEDSGGLKTFSTKDYMAKTPPWAVFGARERGFDPRDTRYQRKSRSKDL
SGC
>A0A7C8NP97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MAEMYKSRSPDLIELWHTIRIPLIIAIGVLYITIRLRSILRARAPVLTTPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPVKPNPGAPPAVEGG
EEITQRNGKSIQVFIFYSSLTGSTAKYADKLSNDLFSEPLHIPKPTPPSVDNAEPEPVVE
KATFLPPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFP
IGMGDVKGDALANMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPSKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYANLVEKGLPAFVEIKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNGALQKRGLGYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTA
EEVAAELAAEAAEAESGCG
>A0A7C8KZE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces marneffei|TrEMBL
MADSSLVPGLLATWHSFRIPIIVSLAVFFLFVRFTSSKRSKSSLSSSPPPSPRLESAILK
EKPVAPIPEQKSVTALKPAPKPLASGPKRVVGNKDRRVGKNSQKSDGIGGPSYIKPVIFF
ASLTASTQTHAQWLLEQLRTAAQEKSPGNDNEWGLLPPELYDLAEVDFDDHFITAPKAPV
NSPNTRYVYCFLIPTYNIDTIIDTFIAHLDETHNDFRIDTAPLSSLAGYSVFGFGDKEGW
PTEEDGFCSQAKEIDRWMAKLTGKKRAYPLGMGDTKTDAINALKDWTSGLVEILLEVAQT
GGLGEGVAGSGDPFESDEESAAEDEDQPSSKKTQTVVDLEDINFGGSAKKGKGDPIPVDF
TTVSKVQTSQAALKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNGVKEGHYKKI
KMLKGIPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHNEQISSFLVCNAQHP
DQLATLDRVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILREKRHFQRTVFRLT
LVKGFNIDDEVKEYADLVEKGLPCFIEVKGVTYCGTSSSAGVGLTMKNVPFYEEVVAFVV
ALNDELERRGLGYGIGAEHAHSCCILLASDRFKVDGRWHTRINYDRFFELLEKEKTEGIS
FRPEDYMRETEEWALWGNGGFDPNDQRVRKVRNKKLKNDQTAEQNMTF
>A0A6A6G9D2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Elsinoe ampelina|TrEMBL
MELFTELLAIWHSHRIELLVLTGLVLAYFRIYHVRKHEDVASVADSKEKDTGAVFVRTGS
KDKIYELPLVRPKVIARQKSEGPKRVTGGRKSSPHKSNGIPKESEEYRVEPVIYYFSLGG
STTKLAEALFDQLSRFATQHVTILKPQMHNIVDVDFDNHFVSPSKASGVQQFYMILLPTY
NIDSELTTFIDSLTETHNDFRIDTAPLSGLAGYSVFGTGDKEGWPTEADGFCTQAKEVDK
WMARLTGKKRAYPVSTSDVKEAAATLSAWRKGIEEVMLSLSSKQGLGEGVTGSGDPVESD
DSDLGGDDSDSSRRKKRKRPSPTADLEDIRGPADLETDFTTIPSSKPKEMVPTISPTYTA
LTKQGYTIVGSHSGVKLCRWTKSALRGRGSCYKYSFYGIASHRCMESTPSLSCSNKCVFC
WRHGTNPVSTTWRWTVDPPDLVFAGIKEGHYKKIKMMRGVPGVRAERFSEALRIRHCALS
LVGEPIFYPHINALLGMLHSERISTFLVCNAQHPDQLAALSHVTQLYVSIDAATKEGLKK
IDRPLHRDYWERFLRCMDILREKRDMQRTVFRLTLVKGFNIEEEVGGYADLVERARPGFI
EVKGVTYCGTSTSAAAGLTMRNVPFYEEVCAFVEALDGELQRRGLGYGIAAEHAHSCCIL
MGERRRFEKEDGWHTLIDYERFFDCLESGREFGPEDYVGEKTPEWALYGNGGFDPRDVRV
DRKGRPKEVEAEKETGKVVEI
>A0A8D3CFW3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MLNFLLVVLLFLTPVSTSDIEVSQDEHSPGESYFLSVWHNRLYLYSAAALVFGIWFSLKM
ALKKKSFSEDVGPLVYKAVTNSDRSDRDTVVHVSGVRIFFGSQTGTAKGFANELSEEVKT
LGIPAEVTDMRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNG
SIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEEDLME
SSSDEDESGLQDEKKSGSVVDMEDLGNIINIAKKAKSKEEGGGGGQVVKLSKMNGVKKIE
DEGEKREMITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVK
PERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVT
QLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQA
YSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEH
EHSNCLLIAHTKFKVAGEWWTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPGWALFG
ACEQGFDPADMRFKRRNKAKDISGC
>T2M4Q0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hydra vulgaris|TrEMBL
MKNCEPEEVLLEETDSNSLCVFIISTYMGGSPPESATWFCTYLKEASDDFRVQKNLLKGL
KYTVFGLGNSLYEDHYNTVAISLDKWLHKLYANKVFPLGLGDENVSRKEKGTISDDFTTW
MKTLVLEYQKSQCFTVENKTIGEKKVEEEKKYESESEDESTAGSGGGGCKSTSGTSGIID
VEDIGKVINNQNQDEYDESFVGEKTAPVNREMVTPLLKKSLEKQGYKIIGSHSGVKICRW
TKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWAMDDPN
IIVEKAMENHYKMIKQFKGVPGVKLDRFQEAMDIQHCALSLVGEPIMYPEINKLINLLHG
KKISTFLVTNAQFPDAIKQLKPVTQLYVSVDAATKESLKRIDRPLFRDYWQRFLDSLSAL
SEKGQRTVYRLTLVKAFNTEEIESYAKLVSLGQPGFIEVKGVTYCGESKASSLTMENIPW
HEEVVSFVKTLAESLPDYELASEHEHSNCVLLCHKRFKINNKWHTWIDYAKYHELIKAYE
DSNGKKTFSDMDYLAPTPEWAVFGDDRKGFDPNESRWHRKKKKDISGC
>A0A086QWH8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii MAS|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGTKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSANVSKECHTSAKPQGSSAAASAVGEDSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKERGKAKTEGHSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A7L2JJX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cinclus mexicanus|TrEMBL
DVSMDTWSYFHTCLLSIWLHRFYVYSAVAFGISLWIVIQFTTTRTRRKKSHGNPSSLEGT
ADKLGNGCALSQSQEVHVAGVKVFYGSQTGTAKRFAKALAEAVISLNLPVEVINMGDYDP
EDGLVEETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAASDFRIGKSFLQGLRYAVFG
LGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRDEGDCNVAQSKHGSIEADFEAWKTKFLT
RLQALCKGEKKSCSGKCKKGKCKSSGKQSKESSDHEPRMSEHDNTEAEELFETSSEEEAG
GTDSVIDVEDLGSVMGHMKKAKVLLLEGVWNIHGVSHSGYHLVYFVCQFVQAKVSCLMNC
ALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKG
>A0A367IR74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus stolonifer|TrEMBL
LLYNFTNILSIGPEVPREGEKECGTGCCKDQPDQPSCQSAPVESSGCCQQGDNCCKTSQE
PLEIESIKILFSSLTGTAKTFAEEIQKKLQESKVVKVQEIKAMDITEYDNDNLLSETSVC
IFVLSTYNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGEEFNVASANI
DKWLGRLGATRIYPLGECDKNADQRAQFDLWSNDEMVDLEDMGKMASKIKAAKAKRAEEE
EDFENSKAKAKRAIGEVKSKEKTQAREMVSPMIHKNLTKQGYKVVGSHSGVKICRWTKSA
MRGRGFCYKHAFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKYILD
GAMENHYKMIKQMKGVPGVKAERFQEASTIRHCALSLVGEPIFYPHINEFVNLLHEKRIS
SFLVTNAQFPDKIADMVPITQLYVSVDAATKDSLKKIDRPLFRDFWERFLNCLEQLSLKG
QRTVYRMTLVKGHNTEEIDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMAN
>A0A061FCY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theobroma cacao|TrEMBL
MSPSSLSARLTLLALLSATTFYFLYKSRRRLKPLRQLPINSNPRKGKLFFITQTGTSKAL
AQRLLNLLSSNNIPFDLVDPQNYEPEDLPKESLILIIASTWEDGNPPQGSKFFVNWLAEI
STDFRAGNLLLSSCKFAVFGVGSRVYGETFNAVARNLGKRLRGLGATEMVAVGEGDVDGG
ALESVFKEWSEKVVRVLKGGLVVENENGIVYASDAESFESDDDDNGGGGGEEEIVDLEDI
AGKGPSRKKSVNVAETNGKMDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTA
IDLHTKMIKQMKGVPGVTQERLTEGLTPRHCALSLVGEPIMYPEINMLVDELHRRRISTF
LVTNAQFPDKIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALRDKQQR
TVYRLTLVKGWNTEDADAYSKLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKA
FSEALALKSEGEYEVACEHAHSCCVLLAKTDKFKVNGQWYTWIDYEKFHDLVSNSINLII
CSVSGL
>A0A7C4H6D8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MTHNAVAIHQRNDQVLDILHKQKYHIVGSHSAVKKCYWIHKSLTEKMFCYKAKFYGIESH
RCIQFSPAVLWCWNYCLHCWRYRPSSDHGFRSIEAVDDPRFIAEMVVKEHKRTVSGYKKY
PNVDRKMYEESLNPRHVAISLTGEPTLYPRLDELIEEFHRMNLTTFLVTRGIRPEILANL
SKEPTQLYVSLEAFDEDSYRYFNNPVYPNLWKRTLETLEILPSFSSPTVVRLTLIRSFNM
NLKAVSEWVKLLKIAEPTFIEVKAYMHIGTSILRLSRDDMPSHREVREIAIEIANGLGYN
IVSESVPSRVVLLSRLDKPVIRYGNPPISWYDKDLLDEYSGEYGILDDFI
>A0A2J8T1X6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pongo abelii|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGRNLQEKSVPKAAQD
LMTNGYVSLQEKDVFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEAAIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQRGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGKDHQSLNSIVDVEDLGKIMDHVKKEKREKEQREEKSGLFRNMGRNEDGEIRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWRRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVCELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A369T2M8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon NZ13-K|TrEMBL
MLSALVTTPSHVRRLMEKQGYKFILNHSALKPCYWFRKSIMEGRTCYKNKFFGIPTWRCI
QMSPTASFCNLQCSYCWRLNASDVPSRSRWVEVPEGTWDDPEEIVEESIRIQRMLIQGYK
GVKVFRRDWVMEAEEPKHAAISLTGEPMLYPRIGGLVEAFSKRGMTTFIVTNGTLPERIE
GMEKEPTQLYVTVPAPFERLYAEITRPLWPDAWSRLLRTLELLQSLSCPTVMRIPLIKGF
NMDDKTLEGFSKLVERYQPTYVEPKAYEWVGYSRRRLSKENMPWHHEVKEFALRLAALTG
YNVLDESEESGIVLLSRLERAIRFY
>L0P7P1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pneumocystis jirovecii (strain SE8)|TrEMBL
MNYGEKNDILCSKETKNDTDDQVLKYEKIKTLKRFIISPERRRKITSSLKYESMKAFENN
TQGMTDIVIDVYVTILYQTLMGSTEKYAKLLYDMIFPYFEKQVSLENIDFVEDLDDYFVS
PKNSQSHIFILVIPSYETDSPVDMLISMLKDTLHDFRLGAFPLRDLKGYAVLGLGDQENW
PQQKFCYQAKEIDRYLSKLGARRIVPICCGDVKGNIVNDIQVWANKVVNVIKNRTIPELI
SDISEESDNDAFEDNQDSVVDMEDIGMLMKVKKNDSEELTIKEMVAKDSPTYKALVKQGY
TIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMEITPSLACANKCVFCWRGHTN
PVGTSWRWKTDKPEDILAGVMAGHHDKIKQMKGIPGIQLQRLQEAMRIRHCALSLVGEPI
TCMFFTANPYINELIKMLHDRKISTFLVTNAQHPDALENIEQVTQLYVSIDASTKDSLKK
IDRPLFKDFWERFLSCLEILGRKQLRTVYRLTLVKQFNTQEIEEYANLVFIAKPCFIEVK
GVTYCGNTDSSPLTMQNVPFHEEVVNFSKALTQKISEIDNMPEYRIATEHVHSCCVLIAQ
KRFYINDKWYTHINYDRFFELVESKMPFSVMDYISETPSWAYFNSVHGGFNPEDTRWRRK
GAKPIDLKKDME
>A0A0I9YIY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella fujikuroi|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILIAIRTYFHINGKKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYVEDFCGKLDELSKLSGRQFLKPEIRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A5B0RGZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia graminis f. sp. tritici|TrEMBL
MFSLVESITSRFNLTNHTNADRPLNTQVLYSSLSSTTKKLANQLSTSLQSSSQHLHSTLE
SLDHLDLDQLIIQTPVDSTYQLAIFLLPSYNVESPVDSVLAQFRDALFDFRLSKNSLAGL
SFAVIGIGHSDYRDEFCKQAIELDEILEGLGARRLLPLQKIDVAVDPERDLDHYYHSIIQ
KTFHPALKSFSELPTIKSQEIKKYSAENEEEEEEEEEEEQDEVDNSDDEFVDYSNSKPLS
KAEKARQKSKRLLNKKINQGEKKTNGTQDIEDLGVGVPQIENLTSNSKDDAENQMIKKDM
ISPMTRKSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLA
CANKCTFCWRSHTNPVGTSWRWKTDDAKFVVEESLKEHDRLIKQLAGMPGVRPDRFTEAR
TPRHAALSLVGEPVMFPHIKKYISLLTEKRISTFLVTNAQFPDSLLDLPPVTQLYLSIDA
GTKESLKSIDRPLHRDFWERFLESIDIVRKKKIRTVFRLTLVKGENSDEIKEYAELIRRG
QPDFIEVKGVTYCGYPGSSNLTIKNSPWHNEVIKFVEDLCEEINDPRYRASSQNGDAQQA
PIAEYGLAAEHAHSCCVLAAHQKYYFDDQWHTWIDYDKFFELVESGQKEFEGLDYCDVTP
EFALFGSPQAGFSPEDQRWFRKKTLAKNSQLEDPLADQTAPSSVGLVVAPGPAQDV
>A0A2C6A599|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cordyceps sp. RAO-2017|TrEMBL
MHLFDWLSGLQSDTTADDVVQLWHAHRTPIIFCALVVLIFVRTILHKRDDKIELVALPQI
YQKRAALADCPPSVHTQPDDRTLAKANGPRRIKGGIARRPAQNAQHNPDLARPIKLVVFF
SSVTTKTDKIARDFLADCAKATEQLARDTNRAFLVPDLYDLSEIDFEDFFVSTPSGPDQA
RLFYLFLIPSYNIDTINDTLLQHLQETHHDFRIDTAPLVSLLGYAVFGFGDREGWPDEAD
GFCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDYSERFDEWAAGVRETIRHIARTGNLGD
GVRGSGDAVESDDEDRVDDVDEDADDEEPADEKQPTSRALDDVEDLGKMLRTTGDGANTE
QPKAAPLAVDFTTYGPSSGKPPQSRVPVVKEMVAKNSPTYAALTKQGYSIVGSHSGVKIC
RWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDP
PDMIFEGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPHINEFLALL
HAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLD
ILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTATSSNAGL
SMSNVPFYWEVCEFVKALEQRLAARGLRYGIAAEHAHSCCILLASERFRVDGRWHTHIDY
ARFFQLLEERGPDGEWTPEDYMGEPTPDWALWGNGGFDPRDQRVDRKGRKMENLVVRERP
PGEVW
>S2K0U2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor circinelloides f. circinelloides (strain 1006PhL)|TrEMBL
MSNFINSLLYGFTNILSVGPEQPREGQENEGGCSGSNGEGCCKDKPQETMATKAQSGCCQ
GDNAGDACCSSSAEPAVEATKEDGCCQSTPGKSSCACESASNEPVIIDNLKIIFSTLTGT
AKTMATEIEKKIEANQRVTVNKIEVMDVTEYDNDNLLQETAVCVFILSTYNVEGPLDWFS
NWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAANIDKWLGRLGATRIYPLGE
CDKNADQKGQFDVWSNGFVSELEDKHSLEFSPTNIAFQSDDEDDEASAEEEEQQPDIDID
GSGSGDEMVDLEDMGNMASKIKAAKAKRAEEEEDFENSKAKAKRLIGTDAGNKPKTAPQA
REMVSPMILKNLTKQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTP
SLACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQLKGVPGVKAERFQ
EAFTIRHCALSLVGEPIFYPHINEFVTKLHENNISSFLVTNAQFPDKIAEMVPVTQLYVS
VDAATKDSLKKIDRPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAEIDGYVELI
RRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCQKLVSKLDGDYEISAEHAHSC
SLLIAHKDFKVNGEWHTHIDYPKFFELVKSGKPFNSLDYMAKTPDWALHGHEAAGFDPNE
TRHYRKNRKTVVPPVNADINAV
>A9T8M7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Physcomitrium patens|TrEMBL
RGKIFFASESGTTKRLAERLLKKFNDKSLPVDLVDPASYEPEDLPKEKLVIVVASTWEDG
KAPKNAAFLAQWLEESSEDFRVGSGILRECRFCVFGVGSQAYGANFNAVARAFDAHLASL
GGLRMALRGEGDVDEGTVDQEFDDWSKALLEKLERADPRRLSHESAAEPATQGSDEDSDE
DSETFEDADESGNFSDGVVDLEDMGGQRGMSEPLEASQKRGVVRRQPPKKQPTPLAKVLK
DGPKEMVTPVLRASLEKQGYKILGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGKSWRWQMDDPVDIVNGALEQHTKMIKQMKGVPGVKPE
RLAEGMNPRHCALSLVGEPIMYPEINTLVNELHKRRISTFLVTNAQFPERITNLEPITQL
YVSVDAATKEKLKAIDRPLFSDFWERFIDSLKALEDKGQRTVYRLTLVKGWNTEEVKAYA
ELLDLGQPDFIEIKGVTYCGSTATSSLTMENVPWHEDVKAFAEAIAAERGGAEYELACEH
SHSCCVLLAKTSKFKVNGKWHTWIDYEKFQDLVASGKPFGSEDYMAETPSWSVYGAVEGG
FDPKETRVKKERRHGTADPGGCT
>A0A5A7QYZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Striga asiatica|TrEMBL
MDLSLTSEYDGRPARDGGGKLILEMNRLLRPGGYFIFSTKHNSIEAEEAFSKLTSSICWN
ILADKTDELSDVGVKIYQKPETNEIYELRRKRDPPLCKENENPDAAWYVQLKTCIHPIPE
AIEQRGTEWPAEWPKRLYTFPDWMSNDREKLIADSEHWKAIVNNSYLIGIGIDWSTIRNV
MDMKAIDGGFAAALSEQKIWVMNVVPVHAPDTLPIIFERGLIGVYHDWCESFSTYPRTYD
LLHADHLFSRLKNSLIAEKSAPTKKTQASRLSHFNVEDYHRLQACELWIMENWRPKKKRE
RDGFEFNVGVRRSAGEGWSDFTCLCDFERLRIDFVTLSRRIGDSTTQSRDFDNLVPANAG
LNFLLTLEINPLEIKNFPAMSPPPLPSTRLALLTLLSATATVYFLYKSRHRHRRLLARLR
GALSQPDRCVPIPSPPPNRGKLFFISQTGTAETLARRLHEWLAENGLPFDLVDPKDYEPE
DLCREGLVVFVASTWENGGAPENGAFLVNWLAESVDDFRVGALVLKDCKYAVFGVGSGSY
GETYNAVARGISVKLRKLGASELVESAEGDVDEGNVDEVFDGWCKKIIGVLKGDSLGENV
GHFGNNGVGGESAEEEGEEESEWSEDEYNDDEAAVVDLEDIAGKGPSRKSMAGDKANGKP
NGRVVNGEKEMVTPVIRANLEKQGYKVIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIES
HRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLVIVDTAIDLHTKMIKQMKGVP
GVKAELLSEGLSPRHCALSLVGEPIMYPEINSLVDELHRRRISTFLVTNAQFPEKIKMLK
PVTQLYVSVDAATKDSLKAIDRPLFSDFWERFVDSLEALKEKQQRTVYRLTLVKGWNTED
VDAYSSLFDIGSPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKEFSEALSRKSKGAYEV
ACEHVHSCCVLLAKVDKFRVDGQWYTWIDYDKFHNLVSAGEPFTSKDYMAPTPLWAVYGA
EEGGFDPKQSRFRKERRHKSTR
>A0A075B328|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rozella allomycis (strain CSF55)|TrEMBL
MTENNFEIKILYGTQSGTAKKYSEIFAEKAKEVADIVSVVNLADYDPEDLGTEKALCVFF
VSTYTEGSAPETAKFFFEWLSEATVDFRVDKDFLRDLKYAVFGLADSAYGDNFNKAGKTL
NLCLKKMQGKRVFPMGVGDASDEQEETFNKWTNKIIQHLKSKMAENVEYESTDEETVEKE
VMDLEELGSLASKLKVKGDSSEVKEMVTPIVRESLQKQGYKIIGSHSGVKICRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWKMDNAEFVLNGA
IENHQKMIKQMKGVPGVGQERMDEAFEIKHCALSLVGEPIMYPEINQFVTLLHQKRISSF
LVTNAQFPELITSLVPVTQLYVSVDAATKESLKKIDRPLFKDFWERFLASLSELSKKGQR
TVYRLTLVKDFNVNELDNYIELVKRGQPDFIEIKGVTFCGYTGSNPLTMSNVPYHKEVVE
FCKLFVSHLPDYELSCEHEHSCSILIAHKKFKIDNEWYTWIDYEKFHEFANSESSFTSLD
YMTKTPSWALYGSNERGFDPNETRFYRKKASKDEPIDHGC
>A0A484DKR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perca flavescens|TrEMBL
MLISQKYGCTQHQLQRTVYFNTPIAKMLSFSVIIGLCISRVSTLDTKVSQNAHSPSESYL
MSIWQNRLYLYSAAALVFGIWFSLKLVLKKKSFSKDVGPWVYKAVKSNDSPDRDPLVHVS
GVKMFYGSQTGTAKGFAEELSEEVKTLGIPAEVIDIKDYDPDDQLADECTNKSVCVFLVA
TYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDK
WLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFVAWKVRFLKRLQALAKGEKKGCSGNCKN
GGSCKNQRKDGQEEEEEGEKAALQNNSSEEDLIESSSDEEDSGLQDEKNSGSVVDMEDLG
KIMNSVKKAKSKEEGQGDGQMVKLSKLNGVKKIEDDGERREMITPALRGALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWRWKMDPAEKILQDALEKHQSMIRQFRGVPGVKPERYDEGLAVKHCALSLVGEPIMYPE
INTFIRLLHSHRISSFLVTNAQFPKEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFW
PRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVTYCGESSA
SSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLMAHTKFKVDGEWWTWIDYE
RFQELVQAHDESGGQQGFSALDYMAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A3N6N2R9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrarchaeobius chitinivorans|TrEMBL
MSDSADSGVDARASGREDAAETDDTDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGK
CYKNIYYGIESHRCIQMTPVVRCNERCVFCWRDHNGHAYEMDDVEWDDPEAVVDASIELQ
TKLLSGFGGNDEVPREVFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSN
GTRPEVLRECDPTQLYVSVDAPERHTFDRVVKAMEDDAWERLLETMDVLAEKDDTRTVLR
TTLVDGENMHHPDWYAGFYRQADPDFVELKAYMHVGHSRGRLDRSSMPDHDDVVAFAEEV
MAYMPEFTECKDVPASRVALLSKTSDTWVPKLRKDSEFWERDPVTGD
>V5I3L4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Byssochlamys spectabilis (strain No. 5 / NBRC 109023)|TrEMBL
MTSSPAGLAGVVADLLESWHSYRLAVLVAILVVGTVTYIYRTACRRSKTSLSLSTPPSPL
VPSEKNPWTEDTRVAGPLSDSEVSKPPLRDDLRRSKPTSGPKVVQGKKQVKARGAQRSPE
QLESPLFIQPVIFFSSLTGTTERFAHTVLENFRSAAQAYSRNDHGRGLLPPEMHDLSYID
FDDHFTSAPKPPPNSPNTQYLYCLLIPTYNIDTIINTFLGHLEETHHDFRIDTAPLASLA
GYSVFGFGDREGWPTEEDGFCSQAKELDRWMAKLTGGKRAYPLGLGDITSDASSSLTDWS
SGVLEILYDILEKGGLGDGVPGSGDAFESDEEDVENTPDEGKTRKPRKNTTSGSVLDLED
IKFSVDSQSPSAGSSPLPVDFTTFGKSSNPVTQSAPKEMVPETSPTYAALTKQGYTIVGS
HSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWKVDPPELIFKGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHI
NEFLSMLHGEQISSFLVCNAQHPDQLAILDRVTQLYVSIDASNRESLRKIDRPLHRDFWE
RFQRCLDILREKRHVQRTVFRLTLVKGFNVDDEIIGYANLVEKGLPCFVEIKGVTYCGTS
SSAGAGLTMKNVPFYEEVAEFVVALNKELARRGLKYGIAAEHAHSCCVLLASERFFIDGK
WHTRINYDRFFELLEKEKREGTSFRPEDYTRETEEWALWGNGGFDPNDERVYRKGRNKTA
LPPSTS
>Q6FV09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)|TrEMBL
MDSTELTIGGLLVVGSAIFLTFFSGRITVLLVAVVGFCIFVNERHNHASSNTGASEIAAT
LSEKTVEEVLPLPKKKKCCGGGVGGKCCSETKKEGDHSDGGSCCSSKKKLVEPLLQKLKE
EKPASATEEPSYPISVDFTEAFKSTSKKSKKVPKIIVGVNKKKESEEDIVKSALTVSNEK
LLSSQIYVFYSSLQGAAERVARTVYEDLKNVKDLNNEPILMNLDELNDIDEYFVDVPVDN
ALYILVVPSYDTDCPLDYFLQTLEENYHDHRVDRLPLKKLMGYAVLGIGDKESWPDKFCY
QAINVDHWIAKLGGRRIFPVGEVCMKTDGMQGVDKWTNLLADTLEDDEPIIYQYDNDAES
DYEEDEEQIDFDSDTDVQDVEDIGGKQQSKGDYGMEVKQMVAKNSPTYNNLTKQGYRIIG
SHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCWRHGTNPVSK
NWRWDVDEPEYILENALQNHYSMIKQLRGVPGVIAERFADAFKVRHCALSLVGEPILYPY
INRFVELLHQNDITSFLVCNAQHPEPLRNIGKVTQLYVSIDAPTKQELKKVDRPLYKDFW
ERMLECLDILREVQYHQRTVFRLTLVKGFNMGDITSYADLVARGLPCFIEVKGATFSGSS
DGNGNPLTMQNIPFYEECVNFVKEFTKELQRRGLGYEVAAEHAHSNCILIANTKFKVNGE
WYTHIDFDKFFSLLKDTERKEQFTYMDYMAKTPEWALFGNGGFAPGNVREIRKEKKKKNR
EEREKALKEAQAALEVQQDA
>A0A0V1JI73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKRSVNWGRFRLLFRVHQRDFLAGGVVEIQRLYFKNWIAEHIFISFAYKLTTIISFLP
FGIGAIFVENIIIRETNFRQSPFQGGIFGRGILSRYCHCGQLNWISIFQIFFTIINNCII
GHAVFCGNVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSK
FSSVHDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIKE
MLTPTLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSL
ACANKCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEES
STVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVD
AASKESLKEIDRPLFRDFWQRLMNSIDILRDKKQRTVYRLTLVNQYNMNEVSQYASLIKR
GQPDFVEVKGVTYCGDSKNSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVL
IAKLNVTIFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGF
DPEDQRWYRKSKDS
>A0A2K5NXP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cercocebus atys|TrEMBL
LDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKTQGFATVLAEAVMSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGK
SYLKGMRYAVFGLGNSAYASYFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIE
ADFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDT
EEEEPFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQGENLQELRLRQETHLNWESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKI
DRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFIEVKG
VTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKFKIGG
EWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQRKN
KSKAISGC
>A0A086TEN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acremonium chrysogenum (strain ATCC 11550 / CBS 779.69 / DSM 880 / IAM 14645 / JCM 23072 / IMI 49137)|TrEMBL
MDSGLRISSPWMGYKDDLVEIWHANRSPILLAVLAALVVVRVYLHLKEPKGELVALPKVY
SKPVADSKSAVVPLDEKPKTSGPRRIKGGLVKKPSRTKEPEPSQSNPIKTLVFFSSVTTK
TQKIAEDYVKSLASTVDRMTQKTGRQFLQPELRDLTEIDFDDYFISVPKLDGGADLFYLF
LIPSYNIDTINDTFLQHLDETHHDFRIDTAPLSPLLGYSVFGFGDKEGWPNEAEGFCFQA
KEMDKWMAKLTARKRAYPVGMGDMRSDHAERFEEWAAGVADVIQHVAKTGNLGEGLPGSG
DPMESDAEDIAEDDGEVVFDDEETGSRPLDDVEDLGKMVRSSGDKSQKPKSKAPLAVDFT
TQGPSSKKAPAAPKEMVARNSPTYAALTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKY
SLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIFNGVKENHYKKI
KMMRGMPGVRAERFSEALRIRHCALSLVGEPIFYPYINEFLELLHGERVSSFLVCNAQHP
EQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFERCLDIIREKRFRHRTVYRLT
LVKGFNVEEEAEGYAQLVERGLPCFVEVKGVTYCGTATSSNAGLTMGNVPFYWEVCDFVR
ALEARLKDKGLKYGIAAEHAHSCCILLASERFRVDGKWHTHIDYDRFFELLEERGPEGDW
TPEDYMGPPTPEWALWGNGGFDPRDDRVDRKGKKIAPVVVRERPADAEYY
>A0A8B7UHX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Castor canadensis|TrEMBL
MGPPLDVWGLSPSLFSWWTNRFYIYSGLAFALSLWICLQIIFKKQAKNSQENSTPKATED
LLTNGYITLQKKQIFVSGVKIFYGSQTGTAKVTSKSVCAFLVATYTDGRPTDSAEWFCKW
LEEAASDFRFGKTYLKGMRYAVFGLGNSAYSNHFNKVRWQNVDKWLGXVGAHRVLTRGEG
DGDVVKSKHGSIEADFRVGRPSSLQEEEPCGSTSEEELGGDNSERPSSVVDVEDLGKIMN
HMKKEKREEEHLEEETSLFRGTWKNEDGEGRAMITPALREALTKQGYQLIGSHSGVKLCR
WTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQP
EMILKEAIKHHQNMIRQFKGVPGVRAERLEEGMEVKHCALSLVGEPIMYPEINRFLKLLH
QCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLRKIDRPLFRDFWRRFLDSLKA
LAAKQQRTVYRLTLVKSWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLTMANVP
WHEEVVHFVGELVDLIPDYEIACEHEHSNCLLIAHRKFKIDGEWWTWIDYDRFQALIQRY
EDSGGAETFSAQDYMAKTPPWAVFGANERGFDPKDTRHQRKHKSRDISGC
>A0A5F5XJH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Felis catus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDESVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKELQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKGVTYCGESSASSLTMANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLI
AHTRFKIDGEWWTWIDYNRFQELVQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDP
KDTRYQRKNKSKDISGC
>A0A086TJW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Podila verticillata NRRL 6337|TrEMBL
MTSSSPNLHLWKEYRIPLVCMAVGIATLSILLSNKNNIAPKDDKEDSKGNLDTSAPVETS
EDKPRTHQGLKKADFKKLPKVIRKKPKQKKADDEPGCCGGKNKAEGDNSTGCCGGKNKPS
NDNKAPHCACSTTTSNATPITVIDPLALPELVEPMKIFYSTITGTAKLFAQQLYDSAINA
GLPEPKIIDIVDYDTEDFLTETGLCVFILSTYNVEGPNDWFLKWLEDTRFDWRVEKGALS
KLRFSVFGLGDSAYTEEFCNGPRSADKWLGQMGAQRVWPFGEGDKNGDQGGAYKQWNDAM
LASLLDPTQSHVHEAYFSSDDEDGKSASENDDDEGDVDEDEIKKTKEEKLGLPTIDGDVS
EGEMVDLEDMGNVAIKIKQAKEDKALDEEAYANQKVRAKRSVGETKDGKAIKPREVREMV
SPLLHKSLTKQGYKIIGTHSGVKICRWTKAALRGRGFCYKHSFYGIQSHLCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKVDDPEFILEGALENHYGMLKQLKGVPGVRAERFVEATQ
VKHCALSLVGEPIFYPHINEFVKLLHKKRISSFLVTNAQFPDAIASMDPVTQLYVSVDAS
TKESLKKIDRPLFRDFWERFLDSLDALGKKGQRTVYRLTLVKDFNTDEIANYVELIRRGQ
PDFIEIKGVTYCGYGGASGLTMANVPYHAEVVRFVELIQEQLGAGYEIAAEHAHSCSILV
ASTKFKKGDTWYTHIDYDKFFELVESGQKFTSLDYMAETPSWAYFGAPEGGFDPEETRYF
RKTKEQRKAERERREGEDDEE
>A0A821X6A1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood1|TrEMBL
MTVDLYIFAAGTALTGLVFYYLAGAEWSLWHLFTIPLYTFIFIVFLSLSILKRFKTQLST
KIISQDKNGITIVFGSVKGNSRTFAQLTYDKLLNELNRQVILQDLNDITDPEEFLQIQVK
NQRILLIFISTYEDGISPPSAKWFLRYLQEAATDFRVSKNELEKLTYTIFGCGNSLYNDN
FNKVAKELDRCLLELSAKQFIPSEYADENTVKSIYGGLEGHYSKWLSQLISNLQSSKVDK
CDCSNDKSINCCQSLTNNNHSNENVEQLRIESDDDDEDGGGCKNGNDDIMDLEDMGDYME
THSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENHYKMINTF
KGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHSKKISSFLVTNAQFPNEM
KTLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLDSLRALKDKGQRTVYRLTLVKGY
NTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASHLTMANVPWHEEVVTFVKLLCDRLPQ
YDVACEHEHSNCLLLANKKFCIDGKWYTWIDYERFHELVTRHKVTSGAETFTSVDYMAIT
PDWAVVGSNERGFDPTDTRWYRKATAKKNLSGC
>A0A851VK57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Copsychus sechellarum|TrEMBL
DVSMDTWSYFHTCLVSVWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPGTADKLGN
GCVPPQAQEVHVAGVKVFYGSQTGTAKRFAKALAEAIASLNLPVEVINMGDYDPEDGLSE
ETSSRNICVFLVATYTDGQPPESVAWFCKWLEEAANDFRIGKSFLQGLRYAVFGLGNSAY
VDHYNTVGRRMDRWLWMLSASRIMTWAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQALC
KGEKKPCSGKCKKGKCKSLGKQSKESSDNEHRTSEHENTEAEELFETSSEEEAGGTDSVI
DVEDLGNIMGHMKKAKVLLLEEVWNGQVLTQLLMNCALFSGYKLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEVILQ
EAIEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINRFVRLLHQHGIS
TFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQ
QRTVYRLTLVKAWNVDELKAYADLISIGKPDFIEVKGVTYCGESSASSLTMANVPWHEEV
VSFVQELAQLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWIDYGRFQELVREHEQSGG
SRTFTAAEYTARTPAWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A218PBW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. P6|TrEMBL
MKLTFKSNPNMPEEIAELFRKQHYALVGRHSSVKLCHWLKESIKHNRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMESFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GIDMKKFEEAWNPKHAAISLSGEPMLYPYMGNLVEEFHRRGFTTFIVTNGTVPERLEEMM
REDKLPTQLYLSLTAPDLQTYNSVNVPMVPDGWERIKETLRLMKDVEARTVIRLTLVKGE
NMRNPEGYARLIKIASPMFVEAKAYMFVGYSRSRLTINNMPSHEEIRTFAEELVRHLPGY
HIEDEYEASRVVLIMRDDVHSGSGEGGRFIRH
>A0A2G9MJY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_33_12|TrEMBL
MSPELKALLEKQHYCFSGEHSAVKICTWTKKSLLDENVCYKEKFYGIRAHLCCQMTPSVG
FCTNQCIHCWREMEYTAGVKMNGILDEPEEIIKKSILCQRKLLNGFFGNEKANRKKLNQA
QEPMHFAISLTGEPTIYPKLSELISELHKLGKTTFLVTNGQFPDIIKSLKELPTQLYVSV
SATNEQDFKKFNKSCFKDGWKRLNKTLELMPELKTRTVIRITLIKGINMKDEKAYAGLIK
KAGPMFVELKAYMFVGSSRKRLLESNMPLHEEVKEFAEKVAELSGYKIIDEKKESRVVLL
AKKDYKDRIMRFD
>A0A4D6HNU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum bangense|TrEMBL
MSNSAETGVDTGSDAEQNEGDGDGGAMQVSSPDYHSENHTAAQTCGWTANALRGEGKCYK
NIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASLKLQKRL
LSGFGGNEEVPREVFDQAMEPRHVAISLDGEPSLYPYLPELIEAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMDVLADKDETRTVLRTTL
VKGENMHHPDWYAGFFQQADPDFIEMKAYMHVGHSQGRLDRSAMPDHEEVVEFTEQVQEY
MPEFTECKGVPASRVALLSKTKDTWVPKLKKDSEFWARDSVTGN
>A0A5F8GIC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monodelphis domestica|TrEMBL
MDASLDVWDHFSMPLMSLWVNRFYLYLGLAFGISLCICVQVAIKKLGDRSTKESSLQKAP
LTPAANGPISRQKKEEVFVSGVKIFYGTQTGTAKGLATRLAKAVKALGFPAVVVNLKEYD
PDDRLGEEVTSKHLCVFLVATYTDGQPPESAEWFCRWLEEASNDFRFGKTYLKGMRYAVF
GLGNSLYDGNFNKVGKNIDRWLWMLSARRVMTCGEGDCNVVKSRHGSLEADFAAWQAHFL
SRLQDLSRSDHSKKKAACRHRQGHCKKGECKSKKKEGKNAGPEGSRQEAPEEEEQFETTS
EEESGPEEGRSRSPVVDVEDLGKMMDSMKKAKKEREQQDMEQDMSRSPGKNEAREKREMI
TPALREALSKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPDMILQQAIDNHQNMINQFKGVPGVKAERLEEGLQ
VKHCALSLVGEPIMYPEINGFLKLLHQHRISSFLVTNAQFPTEIRNLEPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVEELRAYAELVSLGE
PDFIEVKATSSGCPLVEFYRHMNGVTVSCSSELILPDHCDALDGHEDDLKHAAMLTREAD
GRGSQDCRFLVCC
>A0A8H5N5Z7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium mexicanum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKI
YDEPAEPKVVVEEKTPTIELVEEKKNVRSQGPRRIKGGIARKPSKSKEEEKDTTRPVAPL
VFFSSITTKTAKIAEAYIEDFSGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVREVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSSRDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
EHISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
YNVPFYWEVCDFVRALEKRLNEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A420ID67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Golovinomyces cichoracearum|TrEMBL
MNSAGWNFKNLWSQETKTNRGQHSNSVDPVELWHIHRFSILLIILTIFVSLKLLFYFKAT
RENHPSTASNPKIISVEDSKKSSEKDQTSVQGRVPKRILGGLKKSRVSPTTENVSNQKIS
VLTFYSSVTGTTKKIAQDFTESLARSSEKLDNFGRNIFLKPELIDLAQIVFEDYFLNFGP
SNPNVRHFYLFLLPTYNIETIVDSFLEHLRETHNDFRIETAPLSPILGYSVFGFGDQDGW
PTEKDGFCSQAIEVDKWMARLTGGKRAFPLGMGDSKIDATENLEKWKEGIEDVLRHIAST
GSLGEGVIGSGDAEESDLEETDDDQGSNRKLKQSHRTKKRIEKKDTQNDLEDIGSTVNNK
SNDNSPQEINFTHYGSKSPPIIKEMVPKGSPTHKALTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELIFNG
VKAGHYQKIKMMRGVPGVRSERFSEAMRIRHCALSLVGEPIFYPFINEFLAMLHAEHISS
FLVCNAQHPDQLASLKPVTQLYVSIDASNRESLRKIDRPLHHDFWERFNRCLDILRQRRF
EQRTVFRLTLVKGFNIEDEIVGYADLIEKSLPCFVEIKGVTYCGTSSAAGAGLTMQNVPF
YDEICTFVESLDKELNRRGLDYGIAAEHAHSCCVLIASKRFQKHGKWHTRIDYDNFFRCL
ESGEKFRPEDYMGLETPEWATWGNGGFDPRDERVFRKGKNKVPLSLIEPKLGALSIEQ
>D2RFH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus profundus (strain DSM 5631 / JCM 9629 / NBRC 100127 / Av18)|TrEMBL
MIPKKLLKDLKGYAIVGRHSAVKPCFWLKKSLKDEGVCYKQKFYGIQSHRCLQMTPALIC
NQHCVHCWRPLELLRDVEGWDSPEFIAEESIKAHRKQLSGFWGNPDVNRRKLEEAQNPNQ
FAVSLIGEPTLYPYLPELVDIYKKWGSVFVVSNGTNPEMIEKIEPTQLYVSLTAWDSESH
IKLNRPIKNFWENILKSLKILANKDCRTVLRITVIKGYNDFPEKFAPLVNLAQPDFIEVK
AYMYLGYSRLRLPREAMPEHSDVKTFAEEISKLTGYQIKNESVVSRVVLLER
>A0A6Q2XG03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
MFLKHLSIFTLPQTIALETKAKMLQGSTLLLLDFITDILCADIDGKKTVRSTLESYILLV
WQNRLYLYTAAAVFVGIWFSMKIALKKKILTTPVNPWLYKSVKQNVYSVENVNVVHVSEV
KIFYGSQTGTAKGFANELEEEVKTLGIAAKVIDMKDYDPDDRLADECSTKSICVFLLATY
TDGQPTENAKWFCKWLEEASTDFRYGNNYLKGLRYAVFGLGNSVYDSHFNTVSKNVDKWL
WKLSGVRVLSRGDGDCNVVKSRHGSLHSDFLVWKTKFLSRLQTMVAGPKACRGKCKTGGS
CNNRKKPQKTDDEQAAPEQLSSEEELVESSSEEEAAGTGPDEQHPGSVIDVEDLGNMMNG
MRKAKRRVEGQVDEQMKLPRLNRQKKAEEEEERREMITPALRVALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPPEKILLEAVENHQNMIRQFRGVPGVRLERYQEGLKVKHCALSLVGEPIMYPEINAFLC
LLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWTRFLDS
LKALGEKRQRTVYRLTLVKAWNVDELKSYSELISLGQPDFIEVKFKVDGEWWTWIDYERF
QELVQAYEESGGSQTFSAMDYMAKTPMWALFGASERGFDPTDTRYQRRHKTKDISGC
>A0A4D8S093|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metallosphaera prunae|TrEMBL
MAVKGSFRIDTLSKIREEMEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMTPVSMWCWFRCIHCWRLEPEDVGLDWDETKMPYMDDPEYIVERSIEEHKRSVSGY
LGREGVENNKALEAMKPSHVAISLTGEPTLYERIGELIREYHKRGITTFLVTSGVRPDVL
ASLEEEPSQLFVSLQAPNEEKHRLINRPVVANSWNLVMKTLEILPSFSSPTVIRMTMMKE
VNMSDDDAREFAKLMRIAMPTYIEVKAYMHVGPSTYRLTKDAMPRHSEVRFFAEKLAELT
GYKIISEHAPSRIVLLSTIDRPMQIGNAWTEKWDWRTQDTQDDVNGEYREAEMGCTEEGD
GPKP
>D1YWJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)|TrEMBL
MSLVELLKKQGYHIIGEHSAIKPCLWLGRSLKSQGACYKSHFYGIQSHLCMQMTPCIACN
QRCLHCWRPVEEPYAVRSWDRPETIIEGCLKEQKRFISGYGGIPETDKKKWKDAFEPRHA
AISLVGEPTLYPHLKELVALLGERGMSTFIVTNGTRPDVLEKVTPSQLYMSLDAPDRETY
LKACNPVADLWDKVNDSLEVLGQRDSRRALRLTLVKGVNMKDPEGYAALIKKAAPDYVEV
KAYMHLGYSRNRLPREAMPKHDEVLEFARKVADASGYRLASDVELSRVALVSKDGAVKAL
M
>K6T6F5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. Maddingley MBC34|TrEMBL
MPLSDQAIQSLEKKGYRFVGSQRHAAAKVCHWTKKSIMDDGVCYKEKFYGIKSHRCLQMS
PSIPFCHHKCLFCWRDVAITNTTWEEDFDDPGEIIDECINAQRKLLVGFFGNPGANQKKI
SEAQDPTNAAISLAGEPLLYPSINQLLEEYKKRHFTTFLVSNGLSPDKLGSLDPEPTQLY
LSLDAPNSSVYKKLCDPQIKDGWEKLNHSLDLLSSFNCRTVIRMTSVAGYNMTHPEEYAR
IIERSDPDFVEIKAYMYVGSSRDRLKFDNMPRSKELESFAQEIASLCGRKIVDQSSESRV
VLLA
>A0A3M6Y0C9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MPIAPGECTAAHVATNIHPPPMMDMEKILQLPEELLFLWHAHRAEVLLSAGLLFALLRLA
VHWRTRKSKEVLTPPVLTPVDEKPLAVPSAKETLADADHYEAPTPKPAVQRPKPGPKRVT
GTKKSKSAASQEAQVIEKIQPIIFYYTLGGSTKVYAESVAQDLTTSSPSPILEPQLHDLA
DTEYDDFFLSIPKAEKTAHFYLLLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSKLAG
YSVFGLGDKHEWPSEAEGFCTQAVDADKWMARLTGRKRGFPLGFGDVSKKDEADVMLKEW
TEGVSSIMKDLAEGKGLGEGVPGSGEPIESADEASEDEDETPAPRKSKRKPAKRSKTDDL
EDLKAPIPVDFTTSKPTSTTQPPPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPV
FQGMKEGHYKKIKMMRGVPGVRAERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRER
ISSFLVCNAQHPDQLEALGPVTQLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGR
KRFTHRTVFRLTLVKGFNIEEEAEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQN
VPFYQEVTAFVLALEKALANRGLDYGIGAEHAHSCCILLADRERFYRIPEAEKDNPAAEK
KWHTLIDYPRFFDCLESGKPFSPEDYVGPPTPEWALWGNGGFDPRDERVDRKGRPKEQAK
VQEVQ
>A0A4S2N469|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ascodesmis nigricans|TrEMBL
MASPNPPSSWTTLVLDAWHEHRIAIFVSALATVALFRLYSSLRRLLYQETKSIDSLSAKP
KLDAPFLSAESEKNPAAKTAVSRLDPSEVDIERISRSVKQSAPNPSAGKAKAGPKRIAGK
KPQISPSRRPGKQNGRVATDIHEGDFDVQVLIFYSSLTGSTAQYAKDLKESLFSATEGPY
PKLSIETPSNGLPAAPISRNFLPAQLYNLEEIELDDYFISPPKAEEDVKGVKYIYLVVTP
SYETDSPVAPFLEHLQETHHDFRIDTAPLRSLAGFSVFGFGDSSEWPSSEGKFCQDAINV
DKWLGKLTGGRSGSRRLFPLGMGDMNPSGEGPGADESFKEWRIHLEEAMREYAETGSLGG
SPESRTAVESGDEDSELEDEDAEAEDVVDLEDISGMIPKKTSRKDDSTGTVKPAPLPIDF
TTPAGKLALAAGEGQAEHRKEMVPKDGVTYSALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKFSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDAPDVIFRGVVE
GHYRKIKMLKGVPGVRADRFAEAFRIRHCALSLVGEPIFYPYINEFLALLHGSKISSFLV
CNAQHPAQLRALGPVTQLYVSIDASNRDSLKRIDRPLHRDFWERFQECMDIIREKRDVQR
TVFRLTLVKGFNVEDEVQGYADLVERALPNFVEVKGVTYCGTSTAADAGLTMGNVPFYEE
VADFVVRLDKELTRRGLEYGIAAEHAHSCCILIASKRFHVNGKWHTLIDYEKFFKLLEEG
REFSPVEYIGEANPEWALFGNGGFNPEDERVYRKGKGPKAVAAGGACGAGEEESGGCG
>A0A0M0BPP8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|miscellaneous Crenarchaeota group-1 archaeon SG8-32-1|TrEMBL
MKSSVPNEIILMLHKQKYHLVGNHSAVKRCRWLYNSIIQDRTCYKQKFYGIKSHKCLQMT
PSLFQCTLGCVFCWRAQSGDHNMHWDETQMPKWDDPETIIEGCIREQKRILTGYKATPNA
NQKKRLEALTPKHAAISLTGEPTIYPHLDGLIKNFHKRGLTTFLVSNGTDPEALSKLKEE
PTQLYISVSAFNKKIFSKICRPHVNNAWKKLNETLELLPSFNCPTVIRLTLAKSLNLEYP
ECFVELIRKANPTYIEPKAYMHVGFSRLRMEYSNMPTHTEIKEFANQITSKLNYNILDEA
TESRVVLLSRLEKAIKLA
>L9ZMW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema altunense JCM 12890|TrEMBL
MSDSANPGADGASGDATAEGDGGGPAQVSSPEYHSENHTAAQTCGWTANALRGEGKCYKN
IFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVAWDDPEAVVDASIDLQKKLL
SGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRP
EMLRDCDPTQLYVSVDAPERHTFDRVVGAMEDDAWENLLETMHVLAEKDDTRTVLRTTLV
EGENMHNPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPDHEEVVAFAEDVREHM
PEFDEVMGVPASRVALVSKTNDTWVPKLQKGSEFWERDPVTGD
>A0A1Q2ZXR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces rouxii|TrEMBL
MRSNPVTAVATALCTGAYLWFGGRISVALAILVSYGIWHEESHKVVEEKPQLPLDGAEEK
TKKKHTCCGGKGGSGCCSSKNGDGGSAHACRCGSKKNKAVEEQKKDTDSYPVAVDFTQAF
KPEKKKKSRQPKVFSKSMPAKKQNEAPKQDNLVKSAMTVSNETLLNSQIYIFYCTLQGAA
ERCANKVMAKLCTMKELKHRPILLNLDDLSDIDDYFVNVPCDNALYLMVLPSYDTDCPLD
FFLQTLEENFHDFRVDRFPLKKLVGYSILGIGDSESWPERFCYQAKKADHWIARLGGRRV
FPVGEVCMKYDGEKKIEDWTNLFAETLKDDEPMLYEYDESVEEENENADGGEEMVDLEDI
GNADGNNSTEIKQMVAKNSPTYKTLTKQGYSIVGSHSGVKICRWTKSDLRGRGSCYKHSL
FNIVSSRCMELTPSLACSSKCVFCWRHGSNPVSKNWRWEVDDPEYILENALTSHYSKIKQ
MRGVPGVKAERFAKAFQVRHCALSLVGEPIMYPYISKFISLLHAKGISSFLVCNAQHPEA
LAKICKVTQLYVSIDASTKSELKKIDRPLYKDFWERLMQCLDILSTTQSHQRTVFRLTLV
KGFNMAEVMSYADLVQRGKPCFIEIKGATFAGSSDGNGNPLTMQNIPFYEEIKAFVRNFA
AELQRRGLGYDISAEHAHSNCILIANTKFKIDGEWYTHIDFDRYFELLNSGKDFQPLDYI
AKTPEWALFGNGGFVPGDTRFYRKGKKKGPEQAEPTPKQTVETAGSIEIA
>A0A557SSR9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosocosmicus arcticus|TrEMBL
MSCSGEIYSHSNTDTDLIQITPAVKQKLKKAKYGVFNHSAVELCHWTKKSFSDGGSCYKH
KFYGISTHRCMEMTPTALNCENRCIYCWRPTEFYDTMEMPTHLVDDPEIIVQNLLEERRK
LIVGYYGKTDVNVSKLDESLFPEHYAVSLSGEPTMYPKLPELIKYLSKLKATKSVFLVTN
GQEPEMLYRLANENALPTQIYLSTNASNKNMFYKINGPKHRNAWERWLQSLDFISQVDTR
TVLRFTLIRSFNDNPTFFKDFAKLVEMGNPHFIELKSYMHIGMSTNRLEESNMLEMDEVR
SFAGGLKTHLDDYILMDESIVSRIVVLQNKARFISRWIESYP
>A0A8H5YX06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium globosum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVALKKV
YEEPAKPKVAVEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCAKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKSH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EAGGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDEEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVGGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A2R6RMW3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Actinidia chinensis var. chinensis|TrEMBL
MPAAAARLTVLAVLSAATVYCFYKSRRLRLLTKLSHSNLNPNHTLSPPKGKLFFVSQTGT
SKTLARRLFDLLTTNGLAFDLVDPKDYEPEDLHKETLVLIVASTWDDGKPPPNGGFLADW
LAESADDFRVGSLLLSKCRFAVFGVGSRTYGDTFNAVAKEFSKRMRSLGAAEVLPMWEGD
VDGGDLDVLFDGWSEKLIGVLKGGALENGDKFGYEGGVESDFEVISNSDDEDKDENGEDS
GIVDVEDIAGKAPSRKSMTLVRPNGKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVKLCR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
LDIVNSAIDLHTKMIRQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEINSLVDELH
RRRISTFLVTNAQFPEKIKLLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFVDSLKA
LKEKQQRTVYRLTLVKGWNTEDIDAYSSLFSVGNPDFIEIKGVTYCGSSATSKLTMENVP
WHSDVKAFSEALARKSEGQYEVACEHVHSCCVLLAKVDKFKVNGQWFTWIDYEKFHDLVA
TGRTFDSKDYMAATPSWAVYGAEEGGFDPGQSRYRKERHHKSSH
>A0A0D2IWI3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fonsecaea multimorphosa CBS 102226|TrEMBL
MDLAEAGAAPVILADWLDRILTSWHENRVVLSTLLGLCVLAVIVQRRHAYKIAQRGSPTL
EKAEWLAQNDDAHVQVEKGERNEFPARNTPSLTSGQARKPRTAAAAVRVVTGRKPASSRG
GQAALQRRREPSHIKPLIFFSSLTGTTERLSKQVAAELEQISAAQHAILRPQVYDLSYVD
LDDYFISGPKTPEPNADVLYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLA
GYTIFGIGDKEGWPSEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSNLDKALQDWT
GGVCSVLKEVSKTGALGEGVPGSGEPVESGDEDEPEQGDEEVEFPDSGRNKRRKLANTTD
LEDVGGKANSYAAPIAVDFTTYNSAPSAPTALKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPELIFEGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNS
CLDILREKRFVQRTVFRLTLVKGFNIDDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALDKALAKRGLEYGIAAEHAHSCCVLIASKRFLINQKWHTL
IDYDRFFDLLDGPKEFKPEDYCRETPEWALWGNGGFDPRDERVDRKGRPKVKKAGGDDGG
EDKTGASTGEGKAQWDF
>A0A150UY45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidomyces richmondensis BFW|TrEMBL
IQPLIFYYTLTGTTKIHAERLATTHFSETLSILSPILHDLAAIDLDDFFTTIPSSKDPTT
AFFYLLLLPSYNVLDENNALAVFLAHLRDTHFDFRVDTAPLASLVGYTVFGFGDQGGWPG
EEFCRQAREADRWMARLSAGHRAWALGTADVSKGDVEQRLEEWAGGVRVVMEEIVERGGG
LGEAIEGSGDVLESEEEEEEEEEKEEEDEISSQPQQSIKPKKFRRMRPAQLSPTADLEDL
KFPVPVNFTTESRSNLAPLPMVPASSPTHAALTKQGYTIIGTHSGVKLCRWTKSALRGRG
SCYKYSFYGIASHRCMEATPSLACSNKCVFCWRHGTNPVGTTWRWSVDPPDMVFAGMKEG
HYRKIKMMRGVPGVRAERLAEGLKIRHCALSLVGEPIFYPHINELVGMLHRERISTFLVC
NAQHPDHLAALNHVTQLYVSVDAANPQALRQIDRPLHRDYWERFLRCMDILRERRMRQRT
VFRLTLVKGFNIEDEAEGYAQLVQRACPAFIEVKGVTYCGTASATGAGLSMKNVPFWTEV
VAFGRALEEALERRGMAYGIAAEHAHSCCLLLGDRERFWREGNWHTWIDYDRFFELCLGD
KEFGPEDYIGEATPDWAGWGRGGFDPRDERVDRKGRAK
>A0A1G4IUT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea meyersii CBS 8951|TrEMBL
MDLSKDLSDHLVTLSVVAAYVLSGGRLTVGLALTVVYGLIKYDSAKNRKDVVSQTLESAP
SPKKKKTCCGGKGGGCCSSKSGGKKGGCCGGNCSSKKKAREEEATSNDVKDPAFADVEDL
AMDFTDAFKPVKKTKTVRKIVSAAKPEAKNEPSFFRKALTISNEKLMSSQIYIFYSSLQG
AAERSAKIVKEVLSEVKDLKHVPEILNLDELSDFDDYFVNVPKSNALYIMVLPSYETDSP
LDFFLQSMDENANDFRIDKLALRKLVGYSVLGIGDSESWPEKFCYQAKQADLLLAKQGGR
RVFPVGEVCMKFGGDPSVMEWAKLLADTLQDDEPILYEYDESLETEEAEEPIDDPLKESL
VDLEDVGKSSELQDVTQVKEMVAKNSPTYKNLTKQGYTIVGSHSGVKICRWTKNDLRGRG
SCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDDPNYILENALKG
HYAKIKQMRGVPGVIAERFAKAFEVRHCALSLVGEPIMYPFINKFVSLLHEKKISSFLVC
NAQHPQPLRDLGKVTQLYVSIDAPSKIELKKVDRPLYRDFWERMLECLEILKTSQSHQRT
VFRMTLVKGFNMGEVNAYADLVQRGLPCFIEVKGATFCGSSDGNGNPLTMQNIPFYEECA
NFVKALSAELQRRGLGYDVAAEHAHSNCILIADTKFKKDGEWWTHIDFEKFFELLESGKL
FNHLDYTAKTPEWALFGNGGFAPGNTRFYKKRELQKQVTRTAMRFKAKSNLGKPLLHEKK
KGSPISL
>A0A066XL81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum sublineola|TrEMBL
MASSLGSAGFKDMLNNAHDAWQQVRIPVILFAAFGLLVLRFYLHSTEEKGELKAIPNLYN
REKSATKLVEEKKEAKTDVEPSPPSPTAQPKAPKSNAPKRIKGGLVKRASSDSSKGEALA
RKIRPLVFFSSITANTSKIAREYAERLEKELQKAVTNTKCLFATPEVLDLAEVDFDDYFI
TPPKSEEDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFG
DREGWPTEDDGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVIDVLG
MLAKTGSLGEGLPGSGAPEESDDESAEEDDDEVLIEDSEAKPEKLKNRKNIDDVEDLGRI
MKSSNPDADTRSRTAAAPIAIDFTTYGKTAQKKTPTSAAKEMVPKNSPTYTSLTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPELIFDGVKANHYSKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERFQRCLDILREKRFKHRTVFRLTLVKGFNVEDEVEGYAQLVEKGLPCFVEIKGVTYC
GTSTASNAGLSMSNVPFYWEVADFVKALEKRLNEKGLGYGIAAEHAHSCCVLLASERFYV
NGKWHPRIDYQRFFELLEERGPDGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRK
IER
>A0A135VSW4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thorarchaeota archaeon SMTZ1-45|TrEMBL
MPIELSEKLEKQGYHLLGSRGAYKACQWQKKALLHDTSCYKQRFYGIQSHQCLQMTPVVD
KCTQSCEFCWRITPSDIGVSWNQIDVSISDVMPVKELMDAVFMANLRSLGGYNPEVNAMV
PERKYKEARDPKHVAISLAGEPTLYPLLSDLIDEIHQRGMTSFLVTNGTQPDVLSTMSLP
TQLYVTLAAADESTYKTLCRPGLRDGWTRILKSQETLQSLSTRTVNRLTMVANRNMHNER
AYSRLIEIGEPDFIEVKGYMFLGSSRGRLDQNNVPTHREIYAFSERLAALTGYYLLDEQV
ESRVVLLSRSKQIKKL
>A0A1S7UJU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rosellinia necatrix|TrEMBL
MASNETKMDDSGLKSLGDFLEFWHIHREVIVIVVVSFFSMSWVLYSTLPTRRTVKKVPKR
TIVAAKPVPIKPVVTSDGKPEAPSEAQSEAQSSGITARGPRRIKGELRKPEATRRASDPD
SSRRTQILVFYSSLTTTTEKIATDLARNLDASLKKDTTEHKNIFFSPTTLDLAEIDYDNY
FISPPKTTDSAIPIDYFYLFLIPSYNIDTTNDNLLEHLQETHHDFRIDTAPLSGLLGYSV
FGLGDREGWPTEEEGFCFQAKEVDKWMAKLTGRKRAYPLGMGDKKQDLASRLGEWIEGVV
DVLILAATTGSLGEGVPGSGDADESDFEYASGDDDDSEILVEESAVPKNKANKRKANIDD
VEDIGRIMKSNQADSDGPKESAPIAVDFTTYNKPKARKAPQTVKEMVPKTSPTYTALTKQ
GYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEMIFTGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPHINEFLAMLHAERISSFLVCNAQHPDQLAALRAVTQLYVSIDASNRESLRKIDRP
LHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVDGYADLVERGLPCFVEIKG
VTYCGTSTSAGAGLSMANVPFYAEVTEFVTALDRKLKERGLDYGIAAEHAHSCCVLIASG
RFRVDGKWHTRIDYQRFFELLEERGADGDWKPEDYMGPETPEWATWGNGGFDPRDERVDR
KGRKIEAS
>A0A7K3Z3L6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crenarchaeota archaeon|TrEMBL
MDELLEQRLITALKKQKYHLIGKHSAVKRCKWLYESIVNNRPCYKQKFYGIQSHRCIQMS
PSLYYCTQECLFCWRIQSGDLETKWNEMHNPNRDTPEQIVEGCFRAQEKIISGYKGNEKT
DWVKLREAQRPNQVAISLTGEPTLYEPLGELIELFKKKGLTTFLVTNGTLPTRLLNLKQE
PTQLYVSLCAPNENVYNKVCRPQFSSAWSKLNETLETLQSFRCPTAIRMTMVKKHNMELI
EQYSKIVNKANPTYVEVKAYMHIGFSNLRLSFDNMPMHEEVKEFAAELAKHTGYNVLNEA
PESRVVLLSRLKKPIQVGNR
>A0A1Y2H373|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lobosporangium transversale|TrEMBL
MSSSSALQLWKEYRIPLVCMAFAIATLSIILSNKEKVNSNTNNTNEDKENNSDSKRDKDA
SENKEPPNEVEGIVQDMEHDPTIPTLSPAAVSRVMDHATAEQKPYRHQGLKKEEFRKLPK
VIRKKPKNKKQADPVTTSASAPIVTSSTVDGCCGGKNKPAGDTSTGCCGGKYKNENNHNN
TMVDDDGNIITASVPTSTVSNGCGGHACACSSTNGFAPTAPAKIDPLLLPMLTEPMKVFY
STITGTAKLFAQELAQSVASRGLPEPKLIDIVDYDTEDFLSESSLCIFILSTYNVEGPND
WFLKWLEDTRFDWRVERESLKKLKFSVFGLGDSAYGDEFCNGPRSADKWLGQLGAQRVWP
FGEGDKNGDQGGAFKQWNDALLESLLDPNQSHVHEAYFSSDEEDGASASEHDDDGEFDED
GQAVKKTKEEKLGLPTIDGGSTSEGDMVDVEDMGNVARKIRQAKEDKALDEEAYANQKVR
AKRMIGETKDGRAIKPREVREMVSPLLYKSLTKQGYKIIGTHSGVKICRWTKAALRGRGF
CYKHSFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTEWRWKVDDPEFILEGALENH
YGMLKQLKGVPGVRADRFVEATQVKHCALSLVGEPIFYPHINEFVKLLHKKRISSFLVTN
AQFPDAIASMDPVTQLYVSVDASTKESLKKIDRPLFRDFWERFLDSLDALGRKGQRTVYR
LTLVKDFNTDEIANYVELIRRGQPDFIEIKGVTYCGYGGASGLTMANVPYHTEVVRFVEL
IQEQLGAGYEIAAEHAHSCSILVASTKFKKDGKWYTHIDYDKFFDLVESGEKFTSLDYMA
ETPSWAYFGAPEGGFDPEETRYFRKSKEQRKAERERQQEVEMQA
>A0A7K4SKA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Burhinus bistriatus|TrEMBL
LDVSMDTWNFFYTCLVSLWLRRFYIYSVVAFGISIWFVVQFFTTKTKKKVTEHGEKSNVN
PASSEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFAAGLAEAVISFNLPVEVI
SMGDYDPEDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WKAKFLSRLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDHEHGASEYENTEAEELFET
SSEEEADAEEAGGTNAVVDVEDLGNIMSYMKKAKVLLFQQLCVSITGIDVLIYFLFSGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIM
YPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFK
DFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYANLIALGKPDFIEVKGVTYCGE
SSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKVNGEWYTWI
NYDRFQELAREHGRSGGSKTFTAADYTAKTPRWALFGSRERGFDPLDIRYQRKNKARDIS
GC
>A8ACF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)|TrEMBL
MGLQRRGRLLRADVVSTILERLRKAGYHIVGSHSAVKKCHWTHVALTERRFCYKCKFYGI
ASHRCLQMTPAVIWCWLRCLHCWRAEPGDLGLQWDDTKLPTVDDPAFIAEKSIEEQRKII
SGYKGHPKVDPKMFEEAMNPKHVAISLSGEPTLYPRLSELIEEYYKRGMTTFLVTHGVRP
DALAELDPEPTQLYLSLEAWDEKSFKEFNRPVLPGLWSAVLQSLDILPSFSSPTVIRITL
VKGFNDHERALEGLAKLVERGYPTYVEVKAYMNVGYSRYRLTKENMPTHAEVRSFAERLA
EKIGYDVVDEQRSSRVVLLSRIGKPIRVGEGCPGGKAGELPEGTEYELSERVK
>A0A256Z714|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon ex4484_36|TrEMBL
MPVLPHVREMLRKQHYYLVGEHGAVKLCHWLKKKLTEGRACYKENFYGINSHRCLQMTPA
VDICNHACIYCWRYQAPQEWPLNVRSSGGWDDPRELVEGLIEGQRALLTGYKGNPKTNLR
LWEEAQNPNQAAISLSGEPTLYPHLSELIEEFHRRGFTTFLVTNGTMPEVLERLDPLPTQ
LYISVDAPNERIYKSLCRPYIRDGWERIKKTLELLPSLDTRKVVRHTLVEGWNLGYVKDY
ARLDKVASPEFVEAKAYMFVGYSRQRMRIDNMPSFERIKSFAEELSRELGYTYHAEQPPS
RVSLLISDPKRVKVRLDN
>V5IN64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)|TrEMBL
MPFEIPGLNPAAIAEVARYAVELWHEHRIPILLSTVFLLGLLRTYLHLYSEPRQELLVLP
KIYEPNEKTKETTLVETEVKDKKTGAAITKKAKTAKGGPKRIKGDKVRTKKGTNGNDTGS
ESEGPRKIQVLVFYSSLTGNTERYTKDFAKELGDLLVGQSDAESKAESNFLAPQVLDLAE
IDFDDYFLSPMKGPVDYFYCFIIPSYNIDSINDTFLAHLDETHNDFRIDTSPLASLIGYS
VFGYGDRDGWPTEEEGYCVQAKQVDRWMAKLTGRKRAFPLGMGDYKRDGKERLSEWQNGI
VDVLKMIEQTGSLGEGIPGSGDPFESDEEDIAEDDGEVVYEESESKKTLEDVEDLGRIIK
QTQGDGQAAPIAIDFTDFGKTGKTVHARKSATVTVKEMVPKNSPTYTSLTKQGYSIVGSH
SGVKLCRWVKSAMRGRGSCYKYSFYNIVSYCCMEATPSLSCSNKCVFCWRHGTNPVGTSW
RWVVDPPDLIFNGIKENHYKKIKMMRGVPGVISSRFTEALRIRHCALSLVGEPIFYPYIN
ELLGMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKDSLRRIDRPLHRDFWER
FQRCLDILRERRFRQRTVFRLTLVKDFNIEDEIEGYADLVERALPCFIELKGVTYCGTST
AGAAGLTMANVPFYQEVCDFVVKLNDALNKRGLGYGIAAEHAHSCCVLLASDRFKVDGKY
HTHIDYEKFFDLLEEKGPDGDFTPEDYMGAAVPEWATWGNGGFDPRDQRVDRKGRPIERP
>A0A7J9IMH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium armourianum|TrEMBL
FYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKALAQRLLDLLSSKNNIPFDLV
DPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLADISTDFRAGNLLLSDCKFAV
FGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVDGGELESVFEGWSEKVVTVLK
GGLVMENENGIVYESDVESLESDDDDDGDGGGEDIVDLEDIAGKGPSRKKSVNVAETNGK
LDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCM
EATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAIDLHTKMIKQTKGVPGVTQ
ERLMEGLSPRHCALSLVGEPIMYPEINSLVDELHRRRISTFLVTNAQFPEKIKMLKPVTQ
LYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQRTVYRLTLVKGWNTEDVDAY
SKLFFLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVRAFSEALALKSEGEYEVACEH
AHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFDSEDYMALTPSWAVYGAEEGG
FDPDQSRYKKERHHKSKR
>A0A8C3BKC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cairina moschata domestica|TrEMBL
MEMWNCFYTCLASLWLHRFYIYSVIAFGISLWIVVQLFTTKKKGEKSNGNLSSEVVEEKQ
ANGYAALQAKEVYVAGVKIFYGSQTGTARRFAKGLAEAVISLNLPVEVISMGDYDPDDCL
AEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSCLQA
LCRGEKKPCSGKCKKGKCKSQGKQSKESSDHDHGASEYENAEAELVETTSEEEADAEEVG
GTNSVIDVEDLGNVMSHMKKAKRERELEEGHVGTSLSGETAGRKEAGEKREMITAALRDA
LTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVAGVKADRFEEAMTAKHCALS
LVGEPIMYPQINRFLKLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVQELVEFIPDYEIACEHEHSNCLLIAHKKFKVD
GEWCTWINYERFQELVREHERSGGSKTFTAADYTARTPRWALFGSSQRGFDPLDVRYQRK
SKAKDISGC
>K3V190|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium pseudograminearum (strain CS3096)|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTICIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEQVEIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPLVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKAHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAKESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A673C1I2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
PQRSQLNLLVLSVSHSAQSPALSYITSIWHNRLYLYSAAAVFVGIWISLKMGLKKQSLSA
DTAPKVYKAEKKNGCSDRDAVVHVSGVKIFFGSQTGTAKGFAKQLSEEVQTLGLTCEVID
MKEYDPDDRLADECTSRSVCVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAW
KVKFLNRLQNLVKGDKKSCSGNCKNGGSCKNKRKDGHGQEEEEDAEDLMESSSDEDESGL
QEGKKSVVDMEDLGDIMTSVKKAKSKEEGQMVKLSKLNGVKKVEDEGERREMITPALREA
LTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDPPEKILQDSLEKHENMIRQFRGVPGVKPERYEEGLAVKHCALS
LVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKK
IDRPLFKDFWPRFQDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVK
GVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVD
GEWWTWIDYERFQELVQVHEDSGGQQSFSALDYVAKTPRWALFGAEEQGFDPNDTRFQRR
NKTKDISGC
>A0A446BCA8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermothielavioides terrestris|TrEMBL
MFPDSRGVSPSIMSEVASYVLELWHEHRIPIIMSTLFVLSLLRIYLHSTEKREKLLVIPK
IYEKVPPNLVAGAEKKSKTEVRKDDSEGSESTGTGNEKWRAKDGPRRIKGNASRKARSRA
ESGREARRIQVLVFFSSLTGSTEKNTQLLAQELATALGCTAEEESGRTFLPPRVLDLAEV
DYDEYFIAPPKPESEQTDYFYLFVIPSYNIDSINDNFLEHLRETHHDFRIDTSPLAPILG
YSVFGFGDREGWPTEDEGFCFQAKEVDKWMAKLSGRKRAYPLGMGDWKRDGKQRLSEWRT
GLVDVLKQVAQTGSLGDGVPGSGDPIESEDEGEAEDDGEVLEETVDAKGAKRSSGGIEDV
EDIGRIMELSRADGSREKSAGPLAIDFTTEGKSATKKSVTVAIKEMVPKNSPTYTALTKQ
GYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPQLIFDGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPHINEFLGLLHGERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNRESLRRIDRP
LHRDFWERFQRCLDILRERRFRQRTVFRLTLVKGFNIEDEVEGYADLVERGLPCFVEVKG
VTYCGTSSSSSAGLTMANVPFYQEVCDFVVALEKALLKRGLQYGIAAEHAHSCCILLASE
RFRVDGKWHTLIDYDKFFQLLEEKGPDGDFSPEDYMGPPTPEWATWGNGGFDPRDQRVDK
KGRPIEAN
>A0A803M4P7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chenopodium quinoa|TrEMBL
MVSSALASRVTLLALLSATTFYCFYKSRCLKLASQKFAVSARNPKLIYITQTGTCKTLAH
RLHKLLASKGLVIDLIDVKDYEPEDLSKESLVLIVASTWEDGKPPPKAKFFADWIEESAN
DFRVGSLLLNKLKYAVFGVGSGAYGESFDVVAKGISKRLKALGANEVLPLREGDVDGGRL
GKEVDAWGEKLIGILKGVVQENGVIACGKLDDESDAEFVDESDDEDLEESEEELGVVDLE
DIAGKGPSRNSKNVAQVNGVKTDGKKEMVTPDKEKPLLLMLFSWHNSALRLVTADAKCME
ATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPVEIVNTALDLHTKMIKQMKGVPGVLEE
RLAEGLLPRHCALSLVGEPIMYPEINTLIDELHQRRISTFLVTNAQFPEKIKSLKPITQL
YVSVDAATRDSLKAVDRPLFGDFWERFLDSLTSLNEKHQRTVYRLTLVKGWNAEDVDGYF
KLVSLGKPDFIEIKGVTYCGSTATSKLTMENVPWHADVKAFSEAMALRSEGEYEVACEHE
HSCCVLLAKVDKFKIDGQWFTWIDYEKFHNLVASGEPFKSSDYMAPTPPWAVYGAVEGGF
DPKYVRYRKERNHKSKCQST
>A0A0G3CNG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina barkeri CM1|TrEMBL
MPLEEKKENAGENFPEAQNKNRKEDTASLPFDIPDFKTLLKKQGYALAGRHSAVKTCLWL
RHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPEKIV
EESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIKEYEKRGF
TTFLVTNGTVPEMFAKVSPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSLMKQKK
SRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVL
EFSQELAKHLGYEVADESEISRVVLLSKDGRKSPVNGKKISC
>A0A7N6B4P2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anabas testudineus|TrEMBL
LDPQDVHSSSYFMSIWHNRLYLYTAAALFFGIWFKNSKDVNSSVNKTEKSSERSDKQKVV
HVSGVKIFYGSQTGTAKAFANELSEEVKALGIPAEVTDMKEYDPDDQLADECTRKSVCVF
LVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYFGHYNTVGKN
VDKWLWMLSGMRIMTRGEGDCNVVKSRNGSVQADFLAWKVKFLKRLQALAKGEKKKCSGN
CKKGVGALSRGDIQPEPSGEDLMETSSDEEGSGLEDEKKTGSVVDMEDLGNIMNSVKKAK
IVKLSKLNGVKNIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPADKILQDSLEKH
QNMIRQFRGVPGVKPERYEEGLEVKHCALSLVGEPIMYPEINAFIRLLHSHRISSFLVTN
AQFPQEIRSLVPVTQLYVSVDASTKESLRKIDRPLFKDFWPRFLDSLKALGEKRQRTVYR
LTLVKAWNVEEMQAYSELIAVGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQ
LADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWINYEHFQELVQAYEESGGQQSFSA
LDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDITGC
>A0A8H6FI85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Letharia lupina|TrEMBL
MEVFGRPASGSKDRGILIYAFILDQWHEYRYLLLLAAVLLGLAVFLHFDNRLRRERLTSS
PAANTPEYGTVEKLGWLNEKSKSTILAEREDERSEKAEPDENVAMQFPNVSVRPRPGPKR
VTGSKGDRKPKSESSAHRRIQPLVFFSSLTGTTEIRALALLKELHTLLKDHSSTVLEPQI
HDLSYIDYDDFYVTPPKSHQIDQHVQYFYLLILPSYNIDTTLDTFLAHLQETHNDFRIDT
APLSGLAGYSVFGFGDKEGWSTEKEGFCSQAIEVDKWMAKLTGRKRAYPLGLGDVKSDSE
RRLGEWRDGVVKALLDIAANGGLGEGVAGSGDAVESEEEDADEAAEPGTVLKVEARRPAK
RKRQQKNSPVDDLEDLGGKSGDASEFRSPLPIDFTTSSLTSTTPQAPKAMVPVSSPTHAA
LTKQGYTIIGTHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMETTPSLSCSNKCVFC
WRHGTNPVGTTWRWQVDPPEMIFDGAKEGHYKKIKMMRGVPGVRAERFQEAMKIRHCALS
LVGEPIFYPHINEFVAMLHREHISSFLVCNAQHPDQLATLKSVTQLYVSIDASNAESLRK
IDRPLHRDYWQRLLRCLDILREKRFRMRTVFRLTLVKGFNIDDEVEGYADLVALGLPCFV
EIKGVTYCGNSSSAGAGLTMQNVPFYDEITTFVEVLNVALERRGLEYGIAAEHAHSCCVL
VASKRFYVEEKWHTIIDYEKFFECLESGKDFSPEDYMGPPTPEWATWGNGGFDPADERVD
RKGRPKVEKLR
>A0A1V8T3H7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rachicladosporium antarcticum|TrEMBL
MVNQELLLPDELLRFWHVHRVEALIVAGLVLLAVRLALHWRSKRVNAAKIADGTTTAELA
PTPEITSRHVEDVKHVLPSNAPARPKPGPKRVTGLRKAKPRNVQERTSLVRPIVFYYSLG
GSTRSYATQLAALLSQPKGAIETAPVEVLDLTEIDYDDYFISPPKHTATGRSISYFYLLL
IPSYDIDTELSNFLTHLEETHHDFRIDTAPLSGLAGYSIFGLGDQHEWPTERDGFCSQAI
EVDKWMAKLTGRKRAFPLGLADMRGSPEVKLEDWAAGVASMANDLATGTGLGEGVSGSGN
AVESGDEDEDAVLDDTEAKDDREGDVEDIGGRSPIPVDFTTTSRTKPTSPSAPKAMVPVS
SPTYTSLTKQGYSIVGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCS
NKCVFCWRHGTNPVGTTWRWQVDEPELIFDGIKENHYKKIKMMKGVPGVRAERFSEAMQI
RHCALSLVGEPIFYPHINKLLAMLHAERISSFLVCNAQHPDELAALGPVTQLYVSIDASN
KESLRKIDRPLHRDFWERFQRCLDILHTKRNTHRTVFRLTLVKGFNVDEEAEGYAALVDR
ARPSFVEVKGVTYCGTSTAAGAGLTMQNVPFYEEVCAFVLALEAALKRRGLDYGIGAEHA
HSCCILLADRERYYLPSGSNGESRWHTLIDYAKFFQLLESGDAFGPEDYIGDATPEWASW
GKGGFDPRDERVDRKGKPKDILEELPSAVMIREAEVTG
>K7G8D9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pelodiscus sinensis|TrEMBL
LDASVDVWSYFYAHLMSLWLNRFYIYTSAALGISIWICFQFITLKIKKQLKVTEDVLVNG
YTGPKAMKVYVAGVKIFYGSQTGTAKGFATVLAEAILSLNLPAEIINMRDYDPDDCLAEE
ATSKNICVFLVATYTDGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLGNSVYV
DHYNTVGKNLDKWLWMLSASRVMTRAEGDCNVTKSKHGSIEADFGAWKAKFLARLQALCK
GEREPCSGNCKKGKCKSKGKQSKEGSDHEQRMSEQENNEVEELFETTSEEELGSEEDGSH
NSVIDVEDLGKMMGHMKKAKKKQQLAPQKEAVGHQSIGKNEERERREMITPSLRDALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEMILREAIENHQSLIKQFKGVPGVRVDRFEEGLVVKHCALSLVGE
PIMYPEINTFIKLLHCHKISSFLVTNAQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRP
LFKDFWQRFLDSLKALAKKEKRDIYRL
>K7G8D9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chinese softshell turtle|TrEMBL
LDASVDVWSYFYAHLMSLWLNRFYIYTSAALGISIWICFQFITLKIKKQLKVTEDVLVNG
YTGPKAMKVYVAGVKIFYGSQTGTAKGFATVLAEAILSLNLPAEIINMRDYDPDDCLAEE
ATSKNICVFLVATYTDGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLGNSVYV
DHYNTVGKNLDKWLWMLSASRVMTRAEGDCNVTKSKHGSIEADFGAWKAKFLARLQALCK
GEREPCSGNCKKGKCKSKGKQSKEGSDHEQRMSEQENNEVEELFETTSEEELGSEEDGSH
NSVIDVEDLGKMMGHMKKAKKKQQLAPQKEAVGHQSIGKNEERERREMITPSLRDALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEMILREAIENHQSLIKQFKGVPGVRVDRFEEGLVVKHCALSLVGE
PIMYPEINTFIKLLHCHKISSFLVTNAQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRP
LFKDFWQRFLDSLKALAKKEKRDIYRL
>A0A1E3NR91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pichia membranifaciens NRRL Y-2026|TrEMBL
MSKLKKSPDTDVYTSNKTKFSDSPIYIFYSSLTGASKRVATQLFETLTASGNHKNAVQML
SIDDDVEDLDTYFLNIPKSEDPNNTNFPIYILILPSYESDSPIDYFLEFLHDTATDFRVD
KYPLKALSGYTVLGLGDSESWPDLFCYQSKIADKSMSKLGARRIFPLGRLCVKNDLKETT
AHWVNRLVSVLSDDEPFLYEENDPEDSDSDTDDVEEYSSENENETGNGSDDGTLVDMEDL
STDNKTRGSGKLTKSINKKQMVAKDSPTFKSLTKQGYTVVGSHSGVKICRWTKSALRGRG
FCYKFAFYGIHSHRCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWEVDQPDKIVEGALAG
HYTKIKQMRGVPGVLMDRFEEAFKVRHCALSLVGEPIFYPYINEFVKMLHEKDISTFLVC
NAQHPDQLRTLNKVTQLYVSIDAPTKQELKTVDRPLFRDYWERLEQCLDILRTVQSHQRT
VFRLTLVKGFNMSESDVGGYADLVERGMPSLIEIKGATYCGSSEGNGNPLTMQNIPFYEE
CVSFVKRLDNELNKRGMQYGLAAEHSHSCCFLIANKKFYVDNKWHTHIDYDKFFKLWNSN
QSFDSLDYICETPEWAYFGSKEGGFNPADTRYNRKDEKLKKKLQREKESKGGM
>A0A0W8AZ29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora nicotianae|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A225X3H3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora megakarya|TrEMBL
MLSPSGAGLSLLLVAVGVLLYLQTQPRIPPSDADATSTRKAPKSRKHEHGKPKPKKPKKL
TVRILYGTQTGASKTMAETLEKTLFALNIAGFHFQTSVVSMKDYDQDNLEQEAIVVAILS
TWTHGQPPEDAKVFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLDS
NLSDLGSPSLVTLGLGDDNVDQFKQFDVWMDNLVAAMCEYSSVKEVAALKKSSSPVKSKT
GKKEWLSQKEFRRQKRAKKAEAAAANGESVELNEEDLMNEQFLVDDFSDDEDERPHDAND
DSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLR
GRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGS
IERHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSF
LVTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQR
TVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRG
FCSALCERVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELVAKYYEDGST
FTADDYTAPTPHWALYDSQEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>K4A6V2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Setaria italica|TrEMBL
MPPFPTATTASATSHLALLVLLSSSSLFFLYKSIRLRRKPSPASGPARTTTPTLLYASVT
GTSKTLATRLSDRLTANAGVPILATDASSFEPDDLPSVPLLLLVVPTHDGGAPPPSAAFL
ARWLEESTADFRAGALLLSGLRFAVFGVGSRVYGETFNAASRNFSRWLRALGAVEVVPLG
EGDVDGGELEAVFEDWSGKVLRVVKGEELNEGVLGESDGLDELELEGEESDDDDEEETVA
VEIDMEDIAGKAPARQNGKVEGSLANGGQNGVKEMVTPIIRTSLEKQGYKILGSHSGVKI
CRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMD
NPLDIANAAIDQHTKMIKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVDE
LHRRHISTFLVTNAQFPEKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSL
KSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLTMEN
VPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHEL
VTSGKPFKSQDYMALTPSWAVYGAEEGGFDPDQSRFKKERRHGTAALKG
>A0A452F9V4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capra hircus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTAPKASQD
LMMNGYMFRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPVAMINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALCKGERKRCRGNCKKGKCESNQRSSEAAEPGSHTQEELHHGDAEEEEPFGSTSEEESD
TEDHQSQNSVIDVEDLGKIMDHVKKEKREKEPQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDDLQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGGEWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>A0A1H6FYH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum sediminis|TrEMBL
MSNSAETGVDSGTDAKEGEDDGAMQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKYIY
YGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDGVEWDDPEAVVDASIDLQKRLLSG
FGGNDEVPREVFEQSMEPRHVAISLDGEPTLYPYLPELIDAFHDRDITTFLVSNGTRPEM
LRECDPTQLYVSVDAPERHTFDEVVGAMEDDAWDKLLETMNVLAEKDETRTVLRTTLVKG
ENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSAMPDHEEVLEFAEDVKSYMPE
FTECRGVPESRVALLAKQKDTWVPKLKKGSEFWERDPVVGD
>A0A094BYC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4513|TrEMBL
MANNDYFGADTASNATEHYIIVLWHTYRIPLILTALALLLITRTVLHLKVGREKIIYTPP
ATPTEKAPVVAANPPREQLIEKAPISAEVKKAGPKRVVGKVTRKKSPLRDQAASKDVKFQ
VLVFYSTLAGSTERTAKALTTKLGDTMKAGAEASQYEFLAPVAHDLAELEDYDEYFLNIP
KSEDGAADVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGD
REGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDAKVDAQERLDEWRQGVEDVLQN
LGQTGNLGEGVVGSGDADESDVEDADEDETEVQADGSVKLKRKSKKKATSSMDDVEDIGR
ILQKGQTESQEQDDEEEGAIDFTTYGKKNPKPVAAPKEMVPKGSPTYNALTKQGYTIVGS
HSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYL
NEFTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWE
RFQRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTS
SSAGAGLTMQNVPFYEEVCAFVLALTAALEKRGLNYGIAAEHAHSCCILIASDRFKKAGK
WHTRIDYAKFFEHLESGEPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRV
EGEEKKEEEEEDKPVLVEI
>A0A4X1SW68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPQWALFGASERGFDPKDTRYQR
KNKAKDISGC
>F6BC88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanotorris igneus (strain DSM 5666 / JCM 11834 / Kol 5)|TrEMBL
MEEIYQILRKQRYQIKNHTAVKLCGWVRKCLLENKRCYKSKFYGIETHRCIQCTPAVVWC
QQNCIFCWRVLPSDINMQGSLKEPKWDEPEVVFEQILKMHRTMIMGYKGVIDRVGEEKFE
EALNPRHVAISLSGEPTLYPYLDELIKIFHKNGFSTFVVSNGILTDVIEKIEPTQLYVSL
DAYDVESYKRICRGKEEYWEKILNTLDILGEKKRTCIRTTVIRHLNDDILKFVDLYERAN
VNFIEIKSYMNVGYSRRRLKLEDMLKPEEILELAKILEENSCYKFVDKSSDSRVALLVNE
NKKINPKIDF
>A0A524AIH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MVISARELAELERAGYRFVGKHKHGAVKVCHWTRKSLLQRGSCYKEQFYGRELGMRSHRC
LQFTPSLPFCDHRCIYCWRNINVTHSNWVGEVDEPADILDGAISAQRKLLNGFGGNPNVN
KNKLKEAQEPKHCAISLAGEPTLYPKINELVEECSRRGMTSFLVTNGMHPEVLEHLSEPT
QLYISVVAPDLETYEAVCQPTVPDGWGRLNRSLELMPSFTCRRVIRLTLVKGLNLKDAPG
YAKFIEKAAPDFIEAKSYMWVGYSRKRLTLENMPLHGEVREFSEALARETGYKLVDESKV
SRVILLKG
>A0A835VY59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chlamydomonas schloesseri|TrEMBL
MDVSSLLASLYTIGQIVWGVIVGAIIIAILQATKRGDAEASEPEPATSKDHARAGAAAAT
AIAADKADVAPSSGNSGHEASNSARSAPAPSASAAASGAADAQAVASTRAAAPTQAPAVA
VTVAGATATAAAPAVVAAPAVAVAAPRPAAAAPAPSAAPAAAPAPVPVPDATPVASAPTA
AIAGAPAPAPASTAAAPPVKIIYGSTRGTCKGLAEALAERLLAAAETAAAAAAGTTANGT
STSAAACCGGGANSTADAGGCCRQGDGEAAAAAAAPSSDCCKSSGAAAPAPQPRPPLLPF
SSVVVVDAAAYEPEQLLTEPHDTLVVLLLSTYEGGTPPASATFFCSWLEDAASDFRLGAG
ALGGLRFAVWGAGNSLYEANYNAVAKRVERQMLDLGARRFRPLGLGDEDAGDLRTQFATW
AEALVAKLVPQAAAAAAASGKGASAAEETEASDAAAGAEEGEDEEDDSFEYDDEDEEGGG
SEVDIEDIGGAGPRRGKKGTAAAAAAASNGGSEGGPPEMLNALIRGSLTKQGYKIIGSHS
GVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKTWK
WKMDPPDVIVDTALDLHCRMVREYSGVPGVKPQAVAEGLAPRHCALSLVGEPIMYPEINA
LVGRLHARGLSTFLVTNAQFPDRIQQLAPVTQLYVSVDAATPASLKAVDRPLFGDFWERF
TGCLTALRDKRQRTVYRLTLVKGWNMEEVADYAKLVDLGRPDFIEIKGVTYCGSGGASSL
TMANVPYHADVVAFGQAICEARGGEYGLACEHAHSCCILLARVDKFRKDGQWHTWIDYDK
FQQLAAAGGDFGAEDYMLPTPEWAAFGSEAAGFDPAQVRVKKVRRHPGRTGTDSESVAGL
EDVVLEEP
>A0A523W521|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQSLVSNKLIQLLKKQKYHLVGRHSAVKRCRWLYESLVHNRVCYKQRFYGIKSHQCLQMT
PTLFYCTMHCRFCWRAQSGDHGLKWSETQLPEWDDPEDIIEGAIQAQLKILSGYKGNPKA
DQEKYKEALTPKHVAISLTGEPTLYSPLDRLIRGFHKRGFTTFVVSNGTVPEVLSRLSEE
PTQLYISVSAFDKKTFLKTCRPQIPAAWEKLNETLSLLPSFKCPTVIRITLARNLNLEHP
ELYAQLIRKANPTYVEPKAYMHVGFSRLRLGFENMPTHREIQKFAAQLTKEMGYNILDES
PQSRVVLLSRLEKPIKLSG
>A0A2I2G0Q0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus steynii IBT 23096|TrEMBL
MAAPSLTEGLLTFWHSYRLHFFVAFLAIFVVARVYRVIQPKSKTASASSIPSSPRSQSPG
KAEKEVGDTKPQTTEKKDSTAPVSNETTTKPSGPKRVSGKKPLKVAGRRGGSDQTPLSFI
QPIVFYASLTATTERYAQMLMEDLRAAAQKQADPENRERGILPPKLEDLSYIDFDDYFTT
APKPPANSPGTRYMYCLLIPTYNIDTVLNTFLGHLEETHHDFRIDTGSLSTLAGYSVFGF
GDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGLGDVKSDAESALKEWSQGLQDIC
SDILKNGSLGEGVPGSGDALESDEEDADDSSDEGKPKSRKKAQTVVDLEDIKMSADNQGG
SGAPIPVDFTTGGKQPAPTSQSTGKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIF
NGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLEMLHAEHI
SSFLVCNAQHPDQLENLKRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREK
RHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNV
PFYEEIASFVVALNKELERRGLNYGIAAEHAHSCCVLIASERFHVNGKWHSRIDYERFFQ
LLEKEKADGTSFTPEDYMRETEEWAQWGNGGFDPNDERVYKKGKNKAIQPTEAETADF
>A0A497MDR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MIPDEAKDRFLKAGYRIVGRHSAVEVCHWTKESLRSGRVCYKEKWYGIKSHRCLEMTPAL
IWCTHMCLFCWRPLKYTVCGEPEADDPEEIIDGCIEARRLLLTGFKGNVKVDRRKWEESI
RPTSAAISLAGEPTLYPRISELLEAFKKRGFTTFLVTNGTRPDRLRGLSTEPTNLYISLC
APDEETYKRVNRPLIPDGWMKLNESLELMKSFKCRTVLRLTLVKGLNLKDPEKYAELILK
AEPDFVEPKAFMHIGEAQSRLPRSAMPTHSEILEFSKTLSRLTGYRIKDEAPQSRVVLLS
KT
>A0A6G0IUL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Larimichthys crocea|TrEMBL
MLSLLVAVWLLTGPVSASESKGSHTVNNPSGSFFMSLWHNRLYLYSAAALLFGIWFSLKV
ALKKKSFSKDVGSLVFKAVKNNDRDPVVHVSGVKIFYGSQTGTAKGFAKELSEEVMTLGL
PAEVIDMKDYDPDDQLADECTNQSVCVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGK
TYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRHGSVQ
ADFLTWKGKFMSRLQALAKGEKKSCSGNCKSGGSCKNKKSGGHEEKQEETAPQNNSSEDD
LIETSSDEESGLQEEKRSGSVVDVEDLGNIMNSAKKAKSREDGREDVQMVKLSKMNGLKK
TEDEGERREMITPALSEALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESH
RCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEEALEKHQNLIRQFRGVPG
VKPERYKEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVP
VTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLKALGEKRQRTVYRLTLVKAWNVEEM
QAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVSFVQQLADMLPQYEIAC
EHEHSNCLLIAHTKFKTDGEWWTWIDYERFQELVQLHEESGGQRSFSALDYAAKTPSWAL
FGAHEQGFDPADTRFQRRNKTKDVSGC
>A0A419JJV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Syntrophoarchaeum sp. WYZ-LMO15|TrEMBL
MDDWIRRLELQGYHLFGEHQHSATKPCLWLKKAMRGGEFCYKGRFYGVASHRCIQMTPTI
LCNQACIHCWRPFIELSEDDIVWDTPSELIQALLLEHRRILSGYGGSDTTDTRRLREAAE
PKHVAISLIGEPTIYPHLPAFIDELNALGYTTFLVTNGTNPEMLRRVRPTQAYLSLNAPN
RDLYERICHPDDDYWERIMESLETLSKLRTRKVIRLTMIKGVNMVDPDVYARLIHRAEPD
FIEVKSYMHLGYSRMRLDRSNMPSHNEIREFTGKIVDSLDGYAIEDESEISRVVLVMRED
FSDKRFLEV
>A0A5N3VHM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Muntiacus muntjak|TrEMBL
MYPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTIPKASQD
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPVAMINLKDYDPDD
HLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEATNDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGARRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGEGKRCRGNCKKGKCESSQRGSEAAEPGSHAQEELHHRDAEEEEPFESSSEEESD
AEDRQSRNSVVDVEDLGKIMDHVKKEKREKEQQEGETGVTRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKTCVFFIGIRILNHWTTKEVPSLCLLFSCSRFPLSL
TQLYIYILNILYHYDLSWEIGYKYKTFMLWLYFFTRAKYRITIISYHLSFKMKTLQLK
>A0A6G1AG49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crocuta crocuta|TrEMBL
LDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSKDKSVP
KATRDLMTNGYIALQKKDIFVSGVKIFYGSQTGTAKGFAASLAEAVTSLDLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCRWLEEASSDFRFGNTYLKGMRYA
VFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVRSKHGSIEADFRVWKTK
FISRLQALQKGEKKPCGGNCKKGQCESSAEEEPFESTSEEESGAEDHQNLNSVVDVEDLG
RIMNCVKKEKREKEHQQGSSALVRNTAKAEAPERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVKEDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWHRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPDYEIACEHEHSNCLLIAHRRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGSADFSAKDYMAKTPHWALFGASEKGFDPKDTRYQRKNKSKDISGC
>A0A0Q4BFS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon RumEn M1|TrEMBL
MTTDVRRTLEKQQYKMHGDHAAVKLCHWMQQSLLKGRTCYKQEFYGISSHRCLQMTPVVN
QCTHNCLFCWRVQGFEATNVQWKGPEEILDHCIEEQRKLVSGFGGDPRCTREKWQESREP
KHVAISLSGEPTMYPHLAGFIEVCHRRGMSTFLVTNGTLPEVLETLDPLPTQLYVTVAAP
NEDVYKRLCVPRIKDGWEKLNRTLELLPSLDTRKVIRHTLVKDWNVGWEREYAKLDEKAD
PTFVEPKGYVFVGDSRRRMTIDNMPSPTMIREFSDRLGAELGMEVLKERRDSRVAVLGRP
GAKLSLF
>A0A534K750|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MRSAVDSEKREVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMT
PAVDACNLACQFCWRTQEWGSDSLRVADDPSFIVDDSIRGQRELLSGFKGNPNVSPERFL
EAWHPTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQ
LYVTVAAPNEGIYRKLVAAKSDHEWKKLKETLALLPTLATRTVIRHTLVEGWNLGWEDEY
AELDRIGRPMFIECKGYSFVGESRLRLEANNVPSHASIRRFAEGLADRIGYQVAAEREDS
RVVLLTTDGQLHPILH
>A0A832ZQY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MAIRVREDIRKVLEDAGYRIYNHSGVEVCTWTKKALTQGEFCYKNKFYGVDTHRCMQISQ
AVAWCTNRCIYCWRATEDFMPGAGVLPKDAVDAPGDILERLREMRAKLLSGFGGNEKVDR
KMYEEALLPNHVTFSLMGEPFLYPYVPESVQYILDNWRWVKSVFIVTNGMVPDEVQRMKK
MGVWPTQFYVSFTAPDPATYRKVSNPLYPDYWGRFLETLRTLSDAPVRKAARITLIRGYN
DFCFDGWAELIQVYRPHFVEVKAYMYIGRSRQRLKEENMPTHDYIREWAAELCEHLDNFE
HMDEHVASRVVVLKNVGEGMDIDPVIRGPLPNLRLQKRSGA
>A0A6B9TEM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp. THM-1|TrEMBL
MYLEESQRRMERMGYRFVGEHRHSAVKTCLWTKKSIVNEGVCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTGTAWEGPHDEPADIIDGAIEAQRKLLCGYLGNERADKIKVM
ESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLSEEPTQLYI
SLDAPDRDTYKELCRPQIPGAWDLLNSSLELMPSFSCRKVLRITAVRHINMKDPEGFARM
IERARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDESRESRVV
LLA
>A0A2E7CD77|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKATLQKQRYHIVGEHGGVKTCHWTKESLVRXRSCYKGTFYGVKSHTCMQMSPVVD
XCNLAXTYCWREPHMDTLELSXQDPQELLYESVRAQRRLLTGYGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYKRLAEYMDLCHQHGMTTMLVTNGTLPKVLERLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWAQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAAIDR
RADPDWIEAKGYVYVGHSREHLSIDNMPSHEDILTFSXSLAPQVDMRILSESRPSRVALI
GNEMIPIPIPEATMHFPENLGIASPIKKLXLADVS
>D2HW32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ailuropoda melanoleuca|TrEMBL
LDPSLDTWDFSSPLMSLWINRFYVYLGFAFGISLWICFQIVIRKQDKNSREKSVPKATQD
LMTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFAASLAEAAASLDLPVAVINLKEYDPDD
HLLEEVTSKNICAFVVATYTDGRPTESAEWFCQWLEEASSDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTKFLARL
QTLQKGEKKPCDGNCKRGQCESELTIWERCYFEQCVSEALMFQEEEPFESTSEEESGTED
HQNPNSVVDVEDLGKIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITPALREAL
TKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVKHCALSL
VGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKG
VTYCGESSASSLTMANVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDS
EWWTWIDYNRFQELMQEYEDSGGSATFSAKDYMAKTPHWALFGASERGFDPKDTRYQRKN
KSKDISGC
>A0A2E7AV40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLXLTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFIEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQIFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSSNIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDXLSFSNELAPQVNRDVLSESRPSRVALI
GRXIVPIPIPEAEXYFPEDLGIAPPVKKLPLIQN
>A0A2E1I9W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPIIAAKLQKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIQSSGCMQMAPNVD
TCNLACTYCWREPHSETLNKVDTDPEMLFYESVRAHRRLLTGFKGHPSVTLEKWQEAQNP
KHVAISLNGEPTLYSRLAEFLEICHQHGVSTFLVTNGSLPKVIENLDTLPTQLYISVDAP
NKEIFNRICKPKYDNNAWEKLEQTLELLPSLDTRTVCRHTLIKHESLGHVEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHPEIMEFSEQLAPLVGREVLSDRRESRVALIGK
EMNPVVLPPQVREFPKDLGIAKPPPKFSLPTL
>A0A534L4K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPEKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPAVD
ACNLACQFCWRTQEWGSNSLLAADDPAFIVDESIRGQRELLTGFKGNPNVSRERFLEAWH
PTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHSEGRLPTQLYVT
VAAPNAEIYRKLVAAKSDHEWNKLRETLALLPTLPTRTVVRHTLVEGWNLGWEDEYAELD
RLGKPMFIECKGYSFVGESRLRLQAENVPSHASIRTFAERLADRLGYRIAAEREDSRVVL
LTQDGALHPIFQ
>A0A2E1QE85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLAKQSYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGYQEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSRGLAPMVDREVLSERRESRVALIGK
EMIPVKLPEKIRDLPKDLGIAKPQKLSLPTL
>A0A6P8H8V0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Actinia tenebrosa|TrEMBL
MATKDFCRNFQTSLFFSLIFITFLTITVKGDDNPDKTSVHTNEVSWSMIFKPVMGVVAGI
LGIWLWTTLKAKQDEEKLPKTRDPNQADKLTTSAIKIFYGTQTGTAKKFAEMLQELSTRQ
GTDCSVTSLKDYEPEDNLPNESCTCVFIVSTYTDGQPPEDAVWFCKWLEESSNDFRVQKS
LLGGVKYAVFGLGNSLYKDNFNMVAKNIDQWMTALSAQPAVPLRLGDENHINSKHGGIEA
DFEAWTKELLATFKSTSSCECGSQETCCKDEKNPQPLLKDSDEDAMYESSTDEDNDDESD
KNRKKDPKSSGMVDLEDLGPALRKMKKAKEMENGSLVNEPKEMVTTVIRESLTKQGYKII
GSHSGVKICRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVG
TEWKWQMNEPEMIVDGAMQNHFNMIKQFRGVPGVKLEKFEEAMKIKHCALSLVGEPIMYP
KINELIKLLHGHEISTFLVTNAQFPDAIKNLVPVTQLYVSVDASTKESLKKIDRPLFRDF
WPRFLDSLKALSDKGQRTVYRLTLVKSWNTDELKSYADLVALGKPDFIEVKGVTYCGESK
ASTLTMANVPWHQEVVGFVQQLVALLPDYELACEHEHSNCLLIAHKKFNIDGDWHTWIDY
SKFHELIRDYEDSEGKASFSSLDYMAKTPNWAVFGDEHRGFDPDETRWYRKNRKDISGC
>A0A3G1B0T7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis cloacae|TrEMBL
MSCSGEFVEDNEIIQIKSSIQQQLKKAKYGVSDHSTVELCHWTKKSFKGEESCYKHKFYG
ISTHQCMEFSPAGMYCENRCVYCWRPMEFYDSLVMDPTRVAEPQEIITKLMAERRGLIMG
HYGDPKSITKKLDESLLPAHYAISLSGEPTMYPKLPELIKYLKTLPATKSIFLVTNGQEP
QMLQRLQDEDALPTQIYLSTNAADYDSFMRINKPRYDDSWERWNKSLELLSKLNTRTVLR
MTLIRDHNNSESMIPSFASMIKRANVHFIEIKSYMHIGRSTNRLARSDMLEFEEVSHFAT
QLAKQSQIYSVMDESIASRIVLLQNQERLIDPFIAAYAQTS
>A0A0D2GUN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fonsecaea pedrosoi CBS 271.37|TrEMBL
MDLGEAGAAPVILADWLDRLLIYWHENRAVVSTLVGLCVLAVVVQRRHASKSAQHGSPTL
EKAAWLAPKDHAPVQTGKDQRLQSPSRITPSLTSGQARKPRTPAAAARVVTGRKPASSRG
QAALQRRREPSRMQPLIFFSSLTGTTERLAKQVAADLEGVSTAYPAILRPQVYDLSYVDL
DDYFISGPKTPVPSADVSYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLAG
YTIFGIGDKEGWPTEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSNVDKSLKDWVG
GVCSVLKEVSTSGALGEGVPGSGEPVESGDEEEPEDGDEETDEFPDSGRNKRRKLANTTD
LEDVGGKANSYTSPIAIDFTTYSSRPSPATTLKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPKLIFDGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNS
CLDILREKRFVQRTVFRLTLVKGFNIEDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALDKALAKRGLEYGIAAEHAHSCCVLIASKRFLIRDKWHTL
IDYDRFFDLLQSSTDFTPEDYCKATPEWALWGNGGFNPRDERVDRKGRPKEKKTSGGDDD
GTVSEARNGIKVGEQKADLDF
>A0A6A2F859|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedens sp|TrEMBL
MNSIPETTQSLLKKHGYHLAGTHSAVKTCLWLNKSIRNTGACYKSKFYGMTSHRCIQMTP
TLVCNHRCLHCWRAVEVPVQVPHVWDTPEEIVKAVFNEHKRLISGYGGSEFMDKTRWKEA
FSPKHVAISLSGEPTMYPHLPELIEEFHKNDMTTFVVTNGTIPDMVEKIKPTQLYISLNA
PDENTYEKACSPIGNSWENIKQSLEILKRSGTRTAIRITLTKGVNMVDPEGYARLIELAR
PDYVELKAYMHLGFSRKRLSQDNMPSHEEVLGFSRQVAEVLEYSIADDSGGSRVVLLSKD
GGKHNI
>W5M8W9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lepisosteus oculatus|TrEMBL
MIMLLWVSHILCDLILVTFAAETEDNWKDGWGYFHSCFMSAWQNRFFVYSVAAVCIAIWF
TFQMVMKKENKGVSSTLAQNPKNKKEKGIVAEKVNKVYVSGVKIFYGSQTGTAKGFAEDL
SIDVQSLGLPSEVIDVKDYDPDDSLAEEATSKSVCVFLFATYTDGKPTENALWFCKWLEE
TSTDFRYGNTYLKGMRYAVFGLGNSVYSSHYNTVCKNVDKWLWMLSASRIMTRGEGDCNV
VKSRHGSIEADFAAWKSRFLTRLQSLAKGEKKSCGKQCKSGRCKNKQKHQQPAEEESESS
PGKEEQSSEEELFETSSEEDFTQDEVATHGPVIDVEDLGQVMNQVKKAKKRGELEEDPGK
VMLSKHSTGRSDDEEAREMITPALRAALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKILKEAVENHQNM
IRQFRGVPGVMADRYEEGMMVKHCALSLVGEPIMYPEINRFLKLLHHHRISSFLVTNAQF
PEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFQDSLKALGEKQQRTVYRLTL
VKAWNVDELKAYAELVALGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVTHFVQQLAD
QLPDYEIASEHEHSNCLLLAHIKFKVAGEWWTWIDYERFQELVGELEESGGANTFTALDY
VAKTPRWAVFGAKERGFDPADTRFQRKNKTKDLSGC
>Q8TUM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)|TrEMBL
MPLEERKEEKENSGENFPEIPEENRGEEQSSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLKTYLRVCQPKSPALWDRINESLDIMK
DKCSRTVIRTTLVKGENIFNPKGYAELIKRASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGKKSPVKKISCQD
>A0A8C4EVZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
LQRCRIYSYSSLSSYVACLPRTVKVMSQNAHSPSESYLMSVWSNRLYLYSAAALVFGIWL
SLKMALKKVNCPLLMSHLHSSVKKDDRDAVVHVSGVKIFYGSQTGTAKAFAKELSEEVKA
SGIPAEVIDMKDYDPDDQLADECTNKAVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNG
SIQADFLAWKVKFLNRLQALAKGEKKTCSGNCKTGGSCKNKRKEGHEQEEEEEEEEDLME
SSSDEEESGLQDEKKSGSVVDMEDLGNIMSSVKKAKVRLYEDATLSKMNGLKKTEDEGER
REMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDPAETILQDALEKHQNMIRQFRGVPGVKPDRYE
EGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVPVTQLYVS
VDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKSWNVEEMQAYSELI
ALGQPDFVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLTDMLPQYEIACEHEHSNC
LLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPSWALFGAHEQG
FDPADTRFQRRNKTKDISGC
>A0A256XDS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon ex4572_64|TrEMBL
MLSIESCRFHALSDGKLRLTLDVEALLKKAGYGVYKHATVELCHWTRRALTEKRHCYKVK
FYTAPFGGSHRCVEFSPVGMICHNKCIYCWRVTDTYDYFIPEKNEVLEPEELVQGILKER
RRLLSGYFGHRKCSREKVLEALEPTHWAISLSGEPTLYPKLPELILYLRTLPNTRSIFLV
TNGRCPDMLEKLDHEDALPTQLYLSLTAPNEELYYKIHRPVLEAKNAWKIFNKSLELLST
LRTRTVIRLTLIKNINTDDKYIKEFAELVRKANPHFIEIKSYMSLGYSLHYLSRENMMRH
EEVKEWSRRFLREVNKDFKHFEYMDEQLDSRIVVLRSIKRKIDRYIKEVKPRVEN
>A0A834B717|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MGPSLDSWDFSPLISLWINRFYVYLGFAFAISLWICFQIAIRKQLFIFKDKNSQKKSVPK
ATRDLMTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPVAIINLKDY
DPDDNLVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEASSDFRFGKTYLKGMKYAV
FGLGNSVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEADFRAWKTKF
VFQLQVLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEEEEPCESSSG
EESGTEDHQSLTSIVDVEDLGKIMSHVKKEKREKEQQEEKTGLFRNTVKKEAGERRAMIT
PALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGVKEERFKEGMTV
KHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLTPVTQLYVSVDAST
RDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSP
DFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLIAH
KKFKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPWALFGANERGFDPKD
RRYQRKNKSKDISGC
>A0A087HIK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabis alpina|TrEMBL
MATSSSIRVRLAFVALLSATTFYCLHKYRRLKRLKNFSLNPSIAQTSKSTRGKIFFVSET
GTAKALAQRLHELFESNGIAFDLVDPRSYEPEDLPKETLVIFVASTWDGGKPPQNGEFLV
NWLSESAEDFRVGSLLLSDCRFAVFGVGSRGYGESYNAVAKELSSRMIGLGGVEMIPVGD
GDVDDGELDGVFQGWCDGVVRALKGGSGEETNGVLLNGGVESDGEYVDTTDEEDEDVDNG
DIVDLEDIAGKAPSRKNGVVVKKSNGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPK
EIVKGALDLHTKMIKQMKGVPGVTPERLQEGLTPRHCALSLVGEPIMYPEINALVDELHG
KRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKAL
QEKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGTSATSKLTMENVPW
HADVKAFSEALSVKSKGEYEVACEHAHSCCVLLGRTDKFKVNGKWHTWIDYEKFHDLVAS
GEPFTSTDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAQAVLA
>A0A6A7BJF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plenodomus tracheiphilus IPT5|TrEMBL
MALLDSLAQLPIELLYIWHAHRLALLLSAVVVAAVLRLWIYTRSRREKVSVSPTPSSPVE
KKFVDLKPEWLPEYTTTTTPSFPELNVDGHAEDTKTVPSIAKPRKGPKTVKGKKVQKKRT
IPAPIFDHNTDKIQPLVFFQSLSGTTERYAAQLAKVLTEWTAGCDQSSSFLEPQTHDISY
IEHDDFFITPPKADANVKFFYIILVPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLG
YSVFGFGDREGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKKEAEDRLQEWRL
GVQEALVEIAEGRGLGEGVPGSGDPAESDDEDTEDAEDNNAQSTRVDDVEDLGGMVTSNS
SSTAIPIDFTTYKSAPKTKSKPTSAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWT
KSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDDPDL
IFNGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLDIMHKN
RISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKASLRKIDRPLHRDFWERFCACLDILR
NRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGDAGLTMQ
NVPFYEEVAEFVVALEKELNDRGLSYGIGAEHAHSCCILLADRSRFMKNGRWATRIDFER
FFELWEG
>A0A7I8W699|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dimorphilus gyrociliatus|TrEMBL
MGRATTITLATSLGLAVALYVWHKKYRRSIKISEQKAQSFSKIKILYGSQTGTSEKFARI
LAKEAKEIHKIECEVISMQDYDPEDSLSDEAKNEIILVSIISTYTDGAPPESAKWFCKWI
EEASSDFRIQKSLLSNLKFCVVSLGNSLYEEYFGTVGKTLEDSFKKLDATMILPLGIVDE
NVAESRHGGKEGDFAAWKKKFWKRALRIIKNNEHIEVKNSKKSSKDCCSASCSCQGDKKT
EKNESDSGLSEEEEEENSEDVVDVEDLGNIMGKITRNAAKGGNEKEMITPMLRDALTKQG
YKLIGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWKWKMDEPDVIFKGALENHYKLIKQYRGVPGVKPERLEEAFRVAHCALSLVGEP
IMYPKINEFVKMLHEKRISSFLVTNAQFPDAIKNMVPCTQLYVSVDAATQDALKKIDRPL
FKDFWPRFLDSLSALSAKGQRTVYRLTLVKAWNTEELNAYADLVSLGKPDYIEIKGVTYC
GESKATTLTMENVPWHDEVLRFVQQLADLLPNYEIACEHAHSNCVLLADVKFKKDDGWYT
WIDYEKFHELSDRYKASEGKLQFTSEDYMAKTPTWAQYGAVERGFDPEEKRHFRKKANNK
DIGGC
>A0A1D3U8F0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium ovale|TrEMBL
MANGMMEEKRLEHYPPLRPFQMLSIRKKAKINFKVIYGSESGGTYKRAKEFLNELVEFFR
EIGSFFKDINRISLCGDNADGGSTNGCLIDTSELGSRLVAYFKSYLMEKEKNKAGLSRES
RGKRSRGRMTNGETQHLDIFKNGETESNEHFANCVDIFIENSISTVHIDFTSGNEFDSYS
FFENSQEYDLNILLLLLSTCNYGSFPKNCYKIEEILRDLLNDFRVGKNYLENVFYSCVGF
GNKQYGSKHFCAPIKECDKILTSLGAHKLYKTVKLCDEEDNDVTLLEWKSSLFKTLSLSL
FFYHFDFTKLRSNYVQYAMKKVYNSLKYYCSFFCEKDERDSNGHGEKVLSEVDVSFREES
DGAISPNVHVDENKKETIPTNATDEIDSKRRETFNCGSGDEVEDILFDTPKDMLSINQRE
KLTKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMETTPSLACANKCVF
CWRHHKNPVGTQWKWHKDDANMIVEEAIKKHRGMIKELKGVYGIIKERYDNAMNVKHCAL
SLVGEPIMYPDINQLIDELHKRNISTFLVTNAQFPSELKKLHKVTQLYISIDGPNRDALK
NIDRPLFKDFWERYIKCIKLLKKRKERTVFRFTLVKEYNMMSDEILSYAKLVEYGLPDFI
EIKAVTYCGSSEGYKLTMKNIPWHEEVYNFAHHLINCKSSITDAYDIACEHKHSCSILIA
KKIFKINNKWHTWINYENFQLLVKQGKDFTSTDYCAETPHWAVVGAQECGFNPSDKRVYT
KGRNKNRNPDETQRDSPVVVAPT
>A0A4Z1EU12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis tulipae|TrEMBL
MPYDSWISRPIWSHEIHDIVVLWHLYRIPIILTTATILILVRITLRPRTVREKLSASPLP
SSPVLLAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTANSFVESIRGDLSGRAIGQKIQFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTTGEELEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGEDKVAENSTKDDLAF
>A0A0F8QMJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 1.H.A.2.2|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPSMLAKINPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDFMK
KKSSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISCLD
>A0A2U9IV55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metallosphaera hakonensis JCM 8857 = DSM 7519|TrEMBL
MAVKGSFRIDTLSKIRSEMEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMTPVSMWCWFRCIHCWRLEPEDVGLEWDETKMPYMDDPGYIAERSIEEHKRSVSGY
LGREGVSDRKALEAMKPSHVAISLTGEPTLYERLGELIREYHKRGITTFLVTSGVRPDVL
ASLEEEPTQLFVSLQAPNAEKHKLINRPVVANSWNLVMKTLEILPSFSSPTVIRMTMMKD
VNMSERDAIEFSKLMELAMPTYIEVKAYMHVGPSTYRLTKDAMPRHFEVKNFAERLADLT
GYKIISEHAPSRIVLLSRLDKPMQIGNAWTEKWDWRTQDTQDDINGEYREAEVGCTEEGE
GQRS
>A7ET36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)|TrEMBL
MAYDTWISRPIWSYEIDEIVALWHLHRIPIILTTATILILVRITLRPRASREKLSASPLP
ASPILPAVKEKISPPVIEEKKTNGVKAPRRIVGGVKKRKPSEENLQTSPEKIQILVFFSS
LTGTTERTASSFVEQITGDIRESGFGGEAPIKYLDPELLDLSYIDYDDYFINPPKGEPRT
SYFYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEE
GFCSQAKDVDKWLAKLTGKKRAFPLGMGDAKKDARERLTEWREGLVDVLEHIAKTGSLGE
GVVGSGDAVESDVEDIEDDDGEVLFDEQNVASRKVKTQKKEDSLNDLEDIGGVLINTETI
DNTVGEGSEELESDFTTVRLKKGKVKTAPVVAKEMVPKTSPTYAALTKQGYSIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWK
VDPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFT
SMLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQR
CLDILRERRFEQRTVFRLTLVKGFNIDDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAG
AGLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTR
IDYKKFFECLESGEKFGPEDYVGDETPEWATWGKGGFDPRDERVYRKGKNKVPLPESQGM
VMGEVQDGNEDTVAGDTLAF
>A0A1X7R7D4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kazachstania saulgeensis|TrEMBL
MDLKSKVYVTLGLTSPIFLYFGGRLSILVVLWTSVILFGKEIFGKDNEATGEPHKCKCSG
KNANGETHEHNHEKEDCCGGKGTGVNGKPCCGKGGKSTTTSQLPTFKKELLKSQDEQKAK
IKCCGGKGHDVKKHGEVCCGGKGHAEEKKIEPLEEKKSKTKCCGGKGHDVEKHGKVCCGG
KGHGNEKEEVVPIPEPVTEKQETKCCGGKGHDVKKNGKVCCGGKGHRNEKKTDPIEEKNT
NNWDSLTVDFTEAFKSTTGKTTKKSVKVFTKKGMTEVKATQSEESSDGLIKSAFTVSNVE
LLDSDIYVFYSSLQGSSSKAGSIVQEKLKEISGLQKQPILLNLDEIDDLDEYFVNVPSEK
AIYVLVVPSYDVDCPLDYFIQTLEENFNDHRLDKFPLRKLVGYTVLGLGDSESWPDKFCY
QATKVDYWISHLGGRRIFPVGKVCMKYDGNDKVIEWATLLGDLLKDNEPILYEYDETVDN
SDDDYDDDNGDSDGSNGNDDGSEKDIDLEDVGGKDDNRINENYLEIKQMIAKDSPTYKNL
TKQGYKIVGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCW
RHGTNPVSKNWRWETDEPEFILENALAAHYSMIKQMRGVPGVIAERFINAFKVAHCALSL
VGEPILYPYITKFIELLHEREITSFLVCNAQHPESLRTIGKVTQLYVSIDASTKEELKKV
DRPLYKDFWERMMECLDILRTVQSHQRTVFRLTLVKGFNMGEISSYADLVQRGQPCFIEV
KGATFSGSSKDNVNSLTMQNIPYIEECKAFVERFVGELQRRGLDYEISAEHAHSNCVLIA
HRKFKINNKWHTHIDFEKFFKLLAKGEPFTYMDYLKETPEWALYGNGGFAPGNVRVHRNE
KKKKNDNGDNRVNPEDLPALPVM
>F4RMT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7)|TrEMBL
MSKQEQEQEEEVKVLILYSSLSNTTKSLSFQLQNSINLTSSTTSKPRIHSLHDFDLDQII
LTTSNTIILFALPSYNVESPVDSILAQFKDSLYDFRFSKDSLNQIAYGVIGIGHIDYGQE
FCKQAIELDFILDSLGAKRVIELVKIDVSVDPELQLGQLVDQINQNFSNKSFKSVSELEI
IPIEALSLKNSELNLIDDEEYDSDDDYVEYDQDRISKPLSKLELAKRKSKAKQKNHSSAQ
KDDGADIEDLGVGIPQSSTDELSILPNHQVVTQDLRKEMISPMTRKSLTKQGYAIVGSHS
AVKTCRWTKASLRGRGFCYKHTFYGIQSHRCMEATPSLACANKCTFCWRAHTNPVGTSWR
WKTDDAEFVIEESLKEHDRLIKQLLGMPGVRPDRFLEARTPKHAALSLVGEPVMYPHIKK
YIELLTEKRISTFLVTNAQFPDSLKDLPPVTQLYLSIDAGNKSSLKSIDRPLHRDFWERF
LESIEIVKGMKKTRTIFRLTLVKGENSEEILDYVELIKRGRPDFIEVKGVTYCGYAPSSN
LTIKNSPFHEEVVNFVQALCYELNSTTDDPNLQYDLASEHAHSCCVLAAHQKYRIDDQWH
TWIDYERFFDLVEEGKEFDGTDYMALTPDFAVFGAPEAGFSPEDVRWFRKGKGPKESEAE
AQEAEEEETIGGK
>A0A6L0XVQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium sp. DRC-Itaito|TrEMBL
MGILEQEFLLKNILGTQCNKEKVKISISVIYGSGDGNSYNRAKDFINELIEFFKNVHLFF
NDINEIINKNIYMNDINGNMHYGDILPKKDSIEINDSYKNDDNVDHDNTDSNIIYKNNYI
NTSLDIKDMNSLENEIIEYFKLRFDKYQGNNKKRKEKISRSGYENMIPLYYNKNINYLEP
YKENIKMLNSKFKNYVDCTIDNNKIGKIYFNLIDGNNHDYYSFFDSTENYNLNVLFFFIS
TSSHGSFPNNSFKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKKCE
KYIHLLGAQKLYKTLKLCDTEDNEETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKRTY
DTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKPDSEKKKKKKKKKKKTDLSIYPIDQLEG
CHCNKEYQENNIRIDQNNINYNNNKCWNNEIYNTQNDIYNNVKGDHQITLSNIDIVEEDL
MKEYKTKMDKTNKMMNEKREEVDVNRDVFLMREDTQGIEGHTNCKCKSVNEYNDKSNTNN
INTTSIINNINTTSIINNINTTNGINNINTTSIINNINTTNSINNINTTNNINNMITCEN
SISESEASSNESYADDENEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLC
RWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDN
AEVIVEEIIKKHKAMIKELKGIYGIILERFEKAMNIKHCALSLVGEPIMYPEINKLIDEL
HKRNISTFLVTNAQFPVELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIK
ILKNRKERKVFRFTLVKEYNMMENEINSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMK
NIPWHEEVYQFAWNLINKKKSLSDIYEISCEHKHSCSILIAKKIFKINNKWNTWIDYEKF
QQLIKNKEKFNALDYSVQTPDWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A2P9CL12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium sp. DRC-Itaito|TrEMBL
MGIVDQEFLLKNILGTHCNEKKVKINISVIYGSGDGNSYNRAKDFLNELIEYFNNVHLFL
NDINEIINKDIYINNVNSKNNYSDMVQKKDYNEKKIEIINNYKNHKCDDHDNVGSNIIFK
SNHINPSLNRNHMNILENEIIEYFKLRFDQYQVNNNNNNKKKKNKEEISRSGYENMVTLY
FNKNINYLESYKENIKMFNSKFRNYVDCIIDNNKIGKIYFNLIDGNNHDYYSFFDSTENY
NLNMLFFFISTSSHGSFPNNSFKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDK
YFCIPIKKCEKYIHSLGAQKLYKTLKLCDTQDNEETLFLWKCNIFKTLSLSLFFYSFNYM
KRWYMNKTIYDTLSYYCYFFSNHTNFYVNQSEDNKYIHDQEEKEKKKKKKKKKKNSHDHS
INSIDLLEVSHSNKEYKENNPLIDHNNNKCFNNEIYNTQSGIYYSNVNDVQQMCLSNIDN
EENNLVNNEKKKINDKTNITMNEKREEVDVNEDIDLLHGDIQKIEGCTNCNCESMNEYND
KNNTYHTNHLSNTNNVETYKDSTSESEASSNDSYVDDEDEQIEVEDLISGEKKDMLSSSQ
RNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKC
VFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIIVERFEKAMNIKHC
ALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPVELQNLNPVTQLYLSIDAPNKEA
LKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEINSYINLIELGYPD
FIEIKAVTYCGSSQGYQLTMKNIPWHEEVYQFAWNLINKKKSLSDIYEISCEHKHSCSIL
IAKKIFKINNKWNTWIDYEKFQQLIKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRV
YTKGKYKNKNQPS
>B3T510|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine crenarchaeote HF4000_ANIW137N18|TrEMBL
MSCSGEVIEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEDIITKLMAERKKLIM
GHYGDPNQDKKKLDESLLPSHYSISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYKSFLKINRPRYDDSWERWNRTLKMLSTLGTRTVL
RITLIRGYNDDEEMIPAFASLLRQSNTHFVEIKSYMHIGRSTNRLEHSDMLEMSEVRSFA
NKLAQENSAFTVMDESEISRIVILQNKKRFVDRFIPACC
>C4YSR9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida albicans (strain WO-1)|TrEMBL
MGFGQILLFACSILYLSTGGRWTVVALVFVLYILYNKDQQQQQQPPQPQQQQQQQQQQQQ
QQQLKPSVPPLAKPKKESPIYAVDFTFSSKAFTPSTTTTFPIRRVIAPRPKRSPKIFTAS
KPIVQQQQQQQQQRQPVLTKTTVELKKCQIYIFYTTLTGSSQRIAKSLYEKLQNLENLEL
EPKLLSLDDDVDDLEEYFLNVPTQNDNNCIYLLVLPSYETDSPIDYFLEHLIDTAQDFRI
DKYPLRKLIGFSVLGLGDSESWSHDNKFCYQAKLADKWLGKLGARRLYPLGEICMKYEGE
PKAQEWIQNFASLIVNNDNEPFYIDDNNNDDDIDDSDAEESEGSDDADTLVDVEDMGDII
RKSGKTTTIGGGGIETKEMVAKDSPTFKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSC
YKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEKVMAGALEGH
YQKIKQLRGVPGIQMDRFEEAFKVRHCALSLVGEPIFYPYINEFVGMLHEQHISSFLVCN
AQHPDSLAKLTKVTQLYVSIDAPTKKDLKKVDRPLNSDFWERLMSCLDILRTIQSHQRTV
FRLTLVKGFNMEDIESYADMVERAKPSQIEIKGATFCGSSNGNGNPLTMQNIPFYEECKN
FVENLNKELQSRGLDYDIAAEHAHSCCILVADKKFMINGKWHTHIDYPKFFELLESGKEF
VDLDYVKETPEWAVWGSQGAGFNPEDTKYDRKAEKLKKKAIRDEQAKKLVEQQQQQQQQE
TVQAKR
>A0A497FPT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MEHTEKLKTMWSLDNLRLIYSRMGYHFTGIQAVVKPCHWLKESLLSGGLKFCYKQLWYGI
PSHRCLQMSPVIVCNYQCLYCWRVHEADLKIPPLTPDKYSYLPYDPPERIVEGSLEAWRN
ILSGFKGNPLVDEELLREAFKPIHVTLSLTGEPTLYPFINEIIKEYFQRGFKSVFLVTNG
SRPEVLRNLKPLPSQLYVTLPAPDKRTFTMVTRPLQGGSWNRILETLRLLKEIKCPTVVR
LTMVKGLNMISPEGYARLIRKAEPTYVEVKAAMSVGYFRRRLSRECMPRHSDIVKFAQKL
ASYLREDGYKIIGEYLPSRVVLISKIPEPLKIIE
>A0A497G3I8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MEGFNAYLKLMHDTYKRQGYHFVGVQAVVKPCHWTKKSLISGGREFCYKQKFYGIPSHRC
LQMSPIIQCSQRCLYCWRAQPSDLKISFDELKVKVYDDPYSIVENSVSEWQKILSGYYGN
HKIDPVMLQEAMRPIHAAISLVGEPTMYPRISELIEAFFEYGFKTTFIVTNGNFPEVISS
LEREPSQLYLSLSAPDEETYRKVCRPLLKDGWRRVLESLELLKSLSCPTVVRITLVKGLN
TSNIEKYAKLLADAEPTYIEPKAAMSLGYFRHRLDVNSMPRHQEVREFAEKLAEYSGYNI
IDESLSSRIVLLSKLRKPIKLI
>A0A842TQZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MIPEKVKKILKKQQYRIVGEKGHSAVQICRWTKNSIRDEGVCYKEKFYGIKSHRCCQMTP
AVMWCPNKCLHCWRAIELTLGDKLAEKAKEKLDSPKEIIDGCIKAQKKLLEGFKIKPETK
HKTVSKANMKKWLEAQEPMQFAISLSGEPTLYPMIGGLIKELRKRGKTSFLVSNGLYPEK
IKELAEKKQLPTQLYISVNTPNKKLYKGFHRSSKKDAWERLNKSLEIISKIKGQNEGRKT
RTVFRMNLIKDLNMEDKMILEYANLIKKAKPMFIELKGYMSVGFARQRLGYERMPDYNEM
IDFAKKLEKQLQKMKLDYKILDKHEHSRAIVLGKNKKDLKIKSY
>A0A2D6RNB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MKINDQIRKQLQKEGYRIVGNHSAVKICRWTKKSLRNEGECYKSKFYGIDTNRCCQISCS
LLNCQNKCIHCWRDLEYSYTSEIKNPDSANSIINGCIKAQRKLLEGFKILPETKHKTLSK
VNMKKYEEAQEPTQFAISLTGEGTLYPKIGELISELRKRKKTSFLVTNGLFPEKIKELKK
KKQLPTQIYVSVNASNEKLYNKFHRSSIKNAWKKLNETLEIFSKLYKKTRTVFRMNLVRN
LNMEDKHIKEYAELIKKANPLFLEIKGYMAVGHARERLEYNRMPTYDEMKEFSKKLAKEV
DLKILDEHEFSRVFVLGKNKKDLKIKRNEI
>H2UW46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
MQGSSRVLFSLSNLTSFVTMFCVFAIVFLLIHHAFSSDSKEQQKSHISADYFMAIWHNRL
YLYSTAALIFGIWFSLKMAIKKKNQDSNANSLAYKPVKKNDKDSMVHVSGVKIFYGSQTG
TAKGFAKELSDEIKALGIPAVVLDMKDYDPDDELAVECTNKSVCVFLVATYTDGQPTENA
EWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIM
TRAEGDCNVVKSRNGSVQADFLAWKVKLLKRLQALARGEKKICSGNCKTEGKCKNKRKVK
GEENAALQNNSSEGELIESSSDEEESGLQEEKQSGTMLDMEDLGNIMNLVNKTKSNENGR
GKGQTVKLSKLNGLKKTEEEEDVREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDA
LEKHQNMIRQFRGVPGVKLERYEEGLEVKHCALSLVGEPIMYPEINTFVRLLHTHNISSF
LVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDYWPRFLDSLRALGEKRQR
TVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVA
FVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVGVYEKTGGQR
SFSALDYMAKTPNWAVFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A4U5UZ84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Collichthys lucidus|TrEMBL
MLSLLVAVLLLTGRVSASDSKGSHTVNNPSRSFFLSVWHNRLYLYSAAALFFGIWFSLKV
ALKKKSFSKDVGSLVFKAVKNNDRDPVVHVSGVKIFYGSQTGTAKGFAKELSEEVMTLGL
PAEVIDMKDYDPDDQLADECTNQSVCVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGK
TYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRHGSVQ
ADFLTWKGKFMSRLQALTKGEKKSCSGNCKSGGSCKNKKRGGHEETQEETAPQNNSSEDE
LIETSSDEESGLQEEKRSGSVVDVEDLGNIMNSAKKAKSREDGRDQMVKLSKMNGLKKTE
DEVERREMITPALSEALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEEALEKHQNLIRQFRGVPGVK
PERYKEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVPVT
QLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLKALGEKRQRTVYRLTLVKAWNVEEMQA
YSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVSFVQQLADMLPQYEIACEH
EHSNCLLIAHTKFKTDGEWWTWIDYERFQELVQLHEESGGQRSFSALDYAAKTPSWALFG
AHEQGFDPADTRFQRRNKTKDVSGC
>A0A1Q9NHS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Heimdallarchaeota archaeon LC_3|TrEMBL
MSQFDLQVSGNMLEKMQKQQYRFVGNYNHTAVKTCGWTKNMIRGEGGCYKLKFYGIMSHQ
CLQMTPSISCANRCSFCWRDDKAKVSKDWVWGIDDPIQLVEEACQAHHKLLNGFKGNPKA
NKSAYKQSNEIKHVALSLTGEPITYPRLNEMVDEYHKQGISTFLVTNATYPEHINNLHPV
TQLYISLDAPNKKLLKDIDKPVFEDYWERLFQSLDYMAQKKYRTTIRLTMIKELNMIESE
NYSKLIRKGNPDFIEIKAYMWIGASQKRLTRENMPLHEEVVEFSKDLIKFLPEYEICSEH
IPSRVVMLAKKVFKQNNIWHTWIDFPKFLELSNKGLEIVTTNFLKRTPTTGLSGKGTLNH
RKKKDEDVVYIDLISDEVKVDESTPELEFYFKQEDPSADGC
>A0A8H4HKJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neosartorya fumigata|TrEMBL
MAEHSTAEGLLVFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSRESSNKATAQKAEQQPALANGSAKPTSGPKRVTGKKPSKVAGRRGQTEDAEPL
NFIQPIIFYASLTGNTERYAKVLLDELRVAAQKRADLRDRERGLLPPQIYDLSYVDLDDY
FTSAPKPPPTSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAETSLKEWSLGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDLLHGEHISSFLVC
NAQHPDQLQALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYADLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEREK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A5E4JSJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MISKKLKESLLKQHYRIVGKHSSVKICEWTKKSLINKGVCFKEKFYGIKSHRCCQMSPST
VFCQNKCLHCWRAIELTDGKKMDSKIIDNPKEIINGCIEAQRKLLI
>A0A8C2ALF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKGFAKELAGDVIAQGIQCEVMDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTES
AEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARI
MTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKSASCKNKKKHK
EEAEDSQSHAEKNNSEEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKRMEG
DEEDSQRVKLSKQNGVRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQ
EAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNIS
SFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQ
QRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEV
IYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGG
TKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A8C1PUW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYN
TVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQALAKGEKK
ACSGKCKKGSCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSDAESSAEEEKSHGSVIDM
EDLGNVMNRMKKAKVKTKPCSSTSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWSWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCAL
SLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEV
KGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKV
DGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQR
KNKTKDISGC
>A0A7C4GTE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MVAVRTSIDQIERLRKSGYRIVGRHSAVKICHWTKNVLRGGKHCYKSWYGVQSHRCLQMT
PSLQYCNMMCIFCWRFHTINRVTVYEGEWDRPEEIFDKLILEQRQLLSGFKGNPAVDKKL
FKDALEPNNVAISLDGEPTLYPYLAELIKIAHKNGMTTFLVTNGTTPRKLEELIEKDAQP
TNLYISLYGPDYATHVRTCRPLISDSWTRLMESLKLMPSFGKSRKMIRLTLVKEYNMRDP
EKYAELIRNAKPDYVECKAYMHVGESQKRLPKEAMPSMNDIIDFSEKLSLLIGYKIISHD
NASRVSLLANESSPYYSLDYNRIFR
>G0HSD1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula hispanica (strain ATCC 33960 / DSM 4426 / JCM 8911 / NBRC 102182 / NCIMB 2187 / VKM B-1755)|TrEMBL
MKPTAMSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQ
MTPVVKCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPRE
VFDQAMEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLY
VSVDAADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYA
AMCDRADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDS
RVAMLAEDENTWVPKLEKSSEFWEQDSLVEY
>A0A8E5HWD8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ustilaginoidea virens|TrEMBL
MDPLSGISDVGTRALFDDIVGVWHEYRTPLILSALVFLLAVRVYIRKTTEPNPSETIRNA
AEKKLASSSALVAREWNAIVAEKRGAKPDGPRRIKGGVSGKPIVQEKEHRHDRDRPVKVL
VFFSSVTTKTEKIAQQYLTRLQSSNADMSKAAERQLLTPELHDLADVDFEDFFVNPAKSP
ENAQLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLAPLLGYSVFGFGDKEGWPD
EAEGYCFQAKELDKWMSKLTSGKRAYPVGMGDMKSDHVERFEEWARGVQDAIASVARNGS
LGEGAPGSGDALESDVEDNAEEEYGEAAARQEGKTSAAAEEPSRPLDDMEDLGRMLQTSS
SKEIAAGKKAPLAVDFTSYASSAKKRPQPAPVVKEMVAKDSPTYAALTKQGYSIVGSHSG
VKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRW
VVDPPDMIFKGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEF
LAMLHSERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKDSLRKIDRPLHRDFWERFQ
RCLDILRAKRFRHRTVFRLTLVKGFNVDDQVEGYARLVERGLPCFVEVKGVTYCGTSTSS
NAGLSMSNVPFYWEVCDFVRALEKRLKDKGLRYGIAAEHAHSCCILLASERFFVRGKWHT
HIDYQRFFELLEERGPDGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGNRIENVVV
REAPPREI
>A0A842WNZ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Lokiarchaeota archaeon|TrEMBL
MPPQLRDKLKTQGYHLLGNRGAFKACQWQKRSLLDGDTCYKQRFYGIQSHRCLQMTPVVD
KCTQDCRFCWRVTPSDIKTNWDQTHLKKEDVLPPEELLKLVYRANLQSLGGYNPEAGARV
ELEKYKEARNPRHVAISLSGEPTLYPFLGEFIERIKEKGMTSFLVSNGTQPKVLAEIPPP
TQLYITLAAPDEETYGKLCRPLIRHGWDSLNESQEILATINTRTVNRLTMVEGLNMHNPK
AYAEMILKGNPDFVEVKGYMFLGASRDRLSHRNAPSHRTIQSFSEKLADFTGYHVLDEQI
ESRVVLLSRKKKIEKLKGGE
>A0A523B8F5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nezhaarchaeota archaeon WYZ-LMO7|TrEMBL
MIRNLGEHKMLSQSTALTIMDLLRQQKYQLIGSRKTAAVKKCYWLHMALTSNRFCYKNWY
GIESHRCIQMTPTLACPNSCLHCWRIERGDPNTSPWKEEDFITHDDEKAIFEQAIRAQFR
ILSGYKSNPKVIKERYVEALHPRHFAISLAGEPTLYNRLGEFIELCRSKGFTTFLVTNGM
YPEKLASLIDKGRPSQLYISVNASSDEKFMALSRCSLIDGWQRLMRSLRLLREFKCPTVI
RITVIRGVNDHENDIESFAKLISLAEPWYVEVKGFMYLGYSRFRLELSNMPKHRDVLSFA
EKLSKVCGYNLVAESLASRVALLSRISEPVKVHP
>S8AKE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dactylellina haptotyla (strain CBS 200.50)|TrEMBL
MAAMASSKSLDLLELWHTIRIPAIAAVAGIYLVVALRNRHFTQRETYDGPPSPSKLEPQL
SAEPDGTVLLPEKFEDTSTSNRSRNLPASSKSGPKRITGGEVRKKKVNGPNAEGSTPIEQ
AELDANQKAIQIFVFYSSLTGSTGKYAEQFAKELFSKPLHKPSPAPPIANGTDIPPESNE
KAIFLSPIVENLDYLDLDDYFISPASVKRKNTTSVYLLLIPTYEITSPVDAFLEHLSETH
HDFRIDTRPLSSLAGFSVFGFGDKEGWPMEEGRGGGIFCGQAKEADRWMSKLTGGKRIFP
IGMGDVKGDATASLTEWREHLEIALHDLANGDAISEDNGVDSEDEEDTAQDNAANTTETL
VDVEDIGNSIRSSNPPKTKKSQGPLPVDFTTTSKRSAPKVKEMVPKDSPTYTALTKQGYT
IVGSHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNP
VSTTWNWTVDEPDLILQGAMEGHYKKIKMMKGVPGIRADRFAEAFTIRHCALSLVGEPIF
YPHINEFLSMLHERRISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKESLRRIDRPLHR
DFWERFMKCLEILRAKRDRMRTVFRLTLVKGFNIEDEVEGYADLVEKGLPAFVEIKGVTY
CGTSTSVGAGLSMQNVPFYEEVCEFVRRLNEALEKRGLGYGIAAEHAHSCCVLIASNNYY
IDGKWHTVIDYKRFFELLEEGKEFGPLDYVGPPTAEWAVWGNGGFDPADQRVYRKGKNKG
KVIEEAPSGEAESGCG
>A0A428SSX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sp. AF-4|TrEMBL
MDWANYSAPSRLDSFVEELVDVWHIHRTPILVAALVVLGTLRIYLTFIGRKTELVALTEA
YKEPPKPKAVVEAKTPAVETIDEKKDNLTRPIMVLIFFSSITTKTDKIAQAYLKELEVKQ
EELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKMHGDVDYFYTFLIPSYNIDTINDTFLE
HLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPTEGEGFCFQAKEVDKWMAKLTSRKRA
YPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGNLGEGLPGSGAAEESDVEDIAEDEDD
GEVLFEDDDTSDPKKKNGRPLDDVEDLGRMIRKDDGSTKMVPQGPKEMVAKNSPTYAALT
KQGYAIVGSHSGVKTCRWTKSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWR
HGTNPVGTTWRWVVDPPDLIFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLV
GEPIFYPHINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKID
QILREKRNRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAG
LSMSNVPFYWEVCEFVKALEKRLKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRID
YKKFFDLLEERGPDGDWTPEDYMDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A4T0X3T8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] inconspicua|TrEMBL
MTDIIAAVSAILLFLALGGKLALIFLLLSLAGLIYFSPTPTPIKADAIGKIQTRSRKGIK
TKVITPDIQKLKRAIPETDLYTANKVSLKESPIYIFYSSLTGSSKRIATQLSTTLVNSGH
DIKKDNLRLLSLDDDIDDLDNYFLNTPKDKTPPIYILVLPSYESDSPIDYFLEFLEDTAT
DFRIDKYPLKALSGFAVLGLGDSESWSELFCYQAKLADKWLSKLGARRLFPLGRLCVKND
INTTSEHYITRLINVISDNEPILYEENDPEATDDESDGGEYDSDVVSDEGTLVDMEDLSK
SDKAKTDSNLLLKSTMKKQMVAANSPTYKSLNKQGYTVVGSHSGVKICRWTKSALRGRGF
CYKFAFYGINSHRCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWEVDKPDLILNGALEGH
YKKIKQMRGVPGILMDRFEEAFTVKHCALSLVGEPIFYPYINEFLQMLHEKEISSFLVCN
AQHPDQLKTLGKVTQLYVSIDAPTKEELKTVDRPLFRDFWERLEQCLDILRTIQSHQRTV
FRLTLVKGFNMSEADIGGYANLVERGLPALIEIKGATFCGSSEGNGNPLTMQNIPFYEEC
VSFVKKLDIELNNRGLAYGLASEHSHSCCFLIASKNFYIENKWHTHIDYTKFFELLKSGK
KFDKMEYIAPTPEWAYFGSDQGGFNPADTRWNRKEEKLKKKMERESQSQSNDVTVNQ
>O27118|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)|TrEMBL
MAMYLEESQRKMERMGYRFVGEHGHSAVKTCLWTKKSIVNEGVCYKEKFYGIRSHRCLQM
SPSVPFCQQKCLFCWRDLSSTGTAWEGPHDEPADIIDGAIEAQRKLLCGYLGNERADKIK
VMESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLSEEPTQL
YISLDAPDRDTYKELCRPQIPGAWDLLNSSLELMPSFSCRKVLRITAVRHINMKDPEGFA
RMIERARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDESRESR
VVLLA
>A0A2H9QGX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon CG_4_10_14_0_2_um_filter_Archaea_38_6|TrEMBL
MNREVYTKKRYNLVGKHSAVKLCNWTRRSLTGKGECYKEKFYNIKSHRCLQMTPAVAWCE
HSCLFCWRPTEFTSGTSMENVELDEPEIIVEKAVEAQRKLLSGFKGNPKTPKKIFEEAVN
PNQAAISLAGEPTLYPKINGLIREFHKRGFTTFLVTNGMNPEVLDKLKPLPTQLYLTIPA
GNEEDYLKITRSAFGKKGWDNLMKSLKIMKKLETRRVIRLTLVKGLNLKNPEEYAELVRK
ANPDFVEAKAYMHVGSSRQRLEEFHMPSLSEIRQFSQRLAQILGWKIIDEHETSRVCLIA
KEDYNWRFL
>A0A7N2QYC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Quercus lobata|TrEMBL
MSLSSFSARLTLLALLSASTFYCFYESRRLRKLKLSLQNPNPNRSVSKPKLFFVSQTGTS
KALAQRLFDLLAINDLAFDLVDPKDYEPEDLPKETLVLIVASTWEDGKAPASAKFFANWL
AESADDFRVGSLLLSNCNFAVFGVGSGAYGATFNSVARDFSKQMRAMGAREVLPVWEGDV
DSGDVDEVFDAWSVKVVGFLKRGGVVENGGGEVLVSESDGEDEDSEEEGGDEGSDIVDVE
DIAGKAPLRKKTVTVAETNGKLNGKKDMVTPAIRASLEKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVN
SAIDLHTNMIKQMKGVPGVTLERLMEGLSPRHCALSLVGEPIMYPEINTLVDELHRRQIS
TFLVTNAQFPEKIEMLRPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALREKQ
QRTVYRLTLVKGWNTEDIDAYSKLFSVGKPDFVEIKGVTYCGTSATSKLTMENVPWHSDV
KAFSEALALRSQGEYEVACEHVHSCCVLLAKIDKFKVNGKWFTWIDYEKFHNLVASRKPF
SSVDYMAATPSWAVYGAEEGGFDPGQSRYKKERRHKSSTD
>W4GWA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAKPVAVRILYGTHTGTAKGFATTLQQKLFALNVAGYAFEPSVVDMKD
YDQDNLEHEHVLISILSTWTGGVPPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLG
NSEYDEHYGKASKALSKHLSSLGASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGA
LRSPAASSSSSPSVKPKQQPAGWKSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIV
LELDQGDDSDDEDNRPKKPDSGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYK
IIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNP
VGREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIM
YPHINEFCRELHAREISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFK
DFWERFLSCLTQLKAKGQRTVLSFLYPRYGLLCWFAISID
>A0A7J3XY71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermogladius calderae|TrEMBL
MLRGIDWSEVKRKREEFWNSNPAYKAIYERMVKQGYHFIGTIGVVKRCHWSKEAVLRNRF
CYKCLWYGIESHRCIQMSPVAAWCWNRCLHCWRIQPEDIGLHWDETRVPVVDDPEVLVEE
SIKVHREIMAGFKGNPKADQRRVEEALNPKHAAISLTGEPLLYPRLGELIKEYHKRGITT
FLVTHGTRPDVLAGLEEEPSQLYISIESWDKKSYEEFNRPLVPRAWELFQETLELVRSFK
SPTVFRFTIVKGYNDHEEALKSFAKMVEKGNPTYVEVKAYMFLGGSRGRLTLANMPEHED
IRRVARRLSELTGYMLLSESVPSRIVLLSRIEKPIRHGKGCPDGVEHPEKWCPVLTREYE
ERED
>A0A1D1VX72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ramazzottius varieornatus|TrEMBL
MDSVVIDYLTLFVFTTAFGYFVQRYLKKRIQAEIAKGATQAQLAVSAASQITNNEANDGS
RAKTVKAKKRDVKKPASTSQMEQVRDSLPSVPDSVNAGSCACGSKPDDGCCKTAIPDERS
GVDFKSIKIYYGSQTGTAKGFASLLEKELCATAKVESIEVSDIANWDPELFVSKLSPDCL
HVFILSTWTDGTPPSSARWFSLWTNDAVDDFRVSKTFLKDLRFAVFGLGNSVYDHYNKVA
KTIFKQLGSLSAHPILPLGLGDEEVSNSKHGGLRADFAKWTEDLKQALASKEDVPQHVIE
QENEDLEQVSDDGESSGMYETTSEEGDSGEGLRSDTENVMDVEDLGIVADKISSAKKDTV
PKHDRVRSKRKDGSGDAPQLKEMATPELKAALQKQGYKIIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTSWKWQMDEPEKIVTDAVDY
HVQMIKQFKGVPGVKSERFLEGLSPQHCALSLVGEPIMYPEINKLISLLHARQMSTYLVT
NAQFPDAIRTLSPVTQLYVSVDASNKESLKKIDRPLFRDFWERFNDSLLALSEKGQRTVY
RLTLVKMFNVTEIEAYANLVSLGKPDFIEIKGVTYCGDAVGGLTMENVPWHEEVVSFVSQ
MANLLPDYELASEHEHSNCILLANKRFKVDGEWWTWIDYPKFQELVRQYELSGGEKTFTS
ADYMAKTPHWAVYGCKERGFDPQEVRFHRKNKKDISGC
>A0A3P8QDF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astatotilapia calliptera|TrEMBL
MPTFIVFVLLLASSVSASDSKVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKK
KSVSKDASKEKNDKVDKAAKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKSLG
LPAEVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSI
QADFLTWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKASPQNNSSEDD
LVESSSDEDESGLPDEKKTVLDVEDLGNIMNSVKKAKSKEESQRDGQMVKLSKLNGVQKI
EDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGV
KPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPV
TQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQ
AYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACE
HEHSNCLLIAHTKFKMDGEWWTWIDYERFQELIQAYDESGGQQTFSALDYVAKTPSWALF
GAQEQGFDPAETRFQRRNKSKDISGC
>A0A7S3FR01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chloropicon roscoffensis|TrEMBL
GGSSFVSRILRLWKSLLRLLKDLVASSKTCQNLSLWLGLPSVKEVVSFARGERGRNGSRD
ITTGKVLYGTQKGNSRRLAHKLAHLAKVNFGLELEVLSLDGYEVEKLPEERGLVFFVVST
YTDGTPPDAAKWFFRWVEESAHDFRCGADFLKDLKFAVFGCGNSQYSRNFNTCAKDLSEK
LRLMGAEEVAEVFLGDEDKGSLDTQLVDWTGLLRLRLQDYCRPLDPAQAAVAAAGAHGSK
RKSDKVKAKLERIRAEKLSASGQSTDIEDIGAKDLNEVEGGEKPEMLNHTVRGNLKKQGY
KIIGTHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTN
PIGKEWKWKMDPPEDIVTGAIQYHRGMIKEMRGVPGVKPERIAEGIAVKHCALSLVGEPI
MYPKINELCNRLHGEGISTFLVTNAQFPDAIEKLVPVTQLYVSVDAGNKESLKAIDRPLF
SDFWERFLLCLQKLRDKRQRTVYRLTLVNDWNVEEVEQYASLVDIGKPDFIEIKGVTYCG
TNDASSLTIKSVPYHHEVRAFGEKLCALKEDYGLACEHEHSLSILLARKDRFLKGDKWHT
WIDYDKFQSLCRSGKTFGAEDYMVETPSWAIWGAEEKGFDPNETRFRKKRNHPGKAASVA
HQNGHGQEESALAIKASN
>H6BKG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala dermatitidis (strain ATCC 34100 / CBS 525.76 / NIH/UT8656)|TrEMBL
MDLGEGGAAPVILADWLDRSLTVWHDHRVVVTALVVLSILTLWVRRRRRLAQARPSSPAL
EKADPSSSTTTTTTTSEKANPAKSSNNDTATAFTRTASPSKKPDQGRKSTRPTAARVVTG
RKPTGTKAGARGLKAERAILQREQAEPCQIQPLVFFTSLTGTTERLAKDVVAALEAFSES
EVQSQTVLKPQVHDLSYIDLDDYFITGPKSPVPQANIRYFYLLLLPSYDIDTILNTFLAH
LDETHNDFRIDTSPLSTLAGYTVFGVGDKEGWPDENRGFCAQAIEVDRWMAKLTGRKRAY
PLGLGDVKRNLDGALKDWLAGVRNVLEELAATGNLGEGVRGSGDALESADEEEEDEIDDV
DDDTAEVQVQEEVDFPDSGRNKRRKIAATSTVDLEDVGGKGTASTLAVDFTTYSPAAGTQ
SSGVLKAMVPKESPTHAALTKQGYTIVGTHSGVKICRWTKSALRGRGSCYKNSFYGIASH
LCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPVEIFNGAKEGHYKKIKMMRGVPG
VRSERFAEAMRIRHCALSLVGEPIFYPRINEFVGLLHSEHISSFLVCNAQHPQQLRDLHR
VTQLYVSIDASNRDSLRKIDRPLHRDFWERFQACLDILREKRFVQRTVFRLTLVKGFNVD
DEVEGYADLVARGLPCFIEVKGVTYCGTSVSANAGLTMGNVPFYDEVVEFVNALDRALAK
RGLEYGIAAEHAHSCCVLLASNRFRINGKWHTVIDYDRFFELLDKGVDFRPEDYCKETAE
WALWGNGGFDPRDVRVDRKGRPKE
>A0A7J6UI75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus olseni|TrEMBL
MLAGGFYRALLSKHYSGPSRTVKVVYSSRTGTSKAAAGRLKDTLESDKIRAILLPVEQYS
YEELCEESYLVLLLSTDTDGTPLPGAKGFTEQLRDAVYDFRVDKNLLEKCKVAVIGFGSE
EYPAKHYCKVAKNCDDWLAKLGAQRVSPLLCISDTRDVEKQVGRCIDLIRKAYARLDAEP
TDQRTADLEDDVESVGSEESTSDTEDGDVEDASGACGSSSNKEMVTKKHRAALTREGYRL
VGSHSAVKLCRWTKHQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPV
GRSWTWAQDPPEEIVDGWLGNHAGMIKELRGVPGVTPERFEQAKRVRHCALSLVGEPIIY
PQINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAKDMKAIDRPLFED
FWDRFIDSLTALKHKKQRTV
>A0A5N5HRF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrus ussuriensis x Pyrus communis|TrEMBL
MSLSSTPARLTLLALLSATTVYCFYKSRRLRRLKLSLNPNSSSSPRRGKLFFVSQTGTSE
ALARRLLDFLKLKGVAFDLVDPNNYEPEDLPKETLVLIVASTWDDGKPPPNAKFFSDWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDLARRMRALGASEMFPIWEGDVD
GGDLDEVFDAWSGKVVRFLKGGAAENGGVLGNGVSDECEAESFDVSDEEDEEEEDGGESG
VVDLEDIAGKGPSRRNPVAATKTNGTVNGKKEMVTPVIRASLTKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
LEIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALIDELH
RRRISTFLVTNAQFPEKIKMLNPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLTS
LKDKQQRTVYRLTLVKGWNTEDIDAYYNIFSLGSPDFVEIKGVTYCGTSATSKLTMENVP
WHADVKAFSEALALKSNGDYEVACEHVHSCCVLLAKTSKFKINGQWFTWIDYEKFHDLVA
SGKPFDSKDYMAPTPSWAVYGADEGGFDPYQSRYKKERHHRPNQ
>A0A497QG20|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPSKLRERLQRQGYHLLGERGAFKACQWQHKSLLEGKVCYKQRFYGIKSHRCVQMTPVVD
KCTHQCRFCWRVTPADVGVLWNQTEVGESDVLGPRELLDATLMANLRSLGGYNPEAGAPV
PLEKYLEARDPKHVAISLAGEPTLYPLLSEFIEEVHKRGMTSFLVTNGTMPRVLSRLTPP
TQLYVTLAAPDEETYRRVCRPMIKDGWARLKESQEILQSFSTRTANRLTMVYGYNMEKIR
KYASLILLGEPDYVEVKGYMYVGASRGRLERHNAPPHREIRAFAGKLAALTEYYVQDEQV
ESRVVLLTRSKQIEKIQTRRTE
>A0A4D9BCS7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salvia splendens|TrEMBL
MCAGFSIQEHCPKLTQWVKRCLEIDFMSESLADPAKGGKERRDNEKKKKGEEDMGIHGLR
VSGNETQAGRISDNRDQIDDNASHGSRAQRNEGSTGSLPKASVVGDATAGVKDHKKSWRD
ILLVDAIYILMFGMRARIALAAKGVVYEYREQDLRNKSQLLLQSNPIHKQIPVLMRRAQA
RFWAHYIDKQLYGAGRKIWSTGSGEEQEAAKKELVESLKQMESQLGEEAFFGGERLGIQE
HCPKLTQWVKRCLEIDFVSESLADPAKIYDLMVEMADDLPCCDTKFFLYVIVIIGLVLFA
GMMAGLTLGLMSLGLVDLESLPIFLDKLVPPWAAILVSVTLILMFGEILPQAICTRYGLT
AGATAAPFVQLLLWVFFPIAYPISKILDWMLGKGHAALLRRAELKTFVDFHGNEAGKGGD
LTHDETTIIAGALELTAKTAKDAMTPIAKAFSIDLDGTLNLETLNAIMTMGHSRVPVYYN
NQNNIIGLILVKNLLAVDPDDSVPLRKMLIRKIPRVSEDMPLYDILNEFQKGHSHIAVVY
RDSKDTLQKTKEENHIFAIKTVTHDADSVMNKSDDQVKKSPPATPAFKKRHKGCSFCILD
LETSPIPEFPPDQEVVGVISMEDVIEELLQEEILDETDEYVNIHNRIKINMNAASQDKTP
DSNSIQSTTPTNTSKALAQRLHALLTLSDVPFDLVDPKDYEPEDLCKETLVLVVASTWEN
GGPPQDAAFLVNWLAESAEDFRVGALVLKECRFAVFGVGSGSYGETFNAVARDVAAKLRK
LGGRELVELGEGDVDLGDLNGVFDRWSQKIVGVLNGNIEENEQGLGNYVAGSESEGEYSE
EDDEDVEESDVVDLEDIAGKGPSRRSAVEAKANGKVNGHASNGEKEMVTPVIRANLEKQG
YKVIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWQWKMDDPLVIIDTAIDLHKKMIKQMKGVPGVKAELLAEGLSPRHCALSLVGEP
IMYPEINNLVDELHRRHISTFLVTNAQFPEKIMALKPITQLYVSVDAATKDSLKAIDRPL
FSDFWERFLDSLKALKEKQQRTVYRLTLVKGWNTEDIDAYSSLFDVGNPDFIEIKGVTYC
GSSATSKLTMENVPWHKDVKEFSEAIARKSNGAYEVACEHVHSCCVLLAKFDKFKVNGQW
HTWIDYEKFHNLVLTGEPFTSNDYMVPTPSWAVYGAEEGGFDPKQSRYRKERHHKSAR
>A0A7K6RUE4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhynochetos jubatus|TrEMBL
LDIPMDTWSFFSTCLVSVWLHRFYIYSAIAFGISIWLIVQFTPTKTRKKVTEPGEKSNGN
PASSEGIEDKLVNGSATLQAKEVYVAGVKIFYGSQTGTAKRFARGLAEAITSLNLPVEVI
SMGDYDPDDCLAEETASRNVCVFLVATYTDGQPTESAAWFCKWLEEAVNDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WKAKFLSRLQALCRGEKPCSGKCKKGKCKSPGKQSKERTDHEHGASEYVNTEAEELFETS
SEEEADAEEAGGTNSVIDVEDLGNVMSHMKKAKEGDVGMSLTRENAGRKEEGEKREMITP
SLREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFRGVSGVKADRFEEAMTAK
HCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTK
ESLKRIDRPLFRDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVALGKPD
FIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHK
KFKVNGEWCTWINYGRFQELVQEHERSGGSKTFTAADYAARTPRWALFGSRERGFDPLDI
RYQRKNKVRDISGC
>A0A830F0N4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halarchaeum grantii|TrEMBL
MPEQVDSPSYHHENHTAAQTCGWTANALRGEGTCYKHAWYGIRSHRCIQMTPVVRCNERC
VFCWRDHNGHAYELDGVEWDDPEAVVDASIDLQKRLLSGFGGNENVPRERFEEAMEPKHV
AISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEVLAECDPTQLYVSVDAPERHTF
DSVVGATEDDAWESLVDTLDVLHGKEETRTVLRTTLVNGENMTNPDWYAGLYRRADPDFV
ELKAYMHVGHSRGRLDRDSMPSPETVESFAARVQEHMPEHPVLKTQEASSVALLARDEET
WVPDLAPGGDFYD
>A0A7L2KKS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zosterops hypoxanthus|TrEMBL
LDVSMDSWSYFHACLVSIWLHRFYIYSAVAFGISLWAVVQFTTARTQKKVTEPGTADKLG
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYDPEDGLV
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTRLQGL
CKGEKKPCSGKCKKGKCKSSGKHSKESSDHEHGTSEHENTEAEEFFETSSEEEAGGTDSV
IDVEDLGTIMGHMKKAKVLLLEGSIGSMASVTLGTTWYIFVYQFLQTKLNCLMICALFSG
YKLIGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYC
GESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRT
WIDYRRFQELVREYEQSGGSRTFTAAEYTARTPSWALFGARERGFDPSDVRFQRKNKARD
ISGC
>A0A2Y9PKP4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Delphinapterus leucas|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKF
>A0A7C1IJC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MAAQPGDIRRIFEKQGYEVIGDHAAVKHCHWLRKSLLFNTPCYKQTFYGIESHRCLQMTP
AAYQCTQKCLFCWRYQGFTDTALSPAEAMDPDELLEGCVAAHQRLVSGFKGDQRCSPERW
EEARDPKHVACSLTGEPTLYPFLSDFFERCHRRGMTTFLVTNGTMPRVLATMDVLPTQLY
VSVCAPTKEIYRRLCCPLVPDGWERLMETLQLLPSLGTRTVIRHTLVDGWNLGHEREYAA
LDSRAEPWFVEPKGYVHVGYSRQRLTMDHMPSHADVRRFGEHLANHLGYRVLAERPRSRV
VLLGGGRERML
>A0A8I6XTV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hordeum vulgare subsp. vulgare|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRSPRPSPSPSSSPPAAATAP
TLLYASATGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDHVFEEWCGRVLRVVKGEEVEEEDGVNGEANGFDGMEGEESDYD
DFDDEDEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLE
KQGYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLV
GEPIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVD
RPLFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEVKGV
TYCGSSATSKLTMENVPWHADVKEFSEVLATKSGGVYELACEHVHSCCVLLAKVDKFKIN
GKWHTWIDYDRFNELVMSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAA
ALKG
>A0A060TI78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blastobotrys adeninivorans|TrEMBL
MPGWSPIFQLIFQSRIKIKLIISLLLKNIGKRWKMVLIELWYQYRVYLLVAAVLVLVYLG
RSSSSHQDNDIPTASTEKQASSEEKQRAVPLKNAKSKSFPTPVDFTSVSTKRAPKKFSSG
PKKFSAKKQSPNGASLDSRIIVLYSTLTGTSQRYAEKVHKYMCKISNNKTNPPELTNLDY
VDDLDKYFVSLDKDLNSAVLLLILPSYETESPLDYLIELLKETYNDFRIDSKPLAKLAGF
SVFGLGDLEGWPEEEGRYCYQAKLVDKYLGKLGARRIFPIGTACNKSDPDQKSLDQWLGH
LESTLSDPSSIAEEVDIADSDDEEEAENEDSGVVDVEDMGKIIKQSTTSPVDITTKEMVA
KDSPTFNALTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMETTPSLS
CSNKCVFCWRHGTNPVGTTWRWQVDPPEAIFNGALEGHYKKIKQMRGVPGVLADRFAEAF
QVRHCALSLVGEPIFYPHINEFVDLLHGQRISSFLVCNAQHPAQLEALKRVTQLYVSIDA
PTKESLRKVDRPLHRDFWERLEQCLDILRTKQSQRTVFRLTLVKDFNTDDLQGYADMVER
ARPAFIEIKGVTYCGTSKSNPLTMQNVPFYEEVKSFVEKLNETLNARGLDYGIAAEHAHS
CCILIAQKRFNIDGVWHTAINYDKFFDLLEAGADFGPMDYIAPTPEWAHYGNGGFNPEDT
RFIRKKASKKE
>A0A7D5SVP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon|TrEMBL
MKDDLKGILEKQQYKLTGGHAAVKLCHWMKESLLRGRSCYKQDFYGIRSHRCLQMTPAVN
DCTHNCLFCWRVRGFESSVNKWLEPEVMLDSLIEHQRKLVTGFKGDPRCSKQMWEESRDP
KQVAISLAGEPTMYPHLSDLIGLCHRRGMTTFLVTNGTFPKVLEEMDELPTQLYVTVAAP
NEEIYKRICVPRIPDGWSRLMQTLELLPSLSTRTVIRHTLVKDHNMGWEKEYAKLDVIAG
PTFVEPKGYVFVGDSRTRMSMDNMPSHNDILEFARRVGEEIGMVVLKDKKDSRVCVLGPP
GTDTRVPGLQ
>A0A1F6ZBW5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon RBG_13_33_26|TrEMBL
MIPENVKEILKKQHYAIVGKHSAVQVCRWTKKSLRDEGVCYKEKFYGIKSHLCCQMSPAV
MWCPNRCLHCWRAVEMTIDNELNGKIDSPKEIIDGCIEAQRRLLQGFNIDKNSKKKQLSR
ANQEKFSEAQEPMQFAISLSGEPTVYEKIGELIEELRKRGKTSFLVTNGLYPEKLEELEK
KKQLPTQLYISVNTSNEELYKKFHRSSKKDAWERLNKSLEIMTRLRNKTRTIFRMNLILD
MNMLPEHAEEYAELIKKTNPMFVEIKGVMSVGFARQRIPYNKMPYHKDIIEFSKKMLNFL
PEYKILDEKKESRVVLLGKDKADMKIKKGEI
>A0A842LHJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon|TrEMBL
MRSELLAILEKQQYKVFREHAAVKLCHWVRESLLRNRFCYKQEFYGIKSHRCLQMTPVVN
MCTQSCLFCWRVQGFESFPASWCDPEEMLDALIEQQRFLVSGFKGDKRCEINRWQEAREP
KHIAISLAGEPTLYPFLSEFIEVCHKRGLTTFLVTNGTKPEVLEKLDPLPTQLYVTVAAP
NEEIYRKLCVPKIPDGWERLMATLKLLPSLNTRTVIRHTLVQDWNLGWEEEYARLDEIAD
PTFIEPKGYVFVGQSRERMSLTNMPSHASIRDFGMRLGNLLGLEILKEKEDSRVVLLGEK
ERETIIPGVE
>A0A8C5TGD8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Malurus cyaneus samueli|TrEMBL
LDVSMDTSSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFATTRTKRKVTEPGPADKLG
NGCASPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVISLNLPVAVFNMGDCDPEDCLS
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRVDRWLWMLNASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLTRLQAL
CRGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGMSEHENTEAEELFETSSEEEAEGTNSV
IDVEDLGNIMGHMKKEKRELQEGAAGAGRKEEAERREMITPALRDALTKQGEALPRAVGA
QFGVGAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMD
QPELILQEALEKHQNMIRQFKGVSGVKAARLEEALRVKHCALSLVGEPIMYPQINRFVRL
LHQHDISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSL
KALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGDSAASSLSMAN
VPWHGEVLAFTQELARLLPDYGIACEHEHSNCLLLAHRKFQVEGEWRTWIDYGRFQELVR
ERERSGGARTFTAAEYTARTPPWALFGAAERGFDPSDVRFQRRNKARDISGC
>A0A7R9N0D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedenaceae archaeon GB37|TrEMBL
MVDEIQKLLKKHGYQRAGRHSAVKTCLWLKRSINNMGQCYKSRFYGIASHRCIQMTPTLQ
CNQRCLHCWRAIDAAIPETPWDSPEVIVDETLRAQERLVSGYGGSARAERSLWEESKNPR
HVAISLAGEPTLYPSLGELVNAFHRKGLTTFVVSNGTRPEAIDEIDPTQLYLSLTAPDRE
TYLRVCRPEREEMWEDLLESLEILSEKRTRTAIRVTLIEGVNDRDPRGYAALINRATPDY
IEIKAYMHLGFSRKRLERGAMPTHSKIKRFAQKIIEYTGYRWVDESEPSRVTLLSRDGKK
EKIEREDAN
>A0A0J8S2K6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides immitis H538.4|TrEMBL
MPDETFASGAQRALSLWHSYRGYALVLLPAVFILSHLIAARGKTAEASPPSIPSPPRSSK
AKQSRPTSGTEPPTSTTTPEEGTPSPNGAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDA
TKEISIQPIIFFSSLTGSTERSAKRVLERLNTEPLKDSKRSSRLLAPQLYDLSYVDFDDY
FVSPPKAPESNPNVLYFYCIIIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAV
FGFGDKEGWPTEEEGFCSQAKEVDKWMAKLTGRKRAYPLGLGDVKTDGDKALDEWCSGMQ
EVLCDMVTNNGALGEGVPGSGDPLESDEEDVEEDDEGVPNPGSRPRKARRAEITDLEDIK
FGGDASGKQGSDIPIDFTTYSKTSTSVATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWK
VDPPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFV
SMLHSEHISSFLVCNAQHPDQLAALDRITQLYVSIDASNRDSLRKIDRPLHRDFWERFQR
CLDIIREKTHVQRTVYRLTLVKGFNIDDEVVGYADLVERGLPCFVEIKGVTYCGTSTSAG
AGLTMQNVPFYEEVAAFAVALNDELNRRGLGYGIGAEHSHSCCILLASRRFHVDGKWHTK
INYERFFELLEREKAEGVSFTPEDYMSETDEWALWGNGGFDPNDQRVYRKGKNKANMSDA
GSVPKGGVVEI
>A0A7J9QLV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilaceae archaeon|TrEMBL
MSCSGETVEEDQLIQIKPRVAQQLKKAKYGVSDHSTVGLCHWTKKSFKHEGSCYKHKFYG
ISTHSCMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPENVAEPQEIMTKLMEERRKLIMG
HYGDSRSDKQRLDESLKPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEP
DMIQKLQDENALPTQLYLSTNAADYESFLKINKPKYDDSWQRWNKTLEMLKDLDTRTVLR
ITLIRDYNDQREMIPAFAKMLEESSPHFVEIKSYMHVGRSTNRLEHENMLEMDEVKKFSQ
EIVNQSKIFSVMDESYVSRIVILQNNQRSIDRWISSYQNTN
>A0A523AXP8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MQGSLQERLKRFEELYLKQGYRLVGRNSAVKICLWTKKSLLGKGECYKSKFYGISSWRCL
QFTPSLFHCTHQCLFCWRKVEATLEPHEELPPDDPGEVVEKAILAQRELLSGFKGNPKVN
LSKWEEAQLPKHAAISLAGEPTLYPLLTPLLEEFHRRGFTTFLVSNGTMPERLEKLGVEP
TQLYLTLPAPDETTYSRVCRPRIPNGWERLNLSLELLSSFSCRKVLRLTLVRGLNLKDPE
GYAKLVEKAGPDYVEPKGYFPVGYSRQRLGPALMPTHQEIRAFAEELERLTGYRIVDEVP
VSSVVLMKK
>D8J5Y0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halalkalicoccus jeotgali (strain DSM 18796 / CECT 7217 / JCM 14584 / KCTC 4019 / B3)|TrEMBL
MSGPKQVSSPEYHSENHTAAQTCGWTANALRGEGKCYKYAFYGIESHRCIQMTPVVKCNE
RCVFCWRDHRGHAYELGDVEWDDPEAVVDASIRLQKKLLSGFGGNDEVPREVFEGAMEPR
HVAISLDGEPTLYPYLPELIDAFHDRDITTFLVSNGTDPEMLARCEPTQLYVSVDAAERA
TFDQVVRAVDDDAWERLIDTMDVLAEKEDTRTVLRTTLVGGENMQDPDWYAAFYDRADPD
FVELKAYMHVGHSQGRLDRSAMPDHEDVVAFAEEVQEYMPEHEHLNDVPVSRVALLSKTE
ETWVPKLKKGSEFWERDPLAAD
>A0A7C4S641|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MIRNLGEHKMLSQSTALTIMDLLRQQKYQLIGSRKTAAVKKCYWLHMALTSNRFCYKNWY
GIESHRCIQMTPTLACPNSCLHCWRIERGDPNTSPWKEEDFITHDDEKAIFEQAIRAQFR
ILSGYKSNPKVIKERYVEALHPRHFAISLAGEPTLYNRLGEFIELCRSKGFTTFLVTNGM
YPEKLASLIDKGRPSQLYISVNASSDEKFMALSRCSLIDGWQRLMRSLRLLREFKCPTVI
RITVIRGVNDHENDIESFAKLISLAEPWYVEVKGFMYLGYSRFRLELSNMPKHRDVLSFA
EKLSKVCGYNLVAESLASRVALLSRISEPVKVHP
>A0A314ZMC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus euhalobius|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIDSHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A2W1FCB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora tritici-repentis|TrEMBL
MVFLQYAEQLPGELLLIWREHRLEILLSALIVATIARLVIYSRDRRREKLSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLPNVDNHAEDDTAAVRVVSKAKKGPKTVKGRKTQKKNT
APISTFDHKVHKIQPLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQIHDISY
IEHDDFFISPPKADANVKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GVQEALVEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSVVNSSS
APIPVDFTTYKKSAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINDLLSIMHSHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNARGLQYGIGAEHAHSCCVLLADKTRFQKNGKWATRIDFERDAR
VYRKGKGPKTEEGKIERELEGESKVQKAKALEF
>A0A2W1GFZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora tritici-repentis|TrEMBL
MVFLQYAEQLPGELLLIWREHRLEILLSALIVATIARLVIYSRDRRREKLSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLPNVDNHAEDDTAAVRVVSKAKKGPKTVKGRKTQKKNT
APISTFDHKVHKIQPLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQIHDISY
IEHDDFFISPPKADANVKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GVQEALVEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSVVNSSS
APIPVDFTTYKKSAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINDLLSIMHSHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNARGLQYGIGAEHAHSCCVLLADKTRFQKNGKWATRIDFERFFD
LWEGKMEGTRVEGGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKTEEGK
IERELEGESKVQKAKALEF
>A0A7J4GWD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPVLMAKLQKQRYHIVGEHGGVKICHWTKESLLRGRQCYKGKFYGISSHNCLQMSPVVD
QCNLACSYCWREPHMDALELSDQDPLEMLYDSVKAQRRLLSGFGGNDKVPKDKLLSAQTP
KHVAISLNGEPTLYTKLSEYMELCHAHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKQVFDEICRPKWNAGAWEKLEETIDLLPSLDTRIVCRHTLIKGRNMKEEHIPQYAALDN
RADPDFIECKGYVHVGNSRDNLTAENMPWHEDILEFSNALAPLVNRELLDDSPPSRVSLI
GKEIVPIPIPEPTMFFPDDLGIAASVKHLKVV
>A0A7S3ZYB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pelagomonas calceolata|TrEMBL
MHAAEAANYALIATIVLLAAHVVQLLIQKRRKRAPKVAKPTSQFLQDAAPVLIVFASVTG
TSRKLAGRLREALAKAGRASIVVDAAKPQLDPWDELLNGDSRDCAVLVSTVHGGLAPEPS
RRLLVEELDDIAADHRVGQGALRGRRFAVLGCGSTAYDPARFCTAARVTEKTLRKLGAAR
VASQRLDDTEETEETYALWENRVVAAFSRPQVRGEQKPRKVKLEKTHRVSDSSDEEAPQK
KKSVTDVEDMGAALGEKEEEKKAKGPKDMVTQSQAKALKKEGYKLIGGHSAVKLCRWTKH
QLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVFCWRHHKNPVATEWKWKSDDPAMIV
AEAVRLHVAMINECRGVPGVLEERWREAHTVRHCALSLVGEPIMYPRINELIGELHARKI
SSFLVTNAQFPEAIRTLRPVTQLYVSVDAPNKDDLEEVDRPLFRDAWERLRESLVILREK
KQRTVARLTLVKGHNEGDIAGYAELIALGEPTLVEVKGVTFCGKSDASDLTMANCPWHHE
VEAFCKELAARIAKDHPSCPTYEVACAHKHSVSVLLARCDQLKAPDGTWDTWIDYDRFHA
LAASGEPFTVEDYKAPCPPWALLGAAEDGFDPSDTRMYKKKANGKSR
>A0A161X212|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum incanum|TrEMBL
MASSLESAGFKSILNNAHDAWQQVRIPVILFAAFGLLVLRFYLHSTEEKGELKAIPKVYN
REKPETKPVDEKKDVKKDIKPSPPSPTTESKAPKSNGPKRIKGGLVKRTSSDSSNGEALA
RKIRPLIFFSSITANTPKIAKEYAERLEKDLQKAATDTSCSFVTPEVLDLAEVDFDDYFI
TPPKSEEDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFG
DREGWPTEDDGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYSERLSEWSEGVVDVLG
MLAKTGSLGEGLPGSGAPEESDDESAEEDDDEVLIEDSEAKPEKLKNRKNIDDVEDLGRI
MKSSNPEADKNSRTAAAPIAVDFTTYGKTAQKKTPTPAAKEMVPKNSPTYASLTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYC
GTSTASNAGLSMSNVPFYWEVAEFVKALEKRLNEKGLKYGIAAEHAHSCCVLLASERFYV
DGKWHPRIDYQRFFELLEERGPDGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRK
IER
>A0A814SGY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTIDLYIFAASSALTGLVFYYLAGAEWSLWHLFAIPLYTFVFVVFLSLSIIKRFKSLSKP
LQSLTKIIRQEKNGITIVFGSVTGNCRTFAQLTYDKLSKELNYQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDDTPPPSAKWFVNHLQDAATDFRVSKNELEKLTYAIFRCGNS
FYNDNFNTVAKELDRCLSELGAKKLIPTELADENSGKSIYGGREGHYSKWSSQLKSAFQS
PKTDKCDCSNENSIKCCQSLTNNDHPIEKKENDEQLRIESDDDDEDEGCKNGNDDIMDLE
DMGDYMATHSPTKTTKGPPKEMITPVIRKSLEKQCYKLIGTHSGVELCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAMENH
YKIINTFKGVPGVLPNRLAEAMKIRHCALSLVGEPIMYPHINELIDLLHSKQISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKRIDRPLFRDFWERFLDSLRALKDKGQRTVYR
LTLVKDYNTEEIEQYAKLVELGHPDFIEVKGVTYCGDSNASHLTMANVPWHEEVVTFVQF
LCDRLPQYDIACEHEHLNCLLLAHNKTREIVSFVREANDTLVINLIKSGIKTQSVHRMEN
GQYQVDFSVNGSPFCFSVAIDDHIDKNRQLVNDKIPDFIRELEQTLGQVSRKIYNLNRER
GKQQSNTQQEQHHGPTHKKRTSFRGEPAQNFIDREDYLQGAQAAIGWRHPAPARQRQHVA
PDRGPRDVPNPQPSVAPSQSQNYDYIYAPYYTSGPRLAE
>Q9HNF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)|TrEMBL
MSESDGPKQVDDPDYHHENHTAAQTCGWTANAMRGEGTCYKHAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHSGHTYELDGVAWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEAM
EPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPAVLRECDPTQLYVSVDAP
ERATFDDVVGATEDDAWERLVDTMDVLHAKDDTRTVLRTTLVGGQNMANPDWYAGFFERA
APDFVELKAYMHVGDSRDRLGRAAMPDHEDVLAFARAVKTHLPHSVLREQPASRVALLAR
DEDTWVEDLQPESAFWTEGARPTAD
>A0A818HDE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTVDLYILAAGSAFTGLVFYFFAGAEWSLWHLFTIPLYTFVFIVFLSLSIIKRFKSSSKP
SESLTKIIPQEKNGITIVFGSVKGNCRTFAQSTYDKLSNELNCQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDGTPPPSAKWFVRHLQEAATDFRVSKNELEKLTYAIFGCGNS
FYDDNFNKVATELDRCLSELGAKQFIPTELADENSGKSIYGGLEGHYSKWSSQLKSAFQS
PKTEKCDCSNENSVNCCQSSTNNDHSIEKKQNGEQSRIESDDDDEGGGCKDGDDDIMDLE
DMGDYMETHSPNKTAKGPPKEMITPIIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVDGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A485LLS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces stellatus|TrEMBL
MLVIKPSAATAALAVGLAIVTASIAYVVWKSKQEGASDSATKSTKKADGCCGGSSNGAAK
TGCCQTEQAGDEEEEEAKPVSVRILYGTHTGTAKGFASTLEKKLFALNISGYAFEPSVVD
MKDYDQDNLEHEQVVISILSTWTGGVPPESALVFYNWLQDMAQDFRVSRTWLQHVSVAVY
GLGNSEYDEHYAKASKSVSQFFKSLGASRLCPRGVGDDNQDQTAQFDTWSDHVIASLVEQ
YGALQRGRRAQPVAEPGTDKPKEWKSQKEFRRQKRKEKAEADGETDDVMWTEEDQMNEIV
LEDDDDDKPKPKGDGVVDVEDLGVVMKESEAAALAREMITPLQRKALTKEGYKIIGTHSA
VKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGREWRW
KTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMYPHINEF
CRELHARQISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKDFWERFL
SCLQQLKQKGQRTVYRMTLVKEHNMKEIDNYVELIQIGMPDLIEIKAVTYCGKSDASDLT
MKNVPYHQEVRDFCELLCSKLGGHYGLATEHAHSNCVLLAKTTFKIDGHWHTWIDYDKFH
ELIQRYYADGTPFTTMDYIAPTPAWAVYNAPEAGFDPIETRFRRTKEGKVVEIEYTATDS
GCG
>A0A3M9ZW68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp. D6|TrEMBL
MSCSGETVEADDDLIQIRPSTSAQLKKAKYGVSGHSTVELCHWTKKSFKHEGDCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYESMKMDPGQVAEPEVILTELMAERKRLIN
GHYGNPKSDKQRLDESLLPSHYAISLSGEPTMYPKLPEMIKYLNSLDTTKSVFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSYVRINRPRYDDSWERWNRTLGMLRHLDTRTVL
RITLIRGYNDSKDTIPEFADMFSRSSPHFVEIKSYMHVGRSTNRLEHSDMLEMDEIRKFS
GEVVRQSGMFSVMDESQVSRISVLQNNERPINRWISTYAETS
>M1Q3B4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei Tuc01|TrEMBL
MPLEEKKEEQENFGENLPEVQEENTGEEPTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQSKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYIRVCQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEITDESEISRVVLLSKDGRKSPVKKG
>A0A0F8CCY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 2.H.A.1B.4|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFDIPDFTTLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYDK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDIMK
EKRSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISCLD
>J3K376|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides immitis (strain RS)|TrEMBL
MPDETFASGAQRALSLWHSYRGYALVLLPAVFILSHLIAARGKTAEASPPSIPSPPRSSK
AKQSRPTSGTEPPTSTTTPEEGTPSPNGAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDA
TKEISIQPIIFFSSLTGSTERSAKRVLERLNTEPLKDSKRSSRLLAPQLYDLSYVDFDDY
FVSPPKAPESNPNVLYFYCIIIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAV
FGFGDKEGWPTEEEGFCSQAKEVDKWMAKLTGRKRAYPLGLGDVKTDGDKALDEWCSGMQ
EVLCDMVTNNGALGEGVPGSGDPLESDEEDVEEDDEGVPNPGSRPRKARRAEITDLEDIK
FGGDASGKQGSDIPIDFTTYSKTSTSVATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWK
VDPPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFV
SMLHSEHISSFLVCNAQHPDQLAALDRITQLYVSIDASNRDSLRKIDRPLHRDFWERFQR
CLDIIREKTHVQRTVYRLTLVKGFNIDDEVVGYADLVERGLPCFVEIKGVTYCGTSTSAG
AGLTMQNVPFYEEVAAFAVALNDELNRRGLGYGIGAEHSHSCCILLASRRFHVDGKWHTK
INYERFFELLEREKAEGVSFTPEDYMSETDEWALWGNGGFDPNDQRVYRKGKNKANMSDA
GSVPKGGVVEI
>A0A8B9K0C2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
YIIYFGWLWMVWQSRLYVYTAAAVLLGLWLTVNMTLKKKKTVLTSSPPLSKSEKKKEKLP
EKEKVIHVEGVRIFYGSQTGTAKGFARELADDARATGFHSEVFDMKDYDPDDRLSDECTS
KMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSEYVGHY
NTVGKNVDKWLWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRLQALARGEK
KACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESAGEEEKAHGSVIDMED
LGNVMNHMKKAKKQSEEESQRGKLSKLNGVMKTEGEEEAREMITPALREALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPE
INAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFW
QRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGVTYCGESSA
SSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGEWWTWIDYE
RFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNKTKDISGC
>A0A816L6Q3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria magnacalcarata|TrEMBL
MAVDIDILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSSKS
QPSTKNNSDEKNGITIVFGSLKGNSRTFAKLTSEKLSNELNRHVILQDLKDITDPEEFLQ
IQAKEQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAIFGCGNSL
YTENFNKVATEIDRCLSELGATTLLATELADENTGKSIYGGLEGHYSKWSSKLVSALESK
ATGKCGCRANEDSVTCCKSPSTNSHSKETNGTNEVLIESDDDDEGGNKDGEEDVMDLEDM
GDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIDNHYKM
INTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQF
PDEIRVLQPVTQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKTKGQRTVYRLTL
VKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVVTFVRLLCE
RLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGAETFTSLDY
MAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>A0A2E2J4A7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGEFVEKEPELIQIKPNIVQQLKKAKYGVADHSTVELCHWTKKSFKNEGTCYKHKFY
GISTHKCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDEXKVAEPKDIMSKLMEERRKLIV
GHFGDPRQDKQKIEESLIPSHYAISLSGEPTMYPKLPXLIKYLKSLEATKSIFLVTNGQE
PEMIQRLADEDALPTQLYLSTNASDYDSFLKINRPXYXDSWERWNKTLEMLADLDTRTVL
RVTXIXDWNNSEKMISXXXSIFEKSNVXFIEIKSYMHIGRSTNRLEYENMVEMDDVRKFS
EQIXKXSDRFEVMDESEISRIVVLQNRKRFTERXISAYA
>A0A8H4Q000|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps sinensis|TrEMBL
METPNWLSGLRSDTAIDDVVEFWHAHRTSLILCTFFVLVSIRILLYRYEEKVELITLKQI
YQKTESHTVTAQSVSSLLEKTTVTKSNGPRRIKGGLAKKTAQSEREDVDLTRPIKLVVFF
SSVTTKTEKIARGYLASLDKAAEELSQETKRQFQKPELHDLSDIDFEDFFVSPPKSPDDA
RLFYLFLVPSYNIDTINDTLLQHMEETHHDFRIDTAPLASLLGYSVFGFGDREGWPNEAE
GFCFQAKELDKWMSKLTGRKRAYPVGMGDMKNGHAQRFAEWAAGIREVVGNVARNATLGE
GVRGSGDAVESDEEDAADENDQEELEDDPDIEKTTSRALDDVEDLGKMLRTSKDDGNAQN
PRAPLAVDFTTYGSSTKTSQAPAVKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKS
ALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIF
EGVRENHYKKIKMMRGVPGVRADRYAEALKIRHCALSLVGEPIFYPHINEFLALLHAERI
SSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREK
RFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTSTSSNAGLSMSNV
PFYWEVCEFVKALEKRLRAMGLAYGIAAEHAHSCCILLASERFKVDGRWRTHIDYKRFFE
LLEERGPDGEWTPEDYMGAPTPEWALWGNGGFDPRDQRVDRKGRAIENTVIREQPPAEVW
>A0A3N5C384|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter gottschalkii DSM 11977|TrEMBL
MSFNENQIQKLEKSGYRFVGKHRHAAVKTCHWTRQSIVEKGVCYKEKFYGIQSHRCLQMS
PAVPNCQQECEFCWRDLTHTQTEWEDNEYDDPKTIVDEAIEAQNNLLCGYYGNDKANKKK
LEELKKPTNAAISLAGEPTLYPKIDELIGEFNHRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPNEKIFNEICRPRINDAWNNLNESLETLSSFNSRTCIRNTCVKGRNMEQPEKYA
ELIKKADPDYVEVKAYMCVGSSRDRLTLDNMPTFDEVKSFAKRIGDECGKELVNESEISR
VVLLE
>A0A284VSC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedens nitroreducens|TrEMBL
MSNSEPMKPITESTKDLLKKHGYHLAGTHGAVKTCLWLNKSLRNDGDCYKSKFYGITSHR
CIQMTPTLVCNHRCLHCWRAVEAPVEVPEKWDSPQDIVESCLAGQHRLVSGYGGSEIMDK
TKWKEAFTPKHVAISLSGEPTIYPYLPELIEEFHKKDLTTFVVTNGTNPGMVGDIKPTQL
YISLNAPDKEAYGKVCRPLGDTWENIKHSLEVMKDFKARTAVRITLTKGVNVSAPEGYAR
LIEAAEPDYVELKAYMHLGFSRMRLSRDNMPSHREVLEFSKEVALALGYLIADESEASRV
VLLSKDGEKRDIV
>A0A179FCP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pochonia chlamydosporia 170|TrEMBL
MSAVCEKTDPLQGVFGVHHGTKFDDIVELWHGHRTPIIFCALIVLVAIRFYIHNVEDAEP
LKSIPKQFETKVIPDGTSKQSDIDVSEKTTAKSNGPRRIKGGVTKKPATEEKDQYDKSRP
IKIMVFFSSVTTKTEKIAQQYLSSLERSVDQLSRETERQFLKPELHDLADIDFEDFFVSP
AKTADNAYLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLAPLLGYSVFGFGDRE
GWPDEAEGYCFQAKEVDKWMSKLTGRKRAYPVGMGDMKSDHADRFQEWTLGVQEVIGHVA
RTGTLGEGVTGSGDAMESDAEDVAEEDDGEVLFEDDASSDDKESSRPLDDVEDLGRMIRP
SNGGRTANAANGKKAPLAVDFTSYGSSTKKRTPVAPVIKEMVAKNSPTYAALTKQGYTIV
GSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVG
TTWRWVVDPPDMIFAGVKEGHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYP
HINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDF
WERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCG
TSTSSNAGLSMSNVPFYWEVCEFVRALERKLKDKGLPYGIAAEHAHSCCILLASERFLVD
GKWHTHIDYKRFFELLEERGPDGEWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKI
ENVVVREAPPPESW
>A0A151HPL6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii TgCatPRC2|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHYSGSTGDALSPPEQQDARRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLRLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQRNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ARGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
NQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
TFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQIRLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDERH
RMHAIGDERATGEGSDIDTKGGDRELQSTVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGREARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLFCLDLLKEKRQRTVYRLTLVGGYNMDD
PSANVSKECHTGAKPQGSSAAASAVGENSINEVERMCCRPATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREETTGEKADKERGKTKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>E3S8Q0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora teres f. teres (strain 0-1)|TrEMBL
MVFLQYAEQLPTELLLIWREHRLEILLSALVVATIARLVIYSRDRKREKVSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLLNVDNHAEDDAAAVRIVSKAKKGPKTVKGRKIQKKNI
VPVSTFDHKADKIQLLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQTLDISY
IEHDDYFISPPKADANVKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GIQEALIEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSMVNSSS
APIPVDFTTYKKAAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIQHCALSLVGEPIFYPHINDLLSIMHNHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNTRGLQYGIGAEHAHSCCVLLADKTRFQKNGRWATRIDFERFFD
LWEGKVKGTRVEGGEVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKTEEKI
EGEGEGESKVERAKALEF
>A0A672UST3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigops habroptila|TrEMBL
MDTWSFFSTCLVSLWLHRLYVYSAVAFGISIWIIIQFSTSKHQKKNSAEHFPFVTEGVFN
GCATLQAKEVYVAGVKIFYGSQTGTAKRFARALAEAVISLNVPVEVISIGDYDPDDCLLE
EVGTNICVFLVATYTDGQPTESAAWFCRWLEEAANDFRFEKTYLKGLRYAVFGLGNSVYV
DHYNTVGRNIDRWLWMLSASRIMTCAEGDCNVAQSKHGTIEADFEAWKAKFLSRLQALCR
GEKKPCSGKCKKGRCKSPGKQSKESSDHEHGASEYENTEAEALFDTSSEAEADAEEAGGT
NSVVDVEDLGNIMRHMKQAKRERELEEGDVGMSLTRENAGRKEEGGKREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEMILQQAIENHQNMIKQFKGVAGVQAARFEEAMTAKHCALSLV
GEPIMYPEINRFVRLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRID
RPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGV
TYCGKSSASNLTMANVPWHEEVVHFVQELANLIPHYEIACEHEHSNCLLIAHKKFKINGE
WCTWINYDRFQELVRAQEQSGGSQTFTGADYAARTPHWALFGSRERGFDPLDVKYQRKNK
ARDISGC
>D7DQL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus voltae (strain ATCC BAA-1334 / A3)|TrEMBL
MITNSNTIKQDKPKKSQKTQNLEKRIPQIPEQLYNILRKQHYQIEDHSAVKLCGWVRKSF
LENKDCYKSKFYGINTHRCVQSTPSVIWCQQQCEFCWRVLPSDLGIDEPNFKEPKWKEPE
EVAEDILKMHKTIITGYKGIIDRIGAEKYAEATEPKHVALSLAGEPTMYPYLDELIEIFH
KKKMSTFVVSNGVLTDVIEKINPTQLYVSLDATDLESYKKICRGTEQNWNSILDTLDLLH
EKKRTCLRTTVIKNINDDLSKFAELYDRANVNFIEVKSYMNVGYSRKRLNLDDMIKHDEL
IKISKEIEDKSAFEVIDDSQDSRVVLLSNTLENRCINPKIDFENL
>A0A0B7JHI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bionectria ochroleuca|TrEMBL
MDHANSVLSLGLPDSTDGWIDIWHNHRGPIILATTTVLLAFRYYVHRNEEREGLLVLDKK
FDEKEKPVIGDDTPKTIVDEKQNLKTAAGPRRIKGGLAKSPPSQNQEKRRGNGPVKIYVF
FSSITTKTQKVAEGYVEKLAARIDQFSEESGRQFLRPELKDLTEIDFEDYFVTAPKVDED
ADVFYLFLIPSYNIDTINDTFLQHLEETHHDFRIDTASLSSLMGYSVFGFGDTEGWPNEA
EGFCFQAKEIDKWMAKLTARKRAYPVGMGDLKGDHAARFAEWATGVQDVITSAARTGSLG
EGVPGSGEPVESDPEDVEDEEYDDGEVILGDETSNTKSNGSRDLDDMEDLGKMIQPSDSA
KATKKTKAPLAVDFTTYSGSSKKKGPTAAPKEMVAKNSPTYAALTKQGYAIVGSHSGVKI
CRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVD
PPDLIFEGVKKNHYHKIKMMRGMPGVRAERYSEALRIRHCALSLVGEPIFYPYINEFLAL
LHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDYWERFQRCL
DILREKRFRHRTVYRLTLVKGFNVEDEAEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAG
LTMSNVPYYWEVCDFVRALEKKLKEKGLNYGIAAEHAHSCCILLASDRFYVDGKWHTHID
YDKFFELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDDRVDRKGRKIEPVVVRDR
PADAESW
>A0A0A7GC68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geoglobus acetivorans|TrEMBL
MVKSLEELKGYQIVGKHSAVKTCLWLKKSLKDQGYCYKQKFYGIASHRCLQMSPALICNF
SCIHCWRPLNLMPPFENWDEPEYIFEESIKAQQRLLSGFHGTEGVNKKKLREAYEPNQVA
ISLIGEPTIYPKIAELVDIYNKNGFTTFLVTNGTNPDAVEEVEPYQLYLSITAWNEESHR
RLQNAGLWDRIERTMKIMSEKDAKTVIRLTLIRGINMNPERFLDVINAAQPEYIEAKAYM
HLGHSRLRLSRDAMPEHDEVKAFAERLAKLSGYEIKDESEISRVVLLER
>A0A1Q7XBH8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_20CM_2_39_20|TrEMBL
MSCSGETVEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFKNGGDCYKHKFY
GISTHKCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVGNLMEERRRLIM
GHYGDERNDKSKLDESLLPSHYAISLSGEPTMYPQLPELIKYLKKLITTKSVFLVTNGQE
PDMLQRLQDEDALPTQLYLSTNAPNEEIFHSVNRPKYKDAWERWNTSLEILSKLDTRTVL
RITLIRNYNCDDELIAEYVKMIKRSNVHFIETKSYMHIGRSTNRLERSDMLEMPEVRHFS
SELAKQTQIFSVMDESEISRIVVLQNRRRIIDRWIASYANTN
>B1YDT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)|TrEMBL
MSCEAEALGRYHLLEGPRIKIRASAARALIERHYGVAGHATVELCKWTKEALETGRSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDAFQLEEAFYMEPEEIVRGVLE
ERRRLLSGYWGHPQGRRRVREALEPTHWAISLSGEPTMYPKLPQLIKLVKSLPSTKSVFL
VTNGQHPEMLRRLVEEDALPTQLYLSTNAPNRELYYLINVPVYRREDAWERWLESLDILA
KVPTRTVLRITLIRSLNYDGRYIPEFAQIVKRGNPHFVEVKSYMHLGHSTQRLRREDMLS
HQEVREWAFKLLAELEKIGARFRYMDEDEASRIVVIQNMDRYVDRWIVPPR
>G0EDU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrolobus fumarii (strain DSM 11204 / 1A)|TrEMBL
MQKTSVKRWRLKLEEIPEPYRTVYRTLQKQGYIFVGRHTAVKKCHWVHAALTQGRFCYKC
KFYGIASHRCIQMSPTALWCWNACLHCWRLRPQDVGAQWDEVNMPFVDDPEMIAEGIIEA
HRMSLAGYRAHPKVDPKMLEEAMNPKHVAISLTGEPALYPRLGELIREIHKRGMTTFLVT
RGVRPDVLANLEEEPTQLYVSIEAWDKKSYQEFNRPLVPRTWELVLKTLELLPSFSSPTT
IRITLVKGFNMHDEALRGFAKLIELAQPTYVEVKAYMWLGASRYRLPKDAMPKHVEVRVF
AEKLAKLTGYKVLSQQVESRVVLLSRLDKPIRVGEGCPDGWKQRTELDDQIEYELAKLQE
QGKI
>A0A7S4KKN9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Guillardia theta|TrEMBL
AAAAAAAAAAAHAGNKGGGKGGGSSRMAGKFGEFLPANQYRRLKRSMAKKQAGVGMYVGG
QASFSSSSSSSSSSAPFPLGFQFAVCGLGSSSYKSSYQKAAHTLCELLERCGGKRVGPVG
EEDEMFSGQGFELWCKQTLPLLNEEPERRRPEAREESRTLRILWQGDIHEQAARVAGEIA
EKARDGGAGAGGELAVIAEPLDRFDADSLSTEEALVLVLHRPMSEEEEDGNATMSSEAWL
LEHMKDCYEDERVDKTLLRDLKFGVVYIENNNRTMKDAKLLDFYMFSLSGRRILPVTRVQ
RTGKLSDQVQAIAQQLRRNLFPILPSLHDSSHAASDGSRSARDAAVRTSPPTPPPPASAS
LTDIEDVGGVEGSSKEMLSPSMRSSLEKQGYKVVGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTSWMWDMNEPEDILEGCFKGHYDSIR
SVSRVPGVLAPRLAEAFAVRHCALSLVGEPIMYPKINRFVSLLHHNGISTYLVTNAQFPD
AIRDLEPVTQLYVSIDAANPETLTKIDRPLFEDSWSRLAQSLRALKDKDCRTVYRLTLVK
DKNVDDVANYAKLVALGRPHFIEIKGVTYCGTSKASEITMESVPLHSEVVQFARELVEAI
RAEPSVEDEYDIASEHEHSCCILIASRRYLIGQQWHTHIDYDKFITAWRRWLETKELDVM
SYIAPTPPWAVFGAEEQGFDPKEKRMSSKRSREESARLRMEAKNAKGSDLPRVDSNDMSH
PQG
>A0A7J3E3S5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLKIPERLEKLYRRQGYRIVGKQKHSAVKICQWTKSTLRGGEPCFKQKWYGIQSHRCLQC
TSWLSCLNDCLYCWRSFKIPLSLKKVDEPSELIDEMIKEQRALLSGFKGNKKTERKKWEE
AQNPNNAALSLIGESLLYPRISELLREFHERGFTSFLVTKGTLPERLARLEEEPTNLYIS
LSSPDEKTQKFLERPLIKNAWKKQLESLKLMNSFSCRKVIRLTLVKGFNMEKQENYARLI
LMAEPDFVEVKAYMWVGESRNRLPGSAMPSMDDVRSFAEGLSKLIGYKVKDDNILSRVVL
LSKK
>A0A1I8GJC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
QSASKMSHWDLTVHISRALQNSSALSYSLLLAASVVGAWILFQRRGRQGHVISASSVKKA
VLSSSSQMSLRSPTTRKAMLPTTSCTSTANGSVDETFNKVRVFYASQLGRAKHFATLLRD
ELAGVLKQQKQQQQQSQCCNGGDGEACKSTTVSSSDSAGIELIDLANYDPEESLHKEIAK
RVDEQLTQLSGTRLRPPVLLDENVASATGHGGQEADFQAALQSQLLDPLVSKKKKSACCS
EATGNSACCQGAEAASDVAEDHSDVDSDHLDEEDQDGLVDVEDIGGVLSSATRSNQKQKL
RQEATTRRAMVTPLVRKSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIASH
RCMEATPSLACANKCVFCWRHHTNPSPDTLCYFLLPTYEGGSSPNTGAWFCKWLAEAAED
WRVERGHLSGLRFIVIGLGNSLYAENYNLIAKRVDEQLTQLSGTRLRPPVLLDENVASAT
GHGGQEADFQAALQSQLLDPLVSKKKKSACCSEATGNSACCQGAEAASDVAEDHSDVDSD
HLDEEDQDGLVDVEDIGGVLSSATRSNQKQKLRQEATTRRAMVTPLVRKSLEKQGYRLIG
SHSGVKLCRWTKSMLRGRGGCYKHAFYGIASHRCMEATPSLACANKCVFCWRHHTNPVGT
EWRWLEDPPDEILSGALDAHRRMIREFRGVPGVMPERISEGMQPRHCALSLVGEPIMYPR
INQLLHLLHTSGISSFLVTNAQFPEAMRQLPPVTQLYVSVDAATPDSLKRIDRPLFKDFW
QRFIDCLRAMRDCGQRTVYRLTLVKAWNTEKVQQYAKLVDLGCPDFIEVKGVTFCGDSKA
SQLTMGNVPWHKEVVQFSQALADSLANQYDIACEHEHSNCVLLANKRKFLVNNRWHTWID
YDRFEQLYGRFVETGQRFNAADYMAETPEWAVYGSAEQGFDPNETRFHRQRQSATGMSGA
LLGGSVDVDVLLPSGFLLVLTCSADVPLCDLKKLVWSEAHKAGYYSESLDQDSYVFSGVI
LEGSTEDFLEETQRLSQLRLFIPMLSLRQSHDMKSDKTREALVFHSIGVSAKDLGRVMDA
EATSFRGAAFATVKDACQQTRNGGADQVFHFRTGATCEDTSPIIRHKSSTSSASASNNSS
DRLSFTGPAISPSSIHKVQVFHRSGNQTMRFTIQLDLDHSYPSTVVEEVARKPQSRQQIN
PNRYLVKVCCCNQYLTSRSPLSSYDYFRHCLDSNVTPCLMLVEKDASFDSVSEPGCCNFY
SMPEYLSNLAASDRTSTSSSYAMVREDSLSQPALARPMDLWNCVNEYFTVHVTSVQVSDP
PNGQLYLRAGIYCGSAPLCGNLTTRAMRSCNAESISEPLMFDVLVSNLPIYARLCLALCY
VVRRHTTDEHNCLGWSNVNIFAYDGKLRSGPIQMRFWTEEFLGGVGQQSSAGAVDFLKPL
GTTFGSNQSDAPVAEVMFPESRLCFPDKDSLNSMLQQSPLTPSSNRPGWDVIPPNKEEQL
QDQLKSILNRDCLSELTDSERDLVWYYRQDCCARHPASLPVLASAVNWANRHDVLKFYYL
LEQWKRPLPLHTSLQLLGPKFMDPRLRSLAVESLDQSLTDKLFRRLLLQLVQCLKFEPFL
SNRLTHFLLRWSLRSVRSGVRFFWYLWSEIHQQQLRLRFTLILEAFCRGFGPGLNLLSRQ
RDAIDKLVTMANTLRSERDDQQQKVFQAMLQTQELVNDISMFTSPLEPSEELGMLKPERC
KIKKSKKRPLWLEWVNPDPMASQHLTDYKLIFKYGDDLRQDMLTLQLIALMEDVWRQELG
FSLRMSPYNCLATGRHMGLIEVVRDAYTVMGIQKERTRVAAMQMDSSQLYKWLLEQNADS
STHETVVDTFTKSCAGYCVATFVLGIRDRHPDNIMLCRTGQLLHIDFGHFLNNKKKKFGI
ARERVPFVLPQDFVRIICRDKDGSMTWRELTSRREFTQFATLCSRAYQALRQNAALFLTL
FTLMLHSGIPELQSPQDLEYLRSTLALDRRESDALIYFNKQLTEALQNAWTTKIDWVGHW
VVNTE
>A0A1I8GKG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
SPDTLCYFLLPTYEGGSSPNTGAWFCKWLAEAAEDWRVERGHLSGLRFIVIGLGNSLYAE
NYNLIAKRVDEQLTQLSGTRLRPPVLLDENVASATGHGGQEADFQAALQSQLLDPLVSKK
KKSACCSEATGNSACCQGAEAASDVAEDHSDVDSDHLDEEDQDGLVDVEDIGGVLSSATR
SNQKQKLRQEATTRRAMVTPLVRKSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHA
FYGIASHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWLEDPPDEILSGALDAH
>A0A4Q4TMU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. GIB2|TrEMBL
MSATFWESAADDNRGLTAVLFAVWLYLQLSQRQGKSAGSPKLEPGKSLPAELVAEEKVSL
PTAKESSSGPRRIKGELRKVNGPKSAVQLDRQRRVQILVFFSSLTGSTERTAKQLIATLE
ASLLDHTSGSDQAFLKPQLLDLTQIDYDEFFISPPKSAEASQPVDYFYLILLPSYNIDTI
NDNLLEHLKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQAKEVDKWMAKL
TGRKRAYPLGMGDPKRDLKERLAEWTGGVTEVVRQIAKTGCLGDGVPGSGDAVESDDEYV
SGEDDEGDVVDDELVQPKKSKKSTRDIDDVEDLGRTMKASRADANDAIGRAPIAVDFTTY
SKTPKKPPQAVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKM
MRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHGERISSFLVCNAQHPEQ
LAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDILRERRFRQRTVFRLTLV
KGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSGGKDGGLSMANVPFYAEVTAFVE
ALDRRLRERGLGYGIAAEHAHSCCVLLASERFRVEGRWHTRIDYDRFFELLEERGPDGEW
TPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIET
>A0A8C8XVM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panthera leo|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDQQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVTLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTREKPQAERIQAELEFNPRCF
KIQSLL
>A0A8J8DZ60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. GR6|TrEMBL
MAITFKSNPNMPGEIARLFKKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCSHNCIFCWRPMEGFLGTELPGPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTAPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKITRTLELMNGLPTRTVIRLTLVKDE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A8C5DVA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
MFSVLVLVLSVLCPVLSSGIKGSKDVYSGSEKYLLWVWHNRLYLYTAAALCFGLWFSLKM
VLKKKSVPSDLVLWVQKSAEKNDRAEVHVSGVKIFYGSQTGTAKGFAAELSEEVKTLGIP
SEVIDMKDYDPDDQLADECTSRTVCVFIVATYTDGRPTENAQWFCKWLEEASTDFRYGKT
YLKGLRYAVLGLGNSAYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQD
DFLAWKAHFLRRLQALARGDSGSRSSKSSCMKTDGADHEGEEPTLTNHSSEEELMETSSD
EEQSDERTSGSVVDVEDLGNLMDSVKKSKNEADGQMVKLAKVKKIKDKEGASREMITPTL
RNALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWLWKMDPAEKILEEAMEKHQNMIRQFKGVPGVLPERYQEGLAIKHC
ALSLVGEPIMYPEINTFLRLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDS
LKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFI
EVKGVTYCGESSASTLTMANVPWHQEVVAFVRQLADMLPQYEIACEHEHSNCLLIAHTKF
KVDGEWRTWIDYERFQELVEAHEASGGTRSFSALDYMSQTPHWALFGAQEQGFDPADTRF
QRRNKTKDVSGC
>A0A075WNV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus fulgidus DSM 8774|TrEMBL
MMNEKLLSELKGYQIVGKHSAVKTCLWLKKSLKDEGVCYKQKFYGISCHRCLQMTPALMC
NQNCLYCWRPLELLKGFRGWDEPEFIVEESIRAQHRLLSGFHGTEGVNRKKLEEAYEPNQ
VAISLIGEPTLYPMLPELIEEYKKRGFTTFLVTNGTNPDMLEKVKPTQLYLSLTAFDEDS
HLVLNRPGKSNWERVLRSLEVMRDSGSRTVIRLTLIRGYNMDEEAIRKYSELIEMAEPDF
IEAKAYMYLGYSRLRLRWGNMPEHADIVEFSRKLADSTGYEVKRESEPSRVVLLERVK
>A0A8H5W6K0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sp. NRRL 52700|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLALCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIDDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYRGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVIFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSKKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>T0LYA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon Gpl|TrEMBL
MENKYAQVYKKQHYGLVGKHSAVKVCHWTKSEMTGGASCYKGTFYGINSHQCIQMTPALN
SCTENCSFCWRFNGFDSMHIGDEDDPEFILNESIKAHLKLISGFKGNPRVTEEKWKEASN
PKHIAISLTGEPTLYTRLGEFIKLAHKRGMSTFLVTNGTLPMVLEKLNPLPTQLYVTTAG
PDKKTFNELLNPAMGNAWENFQKTLELMPSLDTRKVIRHTLVKDFNMPFIDEYAKMDSIA
QPDFIESKGYVHVGQSIARLSIDNMPSHNDIMDFTVKLGEKVGYEVTAERKESRVSLLAK
DPSKSKINFESI
>A0A068UIR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coffea canephora|TrEMBL
MSPSLSPTRLTLLTLLSATTLYLFYKSHRRLLHRLKTFKTLNPDPRGKIFFISQTSTSKG
LAQRLHNLLTLNNLPFDLIDPKDYEPEDLCKETLVLVIASTWENGEPPQNGAFLVNWVNE
SAEDFRVGAALLVKCKFAVFGVGSRAYGETFNAVGKGLSGNLRKLGAKELLEICEGDVDG
GDLDKVFDGWSQKVVEALTDNLKENGVYFGNLNGVDGEASDEEEYDDEDDEEGENGGESE
LVDLEDIAGKGPSRRKEMVEAKANGELNGVTGKKAMVTPVIRANLEKQGYKVIGSHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKM
DDPLEIVNTAIELHTKMIRQMKGVPGKY
>A0A5N5MJL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coniochaeta sp. 2T2.1|TrEMBL
MAATSGVGRLPPDLDVLTPIPPVLQKGMAAIAVLACLSFIASGLTVMYLAFKIVRWHVRQ
RREGKISPHSPGVDLSLGLAPRHFGGGDGQQGDNHREAPNQFLILLFNLLIADLHQAGSF
LISGVWLAKDMIDVGSPGCFLQAWLVSTGDVAGGLFLSAIAVHTYSNVVWNRKPSQWAVY
GAVIGIWVFTYFISALGIAITRNGRSDGGFYVRAGAWCWINVRYENLRLLTHYLFIFLSL
AVVSILYTLIFFNLRRRHNQPSLEFAPSQSRPDDQTLPKSSLDLRTKVPQVNPTHPSPKV
RGHHPAFLIYPVIYVVCTAPLALGRIATMAGASVPIGYFCAAGALITSNGWLDVLLWGLT
RRVLLFGSEIDAEDVGLETFTFMRTPPERKFGNMVWVQGASRGTREDDEQDQGRTADDAK
DGFGWWRGAANWRRARSSKRPGSGHRRNGSMSGQLRSHKRLGSRSISQESLRGAGAGEMA
IQMDIVTSVEVEVDVDKLGTRHREYSTDNESLAADVLQLWHSYRIPAIMVTFATLMVLRA
YLHGTAEKPHLRVFPAVLNAPGKKETEEKEARPRIPKNDALFQTLYNAPEQKTKDKKAAS
QSPRNDALFPTLYNAPEKKEAEQTKPSTKAPNDSAPTTQTAAKPKSAPRRIKGDVGGRKS
SPDRNGSGVREIQVYTFFSSLTGNTEKIAREYNTKLESSLKAINPQEGESFSFLAPQVFD
LAEADYDEYFISPPTVQTQNIGRPAEVFYLFLLPSYNIDTINDNLLEHLKETHHDFRIDT
APLSGLLGYSVFGFGSREGWPTEEEGFCCQAAEVDKWMAKLTGRKRAFPLGMGDVKGDGM
QRLEEWSEGVLDVLGMVARTGSLGEGVAGSGAPAESDDEEVEEDDDGEVLFDDEVPTKSG
KSKKGGDLGDVEDLGRIMQDSRPYGVDVKAPIAVDFTTYGKDSKGRAKTTTVTVKEMVPK
DSPTYNSLTKQGYQIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSC
SNKCVFCWRHGTNPVGTSWRWVVDPPDLIFSGVKEGHYKKIKMMRGVPGVRAERFAEAMR
IRHCALSLVGEPIFYPHINEFLGMLHAERISSFLVCNAQHPDQLAALQHVTQLYVSIDAS
NRESLRKIDRPLHRDFWERFQRCLDILRERRFRQRTVFRLTLVKGFNIEDEAEGYADLVE
KGLPCFIEVKGVTYCGTSTSSSAGLTMGNVPFYHEVCDFVKALDEALRRRGLEYGIAAEH
AHSCCILIASERFRVGGKWHTLIDYEKFFELLEAKGADGDFTPEDYMGAATPEWATWGNG
GFDPRDQRVDRKGRAIEI
>A0A8D3EF17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MALKKKSFSEDVGPLVYKAVTNSDRSDRDTVVHVSGVRIFFGSQTGTAKGFANELSEEVK
TLGIPAEVTDMRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKEDLMESSS
DEDESGLQDEKKSGSVVDMEDLGNIINIAKKAKVRPYPLTDRQHFYHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQD
AVENHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSQHISS
FLVTNAQFPQEIRTLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQ
RTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVV
VFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVAGEWWTWIDYERFQELVQAHGDSGGQ
QSFCALDYMAKTPGWALFGACEQGFDPADMRFKRRNKAKDISGC
>A0A7J3QEA1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MQIESMGQKDSISYAFNVLRKQKYHIIGSHSAVKKCYWVHKALTERLFCYKAKFYGIESH
RCIQFSPSILWCWNYCLHCWRYRSEDQDRNVWNRFPENIDDPRTLVEMAINEHRRTISGY
RKYPNVDLAMYKEAMDPRHVAISLTGEPTLYPRLDELIEEFHRRSITTFLVTRGIRPDIL
SNLRIEPTQLYVSIEAFDEDSYKYFNNPISFMLWKRTLETLEILPSFTSPTVVRITLIKS
FNMNLEAIEKWAKILSKAQPTFIEVKAYMHIGVSITRLKRSDMPSHDEVRKYAEILAERI
GYGAVSESRPSRVVLLSRFNKPVIRYGNPPINWYDIEKVDEYQDKYNYLYEVI
>E4ZRA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)|TrEMBL
MSLSNSMAQLPIELLQTWHAHRFSLLFTAVVVAAVLRLCVCTRGRRDKVSVSPTPSSPVE
KKVVELRPEWLPENTTTVNPPELNIDGHAEDSTKTAASLVKPKKGPKTVKGNKVPRKKKT
VPAPSFDHKADKIQPLVFFQSLSGTTERYAAQFANTLTEWTAGCDQSSSFLAPETHDISY
IEHDDYFITPPKADANVKFFYIILVPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLG
YSVFGFGDREGWPTEEEGFCSQAREIDKWMARLTGRKRAYPLGMADAKKEAEDRMQEWRV
GVQEALVELAEGRGLGEGVPGSGDPAESDEEDTDDAEDIAAQSTRVDDVEDLGGMVTTNS
STTAIPIDFTTYKSASKSKSAPTSAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWT
KSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPEM
IFDGITAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLTIMHKH
RISTFLVCNAQHPAQLAALIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILR
NRRFEQRTVFRLTLVKGFNMAEEVKGYADLVQRALPGFVEVKGVTYCGTSAAGSAGLTMQ
NVPFYEEVAAFVTQLEAELRARGLAYGIAAEHAHSCCILLADESRFSRQGRWATRIDFER
FFELCEGVVQGTRREGGQVVGWRPEDYLGEDTPEWALWGNKGFDPRDQRVYRKGKGPRVE
EGGGGGKEEVKSVAKALEF
>A0A1B7NYG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emergomyces africanus|TrEMBL
MARDELAIAAQGLLSLWHRYRVPILFLAPVVFAVVQLFPRNSKPDSLSLAATPPSPNKRQ
NAKAESDTFGVSTSDSLAVAQPKRNYSRSSSADTGNARAKQHANGPKRVHGTKPARNGAK
NQTRGLAQEIAVQPLVFYASLTGSTETHAKLFCDMLQKASNSLVASSKGTLLAPELHDLS
YIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMIDTFLAHLDETHNDFRIDTSALS
GLAGYSVFGFGDREGWPSEEEGFCSQAKEVDRWMAKLTGKKRAYPLGMVDVKGDNIQRGL
SHWCDGVRDVMYDLMASGGLGEGVPGSGDPFESDEEGIDDNEESGEVSQNRQKTSRTEQI
VDLEDIKFGASDKKKTSTDSQLLAIDFTTQIRAQPSKLAPPHLEMVPMSSPTYAALTKQG
YTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWKVDPPDLIFDGVKAGHYKKIRMLRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKIDRPL
HRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEETAGYADLVEKGLPCFVEVKGV
TFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELARRGLEYGIAAEHKHSCCVLLASNR
FHFDGRWHTRIDYDKFFTLLEKEKTDGISFRPEDYMRETEEWALWGNGGFDPKDTRVYTR
GRNKGKLNAALKESQENAGSIDS
>A0A3M9ZMA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon S15|TrEMBL
MSCSGEVAEPEGIVQIEGLKAARLRRAKYGISDHGTVGLCHWTKRSFRGRGTCYKHSFYG
ISTHRCMEFSPAGMHCQNRCVYCWRPVEFYDSMAIEAPRAADPEEMMRGLMAERRRLLMG
HYGDAAADSALIDEAQLPSHYAISLSGEPTMYPHLPELIRHLKSLEATKSVFLVTNGQEP
SMIRRLRDEDALPTQLYLSANAADRESFMRINRPRYADSWERWNETLGLLDGIGTRTVIR
VTLIRGHNADAKGHGAFARMLESSGAHFVEAKSYMHVGRSTERLERESMLEMDEVREFAR
GIEVRGPFEFMDESEVSRIVVMRNSRRPIERMIAAYA
>A0A7K6PWW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ifrita kowaldi|TrEMBL
LDVSMDTWSYFHACLVSIWLHRFYVYSAVAFGISLWIVVQIATTRTKRKKSHGNPASSEG
TADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFARALAEAVTSLNLPVEVINMGDYD
PEDGLSEETHSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCRGEKKPCTGKCKKEKCKSSGKQSKESSDHEYGTSEHENTEAEELFETSSEEEA
GGTDSVVDVEDLGDIMGHMKKAKVLLLEGVWNGQVLVTEQAKLNCLMNFALFSGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALMVKHCALSLVGEPIMYPQI
NRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSAS
SLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKVRLLG
>A0A0V1LIH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella nativa|TrEMBL
MMAYLTTHIRQGVSFFVPSKQSTFRKITINTMKTPCHVELYNTYNMWKAYYNMYERTLHV
FCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREEVKIFFASQSGNAQKL
AYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDGQCPEKCRWFFKWLEE
CVSDFRVEKSILSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLLKANNILPLYLTEDDN
FDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENENSSDAEDAENSANNVG
DIEDIYFTNVTNDSNKIKEMLTPTLRKSLAKQGYHLVGTHSGVKICRWTKSMLRGRGGCY
KHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPAEKILSDSLEGHKK
MVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQ
FPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILREKKQRTVYRLT
LVNRYNMNEVSQYAALINRGQPDFVEVKVGVTYCGDSKDSKITMANVPWHADVVDFVQQL
VFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDY
MAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A090CVK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)|TrEMBL
MLCSPHIVDAVDLWHEHRIPILLSTAFILTFLRFYLRLNDAQSEQQKLVALPRALNKDEK
KTTTTITEKLDKVVVKKVSSSEGSSGDDEKKEGVKKKIAGPRRIKGDASKRVKKEGGEAR
KIQVLVFFSCLTGSTEKIAKQFAGAFKEALTKAKGEQTTFLPPQVLDLSEVDYDEYFISP
PKTEGEEKVDYFYLILLPSFNIDSINDTFLEHLQETHHDFRIDTSPLAPILGYSVFGFGD
REGWPTEEEGYCFQAKEVDKWMAKLSGRKRAYPLGMGDWKRDGKERLAEWKSGLVDVLGQ
IEQNGGLGEGIPGSGDPIESDDEELDDDGEVYDESAEQNGKSKSSGDLGDLEDLGQIMAA
SGNTGKKSSGPIAVDFTTEGKPKRKAAAPAVIKEMVPKGSPTYNSLTKQGYAIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWV
VDPPDLIFNGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFL
GMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKESLRRIDRPLHRDFWERFNR
CLDILRERRFQQRTVFRLTLVKDFNLEDEVEGYADLVQKGLPCFVEIKGVTYCGTSTSSS
AGLTMQNVPFYNEVCDFVVALEKALKKRGLNYGIAAEHAHSCCILLASDRFQKEGKWHTR
IDYERFFELLEERGPDGEFTPEEYMGPETPEWATWGRGGFDPRDQRVDRKGRPVEVS
>T0MX75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon I-plasma|TrEMBL
MDEVKKRALEKQGYKIVGNHSGVKLCHWVRQDLYYNRPCYKNTFYGIESHRCVQMTPSVD
WCSENCTFCWRSQGWEGAKIPQEDDAADILEGSIQAQRLLLTGFKGDSRTNLKKWLDAQN
PKHMAISLTGEPTLYGKLDDLLREAKERHISTFVVTNGTQPDALEKLKVLPTQLYVTVAA
PNEKLFNEMLNPIYKDSWERLNRTLELLPSLKTRTVIRHTLVKDFNLGYVEEYYRLDRKA
DPDFVENKGYVHVGGSRNRLTINNMPSHEEIRDFSSRLNGYLNYEFGGEREDSRIVLLSK
DRKKNKIDFSAI
>N0BD55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus sulfaticallidus PM70-1|TrEMBL
MVKTLSELKGYNIVGKHSAVKTCLWLKKSLKDEGVCYKEKFYGIKSHRCLQISPALRCNL
SCIHCWRPLSLMPEIDGWDDPQFIVEESIKAQQRLLSGFWGTKGVNTKKLEEAYKPNQVA
ISLIGEPTLYPFIAELVDEFNSREMTTFVVTNGTNPNAVDRLEPYQLYISLTAYSESSHK
TLNKPHGNLWDKINRSLEIMSEKDCRTVLRLTLIKGINMNVERFAGLINKANPDFIEAKA
YMHLGHSRYRLERSAMPEHDEIRDFAEKLEKLADYRIVDESEISRVVLLERK
>A0A3M2TEC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus sp. HF37|TrEMBL
MSEGLLAFWHAYRLPLLIALTTAVVVLQAYRSSQFKTKTAASSSVPPSPRSHSPEKNEKT
SVADGHSPTEKIDKSASPSTQTKTASGPKRVVGKKPLKNGRQARPRDGQPLSFIQPIVFF
ASLTGSTERYANILLENLRAAAQNRADPNNRERGLLPPQIHDLSYIDFDDFFTSTPKPPS
TSPSTRYVYCMLIPTYNIDTVLNTFLGHLDETHHDFRVDTGSLSNLAGYSVFGFGDKEGW
PTEEEGFCSQAKELDRWMAKLTGKKRAFPLGFGDVKSDAEHALKEWAQGLQDIFFDILEH
GSLGEGVSGSGDPLESDEEDLEEDEQGDTKAKKRNKPQQVTDLEDIKMNSGNNTASGSPL
PVDFTTGGKAAAPSENNAKEMVPQTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPDVIFNGVKEG
HYKKIKMLRGIPGVRAERFSEAMRIRHCALSLVGEPIFYPHINEFVGMLHREHISSFLVC
NAQHPDQLDAMDRVTQLYVSIDASNRESLRKIDRPLHRDFWERFLRCLDILREKRHFQRT
VFRHTLVKGFNVEDEVMGYANLVEKALPCFVEIKGVTYCGTSSSAGAGLTMKNVPFYEEI
TEFVIALNQELERRGLRYGLAAEHAHSCCVLLASERFNKDGKWHTQIDYDRFFELLEKEK
ADGTPFTPEDYTRETEEWALWGNGGFDPNDERFYRKRRNKETPAAES
>A0A7J4KG38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon|TrEMBL
MISTPCKALRSQGYQFFSPDSSAAVKPCLWCKKALKGGDTCYKHQFYGIASHRCVQMTPT
LRCNHRCLFCWRSFEHEYPGERECTPEEILAGIPALQKRALSGYKVSPYVTAERFSEALA
PAHVAISLSGEPTLYSHLPELIGLLNEEGYTTFLVTNGTNPDVLSRCDPFQTYVSLPAPD
RETYLRICRPRDDYWDRIRESLALLGSRRSAVRVTLVRGLNDYAPERYAALLQESGATYG
ELKGYMYLGYSRKRLSREHMPTHEYIREFAGAISELCDYRIADENRASRVVQLERMQ
>A0A150J4B9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MDSYPDNLYITLPAPTKEXYEHICNPQIKDGWXKLNESLELXQXIKTKRRXLRLTLVKDF
NMKXVEEYSKLIEKTNPDXIEAKAYMFVGYSRKRLEVENMPMFDDVLEFCKELEXKTGYK
SIDFAKDSRVILLSRN
>A0A0V1JI79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKRSVNWGRFRLLFRVHQRDFLAGGVVEIQRLYFKNWIAEHIFISFAYKLTTIISFLP
FGIGAIFVENIIIRETNFRQSPFQGGIFGRGILSRYCHCGQLNWISIFQIFFTIINNCII
GHAVFCGNVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSK
FSSVHDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIKE
MLTPTLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSL
ACANKCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEES
STVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVD
AASKESLKEIDRPLTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCGDSKNSK
ITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNVTIFKINGQWYTWIDY
EKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A842MFZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanosuratincola sp|TrEMBL
MNEGIKRAAGTLEGQYRVLRSQGYHIVGRHSAVKTCHWTREAITGGESCYKSKFYGIQSH
RCLQMTPAVSRCTNMCLYCWRVLPHEHGYPLVDGCVEDPPEAIVDGAIAAQRRVLSGYKG
NAKTDPDRFMEAMDPRHAAISLSGEPTEYSMLDGLIREFKRKGMTTFLVTNGTNPKRLGE
IPEPTQLYVSLSAPSEEVYRSVCRPASGASWGRLVESLSLLKSFSCPTVIRMTAVRGLNM
IDPDGYSKIISGASPTYVEVKAYMHVGFSVTRLGYESMPSHAEIVQFARDLAERTGYELA
GEVPISRVALLSRIGKPKKVSASI
>A0A832FQS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum sp|TrEMBL
MESTLSAERYLRAGYRLVGSHSAVAICRWARSAIKGGKLCYKSWYGIKSHRCIQMTPVLN
FCDFACKFCWRMHLPGRFKIPPGWRWDSPAEILDKSIVAQRLLLIGFKGNPAVSSERFLE
AMFPRHLTISLDGEPLLYPKLAELVKEAKSRGLTVFLVTNGSIPVRLRELIRKDAQPTNL
YLSVYGPNREVFEAVADPRIPRAWEMVNESLELLGKFGESRTVVRLTLVRGLNMVEPEGY
AKLISKASPMFVELKGYTWVGESQKRLPITAMPEMRELESFAAKIAEHTGYSVKLTDEKS
RVVLLVRDEEAWEKNLKMVEEWQKLEKERDEKIFEKIVDFTMDDHGYTILRY
>S7ZW50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium oxalicum (strain 114-2 / CGMCC 5302)|TrEMBL
MAEMLSSSKGLLAIWHSWRLTILVVLALFLVSVRMYRRVYLSRSKTTASASIPSSPRNKS
LEISSTSKVSAGTPPPQPTLNNVDAARTDTTKASSGPKRVQGKRPAKTVTGRRAIIQETH
PFFIQPVIFFASLTTTTERYANLLLEELRVSAQAHASLIDREGGLLPPQIHDISYIDFED
YFAAAPKPPSTSPGTQYLYCILIPTYNIDTVLNTLLGHLDEIHNDFRIDTAPLSQLAGYS
VFGFGDKEEWPTEEEGFCSQAKEVDRWMAKLTGRKRAYPLGMGDVKSDAERSLKEWSQGL
QETIMEMLETGGLGEGVPGSGDAVESDEEDVEYLEDMNDESYVVKSKKKSGSTMVDLEDI
RINGQSAAPIPVDFTTAGPAVTTEPQAKEMVPKTSPTYTALTKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPE
LIFAGVKEGHYKKIKMLKGVPGVRAERFAEAMQIRHCALSLVGEPIFYPHINRFLDMLHQ
ERISSFLVCNAQHPDQLQALNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDIL
REKRHIQRTVFRLTLVKGFNVEDEVIGYANLVEKALPGLIEIKGVTFCGTSTSAGAGLTM
KNVPFYEEVSAFVVALNEELQRRGLEYGIAAEHAHSCCVLLASGRFRVNGKWHTRIDYDR
FFELLEKEKADGTSFAPEDYMRETEEWALWGRGGFNPDDERVFRKGRDADSRARKAREIL
GAEMVQGSL
>A0A2A2HZA5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina spelaei|TrEMBL
MPLEEKKENYVEDFSGFQEENRKEDTALLPFDIPDFKTLLKKQGYALAGSHSAVKTCLWL
RHAMNDQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPERIV
EESIVCQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEKRGF
TTFLVTNGTIPEMLAKVSPSQLYMSLDAPDLETYLRVCQPRSPVLWEKINESLSLMKQKK
SRTVIRTTLVKGENLFKPEAYARLMEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVI
EFSQELAKHLGYKVADESEISRVVLLSKDGKKSPVKKGSLP
>A0A395MFJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium flagelliforme|TrEMBL
MDWTNQSSHSRLDSLVDDLVDVWHIHRVPILLTTCVILVAVRLYFQFNGQKTEVVAFKKA
YEEPAKKAYEEPLTPKIVVEEVNPKVTIEEKTPIIEPAEEKKNTKSQGPRRIKGGVARKP
SKKTEEEEDVTRPVVPLVFFSSITTKTAKIAQAYVEELGGKLDEISKQSGRQFLKPETRD
LTEIDFDDYFLTPYKAHVDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSG
LLGYSVFGFGDKENWPTEADGFCFQAKEVDKWMAKLTARKRAYPVGMGDMQSDHEQRLQE
WAKGIEEVIEHAARTGNLGEGLPGSGAAEESDVEDISEDEDDGEVIIEDDATSKKTKGGR
DLDDVEDLGRMIRKDDGSTTRKAPLAVDFTNYGSSTKKSVPQGPKKMVAEESPTYKALTK
QGYAIVGSHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRH
GTNPVGTTWRWVVDPPELIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVG
EPIFYPYINEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRKIDR
PLHRDFWERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVK
GVTYCGTSTSSNAGLSMSNVPFYWEVCDFVKALNKRLEEKGLKYGIAAEHAHSCCILLAS
ERFYVDGKWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDR
KGRKIEAS
>E9E961|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium acridum (strain CQMa 102)|TrEMBL
MSAVCDKTDPLQGVFGGLAGARFDEPKDIVELWHGHRTPIIICALVVLVAIRIYIHKIEE
AEPLRALPKQFEKRIEPSSTNKPPSAVSSEKPIAKSNGPRRIKGGIAKKPATEEKNEHDK
SRPIKTMVFFSSVTTKTEKIAQQYSSTLEKSVGQLSRETERQFLKPELHDLAEIDFEDFF
VSPAKTVEDAYLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLAPLLGYSVFGFG
DKEGWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFEEWSSGVQEVIA
HVASAGSLGEGVSGSGDAMESDAEDVAEDDDGEVLIEQDISGDDKESSRPLDDVEDLGRM
LRTSDGNANANGKKAPLAVDFTSYGSSSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFY
PHINEFLAMLHAEHISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRD
FWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYC
GTSTSSNAGLSMSNVPFYWEVCEFVKALEERLKAKGLKYGIAAEHAHSCCILLASERFLV
NGKWHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRK
IENVVVREAPPPESW
>A0A178B2J2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stagonospora sp. SRC1lsM3a|TrEMBL
MSSLDALAQLPAELLLIWHNHRISLLFSAVALAAFVRLTLYARRQRQKVSASPIPGSPVE
KKAVELRPEWLPENTTIDTSTLNVDDHVEDVTGAVTTIAKTKKGPKTVKGRKTPKKALVP
APSFDHTTDKIQPVVFFQSLSGTTERYATEFAKVLTEWTTGCDQSTSFLEPQVHDISYIE
YDDYFISPPKLEANVKQFYIILLPTYNIDTVLDNFLENLQETHNDFRIDTAPLRSLLGYS
VFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDTKTAAADRLQEWRLGV
QEALVEIAEGRGLGDGVPGSGDPAESDEEEDVEDNGQSTRVDEIEELGAMVDSDVATPIP
VDFTNYKAKSKPLIKSTAAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDGIT
AAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLNIMHSNRISTFL
VCNAQHPAQLASLVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACLDILRNRRYEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPFYE
EVAEFVTELEKELNSRGLTYGIGAEHAHSCCVLLADKTRFMPNGKWATRIDFERFFDLYE
GKVEGTRMEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDQRVYRKGKGPKVEEINDDA
PTTTATTKVKNEALDF
>A4RUJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ostreococcus lucimarinus (strain CCE9901)|TrEMBL
MYLKNVRYAVFGCGNREYGDNFNRAGRELDAQLARMGGERLARRCDGDEASGRMEKQFEE
WGEKVIRRLSNSTASSGDDAAHSRVGVAEERDQSEYASEGEDDEGGASAAGSEDGQDMED
IAEGEGGEKKEMVTDALRGALTKQGYKILGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCTFCWRHHTNPVGKTWRWQMDDPLELVEAAVSEHCKMVKQMKGV
PGVLPEKLEEGMNPKHCALSLVGEPIMYPEIGKFVSELHSRKISTFLVTNAQFPEAITNL
PPITQLYVSVDAATPETLKAIDRPLFADYWDRFIGSLTSLKDKQQRTVYRLTLVSGWNME
EVAAYAKLIDLGQPDFIEIKGVTYCGSSDASSLTMKNVPYHKDVCEFGEAIVNLRRRENG
EEEYGLACEHAHSCCILLARTDRYKIDDEWYTWIDYDKFQTLVASGEKFKALDYIERTPS
WATYGAEEAGFDPEQTRHRKVRNHPGKLTSDEPPE
>A0A851BSE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Picathartes gymnocephalus|TrEMBL
LDVSMDTWSHFHACLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPKSHGNPS
SPGGAADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINM
GDYDPEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLR
YAVFGLGNSAYVDHYNTVGRRMDRWLWMLNASRIMTRAEGDCNVAQSKHGSIEADFEAWK
AKFLTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHEMSEHENTEAEELFETSS
EEEAGVTDSVIDVEDLGNIMGHMKKAKVLLLDGDVECHSGYHLVYFVCQFLQAKLNCLMV
FALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKLDQPEVILQEAMEKHQNMIRQFKGVSGVRAARLEEALAVKHCAL
SLVGEPIMYPHINSFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLR
RIDRPLFKDFWQRFLDSLKALAEK
>A0A3B3TP42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia latipinna|TrEMBL
SLLLSVQINHTKDSGSKDSGLKVQKAAKNEVSSDEDADVHVSGVKIFYGSQTGTAKGFAS
ELSQEVQALGIPAEVMDMKDFDPDDRLADEVSKSVCVFLVATYTDGRPTQNAEWFCKWLE
EASTDFRYGNSFLKGLRYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSARRVLSRGEGDGN
VVKSRHGSVQADFRAWKVRFLSRLRALARGEKKSCSGNCKSGASCKNRKKHGAPEEEEHG
SEVTGNLPRIFVWLLKYDETNLHFSLGYNQIKGREMITPALREALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPAEKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLAAKHCALSLVGEPIMYPEINTFLR
LLHSHRISSFLVTNAQFPEEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDC
LRALGEKKQRTVYRLTLVKAWNVEELQAYAELIALGQPDFIEVKGVTYCGESSASSLTMA
NVPWHQEVVAFVQQLADMLPHYQIACEHEHSNCLLIAHSKFKVNGEWWTWIDYDRFQDLV
QAHEDSGGQQTFSALDYTAKTPSWALFGSNEQGFDPADTRFQRRNKTKDISGC
>A0A0V0G8U9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triatoma dimidiata|TrEMBL
TNKESVIRNSFIKKECKENGMIIPVKVLNVYYSTQYGRTKALCEQLPSISAIKINIFEMA
KVEAEEVLLRDANAPDIISLIIIPTVGDGKPPDNGSWFCKWLHEAATDFRIDKELYKGLH
YAVFGLGNSAYGENFNIIAKKLDSNLKKLGAKRILPLTLGNEDASNSINGSLEADFKSWL
QELKELIKHSEISSSWLTQKVSNEDSSDEEENDKDNVVDVEDLVKITNKKESLKEKEMIT
PSLRQTLSKQGYKLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIQSHRCMETTPSLACA
NKCVFCWRHHSNPVGTEWKWKTDKAEDIVNDALRNHYNMIKEFKGVPGVLLPRFEEGLNA
KHCALSLVGEPIMYPEINRLIRLLHERQISTFLVTNAQFPEAIANLDPVTQLYVSVDAST
EESLKKIDRPLFKDFWKRFLDSLKELSKKGQRTVYRLTLVKAWNFDEMQNYANLVNLGNP
DFIEVKGVTYCGGDNTGPNKLTMANVPWHEEVVSFVQQLTSLLPDYEIASEHEHSNCLLI
AHKKFYIAGQWHTWIDYDRFHILMQSYCKTEGNQTFTTLDYTSPTPSWAVFGSKERGFDP
IEKRWFRKSKKDISGC
>A0A133V777|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA261F17|TrEMBL
MMLSIEAKTNLEDSGYRIVGQHQHSAVKTCRWTKKSILDQGFCYKQKFYEDIHGIKSHRC
LQMTPSLPFCDHRCIFCWRNVDLNSPTWQGEADEPTEILDGAIEAQRLLLSGFKGNPNAN
KKKWEEAQNPNLCAISLDGEPTLYPKLSELIEECHHRNIVPFLVTNGQHPEHLEEISEPS
QLYISTVAPDEKTYTQICRPLVTNSWERLNESLELMPSFNCVKVLRLTLVKGWNLKDLSG
YAKLVEKAEPDYIEPKGYMFVGHSRKRLQMNNMPTHEEIAQFAEKLEKLTGYKITDESEP
SRVVLLSTE
>A0A0G2E2Y0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaeomoniella chlamydospora|TrEMBL
MDLSSDQVWTVALADHIDWFLGLWHQYRMPAVFGIAAVLLAARLFLRPNRSKTPSSASIP
PSPTNTAAIDKVLPEIADLNRDSVRQSIPASQAPKQSVAKGPKVITGRKPVRTSSPESQK
HTSFSIQPIIFFCSLTGTTEKLAGEVQGSLERFAERVGERILKPQLHDISYVEFDDYFIN
GPPKQKSFENIKHVYCILIPSYDIDTILNTFISNLEEIHHDFRINTAPLSTLLGYTVFGI
GDKEGWPTEAQGFCSKAIEVDKWMAKLTGRKRFYPVGTGDVKGPLMESLSEWLTGIKGGL
MDISESGSLGEGVPGSGAPVESDEEEFEEEFPDPKPKKRQKVSDISDLEDVRGPSSDASP
RELPIDFTTYSKTASPTPKEMVPKSSPTYTSLTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDEPELIFTGAKEG
HYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPHINKFLDLLHGERISSFLVC
NAQHPDQLEALTRVTQLYVSIDASNRDSLKKIDRPLHRDFWERFQKCLDILREKRFVQRT
VFRLTLVKGFNIDEEAEGYADLVAKGLPCFVEIKGVTYCGTSTSAGAGLTMANVPWYEEV
VEFVEALNASLAKRGLEYGIAAEHAHSCCVLLASKRFHIGGIWNTLIDYNKFFDLLEGGD
EFTPEDYCAPTPEWALWGKGGFDPADERVDRKGRKIENADPRRGVPQPKVEDVSF
>A0A7K3Z966|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crenarchaeota archaeon|TrEMBL
MPQQLIKVFEKQKYHIIGKHSAIKRCGWLYRTLVQNRPCYKEKFYGINTHQCIQMSPAAF
YCTQQCLFCWRAQNGDLNIKFDELKFPEWDAPEDIANGIIVEQQKLLGGYRGNPKTIPQK
LREAYRPRHVAISLTGEPTLYEPLGELISVLHSKNFTTFLVTNGTVPERLSKLSQEPTQM
YVSVCAPNEKVYKQVCRPQISDAWDKLNMSLSSLSSFNCRTVIRMTLVKGYNMQDIEGYA
KLVEKANPDYIETKAYMHVGFSTLRLSFDNMPTHKEVNEFAKQLANRTGYTIVDEASDSR
VVLLSKKGKPVRFSV
>G2R2J1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermothielavioides terrestris (strain ATCC 38088 / NRRL 8126)|TrEMBL
MFPDSRGVSPSIMSEVASYVLELWHEHRIPIIMSTLFVLSLLRIYLHSTEKREKLLVIPK
IYEKVPPNLVAGAEKKSKTEVRKDDSEGSESTGTGNEKWRAKDGPRRIKGNASRKARSRA
ESGREARRIQVLVFFSSLTGSTEKNTQLLAQELATALGCTAEEESGRTFLPPRVLDLAEV
DYDEYFIAPPKPESEQTDYFYLFVIPSYNIDSINDNFLEHLRETHHDFRIDTSPLAPILG
YSVFGFGDREGWPTEDEGFCFQAKEVDKWMAKLSGRKRAYPLGMGDWKRDGKQRLSEWRT
GLVDVLKQVAQTGSLGDGVPGSGDPIESEDEGEAEDDGEVLEETVDAKGAKRSSGGIEDV
EDIGRIMELSRADGSREKSAGPLAIDFTTEGKSATKKSVTVAIKEMVPKNSPTYTALTKQ
GYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPQLIFDGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPHINEFLGLLHGERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNRESLRRIDRP
LHRDFWERFQRCLDILRERRFRQRTVFRLTLVKGFNIEDEVEGYADLVERGLPCFVEVKG
VTYCGTSSSSSAGLTMANVPFYQEVCDFVVALEKALLKRGLQYGIAAEHAHSCCILLASE
RFRVDGKWHTLIDYDKFFQLLEEKGPDGDFSPEDYMGPPTPEWATWGNGGFDPRDQRVDK
KGRPIEAN
>A0A6J5TQE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus armeniaca|TrEMBL
MSLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSSSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNGLGFDLVDPNHYEPEDLPKETLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGAVEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNGVGAECEAESFDGSDEDDEEEDDLESEV
VDLEDIAGKGPSRRRTVTVTKTNGTVNGQKEMVTPVIRASLVKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPL
EIVNSAIDLHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHR
RRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSL
KEKQQRTVYRLTLVKGWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPW
HADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSS
GRPFDSKDYMAATPSWAVYGAEEGGFDPYQSRYKKERHHRSNQ
>A0A8C2Z9B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyclopterus lumpus|TrEMBL
MSVWHNRLYLYSAAALVFGIWFSVKVALKKNKFFKDSKAQKSSDHSDRDAVAAHVSGVKI
FYGSQTGTAKGFAEELSEEVKTLGVPAKVIDIRDYDPDDQLADECTNKSVCVFLVATYTD
GQPTENAEWFCKWLEEASTDFRYGKTYLKGLPYAVFGLGNSVYVGHYNTVGTNVDKWLWM
LSAVRIMTRGEGDCDVVKSRHGSIQADFLAWKVKFLIRLQALVKGEKKSYSGNCKTKGSC
KNPKKDGQEEEEETTALQNSSEDELVESSSDEEESGLQDEEKSGSVVDMEDLGNIMSSAK
RAKVFTALLTCFVLSFPAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILHEAMEKHQGMIRQFRGVPGVQPE
RYEEGLAVKHCALSLVGEPIMYPEINAFICLLHSHRISSFLVTNAQFPQEIRNLVPVTQL
YVSVDASTRDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLSYS
ELIALGQPDFIEVKGVTYCGESAASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEH
SNCLLIAHTKFKVDGEWWTWIDYERFQDLVQVQGESGGQRGFSALDYMAKTPSWALFGAN
EQGFDPTDTRFQRRNKTKDISGC
>S0DRW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILIAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYVEDFCGKLDELSKLSGRQFLKLELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>Q12V99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)|TrEMBL
MSLKDKEDLMILPEITDFETLLKKQKYSLAGTHSAVKTCLWLSRSIKDQGECYKSKFYGI
TSHCCLQMTPTLRCNQRCLHCWRPTEVEVSLPNNWDSPVEIVGSSIKAQRKLITGFGHSA
PRERWIEANEPKHVAISLSGEPTLYPYLPELVEEYESQGFSTFVVSNGTVPEMMEKIEPS
QLYMSLDAPDKETYEKVCLPKSPALWDKINRSLEILGTKNNRKAIRITLIKGLNMFDTAG
YGRLIEKADPDYIEVKAYMHLGYSRGRLPREAMPAHDEVLEFAKELAGHIGYSVADDVEV
SRIVLLSKDGKVSDLE
>A0A1F9YKB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon RBG_13_31_8|TrEMBL
MNNEFRNILEKQHYGIVGDHSAVKVCHWMRQSLLFDRECYKQTFYGIKSHRCLQMTPSVN
QCNHMCLFCWRHQGFSEKDFKKIDDPRFILDESIEMHKKLITGFKGDERCDQKKWKEANH
PNMLACSLSGEPTLYPKLGEFFKECKKRAITTFLVTNGTNPKTIEKLDNLPDQLYISIVA
PNEEIYKKICSPLTSDTWKKIIQTLELLPSLNTRTVIRHTLVQGWNMDEKYIKQYYKLDE
KAEPMFIEPKGYVFVGYSRKRMNLSNMPSHKSVHDFGATLADYLGYKFEMEKPDSRVVLL
SRKEKMERFDK
>A0A812RMW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium sp. CCMP2456|TrEMBL
MGSCASQHQSADGHRFQDIEDLDLLFGSKPTTSSPSVGPAVPKGGVEAKTADAFWVKRLR
KERVRPLYRSGELKAVHLELTTRCNAACPQCPRNLQGGAENPVLAAHHSELSLEDVRAIL
PPGFLRQLRKVYLCGNFGDPAVAQDCAEVIRYLLSVGGPRVGLFTNGGMRSPVWWEELGS
IMQPPDRAFVRFAIDGDEATNHLYRQHVRWERLMANVDAFLAAGGNAEWDFIVFEHNEQQ
VEAMRSLAEQKGFTKFNAKKTARFIDKGRGAVKPSVPVKDTSGSVVRTLRPPANPAWQNE
AALESVQKAVEKYGSIEAYYDSCEISCKVAKEKEVYISADGLAFPCCWLAAEMYRADLQN
SGREVVRLAKAAFPQEGLHALSALPRGVGAAVDRRAGLFQQLVPAAMRQPSLREGRLRTC
SGVCGVEVNAFTKQFAGAAQPLDPVRRSRAASAATVAPEPVEGSPVEVWYGSETGTAEHL
ALRAAEALGSEAAVSAPPPWDQVEARLRGCRALVLVLATWGQGEPTEDAQGLFRFLRERR
GEAKGVFPALPVAIFGLGSSLWPDFNAAAREAEELIRSLGAPILIRLGEGDAAKGHLDSD
FDAWLQELLVALQKLGLDSRGGPPRVHRGTESASIVPMTVVRVTRLAPRDPVARYFEVQL
RGALAHGVGDALGVLPPRGGFAGARRPRWYTIASAPTNSDDQVLRLLVREVSGGVCSPYL
CGLRPGDVVECLGPRRPSPLWAAWEARPSSTSRLLLVANGAGLAPFLALLEQLSVSDSRP
LLYLYLGCRERPGGLLYEERLEALEAQGALQRLSVAESRPLGAAKAQRPWVQDVLKVESE
EVGQLLFGSPTEPGIGLMLVCGSAAMGCAVRDVVSAIAQNHGTSVEALEAEGRYAAELW
>A0A673BTM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
GSFKNIDIQNYIKVENRLYLYSAAAVFVGIWISLKMGLKKQSLSADTAPKVYKAEKKNGC
SDRDAVVHVSGVKIFFGSQTGTAKGFAKQLSEEVQTLGLTCEVIDMKEYDPDDRLADECT
SRSVCVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYAVFGLGNSVYVGH
YNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVKFLNRLQNLVKGD
KKSCSGNCKNGGSCKNKRKDGHGQEEEEDEDLMESSSDEDESGLQEGKKSVVDMEDLGDI
MTSVKKAKVKKEKEEEELSKLNGVKKVEDEGERREMITPALREALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPPEKILQDSLEKHENMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLR
LLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFQDS
LRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMA
NVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELV
QVHEDSGGQQSFSALDYVAKTPRWALFGAEEQGFDPNDTRFQRRNKTKDISGC
>A0A7L1F301|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sylvia borin|TrEMBL
LDVSMDTWSYFHTCLASIWLHRFYIYSAVAFGISLWIVFQFTTTRTKRKKSHGSPSSPEG
ATDKLRNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYD
PEDGLVEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSLLQGLRYAVF
GLGNSAYVDYYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFL
TRLQVLCKGERKPCSGKCKKGKCKSSGKQSKESSDLEHGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNVMGHMKKAKREQELEEEAAGSGRKEEAERREMITPALRDALTKQGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPI
MYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLF
KDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDFVEVKGVTYCG
ESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTW
IDYSRFQELVREYEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDI
SGC
>A0A662NPQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococci archaeon|TrEMBL
MDVKPNMPEEITNLFKKQHYALVGHHSSVKLCHWLKESIKNDRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPRPFDDPAFIVEESVKAQRKLLSGYWGVKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEPEVLENMMKEN
KLPTQLYISLTAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMH
NPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVENLPEYHIE
DEYPPSRVVLMMRDDIRKADRVIKH
>K8FF00|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bathycoccus prasinos|TrEMBL
MVNTTTTQKVLLVAFSVGFVLCEYRWYHAKEKKRVEGIFPKDDDDDGVKVNKAKKTTPAE
KKKKQKREQKQSFWKEETEESESDNDDDDDSVRIFYASTSGNARSLAQKLGADLDRTVID
LSEVLEPEKTFANEEEEEEGILKMERKKVLKCAIFVVSTTTGGEIASECKHFMKWCEEQA
YDERAGWSYLKELKFCVFGVGDSQYEENFNRAARMIDKHFARMGAERILRKFDGDESSEV
EMKTQFEKWTEKLKGRVFPPTTAEKRRQKKKKEADEENVKEEDEVENDDDDEEEEDEVDR
SDTESYFSGSEDDMDVEDVGGDGSARDPNAPKPEMVTPKLRKALTKQGYKILGTHSGVKL
CRWTKAMLRGRGGCYKHAFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKEWKWEMN
PAEDIVNDALGQHRKMINEMRGVPGVTEAKLQEGMDPRHCALSLVGEPIMYPEIGKFVSL
LHEKRISTFLVTNAQFPKAIEDLPPITQLYVSVDAATPETLKAIDRPLHSDYWDRFVGSL
SSLKTKPQRTVYRLTLVAGWNLAEAEEYAKLVKLGEPDFIEIKGVTYCGSSDKSASALTM
KNVPYHEDVVKFSQEICRLTNIEQEEKGASSYELACEHSHSCCVLLARTKDYKIDGEWHT
WIDYEKFQDLVAKGEPFEAKDYICKTPEWSVFGAKEGGFDPNQTRVRKIRNHPAKNTTTT
>E1QSE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulcanisaeta distributa (strain DSM 14429 / JCM 11212 / NBRC 100878 / IC-017)|TrEMBL
MEKIEQAIKESLKYHTIGEVNGRIRIRITDETKTKLIKASYGIYNHSTVELCHWTKSALV
KGQSCYKFKFYGAPAGGSHRCAEFSPVGMICSNRCVYCWRPTESFDSFVPSEGLVDDPEE
LIQGILKERYRLLTGYFGNPKSKERAKEALVPTHWSISLSGEPTLYPKLPQLVKYLKSLP
STKSVFIVTNGEHPEMLERLQREDALPTQLYLSCNAPNKELFYRINVPVMYREDAWERWL
RSLELLSKLNTRTVIRITLIRSLNYDFKYIPEFAKLMLIGNPHFIEVKSYMHLGHSTFRL
KRSDMLRHEEVREWAMRLLEEINRLGGNFRYMDEDEPSRIVVLQNMSRYVDRWIVKPEDQ
AKIK
>A0A0W8DJ62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora nicotianae|TrEMBL
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A7T9HGK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolinea sp|TrEMBL
MASKHSQPCKALRSQGYQFVAPDSSAAVKPCLWCKKALKGGEKCYKHQFYGVESHRCVQM
TPTLRCNHRCLFCWRSFEHEYPGERECSPEEIVARIPDLQKRALSGYKVSPYVTAERFSE
ALSPRHVAISLSGEPTLYPYLPELIDLFTHQGYTTFLVSNGTRPWVIDACRPFQTYISLP
APDRESYLRICRPLEDCWDLIGESIALLGTRRSAVRITLVQGINSSAPGKYAKLVQDSGA
TFVEVKGYMYLGYSRKRLGRENMPRHADVRAFAGSIASHCDYRITDENPASRVVLLEQDP
>A0A672LSV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus grahami|TrEMBL
MVDPISPLLYKSVKNQELSPETEKVLYVSGVKVLYGSQTGTAKGFAKELAGGISAQGIQC
EVIDMKEYDPEDRLAEECTSKMVCVFLVATYTDGQPTESTEWFCKWLEEASTDFRYGKTF
LKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQAD
FHAWKTKFLNRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSEEELME
SSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWSETNHAVMNHLNQVK
CVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIR
SLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWN
VDELKAYADLISLGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDY
EIACEHEHSNCLLLAHHKFKVDGKWWTWIDYERFQELIQEYEESGGTKSFSAMDYMSKTP
SWAIFGAGERGFDPLDTRFQRKNKTKDISGC
>A0A031LQV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Acidianus copahuensis|TrEMBL
MTISSFRIDTLSKIMSEMEKQKYHIIGSHSAYKKCHWTHEALTSGRYCYKGKFYGIESHR
CVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDETKMPILDDPEYIAERSIEEHKRAVSGYF
GHEEVDKEMAKEATKPAHVAISLTGEPTLYDKIGELISEYHKKGMTTFLVTSGVRPDVLA
NLEEEPTQLFVSIQAPNERKHKMINRPIVPNAWKLFMETLEILPSFSSPTVIRMTMIKGY
NMSEEDAKEFAELIKIAMPTYIEVKAYMHVGPSTLRLTRDAMPRHTEVKEFANILAKFTG
YNIISEHVPSRIVLLSKIDRPIQIGNAWTDRWNWSTKDMDDDINGEYKEAETGCTEG
>A0A094JZN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4520|TrEMBL
MADNDYLGADIASDTMENYLMVLWHTYRIPLILTALALLLITRTVLHLKVGREKIIYTPP
PTPSEKAPLATNLQREQLVEKAPVSAEVKKAAGPKRVVGKVTRKKSPLRDQPESKDVKFQ
VLVFYSTLAGSTERTAQALTTKLADTLKAGAESSQYEFLSPIAHDLAELEDYDEYFLNVP
KSEDGEPDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGD
REGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQDRLDEWRQGVEDVLQN
LGQTGNLGEGVVGSGDADESDVEDADEDEAEVQSDGAVKLKRKSKKKATSSMDDVEDIGR
ILQKGQNESEDQDEGAIDFTTYGKKTPKPVAALKEMVPKGSPTYNALTKQGYTIVGSHSG
VKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRW
VVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNEF
TAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQ
RCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSG
AAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWHT
RIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVDGE
EVEKEVEAKEDKPVLVEI
>N1QDA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaerulina musiva (strain SO2202)|TrEMBL
VLQLWHAHRPELLLSAGVLLAIVRLVLHWRSTKAKPLLTPPLGTPIDEKPFPLPEKQALQ
DQPVPETAATQPTKSKGPKRVKGVRTVKRKDSPVQTISQIQPYVFYYSLGGSTQAYAERL
AATIEPNDRVRAPIVHDLTEIDYDDFFISAPKLVTDGLAAFYYVLLPSYNIDTELSNFLS
HLDETHHDFRIDDQSLSGLAGYSVFGFGDRQEWPTEQEGYCSQAIEVDKWMAKLTGRKRA
FPLGMGDVKGDDIELRLEEWRRGVYSIVEDLSTGQGLGEGAVGSGDPAESGDEISEDEDD
GEVLFPVQGKISKRTTTDDLEDIKAPIPVDFTTTSTKKASAPAVPKAMVPKESPTYSSLT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMEATPSLACANKCVFCWR
HGTNPVGTSWRWTVDPPDQIFQGMTAGHYQKIKQLRGVPGVRAERFAEGMRIRHCALSLV
GEPIFYPHINELLAMLHAQHISSFLVCNAQHPDQLASLGPVTQLYVSIDASNKEQLRKID
RPLHRDYWERFTKCMDILREKRFTHRTVFRLTLVKGFNIDEEAQGYADLVERALPGFVEV
KGVTYCGTSTSKGAGLSMENVPFYEEVQSFVLTLEKELKKRGLDYGIGAEHAHSCCILLA
DKTRFWTPLKSSEDRQRTAYEGPGRYHTLIDYPAFFKCVESGKAFGPEDYRGGETAEWAL
WGNGGFDPRDERVDRKGR
>A0A8C2RSK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capra hircus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTAPKASQD
LMMNGYIFRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPVAMINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAKWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALCKGERKRCRGNCKKGKCESNQRGSEAAEPGSHTQEELHHGDAEEEEPFGSTSEEESD
TEDHQSQNSVIDVEDLGKIMDHVKKEKREKEPQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTIKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDDLQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKEI
APFLLLIPGLQNRRISCSCIAVVLLLYQKTAREEIGIACPFILK
>A0A7K4KTR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crypturellus soui|TrEMBL
LDVSMDPQNFYTCLMSLWLHRFYIYSSVALGVSIWICIQFFTNKIRKKKCNGNPASAEAT
EDKLVNGYVTSKVKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVISLNLSAEVINMGDYDP
DDSLTEETTSRNICVFLVATYTDGQPTESAVWFCKWLEEAANDFRFGKMYLRGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLSANRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLS
RLQALCKGEKKPCSGKCKKGKCKSQGKQSRESSDHEHGTSEYVNTEAEEFFETTSEEESD
AEKAGETNSVIDVEDLGKIMSHMKKAKVLVLQLKAIAQLTSSFSGYRLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
MILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINRFLKLLHQ
QNISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLTAL
SEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSASNLTMANVPW
HEEVVRFVQELADLLPDYEIACEHEHSNCLLIAHKKFKINGEWCTWINYDRFQELVRDYA
RSGGSKTFTAADYMAKTPPWALFGSRERGFDPLDIRYQRKNKTKDVSGC
>A0A7N8YI98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mastacembelus armatus|TrEMBL
MPFLPPASQNEPGPSERAFMSIWHNRLYLYSAAALVFGLWFSLKMARKKVSYALLDIFNA
LGFAKQLAEEVEALGIPAQVIDMKDYDPDDQLADECSGKSVCVFLVATYTDGQPTESAEW
FCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYIGHYNTVGKNVDKWLWMLSGMRIMTR
GEGDCNVVKSRNGSVQADFQAWKAKFLKRLQALAKGEKKRCSGNCKSEGSCKDKRKDGQR
KEQERAALQNNSSEEDLIGSSSDEDESGLQDDKKVVDVEDLGSIMNSVMKAKLYCYTTQI
KQNLLVCLLVESLILLTHCTLMFAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHQCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQNMIRQFRGV
PGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSHHISSFLVTNAQFPEEIRSL
VPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVE
EMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQTFSALDYIAKTPNW
ALFGAYEQGFDPADTRFHRRNKTKDISGC
>A0A7N8XQL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mastacembelus armatus|TrEMBL
MARKKKSFSKDVSPSVSKAVKNNKSSDRDAVVNVSDVKIFYGSQTGTAKGFAKQLAEEVE
ALGIPAQVIDMKDYDPDDQLADECSGKSVCVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYIGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSVQADFQAWKAKFLKRLQALAKGEKKRCSGNCKSEGSCKDKRKDGQRKEQERAALQNNS
SEEDLIGSSSDEDESGLQDDKKVVDVEDLGSIMNSVMKAKVMCAEFGLCGSGSERCLLVE
SLILLTHCTLMFAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHQCMETTPSL
ACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQNMIRQFRGVPGVKPERYEEG
LAVKHCALSLVGEPIMYPEINAFIRLLHSHHISSFLVTNAQFPEEIRSLVPVTQLYVSVD
ASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAL
GQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLL
IAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQTFSALDYIAKTPNWALFGAYEQGFD
PADTRFHRRNKTKDISGC
>G0TZG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma vivax (strain Y486)|TrEMBL
MALGSMLAFMNSLLYAWLPVAFGWFVALLRFLLRAGRVHEVASDKGAAVLHNGNGKGECG
CSCVAGSVVREPKKILIAYATQSNTACKLSHQLFSTLSSALLERVSVCASGSVQDANGPF
KENCCQGDRADMGTMPELRVLQLTEHGRQCSVEQLMEESAYGLVVFFVSTHSGGTAPESS
RSFAMMLKDAYMDFRVPRDALARVRFAIFGLGDIAYGAEHFNRFAKDLYTWCKGLGGKFV
VPPVYASEANMVSLYNVFSVALVKWVGRAVFTPDGVVVKKKLEQRRQAGGKKRGTEVGDS
ANRGAGESRQRSKQIANDSDGEEEKVAAAASALNGGMVRPGDANEQEELSDSGGDDINSS
NNNDADDTSADDVEDIVMNENDTGGGTSGEPPEMIYPRLRENLQRQGYHLVGTHSGVKLC
RWTKAMLRGRGGCYKHTFYNIASYQCMEMTPSLACANKCVFCWRHHTNPVSRSFRWKVDP
PLKLVEEGLAGHRRMIKQMRGVPGVTPERLEEAMQVRHCALSLVGEPIMYPEINAFVDLL
HERNISSFMVTNAQFPEQLRDLKPVTQLYLSIDAPTPEELQRVDRPLFEDYWERCLACVR
ELRRKPQRTVFRLTLVNQYNMENVAAYAELVRLGWPDFIEVKGVTYCGTSGASTLTMKDN
VPRHSEVVSFCEVLCKQLAAYTEPRDKRLWLGSETLNTSEKEEEASVCGSSEGGETTATS
GEQRNSESEGAAYGPYRIACEHEHSCCVLIALRRFLVHGVWHTWIDYDKFYELVRSGRKD
FVAAEYAAPTPSWAVFQSEEKGFDPTQVRVRRKCGKPLVITSGC
>A0A8D0N520|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMGRVKKEKREKAQQEGETGVLRSAVKNEASEPRAMITPALRE
ALTKQVSQSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRW
KMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRF
VKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFL
DSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLT
MANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQE
LIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRYQRKNKAKDISGC
>A0A8C0JY97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus dingo|TrEMBL
MNFVQLFILKGKKSQEKSVPKATGDLMTNGCISLQNKEVFVSGVKIFYGSQTGTAKGFAT
SLAEAVTSLDLPVAVINLKEYDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWL
EEASSDFRFGKTYLKGMRYAVFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDC
DVVKSKHGSIEADFRVWKTKFLARLQALQKGEKKPCDGNCKRGQCESSVEEEPSESTSEE
ESGTEDHQNLNSVVDVEDLGKIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSERRTMITP
ALREALTKQGENPQEVLSHGLAPVFGPGRDPGDPGSNPTSGSRCMEPAPPSACSLEFLPL
VLRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKI
GREWWTWIDYNRFQELVQGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A8D0IVV1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIEGSLCVWSEDFLWFPDWHSKG
VSILAEAVTSLDLPVAVVDLKAYDPDDYLLEEVTSKSVCAFLVATYTDGRPTESAEWFCK
WLEEAASDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMARGEG
DCDVVKSKHGSIEADFTAWKAKFISRLQALRQGERKPCSGNCRKGKCESHQRGTGQAEPG
PQAQEGFRRRDAEEEELLGSTSEEESGSEDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQ
EGETGVLRSAVKNEANEPRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPDIILKEAIENHQ
NMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRFVKLLHECKISSFLVTNA
QFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRL
TLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVSEL
VGLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQELIQEYEDSGGSKTFSAK
DYMARTPHWALFGASERGFDPKDTRYQRKNKAKDISGC
>A0A287AAJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRYQR
KNKAKDISGC
>A0A7J4LBE4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteria archaeon|TrEMBL
MTEKYEEILKRQGDHIIGSNSHSAVKLCHWLKKSIIDQGECYKSKFYGIASHRCIQMTPY
IGCNQNCIICWRPTGLSASFGRMDSPEEIVDASIKEQIRLLTGYKGSYRADIAKYWEAVE
PRHVAISLIGEPTLYPYLDELIDVYKRRGLTTFVVSNATRPDVIEQINPTQLYLSLESFN
EEMYKRLCRPIKKDGWNNVLKSFKILSEKDCRTVLRITVIKGMNTEPEKFVPLINMASPD
FIEIKSYMHLGYSRQRLDRDRMLDHEDIKNFSYVIDKETDYKVTDESFESRVVLLSKDNG
KNRFIG
>A0A7C4BFN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MRPIALLTDFGTKDHYVAAMKGVILSINPDARIVDISHEVRKGDIASGAFTLLQASRTFP
AGTIFVAVVDPGVGTGRKCLAMRTRNHFIFLAPDNGLLSLVAQQYGVEEVREISNPQLMR
PEVSATFHGRDILAPVAAWLSLGKGLEEVGPKLETYSSLEFPTPKLSGRRILGSVLHLDD
FGNVVTNIPSSMVPYTPGQTLLVEVAKKRIPLTFARTFGEVGRGEALAYLGSSGFLELAK
NLGNLAREMRIETGMEVRITPAEVPVHQLRSYLKQGYRLVGENSAVKICHWTKESLLDGE
GCYKMKFYGIRSWRCLQMTPCLFNCTHRCLYCWRMVEATSPQARAEDDPSEMIEEAIRAQ
RELLSGFRGNPKVNLERWREAQEPRHAAISLAGEPTLYERLSELIGEFKRRGFTTFLVTN
GTMPERLEALKEEPTQLYISLSAPDEETYRRVCNPLLENGWSRILESLRLMRGFSCRKVI
RLTMVKGLNMIKPEAYSKLILEASPDFVEVKAYMDVGFAKKRLGLQYMPSHEEIRSFAKQ
LSLETGYQYLHESEISRVILLKK
>A0A662S4Y9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MIIFTPAYHFYRASTPRERIKMLSKVVKVPDHVRELMEKQGYKLIMNHSAIKPCHWFRKA
LLEGRLCYKNKFYGIPTWRCLQMTPTASFCNLQCLYCWRLNVSDVPPNFRWKEVPDDSSV
WDDPEEIAEESINVHRMMVQGYKGVKVFKKEWVYEAEKPKHAAISLTGEPTLYPMIGGLV
EAYSKRGMTTFIVTNGTLPERLENIEREPTQLYITVPAPNRKLYMEITRSLWSDAWERLN
ITLSLLQSFSSPTVMRIPLIRGFNMDDKTIEEFSELVRKYQPTYVEPKAYMWVGYSRRRL
SRENMPSHDEVRRFSEILVNLSGYKILDEAPESRIVLLSRLDKPIRFQYS
>G1RS61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nomascus leucogenys|TrEMBL
MKLSVCVILNLDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQDRNLQ
EKSVPKASQDLMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAI
INLKEYDPDDHLIEEVTSKNLCVFLVATYTDGRPTESAEWFCKWLEEASIDFRFGKTYLK
GMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFR
AWTTKFISQLQALQKGERKKSCGGHCKKGKCDSHQHGSEEREEGSHEQDELYHRDTEEEE
PFESSSEEEFGDEDHQSLNSIVDVEDLGKIMDHVKKEKRETEQQEEKSGLFRNMGRNEDG
ERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAER
FEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLY
VSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQ
LVSLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVQIACEHEHSNCLLIAHRKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A7C3XG37|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKVEPERVYLKPSSQTLDPAFATILRRQKYQIIGGHSAVKKCRWLHKSLTADEPCYKEKF
YGIKSHRCLQVTPAVAWCTQRCLYCWRIQEGESDMSWGLEAPASWDPPADLAAQSIGAQR
RILSGYKGQVAEGRVDPKKYSEAMEPKHAAISLTGEPTIYPFLDGLISEYHRLGLTTFLV
TNGTRPKVLAELQEEPTQLYISLSAPNLERYIHICRPNSPGCWQSILETLDLLKSFSCPT
AVRITLVKGYNMEDLQDYASLLSRAEPTYIEPKAYMYVGYSRSRLQFSNMPSHREVHEFA
LRLAEYTGYKIIDESVESRVALLSRLEKPIRVM
>A0A523WYS3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVPEELRKVYRKQGYHLVGGHSAVKTCHWVRRSLNTGGLEHCYKQRFYGIPCHRCLQMT
PSLGRCTQSCVFCWRATPENIGVQWEQTRFPEAEAEDPDAIVEGCIAAHRKAISGFGGNP
NVQETMLDEAWNPIHAAISLEGEPTLYPRLGDLVEAFYGHGFKSVFIVTNGLDPEALADL
GAEPTQLYVSACAPDEETYRRTCRPLIPDGWGRLMKSLELLRSFSCPTVLRHTLVPDLNM
HDPAGYARLAKVSNATYLEPKAAMSVGYARNRFGYHEMAWHDDIRMFAEELADESGYDIL
DEQPVSSIVLLSRLPEPRKLY
>A0A523WCB9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLQESRTTLESDILETLVPPPLIQALKRQKYHLVGRHSAVKRCRWLYETLIHNRSCYKQK
FFGIKTHQCIQMTPALFYCPQQCLFCWRAQSGDMGITWNEMKLPKWDPPEEIVEGSIKAQ
LRILSGYKGNPKTNLQKLEEALKPRHAAISLTGEPTLYKPLGDLIQAFHKRRFTTFLVSN
GIMPSALARLSEEPTQLYISVCAPDKETYKQICRPQIPKAWEKLKETLKILPSFKCPTVV
RITSVRKLNMKKAEAYAKLFEKASPTYIEPKAYMHVGFSRLRLGYSNMPSHKEIREFAIQ
LAKETGYNITDESKESRVVLLSRLKKPIRFSDG
>A0A7C7UHZ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
METKVSWTSLMAERFKIEKYQLVGRHSAVKKCNWLHQSLVHGRVCYKQKFYGIQSHRCLQ
MTPSAYHCTLRCLFCWRVQPEDLGFNSPLEASKPVKKPDSPDFIVEEAIKAQRRILSGYK
AHENLDKVKYEEALNPAHAAISLTGEPTLYPRLGELLEAFHRRGMTTFLVSNATMPEVLL
NLSREPSQLYLSLHAPTEEVFQHVCRPLTGGGWTGVCRSLEALKSFNCPTVLRLTLVKEL
NMDLAEAYAKLILKAEPTYVEPKAYMWVGFSRRRGLRYEHMPTHREVKAFAEDLAKLTGY
NLISEASESRVALLSRLSQPLKVKAG
>A0A7C4ZU55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSTYPSHLYQILKKQQYHLAGSHSAVKKCSWLHKSLVSGRVCYKETFFGIKSHRCLQMSP
SLFHCNQRCLHCWRVMPEDVGLTWDELSKPKGGWDEPETIYEESIKAQRRILSGYKSLVI
KGKVSAKKFEEALNPNQVAISLTGEPTIYPYLSELIRIYKTKGFTVFLVTNGTLPKVLEN
LYPLPTQLYISLTSYDYDSFVRLNRPISTSLWGSIFDSLSLIKSLECPNVLRITSIKGMN
MERPEAFAKIITKYEPLYVETKAYMNIGYSIYRLRKENMPTHDEIKSFSSTLASLTGYKV
IGESKDSRVVLLSKKLSSPQRFN
>A0A1Z9C025|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED103|TrEMBL
MDPTLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFIEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQIFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTMMKGVNMSSNHIKEFAALDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILAFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A8B9YHC7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus grunniens|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQGFATILAEALSSLNL
PVAMINLKDYDPDDRLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGK
TYLKGMRYAVFGLGNSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVE
ADFTAWKTKFISRLQALCKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAE
DEEPFGSTNEEESDTEDHLSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKS
EASERRAMITPALREALTKQVHAPRERRLLTYILWHESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVG
EPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSLKKIDR
PLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVT
YCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFKIGREW
WTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRKNKS
KDISGC
>A0A0E3WRK6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei C16|TrEMBL
MPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>A0A2R6LMJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_5_68_122|TrEMBL
MPKQVSDPDYHSENHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKCNERC
VFCWRDHTGHAYELDGVEWDDPEAVVDASIDLQRKLLSGFGGNDDVPREAFEEAMEPRHV
AISLDGEPTLYPYLPELIEAFGDRGITTFLVSNGTRPEVLEACDPTQLYVSVDAPDRKTF
GEVVKAVEDDAWDRLVETLDVLADKDDTRTVLRTTLLSGYNIHHPEWYAAMFYRADADFV
EMKAFMHVGNSRDRLDRDVMPDHEAVVGFTEAVGEYLPTHPVLRDVEASRVALLAREEDT
WVPKLKGGSEFWEANPYAS
>A0A830FGA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula salaria|TrEMBL
MSDADDGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTQEMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWEQDPLVEY
>A0A7C5GVB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDESLRRMFEKQGYAIVGNHSAVKTCHWLKESIMRGRVCYKQSFFGIMSHRCLQMTPVAN
MCNHACRYCWRYQGSDDIQVEWDDPAAIVEGTIEAQRRLVSGFKGDERCDLRVWKEAREP
NQVAISLTGEPTMYPHLGELIGEYHSRGFTTFLVTNGTFPDVLERLDPLPTQLYVSIDAP
NESIYRRLCRPKISDGWERLMRTLELLPSLDTRTVARHTLVKGENLGFERQYAELDAIAD
PDFIEPKGYVFVGYSRERMSMDNMPSMDDIRSFAGRMSELTGYGIAGESPPSRVVLLKKD
GVTLRIDETPANET
>A0A2D6U2U8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGKFYGIASHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLGEYIDLCHKHGMTTMLVTNGTFPKVLERLDPLPTQLYVSVDAP
NKKVFNEVCKPKWNKRSWEQFEKTIDLMPSLDTRIVSRHTLMKGINMSDQHIREFAALDN
RADPDFIENKGYVFVGNSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GQEITPIPIPKATMFFPDDLGIAPSVKHLPIIQ
>A0A2E9L9N9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPIELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A2E3X0A6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPAIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSETLNKVDSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NQEIFNRICKPKFDSHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDVMSFSNALAPLVGREVLSDRRESRVALIGK
EMIPVTLPEKTRDFPADLGIAKPQNFKLPSFQN
>A0A2E6JLF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPKLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRGRQCYKGRFYGIESHGCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKTVFDDICKPKWNQGAWEKFEQTIDLMPSLDTRTVCRHTLIKGKNMSHEHIREFAELDN
RADPDYIEAKGYVHVGHSQENLAASNMPSHEDIMAFSHEIAPLTNRQVLDESRPSRVALI
GTEIIPIQVPEAEMYFPEDLGIAPPVKHLPVI
>A0A2D8CNU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKXRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQMSPVVD
QCXLACTYCWREPHMDTLELTDQDPMDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKAVFDAVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDXHIEQFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARKVLSDSRPSRVALV
GTEITPXPIPEPTMXFPDDLGIAPPVKHLPVVS
>A0A327HHN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPTLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFIEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQIFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTMMKGVNMSSNHIKEFAALDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILAFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A2E6AR48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELVDQDPLEMLYESVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEETIDLLPSLDTRVVCRHTLIKGKNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRELAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMHFPEDLGIAESIKHLKIVQ
>A0A5B9DFB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Prometheoarchaeum syntrophicum|TrEMBL
MEKKTIQSGFDKEKLVKSYMKSNYRIIGPLKHSAIKPCHWQEQKLLTGRSNRNCYKGYFG
IESETCIQNTPTLPFCNHQCVFCWRDYENASFGPEWKGPMDSPKVIAREMIRHSKNLIFE
HITKKKSIDNLDLMHKILYTYHDTIKQQNLADIVFGELDLAKILNTTRTKIHRAVLVLKN
CSILKNPTEDKYVLQNEIKNKIQSYEEIDQLIAKDVTTKEDLDKVFKNAEVPKHAAISLA
GEPMLYPAIGELVTEFRNRNMCTFIVTNGTQPEVLKKLVEKNQLPTQLYVTLTAPTKQDF
IKISRPLTKNAWENLMETLRIIPTLSCRTVIRITSVKFLNINLGMVPNYVKLLKMANPNF
IDIKGFTIEASALNLEKRLGKFKGDHTLRDFGPNFKDLLDFAQELEKIGGFPIIEKHKPS
KDILLRGSWPEGKSIKIDFSKV
>A0A5A9MY11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triplophysa tibetana|TrEMBL
MLFLATLWSLTYCAVGSEISGALNDVWGYTEPYLLAVWQNRSCVYTAAAVLLGLWFTVNV
AFRKKETINPVSAGLHSSVKKQELSPDTEKVVHVAGVRIFYGSQTGTAKGFAGELAEDVR
GQGLECEITDMKEYDPDDRLAEECSSKMICVFVVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSIQADFKAWKPKFLSRLQALANGEKKVCSGKCKSDSCKNKKKHKEEAEDSQTKKFIQEE
LMESSSDAESSAEEDKSHGSVIDMEDLGNVMNRMKKAKKMEADEENSQRIKLSKQNGVRN
SVAEEDRREMITPALRDSLTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESH
RCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQEAVENHRSMIRQFRGVPG
VRPERFDEGLTVKHCALSLVGEPIMYPEINTFLRLLHHQHISSFLVTNAQFPEEIRNLVP
VTQLYVSVDASTKDSLKKIDRPLFKDFWQRFQDSLRALGEKQQRTVYRLTLVKAWNVDEL
KAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVQQLANLLPDYEIAC
EHEHSNCLLLSHHKFKVGGEWWTWIDYERFQELIQEYEESGGTKSFSAIDYMAKTPTWAL
FGARERGFEPSDTRFQRKNKTKDISGC
>A0A0E3PU95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina siciliae C2J|TrEMBL
MPLEERKEEKKDSGESFPEIPEENRGEEQASLPFDIPDFATLLKKQSYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLICNHRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDIMK
EKCSRTVIRTTLVKGENIFSPEGYAELIKKASPDFVEIKAYMHLGFSRLRLDRSAMPAHA
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGKKSPVRKVSFKD
>V9EWZ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora parasitica P1569|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A061J8Z5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma rangeli SC58|TrEMBL
MTDIPTDLLLWALLGALLPVITMTIATLLGRWALYREKQQRQKMEQQAQADATSAMDTDA
GSTREAKGSCCCQASANGGKDEGAGKKILIAYATQSNTACTLAHKLFSTLNTVLHETGGK
EAQQGSACCGGGRYVPEIKVLQLAEEGRQCSVEHLLESHAYSFVVLIASTYTNGTAPESS
QVFADLLQDAYTDFRVPRDALAQTRFAIFGLGDVAYGAKHFNRFAKNLYAWCNGLGATFV
VPPVYASESNTVSLFNVFTASLVKWVSRVVFTADGVVVVRKPQRAKGTRPPTGDNAASRV
RAAPDSEDDEEEETDGEEKAGNESRGGGNKRNNSRSNINESGDDVEDVVTDDEDGGAAEG
EASLTSAGDPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNI
ASHQCMEMTPSLACANKCVFCWRHHTNPVSRSFRWKVDPPQQLVAGGIEGHQKMIKQMRG
VPGVTPERLEEAMRVRHCALSLVGEPIMYPEINAFVDLLHERGISSFMVTNAQFPEQLRL
LKPVTQLYLSIDAPTPEELKCIDRPLFEDYWERCLACIRELRRKPQRTVFRLTLVNQYNT
ENVAAYAHLVRLGWPDFIEVKGVTYCGTSATSTLTMKENVPRHEEVVRFCEDLCAALASD
TAPKDKQTWLGREPEPATERYMFNSNENKTSDNNKEDNTNGNTAEEGGAEAAASSGPYRI
ACEHEHSCCVLIALRRFLVQGVWHTWIDYDKFAALAGSGRTDFTAAEYAAPTPSWAVFRS
NEKGFDPTQLRVHRKSGKPVIVTSGC
>A0A7K4BH51|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MHSEACKALRKQGYQFVNTTSSAAVKPCMWNKRALRGGDMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVTEEEECPPAEIIESLPRLQKKALSGYKVSPYVTPERFAEALS
PTMVAVSLSGEPTCYSHLPELIDGLNAEGYTTFLVSNGTRPDVLDRCRPYQTYVSLDAPD
RETYLRLCRPREDYWDLVQESLAGLASRRSVIRTTVVRGYNDFAPEGYAAIYQDSGARFV
EVKGYMYLGYSRNRLQKDQMPKHRDVRAFAAEIADHCDYFIKDESPVSRVVCLERDV
>A0A8J4W1Z1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Castanea mollissima|TrEMBL
MSLSSVSARLTLLALLSASTFYCFYESRRLRKLKLSLQNPKPDRSVSKPKLFFVSQTGTS
KALAQRLFDLLAINDLAFDLVDPKDYEPEDLPKETLVLIVASTWEDGKAPASAKFFANWL
AESADDFRVGSLLLSNCNFAVFGVGSGAYGATFNSVARDFSKQMRAMGAREVLPVWEGDV
DSGDVDEVFDAWSVKVVGFLKHGGVVENGGGEVLVSESDGESVADDEDSEEEEGGDDGSE
IVDVEDIAGKVPSRKKAVAVAETNGKLNGKKDMVTPAIRASLEKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
LEIVNSAIDLHTNMIKQMKGVPGVTLERLMEGLSPRHCALSLVGEPIMYPEINTLVDELH
RRRISTFLVTNAQFPEKIEMLRPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKA
LREKQQRTVYRLTLVKGWNTEDIDAYSKLFSIGKPDFVEIKGVTYCGTSATSKLTMENVP
WHSDVKAFSEALAQRSQGEYEVACEHVHSCCVLLAKTDKFKVNGKWFTWIDYEKFHNLVA
SRKPFSSMDYMAATPSWAVYGAEEGGFDPGQSRYKKERRHKSSTD
>A0A075GMP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_160_B06|TrEMBL
MIFSMSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRNEGSCYK
HKFYGISTHSCMEFSPAGMYCENRCIYCWRPMEFYDSMEMQPQNVAEPEEIMTKLMAERK
KLIMGHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVT
NGQEPDMIQKLQDENALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDT
RTVIRLTLIRGYNDDKEMIPAFTSLLRQSNAHFVEIKSYMHIGRSINRLEYSDMLEMDEV
RSFANKLTQENNTFTVMDESEISRIVILQNKKRFIDRFIPTYC
>A0A5N5NRK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salix brachista|TrEMBL
MTIMPLTSTPARLTLLALLSATTVYCFYKSRRLKKISLNPNPNKPKLFFVSQTGTSKTLA
HRLHNLLASKNLHFDLIDPQSYEPEDLFKEELVIIIASTWEDGKAPQNANFFANWLAESA
GDFRVGSLMLSECKFAVFGVGSRAYGETFNALAKDFSRWLRDLGAKEVVGVGEGDVDAGE
LDMVFEEWSGRLARVLKGESVDNGEVCGNGVVVIDESDDDEDDGGVESDIVDLEDIAGKG
PSRRSFVEAQSNGKLNGENGKLNGHKEMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVK
SAIDLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHRRRIS
TFLVTNAQFPEKIQMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLTEKQ
QRTVYRLTLVKGWNTEDLDAYFNLFSIGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDV
KAFSEALSLKSKGEYEVACEHVHSCCVLLAKTEKFKVDGQWFTWIDYDKFHDLVVASGKP
FNSKDYMAATPSWAVYGAEEGGFDPVQSRYRKERHHKTTH
>A0A199VUQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ananas comosus|TrEMBL
MTDASLPSLPPRLALLALLSFSSAFFLFKSLRLRRLRISAPSPSNPNPKIFFASHTGTSE
TLARRLSHRLRSLGLPFDLVDPKHYEPEDLPKETLVLIVASTWEEGRPPPNAEFLARWLA
ESAEDFRVGSLLLSRCRFAVFGVGSGAYGEAFNAAARDFSQWMRSLGATEMLPVSEGDVD
GGDVDEVFDAWSEKVIGLLKEKEEEGNGKVIGLLKEKEEEGNGELLGSGVESDASDGMEE
ESEEEADVEDSNEVDMEDIAGKAPSRKSSVTLVNGKSSGTLVNGKGDGLREMVTPIIRTS
LEKQGYKIIGSHSGVKLCRWTKSQLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFC
WRHHANPVGKSWRWKMDDPLEIVDAAIDQHTKMIKQMKGVPGVKQERLDEGLSPRHCALS
LVGEPIMYPEINTLIDELHQRRISTFLVTNAQFPDRIKMLKPITQLYVSVDASTKESLKA
IDRPLFGDFWERFLDSLKALHDKEQRTVYRLTLVKGWNAEEIDAYANLLTMGKPDLVEIK
GVTYCGSSATSKLTMENVPWHSDVKAFSEALAVKSNGIYEVACEHVHSCCVLLAKVDKFK
VDGKWYTWIDYERFQELVASGTPFRTEDYTALTPSWAVYGAEEGGFDPGQSRYKKERRHG
ARS
>A0A832ZFR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus paralvinellae|TrEMBL
MHPFIPSLGEERVKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKNSRVCYKQKF
YGIHSHRCLQMTPVLAWCTHNCIFCWRPMEGYLGSELPKPWDDPAFIVEESIKAQRKLLS
GFGGIKDRINVKKFEEAQEPRHAAISLSGEPTLYPHIGNLVEEFHKRGFTTFIVTNGTVP
EAIEKMRDEDKLPTQLYVSLTAPDIETYNSVNIPMIPDGWERIIKTLELMRDLPTRTVIR
LTLVKDENMHNPEGYAELIIRAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEEL
VKHLPGYHIEDEYQPSRVVLIMRDDISKEERFIKH
>A0A833DYN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus paralvinellae|TrEMBL
MHPFIPSLGEPKVERVKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKNSRVCYK
QKFYGIHSHRCLQMTPVLAWCTHNCIFCWRPMEGYLGSELPKPWDDPAFIVEESIKAQRK
LLSGFGGIKDRINVKKFEEAQEPRHAAISLSGEPTLYPHIGNLVEEFHKRGFTTFIVTNG
TVPEAIEKMRDEDKLPTQLYVSLTAPDIETYNSVNIPMIPDGWERIIKTLELMRDLPTRT
VIRLTLVKDENMHNPEGYAELIIRAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFA
EGLLKHLPGYHIEDEYQPSRVVLIMRDDISKEERFIKH
>A0A7J4ECN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MELRATLNYHDATRGTLEKQGYHFVGAHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAH
RCVQMTPSIFCNQRCIHCWRPLEAFNIGEEAVVWDTPAEIVEGCIKEQHRLISGFKGSSK
TDKATFAEAEDPKHAAISLIGEPTLYPYLQELIQEFHSHGMTTFVVTNGTNPDLLRDIHP
SQLYLSLNAADEAIYKRVARADYWAQIQDSLEVMKRQKERTVIRITCIKGLNMVNPQGYA
ELLDIANPDFVEVKAYMHIGYSRKRLSRAAMPLHSRVKEFASEIVAQLTSSGSDYEIADE
SEISRVVLISNLSSGKKALPKI
>Q6LXB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis (strain S2 / LL)|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFEAPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLDMGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A024SI03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypocrea jecorina (strain ATCC 56765 / BCRC 32924 / NRRL 11460 / Rut C-30)|TrEMBL
MDAASRLQLEALAADLVDVWHAYRTPIILSALLLLAGLRIFLHTTEDREPLVALPKIYNE
PQQPQVSEKTISKAQPVAETEKKSSGPRRIKGGVTRKASQEDKTAPAEHDRPAKVLVFFS
SVTTKTEKIAHDYIKTLEAFLDQKANETDDKFLKPELLDLTEIDFEDYFVSPPKSPEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLVGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFTEWTFGVQEVIAQASQTGFLGEG
VPGSGDAVESDDEEAEGDDGEVVFDDEEPSNSKESDGSRPLDDVEDLGKMIRPSKDGNEG
PRKAALAVDFTTYPSASKRKGQAPVIKEMVAKDSPTYNALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEM
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALDRRLQEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQRF
FELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAVVSREAPE
>A0A7N9CA35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca fascicularis|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPK
DTRHQRKNKSKAISGC
>A0A7K4PF63|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Melospiza melodia|TrEMBL
LDVSMDMWSYFHTCLGSIWLHRLYIYSAVALGISLWIVIHFTTTRAKKKVTEPSHGSPSA
PEGTSDKLGNGCAPRQAHRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEVINME
DYDPEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLQEAANDFRVGRSFLQGLRY
AVFGLGNSAYGDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKD
KFLTRLRALCRGEKKPCRGKCKKGKCKTPGKQSKESSEREHGTSEQDDTEGEELFETGSE
EEAGDTNSVIDVEDLGNVMGHMKKAKVLLLEGAWNVHSVSHSGYPLVYFMCQFLQANLSC
LMICALFSGYKLIGSHSGVKLCRWTKVCSVSFSHFINKNKARDLLRWVPQVGSRWQWVTV
PSSLRHHTNPVGTEWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHC
ALSLVGEPIMYPHINQLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKES
LKRIDRPLFKDFWERFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASSLTMANVPWHEEVLSFVQELARLLPDYGIACEHEHSNCLLLAHCKF
QVDGEWRTWIDYGRFQELVRERERSGGARTFTAAEYTARTPPWALFGAKERGFDPLDVRF
QRKNKARDTSGC
>A0A2Z2MH95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus profundus|TrEMBL
MAITFVSNPNMPEEIANLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGMP
NINMKKFEEAWNPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWERIKETLRLMNDAQTRTVIRMTLVKGE
NMSNPEGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELLKYLPGY
HLEDEYEPSRVVLLMRDDVDPNGRGLNGRFVKF
>A5K9A9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax (strain Salvador I)|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSKLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSTHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEILSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>G3BAG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida tenuis (strain ATCC 10573 / BCRC 21748 / CBS 615 / JCM 9827 / NBRC 10315 / NRRL Y-1498 / VKM Y-70)|TrEMBL
MLSSSTLVVLALYLLVGGRVSFAAAGIFMHFAFRKGVEQEDPTLQKTVKAKSQSKSPIYA
IDFTSTTFTPDLTSQIPKPKKINRRSRQPKVFRATRPAVVKKNEPVLTSSVKLTESQIYI
FYTTLTGSSQRVAKSLCDKLSNIDLKLPPKLMSLDDDVDDLEEYFMRTPTNDYKNIYLIV
LPSYETDSPIDYFLEHLKDTYQDFRVDKYPLRNLLGFAVLGLGDSESWDGEKFCYQSKLA
DKWLAKLGGRRIFPRGEVCMKYEGESKTQEWIQNFATLLNDDEPFYLNDEVDDSDKEDVS
SDETDDTLVDVEDMGDVIRKEGIKTSMSSETKEMVAKDSPTYKSLTKQGYTIVGSHSGVK
ICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWV
LDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFQEAFQVKHCALSLVGEPIFYPYINEFV
QMLHEQHISSFLVCNAQHPDNLAKLSKVTQLYVSIDAPNRKDLRNIDRPLNSDFWERMMA
CLDILRTVQSHQRTVFRLTLVKGFNMNEVKGYADMVIRAQPSQIEVKGATFCGSSNGNGN
PLTMQNIPFYEECKRFVEELTEELQSRGYFYEIAAEHAHSCCILIAHSKFKINNKWHTHI
DYPKFFELLESGAEFTSIDYVKETPEWAVWGSDEAGFNPNDTKFDRKAEKLKKRLDREEQ
QKKVMELKAVV
>A0A2S7Y469|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Beauveria bassiana|TrEMBL
MDPLSGANGQSALFNINGLLDVWHTNRTPIILLALCGLVVLRLYIHAYEEKPDLKIIPKI
YQNTDYKNVAYKKSDNVSPPQVQEKTAVKTVGPRRIKGGVTKKPETTEESIDLNKPVKVL
VFFSSITTKTEKIGQDYIAKLEKSVAQLAAETARPILAPELLDLTEIDFDDYFIAPPKSD
DGAQFLYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLMGYSVFGFGDREGWPD
EAEGYCFQAKEVDKWMAKLTARKRAYPVGMGDMKSDHAERFSEWSSGVEEVFGQIIRTGY
LGQGVAGSGAPVESDDELEEDYDDGEVVFDDEKPSKRENGKSSSNLDDVEDLGRVIKSQG
GDANPRAPIAVDFTTYNNKSNPQNKVKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEL
IFDGVKENHYKKIKMMRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKE
RISSFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILR
EKRFRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLTMS
NVPFYWEVCEFVRALDRRLQEKGLAYGIAAEHAHSCCVLLASERFHVHGKWHTHIDYDRF
FELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVVREAPE
>A0A133VCK5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA261G05|TrEMBL
MMLSIEAKTNLEDSGYRIVGQHQHSAVKTCRWTKKSILDQGFCYKQKFYEDVHGIKSHRC
LQMTPSLPFCDHRCIFCWRNVDLNSPTWQGEADEPTEILDGAIEAQRLLLSGFKGNPNAN
KKKWEEAQNPNLCAISLDGEPTLYPKLSELIEECHHRNIVPFLVTNGQHPEHLEEISEPS
QLYISTVAPDEKTYTQICRPLVTNSWERLNESLELMPSFNCVKVLRLTLVKGWNLKDPSG
YAKLVEKAEPDYIEPKGYMFVGHSRKRLQMNNMPTHEEIAQFAEKLEKLTGYKITDESEP
SRVVLLSTE
>G7WP42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta harundinacea (strain 6Ac)|TrEMBL
MSDQLKRQGYHLVAHGAVKPCLWLRRSIRGGDQCYKHHFYGISSHRCVQMTPTLLCNHRC
LHCWRPIDEIPATSGEWIEPEELLDGILSEQRRLISGYGGAPETTDPGRLEEAKSPAHVA
ISLMGEPTLYPMIGELVEEVKRRGMTAFLVTNGTSPEAVGEVRPTQLYISLNAPDEETYR
QVSNPRDDTWGRFLESLDMMRDSPSRRVVRLTLARNLNLKDPRGYARLIEVAEPDFVEVK
AYMHLGLSRKRLGRDAMPTHDEVMGFARELSDILGYPLKNHVPLSRVALLSRGSAGEKIE
LGAGR
>A0A1V4TLT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon PtaB.Bin134|TrEMBL
MKNDLREILQKQQYRLCGDHAGVKLCHWMKQSLLKGRTCYKQDFYGIRSHRCLQMTPVVN
DCTHNCLFCWRVRGFESSVTKWQDPEVVLDTCIEGQRQLVTGFKGDPRCSPQMWEEARAP
RQVAISLAGEPTMYPYLGDFIELCHRRGMTTFLVTNGTFPKVLEGLSTLPTQLYVTVAAP
NQEIYRRLCVPRIEDGWERLMQTLDLLPSLDTRTVIRHTLVKDWNLGWEREYAALDRRAD
PTFVEPKGFVFVGDSRRRMSMDNMPSHAEVLEFGRRVGEELGYCMLKEKADSRVAVFGAE
GTDTKIPGLE
>A0A8H6NJL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum plurivorum|TrEMBL
MALFNDQLGFKAMLNNAHDAWQEIRVPVILFTAFGLFILRFYLHSTEEKSELKALPKVLG
REKKPDTKSKPVEEKKDAKPKSAPTPVPESKAVKSNGPKRIKGGLVKRPSEELKDGEPLA
RTIRPLVFFSSITANTPKIAKDYAERLENELQKTAADTGCSFTAPEVLDLAEIDFDDYFI
TPPKTEEPVDLIYLFLLPSYNIDTINDTFLEHLKETHHDFRIDTAPLSPLLGYSVFGFGD
REGWPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYQERLAEWSEGVVEVLGM
LAKTGSLGEGLPGSGAPEESDDESAAEDDDEVLIEDAEAKPEKLKSRKNIDDVEDLGRIM
KSSQPDTEVKSTSAAPIAVDFTTYGKSATQKKTPTQGPKEMVPKNSPTYASLTKQGYSIV
GSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVG
TTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYP
YINEFLGMLHTERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDF
WERFQRCLDILREKRFKHRTVFRLTLVKGFNVEDEVEGYAQLVEKGLPCFVEIKGVTYCG
TSTASNAGLSMSNVPFYWEVADFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKD
GKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKI
EA
>A0A1V4U781|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon PtaB.Bin009|TrEMBL
MIDLLTREGFSTFLVTNGTRPDVVARCRPFQTYVSLTAPDNETYRKVCRPMEDTWEAIQQ
SLSLLGSRRSAIRVTLVRGYNDFSPDAYARMIQDSGASFVEVKGYMFLGYSRKRLERGNM
PSFAHVKEFAEKIAAACDYEARDENPASRVVCLERIR
>A0A7R5KYG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pipra filicauda|TrEMBL
DDCLAEETTSRNICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKTHLKGLRYAVFG
LGNSVYVDHYNTVGRRMDRWLWMLGASRVMTRAEGDCNVAQSRHGSVEGDFEAWKAKLLT
RLQALCRGEKKPCSGKCKKGKCKSPGKQSRESSDHERGASEHENTEAEELFETSSEEEAD
AEEAGGTNSIIDVEDLGNIMGHMKKAKREHELQEGDVGRRENPGKKDEEEEEKREMITPA
LRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPELILQEAIENHQNMIKQFRGVSGVKAARFEEALTVKH
CALSLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTRE
SLRRIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLGKPDF
IEVKVSCLELFPFFHRFFSSF
>A0A084RRM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stachybotrys chartarum IBT 40288|TrEMBL
MDTLWPNHPQADGQVNGVLAIWHTYRTQIILLALVILFGARVILHTKEQRQDLIVLPRVY
EKEVLIPRSSESENAKVNSTKEAKTSGPRRIKGGLVKRPSDDDNAKQTEQRIKTLIFFSS
ITTKTEKFAHAYLESLQSDLKQLAEKTGKVFLEPEVRDLTDIDFDDYFVSPPKLGDDVAL
LYLFLIPSYNIDTINDTFLQHLEETHHDFRIDTGSLASLLGYSVFGYGDKEGWPDEAEGF
CFQAKEIDRWMAKLTGRKRAYPVGMGDMKSDHTERFNEWASGVLEIMEHTARTGNLGEGL
PGSGDAEESDIEDEGDIDDGEVLVEEDTLGDNEKIQSRTLEDVEDLGRTIHPSNGGKRSN
GPVAVDFTTYSAAEKKKAQTNVVKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFE
GVKDNHYKKIKMMRGMPGVRAERYNEAMKIRHCALSLVGEPIFYPYINEFLGMLHAERIS
SFLVCNAQHPEQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREKR
FRHRTVYRLTLVKGFNVDDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSTNAGLTMTNVP
FYWEVCDFVRALEKRLQDKGLNYGIAAEHAHSCCILLASERFNVDGKWHTHIDYQKFFEL
LEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDDRVDRKGRKIEPVVIRDRPQVS
>A0A8B8VDQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Balaenoptera musculus|TrEMBL
MLRGISGSFPVSTPDNPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNK
NSQEKTVPKASRDLMTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAKAVSSLDLP
VAVINLKEYDPDDHLVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEDAANDFRFGKT
YLKGVRYAVFGLGNSAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEA
DFTAWKARFISRLQALCKGERKPCGGNCKKGKCESNQRGSEAVEPGSHAQEGSHQRGAEE
EPFGSTSEEESGTEDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSAVKNEA
SERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNMMKQFRGVPGVREE
RFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRNLKPVTQL
YVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYA
RLVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVNLIADYEIACEHEH
SNCLLIAHKKFKIGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGAN
ERGFDPKDTRYQRKNKSKDISGC
>A0A835QX83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vanilla planifolia|TrEMBL
MTFPSTTGFQARLALVALLSLSAFCIWKSHSLRRRRRRLSFPPIPNHERPAKVFFLSQTG
TSESLAQRLAARLSADGVAADLVDPRHYEPEDLPKETLVFFVVSTWEDGKPPPNAAFLAR
WLEESAADFRVGALLLSLCRFAVFGVGSRAYGSTFNAAARSLARWMKALGAVEMMPLWEG
NIDEGEVGKEFGRWSDCVVSLMKGERSLTNGAMGEEIDELEEDQQFDEDEGVGQAAEEDI
IDLEDIAGKAPSKNSKGEPMKENGRIKEMVTPIVRKNLEKQGYKIIGSHSGVKICRWTKS
QLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKDWRWKMDDPLVIV
EAAIDQHTQMIKQMKGVPGVKEEILLEGLSPRHCALSLVGEPIMYPEINSLVEELHGRHI
STFLVTNAQFPDRIKMLKPVTQLYVSVDAATKESLKAVDRPLFGDFWERFIDSLRALRDK
RQRTVYRLTLVKGWNAEDVDAYANLLSLGEPDLIEIKGVTYCGSTATSKLTMENVPWHSD
VKAFSEALAIRSNGAYEVACEHAHSCCVLLAKVNTFKINGHWHTWIDYDRFHELVASGKP
FGTIDYMAPTPSWAVYGAEEGGFDPRQSRFRKERRHGDAAMKDKLATSNLG
>A0A5J9WA07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eragrostis curvula|TrEMBL
MPPFPTATTASATSHLALLLVLSSSSIFFLYKSLRLRRERSSAPARAPTATPTLLYASAT
GTSKALASRLSARLTAEAGVPVRATDAAAFEPDDLPSVPLLLLVLPTHDAGAPPPAAAFL
ARWLEESAADFRAGALLLSGLRFAIFGVGSRAYGETFNAAAKSFSRWLRALGAVEVVPLG
EGDVDGGDIEVVFEEWSGRVLRVVKGEEVSDAVNGESDGLDVLEGEESDDDDDEDVVDGE
VDMEDLAGKAPGRKQNGKVENGLRNGEENGARDMVTPIIRTSLEKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDD
PLEIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINTLVDEL
HRRHISTFLVTNAQFPEKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLK
SLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLTMENV
PWHSDVKEFSEVLASKSGDVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELV
TSGKPFKSQDYMAMTPSWAVYGAEEGGFDPDQSRFKKERRHGAAALKR
>E1RI02|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)|TrEMBL
MQSEACKALRKQGYLFFSKESSAALKPCMWNKRALRGGDMCYKNKFYGISSHRCVQMTPT
LKCNQNCLFCWRSMEHEVVETAECPPELIVEKIPALQKKALAGYNPSADTSTTDPALWEE
ALSPNMIAISLSGEPTLYSRLPELIDMLNGAGNTTFLVSNGTRPEMIGRCHPYQTYVSLD
APDRETYLKVCRPEEDYWDNIQKSLSLLGERRSAIRTTIVKGLNDFSPENYAAMYENSGA
SFIEVKGYMYLGYSRFRLERENMPEHSEVRDFALQISKYCNYKITDESPISRVVCMERR
>A0A662W3I7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobales archaeon|TrEMBL
MQTKTLKTPKTLKDLKGYQIVGNHSAVKTCLWLKKSLKDEGFCYKQKFYGISSHRCLQMT
PALKCNLGCIHCWRPLDLLPEIKEWDEPKFIVEESIKAQRRLLSGFFGTKGVNMEKLREA
QEPNQVAISLIGEPTLYPRIDELVEEFNKRGMTTFLVTNGTNPRAVEIADPYQLYISLTA
YDEESHKSLNRPKGNLWDKINESLKIISEKDGRTVLRLTLIKGLNMKPEKFAPLIEKASP
KFVEAKAYMHLGHSRFRLERDAMPSHEEIRKFAESLEKISDYRISDESPISRVVLLERG
>A0A0H5CAG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 / NRRL Y-1542)|TrEMBL
MPSAILVPLAVAIYYAAGGRLSIALAIGVIGYIVIYESKKLKGTTGQKTVVGSEDEHNHE
HTHTHKHKHKEGGCGKLCTCKNKGLKPKKTLSALKNKKGFGQKKATNGSEKDMAVDFTST
FARPTKVSSADREEPAKKKRVPKIIKSKGAARGIPKTTWTKAPTSLLDSNIIIFYSSLTG
ASQRSSQYLYDNLCAIGDLKNKPQLLNLDEVADLDDYFIKTPDLENLVYCLVLPSYDVDS
PIDYFLETLEDTYQDFRIDKYPLKKLMGFTVLGLGDSESWPEKFCYQAKKTDYWLGKLGG
RRIFPVGEICMKTGGDLKVHEWISLFTDALKDDEPILYEYIDSDNEEDSDNSEASEKSQD
TLVDVEDMGKMMSSSKEPETTSETKQMVAKNSPTYKSLTKQGYTVVGSHSGVKICRWTKS
ALRGRGSCYKFAFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWQVDEPDVIL
EGALAGHYAKIKQMRGVPGVVAERFAEAFRVRHCALSLVGEPIFYPHINEFLSMLHEKEI
SSFLVCNAQHPDQLEKLTQVTQLYVSIDASTKSELKKVDRPLFRDYWERLMRCLDILRTT
QSHQRTVFRLTLVKGFNMGDVSGYADFVEKAAPALIEIKGATFCGSSAGNGNPLTMQNIP
FYEECQKFVVSLNEELNRRGLGYGIAAEHAHSCCILMASNQFKIDGEWHTHIDYPRYFEL
LRSGKPFDKLDYISKTPDWALWGSESAGFNPEDTRVRKKGKYKKLTT
>A0A7C4Y0J7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MPLFSPELLRKSGERKMLLQSTALTIADLLRQQKYQLIGSRKTAAVKKCHWLHIALTSNR
FCYKNWYGIESHRCIQMTPTLACPNSCLHCWRVEKGDPEVPSWREEDFMTHDDEKTIFEQ
AIKAQFRILSGYKSNPKVIKERYIEALHPKHFAISLAGEPTLYERLGGFIELCRSKGFTT
FLVTNGMYPERLAKLLDGGQPSQLYVSVNGSSEEKFVALSRCSLADGWRRLMKSLELMKE
LGCPTVIRITLIKGVNDYEGDVEGFAKLTSLAEPWYVEVKSYMYLGYSRFRLGLKNMPKH
RDVLEFAKKLSKASGYNLVADSLESRVALLSRIGEPVKVRP
>A0A662H8T5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MITLSEKQISVLRRKHYGVVGRHSAVQICRWTKKSILGEGTCYKERFYGVHAHRCAQFSP
VALWCNMNCIYCWRPMEWMKNYNIGYEDVEDPETIIRGVIEERRKLLIGFLGNPKASRSR
VMEALEPDHYAISLSGEPTMYPRLDEMIKLLRDKYMARTIFLVTNGQVPEMLMKLEERKA
LPTQLYISVTAPNKELGIRIHKPVFRDFWERLLSSLRHMGELGGKTRRVIRLTLIKGYNM
DESYMPEFTKLIRLANPDFVEVKAYMHLGLSTLRLARTNMPSHKEVRCYSERLVNNYLNE
FKVEDEQVESRIVLLKNTSSKVPTKIYSDD
>A0A662IWM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MYLPPHVRSLLTKQRYHLVGERGHAAVKKCHWLHKALVGGSPCHKSWYGVQSHRCVQFTP
MLSCPNACLHCWRLERGDVEGWDELSIGELDDPEVLIQGALREQLRIVSGYKSNPKVDRM
RLEEARHPKHFAISLAGEPTLYPMIGALIGLLKSKGFTSFLVTNGLYPKTLSSLPYEPSQ
LYVSINAPSEELYRRVCRPSLKDSWMRLMDTLDLVRSFKCPTVLRITLIKGVNDVDLEGY
AKLVERAQPYYVEVKAYMYLGFSRRRLSLENMPRHSEVLGFARSLSQLTGYEFIADSLHS
RVALLSRIGRPIRVSP
>A0A093L224|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fulmarus glacialis|TrEMBL
IDVSMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKKSNGNLTSSEGI
EDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDYDP
DDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLS
QLQVLCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEREASEYENTEAEELFETSSEEEAD
AEEAGGTNSVIDVEDLGNIMSHMKKAKREHELEEGDVGMSLTRENAGRKEESEKREMITP
ALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAK
HCALSLVGEPIMYPDINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTK
ESLKRIDRPLFKDFWQRFLDSLKALSEK
>A0A5N6U2F4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus avenaceus|TrEMBL
MDGDSLMEGLLAFWHSYRLPILVAIATTAIVLRIYRLSQTKSKAPTASSIPSSPRSRSPE
KSEKSEISEKHQEASQKPAQNETAPKPASGPKRVSGKKPLKVAGRRNGSDQGPPVSFIQP
IVFFASLTGNTERYAQILAEDLRTAARERADPENRERGLLPPQVHDLSYIDFDDYFTTAP
KPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLASLAGYSVFGFGD
REGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKTDAESALKEWSHGLKDILYD
ILDNGGLGEGIPGSGDPLESDEEDLDDEGADDQSDKRPKRKKNQTVVDLEDIKMSADGQG
SAPVPVDFTTGGAPAASSQSTQKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLIFNG
VKDGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLEMLHNEQISS
FLVCNAQHPDQLETLKRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
IQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQEFVLSLNKELERRGLDYGIAAEHAHSCCVLLASKRFYVNSKWHSRINYDRFFELL
EKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVYKKGKKKGLEAPAA
>A0A2V2MVQ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum lacunae|TrEMBL
MRSARCKIPNGHSPEISLRRMGYLFFDPSSSASLKPCLWCKRALTGGEMCYKHQFYGISS
HRCVQLTPTLKCNHRCLFCWRSFEHEHPGEKDLPPADIVKRIPFLQKKGLAGYKISPKVT
PQRWDEAINPDQVAISLSGEPTLYPHLPELIEMLNQKGCTTFLVSNGTNPEELKACRPFQ
KYVSLTATDRETYLKVAQPLEDYWDRLQESLVSLGKDGDQGARTAIRITLVKGINDHDPE
GYARLIQESGASFVEVKSYMHVGFSQRRLTIKHMPLHPEIQAFVETILPHCDYTIKGENS
QSRVICLEKIENA
>A0A177FFR0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fonsecaea monophora|TrEMBL
MDLGEAGAAPVILADWLDRLLNYWHENRAVVSTLVGLCVLAVVVQRRHASKSAQHGSPTL
EKAAWLAPKDDAHVQTGKDQRLQSPSRITPSLTSGQARKPRTPAAAARVVTGRKPASSRG
QAALQRRREPSRMQPLIFFSSLTGTTERLAKQVAADLEGVSTAYPAILRPQVYDLSYVDL
DDYFISGPKTPVPSADVSYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLAG
YTIFGIGDKEGWPTEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSNVDKSLKDWVG
GVCNVLKEVSTSGALGEGVPGSGEPVESGDEEEPEDGDEETDEFPDSGRNKRRKLANTTD
LEDVGGKANSYTSPIAVDFTTYSSRPSPATTLKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPKLIFDGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNS
CLDILREKRFVQRTVFRLTLVKGFNIEDEVEGYAHLVAKGLPCFIEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALDKALAKRGLEYGIAAEHAHSCCVLIASKRFLIRDKWHTL
IDYDRFFDLLQSSTDFTPEDYCKATPEWALWGNGGFDPRDERVDRKGRPKEKKISGGDDD
GTVSEARNGIKVGEQKADLDF
>A0A0E3RVT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei LYC|TrEMBL
MPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>A0A6A4LQ14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhododendron williamsianum|TrEMBL
MTTMPSPSATAHLTLLALLSATTFYCFYKSRRLKNLPKNPIPNSPPTGKLFYLSQTGTSK
TLAHRLLDLLTSNDLPFDLVDPHNYEPEDLHKETLVLIVASTWEXGKPPPNGKFFADWLA
ESAEDFRPKSTLSKCRFAVFGVGSLSYGENFNAVGKEFSKQMRALGAEEVLPLWEGDVDG
DDLDEVFGAWSEKLVRVLNGGGLGNEAFGIGYGAKDESEYEMISDSDEEDGGENGGESGV
VDLEDIAGKAPSRKSTTIVKSNGKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVKLCRWT
KAQLRGRGGCYKHSFYGIESHRFMATFLLVERRSCHPQCQLWLLLSENLTLSLSQLIRCM
ETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLVIVNSAIELHTKMIRQMKGVPGRPY
VSELGIFRTGVKPERLMEGLSPRHCALSLVGEPIMYPEINSLVDELHRRRISTFLVTNAQ
FPEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFLDSLKALKEKHQRTVYRLT
LVKGWNTEDLEAYSSLFGIGNPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALA
QKSKGEYEVACEHVHSCCVLLANANKFKIDGEWFTWIDYEKFHNLVASGRPFDSKDYMAA
TPSWAVYGAEEGGFDPGQARYKKERHHKSSH
>A0A2S4L8N8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tolypocladium paradoxum|TrEMBL
MELSRWLSSLGPGTAVAEPNDAADLVELWHGHRTPLILCAFAILVSIRVYLHRYEGKEEM
IALPKIYKENEPPTTSAQTARGPLDEKTAPKSNGPRRIKGGIARKPPRGEKEDVDLTRPV
KALVFFSSVTTKTETFARDYLTMLDKATEHLAQETKREFLKPELHDLSEIDFEDFFVTPP
KSTENVVFFYLFLLPSYNIDTINDTLLQHMEETHHDFRVDTASLAPLLGYSVFGFGDREG
WPNEAEGFCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFEEWAAGVHETIGHAAT
TGSLGEGVLGSGDAIESDQEDIADEDDGEVVFGDDEKDESETPRALDDLEDLGKMIRTSA
KDGNAGNQKAPLAVDFTTYGSSTKKKAQPQAPVVKEMVAKNSPTYAALTKQGYAIVGSHS
GVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPEMIFEGVKEGHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPHINE
FLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTSTS
SNAGLSMSNVPFYWEVCDFVKALEGRLHAKGLKYGIAAEHAHSCCILLASERFKVDGKWH
THIDYQRFFELLEERGPDGDWRPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIENVV
VREQPPGEVW
>A0A151EHY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theionarchaea archaeon (strain DG-70-1)|TrEMBL
MHPELKTLLKRQRYRIVGNHSAVKLCHWLRRSLLEDRFCYKQKFYGIKSHRCLQMTPSVT
ACTQKCLFCWRPTQFTETQLREYDPPDFIAEESLKAQKVLLTGYFGLPDRVSADKLKEAL
TPTNVAISLAGEPTLYPELSDLITEYKKRGMTTFLVTNGTSPEVLETLELPWNLYLTLAA
PTKSIYKKLCHPQTNGWEKILKSVHLFSALPTQRVIRLTLVKEFNLTNPQEYARLIEKAA
PNFVEAKAYMYVGYSRYRMTIDNMPSFEDIMDFARAIEVNSSYTISDFQKASRVVLLKRE
>A0A8C6LLZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
MKNYDPDDRLADEVSEVPQRTELLFNQRDTGERLAAGLSPTEPGRAQPAEETWVPLPMGS
PLVGGAKGVRCSCLFLKVCPVFVFLLLPSAAIFNMISSQCVGRSVCVFLVATYTDGRPTE
NAEWFCKWLEEASTDFRYGKSYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKR
ILTRGEGDCNVVKSRHGNVQADFQAWKVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNE
EVTSQDASAEVTCPFSACFREGGRGTSYICSDLCNSCDLVGFMGLVFLLEHKWLFLMNGG
KKTEDDGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGV
PGVKAERYEEGLEVKHCALSLVGEPIMYPEINTFIRLLHRHRISSFLVTNAQFPEEIRNL
EPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVE
EMMAYAELITLGQPDFIEVKGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPRYEI
ACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSW
ALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A365N885|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella intermedia|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTREEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFSRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A485NM65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lynx pardinus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSILVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKFKIDGEWWTWIDYNR
FQELVQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A3N9UU85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MDGIEVRKTLTKQGYHLVGSGAVKPCLWLNRSMRGGDQCYKHHFYGISSHRCVQMTPTLA
CNQLCLHCWRPIDDPVPGLKPAEPTEHLDGILKEQQRILSGYKGAGTTDQGRLKEAREPK
HVAISLMGEPTLYPYLQELVDLISKRGMTSFVVSNGTNPDVLARLKPTQLYLSLNAPDEE
TYRRISQPQGDFWPRVCESLAVLRDHSCRSVVRMTIARGLNMGPPEEFARLLETAEPDFV
EVKAYMHLGRSRARLSRDAMPEHAEVLDYAKRLGEEMGYDFSTDVPLSRVALLSSGRIPR
SLGL
>A0A1J4UT33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG1_02_60_51|TrEMBL
MDFYERYLQSLPRLRKAGYAFVGNRKHSAVKVCLWARRALCGKGSCYKQKFYGIKSHRCL
QMTPAMPSCNQRCLFCWRDTSLFSEAWPLDGADEPSEIIDGAVAAQRLLLIGFKGNASAD
RQKWLEAQEPNQAAISLDGEPTMYPKLAELIREFHRRGFTTFLVTNGTRPEALRHLAAED
ALPTQLYVSLCAPDEETYEKTNLPVGDDNWTKLNETLMLLPSLATRKVLRLTLVKGLNFH
SPERYAKLVKVSGVDYVECKSYMNVGFSTQRLTQAHMPSHDEIRAFAAELAGNAGYEFTD
EQVESRVVLLSRDAEAARNRFITRV
>A0A6G1JC87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lentithecium fluviatile CBS 122367|TrEMBL
MDILERLPSELLLIWHAYRIPLLLSAVSLATLVHLTIYLRSRRRKVSTSPAPSSPIEKKA
VELKPEWLPENTTLVPTDLNLDNHAEETVVPVAPISKVKRAPKKVRGRKIAKKAPDTLAS
FDHRTDRIQPLVFFQSLAGTTERYAAQCAKVLTEWAIGCDQAASYLAPRVHDLSYIEYDD
FFINPPKAEPNVKYFYLIIVPSYNIDTVLDNFLQNLQETHNDFRIDTAPLSGLLGYSVFG
FGDKEGWPTEEEGFCSQAREVDKWIARLTGRKRAYPLGMGDVKSDVEMRLEEWRVGVQEA
LVEIAAGRGLGEGVPGSGDPAESDEEDLDIAEDSDSVTSNPKLTKSKKPIRVDDVEDLGS
LVDPASTPIPIDFTNYVSKPTPKLTPAPKEMVPITSPTHAALTKQGYTIIGSHSGVKICR
WTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDPP
DMIFDGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLSRMH
QNRISTFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDI
LRTRRFEQRTVFRLTLVKGFNIDDEVKGYADLIARALPGFVEVKGVTYCGTPAAGSAGLT
MQNVPFYEEVSAFVSALDDELAARDLPYGIAAEHAHSCCVLLADRTRFMRDGKWVTRIDF
ERFYDLWEGKVQGTRRDEAGDVVGWRPEDYVGEATPEWALWGNGGFDPRDQRVFRKGKGP
KSDAVAGGVETGTEKGGAAALEF
>A0A832U1R7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum sp|TrEMBL
MEKVWSTLKRQKYRIVGEHSAVKICHWTKKSLTEGRVCYKQRFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDTPSKYDDPETIIEGCIEAQRELLSGYHGFLETVDINKLKEAED
PTNVAISLAGEPTLYPDLSGLIDGFKKRNFSTFLVTNGTTPEVLASMDTYPDNLYITLPA
PTKETYERVCNPQIKNGWEKLNESLELLPKIKTKRRILRLTLVKDFNMADIGDYSKLIEK
ANPDFIEAKAYMFVGYSRKRLEVENMPMFDDILEFSKELEEKSGYRAIDSAPESRVVLLS
KD
>A0A2J6KS58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lactuca sativa|TrEMBL
MSSTAATASISTTSLTTHLTILAFLSATTVYCFYKSSRLRHLKLSSPSTNPNLSSATRKG
KLFFISQTGTSRTLAQRLFNLLTSNNLPFELVDPNVYEPEDLHQENLVLIIASTWEDGNP
PSNGVFLSNWLSESAEDFRVGSLLLSKCKFAVFGVGSRAYGDNFNAVGRGLSTKMRSLGA
SEILPLCEGDVDEGELDKAFGIWSKEVIKVLKAGELRGNGNDLIEENGYEMIDGSDYEDD
DDDYEDEDEENGMESDIVDLEDIAGKAPSKKDMGAITSNGKKNGQKEMVTPVIRASLKKQ
GYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWQWKMDDPLMIVNSALEEHKKMIKQMKGVPGVTAERLSEGLLPRHCALSLVGE
PIMYPEINSLVDELHKRRISTFLVTNAQFPEKIVSLKPITQLYVSVDAATKDSMKAIDRP
LFGDFWERFGDSLKALKDKQQRTVYRLTLVKGWNTEDVDAYSSLFGIGNPDFVEIKGVTY
CGTSATSKLTMENVPWHADVKAFSEALAEKSNGDYEIACEHVHSCCVLLAKVDKFKINGQ
WHTWIDYDKFHDLVASGEPFGSNDYMAPTPSWTVYGANEGGFDPDQLRYKKERNHKSTR
>A0A075HHK5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_61_H06|TrEMBL
MIFSMSCSGEVVEKEPELIQIRPSIVNQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYK
HKFYGISTHSCMEFSPAGMYCENRCIYCWRPMEFYDSMEMKPQNVAEPEDIMTKLMAERK
KLIMGHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIRYLKSLEATKSIFLVT
NGQEPDMIQKLQDENALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDT
RTVLRITLIRGYNDDKEMIPAFTSLLQQSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEI
RSFANKLAQENSAFTVMDESDISRIVILQNKKRFVDRFIPAYC
>A0A8J7ZJ49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorubellus sp. JP-L1|TrEMBL
MSDSEESGGPMQVSDPDYHSVNHTAAQTCGWTKNALEGEGKCYKYAFYGIESHRCMQMTP
VVKCNERCVFCWRDHAGHAYELGDVEWDDPAAVADATIELQRKLLSGYGGNENVPRDVFE
QAMEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTKPEMLERCDPTQLYVSV
DAPERATFDSTVKAVDDDAWERLVDTMDVLAAKDETRTVLRTTLVNGENMHSPDWYAAFY
RRAKPDFVELKAYMHVGHSRGRLEREAMPDHEDVLAFSEDVMAHMPEHDHLADVPQSRVA
LLAEDSDTWVPKLEKGSEFWTDDPLAGV
>Q8PX76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)|TrEMBL
MLYLQFSKIIFRSLYIPQRINIRKMPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDI
PDFATLLKKQGYALAGRHSAVKTCLWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCN
QRCLFCWRPTEVPVPAPGEWDFPEKIVEESIACQRKLITGFGGSPNALRERWLEGNQPNN
VAISLSGEPTFYPYLPELIEEYEKRGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLET
YLRICQPKSPALWDRINESLDIMKDKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFV
EIKAYMHLGFSRLRLERSAMPSHEEVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKS
PVKKK
>A0A2E9U406|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MILQYVKMKVINAEQELKNKQRYSEGYRLVGNHSAVKVCGYCRKALVGKDVCYKNTFYGI
ESWRCVQMSPTFFCDHRCVFCWRDIEYVWPKWQGPIDNPKDIVDGCIKAHVELLQGFKGN
PDVVAERLKGMGKPLHFAISLTGEPTMYPKLPEMIDYIKEKGMTAFLVTNGTVPEMVEQL
VKHQPTQLYISVYGSNKEMYQRTANPITKDAWERLQKSLSMINKFKRNVVRLTLVRDYNF
MDPEGYAKLIEEYKPMFVEAKGYSFVGHSQKRLEANNMPYHHEIIEFAKKIEENSSYKVI
DSKKESKVVLLAREDFKDRKMDFEGL
>A0A443SB01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptotrombidium deliense|TrEMBL
MLRKAFAAISNLINNDYNKADDLASNRYDLTVVYCTQTGNAKKIAEQFVDNLETTEVSNI
RLLNVKELDAEDYFSTISQSDIKSNLLIITSTYVDGDCPEDAKWFCKWLKEAADDFRVDK
EFLRNLNFAIFGLGNSEYKDNYCLIAKNLEKWLLKLGATKISETGFADECMASSLSDQFN
GWKSKIVLYVSTGTIDSSVIQTNNEIEDEGSSSDEENNEDIVDIEDILSEKRNNEKSIAN
GNKQMITPKLREELTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHTFYGIESHRCMEA
TPSLACANKCVFCWRHHTNPVGTEWKWEMDSPEMIVEEAIKNHCKMINEFKGVPGVILDR
FNEGLQIKHCALSLVGEPIMYPEINKIIRYLHDKSISTFLVTNAQFPDAIRNLVPVTQLY
VSVDASSKESLKKIDRPLFKDFWQRFLDSLKALSDKRQRTVYRLTLVKSWNNEEIEGYSK
LISIGKPDFVEVKGVTYCGTGKSSNLTMQNVPWHHEVLSFVKKLTEHIQNEYEIASEHEH
SNCVLIANKRFKVNGKWRTWIDYDKFHELVRKYYNSNGLEKFEAVDYMCETPNWAVLGSD
ERGFDPSENRFRRKTKN
>A0A2D6ND03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MLIKDKKKIEKKNLQLSEKYTQRLEKQAYRIAGSHSAVKVCSWTKNMIRGLGGCYKLKFY
GIMSHQCMQMTTSMSCANRCVFCWRGYKAPVSKEWEWKVDEPNIILEESEEEHHKLLVGF
KGNKEADKKTFKASNNVKHVALSLTGEPIIYPKINELIRLFHKKNISTFLVTNAQYPEQI
KDLDKITQLYLSLDAPTKELLKKIDSPLFEDYWERLNKSLEYFAERKDRTCIRLTIIKGL
NDNHLKEYASLINKGNPDFIEIKAYMFVGESRNRLKKENMPLHEEIVLFSKELVKHLSNY
RTVSEHIPSRVVMLAKNEFKINNSWQTWINFKKFHELTSKEKDFSTKDYLLSTPQTGLSG
KGTRDLIREREEIELE
>A0A0F9Y5K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma harzianum|TrEMBL
MDAGSRLQLEATIADLVEVWHIHRTTIILASLFLLAGLRIFLHTTEKREPLAALPKIYNQ
EQPKTSEKPIVKAQPVVDTEKKSTGPRRIKGGLTRKSSQEGKTVTTESTDRPAKVLVFFS
SVTTKTEKIARDYINALETFVDQKAKETDGKFLKPELLNLTEIDFEDYFVSPPKSAEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHAERFAEWTSGVQDVIAQAAQTGFLGEG
VPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDVEDLGKMIRTKDGNEGT
RKAPLAVDFTTYTSANKKKAQAPIIKEMVAKDSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVIDPPDMI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLAEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQKFF
ELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>A0A7D5YU95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium brunneum|TrEMBL
MSAVCEKTDPLQGVFGGLPGAKFDDIVELWHGHRTPIIICALVVLVVIRIYIHKLEEAEP
LRALPKQFEKRIEPLSANKLPSAVNSEKPVAKPNGPRRIKGGITKKPATEETKEYDKSRP
IKMMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFFVSP
AKTVEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFGDKE
GWPDEADGYCFQAKELDRWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVQEVIAHVA
SSGTLGEGAPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRMLRT
SDGKGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSIVGS
HSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHI
NEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTS
TSSNAGLSMSNVPFYWEVCEFVKALEGRLKAKGLKYGIAAEHAHSCCILLASERFLVNGK
WHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIEN
IVVREAPPPDSW
>A0A832SZW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus jannaschii|TrEMBL
MIPEEIYKILRKQRYQIDGHTAVKLCGWVRKKMLEDKNCYKSKFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPRDIGIDISQIKEPKWEEPEVVYEKILAMHKRIIMGYAGVLDRVGEK
KFKEALEPKHVAISLSGEPTLYPYLDELIKIFHKNGFTTFVVSNGILTDVIEKIEPTQLY
ISLDAYDLDSYRRICGGKKEYWESILNTLDILKEKKRTCIRTTLIRGYNDDILKFVELYE
RADVHFIELKSYMHVGYSQKRLKKEDMLQHDEILKLAKMLDENSSYKLIDDSEDSRVALL
QNENRKINPKL
>M2TDC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O)|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLPILLSALVVATIARLIIYSRDRREKLPTSPVPQSPIE
KQKVELKPEWLPEYTTTLSSPDLNVDNHAEDDTGAVVAATKSKKGPKMVKGRKIPKKSVA
PALDFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTGCDQASSFLEPQTHDLSYI
EHDDYFVTPPKTNANVKYFYIILMPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKNDAEKRLEEWRVG
VQDALVELAEGRGLGEGVPGSGDPAESEEEDVDDAEDGNGQSSRVDDVEDLGSMVNSSSS
PIPIDFTTYKKSAPKPKSAPAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINQLLEIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELNSRGLQYGIGAEHAHSCCVLLADRTRFMRDGRWATRIDFERFFDL
NEGKVQGTRMEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKAEVEKS
EGQEVQTKKAALEF
>A0A842PH74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MEPKATLSYDEGEETKRTLERQGYHFVGTQKHSAVKTCLWLWKSIRGEGNCYKGKFYGIS
AHRCVQMTPSIFCNQRCVHCWRPLEAFNINIDTGTETELKKQSIGWDSPEEIVEGCIKEQ
KRLISGFKGSPKTNKDAFAEAEVPKHAAISLIGEPTLYPYLKELIQEFHSQGMTTFVVTN
GTNPEVLREISPSQLYLSLNAPDEAIYKKVAHADYWSRINESLDELRRKKGRTRTVIRIT
CIEGLNMVNPDGYAELLKRANTDFVEVKAYMHIGYSRKRLSRNAMPAHSRVKEFAGEIAE
RLASSDSEYKIVDESEISRVVLISNLSSGKKALPTTFY
>A0A6V7TAX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vinckei|TrEMBL
MVTKREDELVSLPNEGGNANIYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIVFFND
ILNHFNTISTITKGDKTNGTIFDGSISNEINNIEDYMLEYFQSKLLKTNQKNKDRKFGKN
WKNEKENITNNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCSIENNISEIHFD
FVNGNEFDSYTFFENSENNDLNILFMFISTYNFGSFPANCYKLEDTLTDLVNDFRVEKNY
LKNIFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLKLCSTMDNEEEFVYWK
SSLLKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSDDPKSMPINNDE
NKQTNKPVNNNNINKCDCISNGIPSEHLNTSKELGNDHNKLNNKTNGHISFSTSKMDASN
TEKCGCTSNNCFNGNDKYINEKKIINNNFETSIVNGCCKNEYEQDDELVNSDFSNESISE
NNDEINCNSSEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQIRGR
GGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVK
KHKNMIKELKGVHNVISERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLV
TNAQFPNELKKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKEKKERTV
FRFTLVKEYNMMSDEISSYAKLIEYGHPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQ
FAFHLVNSKRSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNF
TAIDYCAETPEWAVVGAPECGFNPSDQRVYTKGKNKKKNNMNTMEVKT
>A0A7L1R0M7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cisticola juncidis|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVTFGISLWIVIQLTTTRTKRKGEKSHGNPSSP
KGTADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKGFAKTLAEAVTSLNLPVEVINMGD
YDPEDGLAEETSSRNICVFLVATYTEGQPPESAALFCKWLEEAANDFRVGKSFLQGLRFA
VFGLGNSAYVDHYNTVGRRMDRWLWMLGASRMMTRAEGDCNVTQSKHGSIEADFEAWKAK
FLTRLQALCKGEKKPCSGKCKKGKCKSSGTQSKESSDHEHHGTSEHENTEAEELFETSSE
EEAGGTDSVIDVEDLGNIMGHMKKAKVVLLEGVWNEGGGMQHLFSFHPQILILVYFVCQF
LQDKLNCLMICALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATP
SLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLE
EALAVKHCALSLVGEPIMYPHINRFIRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVS
VDASTKESLKRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLI
SLGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVVTFVQELARLLPDYGIACEHEHSNC
LLLAHSKVSLPSH
>A0A6J3BAK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vicugna pacos|TrEMBL
MDPSLNTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQDKKSQEKTVPKASQD
LMTTNCLSPPKKEIIVSGVKIFYGSQTGTAKKFATILAEAVTSLELPVAITDLKEYDPDD
HLVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEEASSDFRFGKTYLKGMKYAVFGLG
NSAYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVVKSKHGSIEADFRAWKAKFISRL
QALRKGEKKSCGGNCKKGKCESNQRGSEGTEPGPHPPDRVHQRDAEEEEPVGSTSEEESG
SEDHQSLNSVIDVEDLGKIMDHVKKEKREKEQQEGETSAFRSTAKSEASERRAMISPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVELIPDYEIACEHEHSNCLLIAHKKRR
KQRLGEVRQHAPGSTAGKRRS
>A0A524CUH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPDELRERLKKQGYHLIGERGAYKACQWQKKALVKGDFCYKQRFYGIQSHRCLQMTPVVD
KCTQNCEFCWRITPSDVEVSWDQVHVSRIGTLPPDQLLDGVLMANLRTLGGYNPEIDPNV
SKEMYHEAREPKHVAVSLAGEPTLYPAISELIDEIHTRGMTSFLVSNGTTPDTIREMSLP
TQLYITLAAPDEETHRRLCRPGIRGAWEKLIASQEALRSLDTRTVNRMTMVSGRNMRDPR
GYAKLILGGEPDFVEVKGYMHLGSSRERLSSDNSPTHREIRALSRNLAALTGYYLADEQV
ESRVVLLSRGKHINKIQGD
>A0A4R8TQ78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum sidae|TrEMBL
MAFSLDQPGLMVMLNDFHDVWQQVRIPVILFTLFGLFVLRLYYHSTEKKGELKALPKVYN
REKPETEPKGLAVDEKHVVNEIVAVEKKELKPIPVAEPKPAKSSGPKRIKGGLVKRPSEE
LKNSEVAQTIRPLIFFSSITANTPKIAKEYAERLGKDLEKTATDTGCQFKTPEVLDLAEI
DFDDYFITPPKSEEPVELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGY
SVFGFGDREGWPTEEEGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYSERLAEWSEG
VVDVLGLVAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLVEEDAKPEKLKNSSKLEDVE
DLGRIMKSSQPDSAPAPAAPIAVDFTTYGKSTTATKKPTQAAKEMVPKNSPTYASLTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPL
HRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYARLVEKGLPCFVEIKGV
TYCGTSTASNAGLSMSNVPFYWEVSEFVTALEKRLNEMGLKYGIAAEHAHSCCVLLASDR
FYKDGKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGKGGFDPRDERVDRK
GRKIEA
>A0A2Y9PA65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Delphinapterus leucas|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGASERGFDPKDTRYQRK
NKSKDISGC
>A0A7L4D6W1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eurystomus gularis|TrEMBL
LDASMDTWNFYTCLVSFWLHRFYIYSAVALGISIWIVIQFTTSKNKSEKSNGNPAASEGT
EGKLINGYATLQAKEVNVAGVKIFYGSQTGTAKRFAKCLAEAVSSLYLPVEVISMGDYDP
DDCLSEETTSRNICVFLVATYTDGQPTESAVWFCRWLEEAANDFRYGRTYLKGLRYAVFG
LGNSVYVDHYNTVGRNVDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLS
RLQALCRGEKKPCSGKCKKGKCKSPGKNKESSDHEHGASEYENAEAEELFETSSEEEADA
EEGGGTNSVVDVEDLGNIMSHMKKAKRQLEPDEGDVGTNLTRENAGRKEEDEKREMITPA
LREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPETILQEAIENHQNMIKQFRGVSGVKADRFEEAMTAKH
CALSLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDF
IEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKK
FKINGEWCTWINYDRFQELVREHERSGGAKTFTAADYAARTPPWALFGSRERGFDPLDVR
YQRKNKARDMSGC
>A0A8D2P6W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zosterops lateralis melanops|TrEMBL
MDSWSYFHACLVSIWLHRFYIYSAVAFGISLWAVVQFTTARTQKKGEKSHGNPSSPEGTA
DKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYDPE
DGLVEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTR
LQGLCKGEKKPCSGKCKKGKCXSSGKHSKESSDHEHGTSEHENTEAEEFFETSSEEEAGG
TDSVIDVEDLGTIMGHMKKAKREQELEEGAAGAGKKEEAERREMITPALREALTKQGYKL
IGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMY
PHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGES
SASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWID
YRRFQELVREYEQSGGSRTFTAAEYTARTPSWALFGARERGFDPSDVRFQRKNKARDISG
C
>A0A1E3QZ00|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Babjeviella inositovora NRRL Y-12698|TrEMBL
MDFTSAFQPKTPAAVNEALVAAVAGVALAPVPLKKAKRAPKVFKATAPVKTAKPAEKTVM
TKSNLMQSNYIIFYSSLTGSSLRAAKDLGVRLAELGIQRRLMSLDDDVDDLDEYFQNTPK
AEANSAGTVYVLILPSYEMDSPIDYFLETLLDTIQDFRIDSYPLAKLAGFAVLGLGDAES
YPEKFCYQAKIADKYLAKLGARRIFPLGQVCMKYKGDSGFEEWNRLLADTVQDEELVYVD
GDDASDEEYDYDNVGEDADTLVDVEDMGNYMASDNDTLEKKEMVAKDSPTYKTLTKQGYT
IVGSHSGVKLCRWTKSALRGRGSCYKYAFYGIQSHLCMETTPSLACSNKCVFCWRHGTNP
VARDKWRWELDSAQVVFDGAKAGHYSKIKQMRGVPGVQADRFAEAFQIRHCALSLVGEPI
FYPYINDFVELLHNEDISSFLVCNAQHPEQLAAMSKVTQLYVSIDAPTKDSLKKVDRPLN
RDFWERLNKCLDILRTTQADQRTVFRLTLVKDFNMEDINEYAELVERGRPSQIEIKGATF
CGSSAGNGNPLTMQNIPFYEECKNFVEALTANLQARGLPYEISAEHAHSCCILVADTKFK
IGGKWFTHIDYKRFFELLKSGKSFNDMDYVAETPEWAYYGSKEGGFRPDDVKWNRTEEKL
KNKKAREAQAEAQASKIEEVSIEGETPPEA
>A0A8J8DBM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. M36|TrEMBL
MALTFKSNPNMPEEIARLFKKQHYALVGRHSSVKLCHWLKESIKKDRFCYKQKFYGIHSH
RCLQMTPVTAWCSHNCIFCWRPMEGFLGTELPGPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQLYVSLTAPDTETYSRVNVPMVPGGWDKIKETLRLMGDADTRTVIRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVRHLPGY
HIEDEYEPSRVVLIMRDDVDSHGSGKNGRFLKH
>A0A1V5ZA93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon ADurb.Bin165|TrEMBL
MKALRGMGYQFFHPQSSAALKPCLWCKRSLSGGDQCYKNQFYGITSHRCVQLTPTLRCNH
TCLFCWRSFEHEYTGEKDLMPEEIVSRIPFLQKKALGGYKVSPRVAKEKWEEALRPDQYA
ISLAGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPGVLRQCHPYQKYISLTAPDRETYL
RIARPVEDYWDQILESISDLGHETDAGRRTAIRVTLVRGINDQDPERYARIIQESGAKFV
EVKAYMHVGYSQKRLTIRHMPLHDEIDRFTRKMLPHLSYRILGENTLSRVICLEQDS
>A0A5E4ACV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marmota monax|TrEMBL
MDRPLAAWDLSSPLLSLWMHRFYLYLGFAFGISLWICVQILIKKQGKNSQERSIPEAAQD
LMTNDYASLPKKHIFVSGVKIFYGSQTGTAKGFATILAKAVTSLDLPVAVINLKEYDPDD
HLVEEIASKSVCAFLVATYTDGRPTESAEWFCKWLQEASSDFRFGRTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGARRVLARGDGDCDAVRSKHGSIEADFRAWKTRFISRL
QALQKGETSCGGNCRRGKCESKQHGTEDEEPEPLALAAQQPRDTEEEEPCESSSEEEYGA
GEHQGRNSVVDVEDLGKVMDLVNKEKREEEQQEEKGLFGSRGKKEGGEGRAMLTPVLREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILEGAVENHLDMMKQFRGVPGVKAERFEEGMKVKHCALS
LVGEPIMYPEINRFLQLLHQRKISSFLVTNAQFPEEIRKLKPVTQLYVSVDASTKDSLRK
IDRPLFKDFWTRFLDSLKALAEKQQRTVYRLTLVKSWNVDELQAYAELVSLGSPDFIEVK
GVTYCGESAASSLTMANVPWHEEVVRFVRELVGLIPDYEIACEHEHSNCLLVAHRRFKIE
GEWWTWIDYGRFQELVQEYEDSGGSKSFSAEDYMAKTPPWALFGARERGFDPKDTRHQRK
NKSKDVSGC
>U3KHA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ficedula albicollis|TrEMBL
MDTWSFFHTCLVSIWLHRFYIYSAIAFGISLWIVIQFTTTRTKRKGEKSHGNPSSPEGTA
DKLGNGSAPPQAQEVHVAGVKIFYGSQTGTAKRFAQALAEAVTSLNLPVEVINMGDYDPE
DGLSEETSSRNICVFLVATYTDGQPPESAAWFCQWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLSR
LQALCRGEKKPCSGKCKKGKCKSSGKQSKESSDNEHRTSEHENTEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKREQELQEGAAGAGSKEEAERREMITPALREALTKQGYKL
IGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWRTDPPEVILQEAMEKHQSMIRQLKGVAGVKAARLEEALAVKHCALSLVGEPIMY
PHINSLVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISIGKPDFIEVKGVTYCGES
SASSLTLANVPWHGEVLSFAQELARLLPEYGVACEHQHSNCLLLAHSKFQVDGQWRTWID
YGRFQELVREREQSGGSRSFSAAEYTARTPAWALFGARERGFDPLHVRVPRRSKARLASG
C
>L0JKP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema pellirubrum (strain DSM 15624 / CIP 106293 / JCM 10476 / NCIMB 786 / 157)|TrEMBL
MSDSANPGGDAGADATADGDDGGPAQVSSPDYHSENHTAAQTCGWTANAVRGEGKCYKNI
FYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDDVEWDDPEAVVDASIRLQKKLLS
GFGGNDEVPGEVFDQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPE
VLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWERLLETMDALAAKDETRTVLRTTLVE
GENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSAMPDHEAVVEFAERVGEYMP
AFDEVKEVPASRVALLAKTGDTWVPKLKKGSEFWERDPVVGD
>W5U9P5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ictalurus punctatus|TrEMBL
MIIFFITLLTHALSFVSAAEMPGYLDNAWLYTEAFLAAVWRDRLYVYTAAALLIGLWLTV
NMTMKKKKLANLVKSPKNSKSEKQKEQIPEKEKVANVAGVRIFYGSQTGTAKGFARELAE
DAQVLGFESDVIDLKDYDPEDKLSDECTSKRICVFLMATYTDGKPTESAEWFCKWLEEAS
TDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAARVMSRTEGDCDVVK
SRNGSIQADFQAWKEDFLRRLQALAKGEKKACSCECKKGSCKSKKKHHEEAEDEKHSSEE
LFESSSDPESGGEEEKAHGSVIDLEDLGNVMNHMKKAKKVEEDSSQLGRLSKLNGLKKAE
PEETREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQEALENHRNMIRQFRGVPGVRP
ERFEEGLAVKHCALSLVGEPIMYPEINSFLRLLHQCHISSFLVTNAQFPEEIRSLVPVTQ
LYVSVDASTKDSLKRIDRPLFKDFWQRFLDSLKALGEKQQRTVYRLTLVKAWNVDELKAY
AELIALGQPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQQLASLLPDYDIACEHE
HSNCLLLAHHKFKADGEWRTWIDYERFHELIQKYNESNGAKTFTALDYMAKTPSWAVFGA
RERGFDPSDTRFLRKNKTKDISGC
>A0A6G1MMB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MAEIFKSRSPDLIELWHTIRIPLIIAIGVLYITIRLRSILRARTPVITAPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPVKSNADAPPAIERV
GENTQSNGKSIQVFIFYSSLTGSTAKYAEKLSNDLFSEPLHIPTPTPPSVDNAEPEPAVE
KATFLPPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFP
VGMGDVKGDALDSMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPPKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYADLVEKGLPAFVEIKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNEALQKRGLEYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTA
EEVAAELAAEAAEAESGCG
>A0A480UJ42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEASEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANGRYLLWREFSEQSYHGQRALARGSGAFCLGVGGSDPRLRNCL
RTRTFQLPPDSSQEV
>A0A4U0WYJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cryomyces minteri|TrEMBL
MPDAAELLYLWHTYRLPVLLAAVAVFALVRLTLRARGKREKTATTPPPGSPGPLSKDVKD
GGWPDVLGDSREGKDEVVSVSEQPPTRAKAGPKRVTGVIRTKTSPSRDAGFDLTRDELQP
LLFFSSLSGTTEKAASKLVADLQASTEAAPNVLPPKLLDLAYIDYDDYFIAPPKTSSEKR
SIKYFYLIAIPTYNIDTVLDNFLEHLRETHHDFRIDTAPLSALLGYSVFGFGNKEGWPTE
AEGFCSQAKEADKWMAKLTGRKRAFPLGMGDVNGDAAERFDEWGMGVEDVIRDISAGRGL
GEGVPGSGDAVESDEEDVEDAQDSEGDTQAQPKVQRPKKRADLGDLEDLGRSVQKDPSSA
PITIDFTTYSSSKKPTPVVKEMVPKSSPTYTALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEAIYAGVTA
GHYRKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTALLHADRISSFLV
CNAQHPDQLAALKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFTRCLDILRAKRLTQR
TVFRLTLVKGFNIDDEAEGYADLVARGLPCFVEVKGVTYCGTSTSAAAGLTMQNVPFYGE
VCAFVDALVAALARRSLDPPYGIAAEHAHSCCVLIASTRFLKPDGWHTTIDYDRFFDCLR
AGTAFAPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRPKGPQSVPVGGGGGRVLEVA
>A0A0D2R535|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium raimondii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAKTNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A7C4RA03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MITARTYIDDVDRLKKSGYRIIGRHSAVKICHWTKNVLRGGKHCYKSWYGVESHRCLQMT
PSLQYCNMMCIFCWRFHTINRIAVYEGEWDYPEEILDKLILEQRQLLSGFKGNPDVDKKL
FKEALEPNNIAISLDGEPTLYPYLADLIKLAHTRGMTTFLVTNASLPSRLENLINKDAQP
TNLYISLYGPDLETHIRICRPLIHDSWTRLNESIRLMPSFNRSRKVIRLTLIKGYNMKDV
EKYASLIKIARPDYVECKAYMHVGESQKRLPREAMPTMEDILDFSRKLSILINYKVVSND
MPSRVSLLADESSVYFSLDSDRIARGTQSISL
>A0A843FKF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MAFTKEEQAKLEYSGYRFVGEHGHAAAKICHWTRKSMVNEGVCYKEQFYGVQSHRCLQMS
PAVPFCNQKCSFCWRDLSQTRIEWEGEYDDPKTIIEGAIKAQNNLLCGFGGNKKADKKKL
EESKKPTNAAISLAGEPTLYPEIDELLAEFHRQDFTTFLVSNGMYWEKLGSLENEPTQLY
VSLDAPNEKVYKELCNPQINDAWSNLNKTLELMNSFDSRTAIRITSVKGKNMINTDEYAK
LINKANPKYVEVKAYMFVGSSRKRLSLDNMPSNQEVRDFAQEIADKTGRELTKESEVSRV
VLLE
>A0A6J3E6L1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aythya fuligula|TrEMBL
MDMWNFSYTCLASLWLHRFYIYSVIAFGISLWIVVQLFTTKKKGEKSNGNLSSEVVEEKQ
ANGYAAQQAKEVYVAGVKIFYGSQTGTARRFAKGLAEAVISLNLPVEVISMGDYDPDDCL
AEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSCLQA
LCRGERKPCSGKCKKGKCKSQGKQSKESSDHEHGASDYENAEAELVETTSEEEADAEEVG
GTNSVIDVEDLGNVMSHMKKAKRERELEEGHVGTSLSGETAGRKEAGEKREMITAALRDA
LTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVTGVKADRFEEAMTAKHCALS
LVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELRAYADLVSLGKPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVQELVELIPDYEIACEHEHSNCLLIAHKKFKVD
GEWCTWINYERFQELVREHERSGGSKTFTAVDYTARTPRWALFGSSQRGFDPLDVRYQRK
SKAKDISGC
>A0A6P5PSJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mus caroli|TrEMBL
MGPLDVWDFSPLLSLWMNRFYIYMGCALGLTLCICVHIIKKQVIGVTRSQEKSVPGAPDS
SLSPQKKQTHVSGVKIFYGSQTGTAKGFAVILAKAVTSLDLPVAIINLKEYDPDDSLIGE
ITSKTVCAFLVATYTDGCPTESAEWFCKWLEESANDFRFGKTYLKGLRYAVFGLGDSAYR
SHFNKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQR
GEKKACGRNCKRGKCESAQHGPGAARPHPQGELHPGDAEEEEPCESSSEDELGTQDYQSL
TSVVDVEDLGNIMNPVKREKREKAHQDGKAAMQRNPEKNEDGEGRAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEP
IMYPEINRLLKLLHQHGISSFLVTNAQFPEEIRKLTPVTQLYVSVDASTRDGLKKIDRPL
FKDFWQRFLDSLKALSAKQQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYC
GESAASSLTMANVPWHEEVVRFVRELVDLLPDYEVACEHEHSNCLLIGHKKFKIDGEWWT
WINYSRFQELVLQYEESGGSKTFSSRDYMARTPQWALFGARERGFDPKDTRYQRKNKTKD
ISGC
>A0A660HSV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina flavescens|TrEMBL
MRKVPMEEKERNTGEDFPEVQEENGGGESTSLPFDIPDFKTLLKKQGYALAGHHSAVKTC
LWLRHAMNGQGSCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDLPE
KIVEESIASQRKLITGYGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKISPSQLYMSLDAPDLETYLKVCQPRSPALWEEINESLSIMK
QKKLRTVIRTTLVKGENMFKPEAYARLIEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHE
EVLEFSKELAKHLRYEIADESEISRVVLLSKDGKKSPVRKLSCPD
>A0A384CPQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ursus maritimus|TrEMBL
MDPSLDTWDFSSPLMSLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSQEKSVP
KATQDLMTNGYISLQEKEVFVSGVKIFYGSQTGTAKGFAASLAEAAASLGLPVAVVNLKE
YDPDDHLVEEATSKNVCAFVVATYTDGRPTESAEWFCQWLEEASSDFRFGKTYLKGVRYA
VFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTK
FLAQLQALQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNPNSVVDVEDLG
KIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQLPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQEL
MQEYEDSGGSATFSAKDYMAKTPHWALFGACERGFDPKDTRYQRKNKSKDISGC
>A0A0F8LYR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei|TrEMBL
MPLEEKKEEQENFGENLPEVQEENTGEEPTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQSKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYIRVCQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEITDESEISRVVLLSKDGRKSPVKKK
>A0A662TIV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MIPEEVAKILRKEKYAIVGRHSAVKKCRWLHESLVNNRYCYKQKFYGIKSHRCLQMTPAV
IYCTHQCLYCWRVQKGDIGLDWEMPSEWDEPEIIVEESIKAQRQILSGYKVHKKVPYEKY
LEAIEPKHAAISLSGEPTLYPYLGELIEEFHRKGMSTFLVTNGTQPQRLAEITQPSQLYI
SLSAPDIETYKAICRPLSPKLWNRIMESIELIQSFTCPTVVRITAVKGLNMKKPERYAKI
ILKGNPTYVEVKAYMYVGLSRQRLKFENMPTHEEVKRFATQLAEELSYDIIDESEPSRVV
LLSRLKKPIKIGKE
>A0A151EDG4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon SM23-78|TrEMBL
MSKPKRKDLEKQGYRLVGNHSAIKVCLWTKKSLRDEGVCYKQKFYGINSHRCVQMTPSLP
YCTLRCQWCWRDIEHTLPRWVGKSEASEKIIQECIKAHIKYLQGFGGNKKTNKKKYIEAK
KPLHFAISLAGEPTMYPELPKLIKELKKQDISSFLVTNGTNPEMLKKLMDKKTLPTQLYI
TLPAPNEQVFKKMCSPLIKDGWKKILESLNSIKELKEKTRTTIRLTLTKELNMMYPEQYA
ELIKIAEPMFVECKGYVHVGYSKRRLEHKNMPRHNEIKEFAKELAKHSGYKMIDEQQASR
VVLLMKKDRKDRKLKF
>A0A6J1XYZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acinonyx jubatus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKFKIDGEWWTWIDYNR
FQELVQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A7TE79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)|TrEMBL
MELNKITSTLVGLLVSLYLYFGGRFSIAFSIVIVYSVVYDRDHGNYLGGKRETVVTTAVD
SLQSESKPKKKCCGGKNGGCCSTKSGAGSGGMKSSCCGGACKSKKLEDIADEIEKALAEQ
EEFEKKEQSTSFPVAVDFTQSFKPKSKGKKKKGPAKELKRFTKSKDDEKNDDLIKSAMTI
SNEKLLNSQIYVFYSSLQGAAERNAKIVHKTLSGMSELSKEPKLLCIDELDDLDDYFVEV
PDENSLYVFILPSYDTDCPLDYFLQTLEENFNDFRIDKYPLRKLVGYTVLGLGDSESWPE
KFCYQAKKTDHWIARLGGRRVFPVGEVCMKLDGDSKVEAWANLLADTLKDDEPILYEYDE
TVDDDEEEAGLEDIDATEDLVDLEDIGKIDGNSTEIKKMVAKNSPTYKQLTKQGYTIVGS
HSGVKICRWTKSDLRGTGSCYKQSLFNIVSSRCMEMTPSLACSSKCVFCWRHGTNPVSKN
WRWETDDPEYILENALQGHYSKIKQMRGVPGVIAERFAKAFKVRHCALSLVGEPIMYPYI
NKYVELLHEKEISSFLVCNAQHPDALRNMGKVTQLYVSIDASTKSELKKVDRPLYKDFWE
RMVECLDILKTSQSHQRTVFRLTLVKGFNMGDISSYADLVQRGLPCFIEVKGATFAGSSA
GNGNPLTMQNIPFYEECISFVKAFTEELNRRGLGYGIAAEHAHSNCILIASNKFKIEDEW
YTHIDFDKFFELLNSGEQFTHLDYMAKTPEWALFGNGGFAPGNTRVYRKGKNKNKHKEIE
AEIVKTTEPIAVAN
>A0A0B3ACG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeon GW2011_AR5|TrEMBL
MQIPIINNAMDENKSACQSGCNAIPEGFVDVPAELNSQIDKKFEFMRQKTTQMGYRFVGK
HSAIKVCHWTKESIRGKNACYKNKFYGIGSNQCVQMSPAMLTCTFNCRFCWRNFDYILPR
EKEEWDNPRQILDGCIDAQVEILQGFYGNPNADRDKLDKAMIPQHVAISLSGEPTLYPHL
PEFIDEIMGRKMTSFLVSNGTRPQMVEKLLQHQPTNLYISFYGTNPEMYRKAAVPMENNF
WENVNQSLKMLGKFDCSTVVRLTLAKGLNFTDPKGYAQIIDGTGAKFIEVKGYMAVGGSR
KSMKYEDMPLHSEIREFAAKIESNSGYRIISEKPDSRVVLLSREGKNFVGID
>A0A2J6TIH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyaloscypha bicolor E|TrEMBL
MAHETWVFRSRSWLPFEIADIVAVWHEYRIPILLSTFTLLMIFRTVLHLRSPRERIFYTP
QISPPLPTEKVRLLDDKRVNGEKNPRRIVGGLKKRKSSEDAAQSGVRKIQVLVFFSSLTG
ATEKTATAFTEDLAKSTKNLEDSATTFPEPQLLDLSYIDYDDYFITPPKGEGGTQFFYLL
LLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSRLLGYSVFGFGDREGWPTEEEGFCSQA
RDVDKWMAKLTGRKRAFPLGMGDSKMNAAERLREWMEGVGDVLGHIARTGGLGEGVVGSG
DAVESDLEDLDEEDEVLFDEQKIAQGKTKLQKNDVLNDLEDIGSTLNKSSVDPSEPLEVD
FTSYSKKTRPTPPPTVKEMVPKNSPTYNALTKQGYSIVGSHSGVKICRWTKSALRGRGSC
YKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFAGVKTGHY
QKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHAEHISSFLVCNA
QHPDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILRERRFEQRTVF
RLTLVKGFNIEDEAEGYAALVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVCA
FVLALNTALAKRGLEYGIAAEHAHSCCILIASQRFRKEGKWHTRIDYERFFECLESRQPF
RPEDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTESQGEVMGE
>A0A2I0PMW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriales archaeon HGW-Methanobacteriales-1|TrEMBL
MILTIEQRQKLEKMGYRFAGENYHAAAKICHWTKKSILDEGVCYKEKFYGIESHRCLQMS
PSIPFCQQKCFFCWRDLSSTDIKWEGPYDEPKEIIEDCIQAQKKLLCGFFGNEKANKKKA
MESGDPKNAAISLAGEPMLYPEIGELISEFNRRDFTTFLVSNGLTPSKLKELPQDPTQLY
ISLDAPEKDTYQKLCRPQIEGAWENLNDSLELLSTFDCRKVLRITAVREKNMFDPQGYAD
LIKKAQPDFVEVKAYMFVGYSRQRMALDNMPMFSEVKDFARDIGNLCGMEVVNESTESRV
VLLA
>A0A672UW28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigops habroptila|TrEMBL
MECDTALVSQEDKLVNGCATLQAKEVYVAGVKIFYGSQTGTAKRFARALAEAVISLNVPV
EVISIGDYDPDDCLLEETTSRNICVFLVATYTDGQPTESAAWFCRWLEEAANDFRFEKTY
LKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTCAEGDCNVAQSKHGTIEAD
FEAWKAKFLSRLQALCRGEKKPCSGKCKKGRCKSPGKQSKESSDHEHGASEYENTEVKPK
FMRPYFSFSAPWSYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQQAIENHQNMIKQFKGVAGVQAARFEEAM
TAKHCALSLVGEPIMYPEINRFVRLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLG
KPDFIEVKGVTYCGKSSASNLTMANVPWHEEVVHFVQELANLIPHYEIACEHEHSNCLLI
AHKKFKINGEWCTWINYDRFQELVRAQEQSGGSQTFTGADYAARTPHWALFGSRERGFDP
LDVKYQRKNKARDISGC
>A0A432HDF0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLINDRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLHKIDDDPYELFLESVRGHRRLLTGYGGNPKADPEKFREAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIERLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDKAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPDFIEAKGYVYVGNSRNNLVIENMPSHQEVLDFSHRLAPLVGREVLSDRRESRVALIGR
EMIPITLPEKVRELPRDLGIAKPQRYVLPQA
>Q2UHJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus oryzae (strain ATCC 42149 / RIB 40)|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNDQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRTIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>E1BL71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos taurus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALRKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHQSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>M4CHT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica rapa subsp. pekinensis|TrEMBL
MAFSSSIHSRLALIALLSATTFYCIHKYRRLKRLKTLSSKLNPSAATIRGKIFFISQTGT
SKALAQRLRDLLASNGVAFDLVDPRSYEPEDLPKETVAIFVASTWEGGKPPKDGEFLVDW
LSESAEDFRVGSLILSDCRFAVFGVGSRAYGEAYNAVGKELARRMVGLGGVEMVPVGEGD
VDDGEMEGVFRDWCDGVIRVLKGGSAREGAEILHNGDVGLVSDGEYVDSTDEEEEEEGNG
DIVDLEDIAGKAPSRKNGVVKVNKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKE
IVKGALDLHTKMIKQMKGVPGVTAEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGK
RISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
ADVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASG
EPFTSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQAVLA
>M3AP53|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudocercospora fijiensis (strain CIRAD86)|TrEMBL
QLPEELLLLWHAHRAEVILSAGVLLAIVRLALHWRRRKAEVVLTPLASPVDEKKAKAFPE
TQRVEKAAVRDEAQVKIQTKAKGPKRVKGIRSVKAKQNEAPAFDRIQPYVFYFSLGGSTR
AYAETLASNLPGQAKILPPVVYDLTDIDYDDFFISPPKQESSSTAAFYTILIPSYNIDTE
LTNFIDHLKETHHDFRIDTAPLSALAGYSVFGIGDRVEWPTEEQGYCTQAIEIDRWMAKL
TARKRAFPLGQGDAKGDDLELRLEEWSRGVQNIMQDLSEGKGLGEGAPGSGEALESGDEA
DDGDEGETLVPRKGDAADLEDMKAPIPVDFTTTSKKSGSPAEPKAMVPVTSPTYTSLTKQ
GYTIVGTHSGVKTCRWTKSALRGRGSCYKFSFYGINSHQCMEATPSLSCSNKCVFCWRHG
TNPVGTTWRWQVDEPDLIFDGIKAGHYQKIKQMRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPHINQLLAMLHAEHISSFLVCNAQHPDQLATLGPVTQLYVSIDASNKETLRKIDRP
LHRDFWERFIRCMDILREKRFTHRTVFRLTLVKGFNVDEEAKGYADLVERALPGFVEVKG
VTYCGTSTAAGAGLSMQNVPFYEEVAAFVVALEKELNQRGLEYGIAAEHAHSCCILLADR
NRFFKASMVDGIKRWHTIIDYPAFFRCLESGKPFAPEDYVGEATPEWALWGNGGFDPRDE
RVDRKGR
>A0A8J8ES06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. CX2|TrEMBL
MAIVVKSNPNMPEEIARLFKKQHYALVGHHSGVKLCHWLKESIKHDRFCYKQKFYGIHAH
RCLQMTPVLAWCTHNCIFCWRPMEGFLDVELPKPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGLTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKILRTLELMNGLPTRTVIRLTLVKGE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVRHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A851QT18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tychaedon coryphoeus|TrEMBL
DVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPGTADKLGN
GCVPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAITSLNLPVEVINMGDYDPEDGLSE
ETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSAY
VDHYNTVGRRMDRWLWMLSASRIMTRAEGDCSVAQSKHGSIEADFEAWKAKFLTRLQALC
KGEKKPCSGKCKKGKCKSSGKQSKESSDNEHRTSEHENTEAEELFETSSEEEAGGTDSVI
DVEDLGNIMGHMKKAKPGLGHWQGSRGSHSFSGHPVPGPAHPHREQFLPSYKLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWK
TDPPEVILQEAIEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINRFV
RLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLD
SLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISIGKPDFIEVKGVTYCGESSASSLTM
ANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWIDYGRFQEL
VREHEQSGGSRTFTAAEYMARTPAWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A842Q8Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MNPKLKQLLEKQGYRFSGNHSVVKTCRWTRNSLRGKGVCYKEKWYPPVKSHRCMQMSPSL
FCNHNCLFCWRLHSGDRGVSWKESFKGIKLDDPREILEKSIEQRKLLLQGYKGWEGIDKK
KWKESLKPNIIAISLTGEPTMYPRLGELIQEAHKKNIITFLVTNGTFPEKLKTLEENPFQ
LYVTLAAPNKEVYKNLCKPSTPKLWEKLNETLELMNSFDCRKVVRLTMVKGFNMTKPKEY
VKLIEKINPDFIEAKGYVHVGESRKRLPHDAMPYHEDVRDFSKELEKASSFEIKDESEPS
RVVLMT
>A0A497T9M3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MNLSAFTKRHYKVWEHTAVKLCHWCKLSLKDRGFCYKQKFYGIQSHRCLQFSPAFLWCTN
DCLKCWRPREWESNLPEWREPEEVLEFCLEAQKQLLSGFKGFSGTNLQKWKEAQRPNQAA
ISLIGEPTLYPKIGELIELLKSRGFTAYLVTNGMLPERLSDLPEPTQLYLSLDAISAETH
RKLNRSRLPDAWERMLKSLELLSSFKRTVLRITAIKGLNMGWADEFGRIISRYQPKKVEV
KAYMHLGHSRKLLPREAMPDHQEVRQFAEEIAKKAGYRILDEQEVSRVVLLG
>A0A5N6IRK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus minisclerotigenes|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKASTGNDPAPNVVSGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVALNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A0D2FW13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phialophora americana|TrEMBL
MDMGEGAAPVVILADWLDRLLTLWHDNRIVLASVTFLSVLAIIARRRRAGRIVLRESSPG
LEKAEWLAAADDDSARHATNEKNKTASRHVDQLTSGQARKPRPAAARTVTGRKPVGPRGQ
TLAQRQTGPSYLQPLVFFSSLTGTTERLSKKVAAELEALATTHPTILKPEVHDLSYIDLD
DYFISGPKTPKPAANVRHFFLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLAGY
TVFGIGDKEGWPTEEKGFCSQAVEVDRWMAKLTGRKRAYPLGLGDVKSNIEQATKEWTGG
VCDVLRELNVSGTLGEGVPGSGFAVESDQEDEPDAGYDNDVDFPDSGRNKRRKLANTTDL
EDVGGKSTPMAIDFTTYSTTSASAPVALKAMVPKESPTHAALTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDP
KMIFDGAKEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLH
GERISSFLVCNAQHPQQLSDLRRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNSCLDI
LREKRFEQRTVFRLTLVKGFNVEDEVEGYADLVAKGLPCFIEIKGVTYCGTSTSSSAGLT
MQNVPFYEEVVAFVEALDAALVKRGLDYSIAAEHAHSCCALIASKRFLINGKWNTIIDYD
KFFGLLEGGQDFKPEDYCQETPEWALWGNGGFDPRDERVDRKGKPKAASKTDELARGRKA
GPVVDAPSGGLDF
>A0A8H4CG33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum gloeosporioides|TrEMBL
MASPLDRPGILSVLNNFHDVWQEIRIPVILFTAFGLLVLRFYLHSVEEKDELKAFPKALN
REKPESKPLPKPIDEKKDAKPSPVVEAKAPKSNGPKRIKGGLVKRLSEELKDGEVLARTV
RPLIFFSSITANTPKIAKDYAERLEKELEKVTADTGCSFNTPEVLDLAEIDFDDYFITPP
KSEDPVELFYMFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREG
WPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYVERLSEWSEGVVDVLGMLAK
TGSLGEGLPGSGAPEESDDESAAEDDDEVLIEEDAKPEKLKSRKNIDDVEDLGRIMKSSN
PDADTKSAAAPIAVDFTTYGKSASAPKKTPTNAAKEMVPKNSPTYASLTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINE
FLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERF
QRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYCGTSTA
SNAGLSMSNVPFYWEVAEFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKDGKWH
PRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>R7VVA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Columba livia|TrEMBL
MDTWSFYTSLVSLWLHRFYIYSVVAVGISIWIIVQFLTTKTRKKARTEDKLVNGSATLEA
KELCVAGVKIFYGSQTGTAKRFAKGLAEAVISLCLPVEVISMGDYDPDDCLAEEVTGKKK
FLVATYTDGQPTESAAWFCKWLQEAAHDFRFGKTHLKGLRYAVFGLGNSVYVDHYNTVGR
NIDRWLWMLGASRIMTRVEGDCNVAQSKHGSIEADFEAWRTKFLNRLQALCRGEKKPCSG
KCKKGKCKSPGKQSKESSDPEHGASEYENTEAEELFETSSEEEADAEEAGGTNSVIDVED
LGNIMSHMKKAKRDCELEDGDVGKNLAQENSGRKEESERREMITPALREALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHCCMEATPSLACANKCVFCWRHHTNPVGT
EWRWKMDQPEMILQEALENHRNMIKQFKGVSGVRADRLAEAMTAKHCALSLVGEPIMYPE
INRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFRDFW
QRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSA
SNLTMANVPWHEEVVRFVQDLADLVPDYEIACEHQHSNCLLIAHKKFKVDGDWFTWIDYG
RFQELVREHERSGGAETFTAADYAARTPEWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A1I8HU76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
QSASKMSHWDLTVHISRALQNSSALSYSLLLAASVVGAWILFQRRGRQGHVISASSVKKA
VLSSSSQMSLRSPTTRKAMLPTTSCTSTANGSVDETFNKVRVFYASQLGRAKHFATLLLA
ELAGVLKQQKQQQQSLSVATVATSPDTLCYFLLPTYEGGSPPDTGAWFCKWLAEAAEDWR
VERGHLSGLRFIVIGLGNSLYAENYNLIAKRVDEQLTQLSGTRLRPPVLLDENVASATGH
GGQEADFQAALQSQLLDPLVSKKNKSACCSEATGNSACCQGAEAASDVAEDHSDVDNDNL
DEEDQEGLVDVEDIGGVLSSATRSNQKQKLGQEATTRRAMVTPLVRKSLEKQGYRLIGSH
SGVKLCRWTKSMLRGRGGCYKHAFYGIASHRCMEATPSLACANKCVFCWRHHTNPVGTEW
RWLEDPPDEILSGALDAHRRMIREFRGVPGVMPERISEGMQPRHCALSLVGEPIMYPRIN
QLLHLLHTSGISSFLVTNAQFPEAMRQLPPVTQLYVSVDAATPDSLKRIDRPLFKDFWQR
FIDCLRAMRDCGQRTVYRLTLVKAWNTEEVQQYAKLVDLGCPDFIEVKGVTFCGDSKASQ
LTMGNVPWHKEVVQFSQALADSLANQYDIACEHEHSNCVLLANKRKFLVNNRWHTWIDYD
RFEQLYGRFVETGQRFNAADYMAETPEWAVYGSAEQGFDPNETRFRRRAAAAAAAAAASG
DY
>A0A847T047|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccus sp|TrEMBL
MTDDMNRAREKQQYKMHGGHAAVKLCHWMQQSLLKGRPCYKEEFYGIRSHRCLQMTPVVN
QCSHNCLFCWRVQGFEGKVERWSEPEAMLDACIEEQRKLVSGFGGDQRCSREMWKEAREP
KQVAISLSGEPTLYPYLGDLIELCHRRGMTTFLVTNGTYPEVLEKLHPLPTQLYVTVAAP
NVEVYKRLCVPRQPDGWERLMRTLELFPSLDTRTVVRHTLVKGWNMGWEDEYARLDSIAD
PMFIEPKGYVFVGDSRRRMHMDNMPSHADIVEFSRRLGERLGMDILKERKDSRVLVQGRD
ESRLRIPGL
>A0A8C5G3I7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
MSSFKNGVKWAVPCISLVLNTDVYSGSEKYLLWVWHNRLYLYTAAALCFGLWFSLKMVLK
KKSVPSDLVLWVQKSAEKNDRAEVHVSGVKIFYGSQTGTAKGFAAELSEEVKTLGIPSEV
IDMKDYDPDDQLADECTSRTVCVFIVATYTDGRPTENAQWFCKWLEEASTDFRYGKTYLK
GLRYAVLGLGNSAYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQDDFL
AWKAHFLRRLQALARGDSGSRSSKSSCMKTDGADHEGEEPTLTNHSSEEELMETSSDEEQ
SDERTSGSVVDVEDLGNLMDSVKKSKVPETHVSVIVFYSFIKGERKGSNKEGASREMITP
TLRNALTKQGEKQPGQMLQMLQWEGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWLWKMDPAEKILEEAMEKHQNMIRQFKGVPGVLPERYQEGLAIKHCALSLV
GEPIMYPEINTFLRLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGV
TYCGESSASTLTMANVPWHQEVVAFVRQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGE
WRTWIDYERFQELVEAHEASGGTRSFSALDYMSQTPHWALFGAQEQGFDPADTRFQRRNK
TKDVSGC
>A0A8C5E2Q1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
RVFLCCDVCVISRCVQGFAAELSEEVKTLGIPSEVIDMKDYDPDDQLADECTSRTVCVFI
VATYTDGRPTENAQWFCKWLEEASTDFRYGKTYLKGLRYAVLGLGNSAYVGHYNTVGKNV
DKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQDDFLAWKAHFLRRLQALARGDSGSRSSKS
SCMKTDGADHEGEEPTLTNHSSEEELMETSSDEEQSDERTSGSVVDVEDLGNLMDSVKKS
KVPETHVSVIVFYSFIKGERKGSSRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWLWKMDPAEKILEEAMEKHQNMIRQFKGVPGVLPERYQEGLAIKHCALSLVG
EPIMYPEINTFLRLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVT
YCGESSASTLTMANVPWHQEVVAFVRQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEW
RTWIDYERFQELVEAHEASGGTRSFSALDYMSQTPHWALFGAQEQGFDPADTRFQRRNKT
KDVSGC
>A0A8J5LJ93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zingiber officinale|TrEMBL
MVGIVLASLPSPRLALFAFLSATSLYFLWKSRRCRLQPSASSLKPANPSPRGKILYASAT
GTSRSLAGRLSARLRSHGLPFDLVDPRRYEPEDLPKENVVLIVASTWEDGRPPPDAQFLS
RWLAESAADFRVGSLLLARCRFAVFGVGSRSYGDSFNAAAKDFSKWMRALGASEMAPLWE
GDMDSGDVDDVFELWCRKIVGLLKGDSVAEDGHFDSMAENNGLEVSDEDSDEETEVEDLE
SAVVDMEDIAGKAPSRKLAVAPTNGRENGVRDMVTPVIRTNLEKQVNYVDLSSGYKIIGS
HSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WQWKMDNPLEIVDAVVSEHTKMIKQMKGVPGVKTERLSEGLSPRHCALSLVGEPIMYPEI
NALVDELHRRHISTFLVTNAQFPDTIRMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWE
RFLDSLKALRDKEQRTVYRLTLVKGWNAEDLDAYANLLSVGKPDLIEIKGVTYCGSSATS
KLTMDNVPWHSDVKAFSEALARKSSGEYEVACEHAHSCCVLLAKVDRFKINGEWHTWIDY
DRFHELVVSGKPFRTEDYMARTPSWAIYGAEEGGFDPYQSRYKKERRHGTASLRN
>A0A2V2Y1M2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MTIRLQAVRDPYKEINDKLRSQKYHLIGSHSAVKKCLWTHKAIYEGKYCYKGKFYGIESH
RCIQSSVSTQWCWNACMHCWRLRPTDMLDEWDEKSIVGIDDPRFIVEMSIIEHRRTVSGY
KAHGVPAHVIREAMNPRHVAISLTGENTLYPRLGELIKEYHRRGITTFLVTRAVRPDILA
NLDEEPSQLYISLETYDEEGYEFFTAPLVANAWRLTLETLEMLPSFTCPTVIRITAVKGW
NMDEKAVKGFSKLIEISMPTFIEIKAYMHIGTSITRLSRENMPTHEEVVRFAEELAKETG
YRLVSQSKPSRVALLSLIDKPVIRHGDAKISWWDPDYEGEDEYEGQSIYGALITK
>A0A7C5XBG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MDLELVKLKREKFWNNNPVYKAIYDRLSKQGYHIVGTIGAVKRCHWSKEAVLRRRFCYKC
LWYGIESHRCVQMTPVVVWCWNRCLHCWRIQPEDIGMHWDDTRPPIVDDPEVLVEESIRV
HRQIMAGFKGNPRADRELVEEALNPRHAAISLAGEPLLYPRLGELISEYHKRNVTTFLVT
HGTRPDVLKNLEREPTQLYISFEAWDKNSYEYFNRPLVPRAWELFQETIEYVRSFKSPVT
FRITLIRWFNDHEEALRQFAKFIERGYPHYVEVKAYMYLGVSKGRLSRDNMPTHKEVREF
AKKLSDITGYKLLSESVPSRVVLISRVEKPIRHGTGCPGGVECPEKYAPVITEEYEEAEA
>A0A8D3D0A5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MALKKKSFSEDVGPLVYKAVTNSDRSDRDTVVHVSGVRIFFGSQTGTAKGFANELSEEVK
TLGIPAEVTDMRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEVMTW
DDPLIKYQNFKTVKTITSKEEGGGGGQVVKLSKMNGVKKIEDEGEKREMITPALREALTK
QGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVG
EPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVT
YCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVAGEW
WTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPGWALFGACEQGFDPADMRFKRRNKA
KDISGC
>A0A4Q4URJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. MG133|TrEMBL
MSATFWESVADGNRGLTAVLFAVWLYLRLSQRQTESAGSPKLESGKSLPTELPAEEKVSL
PAAKESSNGPRRIKGELRKADDPKSAVQPDPQRRVQILVFFSSLTGSTERTAKQFTATLE
ASLLDQTSGSDQAFLKPQLLDLTQVDYHEFFISPPKPAEVSQPVDYFYLILLPSYNIDTI
NDNLLEHLKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQAKEVDKWMAKL
TGRKRAYPLGMGDSKRDLKERLGEWTEGVTEVVRQIAKTGCLGDGVPGSGDAVESDDEYV
SGEDDDGEVVVDESVQPKKTKKSTRGIDDVEDLGKIMKTSRADANDATGRAPIAVDFTTY
SKTSKKPPQTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKM
MRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHGERISSFLVCNAQHPEQ
LAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDVLRERRLRQRTVFRLTLV
KGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSGGKDGGLSMANVPFYAEVTAFVE
ALDRTLRERGLGYGIAAEHAHSCCVLLASERFRVDGRWHTRIDYDRFFELLEERGPDGEW
TPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A256ZKV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon ex4484_2|TrEMBL
MELLNERAKKILKKQHYRLVGRHSAVKLCHWTKKSLLDEGYCYKQKFYGIQTHRCLQMTP
SVLWCTQKCVFCWRKIEETIGAEIKKGGLDEPGEIIDGAIEAQRVLLAGYGGIPDRVNQR
KLREAQNPNQTAISLSGEPTVYPMISGLVEEFNRRDFTTFLVTNGTLPERIRDMDSLPTQ
LYVSLEAPNRELHRRICNPIIPDAWDMINETLSLLPSLDTRKVVRLTAIKGLNMIEPREY
ARIIAGAEPDYVEVKAFMLVGGARNRLTLDHMPSHEEVMGFASLLAEELSYKIKDEKKNS
RVVLLSKK
>A0A3A3A1C3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus sclerotialis|TrEMBL
MGSHCLGSLSEGLLAFWHSYRIPLLIVLSTTIFLVQAYRKFPSKSKTPASSSTPPSPRSS
SPEKHEKISVTNSRGSPEKAGPKVVSGPKRVVGKKPVKTGPPVAREPLSFIQPMIFFASL
TGTTERYAKVLQEDLRDAAQRRADPDNRERGLLPPQLHDISYIDFDDFFTSAPKAPLNSP
GTRYFYCLLIPTYNTDSILNTFLGHLDETHHDFRIDTGSLSTLAGYSVFGFGDKEEWPTE
EEGFCSQAKELDHWMAKLTSKKRAYPLGFGDVKGNAEQSLKEWTHGLQDIFFDILEHGGL
GEGVPGSGDPLESDEEDLDEEEPSDNNAKSRKRNKPQAVMDLEDIKMNSGNQAASPLPVD
FTTAGKPPAPENTPKEMVPKTSPTYNALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYK
YSMYGIKSHLCMEATPSLSCSSKCVFCWRHGTNPVGTYWRWQVDPPEMIFNGVKEGHYKK
IKMLKGIPGIRAERFTEAMRIRHCALSLVGEPIFYPHINQFLDLLHGEHISSFLVCNAQH
PDQLQNLQRTTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRDQQRTVFRL
TLVKGFNIDDEVVGYANLVEKALPCFVEVKGVTYCGTSSSAGAGLTMKNVPFYEEITEFV
LALNQELERRGLKYGLAAEHAHSCCVLLASERFRVNDKWHTRINFDRFFELLEKEKADGT
PFTPEDYMAETEEWALWGNGGFDPSDERVYRKRKNKAQVTEE
>A0A673KAH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
IAQGIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLEEASTD
FRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSR
HGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHSLAEKNN
SEEELMESSSDAESSSEEEKFHGSVIDVEDLGNVMNHMKKAKVKTKPEQFCLCINETNAA
FLLLVNAERERRLLACANKCGFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQF
KGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEI
RSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAW
NVDELKAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPD
YEIACEHEHSNCLLLAHHKFKVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKT
PSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A257ABK8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ex4484_138|TrEMBL
MSHEIQELLKKHGYQRAGRHSAVKTCLWLKRSINNKGQCYKSQFYGITSHRCIQMTPTLQ
CNQRCLHCWRAIDATIPKTPWDPPEVIVDETLRAQQRLTSGYGGSDQANKKLWEESKNPL
HVAISLAGEPTLYPYLSELINIFHKKGMTTFVVSNGTHPEVIREINPTQLYLSLTAPDRE
TYQQTCKPEREEMWEDLLKSLKILSGKKGRTTIRITLIEGLNDTKPEEYAKLIKLAKPDY
IEIKSYMHLGFSRKRLERNKMPTHTKINKFAQKIIEHTEYKWADENEPSRVVLLSKDGKT
DKL
>A0A673K3X1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
DPLFYIDLCKRYSRAFTGVLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGVCFTMNMLFK
KKKTVDPVSPWLYKSAKKQELSAETEKVIHVSGVKVFYGSQTGTAKGFAKELAGDVSAQG
IQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLEEASTDFRYG
KTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSV
QADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHSLEELMESSSD
AESSSEEEKFHGSVIDVEDLGNVMNHMKKAKVKTKPDSQRVKLSKQNGVRKSESEEEQRE
MITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSL
ACANKCGFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQFRGVPGVRPERFEEG
LTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVD
ASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIAL
GQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLL
LAHHKFKVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFD
PSDTRFQRKNKTKDISGC
>A0A8B8ZG73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phoenix dactylifera|TrEMBL
MTATSHSFSLPSRLALLALFSLSSSFFLWKSRRLRLLRLSSQNPNRDPSPRGKLFFASQT
GTSRALAGRLADRLRAAALPFDLVDPRGYEPEDLPKETLVLIVASTWEDGKPPPNAEFLA
RWLAESAEDFRVGSLLLSGCRFAVFGVGSRSYGESFNATAKDFSGWMRAVGAAEMLPVWE
GDVDNGDMDEVFDSWSQKVIGLLKGDVCENGGHLASIIESNGFDSEEEEEEEEEAMESAV
VDVEDIAGKAPSRKSTGALSNGGQNGDNGLREMVTPIIRTSLEKQGYKIVGSHSGVKLCR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDDP
LVIVNAAIDQHTKMIKQMKGVPGVKQEQLLEGLSPKHCALSLVGEPIMYPEINSLIDELH
SRHISTFLVTNAQFPDRIKMLRPVTQLYVSVDAATKDSLKAIDRPLFSDFWERFVDSLKA
LRDKEQRTVYRLTLVKGWNAEDIDAYANLLGIGKPDLVEMKGVTYCGSSATSKLTMENVP
WHSDVRAFSEALAIKSSGEYEVACEHVHSCCVVLAKVSKFKVKGQWYTWIDYERFHELVA
SGKPFKSEHYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAASIRGSPVAP
>A0A446TGJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSIALRRLRRTLRPSPSPSSSSPAAAXXX
XXXXXXATGTSKALAERLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEDDAVDGETNGFDGLEGEESDYDD
DDDEEEEEEVASGEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQ
GYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGE
PIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRP
LFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTY
CGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGK
WHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAAL
KG
>A0A7C4B8F0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum pendens|TrEMBL
MAVTLDVQRYLRAGYKLVGSHSAVAICRWTRSALRGERFCYKSWYGIKSHRCLQMTPVLN
FCDFACKFCWRMHLPGRYQVPRGWRWDDPREVLDKSIIAQRLLLIGFKGNPLVTRERFLE
AMFPRHLTISLDGEPLLYPGLAGLIREAKERGFTVFLVTNGSIPARLRELLKKDAQPTNL
YLSVYGPNKEVFERTADPRIPRAWEMVNESLELLGEFRDSRTVMRLTLVRELNMVEPEGY
AKLARRGEPMFVELKGYTWVGESQKRLPITAMPEMKELVDFASKLSELTGYQVKLTDDKS
RVVLLVRDEESWERNLKIVEEWRRKERELDERVLGKIEDFTMEEHGYKILRY
>A0A4W6CX60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDPDD
QLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLG
NSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRL
QALAKGEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAALQNVSSEVSELSSSVFLHGTLCL
LSESLILLTCCSLSFPAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQFRGVPGVKPER
YEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLEPVTQLY
VSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSE
LIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHS
NCLLIAHTKFKVEGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPSWALFGASE
QGFDPADTRFQRRNKTKDISGC
>A0A832TZR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp|TrEMBL
MPLEEKKENYVKDFSGFQEENRKEDTALLPFDIPDFKTLLKKQGYALAGSHSAVKTCLWL
RHAMNDQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPEKIV
EESIVCQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKKRGF
TTFLVTNGTVPEMLAKVSPSQLYMSLDAPDLETYLKVCQPRSPVLWEKINESLSLMKQKK
SRTVIRTTLVKGENLFKPEAYARLIEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVI
EFSQELAKHLGYKVADESEISRVVLLSKDGRKSPVNGKNLLITDKIS
>A0A1F9ZVK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon RBG_19FT_COMBO_56_21|TrEMBL
MDSRTRAHLEWQQYRIVGNTGAVKLCHWMRQKLIYGRPCYKEEFYGIESHRCMQMTPSVN
ICNFRCLFCWRYHGMTGFEKSGYPEPEQLLEECMKEQALLVSGFKGDPRCASRLWDEARI
PNQVAISLSGEPTLYPMLGEFIELCKRKGMTTFLVTNGSVPKVLAELSSMPTQLYVTVAA
PNKDLFDRLCVPQTTRAWENLMETLELLPSLSTRTVIRHTLVDGWNLGWEKEYARLDEMA
KPFLIEPKGYVFVGDSRTRMNASNMPSHACVREFSSRLAEELSLEIIKEREDSRVVLIGR
KGSRLGVRAREITST
>A0A168A8H5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sporothrix insectorum RCEF 264|TrEMBL
MASTSWVTSPSLRTLVEAAADAWHDYRVPLLLSLFTALLVLRVYLHFADPSEEKDGLLVF
PKLYGANETADTKQRGEKSAGETNPTVTSAERSIVGAKQNRIVTAGAAGKVEAAAAAAVP
GVVAKVGTKSSAAKPGPRRIKGEPHRQNRAATTAEAAALPSKIQTLVFFTSLTGATAKTV
GDYVKTLHDALQALELPDGRRTVFLPPKTLDLAEVDLDEYFIAPPTRQDREEDSVGHDGD
DTPVDYFYLFFVPSYNIDTINDTCLEHFKETHHDFRIDTAPLMPLLGYSVFGFGDREGWP
TEAGGFCFQALEFDKWMAKLTGRKRAFPLGCGDVKSDATERLAEWSTGVVDVLGLLARTG
SLGEGVPGSGDPVESDVDDDDDDEEVSDGDDAQYEDDEVLFGGDAARTTNMKRLKKAGVI
DDVEDLGRLLQDSKESTGDSKAGSNNGVVSAPIAIDFTSYDAVGGGNSNGRPRRAGRKEA
ATSASSPPQTTVKEMVAKDTPTYKSLTKQGYAIVGSHSGVKICRWTKSALRGRGSCYKFS
FYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFNGVKANHYAKIK
NLRGVPGVRAERFAEALRIRHCALSLVGEPIFYPHINEFLGMLHGERISSFLVCNAQHPD
QLAALHHVTQLYVSIDATNRESLRKIDRPLHRDFWERFQRCLAILRENRFRQRTVFRLTL
VKGFNLEDEVRGYADLVEQALPCFVEIKGVTYCGTSTSAGVGLTMANVPFYHEVCEFVVA
LEQELQRRGLGYGLAAEHAHSCCVLIASERFKVDGRWHTLIDYDKFFALLQAKGPTGDFA
PEDYMGPATPEWANWGNGGFDPRDQRVDRKGRPIAAK
>A0A314YHQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus yedoensis var. nudiflora|TrEMBL
MPLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSPSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNDLAFDLVDPNHYEPEDLPKETLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGASEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGDDDDEEEDDVESEVVDLEDIAGKGPSRRRTVTVTKTNGM
VNGKKEMVTPVIRASLVKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAIDLHSKMIKQMKGVPGVTL
ERLTEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTFLVTNAQFPEKIKMLKPITQ
LYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLKEKQQRTVYRLTLVKGWNTEDIDAY
YNIFSIGNPILLKSKELHIVDRLLHQS
>A0A2I0NL19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedenaceae archaeon HGW-Methanoperedenaceae-1|TrEMBL
MTEISESTKELLAKHGYHIAGTHGAVKTCLWLNRSMRNEGGCYKSQFYGMASHRCIQMTP
TLVCNHRCLHCWRAVEAPVPKPVKWDSPEEIVEGCLSGQRRLISGYGGSETSDSTKLKEA
HDLKHVAISLSGEPTTYPYLPELIEEFHKRGMTTFVVTNGTNPEMVGQITPTQLYMSLNA
PDADTYKKACAPLSDTWENIKQSLEIMKGSKTRTAVRITLTKGVNMANPVGYARLIGTAE
PDYVELKAYMHLGFSRKRLSRENMPDHNEVLDFSRQVAQEMGYQIADESRLSRVVLLSRD
GKKQDIT
>A0A7K5MZV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chroicocephalus maculipennis|TrEMBL
LNVSMDTWNFSYTCLVSLWLHRFYIYSVVAFGISIWIIIQFFTTKTKKKGEKSNGNPAAS
EGIKDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFAKSLAEAVISLNLPVEVISMGD
YDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAVNDFRFGKTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKVK
FLSRLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDHEHGASEHENTEAEELFETSSEE
EADAEEAGGTNAVVDVEDLGNIMSHMKKAKNHLPWQGHREAVAELMGREEPACAFGRVLI
YFLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCAL
SLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFVEV
KGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLMAHKKFKV
DGEWCTWINYGRFQELVREHERSGGAKTFTAADYAAKTPRWALFGSRERGFDPLDVRYQR
KNKARDISGC
>A0A7L0J5N8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Piprites chloris|TrEMBL
QRFAKALAEAVTCLNLPVEVINMGDYDPDDCLAEETTSRNVCVFLVATYTDGQPTESAAW
FCKWLEEAANDFRVGKTYLKGLRYAVFGLGNSVYVDHYNTVGRRMDRWLWMLSASRVMTR
AEGDCNVAQSRHGSIEGDFEAWKAKFLTGLQALCRGEKKPCSGKCKKGKCESPGKQSKES
SDCEHGASEHENTEAEELFETSSEEEADAEEAGGTNAVIDVEDLGNIMGHMKKAKVLLFL
TEALMLNPFGYPLVCFMSQLLQGKISSSLSFALFSGYKLIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEN
HQNMIKQFRGVSGVKAARFEEALTVKHCALSLVGEPIMYPQINRFVRLLHQNSISSFLVT
NAQFPEEIRSLEPVTQLYVSVDASTRESLRRIDRPLFKDFWQRFLDSLKALAEKEQRTVY
RLTLVKAWNVDELKAYAELISLGKPDFIEVKGVTYCGESSASSLTMANVPWHEEVVGFVQ
DLAELLPDYEIACEHEHSNCLLLAHTKFKVDGEWFTWIDYERFQELVRERERSGGSRTFT
AADYTARTPPWALFGARERGFDPLDVRFQRRNKARDISGC
>A0A3S5IRA8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma rangeli|TrEMBL
MIDVPTDMLLWALLGALLPVFTMTIASLLGRWSLHREKQKMQKMGQQAQADATSAMDADA
GSTREAKRSCSCQASVNGGKDEGAGKKILIAYATQSNTACTLAHKLFSTLNTVLHEASCE
EAQQGSVCCRGGRYVPEVKVLQLAEEGRQCSVDHLLESHAYSFVVLIASTYTNGTAPGSS
QAFADLLQDAYTDFRVPRDALAKTRFAIFGLGDVAYGAKHFNRFAKNLYTWCNGLGASFV
VPPVYASEANTVSLFNVFTASLVKWVSRVVFTADGVVVMRKPQRAKGTRSPTGDDAASLV
RAAPDSEDEEEEEAGNESRGGGKMLNNSRSNTNESAGDVEDVVTDDDDGGTEGEASMTSA
SDPQELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIASHQCME
MTPSLACANKCVFCWRHHTNPVSRSFRWKVDPPQQLVAGGIEGHQKMIKQMRGVPGVTPE
RLEDAMQVRHCALSLVGEPIMYPEINAFVDLLHERGISSFMVTNAQFPEQLRMLKPVTQL
YLSIDAPTPEELKRIDRPLFEDYWERCLACIRELRRKPQRTVFRLTLVNQYNTENVAAYA
HLVRLGWPDFIEVKGVTYCGTSATSTLTMKENVPRHEEVVRFCADLCAALAADTAPKDKR
TWLGQEPEPATARAKFNSNENKTSDNSKENNTNENTTEEGGAAAAASSGPYCIACEHEHS
CCVLIALRRFLVQGVWHTWIDYDKFTALARSGRTDFTAAEYAAPTPSWAVFRSNEKGFDP
TQLRVHRKSGKPVVVTSGC
>A0A0E3P004|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. MTP4|TrEMBL
MENQNQDQSSGKPPLPFDIPDFETLLKKQGYALAGSHSAVKTCLWLKKAMNDEGFCYKGK
FYGVASHRCLQMTPTLLCNQSCLFCWRPTEVPVPAPGEWDSPEKIVEESIACQRKLITGF
GGSPNALKERWLEGNDPNNVAISLSGEPTMYPYLPELIEEYEKRGFTTFLVTNGTIPGMF
AKVNPCQLYMSLDAPDQATYLKVCQPKSPALWDKISESLALMKEKSSRTVIRITLVKGVN
MFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLERSAMPAHAEVLEFSEQVAKHLGYEI
ADESEISRVVLLSKDGKKSPVRKKTLEENKET
>A0A7K8C3D0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhagologus leucostigma|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVGEDLLQELGA
DKLGNGCVPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVVNMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKVLLLEGVWNALLGSEKVSGTCRHLGVDFLGLMIFALFSG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALSVKHCALSLVGEP
IMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
>A0A7J9NS97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLDLDDMVKQVELLDMGKILSENSIFKIEDDSPESRVVLLTN
KNRKINPKIDFGF
>D4B2V4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)|TrEMBL
MAAILLQTVTFLAVTEFSSQRKQENQSKGAEQVIQKTIVSDKPAQPENTTLAKSTSLKRE
TKPGPKRLRGLRPLKGDANVTAQVVSAIRPIFFFTSLTGTTEKSARAAFESVKSKLQGAP
QNAQCKVLEPELHDLSYIDFDDYFVTAPKPPTSEPGLSYLYCIILPSYDIDSIINNFLNH
LDETHNDFRIDTSPLSGLTGYCVFGFGDKEGWPTVEEGFCSQAVAVDKWLAKLTGKRRAY
PLGFGDAKTDGDHSLQEWCDGIVSVLHDISENGGGLGEGVPGSGDPIESDEEDAEGDNQR
PHNSSRPRRTKARNSQVADLEDIKFNPKDLLDDEPIDFTTYAPTKISSLFSKEMVPSTSP
TYTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMESTPSLSCSNK
CIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLRGVPGVRAERFAEAMRIRH
CALSLVGEPIFYPHINELLSLLHGEHISSFLVCNAQHPDELAALQRVTQLYVSIDASNRE
SLRKIDRPLHRDFWERLQRCLDILREKRNVHRTVYRLTLVKGFNIDDEVEGYADLVEKGL
PCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNEELERRGLSYGLSAEHAHS
CCVLLASKRFLVNGKWHTRINYERFFELLEREKQTGESFAPEDYMRETEEWALWGNGGFD
PNDRRVHTKGKNKGKIGLSEALRRIENWSVELSYRPPEQNKPSKHLTNEQICFKACPPIA
THTRMGSFLAAGWVFQVKYSSTLDQNAEFSSLLH
>A0A328SCY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. SHI613|TrEMBL
MLISETKKKDMEKKGYRFAGNHLHSGNKICHWTRKSIVDDGVCYKEEFYGIKSHRCLQMS
PAIPYCQHKCLFCWRDTEITKTSWDSDDYDDPKTIIEDCIANQKQLLCGFFGNENANPQK
LEECLRPNNAAISLAGEPLLYPEINQLLREFEKQDFTTFLVSNGERPDLLKKLEDEEPTQ
LYLSLDAPNKDVYKKVCLPQVENGWEKLNESLELLSTLDTRKVLRITSVNELNMLNTDEY
AKIIDKTDIDYVEIKAYMFVGDSRNRLKWENMPTTQQLHEFAYDVADKSGLDVINEVEKS
RVLLLGDKLPKKYNN
>A0A3M7MSU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chaetothyriales sp. CBS 135597|TrEMBL
MDSAENSEWLILTADWIDRFLTFWYEHRLLAFAVVVSLSLTTHVLVRRRDAADGVAVPSS
PSSAVEKGVVDVVSDDDNRVGPARTFPAQTSTKARPVKVVNGRRPGKKLTAAISPSLPAD
LKLRPFVFYASLTGTSERLAKHVVAQLRRLGSSSGSQILEPELLDLSYIDLDDYFISGPK
VPSSSSSDSEQAAWPFYAIVIPSYDIDTILNNFLAHLDETHNDFRIDTSPLSTIAGYSVF
GVGDQEGWPTEQQAFCYQAIEVDRWMAKLTGRKRAYPLGMGNTKGDLDKSLDEWINGLTD
AINDIAATGTLGEGVPGSGNAVESEDEAEEAEGADFPDRGRRKRQKTSQSTDLEDVGGAR
KPTAKGRAPLATDWTGAYSSRSTAATAEPAPLKAMVPKESPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPALSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPRLIFEGAKEGHYKKIKMMRGVPGVRSERFQDAMRIRHCALSLVGEPIFYPRINEFV
GLLHGERISSFLVCNAQHPQQLQSLQRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNT
CLDIVREKRFVQRTVYRLTLVKGFNVEDEAEGYAALVAKGLPCFIEVKGVTYCGTSTATG
AGLTMQNVPFYEEVVQFVEALNAALDRRGLEYGIAAEHAHSCCILLASNRFHIGGRWHTV
IDYDRFFNLLEAGKDFAPEDYCKPTPEWALWGNGGFDPRDERVDRKGRKKE
>T0MZ32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon E-plasma|TrEMBL
MANKYAEIYKKQHYALVGEHSAVKVCHWTKSQMTGGASCYKGTFYGINSHQCVQMTPALN
SCTENCSFCWRFQGFDSMKISYEDDPEFILEESIKAHMKLISGLKGNPKVTEEMWKEASM
PKHIAISLTGEPTLYTRLGEFIELAGRRGISTFLVTNGTLPMVLEKLNPLPTQLYVTTAG
PTKEIFNDVLNPAIGNAWENFSRTLELLPSLDTRKVIRHTLVKDVNMPYIDEYERMDRTA
DPDFIESKGYVHVGQSITRLTKDNMPSHDLIVEFSRELASRLGYDFTSERRDSRVTLLCK
DPTNRFINFNEIEEKAITIN
>A0A135TDH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum nymphaeae SA-01|TrEMBL
MASTLEPVGFRSMLNNVHDIWQQVRIPVILFTAFGLLILRFYLHSIEEKSELKALPKAYN
REKPETKPVEETKKKDVKPSPPSPTVESKAPKSNGPKRIKGGIVKRTSSNDAKGEALVRK
VRPLVFFSSITANTPKIAKEYAEGLEKELQKVAAETACSFMTPEVLDLAEVDFDDYFITP
PKSEEDPADLFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDR
EGWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVVDVLGML
AKTGSLGEGLPGSGAPEESDDESAAEDDDEVLIEDSEVKPEKLKSRKNIDDVEDLGRIMK
SSNPDPATNGRAAKSATATAGAAAPIAVDFTTYGKTVAKKTPLNAAKEMVPKNSPTYASL
TKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCW
RHGTNPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSL
VGEPIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKI
DRPLHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVE
IKGVTYCGTSTASNAGLSMSNVPFYWEVQEFVTALEKRLNEKGLKYGIAAEHAHSCCVLL
ASDRFYKDGKWHPRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGKGGFDPRDDR
VDRKGRKIEA
>A0A851MQL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Campylorhamphus procurvoides|TrEMBL
LDVSMDMWNHFHTCVASIWLHRFYIYSAVALGIILWIVIQFTTRTKRKVGEVLLQKGTEA
KLGNGCATPQAKEVYVAGVKIFYGSQTGTAKGFAKTLAEAVAALNLPVQVINMGDYDPDD
CLSEETTSRSICVFLVATYTEGQPPESSAWFCKWLEEAANDFRFGKTHLKGLRYAVFGLG
NSLYVDHYNTVGRRIDRWLWVLGASRVMTRAEGDCNVARSRHGSIEADFGAWQTKFLTRL
QALCRGEKKPCSGRCKKGKCKSPGKQSKESSDHEHGASEHENTEAEELFETSSEEEADAE
EAGGTNSVIDVEDLGNIMGHMKKAKRECELQAGGAGMMRESTGRKEEGEKREMITPALRD
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFKG
>A4H4B8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania braziliensis|TrEMBL
MIIAFLFQLLVSVGLPFVALLLYNHLADSIHARGSVDVDDVNAFSQRVRAELEQLNVPPA
LPEAAPGQAAPPPAPMRSSPAVTAPPPPEAAEILIAYATQSQNSLALAHKLFSLITAQLH
TAPPSTTEDAVCPLVRVMEMREEEDSSASVAAASAAGGRVSRTNVCRVDTLLEQSQYALI
IFIASTYTNGVAPPRSQAFEAMLKDSFEDHRIPRNTLARKRFAVFGLGDIAYGEERFNAF
AKNLHEWCRGLGAPPFVVPPVYTTEAKTQSLFRIFSTALLKWVSRATFHRDGTVTVKKKS
EMGTTGPAAASATGMLSHKAGGITAAPAGETCGSEGASCACQQSTQQQQQRQPCGSGTCP
DGDDNCVCYKTDSIANCVAASKRDDDDDADDDDEEEEVNGENDGMDDVEDLVWDGTEDTD
FDINKDPSELPELLYPKLRQNLEKQGYRLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYNI
NSSQCMEMTPSLACANKCVFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMRG
VPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFCELLHQHHISSFMVTNAQFPEQLRD
LKPVVQLYLSLDAPTPEELKRIDRPLFEDYWERCLSCVKELAKKQQRTVFRLTLVNQYNT
ENVKAYADLVEMGQPDFIEVKGVTYCGTSTSSTLTMKDNVPRHDEVISFCKALCTEMASR
HPHYSTLQMNTEEKGGDDGDDDEVIVIPAEERNRPYHIACEHEHSCCVLIALDKFFFEGH
WHTWIDYERFYHLVESGRTDFTSLDYAAVTPAWATYNSKEKGFDPEQTRVVRKNARPTVV
TASC
>A0A6P6UGS3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coffea arabica|TrEMBL
SRGKIFFISQTSTSKGLAQRLHNLLTLNNLPFDLXDPKDYEPEDLXRETLVLVIASTWEN
GEPPQNGAFLVNWVNESAEDFRVGAALLVKCKFAVFGVGSRAYGRRSMLWAKXLVGNLRK
LGAKELLEICEGDVDGGDLDKVFDGWSQKVVEALTDNXKENGVYFGNLNGVDGEASDEEE
YDDEDDEEGENGRGVGLVDLEDIAGKGPSRRKEMVEAKANGELNGVTGKKAMVTPVIRAN
LEKQGYKVIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGKSWQWKMDDPLEIVNTAIELHTKMIRQMKGVPGVKEGRLSEGLAPRHCALS
LVGEPIMYPEINTLVDELHRRRISTFXVTNAQFPEKIKLLKPVTQLYVSVDAATKDSLKA
IDRPLFGDFWERFVESLKALKDKQQRTVYRLTLVKGWNTEDVDAYSSLFGTGNPDFIEIK
GVTYCGSSATSKLTMENVPWHYDVKEFSEALCQRSNGEYEVACEHVHSCCVXLAKVEKFK
VDGQWYTWIDYEKFHDLVASGKSFTSNDYMAPTPSWAVYGAEEGGFDPEQTRYKKERHHK
NSR
>A0A7J7DL94|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tripterygium wilfordii|TrEMBL
MAVMSHSSFSTRLTLLALLSASTFYFFYKSRRLKLLKHSLNPSPNTSKGKIFFISQTGTS
KALAHRLLNLLHSRNLSFNLIDPKQYEPEDLSKESMVLIVASTWEDGKPPPDAKFFADWL
AESAADFRVGSLLLSMLRFAVFGVGSRAYGEAYNAVAREFSRRLKELGGKEIVGVGEGDV
DRGDLGRVFEEWSTKVVGVLEEGFGVVENRAVLGNGVDENDNESAYGSETDEEEENGRES
EVVDLEDIAGKAPSRKSSATAKTNGRINGKRDMVTPVIRASLEKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDP
LEIVNSAIDQHLKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELH
RRGISTFLVTNAQFPEKIRMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKA
LKEKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVP
WHTDVKAFSEALAIKSEGEYEVACEHVHSCCVLLAKTEKFKVNGQWFTWIDYDKFHDLVA
SGKTFNSNDYMAATPPWAVYGAEAGGFDPDQSRYRKERHHKSSR
>A0A7J7D364|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tripterygium wilfordii|TrEMBL
MAVMSRSSFSTRLTLLALLSASTFYFFYKSRRLKRLKHSLNPSLNTNRGKIFFISQTGTS
KTLAHRLLNLLHSQNLHFDLIDPKQYEPEDLPKETLVLIVASTWEDGKPPPDARFFADWL
AESAADFRVGSLLLSRLRFAVFGVGSRAYGEAYNAVAQEFSRRLKELGGKEMVGVGEGDV
DRGDLDRVFEEWSTKVVGVLEGGRGVVENGAVLGNGVDENDNDSAYGWETDDEEEENGGE
SEVVDLEDIAGKAPSRKSSSMAETNGRINGKRDMVTPVIRTSLEKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDD
PLEIVNSAIDQHLKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDEL
HSRRISTFLVTNAQFPEKIRMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLK
ALKEKQQRTVYRLTLVKGWNTEDIEAYFNLFSIGKPDFVEIKGVTYCGSSATSKLTMENV
PWHSDVKAFSETLAIKSEGEYEVACEHVHSCCVLLAKTAKFKVNGQWFTWIDYDKFHDLV
ASGKTFNSNDYMAATPLWAVYGAEEGGFDPDQSRYRKERHHKSSS
>A0A8C6X0K3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Naja naja|TrEMBL
MDTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQRFALVLTEAVAS
INLPAEIIDMQDYDPDDSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFR
VGKAYLKGLRYAVFGLGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHG
SIEADFEAWKAKLLIRLQALAKGEQKACSGRCKKGQCRSKSKVSQEAKEQETSEHVENEE
EDFFETTSEEESDTENGRGADQVVDVEDLGKVMDQMKKSQKEHQTNGVIPIGVGTQHGRG
EDERREMITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRD
DRFREGMEAKHCALSLVGEPIMYPQINQFLKLLHHHNISSFLVTNAQFPDEIRNLQPVTQ
LYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAY
SDLVSLGKPDFIEIKGVTYCGESSASNLTMANVPWHEEVTHFVQDLADLLPDYEIASEHE
HSNCLLIAHKKFKIEGKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGA
KERGFDPVDTRFQRKNKIKDISGC
>A0A7K8N982|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Casuarius casuarius|TrEMBL
LDVSMDPWNFFCTCLMSLWVHRFYIYSSVAFGISIWICIQFFTSKTRKKVTEHLSLFLTE
DKLVNGYATLKAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLSAEVINMGDYDPD
DSLTEETTSRNICVFVVATYTDGQPTENAAWFCKWLEEAANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSR
LQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDREHGASEYENTEAEEFFETTSEEESNA
EEAGDTNSVIDVEDLGKVMSHMKKAKVLVVQQMHFVNQLLQVKSNSLIYFLFSGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEI
NRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQ
RFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSAS
NLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKIDGEWCTWINYDR
FQELVRDYKRSGGSKTFTAADYMAKTPHWALFGSRERGFDPLDIRYQRKNKTKDISGC
>A0A832ZQ07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrodictium sp|TrEMBL
MGWCEISQFTIRTVRGKSWKLKIDDFPEPYRSLYMLLKKQGYVLVGRHSVVKKCHWTHMA
LTQKRFCYKCKFYGIASHRCVQMSPSALWCWNACLHCWRARPQDIGISWDETKLLWVDDP
EYIAKGSIEAQREILSGYKGHPKIDPRMYEEALNPKHVAISLTGEPVLYPRLGELIEVYH
KMGMTTFLVTRGVRSDVLANLDEEPTQLYISIEAWDKKSYEYFNKPLVPKAWELTLETLQ
LLPSFSCPTVVRITLVRSFNMHEEALKGFAKLMEIAQPTYIEVKAYMYLGYSRNRLKPSD
MPKHEEVLNFAKKLGELIGYKVLSQQIASRVVLLSRLDKPIRVGEGCPGAWKKWSEEWES
EEAEYKLAKENQS
>A0A7K7X472|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mohoua ochrocephala|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAVGISLWIVIQFTTTRTKRKESHGNPASSEG
TADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRLDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNGQGLFLQAKLNCLMIFALFSGYKLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEW
RWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALSLVGEPIMYPQIN
RFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDYWQR
FLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
>I2GZ16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7)|TrEMBL
MDAIGKHNVSVAVGASAIAYCYFGGRTSFALVGVVLYDMFYSNYVFKSSSPTSANFVVEP
EPVEKKKHKCCGGKGGSGCCSNKKDANDKAKKSCKCGHKKNTKESKTVPLSTGFTNKITL
EKSIGDITNSTKDNSFPIAVDFTQSFKPKKTKGKKKDTSKKVIISKLPSKNSSEEDVSAS
QPIAVIDPSTVKSAMTVSTDKLINSQIYIFYSSLQGASLRVANRVKDNLSNKVQDLKYTP
IVIHLDEIDDLDDFFVNLPSSENNQINSLYILVIPSYDTDCPLDYFLQTLQENFYDWRIN
KFPLTKLSGYTVLGLGDKESWPEKFCYQAKKVDHWLSKLGGRRIYPVGEICMKTEGDSKV
DEWSDLLSECLKDDNPIVYQYEQSDDEDSDEENSEAEDEDLQDVEDIVKNGKVINDTDIK
QMVSKNSPTFKQLKKQGYHIVGSHSGVKICRWTKSDLRGTGSCYKQSLFNITSSRCMELT
PSLACSSKCVFCWRHGTNPVSKTWRWEVDEPEYILENALKGHYAMIKQMRGVPGVVAERF
QKAFKVGHCALSLVGEPIMYPYINRFVELLHEKEITSFLVCNAQHPEPLENLGKVTQLYV
SIDAPTKDELRKVDRPLFKDFWERMLQCLDILNTKQHHQRTVFRLTLVKGFNMGDISAYA
DLVQRGSPCFIEVKGATFSGTSKSGSNPLTMQNIPFYEECTNFVKEFAKELQRRGLDYDL
AAEHAHSNCILLAHKKFQINGEWYTHIDFAKFFELLNSGKDFTHMDYMAKTPEWALFGNG
GFAPGNTRVYRKGKNKQKKQDDSSQVDTNMETTIKPGNDITDKMITTNEVKAAV
>A0A8C4NNW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eptatretus burgeri|TrEMBL
STVIHLKDYDPEDGLLEEARNGSLCAFVLPTYTEGNPPDAAAWFCKWLSEAANDFRYGKT
HLSGLRYIVLGLGNSFYEEHYNKVARNVDKWLWHLGARGLMPRGETDKNSSQSRHGSAEA
DFAAWLQQVRRRLGQLISSKDIKVVDPEEHSHCCANKLSKGQGRRKAQKESSGHGSNLRS
EEGSYEYETTSEEDEGDTDGDLESLVDVEDLGIVMKDMPNSKVSLVTECRCKLSPICVFH
LKMLRQDSSYAKSEPTCHSLPPTPHRNLEPVTQLYVSVDASSERSLKRIDRPLFKDFWSR
FLGSLQALSEKGQRTVYRLTLVKAWNVDEIQAYAELVTLGQPDFIEVKGVTYCGEGGANS
LTMANVPWHEEVVSFVTHLADLLPNYEIACEHAHSNCLLLAHTRFKRDGVWWTWIDYDRF
HTLYQEHESTGGLRTFSAEDYAAPTPVWALFGSSGQGFDPVETRHLRRGKPKDISGC
>A0A843KIY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp|TrEMBL
MHSEACKALRKQGYQFVSPASSAAVKPCMWNKRALRGGAMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVVEEEECPPEAIIESLPRLQKKALAGYKVSPYVAPERFAEALR
PTMVAVSLSGEPTCYSQLPNLIDGLNAGGYTTFLVSNGTRPDVLARCRPYQVYISLDAPD
RETYLGLCRPREDYWDCIQESLAGLAGRRSAIRTTVVRGYNDFAPEGYAAIYQDSGARFV
EVKGYMYLGYSRKRLQRDQMPEHSDVRAFAEKIAEHCDYTVKDESPASRVVCLERKI
>A0A1D2QG93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haladaptatus sp. W1|TrEMBL
MSESDTVEETSASNRDASDSDDGPKQVSSPNYHSENHTAAQTCGWTANALRGEGKCYKNI
FYGIESHRCIQMTPVVKCNERCVFCWRDHRGHSYELGDVEWDDPEAVVDASIRLQRKLLS
GFGGNDEVPREIFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTNPE
MLERCDPTQLYVSVDAADRATFDRVVRAVDDDAWEKLIDTMDVLAEKDDTRTVIRTTLVG
RENVANPDWYAAFYERADPDFVELKAYMHVGHSRGRLDRSSMLDHEDVVEFTEQVGEHMP
DHDVLKQVPASRVALLSKTEDTWVPKLKKDSEFWERDSTTWTRLGE
>A0A257AKD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon ex4484_205|TrEMBL
MQRELLLRQGYKLVGKAGGVKLCHWTKESLRGDRYCYKQKFYGIESHRCIQMTPSVFHCN
LNCLFCWRYNNYPYVEMKEWDDPSYLLEKSIEAQRALISGFGGNPKVNKEKFEEAMEPKH
IAISLAGEPTLYPELGEFIEEAHRKGFTTFLVTNGTNPKALEELDPLPTQLYVSVTAPNE
RVFEALNLPRVPRAWESLIETLRLLPSLGTRRVIRHTLVKGWNMPFVEDYVKLDSIAEPD
FIEPKAYMNLGYSRYRLNPGNMPKHWEILKFSEELSKELGYHIVSESKESRVVLISKRKS
GIKIAQ
>A0A7J9FTX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium trilobum|TrEMBL
MTPSSLSXXXXXXXATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKALAQ
RFLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLADIS
TDFRAGNLLLSDCKFAIFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVDGGE
LESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLEDIAG
KGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLRGR
GGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAID
LHTKMIKQTKGVPGEFTRPIVAGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELH
RRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKA
LKEKHQRTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVP
WHSDVRAFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVA
LGRPFDSEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A6VH26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis (strain C7 / ATCC BAA-1331)|TrEMBL
MIPEQIHNILRKQHYQLKDHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLESFESPEWKEPEIVAEDILNMHKTIITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYQKICGGTKENWESILNTLDILDSKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRNRLNLDDMVKQFELLDMGKLLEENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A662NP38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococci archaeon|TrEMBL
MDVKPNMPEEITNLFKKQHYALVGHHSSVKLCHWLKESIKNNRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPRPFDDPAFIVEESVKAQRKLLSGYWGVKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEPEALEKMMKEN
KLPTQLYISLTAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMH
NPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVENLPEYHIE
DEYPPSRVVLMMRDDIRKADRVIKH
>A0A2U9IP39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus sulfidivorans JP7|TrEMBL
MIMVVSSFRIDTLSKIMQEMEKQKYHIVGSHSAYKKCHWTHEALTEGRYCYKGKFYGIES
HRCVQMTPTAAWCWFRCIHCWRLEPEDIGMEWDETKLPITDDPEYIAEKSIEEHKKAVSG
YFGREGVDPNMVKEASKPAHVAISLTGEPTLYERLGELIKEYHKRGLTTFLVTSGIRPDV
LASLEEEPTQLFVSLQAPNEKKHKLINRPIIANSWNLFMKTLEILPSFSSPTVIRMTMIK
GFNMSEEDAKEFAQLIKIAMPTYIEIKAYMHVGPSTLRLSRDAMPRHQEIREFSKIMEKY
TGYKIISEHVPSRIVLLSKLEKPIQIGNAWTNAWNWSTKDTDDDIHGEYKEAELGCTEE
>A0A8C3JHM1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Calidris pygmaea|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYSAVASGISIWIAVQFFTTKTKKKVTEPVRTEDKL
VNGYGTQQAKEVYVAGVKIFYGSQTGTAKKFAAGLAEAVISLNLPVEVISMGDYDPDDCL
AEETTSRSICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRSVDRWLWMLGASRILTRAEGDCNVAQSKHGSIEADFEAWKAKLLSRLQV
LCRGEKKPCGGKCKKGKCKSSRKQSKESSDHEHGASEYENTEAEELFETSSEEETDAEEA
GGANAVVDVEDLGNIMSHMKKRERELEEGDVGTSLMRENTGRKEEGEKREMITPALREAL
TKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVRADRLEEAMAAKHCALSL
VGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTRESLKRI
DRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELIALGKPDFVEVKG
VTYCGESSASNLTMANVPWHEEVVGFVQELADLIPDYEIACEHEHSNCLLLAHKKFKVDG
EWWTWIDYGRFQELVREQERSSGCKTFTAADYMARTPRWALFGSRERGFDPLDVRYQRKN
KARDISGC
>A0A0E0D7K2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza meridionalis|TrEMBL
MPPPFPTATAASSTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPPPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSVPLLLLVLPTHDGGAPPPAA
SFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AIGEGDVDGGDLEAVFDEWCGRVVRVVKGEEIGEGHKGESDGFDELELEEEESDDDDDEE
EVDGGEVDMEDIARKAPAARRQNGKVGGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEI
NVLIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWE
RFLDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATS
KLTMENVPWHSDVKEFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDY
DRFHELVTSGKPFKSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A1Z5SMC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii EXF-2000|TrEMBL
MDIDKILQLPEELLFLWHAHRAEVLLSAGLLFALLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKSAASQEAQVIEKVQPI
IFYYTLGGSTKVYAESVAQDLATSSPSSLLEPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKDESDNMLREWTKGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETAAPRKPKRKSANRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALAKRG
LDYGIGAEHAHSCCILLADRGRFFRVPAAEKDNPAAKRKWHTLIDYPRFFDCLESGKDFA
PEDYVGPPTPEWALWGHGGFDPRDERVDRKGRPKEPKVQEVQEVQEVQK
>V4J7F6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured Acidilobus sp. CIS|TrEMBL
MEVRAEEDVYRLLDQRLIKQGYHLVGRHSSVKKCYWNHAALVEGRFCYKGKFYGIESHRC
IQLSVTNHWCWNACLHCWRLRPQDVGIQWNETRMPFADDPRSIVEGAIREYRRIVSGYKG
RPGVDPKMYQEATNPKHVAISLTGEATLYPMLGELIKEFHRRGITTFLVTRGVRPDVLAN
LEEEPTQIYVSLEAWDKESYDYFNRPLVPRAWELTLETLQMLPSFSSTTVYRITIVKGFN
DNDAALRGFAELVKLGMPDYVEVKAYMYVGASRNRLRLENMPRHEEVKAIARKLSELTGY
PVVSESAPSRVVLLSRLERPIRYGNAPVDWNSPDIPAPGEYEEPNEAATA
>W7FSE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum (isolate 7G8)|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDISNTNDTNN
TNIMNNTNNTNIMNNTNNTNIMNNTNNTNIMNTNNTNIMNNTNNTNIMNYTNNIRTGENC
VSESETSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCR
WTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKA
EIIVEEIIKKHKAMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELH
KRNISTFLVTNAQFPQELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKI
LKNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQN
IPWHEEVYQFAWNLINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFH
QLVKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>L9X826|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronococcus jeotgali DSM 18795|TrEMBL
MSDSADPGSSADGDDAPAQVSSPDYHSENHTAAQTCGWTANALRGEGCCYKKVYYGIESH
RCIQMTPVVKCNERCVFCWRDHRGHAYELGDVEWDDPEAVVDASIRLQKKLLSGFGGNDE
VPREVFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTRPEVLRECDP
TQLYVSVDAAERHTFDRVVKAVEDDAWDRLLETMGVLREKEETRTVLRTTLVDGENMHHP
DWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSSMPDHEEVVAFAERVGEYMPEFTEVKG
VPSSRVALLSKTTDTWVPKLEKDSEFWERDPMTGD
>A0A8C2RS40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capra hircus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTAPKASQD
LMMNGYIFRPKKEVFVSGVKIFYGSQTGTAKGFATVLAEALSSLDLPVAMINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAKWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALCKGERKRCRGNCKKGKCESNQRGSEAAEPGSHTQEELHHGDAEEEEPFGSTSEEESD
TEDHQSQNSVIDVEDLGKIMDHVKKEKREKEPQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTIKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDDXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXRTVYRLTLVKAWNVDDLQAYAELVSLGNPDFIEVKGVTYCGESS
ASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFKIGGEWWTWIDY
SRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXTQTDGCRRFSDSTVIFFPRTGYTNNISHREGREEEHGATSHVPGLRREQP
HWSAWDLA
>A0A075GZ86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_199_D03|TrEMBL
MIFSMSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRNEGSCYK
HKFYGISTHSCMEFSPAGMYCENRCIYCWRPMEFYDSMEMQPQNVAEPEEIMTKLMAERK
KLIMGHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVT
NGQEPDMIQKLQDENALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDT
RTVIRLTLIRGYNDDKEMIPAFTSLLRQSNAHFVEIKSYMHIGRSINRLEYSDMLEMDEV
RSFANKLTQENNTFTVMDESEISRIVILQNKKRFIDRFIPTYC
>A0A0H1BFZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blastomyces silverae|TrEMBL
MAGEDLGIVARGLLALWHRYRAPILLLAAVVFTVVWLAPRNPKRNTPEPDSLPASQNKNQ
NQNAKSELESFSSNDPVAADLPNRDRSRSSSVDNRPKQAKQPANGPKRVRGIKPEKNGAK
HQIGGGALPQDIAIQPLVFYASLTGATETYAKSFCDRLQKATHPLLGNNSKTNLLTPELH
DLSYIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMINNFLGHLDETHNDFRIDTS
ALSGLAGYSVFGFGDREGWPTEEEGFCSQAKEVDRWMAKLTGKKRAYPLGMVDVKGDNTQ
KVLNEWCDGLTDVMFDLMTSGGLGEGVPGSGDPVESDEEGIDDDGEESDENGENRRKKGK
KEQIMDLEDINLGGSNGRKASANAQPLPVDFTTQSRAQASKPASQLEMVPTSSPTYAALT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWR
HGTNPVGTVWRWKVDPPDLVFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLV
GEPIFYPHINEFLALLHNERISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKID
RPLHRDFWERFQRCLDIIREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCFVEV
KGVTFCGTSTSAGAGLTMQNVPFYEEVVTFVAALNAELTRRGLGYGIAAEHKHSCCVLLA
SDRFYVNDRWHTRIDYDKFFTLLDKEKNDGIPFRPEDYMRETEEWALWGNGGFDPKDTRV
YTRGRNKAKLNAALKEAQDASVSAEG
>A0A672IJI3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarias fasciatus|TrEMBL
MVLKKQNLSSEDVSFISKVERNSHQPHKEIEVHVSGVKIFYGSQTGTAKGFAQQLCQEVK
ALGLPAEVIDMKDYDPDDQLADECVSKTVCVFLVATYTDGRPTENAEWFCKWLEEASTDF
RYGKTYLEGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSAVRIMTRGEGDCNVVKSRS
GSVQADFLSWKVRFLSRLQALVKGEKKSCSGNCKTGGSCKNKKRDEEQQQEEEEEEEEEE
EASLQNHSSEVRTEFTVFRIRTELFTLKRMEDEGERREMITPALRNALTKQGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKMDPAHKILEDAVEKHQGMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINA
FIRLLHQQHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRF
LASLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASTL
TMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYQRFQ
ELVEAHEESGGQRSFSASDYMAKTPSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A0G4IAT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chromera velia CCMP2878|TrEMBL
MFRYLDPRLHATLRERQVQGDGCGDGSVELPLVTVIYASYTGNTKTEAESLGRFLEASGV
CKVDVLNLSDLQFDIDLPSKRFVVFLVSTYEGGEPVPSCKQFFVDLGEAVFDFRYDKTFL
QKLSFAVVGFGSIEYQSNFCRCAGELDSWLASLSARRVVPLLKVTDTDSIEGQMRGWRAA
FVNALEGMKGSGLKQVETEEVGCCGGGGGKDQVGNSCGCASSLSPSGLDKSGATETVGVE
KGDALSDGSSSASESDYDDEEDGDGDGSFVDVEDLRGREEEGEGGDGQIRVKEKPAMVTE
RHRQQLTKEGYKLIGSHSAVKLCRWTKHHLRGRGGCYKHSFYGIASLSCMEATPSLACAN
KCVFCWRHHKNPVGREWRWQMDPADQIVREALDKHAAMIKMLKGVPGVTPERFEAAQKVK
HCALSLVGEPIMYPQINELISELHKEQISSFLVTNAQFPEAIENLRPVTQLYVSVDAPTA
ESLKAVDRPLFSDFWERFVRCLRALKEKRQRTVYRLTLVKQYNMSENGEDAEELRRYASL
VKEGYPDLIEVKAVTFCGTSKGSDLTMKNVPWHEEVLNFCNSLVSIDADLQSEYEVACEH
KHSCCVLIAKKTFKKEGQWHTWIDYDRFHSLVASGKPFSAEDYCAPTPSWAVIGSEERGF
DPQDSRVYKNKAKQEKSRLLEATDLEEKLQIRK
>A0A1F7WLE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon RBG_13_36_6|TrEMBL
MQKWYQDLKQKLKKQHYGIVGNHSAVKLCGWTKKSLLNQGFCYKQKFYGIRSHLCCQMTP
SVGFCQNNCIYCWREVEYSIANQFKVVDDPKLIFDESIKAQKRLMSGFGGTRRTNMKKLR
EAQNPMHYAISLSGEPTMYPRLSELIKLLKKNDKTTFLVSNGMLPEVIANLEMPTQLYIS
VDAPDEKHFKKISKPLYKDSWQRLNKTLDVLKKLRKKTRTTLRLTMIKEINMLQPDKYAE
LIEKANPKFVEIKAYMFVGTSRQRMTLANMPYHKDIVDFAQQIEANSDYKFIDEKEESRV
VLMMKKDTKDRVMEFD
>A0A6A4KDJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apolygus lucorum|TrEMBL
MTFGAQVEDVPAYYKKQHFCNVYTEWIEPQIKDNKRQRLQSLHRNIDNRFRCIEVYFATE
YGNTKKLCEKLVAYCTSTISIDSVLIDLSTVDPEDVLHTKNLPVGRCLSLFVLPTVTNGQ
PPETAKWFYKWLSDAATDFRIDKQSYAHVSYAVFGLGNSAYAENFNVVAKEVDENLSQLG
AHRVCKLMLGDEDTCESKNGGLEADFDAWTAIVKNVVRSTTTTSNEVDNTRENGIETSSE
EEDVVDIEDLVKPKSKQTNYASKDAKEMITPQLRGVLTKQGYKLIGSHSGVKLCRWTKSM
MRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWKWKMDDANTILN
GALDNHYNMIKEFKGVPGVLPEKFAEALAVKHCALSLVGEPIMYPEINKFCRLLHDEGIS
TFLVTNAQFPDAIRSMDPVTQLYVSVDASTKESLKKIDRPLFKDFWDRFIDSLKALSEKG
QRTVYRLTLVKAWNIDEMQNYASLVALGKPDFIEVKGVTYCGGDSSKPNSLTMANVPWHE
EVTSFVEQLVDLLPDYALASEHEHSNCLLIAHKKFFMNGKWRTWIDYAKFHVLMRKHYET
NGECSFSAMDYAAETPSWATYGSMERGFDPSERRWHRKSGTKDISGWSRRWFVENFYWTE
QPPVPNSPWDGLLDAGALSPPCNQIFEVGPLAPLLIGQEDCLYLNVYSPVIPVNGRGIDL
LPVLIYIHFGGFMFGSSIFHGPRYLLDYDMVVVTFNYRLNVIGFLSTDTPELPGNVGLLD
QVLVMRWVQKNIMSFGGNPNDVTIAGTSAGAVSVHFHMLSPSSQGLFHRAILQSGAAIQN
TALQKQPRQKFYFLADYFNCVRNSTEYIIECLQQVPANELVQSMTVLQKFFFQPILVFGP
TVQMDQPQAFLPDLPYELMRNGIIANVPTLFSCITNEALFPIAAFANNDSALSYLDQHWN
EVAPYLLDYLWSIDIRNANKTSQAIRNFYFGDKPISRDTIFDLITMGNDRLYLDDIFQSV
RWAVHYISSPVYFYRFGYRGARSITNFLSGTNINWGASHADDSFYILNSTLVNTETTARD
RRMISIMVGIWGSFITRGVPVTGDGIPLTPVQKQNALKGPLNYLWIDSPSYIVPNSSYDF
GHTQFFNSLPIDEPFFGRPANIL
>A0A4X1SWG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQGFAAILAEAVTSLDLP
VAVVDLKAYDPDDYLLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKT
YLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEA
DFTAWKAKFISRLQALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEE
EELLGSTSEEESGSEDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNE
ANEPRAMITPALREALTKQVHAPRERRLLTYILWHESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGE
PIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTY
CGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKIGREWW
TWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPQWALFGASERGFDPKDTRYQRKNKAK
DISGC
>A0A662SSX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MQEYPKRMLEKQGYKIVLNHSAIKPCYWFREAIMKGRTCYKHKFYGIPTWRCLQMTPTAS
FCNSQCIYCWRLNASDVPPRFRWKEVPDPDEEWDDPEEIAEESIRLHRLLVQGYKGVKVF
DREWLYEAEIPAHAAISLTGEPTLYPYLGELVAAYKKRRMTTFIVTNGTLPERLENLSTE
PSQLYITVPAWEENLYKRVTRPLWPDAWQRLLKSLDLLQSFSCPTVMRITLVKGLNMSNP
EGYAKLVNKYNPTYVEPKSYTYVGYSRRRLPRDASPSHAEIKEFAERLADKTGYKILSEA
PESGIVLLSWLDKPIRLSPVR
>A0A497J130|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MQEYPKRMLEKQGYKIVLNHSAIKPCYWFREAIMKGRTCYKHKFYGIPTWRCLQMTPTAS
FCNSQCIYCWRLNASDVPPRFRWKEVPDPDEEWDDPEEIAEESIRLHRLLVQGYKGVKVF
DREWLYEAEIPAHAAISLTGEPTLYPYLGELVAAYKKRRMTTFIVTNGTLPERLENLSTE
PSQLYITVPAWEENLYKRVTRPLWPDAWQRLLKSLDLLQSFSCPTVMRITLVKGLNMSNP
EGYAKLVNKYNPTYVEPKSYTYVGYSRRRLPRDASPSHAEIKEFAERLADKTGYKILSEA
PESGIVLLSRLDKPIRLSPVR
>A0A8J8EFW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 21S7|TrEMBL
MALTFVSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKKNRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPSQLYVSLTAPDVETYNRVNVPMIPDGWDRIKTFLEMMNGLPTRTVVRLTLVKDE
NMHNPEGYAKLIKKANPMFVEAKAYMFVGYSRNRLTINNMPRHEEIKAFAEEIVKHLPGY
HIEDEYEPSRVVLIMRDDVDPRGSGVDGRFIKH
>A0A7J3IJL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPDSLIEVLKKQRYHIVGRHSAVKRCKWLYEAIVHGRSCYKQKFYGIKSHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETKLPTWDSPEEIVEGCIKAQLAILSGYKGNPKAD
PQKLREALRPRHAAISLTGEPTLYEPIGELIHAFHKRGFTTFLVSNGTMPSALAKLSHEP
SQLYVSVCAPNKETYRKVCRPLIPDAWEKLNETLELLHSFKCPTVIRITAVRGLNMENIE
EYAKLIEKANPTYVEPKAFMHVGFSRLRLGYEGMPSHKEIREFALKLAEATGYKVIDESE
DSRVVLLSRLEKPLRFSHG
>A0A2U0RX87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLQHQKYHLVGNHSAVKRCRWLYNSIVQDRTCYKQKFYGIKSHQCLQMTPSVFHCTLGCV
FCWRAQSGDHNIRWDETRLPDWDDPEEIIDGCIKEQKRILTGYKATPNADQNKRLEALTP
KHAAISLTGEPTMYPYLDGLIRGFHRRGLTTFLVTNGTVPEALSNLSEEPTQLYVSVSAF
DKNAFSKICRPHVGGAWENLNKTLELLPSFKCPTVIRFTLARHLNLEFPKLFAELVRKAN
PTYLEPKAYMHVGFSRLRLEFSNMPTHNEIKDFGVQLSSELGYSMLDESPDSRVVLLSRL
EKAIKLA
>A0A7J2LT22|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPEYQRILYRQGYRIVGRHLHSAVKICQWTKESLRNNRVCYKELWYPPVESHRCMMMTPY
LGCNLHCLHCWRLHSGDRPGLVWKEFPLETEELDEPAEIIDEAIEQRKQLLSGWKGNPKV
DREKFEEALKPTMMTMSLTGEPTLYPRLSEMVEEAEKRGMITFLVTNGTVPDALENMDRL
PFQLYVSILSTNRKDYIRLARPLIRDAWERLNRTLKLLPSLDTRRVLRLTMIKGYNMNDH
EGYAKIVEKAQPDFVEVKAYEWVGESRRRLPRESMPYMSDIEEFANKLSSLTGYEIKGKY
KPSGAVLLVK
>A0A497EU14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MEALKKIIDTYKKQGYHFVGKYSLIKPCHWLKASLLSRGTRYCYKQKFYGIPSHRCLQMS
PTIACTQQCLYCWRIQASDLKVTWNEVDLRDYDDPDKVVVNSIIKQRQVLSGLKGNKKVD
RKMLEEAFRPIHAAISLVGEPTLYPKIDELIGSFFKHGFKTVFLVTNGTRPDVLSKMQNE
PSQLYVSLSAPNEEIYRKLCRPRIKDGWKKLMETLELLKSFSCPTVIRITLVKNINMQSI
GEYAKIISKAEPTYVEPKAAMSLGWFRYRLPLNAMPKYNEVEKFGIELAKLIGYNVIDYS
INSRIVLLSKLDKPIKLL
>A0A3R7AIJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSSIEKIYLKQGYRLLGKNKHSAVKVCRWTKESLRSNRVCYKELWYPPVESHRCLQMTPY
IGCNHHCLYCWRIHSGDRPGLSWREFPLELKSFDEPREIVEDAIEKRKELLSGFKGNPKV
DRRKFEESLKPTMMTMSLTGEPTLYPRLSELIVEAEKKGMITFLVTNGTMPEVLEEMSPL
PFQLYVSVSAPDVKTYIKVSRPLIKDGWERLNRTLELLPSLETRKVIRLTVIKGWNTRNY
EGYAKLIRKAEPSFIEVKAYEWVGESQRRLPKDAMPYMEDVRRFAEIISELTGYQVKGEY
EPSGAVLLA
>A0A2I3GUL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nomascus leucogenys|TrEMBL
MKLSVCVILNLDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGFATV
LAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNLCVFLVATYTDGRPTESAEWFCKWLE
EASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCD
VVKSKHGSIEADFRAWTTKFISQLQALQKGERKKSCGGHCKKGKCDSHQHGSEEREEGSH
EQDELYHRDTEEEEPFESSSEEEFGDEDHQSLNSIVDVEDLGKIMDHVKKEKRETEQQEE
KSGLFRNMGRNEDGERRAMITPALREALTKQVDAPRERRFHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSL
VGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCGESSASSLTMAHVPWHEEVVQFVQIACEHEHSNCLLIAHRKFKIGGEWWTWIDYNR
FQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQRKNKSKAISGC
>A0A8H7R899|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor plumbeus|TrEMBL
MSNFMNSLLYGFTNILSVGPEQPREGEEKENEGCSGSNGEGCCKDKPIEQPTKEKSGCCQ
GDNAGDACCSSSTTVIESAAPNKKDGCCQSTPGKSSCACESTTNEPVIIDNLKIIFSTLT
GTAKTMATEIQTKIQANDRVTVHKIEIMDITEYDNDNLLQETAVCVFILSTYNVEGPLDW
FSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGEEFNVAAANIDKWLGRLGATRIYPL
GECDKNADQKGQFDIWSNGFTSELEDKHSLEFSPTNIAFQSDDEDDEDSAEEEEAQPDID
IDGSGSGDEMVDLEDMGNMASKIKAAKAKRAEEEEEFENSKAKAKRLIGTDVGNKPKTAP
QAREMVSPMILKNLTKQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMET
TPSLACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQFKGVPGVKAER
FQEAFTIRHCALSLVGEPIFYPHINEFVTKLHENNISSFLVTNAQFPDKIAEMVPVTQLY
VSVDAATKESLKKIDRPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAEIDGYVE
LIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRKLVSKLDGDYEISAEHAH
SCSLLIAHKDFKVNGEWHTHIDYTKFFELVKSGKPFNSLDYMAKTPEWALHGHEAAGFDP
NETRHYRKNRKTVVPPVIPGITPV
>A0A8I3MXD6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus familiaris|TrEMBL
MTNGCISLQNKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKEYDPDDQ
LVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGKTYLKGMRYAVFGLGN
SVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTKFLARLQ
ALQKGEKKPCDGNCKRGQCESSVEEEPSESTSEEESGTEDHQNLNSVVDVEDLGKIMNCV
KKEKREKEEQEEKSSLVRNTVKNEDSERRTMITPALREALTKQGYQLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEM
ILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCALSLVGEPIMYPEINRFLKLLHEC
KISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNSLKALA
AKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWH
EEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKIGREWWTWIDYNRFQELVQGYED
SGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A850SL72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaera sp|TrEMBL
MSCSDEYASHVAGDLIQITPQVQSKLKKAKYGVYNHSAVELCHWTKKSFANEGSCYKHKF
YGISTHRCMEMTPAAMNCENRCIYCWRPAEFYDTLEMPAELVDEPDVIVEQLLKERKKLI
NGFYGSAKNDKVKLDESLLPAHYAISLSGEPTMYPKLPQLIRYLKTLKATKSIFLVTNGQ
EPAMLRRLVDEDALPTQIYLSTNASNKKMFHAINRPLHADAWERWWESLRFLSTVDTRTV
LRMTLIRGHNDGSGFVGEFAQMMAEGNPHFIELKSYMHVGMSTERLERGDMLEMYEVRDY
AKKLCAAMPSFNVMDESEISRIVVLQNGRRRVDRWINAYLEV
>A0A091V1E7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nipponia nippon|TrEMBL
LDVSMDIWNCCYTCIVSLWLRRFYIYCAVAFGISIWIIIWFTTTKTKKKGEKSNGKPPPS
EGIEDKLLNTSATLQAKEVYVAGVKIFYGSQTGTAKRFAEGLAKAVISLNLPVEVVGMGD
YDPDDCLAEETTSKNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYA
VFGLGDSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSPEKQSKESSDHEREASEYENTEAEELFETSSEE
EVVDAEEAGGTNSVIDVEDLGNIMSHMKKAKREHELEEGGVGTSLTQESTGRKEEGGKRE
MITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSL
ACANKCVFCWRHHTNPVGTEWRWKMDQPERILQEAIENHQNMIKQFKGVSGVKADRFEEA
MTAKHCALSLVGEPIMYPEINRFVKLLHQCSISSFLVTNAQFPDEIRNLEPVTQLYVSVD
ASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISL
GKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLL
IAHKKVRL
>V5AVD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi Dm28c|TrEMBL
MTESISEALWWVLLGALIPLVTLTLTTLLDRWVSRRRKRQMEVARAQAAKEGKTTWMEPN
VHNSTGKTNGNGSTIHDAVKGSKGRVDVKKILIAYATQSNTACKLAHKLFSTLSTTLHES
RDEMQGGSSSCVCSEGSSSCCATSHTARHLPELKVLQLTEEGRQCGVEHLLESQAYGLVI
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKFAIFGLGDIAYGEKHFNRFA
KNLYMWCKGLGATFVVPPVYASEANTIPLFNVFTASLVKWVGRVTFTADGVTILKRQQKQ
LKEKKEKGQIKLCNDVELQGNATYNSEEDEEEEEREEEDEETGRKKRNHNSEGDVEDVVT
DDEDEGEDVNGQSGSVDHAVQALSSEPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTK
AMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRTFRWKVDPPQLL
LAEGIAGHQKMMKQMRGVPGVTPERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHEQG
ISSFMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRR
KPQRTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLTMKENVPRH
EEVVRFCAALCEALACDTAPRDKRTWLGTEPKTGPLQRDPNFDEKRTSVNNMENNSSRCN
RKDEEEGVGINFSGPYSIACEHEHSCCVLIALRRFLVNGVWHTWIDYEKFNALARSGRTD
FTAAEYAAPTPSWAVFRSNEKGFDPTQVRVYRKSGNTTVVTSGC
>G3S3A8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gorilla gorilla gorilla|TrEMBL
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDTKGEEPFESSSEEEF
GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQLMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQNMIKQFKGVPGVKAECFEEGMTVKHCALSLVGEPVMYPEINRFL
KLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLKALAVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLV
AHRK
>A0A534KH74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MRSAVDSEKREVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMT
PAVDACNLACQFCWRTQEWGSDSLLVADDPSFIVDESIRGQRELLSGFKGNPNVSPERFL
EAWHPTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQ
LYVTVAAPNEGIYRKLVAAKSDHEWKKLRETLALLPTLPTRTVIRHTLVEGWNLGWEDEY
AELDRIGRPMFIECKGYSFVGESRLRLEANNVPSHASIRRFAEDLADRIGYQVAAEREDS
RVVLLTTDGQLHPILH
>A0A2D9Q3F3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MAGMDPXLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVASHNCMQMSP
VVDQCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDA
QNPKHVAISLNGEPTLYTRLAXYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSV
DAPNKQVFDEVCRPKWNSGAWEQFEKTIDLLPSLDTRIVCRHTLMXGVNMSDTHIKEFAX
LDNRADPDFIENKGYVFVGHSRENLAMENMPTHDDIMDFSRKIAPLTNRDVLSDSRPSRV
ALVGTEITPIPIPEPTMFFPEDLGIAPPVKHLPVIS
>A0A7J2STI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MGTPIDWAEVRRKREEFWNSSPVYKAIYERMKKQGYHFIGTIGVVKRCHWTKEAIINKRF
CYKCLWYGIESHRCVQMSPVAAWCWLRCQHCWRIQPEDIGMHWDETRVPLVDDPEVIAEE
SIRVHRQIVAGFKGNPKADQKMVEEAMNPKHVAISLTGEPTLYPRLGELIQEYHKRGLTT
FLVTHGVRPDILSNLEEEPSQLYLSLEAWNKEKFMYFNRPVVPRAWELVMDTIDLFPSFK
CPTVYRLTIIRGFNDNEEALKGFAKLIERGNPTYVEVKAYMYVGYSRSRLKPYNMPSHEE
IREYAKKLSELTGYMVLSESIPSRIVLLSRIEEPIRHGKGCPDGVKHPEKYAWVITHEYE
EATG
>A0A534LTR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDAEKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLACQFCWRTQEWGSDSLLLADDPAMIVEDSIRAQRELLSGFKGNPNVSGERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDEFQRRRMSTFLVTNGTTPAALRRLHSEGRLPTQLYVT
VAAPNEAIYRKLVVPKSGHEWEKLKETLALLPTLPTRTVIRHTLVEGWNLGWEDEYAELD
RRAKPMFIECKGYSFVGESRLRLEADNVPTHASIRSFAEGLGERLDYKIAAEREDSRVVL
LTQDGELHPLSR
>A0A7C4F501|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDAGFANLLKRQGYAIVGEHSAVKLCHWMRQKLFYGRVCYKEAFYGISTHRCLQMTPAVY
SCTQMCVFCWRNQQFTTQKIEKPDEPEAIVEQAITAQRRLITGFKGDARCNLELWKEAQH
PNQVAISLAGEPTIYPYLSDLIEIFKKKGFTTFLVSNGTLPEAIRNLDCLPTQLYVTVAA
PNEDVYRKVCLPLHKENWLNLLNTLELFPSLDCRKVIRHTLVKNWNLGWAQDYAKLDMIA
MPDFIEAKAYVFVGGSRHRLSIDCMPSHEEILAFANALAHKTNYPVVSEKRDSRVALLSS
GKKEQKIQNL
>A0A2E5ZY64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPKIASRLSKQKYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLHKIDDDPYELYLESVRAQRRLLTGFGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEVFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKHESLGHHEDYARLDNLA
DPDFIEAKGYVYVGNSRNNLTIENMPSHDDVMGFSQRLAPLVGREILSERRESRVALIGK
EMIPITLPEKVRELPADLGIAKPQNLVLPQA
>A0A2E5IC65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLAKQRYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNRIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLERTLEILPSLDTRTVCRHTLIKGESMGHVEDYARLDRLA
DPDFIEAKGYVFVGNSRNNLSIENMPSHDEVMDFSRDLAPLVXREVLSERRESRVALIGK
EMVPVELPKKIRXLPKDLGIAKPQKLSLPTV
>A0A0B4F9U6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium anisopliae (strain ARSEF 549)|TrEMBL
MSAVCERPDPLQGVFGGLPGAKFDGQKDIVELWHGHRTPIIICALVVLVVIRIYIHKIEE
AEPLRALPKQFEKRIEPLSANKLPSAVNSEKPIAKPNGPRRIKGGITKKPATEETKEYDK
SRPIKTMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFF
VSPAKTVEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFG
DKEGWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVQEVIA
HVASSGTLGEGAPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRM
LRTSDGNGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFY
PHINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRD
FWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYC
GTSTSSNAGLSMSNVPFYWEVCEFVKALEERLKAKGLKYGIAAEHAHSCCILLASERFLV
NGKWHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRK
IENVVVREAPPPDSW
>A0A161HMT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sugiyamaella lignohabitans|TrEMBL
MVGEILELWHSYRVYLLALVVIIAVLFRRTEKNNNQTDEKPSVPARAPSPATREKDVGLK
PTAAPIPVDFTQLYSKSGSSTSSDEESSTKASPKKIRRVPKKFTGGVTAAIASGKAVPTA
LLPSVESKIIVFFSTLTGSSERYAQKVHKRICQISQNTVNPPELVNLDYVEDLDPYFVSP
KEKYAGTIYLLIVPSYETESPLDFFIESLKETYGDFRIDSRPLNPLAGFSVFGLGDKEGW
PEESKFCYQARQVDKLLGKLGARRVFPLGTGCIKTDGEANLNEWLDHLENTLNDPSPPED
IDIADSDDEEETDEIDESVVDVEDMGKIIKKSKEDIAACSPEDDPTTTTKQMVAKDSPTY
KSLTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCMEATPSLSCSNKCV
FCWRHGTNPVGTTWRWQVDAPDVILKGALEGHYKKIKQLKGVPGVVASRFAEAFTVRHCA
LSLVGEPIFYPHINEFVGMLHERHISSFLVCNAQHPAELAALKRVTQLYVSIDASNKESL
KKVDRPLHRDFWERMEKCLDILREKKLQRTVFRLTLVKDFNIDEHEGYADLVVRGEPCFI
EVKGVTYCGTSKSNPLTMQNVPFYEEVKAFVENLNASLAARGLEYDIAAEHAHSCCILIA
QKRFKIDGVWHTAINYDKFFSLLESGDETFTPMDYIAPTPQWAQYGSDEGGFNPDDTRFS
RKKPVV
>A0A8C4ETR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
MPNLFVLISLFVCRVSTSDSKVSQNAHSPSESYLMSVWSNRLYLYSAAALVFGIWLSLKM
ALKKKSFPKDVGTLVYKAVKKDDRDAVVHVSGVKIFYGSQTGTAKAFAKELSEEVKASGI
PAEVIDMKDYDPDDQLADECTNKAVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGK
TYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQ
ADFLAWKVKFLNRLQALAKGEKKTCSGNCKTGGSCKNKRKEGHEQEEEEEEEAQQNNSSE
EDLMESSSDEEESGLQDEKKSGSVVDMEDLGNIMSSVKKAKSKQEGGGDGHMVKLSKMNG
LKKTEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAETILQDALEKHQNMIRQFRG
VPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKSWNV
EEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLTDMLPQYE
IACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPS
WALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A0E0GUF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Indian wild rice|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A0E0GUF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza nivara|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A7E6DCS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MGPSLDSWDFSPLISLWINRFYIYLGFAFAISLWICFQIAIRKQFIFKDKNSQKKSVPKA
TRDLMTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPVAIINLKDYD
PDDNLVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEAASDFRFGKTYLKGMKYAVF
GLGNSVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEADFRAWKTKFV
FQLQVLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEEEEPCESSSGE
ESGTEDHQSLTSVVDVEDLGKIMSHVKKEKREKEQQEEKTGLFRNTVKKEAGERRAMITP
ALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGVKEERFKEGMTVK
HCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLTPVTQLYVSVDASTR
DSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPD
FIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLIAHK
KFKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPWALFGANERGFDPKDR
RYQRKNKSKDISGC
>A0A7N9DB21|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca fascicularis|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEREKEQQEEKSGLF
RNMGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFK
GVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIR
NLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWN
VDELQAYAQLVFLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDY
EIACEHEHSNCLLIAHKKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTP
HWALFGANERGFDPKDTRHQRKNKSKAISGC
>A0A7C2ZB01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldivirga sp|TrEMBL
MRYHEFADGRIVISRDALATLKKAHYGVYGHATVELCHWTKSALTGGPSCYKVKFYGAPV
GGSHRCVEMGPVGMMCSNKCVYCWRPSESFDPYEPGYGEVMSPEEIINGVLKERRRLLSG
YFGHSRSSRGKVLEALQPTHWAISLSGEPTMYPRLPELIKAIKALPNTKSVFLVTNGLYP
EMIERLWREDALPTQLYLSLNAPNRELFYKIANPVIHRDDAWERVLRSLELLSKIPTRTV
VRITLIRGWNTMEDLIPQFAEVLGIGNPHFIEPKSYMNLGHSVYKLTKDNMLRHSEVREW
SMILLKALRDKGMDYVFMDEDPNSRITVLQNMKRYVDRWIEKPTNP
>A0A8B9IPP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anser cygnoid|TrEMBL
MASGGKRKGRGRGAGAAAAWGRRAEAAALRKCFLPFLGTEPALDLDVSMDMWNFSYTCLA
SLWLHRFYIYSVIALGISLWIVVQLFTTKKKGEKSNGNLFSEVVEEKQANGYAALQAKEV
YVAGIKIFYGSQTGTAKRFAKGLAEAVTSLNLPVEVISLGDYDPDDCLAEETTSRNICVF
LVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVGRN
IDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLNCLQALCRGERKPCSGK
CKKGKCKSQGKQSKESSDHEHGASEYENAEAEELVETSSEEEADAEEVGGTNSVIDVEDL
GNVMSHMKKAKRERELEEGVVGTSLSGETAGRKEAGEKREMITAALRDALTKQGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEI
NRFLKLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQ
RFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKPDFIEVKGVTYCGESSAS
SLTMANVPWHEEVVRFVQELAELIPDYEIACEHEHSNCLLIAHKKFKVDGEWCTWINYER
FQELVREHERSGGSKTFTAADYTARTPRWALFGSSQRGFDPLDVRYQRKNKAKDISGC
>H1YX23|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoplanus limicola DSM 2279|TrEMBL
MQSEACRSLIKQGYQFFSKKSSAALKPCMWNRRALSGGDMCYKHQFYGIDSHRCVQMTPT
LKCNQRCLFCWRSMEHEIVEEEECPPEVIVGGIKKLQKKSLAGYNPIVESSTATPRMWEE
ALNPNMVAISLSGEPTCYSRLPELIDILNAGGNTTFLVSNGTRPWMIEKCSPYQTYISLD
APERETYLKICRPVEDYWDNINESLSLLGGRRSAVRTTVVLGINDHTPEGYAKMYQDSGA
DFIEVKGYMHLGFSMKRLVRDAMPEHSQVRAFAEEIAKYCDYNIHDESPVSRVVCMTRE
>A0A6P6HTU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puma concolor|TrEMBL
MAAPSSPGSGYTDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIF
KGKNSKDKSVPKATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSL
GLPVAVINLQEYDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRF
GKTYLKGMRYAVFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGS
IEADFRVWKTKFISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQN
LNSVVDVEDLGKIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQ
GYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGE
PIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRP
LFKDFWQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTY
CGESSASSLTMANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWW
TWIDYNRFQELVQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSK
DISGC
>A0A6J3GSX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapajus apella|TrEMBL
MDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQDLMTN
GFVSLHNKDIFVSGVKIFYGSQTGTAKGFATVLAETVVSLDLPVAIINLKEYDPDDCLIE
EVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLGNSVY
ASHFNKVGKNVDKWLWMLGARRVVSRGEGDCDVVKSKHGSIEADFRAWKTMFISQLQALQ
KGERKKSCGGHCKKGKCESHQHGSEEREEGSEEQDELHHRDTEEEEPCEGSSEEEFGGED
QQSINSIVDVEDLGKIMDHMKKQKREKEQQEEKTSLFGNTGRNEDGERRAMITPALREAL
TKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVKHCALSL
VGEPIMYPEINSFLKLLHQRQISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKI
DRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKG
VTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKFKVGS
EWWTWIDYNRFQELVQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRHQRKN
KSKAISGC
>A0A0X3BLU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus bourgensis|TrEMBL
MHSEACKALRRQGYQFVSPSSSAAVKPCMWNKRALRGGEMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVVEEEECPPAEIIGNLRRLQKRALSGYKVSPYVTPERFAEALD
PTMVAVSLSGEPTCYSHLPELIDGLNAEGYTTFLVSNGTRPDVLARCRPYQVYVSLDAPD
RETYLGLCRPREDYWDLVQESLAGLAGRRSAIRTTVVRGYNDFAPERYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRDQMPEHRDVRAFAAKIADHCDYFIKDESPVSRVVCLERNV
>A0A7L1WVJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Certhia brachydactyla|TrEMBL
LDVSMDTWSYFHTCLMSMWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKGAKSHGNPSSP
EGTEYKLGNGCASPQALEAHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGD
CDPEDGLAEETSSRNICVFLVATYIDGQPPESAAWFCKWLEEAANDFRVGKGFLQGLRYA
VFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLTRLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELSETSSEE
EAGSTESVIDVEDLGNIMGHMKKAKREQELQEGAAGAGRKEEAERREMITPALREALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEVILQEALEKHQNMIRQFRG
>A0A851AP88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sula dactylatra|TrEMBL
LDVSMDTWNLFYACLVSLWLHRFYIYSAVAFGISIWIVIQFSTTKTKKKGEESSGKPAAA
EGIEDKLVNGYATQQAKEVHVSGVKIFYGSQTGTAKRFAKGLAEAVIPLNLPVEVISMGD
YDPDDCLAEETSSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMSRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSSGKQNKESSEHEHGASEYENTEAEELFETSSEE
EADAEEAGGANSVVDVEDLGNIMSHMKKAKRERELEEGDVGTSLTRENAGRKEEGEKREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFAEAM
TAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLITLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLI
AHKKFKIDGEWYTWINYDRFQELVQEHERSGRSKAFTAADYTARTPRWALFGSRERGFDP
FDVRYQRKNKARDISGC
>A0A7G2D693|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus camini|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
GEDKLPSQLYVSLTAPDIGTYNRVNVPMIPDGWEKIKETLGLMNDAQTRTVVRLTLVRGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPHGTGIGGRFIKH
>A0A484NNN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuscuta campestris|TrEMBL
MPPSLSALSTRLAVLSLLSATTIYFFYKSRPHIRHLRNRLKALTELPARNPNHSSRGKIF
FLSETGTSRALAHRLHSFLALSDLPFDLIDPKDYEPEDLHKESLFLIVASTWEGGKPPSN
GGYLGDWLTESSDDFRVGALLLCNCKFSIFGVGSTSYGETFNAVAKDFSKRMRKLGAAEV
MEVCEGDVDEGNLDYVFDDWCKRLAIILKGDSRPYFSNNGNVEESDGEVSEHDDYDSEVE
ENVEDKGIVDIEDIAGKAMAGTRAKNGMVNGETLKEEKEMVSPVIRASLEKQGYKIIGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
RWKMDDPLEIVQTAIELHTKMIKQMKGVPGVKSDRLAEGLSPRHCALSLVGEPIMYPEIN
SLVDELHRMRISTFLVTNAQFPERIMMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWER
FLDSLKALKEKQQRTVYRLTLVKGWNTEDVDAYSNLFSIGNPDFIEIKGVTYCGSSATSK
LTMENVPWHSDVKEFSEALAKKSNREYEVACEHVHSCCVLLAKVDKFKINGQWFTWIDYD
KFHDLVASGRPFSSGDYMAPTPSWAVYGAEEGGFDPDQSRFKKERHHNRSAPS
>A0A484F5M1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanimicrococcus blatticola|TrEMBL
MDETNANNIKKKTESPSDERIRFSYSLEDISMDELMARQGYAKAGAHSAVKTCAWLKNSM
NGTGVCYKSSFYGVTSHRCLQMTPTLMCNQECIFCWRPTEVQAVSPGEWDLPDKIVEESI
QAQRKLITGFGGSPNAVPGHYDEARNPSNVAISLSGEPTFYPYLPELITAYESKGMTVFL
VTNGTQPEMLRKIRPTQLYMSLDASTPELYNEVCRPKSPHLWEKVVESLDVLKEKKAQGV
RTAIRITAVKGLNMADETGFAALIQKAEPDFIEVKSYMHVGFSRLRLTRANMAEQNEILE
FARKIGDLAGYQYAGESEPSRVVVLTKNGELSNV
>A0A7J3DMC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MLDEWKLARLYRAQYRAVGHHSAVKVCHWTKEAIRGHAPCYKQTFYGIKTANCLEMSPAI
TCNQRCLHCWRDTTIFSKGWVGPVDDPKDIIKGCIEERKKLLIGFMGNKNVEKSKVQDAL
NPKHAAISLTGEPCMYPRISELIDEFYAQGFESVYLVTSGTVPEALEKLNKLPTNLYLSL
TAANLEQYKELCRPVEIDCWQRIQKSLDLMSKINTNTVIRITLIDKLNTENPEEFVPYIE
RAKAKYVECKAYMHVGYSKDRLTEAHMPSMETIRKFGKVIEENSNYKAKDERSDSRVLLL
ERTAKR
>A0A4Y3FWF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MKNVTEIMEKQGYRIIGTHSAVKICHWTRERLMRKRSCYKAKFYGISSHRCIQMTPSFAW
CQHSCLFCWRPVEHTLGTDDIKEPQEPSYIVEASLEAQKKLISGYGGEKERVTQQEFREA
NSPAHVAISLAGEPTNYPYIGELIDEYHRRKMSTFLVTNGMNPKRLEEVNPTNLYISLIS
PTEEIYKRLNRPKIKDGWERLHESLEIFSTSKTRKVVRITLVKGYNLEVPELFSKLIEKA
EPDFIEAKGYVHVGYSRKRLERSHMPSYEEVNSFSDRLSRVTDYTIKDSSKDSKVFLLSK
G
>A0A662UCD5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVRRKKIKIDFEEAKKDPYKVLFAILRKQKYHIVGHHSAVKKCHWTHAALTEGRFCYKCK
FYGIETHRCVQMSPSVLWCWNSCIHCWRLRPKDIGIEWDQTKLPTVDDPELIVEGALREQ
RRILSGYKGNPKVNRKLLEEALNPKHVAISLTGEPSLYPRLSELIQLFHRKGLTTFLVTR
AIRPDILANLDEEPSQLYVSFEAWNKEMYYKLNTPLAPRLWELSVKTLEILPSFTCPTVM
RITVMKGINMSKKDAEGFAKLIELAQPTYVEVKAYMHVGASTKRLPRETMPKHVEVKEFA
KLISEKTSYPIVSESIPSRVILLSRLKKPIRLGKGCPGGWRTPDIGGEESGEYGKYASEI
>A0A674MNS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
IDIFFQQKSHISADYFMAIWHNRLYLYSTAALIFGIWFSLKMAIKKKNQDSNANSLAYKP
VKKNDKDSMVHVSGVKIFYGSQTGTAKGFAKELSDEIKALGIPAVVLDMKDYDPDDELAV
ECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVY
VGHYNTVGKNVDKWLWMLSGKRIMTRAEGDCNVVKSRNGSVQADFLAWKVKLLKRLQALA
RGEKKICSGNCKTEGKCKNKRKVKGEENAALQNNSSEGELIESSSDEEESGLQEEKQSGT
MLDMEDLGNIMNLVNKTKGQTVKLSKLNGLKKTEEEEDVREMITPALREALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWRWKMDPAEKILQDALEKHQNMIRQFRGVPGVKLERYEEGLEVKHCALSLVGEPIMYPE
INTFVRLLHTHNISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDYW
PRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSA
SSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYE
RFQELVGVYEKTGGQRSFSALDYMAKTPNWAVFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A3R9EQF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A401L3Y4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus awamori|TrEMBL
MEGSGNEGLLAFWHSYRLPVLLALATLLVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISNSTKKDVGADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPAVSFI
QPIIFFASLTANTERYAQVLLEELRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSRGLQDIL
GEIVENGGLGEGVPGSGDPLESDEEDLDDEGSESDKANGRKRNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPF
YEEVQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQAAAATEAQG
>V4V7Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Citrus clementina|TrEMBL
MAIARLARLGRHAKRPHGLCVKMTAVAILGLCFIFAWSTFSSSANSVTTQRESFDDIAEP
VSADTKVISSKPQYTERKRQWHEIGKEEDKKVKLESDLDKAKEKKINGSASVTVIKHESR
KKNEKTVPNVKKQKHTVKSVNEETNEENEKSESDDSLKEDEEEQEQEVVDGKEEESVRES
EVNGETEGDVDLVQQENEQSVVTVEGESGRSRSTGKKRKVKGPVFDPKAHYSWKLCSTRS
KHNYIPCIDNESGFGKFQSYRHTERSCPRSHLMCLVPLPHAGYGSPVSWPDSRLKILYKN
VAHPKLAAYIKKHNWLVESGEYLTFPQNQSEFKGGVLHYLESIEEMVPDIEWGKNIHVVL
EIGSADSSFVASLLDKEVLTLTVGLKDDLVDLAQVALERGFPAVVSPLGNRRLPFPSGVF
DAIHCDGCSITWHAHGGKLLLEMNRILRPSGYFILSTKHDSIEEEEALTTLTASICWNIL
AHKTDEISEMGVKIYQKPESNDIYELRRKKNPPLCKENENPDAAWYVPMKTCLHTIPSSI
EQHGTEWPEEWPKRLETYPDWLNDKEKLSSDTRHWKAIVDRSYLTGLGIDWSKIRNVMDM
KSIYGGFAAALAQQKIWVMNVVPVHAPDTLPVIYDRGLVGIYHDWCESFGTYPRSYDLLH
ADHLFSRLKSRCRQPVSIVVEMDRILRPGGWAIVRDKVEILDPLEGILRSLHWEIRMTYA
QDKEGILSKRLHALLTSNDLLFDLVDPQTYEPEDLSKEALVLIVASSWEDGKPAEAAKFF
MNWIDESANDFRVGSLLLSNCKFAVFGVGSKSYEKTFNMVAKDLSKKMRELGAGEVLPVV
EGDVDGGELDVVFEDWSKRVVAILKSGGDRVENGIVNGEASIVGVESDPVYHEYDDDEEE
EDVVESEMVDLEDIAGKGPSRRSVNVAETNGKVKDSKRDMVTPVIRASLEKQGYKIIGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
QWKMDDPIEIVNTAIDLHAKMIKQMKGVPGVTLERLNEGLTPRHCALSLVGEPIMYPEIN
TLVDELHRRRISTFLVTNAQFPDKIKLLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWER
FLDSLKALRDKQQRTVYRLTLVKGWNTEDIEAYSKLFSIGNPDFVEIKGVTYCGSSATSK
LTMENVPWHADVKAFSEALALRSEGEYEVACEHVHSCCVLLAKTERFKVNGQWFTWIDYE
KFHDLVASGRPFSSKDYMAASPHWAVYGAEEGGFDPDQSRYRKERHHKSSR
>A0A5E4LTD8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MSCSGEVVETSNDFIQIKPMITNQLKKAKYGVSDHGTVELCHYTKKSFKNGGDCYKHKFY
GISTHRCMEFSPAGMFCENRCIYCWRPMEFYSAMKMSPDKVAPPETIMSNLMEERRKLIM
GHYGDPRSDERKLDESLIPSHYAISLSGEPTMYPQLPELIQYLKKLPTTKSVFLVTNGQE
PEMLERLRDEDALPTQLYLSTNAPNKEIFLTVNRPKYADAWERWNTSLEIISKLDTRTVL
RLTLIRGYNSGDELIPEYSKMIRNSDIHFIEAKSYMHIGRSTNRLERSDMLEMSEVRHFA
YEVARQSEMYSIMDESDISRIVVLQNQNRFTDRWIAAYANTN
>A0A7L9FL53|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Infirmifilum lucidum|TrEMBL
MVAVQERLDVQRYLRAGYRLVGKHSAVAICRWTRAALRGERLCYKSWYGIQSHRCVQMTP
VLNFCDFSCRFCWRMHQPGRFKIPVGWRWDGPDEIIDGSIIAQRLLLVGFKGNPQVSRER
FLEAMFPRHFTMSLDGEPTLYPLLPELIKRVKERNMTAFLVTNGSIPVRLEQLVKKDAQP
TNLYVSVYGPSEEVFNYTADPRVPRAWEMVQRSLELLDKFNESRTVIRFTMVKGLNMVDP
EGYASLVKLGNPMFVELKGYTWVGESQKRLPITAMPTQEEILKFAGEISKLTGYQVKLTD
EKSRVVLLVRDEDAWERNLKMREEWFKTVEKLDEQWKKKVQDFAMEEHGYRMLVY
>Q56XF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabidopsis thaliana|TrEMBL
MSTTSSVRVRLAFVALLSATTFYCIHKYRRLKHLKNLSLNPSSTLKASRGKIFFISQTGT
AKALAQRLHELCASNDIAFDIVDPHSYEPEDLPKETLVLFIASTWDGGKPPKNGEFLVNW
LGESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEGD
VDDGELDRAFQDWCDGVIRVLKGGSAQETNGVSQQIGAVEDDLEYYDSTDEEDEDNDADG
GIVDLEDIAGKAPSKRNGVVKVTKVDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDEPSV
IVKGALDLHKNMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGR
RISTFLVTNAQFP
>A0A8C1PZN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKVIKFLTACVIVIIIYLSNLKNYMQLCCDVFLAGDVIAQGIQCEVMDMKEYDPEDRL
AEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNS
VYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQA
LAKGEKKACSGKCKKGSCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSDAESSAEEEKS
HGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWSWKMDPAEKIIQEAVENH
KNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTN
AQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYR
LTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQ
LANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSA
MDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A8C2JD09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKVINPLLDKSVKNQKRSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVIAQGIQ
CEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKT
YLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQA
DFQAWKAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSEEELM
ESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKTKVKTKPCRSTVVTYRYKLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFL
RLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQEL
IQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>F7W2C7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)|TrEMBL
MAFEIPLVDPVTVAEVARYAVELWHEHRIPILLSAVFLLGLLRTYLHLYSEPRQELLVLP
KIYETDKKTKETANVEKEIKEKTGIAKKEKASNGGPKRIKGDKVRTKKGTNGNDSGSESE
GPRKIQVLVFYSSLTGNTERYTKDFAKELGDLLLGKSEAESNFLAPQVLDLAEIDYDEYF
ISPPKATADGPVDYFYLLIIPSYNIDSINDTFLAHLDETHHDFRIDTSPLAPLLGYSVFG
YGDRDGWPTEEEGYCVQAKQVDKWMAKLTGRKRAFPLGMGDYKRDGKERLSEWQSGVVDV
LKMIEQTGSLGEGVPGSGEPIESDDEDIAEDDGEVVYEESESKKTLEDVEDLGRIIKQTQ
GDGQAAPIAIDFTDFGKTGKAVRAKKTATVTIKEMVPVGSPTYTSLTKQGYAIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTSWRWV
VDPPDLIFNGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFL
GMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKESLRRIDRPLHRDFWERFQR
CLDILRERRFRQRTVFRLTLVKDFNLEDEVEGYADLVEKGLPCFVEIKGVTYCGTSTAGS
AGLTMANVPFYQEVCDFVVALNKALNKRGLKYGIAAEHAHSCCILLASERFNVDGKWHTL
IDYEKFFNLLEEKGPDGDFTPEDYMGAATPEWATWGNGGFDPRDQRVDRKGRPIEAP
>A0A7J3WVK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MISGVLMVTVRTYIDDVDRLRKSGYRIVGRHSAVKICHWTKNVLRGGKHCYKSWYGVESH
RCLQMTPSLQYCNMMCIFCWRFHTINRIATYEGEWDHPEEIFDKLILEQRQLLSGFKGNP
AVDKKLFKEALEPNNIAISLDGEPTLYPYLADLIKLAHNRGMTTFLVTNATMPKRLEELI
EEDAQPTNLYISLYGPDLETHIRICRPLIRDSWIRLNESIHLMPSFEKSRKVVRLTLVKG
YNMKDVEKYAELIRIARPDYVECKAYMHVGESQKRLPREAMPSMNDIVDFSRKLSTLINY
KIISYDMASRVSLLANESSVYYSLDSNRIAGRNYPILL
>A0A2H3T8R8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A5DR76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)|TrEMBL
MFGKALFSLCCALYLLSGGRWTFALAGGIILTLASTKKANEKVTLPQKTTKKPSPIVAVD
FTTTSTARSSSRATPRTAPRPVPKKRTPKIFKGSRPSAQEAAPTESSLTESTNLSNTKIH
IFYTTLTGTSLRVAQSLQEELKTLKLDFQPKLVSLDDDVDDLEEYFLRCPPNSLYVLVLP
SYETDSPIDYFLEHLRETYNDFRVDKYPLQKLVGYAVLGMGDSESWPEKFCYQATSADKW
LAKLGGRRVFPLGKMSIKHNGEEKAQEWIKQFASLVADPEPFYLDREIEDSDNETGSDDA
DTLVDVEDMGDIIRKSGDKPEVKQMVAQDSPTYKSLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSTWRWELDPPEKVFE
GALEGHYKKIKQLRGVPGVQMDRFQEAFTVRHCALSLVGEPIFYPYINELVGMLHKNHIS
SFLVCNAQHPDQLAKLAKVTQLYVSIDAPTRTDLKKVDRPLNADFWERLMSCLDILRTVQ
SHQRTVFRLTLVKGFNMNDVASYADMVERARPSQIEIKGATFCGSSNSNGNPLTMQNIPF
YEECKSFVESLAQELQSRGSDYQIAAEHAHSCCILMAHAKFKINGKWNTHIDYPKFFELL
ESGQDFVDLDYVKETPEWALWGSDEAGFFPDDTKFDRKAEKLRRRLEREEMEA
>A0A8B8V0S3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces paradoxus|TrEMBL
MDGFRLAGAIVVGALIAAYLYFGGRFSIALVIIVGYGIYCNESSGGGQDGPEKLTLNTQR
KNSCCSDKKTADGGKKTGGCCSGKKKSGGNEGGCCSSKGGEKKSGGGCCSSKSGKKGGCC
SSKKKISNNENVAPEVEEAKNFPVTVDFTDVFKKPTKKRSSTPKVFSKSTSSKSKVGKKL
SVSKKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLTELDELTNKP
KLLNLDDLSDLDDYFVDVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSYPLR
RLVGYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKICMKTGGSAKINEWTS
LLAETLKDDEPIIYEYDENADSEDEGEEDNGSDELGDVEDIGGKDGNDKFSGADEIKQMV
AKDSPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSL
ACSSKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKA
FEVRHCALSLVGEPILYPHINKFVQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSID
APTKTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLV
QRGLPCFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLDYDLAAE
HAHSNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFA
PGNTRVYRKDKKKQNKETQETIKRETPLPAIPA
>A0A1A8NDP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius rachovii|TrEMBL
MLRLLLFLSHITAHVASSDTNAQQEAPRSGESYLLWVWTNRLYVYSAAALVFGTWFLLKV
TQQEKHTDSAGPSSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVDMK
NYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGLRY
AVFGLGNSVYVGRYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAWKV
NLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVDRIESSSEEDESGLADE
RTSGSVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGERREMITPALREAL
TKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCALSL
VGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEVKG
VTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDG
EWWTWIDYERFQELVVVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQRRN
RTKDVSGC
>A0A2P5ECV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trema orientale|TrEMBL
MSLTSVQARLTVLALLSATTFYCLYKSRRLRNLRISLNPNPKTSSSSSSSSSSRNGKLFF
ISQTGTSKALARRLLDLLTFNNLAFDLVDAKDYEPEDLPKETLVLIIASTWEDGKAPPDA
RFFTDWLAESAEDFRVGSLLLSKCKFAVFGVGSRAYGATFNAVARDLSKRMRGLGGAEML
PVWEGDVDEGDVDEVFDAWGGKLVKLLKGDGVENGVVLDNGVSAESDAESEEESDDEEYS
PESEIVDLEDIAGKGPSRRSAAVAKTNGINGTSNGKKDMVTPVIRASLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQ
WKMDDPLEIVNSAIDQHTKMIKQMKGVPGVTLERLMEGLSPRHCALSLVGEPIMYPEINA
VVDELHRRRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERF
LDSLKALRDKQQRTVYRLTLVKGWNTKEVDAYFNLFSIGKPDFIEIKGVTYCGSSATSKL
TMENVPWHADVKAFSEALALRSEGEYEVTCEHAHSCCVLLAKTDKFKINGQWFTWIDYEK
FHDLVASGRPFDSKDYMAATPSWAVYGAEEGGFDPDQLRYKKERRHNRSSQVPAGPG
>A0A0D5C0F9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus adriaticus|TrEMBL
MSCSGEVVEADDPLIQIKPAISAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFIRINKPKYDDSWERWNRTLDMLKDLNTRTVL
RVTLIRNYNDQKEVIPAFAEMFRKASPHFIELKSYMHIGRSTNRLEHANMLEMEEVRKFS
EEIAKQSKIFSIMDESIVSRISILQNNERYIDRFIPTYANTN
>A0A8J8A9Q5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. MV11|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIASH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKIKETLGLMKDAQTRTVIRLTLVKGE
NMHNPEGYAKLIRLASPMFVEAKAYMFVGFSRNRLTINNMPRHGEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTGIGGRFIKH
>A0A1X7S2X2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zymoseptoria tritici ST99CH_3D7|TrEMBL
MGDSHLLQLPQELLLLWHAHRTEILISAGFLVAIVRLTLHWRSTKTKAILTPPLGSPVTE
KPIRFPEVVQEKTVPTAQPVKTNGPRRVKGVKKVKKQEQAKDERPPIDKIQPYIFYFTLG
GSTKAYAEKLAESFILPDAKDRVLPPQVHDLTDIDYDDFFISPPKYDSPGTAAFYTILIP
SYNIDTELHNFLSHLQETHHDFRIDTAPLQTLAGYSVFGFGDMQEWPTEQEGYCVQAIEV
DKWMAKLTGKKRAYPLGMGDVKDDVELRLEEWRRGVQTIVDDLSQGKGLGEGVPGSGDPI
ESEDEADEDYDDGETLITITADLEDIRAPIPVDFTTSKKSTSTTTGPPKEMVPVNSPTFN
SLTKQGYSIIGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCVF
CWRHGSNPVGTTWRWQVDPPEQIFEGILAAHYKKIKSLRGVPGVRSERFAEAMRVRHCAL
SLVGEPIFYPHINQLLAMLHAQHISSFLVCNAQHPAHLAALGPVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFCDCMDILRQKRYSHRTVFRLTLVKGFNIADEVAGYADLVQRARPGF
IEVKGVTYCGTSTSAGAGLSMANVPFWEEVQEFVLALAAELKTRGVQNDGMEYGLAAEHQ
HSCCVLLADKERFYRENAAGEGKWHTLIDYEKFFKLVEMGGEFKAEDYVSAEPTADWAGW
GRGGFDPRDVRVDRKGRPIEQKDEGRVVEI
>A0A7L3B5Q2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pallas's sandgrouse|TrEMBL
LDVTMDTWDFSTCLVSLWLHRVYIYSVIAFGISIWVTVQFFTTKKKGENSNWDPASSEGI
QDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVLSLNLPVEVISLGDCDP
DDCLMEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLGARRIMTRAEGDCNVAQSKHGSVEADFEAWKAKFLG
RLQVLCRGEKKACSGKCKKGKCKSPGKQSKEGSDHEHGASEYENAEAEELFETSSEEEPD
AEEAAGTNSVIDVEDLGNIVNHMKKAKKSSIERVMLKNFVYPLICFGYQLLEVKIDGLIY
FLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKADRLEEAMIAKHCALS
LVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWPRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKDYADLISLGKPDFIEVK
GVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLMAHKKFKID
GEWHTWIDYDRFQELVREHERSGGSKAFTAADYTARTPHWALFGSRERGFDPLDVRYQRK
SKVRDISGC
>A0A7L3B5Q2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Syrrhaptes paradoxus|TrEMBL
LDVTMDTWDFSTCLVSLWLHRVYIYSVIAFGISIWVTVQFFTTKKKGENSNWDPASSEGI
QDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVLSLNLPVEVISLGDCDP
DDCLMEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLGARRIMTRAEGDCNVAQSKHGSVEADFEAWKAKFLG
RLQVLCRGEKKACSGKCKKGKCKSPGKQSKEGSDHEHGASEYENAEAEELFETSSEEEPD
AEEAAGTNSVIDVEDLGNIVNHMKKAKKSSIERVMLKNFVYPLICFGYQLLEVKIDGLIY
FLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKADRLEEAMIAKHCALS
LVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWPRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKDYADLISLGKPDFIEVK
GVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLMAHKKFKID
GEWHTWIDYDRFQELVREHERSGGSKAFTAADYTARTPHWALFGSRERGFDPLDVRYQRK
SKVRDISGC
>A0A1Q9DNY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium microadriaticum|TrEMBL
MEDSSNPVSLDWAASVNLPMDVEAVAATQLDPAKQLDPATPPEEALTATALLSPVKTSPT
ASASSTFATVKEEQPHLVHLTSDGFWHPVLERLLQGKKHHSYKRKVHESKAFESITQWAQ
RSGLRLPSTQRSTSAAVEVPPELQRLPEGLPPPAEPRALKASPPAKKPAMVLPLSRSAST
STRLTARLQFYKRQHASEDCRLESLPVGFRGGSPRKRAGACRTAVSLSTLKLGASHLELH
LQETGPRVDSETAVLQAPVRFRGLPPRKPACKAFEAAVLGSVLVYKRQYASEDCRLESVP
VVVVCRAAAQEVYSLDAQDVLLQQLHWRAQRSARQLKVWKQWFDQQTSVVGSTDAALPEA
LRFGRSSGILCCNCTGGESKGEQLEWLKRGCHIIVATPGRLNEALGQVLFPFVGPAEDDF
VGTADRMLDMGFEPQIRRIVEDCPTRRQTLLFSATWPKVTSPHLWGTPQALATLAICGLG
EDAVALIKLAAYRRKPRCSRACRWRCWVLLLAGCAACDLRGHEFEIELKESISMPIPPGF
TALSPQLPGKLVVTSFEATPFVGKNGVFLVDVGSHSGPAQELPGSSKINWPNSITTLNAS
VFGFTAVAIGNGFLVPTHTTGGVYVMEASTQPATLQEPVKISKDLSGWFYHQAHFVDMDG
DGLLDVLTARCEYAVWPWAKKRGELVWLKQPAKDALAGPPWEEHELGPGPDFLFCVHPNS
SRLALVAPEFVSGRVVYWFMQQNGTMSSRLLDDTIGPGFSCSWTDLNADGHLDLLVTNHA
AVNGSVFAYSFSSDDIASSQITRHVLATGFTPAKIDKGKASPGDALAFQPQTNSTDKPYI
FVSGDNSNSIFLLTPVSKDQSDWRYSLKEVQDFGADIGRPSIGDVDGNGFADIFVPVYDS
KRVVHYEFRLGLAAWARRRAASGDRSSGGPIVRVRILYASMSGTSQATAVALEESIRRAL
PERSLPPEAKLQISIEDLSTFAFDTLLARTDGVSTDFVALLLSTYTDGLLPPSSAHFGTL
LADHVHDFRVGRSAMSHLHFAVMGFGSSVYADAGHFCTAAVWALADVQVRADAALAALGG
LRVARLLRVTDTKELANQASEWQLELQSSISAALRGLEIPKARGIEGNAAAEAAVAQTAD
QEGEEDSSDSEDDSSTTVSSGVLDRPGQSKSVLFTPASHPEVDPANDAPIEMDRSHELDP
LSHDELSKKYGVGFSILRRMGYSGAGLKPGGLQAPLAARANVGRQGLAEAAESSGAASIS
QEELEQPAVDLTNLLSQALRSMREAGDEEEANELQHLATFCNLGEAGGVLETLLPTPPKK
RKQKIQAPDTAKVDDEPALRCLLGCFQNSNFPVEGEEQARFMKWNTHWAPSVGSFEAFVA
RHKPELRAVACPGGLWLLLPREGQGESTEECLQRKCIDFCQQQAHARGKCQGRRKWQHLL
KTLQRIFKGRRPAGKVPPPEASSARCDPTSSAGPLESESLDEPSDVDASLGWAFDCGDHS
RLQTETAEKKHPNARYHGSEAPAKGSTSDVEELAEGCAGDTVKKPEERQMLTTKHRAQLT
KEGYKIVGSHSAVKLCRWTKHQLRGRGGCYKHSFYGITSYQCMEATPSLAYSDQDEDLED
AAQRRGRNPSIKFTASSWVIRIALSQINDEELEPWEVFLAANERHLLKSTTSATFMKLDG
VLEAFLETRMRPLNSYCRGPQREPSHQFGSADISEVEEAPANGRVADVMYFTEVFCCNFL
SSFVDQTHAMQQWLHFVSRENSGLRATHALARRIACPFRDGPRLRTWLYDSFVALQAAFY
SPNGEAPDMREDLMDHASMTIGDFIKLDETIYMVGLDGFFELKMGVDEEVIRLDDFIDRN
ASFEKQSDDEDTADESSKPDSSTGSSSQEVEIDPTLNEEDEVQAKGPKSPAKEAFRRAPG
LFCGASNADGLFCGASNTDGANKCVFCWRHHKNPVGTEWKWSMDPPDQIVAEGIDQHRRM
IRECKGIPGVKKERFEEAMTVRHCALSLVGEPIMYPRINELVGELHQRKISTFLVTNAQF
PEAIRNLDPITQLYVSVDAGTPETLKAVDRPLFSDFWQRYLDSLKALKAKKQRTVYRLTL
VKGHNMEEAANYAKLVALGTPDFIEIKSVTFCGESKASSLTIECTPWHEEVKAFSEAMLS
KEGLESQYELACEHQHSCIVLLANKRYKVDGRWHTWIDYDRFHELVKAGVEFDATDYWAP
TPEWALYGSEEAGFDPNETRVYHNRTKKRAQAGLLSKEQLKMYPDNPAKQ
>A0A2P8YNF2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blattella germanica|TrEMBL
MAQQWSHSLLVLLVGMQHMTESARILGIFPGPSFSHHLVFQTIMKSLAARGHEITVIGTD
PLKVPVKNYKDVDLSFMYDYVRENYNFTDYQEVTAFGTVLRFSIYVAAACTMQLGSTQIQ
EFLKEHPRGSKSFDLVFMELSRYQCYYGLVHHIGSPPVIGIRSVGITAATLAAVGNPNNP
SYFPDYYLPYTSHMTFFERVHNTALYVWSRLLWHLLMMPIHEVAMRYYFGWEPPSVWTAE
NNISLVMVNNHWSQSYALPLVPSIIQLGNIHLQDKPKPLPKDLKDFMDGARDGVIYFSLG
SNVRSETMPEDKKKAFLSAFAELPQKVLWKWEADYMPGLPDNVKLAKWLPQQDVLGEFVF
YDVPDKPLQRAIWWTEYVLRHDGARHLRSAALDLYWYQYLLLDVFAALILTVAVVSYVIY
MIVKYIFKFIKFATKYSSTKNAKKKSQADKKRIGAFFIIWTFTTKKKELTCNEQISSEGK
ANGHVVTSETASATSVNAKKKRKVYGKKSGTFSRSPRFESKAMAFPERLENVSTYSFDEQ
PKNKKKKKPCKKGLAGCCSRKKGARQPLEGTIDTVKVFYGTQTGKSKIFSSGITRYCEER
KLNVETAGNTLCVFILPTHSEGKPPESAAWFCKWLGEAANDFRVEKELLKGLKYAVFGLG
NSQYKDHFNQVAREVDEWLEELNACRFMKLGVGDEDTSGSKHGSIEADFEDWNNRLWVRV
DKFLKTHTVCQCDGTEQEKAHTSSESSCDSDGSCSSEDNSGQDESGIMDLEELGNFTGSL
RAARDKTFDETGPLKEMVTDSLKESLVKQGYRIIGTHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCVETTPSLACANKCVFCWRHHSNPVGTEWRWQMDPPEKIIEGALEKHYKMIQ
EFAGAPNVIPERYAEGMNVRHCALSLVGEPIMYPAINQFVHMLHERKISSFLVTNAQFPK
EIREMSPVTQLYVSVDASTKSSLKKIDRPLFKDFWERFIDSLKALSEKGQRTVYRLTLVK
SWNVEELEGYAKLVDLGKPDFIEVKGVTYCGTSKASSLTMENVPWHEEFKVDGEWWTWID
YDKFQELVEKYYATNGEAMFTAEDYMKKTPEWAVFGASERGFDPKEIRWRRKNAKNKDIS
GC
>B9AEQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter smithii DSM 2375|TrEMBL
MSLNKKQVEKLESSGYRFVGSHNHAAAKICHWTKQSILDKGVCYKEKFYGIESHRCLQMA
PAVPNCQQKCEFCWRDLSYTQTQWEGEYDDPKTIIDEAVKAQNNLLCGFFGNDKANKEKL
EESKTPTNAAISLAGEPMLYPEIDELIAEFNRRNFTTFVVSNGQCVDKLKNLENEPYQLY
LSLDAPTKKIYNDVCQPQISEGWDNLNQSLDTLASFNSRTCIRTTCVKGRNMINPEKYAE
LIKKASPDFVEIKAYMCVGSSRHRLTPDNMPTFDEVKSFAQKIGENCGKKIVNESEVSRV
VLLQ
>A0A178CF76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fonsecaea multimorphosa|TrEMBL
MDLAEAGAAPVILADWLDRILTSWHENRVVLSTLLGLCVLAVIVQRRHAYKIAQRGSPTL
EKAEWLAQNDDAHVQVEKGERNEFPARNTPSLTSGQARKPRTAAAAVRVVTGRKPASSRG
GQAALQRRREPSHIKPLIFFSSLTGTTERLSKQVAAELEQISAAQHAILRPQVYDLSYVD
LDDYFISGPKTPEPNADVLYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLA
GYTIFGIGDKEGWPSEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSNLDKALQDWT
GGVCSVLKEVSKTGALGEGVPGSGEPVESGDEDEPEQGDEEVEFPDSGRNKRRKLANTTD
LEDVGGKANSYAAPIAVDFTTYNSAPSAPTALKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPELIFEGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNS
CLDILREKRFVQRTVFRLTLVKGFNIDDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALDKALAKRGLEYGIAAEHAHSCCVLIASKRFLINQKWHTL
IDYDRFFDLLDGPKEFKPEDYCRETPEWALWGNGGFDPRDERVDRKGRPKVKKAGGDDGG
EDKTGASTGEGKAQWDF
>A0A0F2LQQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aramenus sulfurataquae|TrEMBL
METPKFRIDTLSRIVDEMEKEKYHIIGSHSAYKKCYWTHKALTAHRYCYKGKFYGIESHR
CVQMTPVAAWCWFRCIHCWRLEPEDIGLEWDETKMPVSDDPEYIAERSIEEHVKAVSGYY
GREGVDKELVKAASRPAHVAISLTGEPTLYERLGELIKEYHKRGMTTFLVTSGVRPDILA
SLEEEPTQLFVSLQAPNERKHKLINRPIVANSWNLVMETLRMMPSFSSPTVIRMTMIKGF
NMSEDDAREFAKLIEISMPTYIEVKAYMHVGPSTYRLSRDAMPRHREIREFAELLAKYTG
YKILSEHVPSRIVLLSRLDRPIQIGNAWTQKWDWRAKDKEDDIHGEYEEAELGCTEGT
>A0A2N1LU18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma harzianum|TrEMBL
MDAGSRLQLEAMVADLVEVWHIHRTTIILASLFLLAGLRIFLHTTEKREPLAALPKIYNQ
EQPKASEKPIVKAQPAVDTEKKSTGPRRIKGGLTRKSSQEGKPATNESTDRPAKVLVFFS
SVTTKTEKIARDYINALETFVDQKAKETDGKFLKPELLDLTEIDFEDYFVSPPKSAEGVA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHAERFAEWTSGVQDVIAQAAQTGFLGEG
VPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDVEDLGKMIRTKDGNEGT
RKAPLAVDFTTYTSANKKKAQAPIIKEMVAKDSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLAEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQKFF
ELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>A0A843D8R8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MDEDYKNLLIKQQYRLYNDHAAVKLCHWMKESMLHERHCYKQDFYGIQSHRCLQMTPAIN
ECSHLCTFCWRVQNNDFEVTDWAEPKEMLDALINEQRKLIQGFKGDPRCDPKRFQEAMNP
NQVAISLAGEPITYPYLSDFLKECHSRGMTTFLVTNGTYPERLAELDELPCKIYVTVAAP
NEEIYRKVCRPKIKDGWQRLMKTLELMPSLDTGTVIRHTLVKGHNLGWTDEYAKLDNIAE
PELIEPKGYVFVGGSRQRLSMDCMPSFQEITDFANELGPKVGMEIIRQREDSRVVLLGHP
GQELDVRAINDLK
>A0A843INL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MDQAYKDLLIKQQYRLHNDHAAVKLCHWMKESMLHERHCYKQDFYGISSHRCLQMTPAIN
ECSHMCTFCWRVQENDFEVKDWSEPKEMLDALIAHQRKLITGFKGDPRCSPEMFEEACNP
NQVAISLAGEPITYPYLSEFIEECHRRGMTTFMVTNGTYPERLESLDTLPMQLYVTVAAP
NEDVYRSVCRPKVSDGWEKIMKTLEMMPSLETRTVIRHTLVKDVNLGWIDDYARLDRIAD
PDLVEPKGYVFVGGSRKRLSMACMPSFEEIKDFSRQLGDRIGMELIKERADSRVVLLGHP
GEETDVRKIYGI
>A0A3N4K9X7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Choiromyces venosus 120613-1|TrEMBL
MAESQIHTAQFLGLWHSSRYPLLFLGVAVVLVLKLRSYIRNFEQRESKGLMALKPTTWVE
DPAKPEPKPAVKPKVAPRRVVGKKKSLKPKNGGKVVAEVEEGEFDIQPLIFYSTLTGSTQ
RCAEELRSRLFSVKGESIYPTLSIPTPSNSLGSVPIQRSFLPPVVYNLEEVELDDFFITP
PNEIGKKVKYVYLLLLPTYETDAPIRPFLEHLQETHHDFRIDTAPLCSLAGFSVFGFGDS
SEWPAEEGKFCKDAVEVDKWMGKLTGGRGGTRRMFPVGMGDVNPAVGLNSAEKSLDEWRI
HLEDAMREYAATGALGDSADWRTAVESGDEDSDFEIVDAADDMVDVEDLGSVIRKNSEVA
KKGDVVKKKTVLPVDFTTPAGKKALEAGEGQSADRKEMVPKGGVTYEALTKQGYTIVGSH
SGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTW
RWKVDPPEEIFKGVVEGHYRKIKMMKGVPGVRADRFSEAFKIRHCALSLVGEPVFYPYIN
EFLHLLHSSKISSFLVCNAQHPAQLAALGHVTQLYVSIDASNKDSLKKIDRPLHRDFWER
FQQCLDILREKRNQHRTVFRLTLVKGFNIEDEVQGYADLVEKGLPCFVEVKGVTYCGTST
AGEAGLTMKNVPFYEEVVAFVEALNAELGKRGLGYGIAAEHAHSCCVLIASNRFFINGKW
HTLIDYAKFFELLESGKEFGPEDYVGEATPEWANWGNGGFDPADQRVYRKGKGPKEEVEE
SGGCG
>A0A0V1AWI3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella spiralis|TrEMBL
MWKAYYSMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVFDLQHYNPEGHLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKICR
WTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPA
EKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMH
SLNISTFLLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILREKKQRTVYRLTLVNRY
NMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKDSKITMANVPWHADVVDFVQQLVFQLDD
YDIAAEHEHSNCVLIAKLNFKIHGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMAKTPD
WALFGASQRGFDPEDQRWYRKSKGS
>A0A2K5AQX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosocaldus cavascurensis|TrEMBL
MSCADEHVQDLIQIKPSIARQLRNAKYGVYNHSTVELCHWTKKSFMDEGTCYKHRFYGID
THRCMEFSPAGMFCENRCIYCWRPMEFYEHIEMPRDAVDEPQAIIDNLMRERFRLMSGYF
GNAGTNKAKLIEAMRPTHYAISLSGEPTMYPKLPGLIRYLKSLKDTRSIFLVTNGQEPEM
LYRLEEEDALPTQIYLSTNAPNKRLYYLINKPRLRDAWERWLKSLEFIASTNARTVARIT
LIRGYNYGLDIAREFAEILRIGNPHFIEVKSYMHVGNSINRLSADEMLSMDEVLAFTGVL
EYHLDDYAIYDWSVPSRVVVLQNMKRYVDPIIH
>A0A7D5M3G4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus cobalaminigenes|TrEMBL
MSCSGETVEEEEQLLQIKPVISAQLKKAKYGIADHSTVGLCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPEQVAEPKQILTKLMGERKKLIN
GFYGDSRNDKQRLDESLLPAHYAISLSGEPTMYPKLPELIKYLNSLEATKSVFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFMRINKPKYDDSWERWNRTLDMLKDLDTRTVL
RITLIRDYNDQKESIPLFAEMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMEEVKKFS
EEIAKQSKIFSMMDESIVSRISILQNNERFIDRYIPTYSNTI
>A0A1S3BAY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cucumis melo|TrEMBL
MSFSSRSAKLTILALLSASTLYCFYKSRRLRKLKLSLNPTLSSRKPKLFFISQTGTSKAL
AHRLLNVLNSNGLVFDLVDPKDYEPEDLFKETLVLFVASTWEDGGPPPHAKFLANWLSES
AEDFRVGSLLLSQCKFSVFGVGSRVYGETYNAVARDFSKRMKSLGAKEILPIGEGDVDGG
DIDKCFDDWSRKLLKVVKVDAEGNGVELCSGIAGDSDAVSVEEEYEEEDDDLGEEDIVDL
EDIAGKGPSRKSTNVVETNGKLNGKKVMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPLDIVN
SAIDLHTKMIKQMKGVPGVTQEKLEEGLSPRHCALSLVGEPIMYPEINTLVDELHQRRIS
TFLVTNAQFPDKIKLLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKALNEKQ
QRTVYRLTLVKGWNTEDIDAYSNLFSIGRPDFVEIKGVTYCGSSNTSKLTMENVPWHSDV
KSFSEALAAKSQGEYEVACEHVHSCCVLLAKTDKFRVDGQWFTWIDYEKFHDLVASGKPF
DSKDYIAPTPSWAVYGSDEGGFDPDQSRYRKERHHKPKPTS
>A0A0V1PB89|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella sp. T8|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDICERCVVMIHFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLV
GTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVG
TEWKWKTDPAEKILSDSLEGHKKMMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAA
SKESLKEIDRPLFRDFWQRLMNSIDILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQ
PDFVEVKGVTYCGDSKDSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIA
KLNFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQ
RWYRKSKGS
>A0A3L6JKQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPPELREKLVRQGYDILGDRGAFKACQWQKKSLLLGDVCYKQRFYGIESHRCIQITPLVD
KCNQECQFCWRVTPSDIGVTWDQTHVSEPEFLEPKQLLDAAIMANLRSLGGFNPKVAACV
SEEKYREAREPRHVAISLAGEPTLYPVISGLIDEIKRRRMTSFLVTNGTRPEVLSRMSLP
TQLYVTLAAPDEETYRALCRPKDSDGWTQLNKTQELLSSLKCRRVNRLTMVAGRNMYDVR
SYARLVMKGEPDYVEVKGYMFLGTSRQRLSLSNAPSHRDIRAFAEKLSSITGYRVLDEQV
ESRVVLLSRDSQIERMNVQ
>A0A094E0U0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-103|TrEMBL
MANNEYFGADIASHASENYFMALWHTYRIPLILTALALLLITRTVLHLKVGREKIVYTPP
PTPSEKPPLAANHQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLGDKPASKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLAPIAHDLAELEDYDEYFLGLPK
PEDDSQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAKERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEEAEDDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQDESEEQDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
GAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEEKWH
TRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEG
EEAEVEVETKPALVEI
>A0A662LE81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MPVLPHVREMLRKQHYYLVGEHGAVKLCHWLKKKLTEGRACYKENFYGINSHRCLQMTPA
VDICNHACIYCWRYQAPQEWPLNVRSSGGWDDPRELVEGLIEGQRALLTGYKGNPKTNLR
LWEEAQNPNQAAISLSGEPTLYPHLSELIEEFHRRGFTTFLVTNGTMPEVLERLDPLPTQ
LYISVDAPNERIYKSLCRPYIRDGWERIKKTLELLPSLDTRKVVRHTLVEGWNLGYVKDY
ARLDKVASPEFVEAKAYMFVGYSRQRMRIDNMPSFERIKSFAEELSRELGYTYHAEQPPS
RVSLLISDPKRVKVRLDN
>A0A662LAS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MQFDDIKKILEEQGYAIVGKHSAVKLCHWLRKSLLENRPCYKNTFYGIESHRCLQMSPTA
FHCTQKCLYCWRYQAFTLTKLKKEDADDPAFILEKSIEEQRRLLTGYKGDERVSLEKWKE
AMEPKHVACSLTGEPTLYPYLSDFFEECHKRGMTTFLVTNGTNPKALEEMDVLPKQLYVT
VAAPNEEIYKKLCCPLVPKGWEKLMETLELLNSLDTRTVIRHTLVKYWNLGHEKEYAKLD
EKANPWFIEPKGYMFVGYSRQRMKLDNMPSHEEIKKFGEKLAELLGYEIEAEREDSRVVL
LGRGKQRRIK
>A0A662MFC2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MVVPQLESILRRQGYYLIGNHSAVKVCYWTKEMLVNRRPCYKSTFYGIRSHRCIQMTPAV
DHCTFSCLHCWRFQGFTNVSFEEDPDDPDFIVEESIKGQRALLSGYKGDPRVPKELFEEA
YNPGHVAISLTGEPTLYPRLPELVRAYHRRGFTTFVVTNGSVPETIERLINEEEPTQLYI
SITAPNEELHRKINVPRIKDSWSRVNRSLELMSTMKARRTIRVTVIKGLNMNDKYIEEYA
KLLEKADPDFIEVKAYMYMGYSRYRLKPENSPKHFEVKEFASKLANAMEYIVASEREDSR
VVLLTKPERERRVNRFLELE
>A0A842X7Y4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MEEAIKLVLRKQGYMLTGENSAVKLCHWFRESILHNRPCYKETFYGIRTHRCIQMTPALN
QCTQNCLFCWRFQGFTETYLKVVDDPVQIVEGSIEAQRKLISGYGGNPDADQQKLREAYN
PRHVAISLTGEPTLYPRLGELIEEYHRRGITTFLVTNGTMPEVLENLDPLPTQLYVTVAA
PNEDIYKRLLVPLISRGWERLNKTLELLPSLDTRKVIRHTLLKGWNMEQIDEYARLDLKA
DPHFIEPKGYVYVGYSRERVTKESMPSHEDIRNFSRKLSDLTGYYFSDEREDSRVVLLEK
YRNFPKISSV
>A0A1Q9N787|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Odinarchaeota archaeon (strain LCB_4)|TrEMBL
MSMSIIPSDVRKQLLKQKYHIVGAHSAVKKCRWLHKSLVENKACYKEKFYGIRSHRCVQC
TPAVIWCPNYCVYCWRVMPQDVGLNWDPLGVKSITGDEPEVIFEGFLREQRRILSGYNPE
GNRKVDKVKWLEAQDPKHFAISLSGEPLLYNRINELIEYIKNKGKTVFLVTNGQEPERLA
VLNEPTQLYISLSAPNKEVFKRTCRPTYPDGWQRLQRSLELLSTFKCPTVLRLTLVKDIN
MVNPEGYAESILKSNCHYVEVKAAMFVGGSLFRMRFENMPRHSEIKEFAEKLADLTGYYI
IDEVLNSRVVLLSRVKKH
>A0A423X173|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Valsa malicola|TrEMBL
MEFEILEVSPWLAQLSDSGVDYWHTNRTAIILLAVTVLLLVRVYFHFTEEKEPLHVFPKV
YGTENKIAKVEEKVEVATRIKSTGPRRIKGELTKRKDTELQPGRRQIKTIIFYTSLTGNT
EKIVQEFVKTLAGLLESVTTSSTCAFSNPEVLDLAELDLDEYFITPPKLEEQDGVKTEIF
YLFLLPSYNIDSTNDTFLEHLKETHHDFRIDTAPLAPILGYSVFGFGDREGWPTEESGYC
FQAKELDKWMAKLTGRKRAYPLGMGDPKRDGTERLGEWTNGLIDILGQLARDGTLGEGVT
GSGDAVESDDETDIDEDDGEVIFEDDTQSKPTKSKSSGGTLDDLEDLGRILQNSKNDGNA
KPAAPLAIDFTTSSKRKQPVQTVKEMVPVNSPTYNSLTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWVVDPPDLIFN
GVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHKERIS
SFLVCNAQHPDQLAALNHVTQLYVSIDASDKESLRKIDRPLHRDFWERFQRCLEILREKR
HKQRTVFRLTLVKGFNIDEEAKGYADLVEKALPCFVEVKGVTYCGTSTSSNAGLTMANVP
FYEEVCSFVTALNRELERRGLNYGIAAEHAHSCCILMGSEQFRVNGKWRTLIDYDRFFDL
LEEKGPDGDFTPEDYMGGETPEWATWGNGGFDPRDQRVDRKGRPIER
>A0A8H4F090|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor circinelloides f. lusitanicus|TrEMBL
MSNFINSLLYGFTNILSVGPEQPREGQENEGGCSGSNGEGCCKDKPQEPKAKSGCCQGDN
AGDACCSSSAEPASAETSKEDGCCQSTPGKSSCACESASNEPVIIDNLKIIFSTLTGTAK
TMAAEIENKINTNERVTVNKIEVMDVTEYDNDNLLQETAVCVFILSTYNVEGPLDWFSNW
LHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAANIDKWLGRLGATRIYPLGECD
KNADQKGQFDVWSNGFVSELEDKHSLEFSPTNIAFQSDDEDDEASAEEEEQQPDIDIDGS
GSGDEMVDLEDMGNMASKIKAAKAKRAEEEEDFENSKAKAKRLIGTDAGNKPKTAPQARE
MVSPMILKNLTKQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSL
ACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQLKGVPGVKAERFQEA
FTIRHCALSLVGEPIFYPHINEFVTKLHENNISSFLVTNAQFPDKIAEMVPVTQLYVSVD
AATKDSLKKIDRPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAEIDGYVELIRR
GKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCQKLVSKLDGDYEISAEHAHSCSL
LIAHKDFKVNGEWHTHIDYPKFFELVKSGKPFNSLDYMAKTPDWALHGHEAAGFDPNETR
HYRKNRKTVVPPVNADINAA
>A0A523YJP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon|TrEMBL
MDSNTKRLFERQGYKIVGAHSGVKLCHWMRQKLLYRRPCYKEHFYGIESHRCLQMSPTLE
QCNLNCIFCWRMQNFSGWEFESVDDPEEMLEKSLDAQKELVSGFKGDERCDPKMWEEARN
PNQVAISLTGEPTLYPRLNEFIELCNSRGMTTFLVTNGTTPRVLERLDPLPTQLYITVAA
PNPDIYKKLCAPQSERDWERLNRSLELLPSLGTRTVIRLTLVDGLNIGWEDEYSKLIEKA
EPDFVEPKAYVFVGASRERLSIENMPSHETVRDFGRRLASRLGFEAVSERTDSRVVLLSS
GKTSPKIH
>A0A0F7UGP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neospora caninum (strain Liverpool)|TrEMBL
MWTSGYLDPRLSSLLSKYGEKRSPSPFPAVHDAESTRAPSSSTNSGDAGSPLSPRTRESE
QGKKQTARPETGRHPPGRAPFRILILFGSSGGTSAAIAFSLFHSLRQQLSSGDGACTPRS
GSVSRGNHGREGSSQEREKNSQPITICRTGDGDSHPEKEERERSDAEPLRDAAVSSSSSA
SVFSLSKKKERKIATSASGGFSEGSRAAETALEKARNFMNEARNASPSSFDPSSRKLWFL
DRACAGGVELLVQSMEFFSFDDLVALLEESPSVHDASSNASSPQTRPSPGASAPCPCPAV
ASSSRSDASEASASSLSASSLSSPSSSSARLLLLFCLSTASQGTPPSAAAAFCADAEDAR
KDFRIGKNILSTCLVAGIGCGSTEYPASTFCRPAKHLFKTLTGHLEALPLLLLPCSSDVP
SPLSASSLASSASAPPRVSAATASSLLLLSDTHTDRSLETKVKKWETEAVRRLVDFLRAS
PNEREIWMSLAKDRKSRERKTLSGGSREAGTTARRGKETSTKVEINGDPQGERVTADEQS
AHGATGRDAKGESETEGEASSVDAFSSAVSSGEESDLDETSSIFSSEDDEAEGRTERLAT
SVSGTDTGGGPCGNAEGNHDLEDVVGAGEDNARSGDRRRQRERETQSLRSCVGGDGEAAG
EARRRRKTMLSEKQATQLKKEGYKLVGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSSQ
CMELTPSLACANKCVFCWRHHKNPVGTSWRWQMDSPDFVVEQGLKNHFAAVKELKGMAEV
NEARLASARAEVRHCALSLVGEPIMYPRIDELVKLLHQQHISTFLVTNAQFPDALRNLPP
VTQLYVSVDAANPKDLKALDQPLFADYWERFVACLELLKEKRQRTVYRLTLVAGYNMDNP
SGSTPDKPDTGENPETRSTPASPPESPQNEAKDRCCRAVASGDTETGHACGCRSPSMLDG
DRAREETRTRGLGRRGEKATQGRAESREGQSLTDRSAAAYAKLVLRGSPDLIEVKAVTYS
GTSKHSKLTMKNIPWHDQVVSFCQALCDALPAGQYAIACEHRHSCCVLIAKTSYRRDGVW
HTWIDYDRFHQLATSGNTAFTGFDYCAPTPSWAVYGSAEAGFSPFEKRVFSKGKQKRLLR
DKDRSGPDADAPNGGN
>A0A0F8ER14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 2.H.T.1A.15|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFYIPDFATLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPSMLAKINPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDFMK
EKSSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISYLD
>A0A2H9RRA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon CG_4_9_14_0_2_um_filter_34_16|TrEMBL
MSCSGETVEEDHLIQIRPAISEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEHVAEPEEILTKLMAERKKLING
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPKLIKYLNSLEATKSIFLVTNGQEP
DMIQRLQDEDALPTQLYLSTNAADYESFMRINKPKYNDSWERWNRTLDMLKDLNTRTVLR
ITLIRNYNDQKEGIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMEEVRKFSE
QVSRQSKIFLIMDESVVSRISILQNNERFIDRFIPTYANTI
>A0A1G4BLI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum orchidophilum|TrEMBL
MASIHEPIGFKSILNNVHDVWQQVRIPVILFTAFGLLILRFYLHSTEEKSELKALPKVYT
REKPETKPVEEKKDVKPSPPSPTVEPNAPKPNGPKRIKGGIVKRNPSSEAKGDAPVRKVR
PLVFFSSITANTPKIAKEYAERLGNGLQKIAAGTDCSFTAPELLDLAEVDFDDYFITPPK
SEEDPADLFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDREG
WPTEEDGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVVDVLGMLAK
TGSLGEGLPGSGAPEESDDESAAEDDDELLIEDSEVKPEKLKSRKNIDDVEDLGRIMKSS
NPDAAMNGPAAKATAAAPIAVDFTTYGKTVAKKAPLNAAKEMVPQNSPTYASLTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPELIFDGVKANHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYC
GTSTASNAGLSMSNVPFYWEVQEFVTALEKRLNEKGLKYGIAAEHAHSCCILLASDRFYV
DGKWHPRIDYQRFFELLEERGPDGDWKPEDYMGEATPEWATWGNGGFDPRDDRVDRKGRK
IEV
>A0A2A5VH56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group II euryarchaeote MED-G36|TrEMBL
MEPAIAARLAKQKYHLVGEHGGVKVCHWTKQSLIANRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLTKIDDDPYELFLESVRAHRRLITGYGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHQHGVSTFLVTNGSLPKVIEQLDPLPTQLYVSVDAP
NKEIFNRLCKPKFDTAAFEKLEETLAILPSLDTRTVCRHTLIKGESLGHFKDYARLDNIA
DPNFIEAKGYVYVGNSRSNHTIENMPSHNEVMEFSHNLAPLVGREVLSERSESRVALIGK
EMIPVVLPEKVRDFPKDLGIAKPQNLVLPQA
>A0A7R8A543|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus kawachii|TrEMBL
MEASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPENRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKRNKNQSVVDLEDIKFNSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAVETQG
>A0A1I6ZI24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina thermophila|TrEMBL
MEEKKRNTGEDFPEVQEKNGGGESTSLPFDIPDFKTLLKKQGYALAGRHSAVKTCLWLRH
AMNGQGSCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDLPEKIVEE
SIACQRKLITGYGGSPNALKERWLEGNEPNNVAISLSGEPTLYPYLPELIEEYEKRGFTT
FLVTNGTVPDMFAKISPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSIMKQKKSR
TVIRTTLVKGENMFKPEAYARLIEKASPDFVEVKAYMHLGFSRLRLDRSAMPTHEEVLEF
SKELAKHLGYKIADESEISRVVLLSKDGNKSPVRNLSFPD
>N1PBB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capitella teleta|TrEMBL
MEQYIRASIVPVVVIAASTLLWLLFQNKKNGINVKVCLQNLRSVRILILKLFQKSYRSRE
IKENKLLVEKEKEARLKFPKKIFILFGSQTGKAKGFAEDLESELKAKRLDVQLINLVGFD
PEDTLASMANPDAAFVFLLSTYTDGIPPEGAQWFCSWLQASASDFRVSKSLLSEVSFAVA
GLGHSLYKLHFCTAARKLDESLSVLGGRRLLAMGELDENVAQSKNGGQEADFNSWKSQLL
TALSSFEDLAPVKIKEAECCGECSCQEKKKVRAEVMNFLVNRVVLYESSDDDDDDNEGED
EEAASKLVDVEDLGHVMTKMKVGFLEKDMNIEYNLCINVKTSNECQRTVIDKRFNHSLKR
LCRWTKSMLRGRGGCYKHAFYGIASHQCMEATPSLACANKCVFCWRHHTNPVGTEWRWQM
DDPEVLINGALQNHTNLIKQFKGVPGVQAERFAEGMAPKHCALSLVGEPIMYPEINRFCE
LLHSKDISSFLVTNAQFPEAIRNLVPVTQLYVSVDASTKDSLKRIDRPLFRDFWERLIDS
LKALSEKGQRTVYRLTLVKSWNTEEIQNYADLVQLGKPDFIEIKGVTYCGESKASTLTMQ
NVPWHQEVVTFVQMLADLLPDYELASEHEHSNCVLLAHTKFRVDGSWWTWIDYEKFHRLV
RDFEESKTPFTAMDYMAPTPSWAVYGAQEQGFDPQEVRHYRKKRKELGGC
>A0A842X096|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MKSPVDSSTITSSRRPSSSPPTVMTGFPPNCLAIMYVTIVHPTCKTIQFIKNPALKTIPM
ISEALRRLLAKQHYSLVGGHSAVKPCLWLKKSLRGEGHCYKQRFYGIESHRCMQMTPAVG
WCTHACVFCWRNTEHTMGVGMDSWEDPEEIVEGCFNAQRQAISGFGGSDGVDMDRFREAQ
EPSHAAISLAGEPTIYPDIGGLIECFKKRAMTTYLVTNGTLPGRLEALDTLPSQLYMSLV
APDRETHRRVCAPLVSDAWDSINSTLELFPSLDTRKVIRLTAVKGWNMLDPQAYARLISR
ANPDFVEVKAFMFVGGSRNRLSMDNMPSHSEVRAFAGELAGELSYEVADEKVESRVALLK
R
>A0A497FVZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MEGFNAYLKLMHDTYKRQGYHFVGVQAVVKPCHWTKKSLISGGREFCYKQKFYGIPSHRC
LQMSPIIQCSQRCLYCWRAQPSDLKISFDELKVKVYDDPYSIVENSVSEWQKILSGYYGN
HKIDPVMLQEAMRPIHAAISLVGEPTMYPRISELIEAFFEYGFKTTFIVTNGNFPEVISS
LEREPSQLYLSLSAPDEETYRKICRPLLKDGWRRVLESLELLKSLSCPTVVRITLVKGLN
TSNIEKYAKLLADAEPTYIEPKAAMSLGYFRHRLDVNSMPRHQEVREFAEKLAEYSGYNI
IDESLSSRIVLLSKLRKPIKLI
>A0A6P7JL48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Parambassis ranga|TrEMBL
MLSLFLVVVLFTSHGSTSDTKVSHDAHTHSENYLMLIWHNRLYLYSAAALVFGIWFSLKV
ALKKKSIAEDVASSSVQKAAKKSTCSDRDAEVYVSGVKIFYGSQTGTAKGFASGLSEEVK
ILGLPAEVIDMKDYDPDDQLADESVSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAMRIMTRGEGDCNVVKSRN
GSIQGDFLAWKVKFLKRLQALAKGEKKSCSGNCKKGGSCKNKKKERQEEEEEEEEKTDVQ
NNSSEEELIDSSSEEEESDLQDEKKVVDMEDLGNIMSSVKKAKESRGNGQMVKLSKLNGV
KKLEDEAERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQFRGV
PGVKPDRYEEGLVVKHCALSLVGEPIMYPEINAFIRLLHSQRISSFLVTNAQFPQEIRSL
VPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVE
EMQSYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYEESGGQQTFSVLDYMAKTPSW
ALFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A7C8KJE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MAEMYKSRSPDLIELWHTIRIPLIIAIGVLYITIRLRSILRARAPVLTTPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPVKPNAGAPPAVEGG
EEITQRNGKSIQVFIFYSSLTGSTAKYADKLSNDLFSEPLHIPKPTPPSVDNAEPEPVVE
KATFLPPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFP
IGMGDVKGDALASMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPSKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYANLVEKGLPAFVEIKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNGALQKRGLGYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTA
EEVAAELAAEAAEAESGCG
>A0A7J6EZP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cannabis sativa|TrEMBL
MSLTSAPARVTLLAALSATTFYFLYKSLRLRSLPYPRTPSSSSPTRKSNKIIFISQTGTS
KTLAHRLLRLLASNSFDFDLVDAKDYEPEDLCNETLVLIIASTWDEGKAPTDSRFFTDWL
AESAEDFRVGSLLLKQCEFAVFGVGSRAYDSTFNAVAKDLSKRMKALGGNEILPVSEGDV
DSEGDVDEVFDDWSLKLVRFLKGDEVVEEENGGFVSDDESVEEEEEEESEIVDLEDIAGK
GPSRKTGAQSNGVSNNSNSNGKKNMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLRG
RGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWNMDDPLQIVNSAI
EQHLKMIKQMKGVPGVTLERLTEGMSPRHCALSLVGEPIMYPEINTLIDELHRRRISTFL
VTNAQFPEKIKDLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALRDKHQRT
VYRLTLVKGWNTEDIDAYFNLFSIGKPDFIEIKGVTYCGTSSTSKLTMENVPWHADVKAF
SEALALKSGGDYEVACEHVHSCCVLLAKTDKFKIDGQWYTWIDYEKFHDLVASGKPFDSK
DYMALTPSWAVYGAQEGGFDPIQLRYKKERNHHKKSTQSTSIPGLRLNTTSPVEEIEDEE
KKILTC
>A0A6U9R5P5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Picocystis salinarum|TrEMBL
MMGLAWAWKASWWTVAAIGQVLPFPFQVVVLATLLALVAEDARTNRKHACFDKDLDAEAL
AETCRNETMETNGRRGVVVYASQRGTAEQLAQTLVQHASENNVVLEMVDAKTTDPEELPR
CEFVFFVASTYTDGKPPDGTQWFFDWMAEAVDDFRVGKGFFNRTRFAVFGCGNSLYEENY
NRVAKQLDRNMENLGGIRMMRLGKGDEDKGMMHADFSKWSTILMQRLQNPQEGIQWDPDS
PTDSSASLGDNSSSEGDTSNSDVDIEDLAGRMPRGKREAGVSDKRESQEKPEMVHPVMRQ
KLTKQGYRIIGTHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGKEWKWQMDDADLIVNQAVSEHVKMIKQMRGVPGVQKVRLEEGMQPRHCAL
SLVGEPIMYPQISKLVKELHKQRISTFLVTNAQFPDAIKNLAPVTQLYVSIDAATRDTLK
AVDRPLFKDFWERFLECLRLLNVKKQRTVYRLTLIAGWNMEDVKNYASLIDIGKPDFIEI
KGVTFCGDSGANSLTMKNVPYHKDVCEYSRAICDLRDQEYQLACEHEHSCCVLLARKDRF
YRDGRWHTWIDYDKFQDLVASGEEFDSTDYMLPTPSWAVFGAKEAGFDPQETRFRKIRRH
RNSEAKL
>A0A1A8JKB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius kuhntae|TrEMBL
MFRLLLFLSHITAHAASSGTNAQQDAPRPGESHLLWVWTNRLYVYSAAALVFGTWFLLKV
TQQEKHTDSAGPSCTSNRDPEVHVSGVKVFFGSQTGTAKGFAEELSEEIEALGITAEVVD
MKNYDPDDRLADECVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAW
KVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVDRIESSSEEDESGLA
DERTSGSVVDVEDLGNIMTSAKKAKSKAENDEGQMVKMNGGKKTEDDGERREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCAL
SLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
KIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEV
KGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKV
DGEWWTWIDYERFQELVVVHEESGGQRAFSASDYMSRTPSWALFGAQEQGFDPADTRFQR
RNKTKDVSGC
>B5DF48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rattus norvegicus|TrEMBL
MGPPLDVWDFSSPLLSLWMNRFYIYMGCALGVTLWFCVQIIIKKQVTRSQEKSVPGAPDS
SLSPQEKHTHVSGVKIFYGSQTGTAKGFAVVLAKAVTSLDLPVAIINLKEYDPDDNLIGE
ITSKNVCAFLVATYTDGRPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYR
SHFNKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQR
GEKKGCGGDCKRGKCESAQHGPGEVRSHPHGELHPGDAEEEEPCESSSEDEHGTKGYQSL
NSVVDVEDLGNIMNPVKREKREKAQPEEKVVVHRNSEKNEDSEARAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILKEAIENHRNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEP
IMYPEINRLLKLLHQHGISTFLVTNAQFPEEIRNLTPVTQLYVSVDASTKDSLKKIDRPL
FKDFWQRFLDSLQALSAKQQRTVYRLTLVKCWNVDELQAYAELVSLGSPDFIEVKGVTYC
GESAASSLTMANVPWHEEVVRFVRELVDLLPDYEIACEHEHSNCLLIGHKKFKIGGEWWT
WIDYSRFQELVLQYEESGGSKTFSSKDYMARTPQWALFGARERGFDPKDTRYQRKNKTKD
ISGC
>M0L4I5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobiforma lacisalsi AJ5|TrEMBL
MSDSADSGVGPGTDATDGDDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIW
YGIESHRCIQMTPVVKCNERCVFCWRDHRGHAYELDDVEWDDPEAVVDASIELQKKLLSG
FGGNDEVPREVFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTNPDV
LRDCEPTQLYVSVDAPERHTFDQVVKAVEDDAWERLLETMDVLAEKDDTRTVLRTTLVKG
ENMHHPDWYAGFYGQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVAEFAREVGEYMPE
FTECKEVPASRVALLSKTSDTWVPKLKKDSEFWERDPVTGTAGD
>A0A3Q1F4D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acanthochromis polyacanthus|TrEMBL
MLSLFVTVLVFTDRVCSSDSRASQDVHSPSENYLMSVWHNRLYVYSAAALLFGVWFSLKM
TLKNKSFSKDAASWVSKAEQKNNNSSDRDAEVHVSGVKIFYGSQTGTAKGFAHELSEEVK
TLGIPAEAIDMKDYDPDDQLADECVSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRN
GSVQADFQAWKVKFVNRLQALARGEKKSCSGNCKTGGSCKNKKKEKQEEERAAAQNNSSE
EELIESSSDEEESSPSDEKKSGSVVDVEDLGNIMNSVKKSKGKGEVQGDGQMVKLSKLNG
VKRVEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQFRG
VPGVKPERYEEGLSVKHCALSLVGEPIMYPEINAFIRLLHFHRISSFLVTNAQFPQEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLGSLRALGEKRQRTVYRLTLVKAWNV
EEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYE
IACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELAKAHEESGGQQSFSAMDYVAKTPS
WALFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A4D6GX97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium salinarum (strain ATCC 33171 / DSM 3754 / JCM 8978 / NBRC 102687 / NCIMB 764 / 91-R6)|TrEMBL
MSESDGPKQVDDPDYHHENHTAAQTCGWTANAMRGEGTCYKHAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHSGHTYELDGVAWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEAM
EPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPAVLRECDPTQLYVSVDAP
ERATFDDVVGATEDDAWERLVDTMDVLHAKDDTRTVLRTTLVGGQNMANPDWYAGFFERA
APDFVELKAYMHVGDSRDRLGRAAMPDHEDVLAFARAVKTHLPHSVLREQPASRVALLAR
DEDTWVEDLRPESAFWTEGARPTAD
>A0A0R0FIC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glycine max|TrEMBL
MSISISLSSVPARLTLLALFSATTFYCLYKSRRLRHLKLSLNPNPNPNPNPKILFLSETG
TAKTLARRLHRLLSSNDVAFDLVDAQHYEPEDLPKETLILLVASTWQDGAAPAASRFFAT
WLADAAADFRAGSLLLSRCRFAVFGVGSRAYGDDSFNAVAKGLAMHLRALGATEAVPLSE
GDIDGGDDVDAVFDRWCEKVVAVLKGVGVVESCDNDGAEECGVVSSSEEESDVESSEIVD
LEDIAGKAPSRRKVVANGEESNGKLNGSREMVTPVIRANLEKQGYKIIGSHSGVKLCRWT
KAQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIE
IVNSAIDLHTNMIKQMKGVPGVTLERLSEGLSPRHCALSLVGEPIMYPEINALVDELHKR
RISTFLVTNAQFPEKIKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALK
EKHQRTVYRLTLVKGWNTEEVDAYSKLFSLGEPDFVEIKGVTYCGSSTTSKLTMDNVPWH
ADVKAFSEALALKSQGEYEVACEHAHSCCVLLAKTNKFKIDGQWYTWIDYEKFHDLVASG
RTFDSRDYMAATPSWSVYGSEEGGFDPGQLRYRKERHHKSTRNQAG
>A0A814AM64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFKSSPKS
PSSKKIIPLEKNGVTIVFGSVKGNSRIFAQSTYDKLSKDLNRQVIIQDFNDVTDPEEFLQ
TQAKNQRTLLVFIPTYEDATPPPSAKWFLLHLQEAATDFRVSKGELEKLTYAIFGCGNSL
YFENFNKVAKEVDRCLSELGAKRLLPTELADENTAKSIYGGQEGHYSKWSSKLKSALETP
KTEKCDCSNDTSTTTCCKTVTNGDHSIKNDDNNNDDDEEEPRIESDDDDEAGGCKDGNDD
IIDLEDMGEYMENSSPTKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAQTVTQG
AIDNHYKMINTFKGVPGVLPARLAEGMKIRHCALSLVGEPIMYPHINELIEILHSKQISS
FLVTNAQFPDEIKTLQPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKGQ
RTVYRLTLVKGFNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASSLTMANVPWHEEVV
TFVQALCERLPQYEVACEHEHSNCLLLANTKFRVDGKWHTWIDYDRFQELVARHKATSGA
ETFTSLEYMAATPDWAVVGANERGFDPSDTRWHRKSTAKKDLSGC
>A0A814MV08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFKSSPKS
PSSKKIIPLEKNGVTIVFGSVKGNSRTFAQSTYDKLSKDLNRQVIIQDFNDVTDPEEFLQ
TQAKNQRTLLVFIPTYEDATPPPSAKWFLLHLQEAATDFRVSKGELEKLTYAIFGCGNSL
YFENFNKVAKEVDRCLSELGAKRLLPTELADENTAKSIYGGQEGHYSKWSSKLKSALETP
KTEKCDCSNDTSTTTCCKTVTNGDHSIKNDDNNNDDDEEEEPRIESDDDDEAGGCKDGND
DIIDLEDMGEYMENSSPTKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAKTVTQ
GAIDNHYKMINTFKGVPGVLPARLAEGMKIRHCALSLVGEPIMYPHINELIEILHSKQIS
SFLVTNAQFPDEIKTLQPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKG
QRTVYRLTLVKGFNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASSLTMANVPWHEEV
VTFVQALCERLPQYEVACEHEHSNCLLLANTKFRVDGKWHTWIDYDRFQELVARHKATSG
AETFTSLEYMAATPDWAVVGANERGFDPSDTRWHRKSTAKKDLSGC
>A0A7S3LYD1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spumella elongata|TrEMBL
MDQNSKRSLIFGLVSLAGVISLTWFLQNKKHFAGGKFPSAASLVWKSENQPVHAGKIVII
YGTTTGTGKTFALKLLSKLQAVGRTAEIVNMKDYDQEKLVKEDIALIIVSTWEGGVAPES
GSAFVEDLRDYAYDFRVSKDLLVKLKYSVFGLGAELYGPNFGKAAVDIDEMLSTLGATAI
APVTLGDDASNLEERFGRWTAQLVNGLSTRLNEPAEEEGVSKRQAKKNKQKKEGNLKKKA
EKGEAQDQYSGTTKYPVKNTKGAKNNTTTNVGYANSGIVSKASASTGCCSTGPESSPKEG
CCGGSGSGSAAKETKSSGGCGCNESAPDSNTLGLDPAYLSEEEEEDRINNNYVTMDHVED
EQDLHQLEQAGLLDLEDMGNAVNQSNASSNGHRQDVKDSLRGDGPDERREMVTKLQRKAL
TKEGYKIIGTHSAVKICRWTKNQLRGRGGCYKHSFYGITSYQCMEATPSLACANKCVFCW
RHHKNPVGTEWRWKEDAPDMIVSEAVRLHQGMINEMRGVPGVQSERLTEAFTVKHCALSL
VGEPIMYPRINEMLSAL
>W7KAJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum (isolate NF54)|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDH
QIFLSTIGNDEKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYN
DTSNTNDTNNTNNTNIMNNTNNTNIMNNTNNTNIMNYTNNIRTGENCVSESETSSNQSYP
DDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCY
KHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKA
MIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQ
FPQELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFT
LVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWN
LINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALD
YSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A842KLQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomethylovorans sp|TrEMBL
MSSQESNLPYLVDLHSLLKKQGYSLAGNHSAVKTCLWLRRALRNEGKCYKASFYGIESHR
CLQMTPTLMCNQRCLHCWRPVEVDVPAPEEWDSPSEIVGSCIKSQRKLISGFGDCEHRNL
WLEGNEPKHVAISLSGEPTIYPYLPELVEEFKEHGLTTFVVSNGTNPEMISRINPSQLYV
SMDAPNEETYYKVCRPQSIHLWSKFNKSLEVLRYKATRKVIRITLIKGINMFHPDGYAEL
IRKASPDYVEVKAYMHLGFSRNRLHREAMPSHDEVMDFSLQIANRIGYTVAEHVEISRVV
LLSRDGFVSHLE
>L0JZE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronococcus occultus SP4|TrEMBL
MSDSADSGTPTNADGDGAPAQVSSPDYHSENHTAAQTCGWTANALRGEGCCYKKVYYGIE
SHRCIQMTPVVKCNERCVFCWRDHQGHAYELGDVEWDDPEAVVDASIRLQKKLLSGFGGN
DEVPREVFEEAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEMLRNC
DPTQLYVSVDAAERHTFDQVVKAVEDDAWDRLLETMHVLSEKEETRTVLRTTLVDGENMH
HPDWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSSMPDHEDVVAFAERVGEYMPEFTEV
KGVPSSRVVLLSKTTDTWVPKLKKDSEFWERDPMTGD
>A0A6J1XYI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acinonyx jubatus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A7J4NSU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MNTLPKHQLDLFKKQGYHIVGSHGAVKPCLWSGRSIKGKGNCYKSQFYDIQSHRCIQMTP
FLGCNQSCLHCWRPVEYPVDTPAEWDSPEEIVGDSIREQRRLMSGYGGLDDADKVKWKES
LDPKHAAISLAGEPTLYPLLPELVREFHKQGLTTFVVTNGTKPDVIEIIRPSQLYMSLDA
PDKETYIHSCAPDHQDQWERILESLEVLSRHPCRIAIRITLTKGLNFKDAAGYARLIKIA
EPDFVEVKAYMHLGYSRKRLERDAMPGHEEILEFTSELGRELGYHMTDDVEPSRVALLSK
EEKVTPVTL
>A0A7K7I1Q2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhegmatorhina hoffmannsi|TrEMBL
LDVSVDMWNYFHTCVASIWLHRFYIYSAVALGISLWIVIQFTTTKAKKKVTEPGEKSSGN
PPSSKGTEAKLRNGCATPQAKEVHVAGVKIFYGSQTGTAKGFAKALAEAVASLNLPVEVI
NMGDYDPDDSLSEETTSRSVCVFLVATYTDGQPPEGSAWFCKWLEEAASDFRFGNTYLKG
LRYAVFGLGNSVYVDHYNTVGRSIDRWLWVLGASRVMTRAEGDCNVAQSRHGSIEADFAA
WKTKFLSRLQALCRGEKKPCSGRCKKGKCKSPGKQSKESSDHEHEASEHENTEAEELFET
SSEEEGGAEEAGGTNSVIDVEDLGNIMGHMKKAKVLLLQWVWNGQGLDCLKYHFLGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVLAARLEEALVVKHCALSLVGEPIMYP
QINRFVRLLHQHSISSFLVTNAQFPEEIRALEPVTQLYVSVDASTRDSLRRIDRPLFKDF
WQRFLDSLKALAEKRQRTVYRLTLVKAWNVEELRAYAELISLGKPDFIEVKVRLLYFFHQ
YFPFFPPPHFPLSLVLNFLSNLPWHRSGFGVPITPCPLFSLQFKVGGEWHTWIDYERFQE
LVQEHQHSGGSRSFSAADYTARTPAWALFGAKERGFDPLDVRHQRRSKARDLSGC
>D3DZJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)|TrEMBL
MTFTKEEQAKLEYSGYRFVGEHGHAAAKTCHWTRKSIKNEGVCYKEQFYGVKSHRCLQMS
PAVPFCHQKCSFCWRDLSQTRTEWEGEYDDPKTIIEGAIKAQNNLLCGFGGNKKADRKKL
EESKRPTNAAISLAGEPTLYPEIDELIGEFHRQDFTTFLVSNGMYWEKLGSLENEPTQLY
VSLDAPNEKVYNELCNPQIDDGWGKLNKTLELMPSFKNNTAIRITSVKGKNMFNTDEYAE
LINKADPTYVEVKAYMFVGSSRKRLSMDNMPRFHEVNDFAKEIADKTGRELTKYSEASRV
VLLE
>A0A8B9ZD71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Buteo japonicus|TrEMBL
MDTWNFYTCLVSLWLHRFYIYSAVAFGIKDPKNLLVNGYATLQAKEVYVAGVKIFYGSQT
GTAKRFAKGLAEAVISLSLPVEVISMGDYDPDDCLSEETTSRNICVFLVATYTDGQPTES
AVWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRI
MTRAERDCNVAQSKHGSIEADFEAWKAKFLSRLQALCRGEKKPCSGKCKKGKCKSLGKQS
KESSDHEHGASEYENTEAEELFETSSDEEADGEEAGGTNSVIDVEDLGSIMSHMKKAKRE
RELAEGDTGTSLTHKNAGRKEEGEKREMITPALREALTKQGYKLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQ
EAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINQFVKLLHQHSIS
SFLVTNAQFPDEIRNLGPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQ
QRTVYRLTLVKAWNVDELKAYADLISLGEPDFIEVKGVTYCGESSASNLTMANVPWHEEV
VRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKINGEWWTWINYDRFQELVREHERSSG
SKTFTAADYAARTPHWALFGSRERGFDPLDVRYQRKNKTRDISGC
>A0A2E0QIR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGEFVEKEPELIQIKPNIAQQLKKAKYGVADHSTVELCHWTKKSFRNEGTCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDEXKVAEPKDIMSKLMEERRKLIV
GHFGDPNQDKQKIEESLTPHHYAISLSGEPTMYPKLPDLIKYLKSLETTKSIFLVTNGQE
PEMIQRLADEDALPTQLYLSTNASDYDSFLKINRPKYDDSWERWNETLEMLAGLDTRTVL
RVTLIKDWNDSEKMMSGYRSIFEKSNVXFIEXKSYMHIGRSTXRLEYENMVXMXDVRXXS
EXIXKXSDRFEXMDXSEXSXIVVXQXKKRXTXRYLSAYA
>A0A062V782|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedens nitroreducens|TrEMBL
MTLRYESTRELLKKHGYHLAGTHSAVKTCLWLNKSLRNEGSCYKSRFYGIASHRCIQMTP
TLLCNHRCLHCWRAIEVQAEAPESWDSPEDIVDSILIEQRRLVSGYGGSEIMDKAKWKEA
FAPKHVAISLSGEPTLYPYLPGLIDEFHKKEMTTFVVTNGTNPEVIGDIRPTQLYISLNA
PDKEIYKRACGPLDDTWERINQSLEVMRDSRARTAIRITLIRGVNMVDPDGFAHLIETAE
PDYVELKAYMHLGFSRKRLSLDSMPSHQEVMDFSQKVAEALDYRITDDSEASRVVLLSLN
PECYDK
>A0A2A5VRI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group II euryarchaeote MED-G34|TrEMBL
MEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLVNDRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLHKIDDDPYELFLESVRGHRRLITGYGGNPKADPEKFREAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPDFIEAKGYVYVGNSRNNLTIENMPSHDDVMGFSHRLAPLVGREVLSERSESRVALIGK
EMVPITLPEKVRELPKDLGIAKPQKYVLPQT
>A0A830G7V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halarchaeum nitratireducens|TrEMBL
MPEQVDSPSYHHENHTAAQTCGWTANALRGEGTCYKHAWYGIRSHRCIQMTPVVRCNERC
VFCWRDHNGHAYELDGVEWDDPEAVVDASIDLQKRLLSGFGGNENVPRERFEEALDPKHV
AISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEVLRECDPTQLYVSVDAPERATF
DDVVGATEDDAWESLIDTLDVLAEKEATRTVLRTTLVNGENMTNPDWYAGLYRRADPDFV
ELKAYMHVGHSRGRLDRDSMPSPETVESFARRVGEHMPEHPVVKVQEASSVALLARDEET
WVPALAPGGGFYD
>A0A3P8V9H8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cynoglossus semilaevis|TrEMBL
WVTSKFNHVIGKESEASLTLGFPLASQNEYSITETYFMSIWNKRLYLYTLAALVFGAWFL
LKALWKKVSLPTSQTRIKSLKNVDSGVYKAVKNNEQPHTDKVVHVSGVKIFYGSQTGTAK
VFAQELSEEVKTLGITSDVIDMKDYDPDDRLADECTSKSVCVFLVATYTDGEPTENAEWF
CKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRG
EGDCNVVKSRNGSIQADFLAWKAKFLNRLQSLAKGEKKKCSGDCKTNGSCKKKNRKEDQV
VEKQQQVEEKTSSEEELMESSSDEDETGGKSGSVVDMEDLGNMMSSVRKVKVSLHHTLRY
LVYRSVEHFHCSFTSFFTGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEEILQDAMEKHQNMIRQFRGVPGVKPE
RYEEGLVVKHCALSLVGEPIMYPEINTFLRLLHSHNISSFLVTNAQFPEEIRSLVPVTQL
YVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEELQAYS
ELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVSFVQQLADMLPQYEIACEHEH
SNCLLIAHTKFKVDGEWWTWIDYERFQELVQIYEESGGQRSFSALDYVSKTPLWALFGAQ
EQGFDPDDTRFQRRSKTKDISGC
>A0A3A5WBE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVKSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNSNAWDKFSETLDLLPSLDTRIVCRHTLMKGINMSKQHVKEFAALDM
RADPDYIENKGYVFVGHSRENLGVENMPSHEDIMEFSNAIAPLTQREVLSDSRPSRVALV
GREITPIPIPQPTMFFPDDLGIAPSVKHLQMANV
>A0A7M3ZT06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPMDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKAVFDAVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDAHIEQFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARKVLSDSRPSRVALV
GTEITPLPIPEPTMFFPDDLGIAPPVKHLPVVS
>A0A2I1GAZ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis|TrEMBL
MLLRYFESLYLSYQALFWSCLAVGGIVVFYVTLLNSKKKKKQIIEDNKKIRELSAVNKEK
TTGKGLRKRFTRSTKKTSNQTCTNDSGEKSACCGNGGVSDCCKNQLSEETSHIITANKST
KISVKIFYATQTRTAKYFAQQLYQSFTKHSNCECSIMDIVEYETEDFLSESAICIFLIST
YNVEGPLDWFYKWLEDTRYDFRVDKQALSKMKFAIFGLGDSAYGDQFCIQPRNIDKWLGQ
LGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDPSYALNNVSSNLNYDSYSESDSDSD
NNNNSDTEMVDVEDIGALAPKLQAARKSKEKEEFVYKNSNGRPKRTLSEQEVPINEPKEM
VTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSHRCLETTPSLA
CSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLSNHYKMINEMKGIPGIRADRFQEAF
NVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMVCNAQHPSRLRALDKVTQLYVSVDA
STKESLKKIDRPLFKDFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEIANYVELVRRG
KPDFIEVKGVTYCGFGGASKLTMANVPYHNEVISFVKHLNENLGDTYEIATEHSHSCSIL
IANTKFKINNKWYTWIDYDKFFELLEKGEHFTSLDYIAPTPSWALFGSPEAGFNPEDQRF
YRKSKKINNSVKNGGC
>A0A1X2HQ39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Syncephalastrum racemosum|TrEMBL
MNNVVNSILSGFSSILALDQGFTGTADDGCACSSGGGSGGCCKDQPKKEEENKIDTSCAC
GSETPCNDGPTQIDTVKLVYASLTGTAKTFATELENKLKQQTNIRIQHLNVVDITEYDND
DLLTETAVCVFILSSYNVEGPLDWFTKWLRDLRYDWRVDRLALQKLRYAVCGLGDSAYGD
EFNQAAQSIDKWLGQLGATRIYPLGACDKNNDQKAQFDSWADLFMAELHDKRSLEFAPAQ
IEYDSDAEEEQEEETNKDVMGSGDEMLDVEDMGKMASKLRAAKQNREEEELDFERSHAKR
SIGEAPKKKTSSEPRDMVSPMLHKNLTKQGYKIVGTHSGVKICRWTKAALRGRGFCYKHS
FYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIK
QLKGVPGVKADRFQEAFTIKHCALSLVGEPIFYPHINEFVNLLHENNISSFLVTNAQFPD
KIADMVPCTQLYVSIDAGTREGLKKIDRPLFRDFWERFLGSLESLSKKGQRTVYRLTLVK
DHNTDEIDNYVELVRRGKPSFIEVKGVTYCGYSGASNLTMANVPYHHEVVDFCQKLVDKL
GGGYAISAEHAHSCSILIASTDFYVNGEWYTHIDYPKFFELVRSKQPFTAKDFMAKTPAW
AVFGAPEGGFDPDETRFYRKGKKPQEQKTLEVAAAS
>A0A0M0BUU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|miscellaneous Crenarchaeota group-1 archaeon SG8-32-3|TrEMBL
MLEQSIPLPLLQVLKKHKYHLVGKHSAVKRCNWLYESLIHGRSCYKQKFYGIKSHQCIQM
SPSLFYCTEKCLFCWRAQSGDLQIKWNEMKLPNWDPAEEIVQESLKAQTKILSGYNGNPK
TNWKKFAEALTPKHVAISLAGEPALYEHLGELIGLFHHKGFTTFLVSNGTIPSKLAELSE
EPTQLYISVCAPNEEVFKRVCRPQVPNAWAKLNETLSMLPNFRCPTVTRMTLVKGHNMEH
IDGYADLAERAEPTYIEAKAYMHVGFSGLRLDYKNMPSHKEVHAFARRLAEKTGYKILDE
AVESRVVLLSKRRKPLRFDTP
>A0A424QKE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED117|TrEMBL
MDPGLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVTPEKFKEAQNP
KHVAISLNGEPTLYTKLGEYMELCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDEVCRPKWGNGAWDQFEKTIDLLPSLDTRIVCRHTMMKGINMSSEHIKQFAALDN
RADPDWIEAKGYVYVGHSRENLSMENMPSHEDILNFSNELAPQVDRRVLSESRPSRVALI
GREIVPIPLPDPEMFFPEDLGIAPPTKKLPLIQN
>W2RYV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyphellophora europaea CBS 101466|TrEMBL
MDIGEGGAWPVVAADYIDRALTFWHEHRIFLAGCLVATIITLGVLRRQRVPKHVRQDSPS
AAEKASWLSEEKWSAEASRGTLVAGTSRAATKPTAARIVAGRKPIPRAGSETQNEESALQ
PLVFFCSLTGTAERLSKEVAASIEMLSQSNDSVRKPVVLDLAYVDLDDYFISGPKNASAE
KALKYFYILLIPSYDIDTIITNFLAHLDETHNDFRIDTSPLSPLAGYSVFGIGDKEGWPS
EEEGFCSHAIDTDRWLAKLTGRKRAYPLGLGDVKSNLDQCLGDWCSGLSSALTDLTSTGY
LGEGVPGSGDPEESDVEDAAEFPDNNRRKRQKTSRKATTTDLEDVGGRSNSNSASGTSTP
LTIDFTTYSSANGPTTQSQALKAMVPKESPTYAALTKQGYTIVGTHSGVKICRWTKSALR
GRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVATTWRWEVDDPHAIFTGA
LEGHYKKIKMMRGVPGVRAERFAEAMRVRHCALSLVGEPIFYPRINEFVDLLHGDRISSF
LVCNAQHPAQLRALKRVTQLYVSIDASNRESLRRIDRPLHRDFWERFVACLDILRERRFE
QRTVFRLTLVKGFNVEEEVEGYADLVARGLPCFVEIKGVTYCGTSSAAGAGLTMQNVPFY
EEVVAFAEALDRALLKRGLAYGIAAEHAHSCCILLASRRFEVNGRWNTVIDYDRFFKLLE
AGEDFKPEDYCSETAEWALWGNGGFDPRDERVDRKGRPKEVKAKEVLGEESVKPKKQPQA
SIDF
>A0A6J1K9S7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cucurbita maxima|TrEMBL
MSFSSRSAKLALLALLSASTLYCFYKSRRLRKLKLSLNPTGCSRRPKLFFISQTGTSKAL
AHRLLNVLNSNELAFDIVDPKDFEPEDLFKEALVLFVASTWEDGGPPPHAKFLANWLSES
AEDFRVGSLLLSQCKFAVFGVGSRAYGETFNAVARDFSKRMKALGAKEILAVGEGDVDGG
DIDKCFDDWSRQLLKVLKVDAVGTGADLYSGIDEDFDAESVEEDDEDADPGEEDIVDLED
IAGKGPSRKSTNVVETNGKLNGKKVMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPLDIVNSA
IDLHTKMIKQMKGVPGVTQEKLEEGLSPRHCALSLVGEPIMYPEINTLVDELHRRRISTF
LVTNAQFPDKIKSLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKALNDKQQR
TVYRLTLVKGWNTEDIDAYSNLFSLGKPDFVEIKGVTYCGSSNTSKLTMENVPWHSDVKS
FSEALAAKSQGEYEVACEHVHSCCVLLAKTDKFRVDGQWFTWIDYEKFHDLVASGKPFDS
KDYMAPTPSWAVYGADEGGFDPVQSRYRKERHHRPKPTS
>A0A7K8WGR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sclerurus mexicanus|TrEMBL
LGVSMDMWNHFHTCVASIWLHRFYIYSAVALGISLWIVIQFTIRTKKKVGEALLQKLGEA
KLGNGCATSQAKEVYVAGVKIFYGSQTGTAKGFAKTLAEAVTALNLPVQVINMGDYDPDD
CLSEETTSRSICVFLVATYTDGRPTESAAWFCRWLEEAANDFRFGKTHLKGLRYAVFGLG
NSVYVDHYNTVGRRIDRWLWVLGASRVMTRAEGDCNVAQSRHGSIEADFGAWKTKFLGRL
QALCRGEKKPCSGRCKKGKCKSPGKQSKESSDHERGASEHENTEAEELFETSSEEEADLE
EAGGTNSVVDVEDLGNIMGHMKKAKRERELQEGSAGMMRESTGRKEEGEKREMITPALRD
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWQWKMDQPEMILQEAIENHQNMIKQFKGVSGVQAGRFEEALEVKHCAL
SLVGEPIMYPHINRFVKLLHQHSISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKESLR
RIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELRAYADLISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVGFVQELAELLPDYEIACEHEHSNCLLVAHTKFKV
DGKWHTWIDYERFQALVREHERSGGSRTFSAADYMARTPPWALFGARERGFDPLDVRYQR
RNKARDISGC
>A0A8J5HFT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zingiber officinale|TrEMBL
MVVAGDLPLPNPGAPSARAASPANPSAKEEGEISSGENAELPTIIAAFNNKEISEPILVS
SRNKLVRYSSTGKVYLYNNVPRLKHSCWFCKALIRRDLQFTLYDLEPWFLFFGRFPGHTS
LVPNTKFHTSNKKYYSKTLKTKQIPFKSSNNRTLSWHKKVSDDNLVIRFSDDDSGTDSGD
SKSVASIEKNDHAARLLKFKMPITSSHRQEMLQQSTLHDEGFMSKKGVPGPAFSNIGKTN
GSNFGNQISSSDKVEDIQKQIAALKTSIRQVNGNFQDTSLADTAAESLRHKISPRENECK
VQTKTIFESVDIVTGSTNNGFEQLNQKLDNQAIHNDGAKAANAKRLPLGVRPTKRLKVGR
PLEPVHASDDALRFQKYSNTHLEGSHQPLLKGQSGFFAVRSGLNCDETKKTLSLSNEGID
RKHGQVHENAAICFKAPHIGAKETILPLSCATLSPYSDPDMNSKQEAKNDITADASCSYV
KSAMGPVLLASDVLDQSSYLAQQVTGVEERVPEWGIFSLESLLELEQSQDRELEEAQEFR
RRCELKESLALKAYRKAQKDLINANKKCAILYRNRETITAKLQTLMLEPSNSVWQSSKQG
HAERIHSKFGYHVPAEGQTSEVLYDKNHGLLNEASLDVSLRMMNKHGSCSNQYSEHDDNT
SDHREKNATNGLSIPASFPNMSTDDDKENLVFDKRDVESNLACSPNVENHAEGIYDLDTK
KEGNSHDYDLEAVLRSKLVAKFGMKTFCKNDDMSSVPCQVHHAVNNNKKRSNTSVNQQIQ
QQTIIQICNSEGAILQHELQPTAERSFKFSCRYASICADPARVEGIMKLSSVKHCDQSQR
NEFSSEVEAQKTDNPKEGSSFLKVSHWLICRSILSPSSSILHNVLPLVKFSVFSYHNRDT
EEKGAWPVHESQKVFCKPDKIDAYTRESDSYFHTLTAEMLQNGLEPTHGFSKDFLPIPAY
YIGASLVKVESHFYHSVLARSMWKYWQPGFSASFAIPFSFQRILPQDAPFLQIGDGAMVD
YDNWSSQSWYLQSHNAKTVLHLAMQIHQHIMKRIIQGLPDSDQSLELALSLFCGKFYKSE
KKKAFAILSRAIESDPSSTILWVVYLHIFYMKEKGIGKDDMLLHAVQHNSSSYELWLMYV
NSRVKLDDRLNAYNNALRTLCQVKLTCDKKKRSRSAHVLDIFLQMVDCLRMCGNVDKAVQ
RICQLVSSSDSDLSSDSMLPELLSFLTVPDKCIFLICCIYVVMYKKLPQEVVHNFESEKD
FPFSIEWPLIQLTIEETNMVGNLMKFAIGKVGLDADAAPQRSDRTALRSLHFLAVSHVRL
SAILYGLQHSEELLVKYVELYPTCLELLLFKVRSQGNCKFDAFWQGFQEILDIWPAEVPG
IQCLWNQCLEHALLQGNDCAEKLIAQWFQQFGELNNPQFRILCDENVGLCRSSKQQLVVE
STDNHTEVDEKMFALLNLSLHRLSNNDVERAFSAVDEALKLCSAKYYGHCLREHTAMSLL
KESEFQSNTRLTMLCLLRNYVADTRFFSTQELLSRQYYKTIRKPRIRHLIDEIMGSVSGD
FSLINSVLEVCYGPTFLPETIESKELVDFVETLMALTPANYQLALSVYRFTTRNFCDSGT
AYDGIIFWASSILVNSIFQAVPAAPENVWIEAADLLGNSVAKEVAERFYQQALSVYPFSL
KLWKSYFDLAKLMGKTDAQRRRAIRFRSGRGAPGGGTRWVGSDEPVQHERGRDYGVQAEH
QRREAAGAGGEAGGGLLLGAEAGQPDVPVLVQELRPAALLGHRSKAGDAAPSQVQHRSSP
AMLIRSRFGCPDRAFASCLYLFFFVELSNVSLSRRCRLQPSASSLKPTNPSPRGKILYAS
ATGTSRSLAGRLSARLRSHGLPFDLVDPRRYEPEDLPKENVVLIVASTWEDGRPPHDAQF
LSRWLAESAADFRVGSLLLARCRFAVFGVGSRSYGDSFNAAAKDFSKWMRALGASEMAPL
WEGDMDSGDVDDVFELWCRKIVGLLKGDSVAEDGHFDSMAESNGLEVSDEDFDEETEVED
LESAVVDMEDIAGKAPSRKLAVALTNGRENGVRDMVTPVIRTNLEKQVYAVKLTSFAFTL
ICMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDNPLEIVDAVVSEHTKMIKQMKGVPG
VKTERLSEGLSPRHCALSLVGEPIMYPEINALVDELHRRHISTFLVTNAQFPDRIMMLKP
ITQLYVSVDAATKDSLKAIDRPLFGDFWERFLICCRLGCNGEGFCKLARWDWVLKCCGVL
HRRLLLIYIGFCRLTFEQDSLKALRDKEQRTVYRLTLVKGWNAEDLDAYANLLSVGKPDL
IEIKGVTYCGSSATSKLTMDNVPWHSDVKAFSEALASKSSGEYEVACEHAHSCCVLLAKV
DRFKINGEWHTWIDYERFHELVVSGKPFRTEDYMARTPSWAIYGAEEGGFDPYQSRYKKE
RRHGTASLRN
>A0A842M621|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriaceae archaeon|TrEMBL
MFISKFEKLKRLERMGYRFVGKNAHTAVKTCLWTKKSILDEGTCYKQKFYGIKSHRCLQM
SPSVFFCQQKCLFCWRDLRYTKTEWDGDYDEPADIVDECINAQRSLLCGFFGNEKANKEK
LIEAQEPNNAAISLAGEPLLYPMINELIKEFHKRKFTTFLVTNGINYKALESLSEEPTQL
YISLDAPSKKIHKKLCRPQTENAWEHLNRSLELLPTFNCRKVLRITAVNRKNMTKPSAYA
SLIKKAQPDFVEVKAYMYLGYSRQRLEMENMPLFFEVYEFADKIAKLANMDIIDKSNESR
VVLLG
>A0A1Z9NHG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED215|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFYKLEETLELLPSLDTRTVCRHTLIKHESMGYHDDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEVLEFSQKLAPMVGREVLSDRRESRVALIGK
EMIPVELPVANTELPKDLGIAKPQRFLLPQA
>A0A832RS08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriales archaeon|TrEMBL
MSKSEKFKRLEKMGYRFVGKHAHTAVKTCLWTKKSILDEGTCYKQKFYGIKSHRCLQMSP
SIFFCQQRCLFCWRDLKYTRTEWDGDYDKPADIIDECINAQRTLLCGFFGNEKANKKKLL
EAQEPNNAAISLAGEPLLYPMINEMIKEFHKRKFTTFLVTNGINYKALENLSEEPTQLYI
SLDAPSEEIYNKICRPQTENAWEHLNRSLELLPSFNCRRVLRITAVHGKNMTNPRDYASL
IKKAQPDFVEVKAYMYLGYSRQRLEMENMPLFFEVYEFADKIAELTEMDIINKSKESRVV
LLGQS
>A0A443QE87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dinothrombium tinctorium|TrEMBL
SGARCCEQANDECVILFCTQTGNAKRIAEGLQQSLSADQKFCKQTRLFNIKHFDPDDNFT
RFSNSCCNRITLIIIISTYIDGQSPDDGKWFCKWLQEAAHDFRVDKNLLNKIHFAIFGLG
NSEYNDNFCLIAKQIESWFIKLNAIKLIDTGCGDETSFMSLDEQFALWRSKLLNKFINSN
NERHETQTMVNDVRESESDVESPNENLVDIEDLMISRKIKENSDGKAKKEMITPQLRKEL
TKQGYKLIGTHSGVKMCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWKWEMDPPEMIVEEAIKNHCKMIKEFKGVPGVLPERFEEGLQIKHCALSL
VGEPIMYPQINKIIRFLHERKISTFLVTNAQFPQAIQELDPVTQLYVSVDASSKESLKRI
DRPLFKDFWQRFLDSLKALSSKRQRTVYRLTLVKSWNNEELEGYAKLISIGKPDFIEIKG
VTYCGSSKGSNLTMNNVPWHEEVVNFVKLLTNYIDSDYEIASEHEHSNCVLVANKRFKVD
GQWKTWIDYEKFHDLIKKFYETGETFEATDYMTDLPDWAVYGSNEQGFDPKESRFRRKEK
SS
>A0A8B8JJ35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Abrus precatorius|TrEMBL
MSISMSLSSVPARLTLLALFSATTFYCIYKSRRLRHLKFSLYPNTNTKPNPKPKILFLSE
TGTSKALACRLHRLLASNDIAFDLVDSQHYEPEDLPKETLLLLIASTWQDGKPPSASRFF
VTWLADSANDFRAGSLLLSRCKFAVFGVGSRAYGDSFNTVARVLAKHMRALGAAEVLPLW
EGDVDGADVDAVFDLWCEKVVGVLKGGAVDNGGDDAGECGVSSSEEDSDVESEVESEIVD
LEDIAGKAPSRKSVATGEETNGKLNGTREMVTPVIRANLEKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKIDDPIEI
VNSAIDLHTNMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINSLVDELHKRR
ISTFLVTNAQFPEKIQLLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIGSLTSLRD
KHQRTVYRLTLVKGWNTEDVDAYSKLFSLGEPDFVEIKGVTYCGSSATSKLTMENVPWHT
DVKAFSEALALKSQGEYEVACEHAHSCCVLLAKTKKFKIDGKWYTWIDYEKFHDLVASGR
NFDSRDYMTATPSWAVYGSEEGGFDPGHLRYRKERHHKSSRRNQSGSN
>A0A8D3BFT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MLNFLLVVLLFLTPVSTSDIEVSQDEHSPGESYFLSVWHNRLYLYSAAALVFGIWFSLKM
ALKKKSFSEDVGPLVYKAVTNSDRSDRDTVVHVSGVRIFFGSQTGTAKGFANELSEEVKT
LGIPAEVTDMRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNG
SIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEEDLME
SSSDEDESGLQDEKKSGSVVDMEDLGNIINIAKKAKSKEEGGGGGQVVKLSKMNGVKKIE
DEGEKREMITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVK
PERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVT
QLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQA
YSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEH
EHSNCLLIAHTKCEEKTDLHNSDEPPDLHQRFEDLQITAGLFPAFRSCQQNERNRKTTCY
CKIRAHASFNPSLSHLLQTTRGNLPLFQLSAAECWESRGHVLHHPAMVWKTGRMREAE
>A0A8D3C5S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
MALKKKSFSEDVGPLVYKAVTNSDRSDRDTVVHVSGVRIFFGSQTGTAKGFANELSEEVK
TLGIPAEVTDMRDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTFLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSIQADFLAWKVKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEVMTW
DDPLIKYQNFKTVKTITAISQIWIKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSL
ACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVKPERYEEG
LAVKHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVTQLYVSVD
ASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAL
GQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEHEHSNCLL
IAHTKFKVAGEWWTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPGWALFGACEQGFD
PADMRFKRRNKAKDISGC
>A0A8B6FYW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilus galloprovincialis|TrEMBL
MLEKLLSSYIFESFQIPVWTLLLATICLIWMWNSGRKNENSSEKVEDQKSTELPITNENV
IELHANSRQKITKKRKIKIFFGTQTGNAKMLADNLCREATERGHEAEVLDLKTYDPEDNL
VTEGENGVWVVLFISTYTDGTPPEGSEWFCKWLEESSTDFRIPKALLKELHYAVFGLGNS
LYTENYNAVGKKVDRFFRELSAKPILPVGLGDENVAESLKGGMEKDFTAWKKEFWKKSKK
VKDNDTVVTDTCGTGKKTCDGKCKCKEDGGKCSSEEEEEEEEGEDLYETTTEEEDNAEEL
LNEDGDGSSLQTTNGVVDLEDLGKVMQTMKKAKVRRKKEESAQSTGEPREMVTPMLKKAL
EKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDDANTVFQGALDNHVGLIKQFKGVPGVKAERFAEGLEPQHCALSL
VGEPIMYPEINKFIELLHGKGISSFLVTNAQFPDAISNLVPVTQLYVSIDASTKESLKKI
DRPLFKDFWERFIESLKALSAKRQRTVYRLTLVKAWNTDELDNYADLVSLGKPDFIEIKG
VTYCGESKASSLTMQNVPWHEEVVHFVKQLTDRLDDYEIASEHEHSNCILIANTKFKVDG
EWWTWIDYPKFHQLIKGFNESQKTFSAEDYMAKTPSWAVFGAKEQGFDPVETRFFRKKQK
DIGGC
>A0A135S093|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum simmondsii|TrEMBL
MASTLEPVGFRSMLNNVHDVWQQVRIPVILFTAFGLLILRFYLHSIEEKSELKALPKAYN
REKPETKPVEETKKKDVKPSPPSPTVESKAPKSNGPKRIKGGIVKRTSSNDAKGEALVRK
VRPLVFFSSITANTPKIAKEYAEGLEKELQKVAAETDCSFMTPEVLDLAEVDFDDYFITP
PKSEEDPADLFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDR
EGWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVVDVLGML
AKTGSLGEGLPGSGAPEESDDESAAEDDDEVLIEDSEAKPEKLKSRKNIDDVEDLGRIMK
SSNPDAATNGRAAKSTTATAGAAAPIAVDFTTYGKTVTKKTPLNAAKEMVPKNSPTYASL
TKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCW
RHGTNPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSL
VGEPIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKI
DRPLHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVE
IKGVTYCGTSTASNAGLSMSNVPFYWEVQEFVTALEKRLNEKGLKYGIAAEHAHSCCVLL
ASDRFYKDGKWHPRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGKGGFDPRDDR
VDRKGRKIEA
>A0A4Q4R6A7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria gaisen|TrEMBL
MSKSASIPQSARVQKVCTLWTHDDNFSRDEIVFNGEKFPELPTSAGALLQIVAIHTDNAV
RDFYTESKVDTLHNDANGDSHSKRHRRDSITITIDENGSTIPEGRHVDADKAYVFVPKAL
PATMESKYPNLQVSISERIAKVFGFRNRMQVVVTEADEDAHEAHHVEIVFRDEYLARADM
WRMAIAELSKRTVYRGQRLLFMGTIKATIKHIYINGQSVHSGYFSPKSKPIFRSESARYT
LFIQMSREMWDFDTEGAGEIMFNKVVSGFLPDLFKRWLRINARHLVTIILFTRMQYDGEL
LADRPEGTTSNTYADSHSGTFRDYYRVVVSDMASGDWINILYQLKKEFRMFLREVSLVRK
PVKHVNEETGSEDPATDVVVAGRPSSASQGNILEAINLAAAQFAKDYIDRDLVRTGISVI
VVTPGTGVFEVDYNMLKLTTDTLIGSGIGIDLVCLSPMPLHSVPLFKYQTPRSVSDLKAE
HDREQHASPRMSRTEEDKTPRQSQPDFGSMSRASTVRHIPMDVSTDSSDGWRFAMPYWVD
VSFWSGTSEEILELTKPRKADKIIKKSRKKGRIFSLRCRLYELQMMGVMENEVGDIAIPY
LEEDPMYPHHLRELFEPNGEGPQIAPATKPSAAAAGSYSSRGDKEYNEDQLDETRAAQMA
WMEAYDGGVFSPLIERHSALDQLQARKRRLSDEITSGSPDLSRSLRLSSSFRSTGPSFGK
TARPPPDTNFPQLMRERSKDIESQSPRGSTYRMPNLKSEGMPRADVLRRQNNMSRDNASA
GRPTVHKRGGSGDSQDHRQTVNSTQRHPPAPATSRGSSPRRTGLLPISAGTPAPAKQDLK
SRPSNWFLRQMSFGGKAAPAKPTLGDATIDISQGKVKPAMLTVEKNQKGAIAERLASTRH
TSTGKPSQPIAIKPASRAGPTSAESLASDRASRSVETVRVARSDRSNMPSQPGSVVRDPG
STFLLAGARGAGEHGGPKPDLSSSGGGREAPRTLSPTSAIAPWAVLVNPCNPKKNIISSK
NQYRRWHHVFPRTLRTGTVKWRSLCSPAAVPLTHEWFPSVDQIASEYNESPYKITQNEDD
DILEAPKSRESLIKELIAFRLSHGFQIIVGSSVAEFSGRQEKTLASILDPEYMSSDGDTV
FMSVGNSIHQLVCVAGGEVEVRRYNRKPTTALESSAGIDTPFSYKPFIRTAFEDTYDPRE
VVLRPPRREYNWNIIDTFLAGYHDEFSEILRFWRARFVLIPVDIPAMHRRPLPMQDSPEE
IRLEGIRKLTQLWQKFRYIPPEERYFQPASILKQKDPNPLAIEYHTRDPSAVVAAGPDHS
LLNDTDSEFQTSIFSDAEKYHTSSIDIKKLAEDLQGEKGIQMLDRRWHLKLHYNCFLGFD
LTNWLLSNFKDIETRDEAVDFGNELMKKGLFQHVQGRHHFRDGNFFFQIAAEHRAPRVES
RTGWFGMRKTDKSVPSTPLAEAPRTSPLLSKHTKSRPDTADSSSNSSGSVEEGEKTPTRG
EPHKRKVVMSRVMRYDVDPRKRSYRPEIISLHYDRLHNPDNCYHIRIDWMNVTAKLIEDA
IVTWATSVEKYGLKLVEVPIAEVADIVDNHPFRSPYVVKLALQPPQAQPEAMWDSTSFSP
QYPKTDKFAYHKLLLRRLNFVLDMEAASAFPSDVEVTYSWGTPDYKYTQFIHKSGGLLAQ
ISDDGNLLLLANRLAHNRAKDHSRIRPVDPYEHKKATTDGSQSSRLPSTPAVERGNPHRS
PFASPLARPVQDSSLLHTALTFHDPRSAATTPAAASSVPLTPEQVKDEVEAFCSNASLLS
AFYAEAFRHAPSPSPRILPIGEDKIPSLGLPPAISIRDASPATGGWTLSSTFGGPGGIAG
RRQGSEGSMYSMGKRGSVVEGMERAPRRQNSQGSAGTGTKWLLATGMHSNPTNGPHASGL
PKVRTQTRRRRNVESSAMALLELLEQLPAELLFIWHQHRLPILLAALVVATVVRLAIYSR
DRREKLSLSPAPSSPVPVEEKPTVQLKPEWLPEYTTLNSSELNVDNHAEDDTLAVAAAAK
VKKGPKMVKGRKTPKKIVAPATFNHQTDRIQPLVFFQSLSGTTERYAKQFAGVLTEWTRG
CDQSKSFLEPQTLDISYIEHDDYFISPPKGDANVKYFYIILVPTYNIDTVLDVFVESLQE
THNDFRIDTAPLSGLVGYTVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLG
MADVKSEAEERLQDWRVGVQDALVEIAEGRGLGEGVPGSGDPIESDEEDMAEENGQSTRV
DDVEDLGSMVNSSAGPIPVDFTTYKKSPAKSQSLQAPKEMVPTTSPTYTALTKQGYSIIG
SHSGVKICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWITDAPDMIFDGITTAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPH
INELLGIMHSNRISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFW
ERFCACLDILRNRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGT
SAAGSAGLTMENVPFYEEVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRN
DRWATRIDFERFFDLYEGKVEGTRVEDGKVVGWRPEDYVGEETPEWALWGNGGFDPRDAR
VYRKGKGPKVSEGGKATAAALEF
>A0A836HNX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania orientalis|TrEMBL
MIGCALQILVSAGLTFVAFLLFNCLADSAHARGNVAASHTDAAGNTDVFSRQVRAELEQL
GVASAPPAAGSVQSAPPPAEKTPSPAPTAAAAEAVPAAAAAAEILIAYATQSQNSLALAH
KLFSVITAQIHTSPMRTTEAAVCPLVRVMEMREEDSNGSGATDVASGGRLGSKNVCRVDT
LLEENRYALIIFIASTYTDGLAPPRSRVFEAMLRDAFEDHRVPRNALGRKRFAVFGLGDI
AYGEARFNAFAKNLHEWCRGLGAPPFVVPPVYATESKAQSLFRIFSTALLKWVSRATFHS
DGTVTVQKKSEVAVTGSAAAGATGVRSRRPRSVAATATANASMTSAAAGEALGNEGLSCA
CQQSSGQSCRNGAGAGGEENCGCCETEPARNGVAASKSDDDDDDANAENDSMDDVEDLVW
DGTDDADFDINKDPNELPELIYPKLRQSLEKQGYRLVGTHSGVKLCRWTKSMLRGRGGCY
KHTFYNINSSQCMEMTPSLACANKCIFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQ
MIKQMRGVPGVTPERLAAAMQIRHCALSLVGEPIMYPQINRFCALLHQQHISSFMVTNAQ
FPEQLRDLQPVVQLYLSIDAPTPEELKRIDRPLFEDYWDRCLSCVKELAKKRQRTVFRLT
LVNQYNTDNVKAYADLVEMGQPDFIEVKGVTYCGTSPSSTLNMKDNVPRHDQVMGFCKAL
CAELASRHPHYRTPQMDRDEEGGDDVIVIPAEERDRPYHVACEHEHSCCVLIALDKFFFE
GRWHTWIDYERFYDLVESGRTDFTSLDYAAVTPAWATCNSNEKGFDPEQTRVVRKNGRPT
IVTASC
>A0A1L9GXT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeum sp. ARMAN-1|TrEMBL
MPEQLQKRMEKQGYHFVGQHSAVKICEYTANGLRGETLCYKYTFYGIRSWQCIQGTPAIG
CDIGCRFCWRLIPEEEGFKWNELNALSEWDDPEGIVEGMIKEQRRIVSGYKSIADNELKM
RRWNEANEPKHVAISLTGEPTFYPKLAGLLSAFHKKGISTFLVSNGTLPEAIAKLDPLPT
QLYISLQAPDEETYIYVTRPKIKDTWNRFMKSLDMLHTLKTRTVLRMTLIKGLNMKNEEG
YAGLIKRAMPNYVEVKGFSYVGGARNEERGLSLSSMPNHSEIRDFADRLAELTGYKRVSE
HAPSRVVLLARDEESARNRIIDFSKIG
>J1AN89|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofollis liminatans DSM 4140|TrEMBL
MPSAPCEEGRIALRKQGYQFVAPDATAAVKPCMWNKRTLRGGDMCYKHQFYGIESHRCVQ
MTPTLRCNQRCLFCWRSFEHETTDERFCTPEEIADALPALQKKALSGYKVSQYVTSERFA
EALDPNMVAISLSGEPTLYPHLPEYIDLLNERGYTTFLVSNGTMPDMIRRCRPYQTYISV
DAPDRETYLALCNPQEDYWDRIHESLSLLPARRSAVRTTLVKGKNDFDPEGYAAIYEASG
ATFIEVKGYMYLGYSRKRLSRSAMPEHEEVRRFAEAIAGHCSYRITDESPISRVVLMERE
V
>Q3IUQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)|TrEMBL
MPKQVGDPDYHSENHTAAQTCGWTANALRGEGRCYKNHFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELGDVEWDDPEAVADASIELQRKLLSGFGGNDEVPRDVFEEAMEPRHV
AISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLAECDPTQLYVSVDAPDRKTF
GEVVKAVEDDAWDRLIETLDVLAAKDETRTVLRTTLLNGYNMTNPAWYAAMVDRADADFV
ELKAFMHVGNSRDRLDREVMPDHEAVVEFTESIQSFLSEFPVLRDIEASRVALLARDEDT
WVPELKGGSEFWTDGTYAKSD
>A0A814M8Z5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTIDLYIFAASSALTGLVFYYLAGAEWSLWHLFAIPLYTFVFVVFLSLSIIKRFKSLSKP
LQSLTKIIRQEKNGITIVFGSVTGNCRTFAQLTYDKLSKELNYQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDDTPPPSAKWFVNHLQDAATDFRVSKNELEKLTYAIFRCGNS
FYNDNFNTVAKELDRCLSELGAKKLIPTELADENSGKSIYGGREGHYSKWSSQLKSAFQS
PKTDKCDCSNENSIKCCQSLTNNDHPIEKKENDEQLRIESDDDDEDEGCKNGNDDIMDLE
DMGDYMATHSPTKTTKGPPKEMITPVIRKSLEKQCYKLIGTHSGVELCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAMENH
YKIINTFKGVPGVLPNRLAEAMKIRHCALSLVGEPIMYPHINELIDLLHSKQISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKRIDRPLFRDFWERFLDSLRALKDKGQRTVYR
LTLVKDYNTEEIEQYAKLVELGHPDFIEVKGVTYCGDSNASHLTMANVPWHEEVVTFVQF
LCDRLPQYDIACEHEHLNCLLLAHNKVRI
>A0A5B0MTA8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia graminis f. sp. tritici|TrEMBL
MFSLVESITSRFNLTNHTNADRPLNTQVLYSSLSSTTKKLANQLSTSLQSSSQHLHSTLE
SLDHLDLDQLIIQTPVDSTYQLAIFLLPSYNVESPVDSVLAQFRDALFDFRLSKNSLAGL
SFAVIGIGHSDYRDEFCKQAIELDEILEGLGARRLLPLQKIDVAVDPERDLDHYYHSIIQ
KTFHPALKSFSELPTIKSQEIKKYSAENEEEEEEEEEEQDDVDNSDDEFVDYSNSKPLSK
AEKARQKSKRLLNKKINQGEKRTNGTQDIEDLGVGVPQIENLTSNSKDDAENQMIKKDMI
SPMTRKSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLAC
ANKCTFCWRSHTNPVGTSWRWKTDDAEFVVEESLKEHDRLIKQLAGMPGVRPDRFTEART
PRHAALSLVGEPVMFPHIKKYISLLTEKRISTFLVTNAQFPDSLLDLPPVTQLYLSIDAG
TKESLKSIDRPLHRDFWERFLESIDIVRKKKIRTVFRLTLVKGENSDEIKEYAELIRRGQ
PDFIEVKGVTYCGYPGSSNLTIKNSPWHNEVIKFVEDLCEEINDPRYRASSQNGDAQQAP
IAEYGLAAEHAHSCCVLAAHQKYYFDDQWHTWIDYDKFFELVESGQKEFEGLDYCDVTPE
FALFGSPQAGFSPEDQRWFRKKTLAKNSQLEDPLADQTAPSSVGLVVAPGPAQDV
>A0A7K5MH47|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cardinalis cardinalis|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTTRTKRKQSCGSPSSPEG
TSDKLGNGCGPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEIINMEDYD
PEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFL
TRLQALCRGEKKPCRGKCKKGKCKTSGKQSKESSDREHGMSEQDNTEAEELFETSSEEEA
GDTDSVIDVEDLGNVMGHMKKAKVLLLEGVWHGIAVWHSAQFIPAGLGAPWGSEIVPAHG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPHINQLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRIDRPL
FKDFWQRFLDSLKALAEK
>A0A7C4D3E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum pendens|TrEMBL
MESTLSAERYLRAGYRLVGSHSAVAICRWARSAIKGGKLCYKSWYGIKSHRCIQMTPVLN
FCDFACKFCWRMHLPGRFKIPPGWRWDSPAEILDKSIVAQRLLLIGFKGNPAVSSERFLE
AMFPRHLTISLDGEPLLYPKLAELVKEAKSRGLTVFLVTNGSIPVRLRELIRKDAQPTNL
YLSVYGPNREVFEAVADPRIPRAWEMVNESLELLGKFGESRTVVRLTLVRGLNMVEPEGY
AKLISKASPMFVELKGYTWVGESQKRLPITAMPEMRELESFAAKIAEHTGYSVKLTDEKS
RVVLLVRDEEAWEKNLKMVEEWQKLEKERDEKIFEKIVDFTMDDHGYTILRY
>A0A4W6CX41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDPDD
QLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLG
NSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRL
QALAKGEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAALQNVSSEVSELSSSVFLHGTLKE
EGRGDGQMVKLSKLNGVKKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKS
MLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIL
QDAVEKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHI
SSFLVTNAQFPQEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEK
RQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQE
VVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYERFQELVQAHEESG
GQQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A2V1AAK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] duobushaemulonis|TrEMBL
MGTETPLLALCSVLYWLSGGRPTLVAAAWFALFVHKKQKQESPITTPVKSSRIMEVDFTN
AFPETKTEFPKAVPLKKRTRKTRTAKVFKKKETKVSHLTTSSVHLEKCPIYIFYTTLTGS
SLRVAKALHEKVAAIDGVEVPPRLLSLDDDVDDLEEYFLRTPESENPPIYLLVLPSYETD
SPIDYFLEHLTETYQDFRVDKYPLRGLAGFAVLGLGDSESWGGAQFCYQAKSADKWLGKL
GARRLFPVGEVCMKHEGEPKTQDWINGFAELLVDEQPFLYEDDPSAFDSDASGDEAEAEE
EKDVVDVEDMGAIIRASKNKEILEPKQMVAQDSPTYKSLTKQGYTIVGSHSGVKICRWTK
SAMRGRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEK
VLSGALEGHYKKIKQMRGVPGIQIDRFQEAFQVRHCALSLVGEPIFYPHINEFVGMLHEQ
HISSFLVCNAQHPDPLARLAKVTQLYVSIDAPTKTDLKKVDRPLNSDFWERLMSCLDIVR
TIQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGATFCGSSTGNGNPLTMQN
IPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTKFKINDVWHTHIDYKRFF
ELLESGEDFCDLDYICETPAWAVWGAEEGGFNPKDTRYDRKAEKLKKKQARDEAAAKALQ
AKKGESIKAASEFAEHTRELFVS
>A0A4W6CWJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
CYPGESYFMSIWHNRLYLYSAAALVFGSWFAVKMALKKKSFSKDIGPWVYKTMKKNNNCS
DKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDPDDQLADECTS
KSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHF
NTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRLQALAKGEK
KSCSGNCKTGGTCKNKRKDRQVMEEEKAEELIESSSDEDESGLQDEKKSGSVVDMEDLGN
IMNSAKKSKEEGRGDGQMVKLSKLNGVKKIEDEGERREMITPALREALTKQGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKMDPAEKILQDAVEKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINT
FIRLLHSHHISSFLVTNAQFPQEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRF
LDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSL
TMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYERFQ
ELVQAHEESGGQQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A7G9Y6A5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-2c ERB4|TrEMBL
MPVPLPAPTDWDSPVEIKGSIIREHARLISGYGGSETTDMDALREAQKPDQVAISLAGEP
TLYPHLPELIDLFHKDAMTTFVVSNGTQPDMIARIAPTQLYLSLNAPDEDTYLKVCNPCG
NFWEEIRESLRVLGRSKTRTRTAVRITLIKGVNMFDPDGYARLLSMCEPDYIEVKAYMHV
GFSQKRLDRAAMPDHEEVRLFASEIGDVAGYRIADDSKISRVVLLSRDGSVERIQSRR
>A0A4W6CWQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MLNFFLILLLFIIHVSASDSKVPRHEPSPGESYFMSIWHNRLYLYSAAALVFGSWFAVKM
ALKKKSFSKDIGPWVYKTMKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVK
TLGIPAEVTDMKDYDPDDQLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSIQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAALQNVS
SEEELIESSSDEDESGLQDEKKSGSVVDMEDLGNIMNSAKKAMSKEEGRGDGQMVKLSKL
NGVKKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQF
RGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEI
RSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAW
NVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQ
YEIACEHEHSNCLLIAHTKTWDCNGLLCIRAQTIR
>A0A6L2PUQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coptotermes formosanus|TrEMBL
MQVVVNGLFYGNGIMDNRSGQSEPGVGKKKDATCASGLISAGKGPNELPFTVNAVVSKSK
KKVLKNRVASSSSVVSDDKSSSEGSINSSSKLEVYCTGNAKRKVFRSKAGYQSSQTLLLE
SDLTKKNVRNKKCKGQNGCCSKKKGASNTLEGTIETLTVFYGTHTETSKTFSSMLRKDCE
QRGLSVEVFDLADTDPEERLLQETSGSSLCVFILPTYTDGRPPETAAWFCKWLEEASNDF
RVERELLKGMKFAVFGLGNSQYKEHFNEVGKQVDTWLQELHAARFIKLGLGDEDTAASKH
GSIEADFQSWRSQLWLRVDKFKSACQCEGSEQYKVESSCDSSSEGCYSDSDSSGQDSHGT
GVMDLEELGNFSSSLRAAREKKPEENSPREMVTSLLRESLTKQGYRIVGTHSGVKLCRWT
KSMLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDSPEH
ILKEALENHYNMIKQFKGVPGVLPERFAEGMDVKHCALSLVGEPIMYPEISNFVHLLHER
GISTFLVTNAQFPTALRDMSPVTQLYVSVDASTKSSLRKIDRPLFKDFWERFIDSLKALS
EKGQRTVYRLTLVKSWNVDEIADYAKLVGIGKPDFIEVKGVTYCGTSKASNLTMENVPWH
EEVVSFVKQLGNLLPDYEMASEHEHSNCVLLAHKKFKVNGEWWTWIDYDRFHELMKQYYS
TNGAATFTAEDYMCKTPSWAVFGAVQRGFDPVERRWHRKTLQKKDISGC
>A0A813QMP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brachionus calyciflorus|TrEMBL
MDTSEKLLTAASSVGLLMELKSQLRNGSGLKDLKLWPGIKLTFFSSVILCMFVKWLKKRK
ITIPREDLILMENVSSELTDKSQFSIKILYGSVTGKSKYFAEEFSKACASKGLNETSVVN
MKDYDPEDNLFNEIKPNNIVVIFVSTYTDGTPPESAKWFYKFITEMSNDFRYEKGSLKGL
KYSVCGLGNSLYDENFNKIAKDLDKSLNLCQAERVAPLYCCDENTIKSKHSSLEGDYEFW
KNNFFEKLQHLNEVKSSSCCGATETCCKQEKKESVGEEKFEDTTEDEENEDEDDEYLSEV
DDDLNNNEEKVKKSNGVLDLEDLGTVIKKIKTKKPNSEPKEMITPLLRKSLEKQGYKLIG
THSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWKWKMDDPHLIFENALKNQYTMINEFKGVPGVKKEKIEEALNVKHCALSLVGEPIMYPE
INTFIDLLHSKKISSFLVTNAQFPDAIRNLKPVTQLYVSVDAPTKESLKRIDRPLFKDYW
QRYLDSLTALNEKRQRTVYRLTLVKGWNTDDVQQYAKLISLGKPDFIEIKGVTYCGESSA
SSLTMQNVPWYDEILNFVKQIQEELSNEYEITCEHQHSMCLLLAHKKFKINNEWYTFIDY
DKFQELVEEYDKNGTQFTSLDYIAKTPSWALFGSKEAGFDPNEERHMRKKKKDITGC
>A0A843LEV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon|TrEMBL
MPSSPCKALRGQGYQFFSPESSAAVKPCLWCKKALKGGAQCYKHQFYGIESHRCIQMTPT
LRCNHRCLFCWRSFEHEYPGERECTPEEILAGLYDLQKRALSGYKVSPYVTSERFAEALR
PAHIAISLSGEPTLYSHLPELIDLLKAQGFTTFLVSNGTNPDVISQCFPFQTYISLPAPD
QETYLSICRPSADYWERICRSLTLLSTRRSAVRVTLVRGLNDHSPEKYAALFEKSDARYI
EIKGYMYLGYSRKRLNREHMPDHAYIKEFAERIAEYCDYRITNENALSRVILLENRA
>A0A2H9PI17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon CG_4_10_14_0_8_um_filter_37_24|TrEMBL
MDENLKKLLEKQQYRFSGNHSVVKICRWTKKSLVEGKVCYKEKWYPPVKSHRCMQMSPSL
VCNHRCLFCWRLHSGDRGFSWKESFEGLVLDEPKDILEKCIEQRKSLLTGFKGFERVDKR
KWEEALKPNMMAISLTGEPTMYPKLDELIQEAKRMNIISFLVTNGTLPDRLQSLNTKPFQ
LYVTLPAPNKETYKKLCQPSTPKLWDKIMETLELIDSFDCRKVIRLTLVKGLNMVEPEEY
AKLIEKANPDFVEAKGYVHVGESQKRLPMDAMPYHEDIIEFSKEIEKHSSFRIKDVFKPS
RVVLLKK
>A0A803WGQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ficedula albicollis|TrEMBL
MDTWSFFHTCLVSIWLHRFYIYSAIAFGISLWIVIQFTTTRTKRKGEKSHGNPSSPEGTA
DKLGNGSAPPQAQEVHVAGVKIFYGSQTGTAKRFAQALAEAVTSLNLPVEVINMGDYDPE
DGLSEETSSRNICVFLVATYTDGQPPESAAWFCQWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLSR
LQALCRGEKKPCSGKCKKGKCKSSGKQSKESSDNEHRTSEHENTEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKREQELQEGAAGAGSKEEAERREMITPALREALTKQGYKL
IGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWRTDPPEVILQEAMEKHQSMIRQLKGVAGVKAARLEEALAVKHCALSLVGEPIMY
PHINSLVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKD
FWQRFLDSLKALAEKGVTYCGESSASSLTLANVPWHGEVLSFAQELARLLPEYGVACEHQ
HSNCLLLAHSKFQVDGQWRTWIDYGRFQELVREREQSGGSRSFSAAEYTARTPAWALFGA
RERGFDPLHVRVPRRSKARLASGC
>E9B8G5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania donovani (strain BPK282A1)|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTAPPAAAEDVICPLVRVMEMREEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGVA
PPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGLG
APPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAASA
TEARSCKGGSATLATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCAC
RKADTIADGVAVSKSDDDDDDSNAENDGMDDVEDLVWDGTDDVDFDLSKDPSELPELLYP
KLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACAN
KCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLAMAMQIR
HCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRNLKPVVQLYLSIDAPTP
EELKRIDRPLFEDYWDRCLSCVKELARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQPD
FIEVKGVTYCGTSSNSTLNMKDNVPRHDEVVGFCKALCAEMASRHPHYRTPQMDKEEEGG
GDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRTDF
TSLDYAAVTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTASC
>A0A337RWD0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Felis catus|TrEMBL
MTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQEYDPDDH
LVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVFGLGN
SAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTKFISRLQ
ALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGKIMNCV
KKEKREKELQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEM
ILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFLKLLHEC
KISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNSLKALA
AKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWH
EEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQELVQEYED
SGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A094G629|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4517|TrEMBL
MANNDLIGADIASDAMGNYLMVLWHTYRIPLILTVLALLLLTRTVLHLKVGRGKIIYTPP
ATPTEKTPLAANLKREELTEKAPISAEVKKAGPKRVVGKVTRKKSPLRDQPASKDVKFQV
LVFYSTLAGSTERTAQALTTKLADTLKANAGSGQYEFLSPIAHDLAELEDYDEYFLGLPK
PEDDGLDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWLAKLTARKRAFPLGMGDTKVDAQDRLDEWRQGIEDVLQNL
GQTGNLGEGVVGSGDADESDGIEDVLQNVGQTGNLGEGVVGSGDADESDVEDADEDDVEV
QSDGAVKLKRKSKKKVTSSMDDVEDIGRILQKGQAESEDQDQDEDEGAIDFTTYGKKTPA
PVAAPKEMVPKGSPTYNALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASH
QCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDQPEDIFNGVKAGHYQKIKMMRGVPG
VRAERFAEAMRIRHCALSLVGEPISYPYLNEFTAMLHKERISSFLVCNAQHPDQLATLKP
VTQLYVSIDATNRESLRKIDRPLHRDFWERFQRCLEILREKRFEQRTVFRLTLVKGFNIE
DEAEGYADLVEKGLPCFVEVKGVTYCGTSTSGAAGLTMQNVPFYEEVCAFVLALTAALEK
RGLKYGIAAEHAHSCCILIASDRFKKEGKWHTRIDYAKFFEHLESGKPFTPEDYMGPETP
EWATWGNGGFDPRDERVYRKGKNKVPLRVEGEEAEPKEVETKEVLCALSILGIGGEKIGG
DKAAHGIQVSPRRPGGFQNQPTISRLQAPTSSQSADGRPMGLLVAVRQRVAMLSGDAKAT
LVAGNGFGEARSAYTHLRLELMSEPIAIDGIEACLSQYGYSRETTYRDLSMISGAHLSSI
YHRIHGRPSKREAAYNRQYLTYEEEEVIATCLLSMAQSGYCLPRQFIRKIAHHVKRQRNS
IEPVHQYQSGGDGALRPGKNWSTTFWKRHPTLKIALEIPKKNTKKSDQHIFDHIDAWINI
IAPKLDTLKALNKNTYHVIATGGILKFPAIIPEIVSEDTIHAYLNANDKGKVLTAIECSS
MDGQFINPLIISPTVAERNQTLDHVFNCHFDQSSNGYLDSEVAIKWVTNIFEPHTRAVAN
GRPRFLISDALTYYNTRELRVFCKKNRIHLCGLHSMVVQRLQFHTASSFEQLQISLREEY
SRAYSYSRDCEKLQFSLLYDRARQRAIDVHTTQAQFQDEDSSEASIDSSASSFEDSPQTI
EDTAQTTKDTPKTVEGLVSLCQNIENDLKCEALSEAVKGRIQHLLDIAMIGATI
>A0A2V2N6I3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum stamsii|TrEMBL
MPSEPCEPPEKVLRKMGYQFFHPDSSAALKPCLWCKRSLTGGDQCYKNQFYGITSHRCVQ
MTPTLRCNHKCLFCWRSFEHEYIGEKELSPADIVSKIPFLQKKALGGYKVSYRVTKEKWE
EALRPDQYAISLSGEPTLYTHLPELIDLLNQTEGTTFLVSNGTMPGVLRNCHPYQKYISL
TGPDRETYLKIARPDEDYWDRILESISDLGHETDAGNRTAIRVTLVKGINDQDPAGYARI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHEEIEQFTKQMLPHLSYKVRGENTLSRVI
CLERDS
>A0A0V1CPK8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella britovi|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNVRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENEN
SSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKI
CRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTD
PAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISK
MHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSI
DILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSKDSKITMAN
VPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAE
RFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A2B7Z9Y4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emmonsia crescens|TrEMBL
MAGDALGIAAQGLFSLWHRYRVPILFLAPVVFAVVQLFPRNPKPDTPSPASLSPSQKNKQ
TRDAKSDEREVESLSRNDSLAAAQPKGDSSRSSSADSSNKRAKQPSNGPKRVHGTKPAKN
GAKNRTNPEGLAQDIAIQPLVFYASLTASTETYAKSFCDRLQQTALPLPENSKGTILTPE
LHDLSYIELDDYFITAPKPPDSAPNTRFFYCILIPTYNIDTMINTFLGHLDETHNDFRID
TSALSELAGYSVFGFGDREGWPTEEEGFCSQAKEVDRWMAKLTGKKRAYPLGMVDVKGGN
IQKVLSEWCDGLRDVMFDLMASGGLGEGVPGSGDPVESDEEEIDDDDEENDENSENSRKK
GRKEQIVDLEDIKFGVSNDKKTSTDPQLLPIDFTTQSRAQPAKPAPQLEMVPTSSPTYAA
LTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFC
WRHGTNPVGTTWRWKVDPPDLIFDGVKTGHYKKIKMLRGVPGVRAERFAEAMRIRHCALS
LVGEPIFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRESLRK
IDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCFV
EVKGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELVRRGLGYGIAAEHKHSCCVL
LASNRFYVNDRWHTRIDYDKFFTLLEKEKSDGIPFRPEDYMRETEEWALWGNGGFDPKDT
RVYTRGRNKAKLNAALKESQANTASVEG
>A0A3Q2U6Y1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gallus gallus|TrEMBL
MAGGLDVSMDTWNFVYACLVSLWLHRIYIYSVTAFGISLWIAVQFFTTKAKRKDEHSNGN
LVSSEVVEDKLVNGYATLQPKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVTCFNLPVEVI
SMGDYDPDDCLAEETTSKNICVFLVATYTDGKPTESAAWFCKWLEETSNDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFEA
WKSKFLNCLQALCRGEKKPCSGKCKKGKCKSQGKPSKESSNPERGAPEFENTETEELFET
TSEEEADAEEAGGTDSVVDVEDLGKIMSHMKKAKRERELEDGDAGMSLLGETSGRKEAGE
RREMITAALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREALENHRNMIKEFKGVTGVRAERL
EEAMTTKHCALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLYV
SVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADL
VSLGKPDFIEVKFKINGHWCTWIDYERFQELVRAHVDSGGTQTFTATDYTARTPHWALFG
SNQLGFDPLDVRYQRRGKVRDISGC
>F9XK00|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zymoseptoria tritici (strain CBS 115943 / IPO323)|TrEMBL
LLLLWHAHRTEILISAGFLVAIVRLTLHWRSTKTKAILTPPLGSPVTEKPIRFPEVVQEK
TVPTAQPVKTNGPRRVKGVKKVKKQEQAKDERPPIDKIQPYIFYFTLGGSTKAYAEKLAE
SFILPDAKDRVLPPQVHDLTDIDYDDFFISPPKYDSPGTAAFYTILIPSYNIDTELHNFL
SHLQETHHDFRIDTAPLQTLAGYSVFGFGDMQEWPTEQEGYCVQAIEVDKWMAKLTGKKR
AYPLGMGDVKDDVELRLEEWRRGVQTIVDDLSQGKGLGEGVPGSGDPIESEDEADEDYDD
GETLITITADLEDIRAPIPVDFTTSKKSTSTTTGPPKEMVPVNSPTFNSLTKQGYSIIGT
HSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCVFCWRHGSNPVGTT
WRWQVDPPEQIFEGILAAHYKKIKSLRGVPGVRSERFAEAMRVRHCALSLVGEPIFYPHI
NQLLAMLHAQHISSFLVCNAQHPAHLAALGPVTQLYVSIDASNRDSLRKIDRPLHRDFWE
RFCDCMDILRQKRYSHRTVFRLTLVKGFNIADEVAGYADLVQRARPGFIEVKGVTYCGTS
TSAGAGLSMANVPFWEEVQEFVLALAAELKTRGVQNDGMEYGLAAEHQHSCCVLLADKER
FYRENAAGEGKWHTLIDYEKFFKLVEMGGEFKAEDYVSAEPTADWAGWGRGGFDPRDVRV
DRKGR
>A0A8C4LLV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Equus asinus asinus|TrEMBL
MDPSLDTWDFSPLISLWIHRFYIYWGFAFGISLWICFQIVIRKQDKTSQEKSLSKATRDL
VTNGYISLQEKEVFVSGVKIFYGSQTGTAKGFATILAEAVTCLGLPVAIINLKEYDPDDH
LVEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEASIDFRFGQTYLKGMRYTVFGLGN
SAYASHFNKIGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGSIEGDFRAWKTKFISRLR
ALSKGEKKSCGGNCKKGRCKSSQHGSEEMEPGSPAQDGLHQRDTEEEEPFASTSEEESST
EDHQSLSSVVDVEDLGKIMNHVKKEKREKEQQEEKTSLFRNTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIKNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVHELVDLIPNYEIACEHEHSNCLLIAHKKFKI
DREWWTWINYNRFQELIQEYEDSGGSKTFSAEDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A096NYS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Papio anubis|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKMQDRSLQEKYVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASIDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKVDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASNLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A1Y1JI54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium gonderi|TrEMBL
MGKEDEIVNRKNMFKRIFEQHIVRSKKRAKINLRIVYGSEGFTTYRKAKEFLNELIHFFK
DIENICNEINGIITKEGGDHYTANGKVNEVDHDDNADSDHNAVSDHNADSDDGGLMDYFK
EYSKLLEKKKSGGEREQINSLHADDEKEQNGGIKEFEKRRNKCSNNFVNYADICINTNIC
TVNFDFLNGNEFNDYNFLENTNEYDLNVLLLFVSTSSYGSFPSNCYKFEQLLEDLHNDFR
IEKNFLKNIFYSCIGFGNKQYGNNYFCAPAKKCDKYLSNLGAQRLFKTLKFCDEENNEDL
FHIWKCSIFKTISLGILFYCFNYTQLFTFMSYADRKIYSSLHHYCFFFSAKANSKWIKGK
DSKIKRKTEIIPIRLTQAGKNPLEIEYSHEPSEKNNLQMLNQSKLDHALRNGGSNNATLN
ECEKYITDVRKPPNINECEDEATNNTIPNGRRERENNDNHSSSISVCSSGDELEDLITDK
PKDMLSSKQRNKLVKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMEAT
PSLACANKCVFCWRHHKNPVGTGWKWNKDAAEMIVAEGIEKHKGMIKELKGAHGVIKERF
DNAMNVRHCALSLVGEPIMYPDINKLIDELHSKNISTFLVTNAQFPNELQKLHKVTQLYL
SIDASNEEALKNIDRPLFKDFWDRYIKCIKLLRKRKERTVFRFTLVKEYNMMNDEILSYS
KLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAYNLIHANSYLLDTYEIAC
EHRHSCSILIAKKIFKINNKWHTWINYETFQFLVKHNKDFTATDYCAETPSWAIVGAEER
GFNPCDERVYTKGKKKNKAPHTEDNNVQ
>N1NWM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain CEN.PK113-7D)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGG
>A0A3B3V4A3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia latipinna|TrEMBL
MLALFTVISFLTGSLPASDTKVPPDVHSPTENYLLWMWNNRLYVYSAAALLLGFCFLLQV
TRRKINHTKDSGSKDSGLKVQKAAKNEVSSDEDADVHVSGVKIFYGSQTGTAKGFASELS
QEVQALGIPAEVMDMKDFDPDDRLADECVSKSVCVFLVATYTDGRPTQNAEWFCKWLEEA
STDFRYGNSFLKGLRYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSARRVLSRGEGDGNVV
KSRHGSVQADFRAWKVRFLSRLRALARGEKKSCSGNCKSGASCKNRKKHGAPEEEEHGSE
VELIESSSEEEESGWPDEKTSRSVVDVEDLGNIMSSVKKAKGVKGEQGGQMVKLSKHNGV
MKTEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGV
PGVKPERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPEEIRNL
VPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVE
ELQAYAELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPHYQI
ACEHEHSNCLLIAHSKFKVNGEWWTWIDYDRFQDLVQAHEDSGGQQTFSALDYTAKTPSW
ALFGSNEQGFDPADTRFQRRNKTKDISGC
>A0A7J0GHN9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Actinidia rufa|TrEMBL
MPPASAARLTVIAVLSAATVYCFYKSRRLRLLKKLSSPNPNPNPTLSPSKGKLFFVSQTG
TSKTLARRLFDLLTSHGLAFDLVDPKDYEPEDLHKENLVLIVASTWDDGKPPPNDGFFAD
WLAESSDDFRVGSMLLSKCSFAVFGVGSRAYGDTFNAVAKEFSKRMRSLGATEVLPMSEG
DVDGGDLDVVFDGWSEKLIGVLKDGALENGNKSEFGGDENHESDFEVISSSDEEDKDENG
ADSGIVDVEDIAGKAPSRKSMALGRPNGKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKM
DDPLEIVNSAIDLHTKMIRQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEINSLVD
ELHRRRISTFLVTNAQFPEKIKLLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFVDS
LKALKEKQQRTVYRLTLVKGWNTEDIDAYSSLFSVGNPDFIEIKGVTYCGSSATSKLTME
NVPWHSDVKAFSEALAQKSEGQYEVACEHVHSCCVLLAKVDKFKVNGLWFTWIDYEKFHD
LVATGRTFDSKDYMAATPSWAVYGAEEGGFDPEQSRYRKERHHKSSH
>A0A3M6YT25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MPRRMSGSARMGEACSLGIPSFVCLMVGFSKVPLKVNIKRTEMPIAPGECTAAHVATNIH
PPPMMDMEKILQLPEELLFLWHAHRAEVLLSAGLLFALLRLAVHWRTRKSKEVLTPPVLT
PVDEKPLAVPSAKETLADADHYEAPTPKPAVQRPKPGPKRVTGTKKSKSAASQEAQVIEK
IQPIIFYYTLGGSTKVYAESVAQDLTTSSPSPILEPQLHDLADTEYDDFFLSIPKAEKTA
HFYLLLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSKLAGYSVFGLGDKHEWPSEAEG
FCTQAVDADKWMARLTGRKRGFPLGFGDVSKKDEADVMLKEWTEGVSSIMKDLAEGKGLG
EGVPGSGEPIESADEASEDEDETPAPRKSKRKPAKRSKTDDLEDLKAPIPVDFTTSKPTS
TTQPPPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQ
SHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGV
PGVRAERFQEAMRIRH
>A0A5N6RPM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Carpinus fangiana|TrEMBL
MAIARLGRQAKRPCGFCIKMTAVVILGLCFIFVWSMFSSSSSSVVTQRESFDDIAEPVST
NARTSSSGSQSNKKGVQKHGLNNEDKKEKVESDLGRKDEKKVNGSAALVVKEHKPAKTGG
KEVAKEKKGKHIKEVAEENDGSKDSEGPLFDPKSHYTWKLCSTRSKHNYIPCIDIESGTG
KLQSYRHTERSCPRTPLMCLVPLIHGGYALPVRWPESKLKILYKNVAHPKLAAFVKKHSW
MVESGEYLTFPEDQSEFKGGVVHYLESIEEMVPDIEWGKNIRVVLEIGCTDSSFSASLLD
KEVLTLSLGLKDDLVDLAQVALERGFPAVVSPLLTRRLPFPSDVFDAIHCGGCGLSWHSN
GGKLLLEMNRILRPGGYFILSTKHENIEEEEAMSRLTASICWNILAHKTDEVSDVGVKIY
QKPESNDIYELRRKKNPPLCKENENPDAAWYIHIRTCLHSIPSAIEQHGTEWPEEWPKRL
ETYPEWMNDKEKLIADTNHWKAIVDKSYLTGIGIDWSNIRNVMDMKAIYGGFAAALSQQK
VWVMSVVPVHAPDTLPFIYERGLVGIYHDWCESFGTYPRSYDLLHADHLFSRLKNRCKRP
VSIVVEMDRILRPGGWAIIRDKVEILDPLEGILRSLHWEIRMTYAQNKEGDLAIFPRRTR
PEKEIFTMSFSSVPARLTLLALLSASTFYCFYKSRRLRRLKLSLNPNPNPSISKPKLFFV
SQTGTSRALADRLFDLLASNDLPFDLVDLKDYEPEDLPKETLVLIVASTWEDGKPPQNAK
FFSNWLSESAEDFRVGSLLLSRCKFAVFGVGSQAYGAAFNAVARDFSRRLKALGAKEILP
VWEGDVDSGDIDEVFGAWSAKVVGVLKGGVVENGGVLCSEVGDDSDAVSVGVSDEDEGSE
DGGTGSEIVDVEDIAGKGPSRKTATVAETNGRLNGKKEMVTPVIRASLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQ
WKMDDPLQIVNSAIDLHTNMIKQMKGVPGVTLERLMEGLSPKHCALSLVGEPIMYPEINT
LVDELHCRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFADFWERF
IDSLKALREKQQRTVYRLTLVKGWNTEEIDAYSNLFSLGKPDFVEIKGVTYCGSSATSKL
TMENVPWHADVKAFSEALALRSQGEYEVACEHVHSCCVLLANTEKFKVNGKWFTWIDYEK
FHDLVASEKPFNSMDYMAASPSWAVYGAEEGGFDPGQSRYRKERHHKSSR
>A0A1B8DP19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. 23342-1-I1|TrEMBL
MANNDLFGADIASDAMENYLISLWHTYRIPFILTALALLLITRTVLHLKVGREKIIYTPP
ATPTEKAPLAANLRREKLTEKAPISADVKKAGPKRVVGKVTRKKSPLRDQPANKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKAGAESSQYEFLSPVAHDLAELEDYDEYFLGLPK
PEEGGPDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLDEWRQGVEDVLRNL
GQTGNLGEGVVGSGDADESDVEDADEDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQAESEDQDQDEGAIDFTTYGKKAPKPVAAPKEMVPKGSPTYNALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
GAAGLTMQNVPFYEEVCAFVLALTAALEKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEG
EEAEPKEVEAEEAEPKEVLVEI
>A0A0V0US75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella sp. T9|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVLDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENEN
SSDAEDAENSANNVGDIEDICERCVVMIHFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLV
GTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVG
TEWKWKTDPAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYP
HINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDF
WQRLMNSIDILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSK
DSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDY
EKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A1U8C9N5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mesocricetus auratus|TrEMBL
MGPPLDVWDFSSPLLLLWMNRFYIYLGCALGITLWICVQVVIKKQVIRSQEKSVPGAPDS
SLPLQKKQTHVSGVKIFYGSQTGTAKGFAVTLAKAVTSLDLPVAIINLKEYDPDDNLIGE
ITSKNVCAFLVATYTDGRPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQ
SHFNKVSTNVDKWLWMLGAQRVLTRGEGDRNAVQSKHGSIEADFTAWKTKFISRLQALQS
GEKKACSGDCKKGKCETTQPGAGEVRPHLQGGLRPGGAEEEEPCESSSEEESGAQGYQSL
NSLVDVEDLGNIMNPMQKEKRERAQQEEKAGVKRNPETSVDSEGRAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIDSHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEP
IMYPEINRLLKLLHQHGISSFLVTNAQFPEEIRNLTPVTQLYVSVDASTKDSLKKIDRPL
FKDFWQRFLDSLKALAAKQQRTVYRLTLVKCWNVEELQAYAELVSLGNPDFIEVKGVTYC
GESAASNLTMANVPWHEEVVRFVQELVDLLPDYEIACEHEHSNCLLIGHKKFKISGEWWT
WIDYSRFQELVLQYEESGGSKTFSASDYMARTPQWALFGARERGFDPKDTRYQRKNKAKD
VSGC
>A0A1F6Z3B2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon RBG_19FT_COMBO_34_9|TrEMBL
MIPENVKEILKKQHYAIVGKHSAVQVCRWTKKSLRDEGVCYKEKFYGIKSHLCCQMSPAV
MWCPNRCLHCWRAVEMTIDNELNGKIDSPKEIIDGCIEAQRRLLQGFNIDKNSKKKQLSR
ANQEKFSEAQEPMQFAISLSGEPTVYEKIGELIEELRKRGKTSFLVTNGLYPEKLEELEK
KKQLPTQLYISVNTSNEELYKKFHRSSKKDAWERLNKSLEIMTRLRNKTRTIFRMNLILD
MNMLPEHAEEYAELIKKTNPMFVEIKGVMSVGFARQRIPYNKMPYHKDIIEFSKKMLNFL
PEYKILDEKKESRVVLLGKDKADMKIKKGEI
>A0A5D5AJQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba swarupiae|TrEMBL
MSDSADTGDSPTGAGTDADGGDDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYK
NIYYGIESHRCIQMTPVVRCNERCVFCWRDHNGHAYEMDDVEWDDPEAVVDASISLQKKL
LSGFGGNEEVPREVFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRGITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVKAMEDDAWDRLLETMDVLAEKDETRTVLRTTL
VKGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSSMPDHDEVVEFAESIQEY
MPEFTECKEVPASRVALLSKTADTWVPKLKKDSEFWEREAVTGD
>T2GI01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp. CaT2|TrEMBL
MYLEESQRRMERMGYRFVGEHRHSAVKTCLWTKKSIVNEGVCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTGTAWEGPHDEPADIIDGAIEAQRKLLCGYLGNERADKIKVM
ESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLSEEPTQLYI
SLDAPDRDTYKELCRPQIPGAWDLLNSSLELMPSFSCRKVLRITAVRHINMKDPVGFARM
IERARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDESRESRVV
LLA
>A0A2G9GEN7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Handroanthus impetiginosus|TrEMBL
MSPSLPPSRLTILTLLSATATFYFFYKARHRRRYLVTRLRQALTTLDSQSLNLASSKRGK
LFFLSETNTSKTLAQRLHALLTLNDIPFDLVDPKAYEPEDLCKETLVLIVASTWENGGPP
QNGAFLVNWLADSADDFRVGALALKECKYAVFGVGSRSYGETYNAVARSVSLKLRKLGAG
ELVDLGEGDVDEGNLDEVFDRWSTKIVGVLKGNLGENGWHSKNYGVVSESEGDGEFSEED
DAEAGDGNESGIVDLEDIAGKAPSRRSAVAAKANGKVNGQVLNGEKEMVTPVIRANLEKQ
GYKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWQWKMDDPLVIVDTAIDLHTKMIRQMKGVPGVKAERLSEGLSPKHCALSLVGE
PIMYPEINSLIAELHRRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRP
LFGDFWERFVDSLKALNKKQQRTVYRLTLVKGWNAEDVDAYSSLFDVGNPDFIEIKGVTY
CGTSATSKITMENVPWHSDVKEFSEALARKSKGAYEVACEHAHSCCVLLAKVEKFKVNGQ
WHTWIDYDKFHDLVASGEPFSSKDYTLPTPSWAVYGAEEGGFDPQQSRFRKERHHKSARP
AGVI
>A0A7K9LHW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhabdornis inornatus|TrEMBL
DVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTKTKRKVTEPVSTSDKLG
NGCAPSQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPEDGLV
EETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAAIDFRVGKNFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDKWLWMLSASRVMTRAEGDCSVAQSKHGSIEADFEAWKGKFLTRLQAL
CKGEKKPCSGKCKKGKCRSSGKQSKESSDHEHRTSEHENTEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGHMKKAKREQELQEGAAGAGRKEEAERREMITPALREALTKQGYKLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEW
RWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHIN
RFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQR
FLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISIGKPDFIEVKGVTYCGESSASS
LTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWIDYGRF
QELVREHEQSGGSRTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKARDISGC
>A0A6J5W773|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus armeniaca|TrEMBL
MSLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSSSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNGLGFDLVDPNHYEPEDLPKETLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGAAEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNGVVAECEAESFDGSDEDDEEEDDLESEV
VDLEDIAGKGPSRRRTVTVTKTNGTVNGQKEMVTPVIRASLVKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPL
EIVNSAIDLHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHR
RRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSL
KEKQQRTVYRLTLVKGWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPW
HADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSS
GRPFDSKDYMAATPSWAVYGAEEGGFDPYQSRYKKERHHRSNQ
>A0A7S3PJD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aplanochytrium stocchinoi|TrEMBL
NLEQEDCIFFVVSSWTGGTPPENCIGFFQWLEDMTLDFRVDKSKFLKNVTFAVFGLGNSE
YNSKDFCGAAKKLHNMLTSLGAKQLLPVCLGDASVEMDDQFAEWMKNVKHRVATANVDPE
IVSNQLNVITNNDKEEESDLEVEPEDLINDRYLELEAEEEENETQLIDLEDIVTSPGKGP
QDMVTKAQRKSLTKEGYKIIGSHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMEATP
SLACANKCVFCWRHHKNPVGKEWRWKMDPPDMIVSEAINLHRKMIKTMKGVPGVQPNRLE
EAYTVKHCALSLVGEPIMYPRINEMVGELHQRDISTFLVTNAQFPKAIIDLDPVTQLYVS
IDASNKDALKAIDRPLFGDFWERFTGSLKALREKGQRTVYRLTLVKQWNMEDENDEEELC
QYVKLLELGQPDLIEIKAVTYCGKSDASNLTMKNVPWHSEVRKFADTLCERTNGEYGTAA
EHVHSCCTLLARKKVFFKDGEWHTWINYPKFHQLMKEYYASNGEKTFSTVDYLEKTPSWA
LWGAQEEGFDPKETRHYRKKKTKTLVGEKSMSP
>A0A8B9QMM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apteryx owenii|TrEMBL
MDPWNFFYTCLTSLWLHRFYIYSSVALGISIWICIQFFTSKTIKKDEKFNGNPASAEVAE
DKLVNGYATMKAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVTSLNLSAEVINMGDYDPD
DSLTEETTSRNICVFLVATYTDGQPTENAAWFCKWLEETANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLGR
LQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDHEHGASEYENAEAEEFFETTSEEESNA
EEAGDTNSVIDVEDLGKIMSHMKKAKKERELEEGGGRTSLSQESAGRKEEGERREMITAA
LREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKH
CALSLVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKD
SLKKIDRPLFKDFWQRFLDSLKALSEKGVTYCGESSASNLTMANVPWHEEVVHFVQELAD
LIPDYEIACEHEHSNCLLIAHKKFKINGEWCTWINYDRFQELVRDYERSRGSKTFTAADY
MAKTPHWALFGSRERGFDPLDIRYQRKNKTKDISGC
>A0A8J8JQ43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronococcus sp. JC468|TrEMBL
MSDSADPGSSADGDDAPAQVSSPDYHSENHTAAQTCGWTANALRGEGCCYKKVYYGIESH
RCIQMTPVVKCNERCVFCWRDHRGHAYELGDVEWDDPEAVVDASIRLQKKLLSGFGGNDE
VPREVFEEAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLRDCDP
TQLYVSVDAPERHTFDRVVKAVEDDAWDRLLETMHVLSEKEETRTVLRTTLVDGENMHHP
DWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSSMPDHEEVVAFAERVGEYMPEFTEVKG
VPSSRVALLSKTTDTWVPKLEKDSEFWERDPMTGD
>A0A6P3QI39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pteropus vampyrus|TrEMBL
MDPPLDTWDFSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQSFIFKDKNSQEKSVPK
TTQDLMTNGYISLQKKEVFVSGIKIFYGSQTGTAKGFAADLAEAITSLDLPVAVIDLKEY
DPDDHLVEEVTSKSICVFLVATYTDGRPTESAEWFCQWLKEASTDFRFGKTYLKGMRYAV
FGLGNSAYVRHFNKVGKNVDKWLWMLGAHRIMTRGEGDCDVVKSKQGSIEADFRAWKTKF
ISQLQILLKGEKKPCDGNCKKGKCKSNEHIAEEIEPGSHAQDGLHQRDTEEEEPFESTSE
EEPDTEDHQSLSSVVDVEDLGKIMNRVKKEKREREHKEEKTGLFRNTVKNEASERRAMIT
PALREALTKQGYQLIGSHSGVKLCRWTKLMLCGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTV
KHCALSLVGEPIMYPDINRFLKLLHENKISSFLVTNAQFPMEIRNLKPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSP
DFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAH
KKFKIDKEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMAKTPHWALFGASERGFDPKD
IRYQRKNKSKDISGC
>A0A814GSR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Didymodactylos carnosus|TrEMBL
MIDLYVLAAGSALTGILFNCVIVLTIFKRFFSTGKKIVEKASTENKTENDTISVVYGTVK
GASKKFAELTYEQLIQNGLSANIYDMKDISDPEDFLNTQAKHSKTMVIFISTYEDVTPPL
SAKWFYSYVKEAAYDFRVSKDQLNKLKYSIFGCGNSLYDTNFNKIAINLDEYLHELGSTK
ILSTELADENTIQSPYGGLEGHYSKWINALMTTLQNKCDSPATLIGTKDVHCKNPESCDC
KTNEENAECNNDKEDADGSAEQQYESDDEGAGGCKDSSADIMDLEDMGHYVSTAPLKNTV
SESNGTKEMITPLIRQSLEKQGYKLIGSHSGVKICRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAETLYNGATQNHYKMIKEFRGVPGV
LPERYAEAMKIRHCALSLVGEPIMYPHINELISKLHKNQISTFLVTNAQFPKEIETLEPV
TQLYVSVDASTKETLKKIDRPLFKDFWERYLASLKALKSKGQRTVYRLTLVKGYNTEQIE
QYANLVELGDPDFIEVKGVTYCGESNASTLTLANVPWHDEVIEFVKLLCERLPQYDIACE
HEHSNCLLLAHKKFQINGIWHTWINYEKFHELIQRYLDSNKTELFTSLDYVSETPKWAVI
GSESRGFDPNDTRKHCPTMSHQPSMEPRARIEKMSAEVVDSNPYSRLMALQRMGIRIREY
SVLIVGVGGVGSVAAEMLTRCGCGKLLLFDYDKVELANMNRLFYQPHQAGLSKVEAAADT
LR
>A0A8B9TLP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anas platyrhynchos|TrEMBL
MFFFVFSQGEKSNGNLSSEVVEEKQANGYAALQAKEVYVAGVKIFYGSQTGTARRFAKGL
AEAVISLNLPVEVISMGDYDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEE
TANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNV
AQSKHGSIEADFEAWKTKFLSCLQALCRGERKPCSGKCKKGKCKSQGKQSKESSDHEHGA
SEYENAELVETTSEEEADAEEVGGTNSVIDVEDLGNVMSHMKKRERELEEGHVGTSLSGE
TAGRKEAGEKREMITCSSERRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
MEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVAGVK
ADRFEEAMTAKHCALSLVGEPIMYPEINRFLKLLHQFPDEIRNLEPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELRAYADLVSLGKPDF
IEVKVSCTSASSLTMANVPWHEEVVRFVQELVELIPDYEIACEHEHSNCLLIAHKKFKVD
GEWCTWINYERFQELVREHERSGGSKTFTAADYTARTPHWALFGSSQRGFDPLDVRYQRK
SKAKDISGC
>A0A094AI78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-3775|TrEMBL
MANNDYFGADIASNATGNYLVALWYIYRIPLILTALALLLITRTVLHLRVGREKIIYTPP
PTPSEKAPLAANPQREQLAEKTPISSEVKKAGPKRVIGKVTRKKSPVRDQPADKDVKFQV
LIFYSTVAGSTERTAKTLTTKLADTLKAGAESSQYEFLSPIAHDLAELEDYDEYFLNLPK
SEDGGQDVKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDAKVDAQERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEDADEDETEVLPDGAVKLKRKSKKKATSSMDDVEDIGRI
LQKGQAESEDQDEGAIDFTTYGKKNAKPVAAPKEMVPKGSPTYNALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWV
VDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNEFT
AMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAG
AGLTMQNVPFYEEVCAFVLALTAALEKRGLKYGIAAEHAHSCCILIASDRFKKEGKWHTR
IDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEGEE
GEKEVEKQDTPVLVEI
>A0A7C1I7A7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp|TrEMBL
MHSEACKALKKQGYQFFNDRSSAALKPCMWNKRTLRGGEMCYKHTFYGIESHRCVQMTPI
LRCNQRCLFCWRSMEHEVVEEEEIDPAEIVERVPALQKKALSGFKVSQYVTPERFSEALD
PTMVAISLSGEPTCYSRLPELIDLFNGEGYTTFLVSNGTRPWVLERCRPYQLYVSLDAPD
RETYLRICRPKGDYWEFLQESLTSLASRRSVIRVTVVQGLNDFGAEGYARMIQDSGADFV
EVKGYMYLGYSRKRLSRENMPEHEHVREFAEAIAEHCDYRLLDQRPISRVVCLERGP
>A0A0D2IMV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cladophialophora bantiana CBS 173.52|TrEMBL
MDLGDAGAAPVILADWLGRLLTSWHENRVVLSTVLGLCVLAVIVLRRHAYKITQRGSPTL
EKAEWLSQNDDARLQIAKDRRIETPPRNTSSLTSGQARKPLTTVAAPRVVTGRKPPSSRG
GQLALQRRREPSRIQPLIFFSSLTGTTERLSKNVAADLEEVSIAQPALLRPQIHDISYID
LDDYFISGPKTPAPDTGVLYFYLLLIPSYNIDTILNTFLSHLDETHNDFRIDTAPLSMLA
GYTVFGIGDKEGWPTEEKGFCSQAVEVDKWMAKLTDRKRAYPVGLGDVKSNLDRSLKDWI
GGVSSILKEVSKTGALGEGVPGSGEPLESGDEDEPEEVDEDIEFPDSGRNKRRKLANTPD
LEDVGGKANSYAAPMAIDFTTYPSPPSAPTSLKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPKLIFEGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHSEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWDRFNS
CLDLLREKRFEQRTVFRLTLVKGFNIEDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVEFVEALEKALAKRGLEYGIAAEHEHSCCVLIASKRFFINAKWHTL
IDYDKFFNLLESARDFTPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEKKTTSDDSG
ENQNGMRVGDEKVMP
>A0A507ERS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chytriomyces confervae|TrEMBL
MKVTVLFSTQEGTTETIAEKAAADIAKRLNGTDAAVEVVHIKEFNIDSLPKRSPNDPVLF
VLTTYIDGGPADDAAWFGSWLEDARFDFRVSKDSLSKLRFSVLGVGDSAYDENWCLFPRN
VDTYVSEMAGVHIAKSVFADVGVSNGPSDLDAALADWTGACIKSLLAMQNGMGYSADGST
TEESAPTVVDEFEVLDEEYVTSDEEAEDGFDGVIGDGSDAGGEVMDLEDLGAFASAGLKA
ARKAKEEDAAAAAAEDGNLVIRKKGAAAGAGNHTREMITPNLRKNLEKQGYKLIGSHSGV
KLCRWTKSQMRNNGGCYKHTFYGIESHRCMETTPSLACANKCTFCWRHQTNPVGVEWRWK
ADLPKDIVEGALEKHRAMIKQMRGVPGVTPERFQEGMDVAHCALSLVGEPIMYPYINEFV
DLLHEKSISSFLVTNAQFPELIRTLKPITQLYISVDAGTKESLKKIDRPLFSDFWERYNA
CLDEIAKKEQRTVFRLTLVKGFNVDELKNYANLVRRGKPDFVEVKGVTFCGYTGNNPLTM
ANVPFHEEVVDFVKMLAEEISDEYEISCEHAHTCSLLISHKKFKINGTWHTWIDYPKFHS
LVRSGAHFTSMDYLAPTPEWAVFGDNRKGFDPNMTRVYRNKAKYEGDPEGYKEKIRDAKL
AAAAAEKAAAAAAAEL
>A0A7J4PFG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinaceae archaeon|TrEMBL
MAEMSMENQNQDQSSGKPPLPFDIPDFKTLLKKQGYALAGSHSAVKTCLWLRKAMNDEGF
CYKGKFYGVASHRCLQMTPTLLCNQSCLFCWRPTEVPVPAPGEWDSPEKIVEESIACQRK
LITGFGGSPNALRERWLEGNDPNNVAISLSGEPTMYPYLPELIEEYEKRGFTTFLVTNGT
IPGMFAKVNPCQLYMSLDAPDLETYLKVCQPKSPALWDKISESLALMKEKSSRTVIRITL
VKGVNMFNPEGYAELIKKASPDFVEIKAYMHLGFSRLRLDRSAMPAHAEVLEFSEQVAKH
LGYEIADESEISRVVLLSKDGKKSPVRKKT
>A0A0Q4B0Y5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon RumEn M2|TrEMBL
MDKEYRALLEKQQYRIYRDHSAVKMCHWLKESLIHGRSCYKQDFYGIRSHRCLQMTPAIN
ECSHQCVFCWRVQGKDFEVREWAEPKEMLDALIEKQRKLITGFKGDDRCTKEMYEEARNP
NQVAISLAGEPITYPYLSDFLKECHSRGMMTFLVTNGTYPEKLEALDTLPRQLYVTVAAP
DRETYRKVCIPKIDDGWDRITRTLEMLPSLDTRTVVRHTLVRGWNMHSPEKYAELDRIAD
PDLIEPKGYVFVGGSRQRLSMDCMPSFREVQDFSDTIGSALGMEILKEKEDSRVTLLGRL
GIELDVTKLYNLQK
>H3G5B1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora ramorum|TrEMBL
VRILYGTQTGASKTMAKTLEKTLFALNISGFHFQTSVVSMKDYDQDNLEQEDIVVAILST
WTHGQPPEDARVFCNWITDMTQDFRVSKSWLGGVHHAVFGLGNAEYDDDYATAAKHLDRD
LVDLGSPSLVALGLGDDNVDQFKQFDVWMDNLVAALCEFSSEKAVAALNKSNGPVKAGKA
GKEWLSQKEFRRQKRAKKAEVAAANGEAVEMNEEDLMNEQFLVDEFSDDEEQSQPDANDD
SGMVDVEDIGKSMKESEAASKSLEMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRG
RGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSI
ERHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFL
VTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELRHKGQRT
VYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGF
CSALCDRVSGDYALASEHSHSNCVLIAKKKFCHDGVWHTWIDYERFHELVAKFYEDGTTF
TADDYTAPTPSWALFDSKEQGFDPVETRFRR
>A0A7K6QWA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Climacteris rufus|TrEMBL
LFVSMDTWSYFHTCLVSIWLHRVYIYSAVAFGISLWIVIRFTTTKTKKKVTEPGRAAKLV
NGCASPEAKEVHVAGVKIFYGSQTGTAKRFAKALAEAVISLNLPVEVINMGDYDPDDCLS
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKAFLQGLRYAVFGLGNSL
YLEHYNTVGRRIDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTRLQGL
CKGEKKPCSGKCKKGKCKSSGKQSKESSDHEQGTSEQENTEAEELFETSSEEEAGDANSV
IDVEDLGNLMGHMKKAQSSMETMVLNRFGDQLVCSVYQFLQVKLHCLMIFALFPGYKLIG
SHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGT
EWRWKMDQPEMILQEAIENHQNMIRQFKGVSGVKAARFEEALTVKHCALSLVGEPIMYPQ
INRFVRLLHKHSISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFW
QRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSA
SSLTMANVPWHGEVVSFVQELAQLLPEYGIACEHEHSNCLLMAHRKFQVNGEWRTWIDYG
RFQELVREHEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A3Q4HN08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neolamprologus brichardi|TrEMBL
PFISALICFQKNVSKDASKEKNDKVDKAAKKNDRETKKVHVSGVKIFYGSQTGTAKGFAN
ELSEEVKSLGLPAEVIDMKDYDPDDQLADECFSKSVCVFLVATYTDGQPTENAEWFCKWL
EEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDC
NVVKSLNGSIQADFLTWKVKFLNRLQTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKA
SPQNNNHNRLKVLFLPQSKEESQRDGQMVKLSKLNGVQKIEDEGERREMITPALREALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVG
EPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRYNLVPVTQLYVSVDASTQDSLKKID
RPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFIEVKGV
TYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHTKFKVDGE
WWTWIDYERFQELVQAYDESGGQQTFSALDYVAKTPSWALFGAQEQGFDPAETRFQRRNK
SKDISGC
>A0A315XIP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedenaceae archaeon|TrEMBL
MKETTSLPETTRSLLKKHGYHLAGTHSAVKTCLWLNRSIRNTGACYKSKFYGMTSHRCIQ
MTPTLVCNHRCLHCWRAVEVPVEIPTVWDSPDRIVNDVLMEHKRLISGYGGSEFMDKTRW
KEAFSPKHVAISLSGEPTLYPYLPELIEEFHKRDMTTFVVTNGTNPEMTEKIRPTQLYIS
LNAPDESIYEKACSPLGNSWENIQRSLEILKGSSTRTAIRITLTKGVNIIDPEGYARLIE
LAQPDYVELKAYMHLGFSRKRLLRESMPSHEEVLDFSRKVAKVLDYCIADDSSGSRVVLL
SKDGGKTLI
>A0A836J8L5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salix suchowensis|TrEMBL
MTIMPLTSTPARLTLLALLSATTVYCFYKSRRLKKISLNPNPNKPKLFFVSQTGTSKTLA
HRLHNLLASKNLHFDLIDPQSYEPEDLFKEKLVIIIASTWEDGKAPQNAKFFANWLAESA
GDFRVGSLMLSECKFAVFGVGSRAYGETFNALAKDFSRWLRDLGAKEVVGVGEGDVDAGE
LDMVFEEWSGRLARVLKGESVENGEVCGNGVVVIDESDDDEDDGGVESDIVDLEDIAGKG
PSRRSFVEAQSNGKLNGENGKLNGQKEMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVN
SAIDLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHRRRIS
TFLVTNAQFPEKIQMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLTEKQ
QRTVYRLTLVKGWNTEDLDAYFNLFSIGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDV
KAFSEALSLKSKGEYEVACEHVHSCCVLLAKTEKFKVDGQWFTWIDYDKFHDLVASGKPF
NSKDYMAATPSWAVYGAEEGGFDPVQSRYRKERHHKTTH
>A0A4Q9KYT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hamiltosporidium magnivora|TrEMBL
MSVNIFYATETNKSLKYAIKLSDALISKNIDVGVHSFDDYFYSEIALFITSTFYDGQVPK
NGRVFFKKLKIAAKNNDLEFKPPKFFAIFGLGSTAYLSLFNLVAKQIYGYLITLNSISML
SPVYSDEYGDMEAVFDNWVSNVCDSLTNNNYQTNQNPKSSEIIDTNNKPDVSDIEDLSLM
LTPSLSKNLKKQGYSLVGTHSAVKLCRWTKSMLKGRGGCYKNTFYGIISSSCMEATPNLA
CANKCVFCWRHYTNPVGTKWRWNADEPDKILKGMLEEQNKLINSVINGVKTEINKFKGVK
HCALSLVGEPVMYVHINKLIELFHKEKISTFLVTNGQFPDQMRALKDVTQLYLSIDAGDP
VSLREIGRPLFTDYWERLLECIDILKEKRGRTVFRLTLVKGINDETTDSNKEEQERNENI
LGGYISLIKRGTPDFVEIKGVTFCGWTQDSGLSMKNVPYHNDVINFAIQLINGLEGYEIA
CEHEHSCCILIANTKYKKNQKWYTWINFDKFNEDLQGIEYSCETPDWALFGSREKGFNPN
ETRYQRKKNQIK
>A0A8H3YY06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Venturia inaequalis|TrEMBL
MTLPLNLWELPQELLELWHDYRNPIILSVVAILTAVRIYLRFRAGREKLSESPIPGSPQS
LFDEKTEKLPTVVPGLEDDHVQDFTFVEPKRILRKTSPKRVTGKKLRPVASDAATFDHET
DSLQPLVFFSSLAGGTEKTAQEFVKNVSQWKDDADFAGIDRVLPAITHDLSYIEYDDYFI
NPPKDSKAKCFYIILLPTYNIDTVLDLFLEHLKETHNDFRIDTAPLSGLLGYSVFGFGDK
EGWPTEEEGFCSQAKEVDKWMAKLTGRKRAFPLGMGDVKGDSKERLEEWRLGVQEVLGDL
MSGKGLGEGVQGSGDAVESEDEDIEPELKSNLDDVEDLGRSYRNGQTTKAPLAVDFTTIN
KAKAPVSTVKEMVPKDSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYG
IASHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFEGVKAGHYKKIKMMK
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNAQHPEQLA
ALKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFIRCLDILKERRFEQRTVFRLTLVKG
FNIEDEAEGYADLVERALPCFIEVKGVTYCGTSTSSSAGLTMQNVPFYEEIQTFVIALNA
ALEKRGLAYGLAAEHAHSCCVLLASERFKIKGKWHTLIGYEKFFNCLESGKPFKPEDYVG
EPTPEWALWGNGGFDPRDERVDRKGRPKELNLGPRSVGRVVEI
>A0A8D1W5E5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGLFAAILAEAVTSLDLPVAVVDLKAYDPDD
YLLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRL
QALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESG
SEDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFK
IGREWWTWIDYNRFQELIQEYEDSGGSKTFS
>A0A6P8V8X5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gymnodraco acuticeps|TrEMBL
MDRLQRHNKTQNYTSRHSTKHGCTQHQLQMTFYLNTQLTATLSVFRVIMLCISSVSALET
EGSQNALSPGESYLLSVWHHRLYLYSAAALLFGXWFLLKVALNKKSFSKDVSPLVSKAVK
RSEGSDAVVHLPGVKIFYGSQTGTAKGFAKELSEEVKTLGIPAEVIDIKDYDPDDRLSDE
CTNMSVCVFLVATYTDGTPTVNAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYV
GHYNTVGTNVDKWLWMLSGMRIMTRGEGDCNVVKSHHGSIQADFLAWKVKFLTRLQALAK
GEKKSCSGNSKNGSSCKNMKKEQEEDEAAPVPQDNSSEEDLMESSSDEEESGLQDEKTSG
SVVDMEDLGNIMNSVKRAKSKEEGGDGLMVKLSKVNGLKKIEDEAERREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HNTNPVGTEWRWKMDPAEKILEDALEKHQTMIRQFRGVPGVKPERYEEGLAVKHCALSLV
GEPIMYPEINTFIRLLHTHHISSFLVTNAQFPKEIRSLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELISLGQPDFIEVKGV
TYCGDSPASTLTMANVPWHQEVVTFVQELADMLPQYEIACEHEHSNCLLIAHTKFKVEGE
WWTWIDYERFQELVQAQEESGGQQGFSALDYMAKTPSWALFGATEQGFEPVDTRFHRRNK
TKDISGC
>A0A8D1W418|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGLFAAILAEAVTSLDLPVAVVDLKAYDPDD
YLLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRL
QALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESG
SEDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESL
KKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFK
IGREWWTWIDYNRFQELIQEYEDSVDPPMRLPEQPGAGKPENEEKGGRGAPGGGEEPPRS
RAPDFPTWQVFSPKPLPEKQAFSNVYSGLDCFQPAGRGWCGGREPLCQMSGRWGEGEETP
WTRRPGRGSPGDAHPTGTEIWRFVLSFEP
>A0A1F5DFB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon RBG_13_38_9|TrEMBL
MQTSSLEHRLYKDDSSSTSNIDSNLLRVLKRQKYQIIGNHSAVKKCRWLHMGLVEGRSCY
KSRFYGIKSHRCIQFTPSTIWCTQSCLHCWRIQKGESNLSWDESTSEIWDTPSKIVDLAI
ASQKRILNGYRSQVLSGKIKSDVYQEALKPKHIAISLAGEPTLYPDLGELISEFHSLGMT
TFLVTNGTRPDVLKNLSDEPTQLYISLSASRSERYQKICKPRSKIYWQKLLETLNLLKSF
NCPSAIRLTLVKGLNLEDPQSYAKLISKADPTYIESKAYMYIGYSRKRLTFENMPTYKQV
REFSLKLAEFTGYRILDDSVESRVVLLSKLEKPIKVC
>A0A1Q7TTA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon 13_1_20CM_4_64_14|TrEMBL
MDPQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGIGCYKQTFYGIESHRCLQMTPAVD
ACNLACQFCWRTQEWGSNSLLAADDPAFIVDESIRAQRELLTGYKGNPNVTRERFLEAWH
PTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQLYVT
VAAPTAEIYRRLVAAKSDNEWRKLKETLALLPTLPTRTVVRHTLVEGWNLGWEDEYAELD
RLGKPMFIECKGYSFVGESRLRLQAENVPSHASIRTFAERLADRVGYQIAAEREDSRVVL
LTQDGALHPISP
>A0A5G2QAU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFS
>A0A8B7T593|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hipposideros armiger|TrEMBL
MDPSLDTWDFSPLIALWINRFYIYLGFAFGITLWICFQIVIRNQSFIFKDQNSQDKSVPK
ATRDLMTNGSTSFQKKEVFVSGVKIFYGSQTGTAKGFAAALAEAVSSIDLPVAVINLKEY
DPDDHLLEEVTSKNVCAFLIATYTDGRPTESAEWFCKWLEEASNDFRFGKTYLKGMRYAV
FGLGNSAYASHFNKVGKNVDKWLWMLGAQRVTTRGEGDCDVVRSKHGSIEADFRAWKAKF
IFQLQVLLKGEKKPCNCNCKKGKCESRQPGSEEVEPGSHAQDGLQQGDTEEGPFESASAD
ESGPEDQPSVPSVVDVEDLGTIVSRVRKEKRAKAQQEDKAGLFGNAVTNEASERRAMITP
ALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVREQRFAEGMMVK
HCALSLVGEPIMYPEINRFLKLLHKCKISSFLVTNAQFPVEIRNLTPVTQLYVSVDASTE
GSLKKIDRPLFKDFWQRFRDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPD
FIEVKGVTYCGESSASSLTMANVPWHEEVVRFVHELVGLIPDYEIACEHEHSNCLLIAHK
KFKIDREWWTWIDYNRFQELIQEYEDSSGSKTFSARDYIAKTPHWALFGANERGFDPKDI
RYQRKNKTKDISGC
>G0V5D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630)|TrEMBL
MSFNIVTTVGVVSSVAVYYFYFSGRFTVSLTVLIAYAIFYSESNEKHKEGNAAHPITPVK
KEKKACCCSGKKEGEKKKSGSGSCCSGKKNGSGGGGCCSTKKLIDVDQNEIPQEDDSMTI
DFTTAFLEKKSKKVKKVPKIFSAAKPDSVAPASPKQKEIEPTEPAQDNFIRSALTISNET
MLNSQIYVFYSSLQGSGERCAKIVHETLTAMPELAHQPKLLNLDELNDIDEYFVDVPCEN
ALYVLVVPSYDVDCPLDYFLQTLEENFNDHRIDGFPLRKLVGYCVLGLGDSESWPEKFCY
QAKNTDHWIARLGGRRVFPVGEVCMKTDGVNKVTEWANLLAETLKDDEPIIYEYDETCDI
EEDAGADYASDGSDDEGLADVEDLAGKEATSKKNSNSMETKQMVSKDSPTYRNLTKQGYR
IVGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCWRHGTNP
VSKSWRWETDDPEYILENALKSHYAMIKQMRGVPGVIADRFTNAFKVGHCALSLVGEPIM
YPHINRFVELLHEKEITSFLVCNAQHPEALENIGKVTQLYVSIDAPTRDELKKVDRPLYK
DFWERMLQCLDILRTKQSHQRTVFRLTLVKGFNIGNISSYADLVQRGQPCFIEVKGATYS
GSSDGNGNPLTMQNIPYYEECTTFVKKFTEELQRRGLNYEVAAEHAHSNCILIANTKFKI
DDEWYTHIDFAKFFENLNSGKNFTYMDYMSKTPEWALFGNGGFAPGNTRVYRKDKKMKNK
ENLNVATENTVETSAEVSVNA
>A0A7J3AZM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MLALGVSTPSHVRKLMEKQGYKFILNHSAVKPCYWFRKSIMEGKTCYKNKFFGIPTWRCI
QMTPTASFCNMQCVYCWRLNASDVPMSQRWVEVPEGKWDDPEEIAEESVRVHRMLVQGYK
GVRVFNKDWVREAEEPKHAAISLTGEPTLYPFIGGLVEAFSKRGMTTFIVTNGTMPERIE
GLEREPTQLYVTVPAPNEKLYAEITRPIWPDAWNRLMRTLELLQSLSCPTVIRIPLMKGL
NMDERTLEEFSELIKRYQPTYVEPKAYEWVGYSRRRLNKWNMPWHHEVREFAYRLSDLTG
YKILDESEESGIVLLSRLERAIRFY
>A0A328RXS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. SHI1033|TrEMBL
MLISEKKQKDLEKKGYRFAGDKLHAANKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PSVPYCQNKCLFCWRDTEITKTSWDTDDYDDPKTIIEDCIKNQKQLLCGFFGNDNANPKK
LEECVKPNNAALSLAGEPLLYPEINQLIEEFHKQDFTTFLVSNGESPEKIQALEDHEPTQ
LYLSLDAPNEEIYRKVCKPQVNNSWQKLQESIELLSSIDTRKVLRITSVKNLNMTHASEY
AKIIENSDIDYVEIKAYMFVGDSRNRLEWENMPKSVDIQKFAQDVADETSMEIIDEVEKS
RVLLLGDKKPRKYNN
>A0A842MTS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPSQLIEALKKHRYHLVGQHSAVKRCRWLYESIVNNRVCYKQKFYGIKSHQCVQMTPSLF
YCTQRCLFCWRAQSGDLQLSWEETSLPQWDNPEDIVDGCIRAQLDILSGYKGNPKADPEK
LMEALRPRHAAISLTGEPTLYEPLGELIRAFHKRGFTTFLVSNGTVPSSLANLSEEPTQL
YISVCAPNEEVYRRVCRPIIPKAWEKLNASLELLSSFSCPTVIRITAVRGLNMGNIEEYA
RLIAKANPTYIEPKAYMHVGFSRLRLKYENMPTHNEIKEFACKLAAETGYNVIDESEESR
VVLLSKYKRAIKFTETNPKEG
>A0A7C4XRJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLVPDALIEALKKHRYHLVGRHSAVKRCRWLYESLVHGRPCYKQKFYGIKSHQCVQMTP
ALFYCTQRCLFCWRAQSGDLQIIWEEAKLPVWDPPEEIVEGSIKAQLAILSGYKGNPKAD
PQKFREALRPRHAAISLTGEPTLYGPIGELIHTFHKRGFTTFLVSNGTVPSALAKLSHEP
TQLYVSVCAPNREIHKKVCRPILPDAWEKLNETLELLQSFSCPTVMRITAVRGLNMGNIE
EYARLIEKANPTYVEPKAYMHVGFSRLRLGYGGMPSHEEIREFAFQLAEATGYKVIDESE
ESRVVLLSRLEKPIKFSSD
>A0A650A0S1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorhabdus sp. CBA1104|TrEMBL
MSDQARQVSDPDYHSEGHTAAQTCGWTDNALQGEGQCYKYAFYGIRSHRCIQMTPVVRCN
ERCVFCWRDHAGHTYELDDVQWDDPEAVVDASIALQRKLLSGYGGNSEVPRERFEEAMEP
RHVAISLDGEPTLYPHLPELIEAFHDRGITTFLVSNGTDPEMLAKCEPTQLYVSVDGADR
RTFDDVVKPVEDEAWGRLIETLDVLAAKDDTRTVLRTTLIDGYNMHRPAWYAGMAARADV
DFYELKAYMHVGHSRGRLDRSAMPDHADVIDFTEAVGEHLPEHDVIKESADSRVAMLARK
EDTWVEKLAPESDFWEQEAADWTPKGGRP
>A0A8J7ZM37|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halostella sp. JP-L12|TrEMBL
MSDSEDGPAQVGSPNYHSENHTAAQTCGWTANAMRGDGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQKKLLSGFGGNDEVPDEVFEQA
MEPRHVAISLDGEPTLYPYLPELIEEFRERDITTFLVSNGTNPEMLERCDPTQLYVSVDA
PERHTFDEVVKPVDDGAWEDLVDTMDVLADKDDTRTVLRTTLVKGENMRDPDWYAGFYQR
ADPDFVELKAYMHVGHSQGRLDRDSMPDHEEVMAFAGDVAEHLPEHDEIRGVPESRVALV
AREKDTWVPKLKKGSEFWERDPVVGD
>A0A2U9IG39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus brierleyi|TrEMBL
METPKLRIDTLSKIMSEMEKEKYHIIGSHSAYKKCYWTHKALTENRYCYKGKFYGIESHR
CVQMTPVAAWCWFRCIHCWRLEPEDIGVEWDETKMPIMDDPEYIAEKSIEEHVKAVSGYY
GRQGVKQAMIKDASKPAHVAISLTGEPTLYDKLGELISEYHKKGMTTFLVTSGVRPDILA
SLEEEPTQLFVSLQAPNEKKHKLINRPIVANSWNLVMETLKMLPSFSSPTVIRMTMIKGF
NMGIEDAKEFANLIKLAMPTYIEVKAYMHVGPSTYRLSKDAMPRHSEIREFAETLSKFTG
YKILSEHIPSRIVLLSKLEKPIQIGNAWTQKWSWSTKDSEDDINGEYKEAELGCTEEQ
>A0A7L0HFD5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arenaria interpres|TrEMBL
LDVSMDMWNFFYTCLMSLWLHRFYIYSAVASGISIWIAVQFFTTKTKKKVTEASEGTEDK
LVNGYGTLQAKEVYVAGVKIFYGSQTGTAKKFAAGLAEAVISLNLPVEVISMGDYDPDDC
LAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYAVFGLGN
SVYVDHYNTVGRSVDRWLWMLGASRILTRAEGDCNVAQSKHGSIEADFEAWKAKLLSRLQ
VLCRGEKKPCSGKCKKGKCKSSRKPSKESSDHEHGASEYENTEAEELFETSSEEETDAEE
AGGTNAVVDVEDLGNIMSHVKKAKVPLLDRVLMRENTGRKEEGEKREMITPALREALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEMIFQEAIENHQNMIKQFKGVSGVRADRLEEAMAAKHCALSLVGE
PIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTRESLKRIDRP
LFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFVEVKGVTY
CGESSASNLTMANVPWHEEVVGFVQELADLIPDYEIACEHEHSNCLLLAHKKFKVDGEWW
TWIDYGRFQELVREQERSSGCKTFTAADYMAKTPRWALFGSRERGFDPLDVRYQRKNKAR
DISGC
>A0A1Y3DR62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium knowlesi|TrEMBL
MVQGDDEKKRRNLLQTIFEQHAVRKRKKAKINLRIVYGSEGSNSYRKARGFLKELIQFFK
DIENICNEVNRIVSEEGGSHPIFFNGRTNEVDHGENRLMRYFKEYSKLLQGKNEQTARTG
KKDKFHTEGVINSVHEVLEEFQEKEKKCSDKFVNYLDCCISNNVCTVNFDFVNGNEFNDY
SFFEHTTEYDLNVMVLFVSTASNGSFPRNCYKFEQLLEDLYNDFRVEKNFLKNIFYTCIG
FGNKQYGSTHFCTPVKKCDKYLTSLGAQKLFKTLKLCDEENNEEVFLVWKCTLFKTISLG
LLFYCFNFLHLGSFMPYADRKIYNSLQHYCFFFCGKAENRKGKKENIKMGTTHAASIQVP
QEHGNQIHETVQKGESSQAGDPLTGIVPKGDPSTKVLCSTCGEGTSDRCTSDRCTNDGYT
HLNGDEWEGMPTTEKSEDEMVEKSTHTYKKKEDLKISTSLCSSGEELEDLVPDKPKDMLT
WNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGCYKHTFYGINSYQCMEATPSLACA
NKCVFCWRHHKNPVGTHWKWNKDDAEMIVDEALKKHKGMIKELKGAHGVIKERFDEAVNV
RHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNAQFPNELQKLHKVTQLYLSIDAPN
EEALKNIDRPLFKDFWDRYIRCIKILKKRKERTVFRFTLVKEYNMMSEEILSYSKLIEYG
YPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAYSLIHSNGYLPDVYEIACEHRHSC
SILIAKKEFKINDKWHTWIDYEKFQFLVKQNKDFTALDYCAETPAWAVMGAEERGFNPCD
ERVYTKGKKKNKPPITENTSQS
>A0A1Y2E0J9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudomassariella vexata|TrEMBL
MASQSWTTRLHAVGPTAYLIDVWHVYRTPILLGTVCILITLYVYLLLTQDREYSVVLRKI
YAEPASEKTEPRFTDITEKPSLPPAKESLSGPRRIKGEARKTSIRKPETPSVASRHIQPL
IFFSSLTGSTERIAEGLAQTLEASLGEYNTDNATFLKTQVLDLAEIDHDEYFISPPKHAD
SNVPVDYFYLVLLPSYNIDTTNDNLLEHLSETHNDFRIDTAPLSGLLGYSVFGLGDRENW
PTEDEGFCFQAKEVDKWLAKLTGRKRAFPLGMGDPKQDLTTRLNEWTEGIKDVLALIAKT
GSLGEGVPGSGDAVESDDEYASGNEDDGEVVFDEPTKPKISKKTKRSGNLDDVEDLGMMI
KSTKADRNRSSGAAPIAVDFTTYSKTTKKPAVTVKEMVPKNSPTFNSLTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPELIFNGVRAGHYQKIKMMRGVPGVRAERFVEAMRIRHCALSLVGEPIFYPHINE
FLAMLHEERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERF
QRCLDILREKRFKQRTVFRLTLVKGFNVDDEVEGYADLVERGLPCFVEIKGVTYCGTSSS
AGAGLTMANVPFYAEVTEFVTALNGKLRDRGLEYGIAAEHAHSCCVLIASERFRVGGKWH
TKIDYQKFFELLEARGADGDWTPEEYMGEETPYWATWGQGGFDPRDERVDRKGRKIVAP
>A0A2E9M2F1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPQIAQRLAKQSYHLVGEHGGVKVCHWTKQSLTADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLNKIDDDPYDLFLQSVRAHRRLLTGFGGHPSVPREKWLDAQDP
KHVAISLNGEPTLYSRLSEFLEICHNHGVSTFLVTNGSLPKVIENLDTLPTQLYVSVDAP
NKEIFNRICKPKFDTNAFSKLEQTLELLPSLDTRTVCRHTLIKGESLGYHEDYARLDNIA
DPMFIEAKGYVHVGKSQNNHTIENMPSHPEILEFSNKLASLTGREVLSDRRESRVALIGR
EMMPVVLPDKIINLPSDLGIAKPQNFHLPQV
>A0A2D7T8N6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDERLKARLQNQRYHLVGEHGGVKVCHWTKESLLRDRMCYKGKFYGVESHNCLQMSPVVD
QCNLACSYCWREPHMDTLELTDQDPLELLHESVRAQRRLLSGFGGNDKVNKEKLADAQNP
KHVAISLNGEPTLYRRLGEYIDECHKHGMTTMLVTNGTLPKVLEKLDPLPTQLYVSADAP
NKEVFDRICKPKWNNGAWHKFEETIDLLPSLDTRIVVRHTLIKGENMFGYEEEYAKIDER
AQPNWIEAKGYVHVGHSQNNLDITNMPYHDEILEFSNTLANLTGLEVLDDSKPSRVALIG
KEKIPLPIPEIVKEFPKDLGIAPPIKHLPLV
>A0A397SK48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glomus cerebriforme|TrEMBL
MTANESSKILIKIFYATQTKTAKYFAQQLHESFTKHSNCECTIMDIVDYETEDFLSELAI
CIFIISTYNVEGPLDWFYKWLEDTRYDFRVDKQSLSKMRFAVFGLGDSAYGDQFCIQPRN
IDKWLGQLGANRLYPLGESDKNSDQEKSFEAWKISLDDVLFDPSYGLNNVSTNPNYDSYS
ESDDELDSDSNNNNDSDTEMVDVEDMGALAPKLQAARKSKEEEVYKNHNGQPKRILTVQE
LPVKEPKEMVTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSHR
CLETTPSLACSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLNNHYKMIKQMKGIPGI
RADRFQEAFNVRHCALSLVGEPILYPHINEFVKLLHEKHISSFLVCNAQHPSRLRALDKV
TQLYVSVDASTKESLKKIDRPLFKDFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEIA
NYVELVRRGKPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFVEQLNQNLGETYEIAT
EHSHSCSILIANTKFKINNKWYTWIDYDKFFELIEKGEHFTSLDYIAPTPSWALFGSPEA
GFNPEDQRFYRKSKKNNNSVKNGGC
>A0A8C4EU73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
INKGFTTIIQSIQGKVLDQDTCIYKYLFCCTNKAVCVFLVATYTDGQPTENAEWFCKWLE
EASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCN
VVKSRNGSIQADFLAWKVKFLNRLQALAKGEKKTCSGNCKTGGSCKNKRKEGHEQEEEEE
EESSSDEEESGLQDEKKSGSVVDMEDLGNIMSSVKKAKLSKMNGLKKTEDEGERREMITP
ALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDPAETILQDALEKHQNMIRQFRGVPGVKPDRYEEGLAVK
HCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTK
DSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKSWNVEEMQAYSELIALGQPD
FVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLTDMLPQYEIACEHEHSNCLLIAHT
KFKVDGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPSWALFGAHEQGFDPADT
RFQRRNKTKDISGC
>A0A8D2M5A1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zonotrichia albicollis|TrEMBL
MDMWSYFHTCLVSIWLHRLYIYSAVALGISLWIVIHFTTTRAKKKPLEKGEQSRGSPSAP
EGASDKLGNGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEVINMED
YDPEDGLVEETSSRNICVFLVATYTEGQPPESAMWFCKWLEEAANDFRVGKSFLQGLRYA
VFGLGNSAYVDHFNTVARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDK
FLTRLRALCRGEKKPCRGKCKKGKCKTPGKQSKESSDREHGTSEQDDTEGEEMFETPSEE
EAGDTNSVIDVEDLGNIMGHMKKAKREQELQEGAAGAERREMITPALREALTKQGYKLIG
SHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGT
EWRWRMDQPEQILQEALEKHQSMVRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPH
INQLVRLLHQQGISTFLVTNAQFPEEIRKLEPVTQLYVSVDASTRESLKRIDRPLFKDFW
ERFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKVSCTELF
>A0A8B9BQZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anser brachyrhynchus|TrEMBL
MDMAEPPPRLAAPHGPAGEGGERRGRPAVHGRWPPRRRPRPVVGRQMASGGKRKGRGRGA
GAAAAWGRRAEAVALRKYFLPFLGTEPALDLDVSMDMWNFSYTCLASLWLHRFYIYSVIA
FGISLWIVVQLFTTKKKGEKSNGNLSSEVVEEKQANGYAALQAKEVYVAGIKIFYGSQTG
TAKRFAKGLAEAVTSLNLPVEVISLGDYDPDDCLAEETTSRNICVFLVATYTDGQPTESA
AWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIM
TRAEGDCNVAQSKHGSIEADFEAWKTKFLNCLQALCRGERKPCSGKCKKGKCKSQGKQSK
ESSDHEHGAAEYENAEAEELVETSSEEEADAEEVGGTNSVIDVEDLGNVMSHMKKAKRER
ELEEGVVGTSLSGETAGRKEAGEKREMITAALRDALTKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQE
AIENHQNMIKQFKGVSGVKSDRFEEAMTAKHCALSLVGEPIMYPEINRFLKLLHQHNISS
FLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQ
RTVYRLTLVKAWNVDELKAYADLVSLGKPDFIEVKGVTYCGESSASSLTMANVPWHEEVV
RFVQELAELIPDYEIACEHEHSNCLLIAHKKFKVDGEWCTWINYERFQELVREHERSGGS
KTFTAADYTARTPRWALFGSSQRGFDPLDVRYQRKNKAKDISGC
>A0A7K4NDM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSGEVIEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEDIITKLMAERKKLIM
GHYGDPNQDKKKLDESLLPSHYSISLSGEPTMYPKLPALIKHLKSFEATKSIFLVTNGQE
PDMIQKLGDENALPTQLYLSTNAADYESFLKINRPRYDDSWERWNRTLKMLSTLDTRTVL
RITLIRGYNDDEEMIPAFASLLQKSNTHFVEIKSYMHIGRSTNRLEHSDMLEMSEVRSFA
NKLAQENSDFTVMDESGISRIVILQNKKRFVDRFIPACC
>A0A497JFW4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon|TrEMBL
MLEEWKLARLCRAQYRVVGNHSAVKICHWTKEAIRGHAPCYKQTFYGIKCAQCLEMSPAI
TCNQRCLHCWRDITIFSKGWKGPIDDPKDIIKGCIEERRKLLIGFKGNKKVDQELLERAL
QPVHAAISLTGEPCMYPRIAELIDEFFNSGFESVYLVTSGTVPEALQKLNKLPTNLYISL
TASNPKMYKELCRPVISDGWERLQKSLEIMSKIKTNTVIRITMINRLNTENPSEFIPHIE
KARAKYVECKAYMHVGYSKERLTEQHMPSMEKIREFAKVIEENSNYEIKDERADSRIVLL
ERR
>A0A2T9WLY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobus sp. SCGC AC-742_M05|TrEMBL
MEVRAEEDVYRLLDQRLIKQGYHLVGRHSSVKKCYWNHAALVEGRFCYKGKFYGIESHRC
IQLSVTNHWCWNACLHCWRLRPQDVGIQWNETRMPFADDPRSIVEGAIREYRRIVSGYKG
RPGVDLKMYQEATNPKHVAISLTGEATLYPMLGELIKEFHRRGITTFLVTRGVRPDVLAN
LEEEPTQIYVSLEAWDKESYNYFNRPLVPRAWELTLETLQLLPSFSSTTVYRITIVKGFN
DNDAALRGFAELVKLGMPDYIEVKAYMYVGASRNRLRLENMPRHEEVKAIARKLSELTGY
PVVSESAPSRVVLLSRLERPIRYGNAPVDWNSPDIPAPGEYEEPNEAATA
>A0A2Z5PU91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis KA1|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
FEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCLRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILSENSIFKIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A7I8K7Y0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spirodela intermedia|TrEMBL
MASTPLSARFALLAFFSLSSLFFIYKSRRARHLRLASLAASLRGDEAARRGKVFFASQTG
TSEALARRLHGFLQSEGLAFDLVDARNYEPEDLQKESVVLLVTSTWEDGRPPPNAEFLAR
WLSESADDFRVGSMLLSRCEFAVFGVGSRSYGEGFNAAARSFARWMRSLGAFEVLPVCEG
DVDAGDVDEIFRAWSRNVVQLLQGEFLAGGPPFSKSEDGALVGSVEEYESEDEDEDEDEM
VESEVVDLEDIAGKAPPVKLTVGSRNGGSNGVKKTAANGNMNGMKEMVSPVIRTNLEKQG
YKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWQWKMDEPLEIVAAALDQHIKMIKQMKGVPGVKEEKLLEGLSPKHCALSLVGEP
IMYPEINSLVDELHRRQISTFLVTNAQFPEKIRTLRPITQLYVSVDAATRESLKAIDRPL
FGDFWERLIESLKALREKEQRTVYRLTLVKGWNVEDIDAYLKLLDIGEPDFIEIKGVTYC
GSTATSKLTMENVPWHSDVKAFSEALSQKSGVYEVACEHVHSCCVLLAKSDKFKVNEQWH
TWIDYEKFQDLVASGQSFRSTDYMAPTPSWAVYGAEEGGFDPHQRRFKKERRHGAAALSR
>A0A667ZE19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
LFLKSLSFYLLSGRPTSPLYIIEFLCSVVSLILLVCFDLLAVQCSNKSVCVFLVATYTDG
QPTENAEWFCKWLEEASTDFRYGKTYLRGLRYAVFGLGNSVYVGHYNTVGKDVDKWLWML
SGMRILTRGEGDCNVTKSRNGSVQADFQAWKVKFLSRLQDLAKGEKKSSTGSCKSGSGSC
KSRTKRSQGQSEEEKAALHDNFELVESSSDEEESALPEESQSGSVVDVEDLGRIMNSVRK
AKVRDGQMVKLSKVNGVKKIENEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKS
MLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKIL
QDALEKHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRI
SSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEK
RQRTVYRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQE
VVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSG
GQRSFSALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A667YKS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
NSGVLVRPPEGCLMSLWHGRLYLYSAVALGFGIWLSLQVAFKKKSFAKQVGPWVCKAVRT
SGPSQEKDAVLHVSGVKIFYGSQTGTAKGFAKDLSDDVKALGIAAEVIDMKDYDPDDRLA
DECSNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLRGLRYAVFGLGNSV
YVGHYNTVGKDVDKWLWMLSGMRILTRGEGDCNVTKSRNGSVQADFQAWKVKFLSRLQDL
AKGEKKSSTGSCKSGSGSCKSRTKRSQGQSEEEKLVESSSDEEESALPEESQSGSVVDVE
DLGRIMNSVRKAKSRDEGRGDGQMVKLSKVNGVKKIENEGERREMITPALREALTKQGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNP
VGTEWHWKMDPAEKILQDALEKHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIM
YPEINAFLRLLHTHRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFR
DFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGE
SSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWI
DYERFQELVEAHERSGGQRSFSALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDIS
GC
>A0A8J7QUU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Brockarchaeota archaeon|TrEMBL
MLPEKIQKLLEKQKYRLVGTHSAVKVCYWTKQSLTTGRVCYKELWYSGVKSHRCMEMTPF
LGCNYRCSYCWRIHSDDRPNYPWKEFPVELQKIDEPNFIIDEAIRQRKKLLIGLKGNPKV
DVKKLEEALEPTMLTLSLTGEPTLYPMLDELINEGNRRSMTTFLVTNGSLPEVLERLNNL
PSQLYVSVSGANKETYLMLARPIFKDAWERFNKTLELLPSLNTRKVLRLTMVKGYNMKNP
ELYAKLIEKAKPTYVEVKAYEWVGESQRRLPKSAMPYMEDIMSFAEEISKLTSYSIGGAF
EPSGVVLLKK
>A0A328PFQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter tenebrarum|TrEMBL
MDVFISKFEKLKRLERMGYRFVGKNAHTAVKTCLWTKKSILDEGTCYKQKFYGIKSHRCL
QMSPSVFFCQQKCLFCWRDLRYTKTEWDGDYDEPADIVDECINAQRSLLCGFFGNEKANK
EKLIEAQEPNNAAISLAGEPLLYPMINELIREFHKRKFTTFLVTNGINYKALESLSEEPT
QLYISLDAPSKKIHKKLCRPQTENAWEHLNRSLELLPTFNCRKVLRITAVNRKNMTKPSA
YASLIKKAQPDFVEVKAYMYLGYSRQRLEMENMPLFFEVYEFADKIAKLANMDIIDKSKE
SRVVLLS
>A0A7K9ASR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dromaius novaehollandiae|TrEMBL
LDVSMDPWNFFCTCLMSLWLHRFYIYSSVAFGISVWICIQFFTSKTRKKVTEHLSLFLTE
DKLVNGYATLKAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLSAEVINMGDYDPD
DSLTEETTSRNICVFVVATYTDGQPTENAAWFCKWLEEAANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSR
LQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDREHGASEYENTEAEEFFETTSEEESNA
EEAGDTNSVIDVEDLGKVMSHMKKAKVLVVQQMHFVNQLLQVKSNSLIYFLFSGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEI
NRFLKLLHQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQ
RFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSAS
NLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKIDGEWCTWINYDH
FQELVRDYERSGGSKTFTAADYMAKTPHWALFGSRERGFDPLDIRFQRKNKTKDISGC
>A0A3R7BYL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MEQKATLNYNEETLRTLERQGYHFVGTHKHSAVKTCLWLWKSIRGEGNCYKGKFYGISAH
RCVQMTPSIFCNQRCIHCWRPIEAFNVEPRIVWDPPDEIVEGSIREQMRLISGFKGSPRT
DMAAFNEATKPKHAAISLIGEPTLYPYLNELIAEFHARDMTTFVVTNGTNPDVVREIKPT
QLYLSLNATEEPGYKKVARANYWARIMDSLEELRRKSCRTVIRITCMEGLNMENPEGYAE
LVKKANPDFVEVKAYMHIGYSRKRLSRAAMPAHARVKEFASEISNYLTAHRIVDESEISR
VVLISNSSIRKRNKMQPVNVFFF
>A0A445DLK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arachis hypogaea|TrEMBL
MPSALSSFPARVTLLALFSATTFYFLYKSRRLRHLKTLTLSSKHTTRGKILFVSQTGTSE
NLAQRLHNLLASNGVVFDLVDAQSYEPEDLPKETLVLIVASTWEDGNPPSGARFFATWLA
ESVKDFRVGALLLKGCRFGVFGVGSRAYGERFNAVAKGFVKQIRDLGGSEVVPLGEGDVD
GGELDLDFEKWCEKVVGFLKGKVLENGVNGNLECGVYDSEEESEGESDLEEEEIVDLEDI
AGKVPPRKKTAAAAESNGNGNGKVNGQREMVTPVIRANLEKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPIEI
VNSAIEMHSNMIKQMKGVPGVTLERLNEGLTPRHCALSLVGEPIMYPEINTLVDELHKRR
ISTFLVTNAQFPDKIKSMKPLTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKE
KHQRTVYRLTLVKGWNTEDVDAYYKLFSIGEP
>M4B6J8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyaloperonospora arabidopsidis (strain Emoy2)|TrEMBL
MLSPAASAGVSLLLVATSVLLYLSVQLRPLSIDAAAISCKKKAKKSSSCKPKSDPPQPLT
VRILYGTQTGVSKTMAETLQKSLFALNIANFYFQTSVVNMKDYDQDNLEQEAIVVAILST
WTHGNPPEDARVFCNWITDMTQDFRVSKSWLNGVPHAVFGLGNAEYDEDHATAAKNLDRD
LSNLGSPSLVGLGLGDDNVDQFKQFDIWMDNLIAAMCEFSSEKAAAALKEGGNGVKDAEK
AGKKEWLSQNEFRRLKRAGKVKAAAANGESVEPNEEDRMNEQFLVDEFSDDEEQNAQSTN
DEDGMVDVEDIGKSMKESEAANMSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQL
RGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKMDDAETLVKG
SIERHQSMIKELKGLPGLIPARWEEAFTVRHCALSLVGEAIMYPQINEFCRQLHNRHISS
FLVTNAQFPEKIAALDPITQLYVSVDAGTKESLRAVDRPLFKDFWERFLACLEELKHKGQ
RTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSNLTMKNVPWHEEVR
GFCSALCGRVSGDYALASEHAHSNCVLIAKKKFCRDGMWHTWIDFPRFHELVTKFYEDGT
PFTADDYTAPTPHWALYNSKEQGFDPVETRFRRTRDGKVVEFAYQSTESGCG
>A0A0G2E1S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diplodia seriata|TrEMBL
MASNDSFQAVSSDLLSLWHTSRVPVLLTVCAVIAFARLFQRLRQPRQKLSASPIPGSPTS
KVDEIAAPWANTENIPTVPEKAAELLDDGHVEDITIAEQPLARPKAGPKKVTGTKLPRQA
AKRVCSFDAARDHVQPLVFFSSLGGTTEAAAKKVVDEINQWIYALGSDGIPRPLSPQILD
LAEIDYDDYFISAPKGEKNVKYFYLVLLPTYNIDSMLDNFLEHLQETHHDFRIDTAPLTG
ILGYSVFGFGDREGWPTEEEGFCSQGKDVDKWLAKLTAKKRAYPLGIGDVKSDAQDRLKE
WRLGVQDILLDVCAGKGLGEGVAGSGDAVESDEEDIDDDEVDSETAQPTKPKKTKAKSSL
DDVEDLGKMVKSEIDPDEPMEVDFTTYKKPVKAAAPAAPKEMVPKSSPTYSSLTKQGYTI
VGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPEKIFEGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINEFMAMLHKEHISSFLVCNAQHPAQLATLKQVTQLYVSIDASNKESLRKVDRPLNRD
FWERFCACLDILREKRFQHRTVFRLTLVKGFNMADEIAGYADLVERGLPCFVEIKGVTYC
GTATSAAAGLTMQNVPFYAEVQEFVEALNQELNSRGLEYGIAAEHAHSCCVLLASTRFRK
QVDGEWKWCTLIDYDRFFQLLESGEDFKPEDYMGEPTPEWALWGNGGFNPEDERVYRKGK
NKDKAVQAAPKPIVEI
>A0A4E9EDI0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella zeae|TrEMBL
MSGCNSTTSTGTVQAACNGSTPNPCESNLPCKEETGWRRVIRNFTPSWFAVNMGTGIVSI
LLHNLPYNAIWVQYISYIFFGLNVVLFTVFTALSIARYTLYPTIWSAMISHPGQSLFLGC
FPMGLATIINMMVFSCKHWGDWVIYLAWSLWWFDVWVSVATCVSMPFIVMHRHRPGLENI
TAALLLPIVPAVVAAATGGIVAEELPNHHQALTTVIASYVLWGIGESFSAIVLALYFHRL
TIHSIPPKEVIVSVFLPIGPLGQGGFGIQQLGKVAMHVVPKTNAFGEVAVRAGEMLYVLG
VFFGIVMWGFALVWLSFALISIAMMPNVPRNLGAWGYTFPLGVLATCSNALAENLDSDFF
KIATMIISLAVVVLWVVVAARTLKLAITGEMFHAPCLKDLREKLIITMDWANHSSPSRLD
SFVDELVDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKAYEEPAKPKVAVEE
VKVEHVEIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEEKDISRPVVPFVFF
CSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFDDYFLTPYKEYGDA
DLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDKENWPTEAD
GFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEEVIEYVARTGSLGE
GLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVEDLGRMIRKDDGSTV
QKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVGSHSGVKTCRWTKS
ALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIF
DGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPYINEFLGMLHAERI
SSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFWERFNRCLDILREK
RFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSMSNV
PFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDEKWHTLIDYKKFFE
LLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEAS
>A0A6G3LGL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcales archaeon|TrEMBL
MKKQGYYFANEHTVLKTCSWTRNALTQKRFCYKCKFYGIESHRCIQMSPAAFWCWNACVH
CWRLRPQDVGLSWNETRMPDFDGDISELVDRIIEGQKRLLSGYKVHSKVEQRMFEEAMNP
KHVAISLTGEPTLYNKLEDLLKEFHKRGLSTFLVTRGVRPDVLLNLQEKPSQLYISMEAY
NREMYEWLNQPLVPRAWEKTMETLRGLPDYGRPTVLRITLMRNINMDDNAIKGFSKIIDI
MQPTYIEPKAYMYVGASMLRLTKENMPTHEEVMSFAEKLSKETGYPIRSESKPSRIALLS
KLEKPIRFGKGCPGGWSGPD
>A6ZW48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain YJM789)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A4Z1K0C2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis elliptica|TrEMBL
MPSDSWISRPIWSYEIDDIVALWHLYRIPIILTTATILILVRITLRPRTVREKLSASPLP
SSPVLPAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQSGPEKIQPLVFFSS
LTGTTEKTANSFVESIRGDLSGRATGQKIQFLESRLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTTGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGEDKVAENSTKDEFSF
>A0A484N4H4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuscuta campestris|TrEMBL
MPPSLSALSTRLAVLSLLSATTIYFFYKSRPHIRHLRNRLKALTGLPARNPNHSSRGKIF
FLSETGTSRALAHRLHSFLALSDLPFDLIDPKDYEPEDLHKESLFLIVASTWESGKPPSN
GRFLGDWLTESSDDFRVGALLLCNCKFSIFGVGSTSYGETFNAVAKDFSKRLRKLGAAEV
MEVCEGDVDEGNLDDVFDDWCKRLAIILKGDSRPYFSNNGNVEESDGEVSEHDDYDSEVE
ENGEDKGIVDIEDIAGKTIAGTRAKNGMVNGETLNKEKEMVSPVIRASLEKQGYKIIGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
RWKMDDPLEIVQTAIELHTKMIKQMKGVPGVKSDRLAEGLSPRHCALSLVGEPIMYPEIN
SLVDELHRRRISTFLVTNAQFPERIMMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWER
FLDSLKALKEKQQRTVYRLTLVKGWNTEDVDAYSNLFSIGNPDFIEIKGVTYCGSSATSK
LTMENVPWHSDVKEFSEALAKKSNREYEVACEHVHSCCVLLAKVDKFKINGQWFTWIDYD
KFHDLVASGRPFSSGDYMAPTPSWAVYGAEEGGFDPDQSRFKKERHHNRSAPS
>A0A8C7YCX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias sinensis|TrEMBL
MLIEAMAKCLMVVLFFARCAFASDVNAPQTGSSLSENYLALLWHHRLYLYAAAALVVGLW
VSLKVALSRKSGEKDAVSGAIKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKALGF
PAEVIDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYGR
TYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQ
ADFQAWKGKFLSRLQALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEAELVESSS
DEDESDLTGEKRSVVDLEDLGNLMKNAKKAKGKNGPQLDGEVVKFSKLNGVKKIDDDDGE
RREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETT
PSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQDMIRQFRGVPGVKPERY
EEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLEPVTQLYV
SVDASTKESLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYAEL
IALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAAMLPEYEVACEHEHSN
CLLIAHKKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDYMARTPSWALFGAREQ
GFDPADTRFQRRNKTKDISGC
>A0A8H4IQF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryosphaeria dothidea|TrEMBL
MAPSDPLQAISDGKYLLSLWHSSRVPVLLTACAVIALARLLQRLRQPREKLSASPIPGSP
TSKVDKIAAPWANTEKIPAITEKPTMPLDDDHVEEITIAEQPLVRPKTGPKKVTGTKVSR
QAAKRATSFDAARDNVQPLIFFSSLGGTTEAAANKLAEELNQWIYALDTDSIPRPLNPQV
LDLSEVDYDDYFISAPKGDKHTKYFYFVLMPTYNIDTTIDNFLEQLQETHHDFRIDTAPL
SGILGYSVFGFGDREGWPTEEEGFCSQGKEVDKWLAKLTGRKRAYPLGIGDVQSDAQERL
KEWRLGVQEILLDVCAGKGLGEGVPGSGNALESDEEDIDEDEDEVDSETPQSNKPRKTKT
KSNLDDVEDLGKMVKNESDPEEPMEVDFTTYKKSVKAVTPSAPKEMVPTSSPTYSALTKQ
GYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEKIFDGVKEGHYKKIKMMRGVPGVRAERFAEAMCIRHCALSLVGE
PIFYPHINEFTALLHKEHISSFLVCNAQHPAQLASLKPVTQLYVSIDASNKESLRKVDRP
LNRDFWERFCACLDILRERRFEQRTVFRLTLVKGFNMADEIAGYADLVARGLPCFVEIKG
VTYCGTATSAAAGLTMQNVPFYAEVQEFVEALNKELNNRGLEYGIAAEHAHSCCALLAST
RFRKRVDGEWKWCTLIDYDRFFELLESGEEFKPEDYMGEPTPEWALWGNGGFNPEDERVY
RKGKNKEKASDASKEVVEI
>A0A835R9E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vanilla planifolia|TrEMBL
MTFPSTTGFQARLALVALLSLSAFCIWKSHSLRRRRRRLSFPPIPNHERPAKVFFLSQTG
TSESLAERLAARLSAHGVAADLVDPRHYEPEDLPKETLVFFVVSTWEDGKPPPNAAFLAR
WLEESAADFRVGALLLSLCRFAVFGVGSRAYGSTFNAAARSLARWMKALGAVEMMPLWEG
NIDEGEVGKEFGRWSDCVVSLMKGERSLTNGAMGEEIDELEEDEQCDEDEGVGQAAEEDI
IDLEDIAGKAPSKNSKGEPMKENGRIKEMVTPIVRKNLEKQGYKIIGSHSGVKICRWTKS
QLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKDWRWKMDDPLVIV
EAAIDQHTQMIKQMKGVPGVKEEILLEGLSPRHCALSLVGEPIMYPEINSLVEELHGRHI
STFLVTNAQFPDRIKMLKPVTQLYVSVDAATKESLKAVDRPLFGDFWERFIDSLRALRDK
RQRTVYRLTLVKGWNEEDVDAYANLLSLGEPDLIEIKGVTYCGSTATSKLTMENVPWHSD
VKAFSEALAIRSNGAYEVACEHAHSCCVLLAKVNKFKINGHWHTWIDYDRFHELVASGKP
FGTIDYMAPTPSWAVYGAEEGGFDPRQSRFRKERRHGDAAMKDKLATSNLG
>A0A1E3NXV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Wickerhamomyces anomalus (strain ATCC 58044 / CBS 1984 / NCYC 433 / NRRL Y-366-8)|TrEMBL
AVDFTTAFAKKPTTNTATARTINAPKVKRVPKLIKSKGLQSKQKAPPTSMTQANTSLLDS
NIIIFYTSLTGSSERSAKNLYNALSMVDQLKNKPQLLNLDDLTDLDDYFTNTPKLDNLIY
CLVLPSYDVDSPIDYFLQTLEDTYQDFRVDKYPLKKLLGFTVLGLGDLESWPEKFCYQAK
RTDYWLGKLGARRIFPVGEICIKTGGDLKINEWIEMFVDALKDDDPILYEYKDSDAEDDS
DNEGSEEGSSSGESEDTLVDVEDMGKIMKSSNEKSNTNEIKAMVAKNSPTYNSLTKQGYT
IVGSHSGVKICRWTKSALRGRGSCYKFAFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNP
VGTNWRWQVDQPDVILNGALQGHYSKIKQMRGVPGVVAERFAEAFRVRHCALSLVGEPIF
YPYINDFVGMLHEKEISSFLVCNAQHPDQLEALSKVTQLYVSIDAPTKSELKKVDRPLFK
DYWERLIRCLDILRTSQSHQRTVFRLTLVKGFNMEEVSGYADLVERARPALIEIKGATFC
GSSSGNGNPLTMQNIPFYEECQNFVRNLNEELNNRGLGYGIAAEHAHSCCILIGSNQFKV
DGEWYTHIDYAKFFELLKSGKPFDKLEYIAKTPEWALWGSEGAGFNPEDTRVRKKGK
>A0A662QVP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MIPKKVREILEKQHYAIVGEHSAVQICKWTKSSLNGKDGCWKEKFYGIKSHRCCQFSPAV
MWCENQCLHCWRPIEMNLGMQLKKIDNPKEILDGIIKARKKLLLGFKGNKNTSEKKFEEA
MKPTLFTLSLSGEPTLYPQLDEMIKEIKKRKAISFLVTNGQNPEVIKRLMKNNALPTQLT
ISVNTPNKRLFEIWHRSKKQDSWKRFNESLEIIKSLKGKTRRVIRLTLVKQSNEKGKYEN
LSNMKDEYIEQYAKLIEKAEPDFIHVKGFKSLGYSRKRFSYSKQPFHEDVKKFAEKLMKK
LKKSGYKILAEERRSCVVLLGKDKSKMKICQKEI
>A0A832YRV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus okinawensis|TrEMBL
MIPESIYKILRKQHYQINDHSAVKLCGWVRKCFLENKSCYKSKFYGINTHRCIQCTPSVI
WCQQNCIFCWRVLPTDLKEENQGARKNPQWKDPEEVVEQILKMHRTVIMGYKGILDRIGE
EKFNEALNPKHVALSLSGEPTIYPYLKELIELFHKRGLTTFVVSNGILTEVIEEIEPTQL
YVSLNAHDLGSYKRICGGKESNWDRILETLDILQDKKRTCLRTTVIRNLNDDILKFLELY
ERANTNFIEIKSYMNVGYSRKRLNLDDMLKHEEILDIAKTVEENSIFKLEDDSFDSRVVL
LTNKNRKIDPKLKF
>A0A7J2IZQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MLPEKVKSLLKKQHYAIVGNHSAVQICRWTKKSLLDEDFCYKQKFYGIQSHRCCQMSPAV
MWCQHRCIFCWRPIELTLGDKIEGKVDDPKSIVDGCIEAQRKLLVGFGGNKKCNKKKLRE
AFYPKHFAISLSGEPTIYPYISELIAELKRRKITSFLVTNGMLPQVLERIEMPTQLYVSL
DAPNEKLYKKIDRPVTGSWKKLQETLELLQDLKKKTRTVIRITAIKGLNMKNEKEYARLI
EKANPLFVEVKAYMAVGFSRKRLGLKFMPSHEEVKEFSKKISEHSSYKLVDEKENSRVVL
LMEEDTKERKIKFD
>A0A674PNX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
MLASQVKKASSWCLSPLRNHYYFMAIWHNRLYLYSTAALIFGIWFSLKMAIKKVHSNANS
LAYKPVKKNDKDSMVHVSGVKIFYGSQTGTAKGFAKELSDEIKALGIPAVVLDMKDYDPD
DELAVECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGL
GNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRAEGDCNVVKSRNGSVQADFLAWKVKLLKR
LQALARGEKKICSGNCKTEGKCKNKRKVKGEENAALQNNSSESSSDEEESGLQEEKQSGT
MLDMEDLGNIMNLVNKTKSNENGRGKGQTVKLSKLNGLKKTEEEEDVREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWRWKMDPAEKILQDALEKHQNMIRQFRGVPGVKLERYEEGLEVKHCALSLV
GEPIMYPEINTFVRLLHTHNISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKID
RPLFKDYWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGV
TYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGE
WWTWIDYERFQELVGVYEKTGGQRSFSALDYMAKTPNWAVFGAQEQGFDPADTRFQRRNK
TKDISGC
>A0A7L1GGG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Indicator maculatus|TrEMBL
LDVSVDTWNFFYTSLVSLWLQRFYIYFGVAFGLSIWFIIIHFSTKRKKKVTEEKSNGNPT
ALEGTEDKLVNGYANLKAKEVYVAGTKIFYGSQTGTAKRFAKGLAEAVTLLDLPVEVISM
GDYDPEDCLSEETSSRNICVFLVATYTDGQPTESAAWFCKWLEEAASDFRYGKTYLKGLR
YAVFGLGNSVYVDHYNTVGRKVDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWK
TKFLSRLQALCRGEKKPCSGKCKKGKCKSRGKQSKESSDQERGASEPENAEAEELFESSS
EEEADAEEAGGTNSVVDVEDLGNIVSHMKKTKVQFKKFKAENCQYTQGAGFTALVWLSLV
CFNVFGVSVCVFLCCQAMLRGRGGCYKHTFYGIQSHRCMEATPSLACANKCVFCWRHHTN
PVGTEWQWKMDQPEMILQEAIENHQNMIKQFKGVSGVKAARLEEAMTVKHCALSLVGEPI
MYPQINQFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLF
KDFWQRFLDSLKALSEK
>A0A2J8BNW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium dahliae|TrEMBL
MSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQVTGEKPEQLKALPKKL
AADETVAEKAALARDAKAEKPPVVVAEASGAPRAPKTTSGPRRVKGGVVRRRSSDDNVDQ
PPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHKAAPETRCTFEAPELLDLAEVDFDDY
FVTPPPAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSVFGF
GDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIIEIL
GQLARTGGLGEGMPGSGAPVESDEEDADEEDDDETLVEDGEAKPEKLKNSKNLEDVEDLG
RIMKDSRPDSVPAKGKGAPIAVDFTTYGKTAAKKAAPAPPTVKEMVPRNSPTYASLTKQG
YTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGEP
IFYPHINEFLAMLHAERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRPL
HRDFWERFMRCLDILRERRLKQRTVYRLTLVKGFNVDDEVDGYAALVERGLPCFIEVKGV
TYCGTSTASNAGLSMSNVPWYWEVCDFVKKLEARLADKGLRYGIAAEHAHSCCILLASDR
FRVDGKWHTTIDYQRFFELLEERGPDGDWRAEDYMGPATPEWATWGNGGFDPRDDRVDRK
GRKIEAK
>A0A5E4LL41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MARRKNSPTESKYHARLSKEGGAIPKELLATLIKQKYHLAGGHSAAKICHWAASSLTGGA
KCYKHQFYGIESHRCIQSTPVLLFCNHACRFCWRIMPEKKLQQLPSKGFIWDEPGKVAEG
LIAAQKEIVSGFGGNPKVEKGLFKEAQQPRQVALSLTGEPTMYPHLERLFREFRSRGMTT
FLVTNGTFPERIEKWKAFPTQLYVSMVAPDEEVYKRHIRPASPLLWKKYLRTLSLLPAIG
RKCRTVLRMTITRGVNDSGLEGYASQIVLAKPHYVEVKSMVYGGGARQPGRGLSLSSMLS
MEEVESIAGRLSQMTGYIVSEKHAPSRIVLLCRGKEAEKNRLITG
>A0A8C2JHI7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKGFAKELAGDVIAQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTES
AEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARI
MTRGEGDCNVVKSRHGSVQADFQAWKAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHK
EEAEDSHSLAEKNNSEEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKTKRMEG
DEEDSQRVKLSKQNGVRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQ
EAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNIS
SFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQ
QRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEV
IYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGG
TKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A8C0YLC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FERPQKMLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAV
CFTVNMLFKKKKMVDAVSPLLDKSVKNQKRSPEAEKVIHVSGVKVFYGSQTGTGKGFAKE
LAGDVSAQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAAWFCKWLE
EASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCN
VVKSRHGSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEPEDSQSH
AEKNNSEEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKVKTKPCRSTVLTY
SLTCPLSFSVCRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEE
GLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRWDLKPLGKGIVC
VDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLI
ALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNC
LLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERG
FDPSDTRFQRKNKTKDISGC
>A0A3M6U0Z8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pocillopora damicornis|TrEMBL
MAVHEACSQMRYFCIAITLLLVSISVHIDAHSPIDPSIVRKPNWQDRLITWWMSVRAPIG
TLILGGLGLTWLIIKITGKEKHRDEYLRWKARQEKENKKVLKSPTDETETTVSKDLKIFF
GTQTGKAQNLAELLQSEAQESGLRAELVDLKNYEPEDNLSEETATCVFIVSTYVDGKPPE
SVQWFYKWLEEAANDFRVQKSLLQGLNYAVFGLGNSLYEDKFNLVGKRVDKWLELLCAKR
VFPFGMGDENVANSKHGGTEEDFKFWRTDFLSFIKGTSGKSKGNVCQCSSGSNSQVDETC
CQSDEGPQENEGQDDEVLYESTSEESAGEGEEESNSGLVDLEDLGPMMGKMKKDKEEKGV
TGMKSSKRVVGSKKKVKTEPKEMITPALEKALTKQGYRLIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWKMDDPDTIVNGAMEN
HRNMIKQFRGVPGVKPERFEEGMKIRHCALSLVGEPIMYPRINELVRILHGHDISSFLVT
NAQFPDAIRNLIPVTQLYVSVDASTKESLKKIDRPLFRDFWPRFLDSLKALSEKGQRTVY
RLTLVKSWNNEEIKNYADLVSIGKPDFIEVKGVTYCGESKASTLTMQNVPWHEEVIGFVQ
KLTDLLPDYEIACEHEHSNCLLICHKKFKKEDEWYTWIDYPTFHRLMQRYEESNGTENFT
ALDYMAKTPEWALMGHEQRGFDPEETRWHRKKKKDISGC
>A0A564PYL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanolliviera sp. GoM_oil|TrEMBL
MSQYEEILKKQGHHLVGQNEHSAVKLCHWLKKSLRDEGECYKSKFYGIASHRCIQMTPYI
GCNQNCIICWRPTGMKTSFDEMDSPEEIVEASIKEQRRILTGYKGSYRTNMSKYEEAVNP
KHAAISLIGEPTLYPHLEDLIKEYEKRGLTTFVVSNGTNPEVIEEINPTQLYISLESFEE
EMYKKMCRPNEKDLWERVLESLEILGKKRCRTVLRITLVRGLNFEAERFIPLIEHASPDY
IEVKAYMHLGYSRRRLERDRMPTHGEIKEFSRVLDDKTDYSILDDAEISRVVLLSKDKGE
NRMIDF
>A0A151EGU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon SG8-52-1|TrEMBL
MNSEFKKILEKQHYGIVGHHSGVKLCHWMRQSLLFKRECYKQTFYGIKSHRCLQMTPSIN
QCNQTCLFCWRYQGFTEKEFYEIDDPKYILDKSIEVQRKLITGFKGDERCDQKKWKEANN
PNMLACSLSGEPTLYPKLGEFFEECHRRDITTFLVTNGTNPKSLENLDPLPKQLYVSIVA
PNEEVYKKICSPLISDGWEKINQTLELLQSLDTRTVIRHTLVKGWNMDKNYIKEYAHLDE
KASPLFIEPKGYVFVGYSRKRMNLSNMPSHNGVYNFGNSLAKHLSYDLTMEKKDSRVVLL
SRNPKMVRFDK
>A0A8C6LPQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
HTHTHTHTHTHTQIYIQMQCRGFAEELSEEIEALGITAEVVDMKNYDPDDRLADECVGRS
VCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKGLRYAVFGLGNSVYVGHYNT
VGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQAWKVNLLSRLQALAKGEKKS
CSGKCKGGSSCKDKNEEVTSQDASAEKLNRQQFLCEDESGLADERTSGSVVDVEDLGNIM
TSAKKAKVRLAENDEGQMVKMNGGKKTEDDGERREMITPALREALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPAENILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCALSLVGEPIMYPEINTFIR
LLHRHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDS
LRALGEKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEVKGVTYCGESAASSLTMA
NVPWHQEVVAFVQQLADMLPRYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELV
VVHEESGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A401HPM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanofervidicoccus abyssi|TrEMBL
MTTYNTPIPEEVYRILRKQRYQIKDHSAVKLCGWVKKSLLENKNCYKSKFYGIETHRCIQ
CTPSVIWCQQSCVFCWRVLPSDIGVSQLSYPEVKWKEPEEVLEDILQMHRKVVMGYKGIL
DRIGKKKFKELLHPKHVAISLSGEPTLYPYLGELINLFHRKGFSTFVVSNGILTEVIQEI
NPTQLYISLDAYDLESYKTICRGKEEYWQSILDTLDILRYKGRTCIRTTLIRDYNTNIEK
FIHLYEMADVHFIELKSYMNVGYSRKRLTLDHMLKHEEILELSRKVEELSHYKVADDSYD
SRVVLLVNEDRKIERFIK
>A0A670KJV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Podarcis muralis|TrEMBL
MDMTMETWDSLYAHLAFLWLNRFYLYSGAVFGISLWLCIQFVSKTKKQNRNQLRKSSLPQ
IATEGLVEEQKGPSTDKVHVTGVKIFFGSQTGTAKRFASILAESVASLNLPAEVINMKDY
DPDDCLGDETSSKNICVFLVATYTDGKPTENAVWFCKWLEEASSDFRVGKTYLKGLRYAV
FGLGNSLYADHYNTVGRSVDKWLWMLGARRVLSCALGDANVVKSKHGSLEADFEAWEAKF
LARLQALCRGEKAACRGECKKGKCRSKRKAGQETSLEQEQREEVAEEELFETTSEEDSGN
EEGEGANQMVDVEDLGRVMGHMKKAQRERELDQEVEKTGRLQRRGEDALREMITPALRDA
LTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCLETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDPPEMILQEAIENHQSLIKQFKGVPGVRNDRFEEGMEPKHCALS
LVGEPIMYPEINRFLKLLHHKNISSFLVTNAQFPEEIRSLEPVTQLYVSVDAGTRDSLKK
IDRPLFKDFWQRFLDSLQALAEKQQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEVK
GVTYCGESSASNLTMANIPWHEEVGHFVQELVDLLPDYEIACEHEHSNCLLIAHKKFKIS
GEWHTWINYDRFQDLFRQYEQSGGAKTFTSADYVAPTPQWAVFGAKERGFDPTDTRFQRK
NKAKDISGC
>A0A7K8AMT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cnemophilus loriae|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYAAVAFGISLWIVIQFTTTRTKRKVSEDLLQELGA
DKLGNGCAPPQAQEAHVAGVKIFYGSQTGTAKRFAKALAEAVTSLDLPVEVINMGDYDPE
DGLAEEASSRNICVFLVATYTEGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNAVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQ
LQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEAGG
TDSVIDVEDLGNVMGHMKKAKVLLLEGVWHALHGVNHPGCHLGSFVCQFFQAKLNCLMIF
ALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALAVKHCALS
LVGEPIMYPHINCFVRLLHQRGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRR
IDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVK
GVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLLAHSKFQVD
GEWRTWIDYGRFQELVREHERSGGSRTFTAAEYAARTPPWALFGARERGFDPLDVRFQRK
NKARDISGC
>A0A2G9NYY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_60_32|TrEMBL
MDFYERYLQSLPRLRKAGYAFVGNRKHSAVKVCLWARRALCGKGSCYKQKFYGIKSHRCL
QMTPAMPSCNQRCLFCWRDTSLFSEAWPLDGADEPSEIIDGAVAAQRLLLIGFKGNASAD
RQKWLEAQEPNQAAISLDGEPTMYPKLAELIREFHRRGFTTFLVTNGTRPEALRHLAAED
ALPTQLYVSLCAPDEETYEKTNLPVGDDNWTKLNETLMLLPSLATRKVLRLTLVKGLNFH
SPERYAKLVKVSGVDYVECKSYMNVGFSTQRLTQAHMPSHDEIRAFAAELAGNAGYEFTD
EQVESRVVLLSRDAEAARNRFITRV
>C3YDE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Branchiostoma floridae|TrEMBL
MLLAGVVLAPETGAADRKDLSSMLQWLWGLVLNMSSAVVLAMVVNLLLLLRLVYTRRKNK
LKEQTVYVNKDVACYKTSSQDILPPHLRIFYGTQTGTAKHFAELLHTAAQDRGLTSGVKD
LAKVTDPEDTFTEEMEAGSVCVFILSTYTDGQPPEGAAWVCRWLEESSTDFRVSKTLLGK
LKYAVFGLGSSEYGDNFNMASRKLEQCLQTLGAQEVLPRGEGDQNVAGSRHGSLEQDFTV
WRDELLGAVISCESQEESTESCQCKGNDSRQGEDEEVQYESSSEDGSLSDDDDDDALVDV
EDLGAVMNKMKQAKRQVEEEAARGGLRKITVKKKGGEPKEMITPALKKALEKQGYRLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTE
WRWKMDDPQAILDGAMKNHYNLIKQFKGVPGVKPERLAEAMEVQHCALSLVGEPIMYPQI
NTFVQLLHSHRISSFLVTNAQFPDAIRNMDPVTQLYVSVDASTKDSLKKIDRPLFRDFWP
RFLDSLKALSEKGQRTVYRLTLVKAWNVDEIENYAQLVEIGKPDFIEVKGVTYCGESKAS
NLSMANIPWHEEVVNFVQQLADQLPAYEIAAEHEHSNCVLLANTKFKKGSEWWTWIDYQK
FHQLIADYTDSGGHKMFSAEDYMAKTPSWAVFGSREQGFDPQETRWYRKNRKDISGC
>A0A6P4DRH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arachis duranensis|TrEMBL
MPSALSSFPARVTLLALFSATTFYFLYKSRRLRHLKTLTLSSNHTTRGKILFVSQTGTSK
NLAQRLHNLLASKGVVFDLVDAQSYEPEDLPKETLVLIVASTWEDGNPPSGARFFATWLA
ESVKDFRVGALLLKGCRFGVFGVGSRAYGERFNAVAKGFVKQIRDLGGSEVVPLGEGDVD
GGELDLDFEKWCEKVVGFLKGKVLENGVNGNLECGVYDSEEESEGESDLEEEEIVDLEDI
AGKVPPRKKTAAAAESNGNGNGKVNGQREMVTPVIRANLEKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPIEI
VNSAIEMHSNMIKQMKGVPGVTLERLNEGLTPRHCALSLVGEPIMYPEINTLVDELHKRR
ISTFLVTNAQFPDKIKSMKPLTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKE
KHQRTVYRLTLVKGWNTEDVDAYYKLFSIGEPDFVEIKGVTYCGSSATSKLTMENVPWHA
DVKAFSEALALKSQGEYEVACEHAHSCCVLLAKTKKFKIDGKWYTWIDYDKFHDLVGXSV
FLAFLHGAEEGGFDPEQSRYRKERRHHKSSRNQSG
>A0A6B9T9Z3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccaceae archaeon DOK|TrEMBL
MDQAYRDQLIKQQYRLYKDHSAVKLCHWMKESMIRGRCCYKQDFYGIQSHRCLQMTPALN
ECSHMCTFCWRVQDKDFEVGEWAEPKEMLDALIEEQRKLVSGFKGDSRCDLRMYEEARNP
NQVAISLAGEPITYPYLSEFLRECHSRGMTTFMVTNGTYPDRLAELDTLPMQLYVTVAAP
NEEIYRQVCRPKIPDGWQRLMRTLEMLPSLETRTVIRHTLVKDVNFGWVDDYAALDRIAD
PDLVEPKGYVFVGSSRMRLSMSCMPSFAEIRDFSRQLGDRIGMEIVKEREDSRVVLLGHP
GEELDVRKIYGLEPEN
>A0A2R6KZ30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_10_66_29|TrEMBL
MSDSESGPRQVDDPDYHSVNHTATQTCGWTKNALRGEGKCYKNIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQTELLSGFGGNDQVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTKPDVLDECDPTQLYVSVDA
PDRGTFDSTVKAVEDDAWERLIDTLDVLAAKDETRTVIRTTLVKGHNMHRPEWYAAMCDR
ADADYVELKAYMHVGHSRGRLDRDSMPDHEEVVAFAEEMREFLPHDELKQVPASRVALLA
RESETWIPKLQKSSDFWARDPLAE
>A0A7C0WVL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
VGEHSAVKLCHWLKKSLMEDRVCYKQKFYGIKSHRCLQMTPSVTSCTHKCLFCWRPTQYT
FSRIENPDPPEFIVEKSIEAQKELLSGYWGVLDRVNKEKLKEALTPNNVAISLAGEPTMY
PFLSDLIDEYKKRNFTTFLVTNGTNPEVLEEISLPWNLYVTIPAPNKEVYKKLCIPQISD
GWERIMETLELFPSLNTRKVTRLTLVKGYNLKNPEEYAKLIEKASPDYVEAKAYMFVGFS
RLRLSIENMPSFSEIMSFAQELETMTNYKIKDSSEDSRVVLLVKE
>A0A0W4ZJB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pneumocystis carinii (strain B80)|TrEMBL
MFLLLFQLWKSYRVFIIICLILIYTLYFLGSYFQQGISLSNKKSSILSGSSKEDDVISSN
EDKNDLNIKISKSVKIRTPKRFIRSLVERPKASNIDRNVRQSFVENNKQTIVDINDIYVS
ILYQTLLGSTEKYAKLLHDIISPHFEKQVLLENIDFIEDFDDYFVSPEDPESRIFIFLIP
SYETDSPVDLLLSTLKDITYDFRVGAIPLRNLKGYAVLGFGDKNEWPGQKFCYQAKDVDQ
YMSKLGARRVVSVGYCDVKGDIINDIQTWADTLLNAIKNGTMPELVPDVSEESENEPFED
NEGSIVDMEDMGMLMKMNKTKPEELKPKEMVSKNSPTYKILVKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLACANKCVFCWRGNTNPVGTSWRWEVDKPE
DILSGIMEGHYNKIKQMKGIPGIRLERLEEAMRIRHCALSLVGEPITYPHINELVKMLHD
RKISTFLVTNAQHPDALENIERVTQLYVSIDASTKDSLKKIDRPLFKDFWERFISCLEIL
SRKQQRTVYRLTLVKGFNTEEIEQYAHLVSIGKPCFIEVKGVTYCGNTHSSSLSMKNVPF
HEEVVGFVKALAKKLSEMDNVPEYDIASEHVHSCCVLIAQKKFFINDKWYTHINYDRFFE
LVESNMPFSEMDYISETPHWAYFNSPCGGFSPDDIRWKRKNAKNVNFKKEETELQNNTEH
>A0A6G4R596|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronolimnobius sp. AArcel1|TrEMBL
MSDSDAGPNQVDSPDYHSENHTAAQTCGWTANALRGEGRCYKNIWYGIESHRCIQMTPVV
KCNERCVFCWRDHRGHAYELDDVEWDDPDAVADASLELQKKLLSGFGGNDEVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELLEAFHERDITTFLVSNGTNPDVLRECNPTQLYVSVDA
PERHTFDQVVKAVDDDAWDRLLETMAVLREKDDTRTVLRTTLVNGENMHHPDWYAGFYDL
ADPDFIELKAYMHVGHSRGRLDRSSMPDHEEVMAFAEAVGEYMPEFSEVKGVPPSRVALL
SKTDDTWVPKLKKDSEFWARDPVTGD
>A0A8C6WN46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neogobius melanostomus|TrEMBL
MFSNVTWFMQTLAIIVLPLSSAASTSEDRESHGPVLSYITSIWHNRLFLYSAAALIFGIW
FSVKVLQKKSVPSATNPLPQPVKSSDSAKDTVAHVSGVKIFFGSQTGTAKGFAKELLDEV
EASGFPCEIIDMKDYDPDDQLADEGTNKTVCVFLLATYTDGQPTENAEWFCKWLEEASTD
FRYGKTYLKGLKYAVFGLGNSVYTGHYNTVGKNVDKWLWMLSAARIMTRGEGDCNVVNSK
HGNIQADFKAWKMKFMNRLKKLAKGDKKSCNGKCKSGGSCKNKTKHEHGHEERSEHVIQT
VNAEEDLFESSSDEEESGLQDEKKGPVVDMEDLGIIMNGVKKAKSKDGEQMVKLSKVNGV
KMAEDEEGRREMITPALRDALSKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIREFKGV
PGVKPERYEEGLAVKHCALSLVGEPIMYPEINVFLRLLHSNRISSFLVTNAQFPREIRNL
VPVTQLYVSVDASTKDTLKKIDRPLFKDFWPRFLDCLKALGEKKQRTVYRLTLVKAWNVE
EMLAYADLIAMGQPDFIEVKGVTYCGDSTASSLTMANVPWHQEVVAFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKFNIDGEWWTWIDYERFQELVQAYEDSGGEQTFSSLDYMAKTPTW
ALFGAEEQGFDPTDTRFQRRNKAKNISGC
>A0A142CVV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus peptonophilus|TrEMBL
MAITFVSTPNMPEEIVELFKKQHYAIVGHHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCVFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGNP
NVPKEKFEEAWNPRHAAISLSGEPMLYPYMGDLVEEFHKRSFTTFIVTNGTLPERLEEMI
KEDKLPTQLYVSLTAPDLDTYNRVNVPMIPDGWERIKEFLKLMSDAQTRTVIRLTLVKGE
NMHNPEGYARLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPKGRGLKGRFIKD
>A0A8C5RM83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Laticauda laticaudata|TrEMBL
MDTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKNRLAELNLSK
ITAAKKEQQDPSFEKVHVARVKVFYGSQTGTAKRFALVLTEAVASINLPAEIIDMQDYDP
DDSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCAQGDSNVVKSQHGSIEADFEAWKANLLM
RLQALAKGEQKACSGRCKKEQCRSKSKVSQEAKEQETSEHVEKEEEDFFETTSEEESDIE
NGRGADQVVDVEDLGKVMDQMKKSQKEHQTNGEVPIGVGTQHGRGEDERREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALS
LVGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIK
GVTYCGESSASNLTMANVPWHEEVTHFVQDLADLLPDYEIASEHEHSNCLLIAHKKFKIE
GKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKERGFDPVDTRFQRK
NKIKDISGC
>A0A6N2KG78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salix viminalis|TrEMBL
MTIMPLTSTPARLTLLALLSATTVYCFYKSRRLKKISLNPNPNPNKPKLFFVSQTGTSKT
LAHRLHSLLASKNLHFDLIDPQSYEPEDLFKEKLVIIIASTWEDGKAPQNAKFFANWLAE
SAGDFRVGSLMLSECKFAVFGVGSRAYGETFNALAKDFSRWLRDLGAKEVVGVGEGDVDA
GELDMVFEEWSGRLARVLKGESVENGEVSGNGVVFIDESDDDEDDDGVESDIVDLEDIAG
KGPSRRSFVEAQSNGKLNGENGKLNGQKEMVTPVIRASLEKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEI
VNSAIDLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHRRR
ISTFLVTNAQFPEKIQMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLTE
KQQRTVYRLTLVKGWNTEDLDAYFNLFSIGQPDFIEIKGVTYCGSSATSKLTMENVPWHS
DVKAFSEALSLKSKGEYEVACEHVHSCCVLLAKTEKFKVDGQWFTWIDYDKFHDLVASGK
PFNSKDYMAATPSWAVYGAEEGGFDPVQSRYRKERHHKTTH
>A0A640W2N7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNEELKEILKKQHYAIVGNHSGVKLCHWMRQSLLFGRECYKQTFYGIESHRCLQMTPTIN
QCTQNCLFCWRYQGFTELEIENPDDPEFILEESIKAQRKLITGFKGDERCDQRKWREAND
PKHVACSLTGEPTLYPRLGEFFETCHKRGMTTFLVTNGTNPEALEKLDPLPTQLYISVVA
PNKDIYKKLTRPLIPDGWERLQRTLELLPSLDTRTVIRHTLVNGWNMDEAYIDEYAKLDE
KASPMFIEPKGFVLVGQSRQRMTLNNMPSHEQVMSFGKKLADKLGYFFANEKEDSRVVLL
SKNKKVERINKQS
>A0A2Y9PEY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Delphinapterus leucas|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKIMT
RLGKKSVFSSSSPAPLLEPWRQQLER
>A0A1A8W4V0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium malariae|TrEMBL
MLGGKSDHSALLKTIFEIYSNEKKAKINVKIIYGSESLNSYKRAKEFLNELIEFFKNIIT
FCKEIKRITCENENITRNETNELEVELLEYFRSYLRERKKVLLRKNEGKGLLIKRKETTD
EGSERNVRNVVNVVNVVNNEQNRMHNDKQLSELNNDLLDAFGRNVKTSSDTVFSNYVDCY
IKTSISTVHIDFIDGNEFDHYSFFDNLEYYDLNILLLFVSTSNYGSFPKNCYKLEEHLKD
LLKDNKIENNLMKNIFYSSIGFGNKQYGTNYFCAPISTCDRLLSTLGANKLYRTLKLCNQ
EDNEEIISEWKCNLFKMLSLSIFFYCFNYATVGRLAQLSIDKTYMALKYYFSFFCSSKQK
PALEGVQDDKLKRKKKKKKKGKRMEVNMEEREANELEVGVDRGEHMLTQTLAQTQRNKLH
NKTEQCSCSFDSGNESRSGKSKSIICCDEKRMNSEGSLGNEVHNGNASLCNSGSSIGIGC
SSDANNSGHAANKRKGIRQQDECDSNNCEQSTRIISSESRSNGEGEEYSYSSSTDVGTSN
KTAMTNCSSGDEMEDLVSGEPKDMLSINQRNKLTKEGYKIIGSHSAVKLCRWTKSHIRGR
GGCYKHTFYGIISYQCMEATPSLACANKCVFCWRHHKNPVGTKWKWNKDNAESIVEQSVK
KHQGMIKELKGVQSVISERFTNGMNIRHCALSLVGEPIMYPDINKLIDELHKRKISTFLV
TNAQFPEELKKLHKVTQLYISIDAPNKEALRNIDRPLFKDYWERYITCIKILKTRKERSV
FRFTLVKEYNMMGEEILGYSKLIELGSPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQ
FAFHLINSKQVLSDIYEITCEHKHSCSILIAKRVFKINNKWCTWINYEKFHLLVKEKKDF
TAIDYCLETPSWALIGAPERGFNPADQRVYTKGKNKVKNVNVNIPIENDASKGGAP
>A0A8J8PRQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. A20-N-F8|TrEMBL
MLAMQSNIRIDTLSEIYKELKKEKYHIVGTHSAYKKCHWTHESLVTNRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDDTKMPAYDDPEYIVERSIEEHKRAVSG
YFGREGVKLEKVKDAMKPAHVAISLTGEPTLYEKLGELIREYHKRGLTTFLVTSGIRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLLMKTLEILPSFSSPTVIRLTMIK
GYNMSDEDAKEFAKLFQIAMPTYIEVKAYMHVGPSTYRLSKDAMPRHNEIREFAKLLSNY
TGYKILSEHVPSRIVLLSKLDEPIKIGNAWNERWDWRTVDIEDDINGEYKEAELGCTEGS
T
>F0VZB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Albugo laibachii Nc14|TrEMBL
MMSTYSSAWILAVPVAVILLTAVSLQLKDSWYPTIDLICNKAARKSTQKHKTANKKKPKK
SKTSRSSPQMTLSNAPKAIPVRILYGTQTGTSKSMALDLEKRLFACNVSGFHFQPQVINI
KDYDQDHLEHETVVVYILSTWTGGLAPKDAETFCCWLKDMALDFRVSKTWLSHISHAVFG
LGSAEYDEHYCTAAKELSTHLQLLGSSNLVEMGFGDDNVDQMQQFEQWSDQLILKLCSQS
TLSPASDEGEAINGGVDGDQTKSWLSQNHHRRQKRNEKQQEALKLNPQEMAWTEEDLMND
RLLTDDTLEINRDVSPTKQPSKAEDDILDVEDIGSSMRESQMANESQEMVTPMQRKALAK
EGYKIIGSHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRH
HKNPVGRVWRWKTDEPEDLIVGSIERHQNMIKELRGLPGLHLDRWKEAFTVRHCALSLVG
EPIMYPHINAFCRKLHERRISTFLVTNAQFPEKIAALEPITQLYVSVDAATKDALQAVDR
PLFKDFWERFLACLKELRRKGQRTVYRLTLVKSYNMQDIEKYAELIEIGQPDFIEVKAVT
YCGKSDGSDLTMKHVPWHEEVVDFCSALVEKTNGIYGLAAQHAHSNCVLLAKKTFYIDEQ
WHTWIDYEKFHDLMDRYYTDGTLFSSSEYISLTPSWATFDAPEKGFDPCETRFYRTKNGK
IAETSYQSTESGCG
>A0A832VUG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis sp|TrEMBL
MSCSGEFVERDDIIQIKSSIQQQLKKAKYGVADHSTVELCHWTKKSFKGEESCYKHKFYG
ISTHQCMEFSPAGMYCENRCVYCWRPMEFYDSLEMNQENVAEPEDIVVKLMAEREKLIMG
HYGDPKSIHKKLDESLLPAHYAISLSGEPTMYPKLPQLIRYLKTLPATKSIFLVTNGQEP
QMLRRLQSEDALPTQIYLSTNAADRDSFMTINKPRYSDSWERWNESLELLQKLDTRTVLR
MTMIRNHNDSESMIPAFAEMINRANVHFIEIKSYMHIGRSTNRLNRSDMLEFEEIGQFAG
QLAKKSQMYSIIDDSPISRIVLLQNQQRQISPFISAYSHTS
>A0A0M9G2G6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptomonas pyrrhocoris|TrEMBL
MSFLFQLFVSLGLPLIAFLLYDRLAARMGPAEGVKATTTTTTTITTTTTTVPEPNAASKT
HGADAAAFDQQVQAELAKLQDHKKTSTDPMKASSAPSAAAEVSKAAKDKKVPAAILIAYA
SQSQNSLALAHKLFSQLSAHLHTSSQSNSDDADPTAVLPEVRVLEMREEQEEDDNGSSGG
APRDDAASRVKSSNVCRVDTLLDPNHYALTIFITSTYTDGLAPPRSQAFEAMLKDAFEDH
RIPRNTLSQKRFAVFGLGDVAYGEERFNTFAKHLHEWCRGLGAPAFVVPPVYATDNKTQT
LFRVFSTALLKWVNRATFHADGTVTVRKKTDAAASSIAGGGIAARGRRSKKAAGATDGGC
ACRAANIASGGGGGDGGEEGGDGSVNGCCQGSRGSGAGQVEVKCEVEEGEEGSADEDASS
SVGEQESDDMDDVEDLVWDGTDDADFDATQDPNELPELLYPKLRQNLEKQGYRLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYDINSSQCMEMTPSLACANKCVFCWRHHTNPISRHFRW
KQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGF
CDLLHAHHISSFMVTNAQFPEQLRDLKPVVQLYLSIDAPTPDELKRIDRPLFEDYWDRCL
SCVKELARKPQRTVFRLTLVNLYNTDNVKAYADLVAMGQPDFIEVKGVTYCGTSTSSTLT
MKDNVPRHDEVIGFCKALCEEMARRNPHYTTPQMHAAPPKQEKQEQEDFVMREDDVDDVI
VIPPEERDRPYHIACEHEHSCCVLIALDKFFFDHHWHTWINYERFYELIESGRRDFTSLD
YAAVTPTWATYKSKEKGFDPEQTRVAGKKARPTAAAAV
>A0A2U4A9E5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tursiops truncatus|TrEMBL
MWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDLMTNGYI
SLQKKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLGLPVALINLKEYDPDDHLVEEVT
SKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGNSAYVSH
FNKVGKDVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQALCKGE
RKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGTEDHQSL
KSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCALSLVGEP
IMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPL
FKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVKGVTYC
GESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIGREWWT
WIDYSRFQELVQEYEDTGGSRTFSAKDYMARTPHWALFGASERGFDPKDTRYQRKNKSKD
ISGC
>L1JNZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Guillardia theta (strain CCMP2712)|TrEMBL
MIICYGSQTGNAENFAKDLYEDASEKGFKVGIISLASPDFLEKARHALDSSPVFVFITST
WTDGTPPPSCSSFFSWLQQDSCKLELDFNNVKFTVFGLGNSEYAANFCKAARDLDDRLVA
LGGKRVCARGEEDDYSPSIFGSWKDSLWVSQGARLMGNSVQFIQEDSDEESTSSAQEEDD
LDDMLQGEEGGTCGSKADLEDLEDLGKIASRGKEEKEGVVTLRGKPKKMLNPSLEASLTK
QGYKLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIASYQCMEATPSLACANKCVFCWRH
HKNPVGTSWRWETDDPQFLVDGFVSKHRAMIKEMRGLPGVIPERLEEADTVRHCALSLVG
EPIIYPHINKFINLLHEQSISTFLVSNAQFPSQMENLVPCTQLYVSIDASNAEELKAVDR
PLFSDFWERFLECIDILDRKGQRTVFRLTLVKSFNMSEVEGYANLIRRGRPDFVEIKGVT
FTGGKKPQLGMSNVPWHAEVVSFASQICKMVDDEYEIASEHAHSCAILLANKKFKRGSDW
YTWIDYPKFFELVRSGQPFTSLDYMTKTPEWAVYGRGIPGDGGFDPAEIHYRKGDSRTST
PMSSRPDTPSSMR
>A0A819C966|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood1|TrEMBL
MTVDLYIFAAGTALTGLVFYYLAGAEWSLWHLFTIPLYTFIFIVFLSLSILKRFKTQLST
KIISQDKNGITIVFGSVKGNSRTFAQLTYDKLLNELNRQVILQDLNDITDPEEFLQIQVK
NQRILLIFISTYEDGIPPPSAKWFLRYLQEAATDFRVSKNELEKLTYTIFGCGNSLYNDN
FNKVAKELDRCLLELSAKQFIPSEYADENTVKSIYGGLEGHYSKWLSQLISNLQSSKADK
CDCSNDKSINCCQSLTNNNHSNENIEQLRIESDDDDEDGGGCKNGNDDIMDLEDMGDYME
THSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENHYKMINTF
KGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHSKKISSFLVTNAQFPNEM
KTLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLDSLRALKDKGQRTVYRLTLVKGY
NTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASHLTMANVPWHEEVVTFVKLLCDRLPQ
YDVACEHEHSNCLLLANKKFCIDGKWYTWIDYERFHELVTRHKVTSGAETFTSVDYMAIT
PDWAVVGSNERGFDPNDTRWYRKATAKKNLSGC
>A0A2P2KUF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophora mucronata|TrEMBL
MKVDSETGSEARLPLLYYSYIIIKPSSNENPTKETERRKSMSLYSTPARLTLLALLSATT
FYCFYKSRRLKLSLNSNAKANRKPSAKGKLFFVSQTGTSKTLARRLQALLASHGISFDLV
DPKDYEPEDLSRETLIIILASTWEDGKPPPNAKFLSDWLAESADDFRVGALLLSKCKFAV
FGVGSRAYGATFNAVAKEFSRWLRELGATEILGVGEGDVDGGELDGVFEEWGGKLVRVLE
GGSLENGGVLGNGVVVGGESDSESIVDGFESDDEDGSNGVLDSGIVDVEDIAGKGPSRRS
ASVAETNGKVNGQREMVTPVIRANLEKQGYKIIGSHGGVKICRWTKSQLRGRGGCYKHSF
YGIESHRCMEATPSLACANKCVFCWRHHTNPVGKNWQWKMDDPLEIVNSALDQHTKMIKQ
MKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINVLVNELHQRRISTFLVTNAQFPEK
IRMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFTESLQALKERQQRTVYRLTLVKG
WNTEDVDAYFNLFSIGKPDFVEIKGVTYCGSSASSKLTMENVPWHSDVKAFSEALALKSN
GEYEVACEHIHSCCVLLAKTEKFKRNGQWFTWIDYEKFHDLVASGKPFNSTDYMAATPSW
AVYGAEEGGFDPNQSRYRKERRHKSSH
>A0A7J2TA85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MTLVGGTTVNPVIQALSVLKKQKYHIIGSHSAVKKCYWVHKALVEKMFCYKAKFYGIESH
RCIQFSPSVLWCWNYCLHCWRYRSRDQWNDIWFHFPENIDDPRFLVEMAVKEHRRTVSGY
KKYPNVDKKMYEEALNPKHVAISLTGEPTLYPCLGELIKEFHNKGLTTFLVTRGIRPEVL
ANLDEEPTQLYVSLEAYDSGSYTKFNNPISGSLWERTLETLEILPSFSAPTVVRITLVKS
FNMNEEAIDAWARLLKVAQPTFIEVKAYMHIGASITRLSRSDMPSHTEVRRIAEELAKRL
GYNIVSESVPSRVTLLSTLDRPVIRYGNPPVTWHDVDVGGEDSGEYGSTNEAP
>A0A7J3MY03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MTYNAVAVHQRDDQVLNILHKQKYHIVGSHSAVKKCYWIHKTLTEKMFCYKAKFYGIESH
RCIQFSPAVLWCWNYCLHCWRYRPGSDHGFRTIEAVDDPRFIAEMVVKEHKRTVSGYKKY
PNVDRKMYEESLNPKHVAISLTGEATLYPRLGELIEEFHRMNLTTFLVTRGIRPEILANL
GTEPTQLYVSLEAFDEDNYRYFNNPVYPNLWKRTLETLEVLPSFSSPTVVRLTLIRSFNM
NLRAVSEWVKLLKIAEPTFIEIKAYMHIGTSILRLSRDDMPSHKEVREIAIEIANRLGYN
IVSESVPSRVVLLSRLDKPVIRYGNPPVSWYDKDLLDEYSGEYGVLDDFI
>A0A843EV59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MSFNTSQQEKLEKSGYRFVGTHGHAAVKTCHWTRQSIVDKGVCYKEKFYGIESHRCLQMS
PAVPNCQQECEFCWRDLTYTQTEWEDDEYDDPKTIVDGAIEAQNNLLCGYYGNDKANSKK
LEEIKKPTNAAISLAGEPTLYPKIDELIGEFNKRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPTSKIYDAVCRPRISNAWDNLNESLETLSSFNSRTCIRNTCVKGRNMVNPEKYA
QLIDKANPDFVEVKAYMCVGSSRQRLTLDNMPTFDEVKDFAQKIGDNCGREISNESEVSR
VVLLE
>F7PNH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorhabdus tiamatea SARL4B|TrEMBL
MTEDTRQVTDPDYHSEGHTAAQTCGWTDNALQGEGRCYKYAFYGIRSHRCIQMTPVVRCN
ERCVFCWRDHAGHTYELDDVAWDDPEAVVDASISLQRKLLSGYGGNDAVPRERFEEAMEP
RHVAISLDGEPTLYPHLPELIEAFHDREITTFLVSNGTDPEMLAKCDPTQLYVSVDAADR
RTFDDVVKAVDDGAWERLIDTLDVLAEKDETRTVLRTTLIDGDNMARPAWYAAMADRADV
DFYELKAYMHVGHSRGRLDRSAMPDHDDVLSFTEAVGEFLPDHDVIKESADSRVAMLARE
EDTWVEKLAPESDFWEQGTTAGWTPKGGR
>A0A2E8HE78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPKIAARLAKQRYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVKAHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQAAFNKLEETLGILPSLDTRTVCRHTLIKGESLGYHDEYARLDNLA
DPDFIEAKGYVFVGNSRNNLSIENMPSHEDVMEFSRTLAPLVGREVLSDRKESRVSLIGK
EMIPVKLPEKTRDLPQDLGIAKPQNFSLPVTLN
>A0A0P0N4F2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrodictium delaneyi|TrEMBL
MTQADFRPRTVRNKRWKYRIDDFPEPYRSLYRILERQGYIIVGRHSVVKKCHWTHAALVE
NRFCYKCRFYGIESHRDIQMSPAALWCWNACLHCWRLRPTDTIRWDDTKLPWIDDPDLIA
EGSIEAHRESLMGYWGHPKADERMKRMLEEAMNPVHVAISLTGEPTLYPRLGELIHEYHK
RGLTTFLVTRGVRPDVLANLEEEPTQLYISIEAWDKKSYNEFDKPLVPRAWELTLKTLEM
LPSFSSITVIRFTLVRSFNIHDTALKAWAKLVEIAQPTYIEFKSYMHVGAARHRLSNKDM
LRHIEVLAFAKKFAELTGYKILSQQIESRVVLLSRIDKPIRVGEGCKGEIEKEKSRLEEM
LDKLRVDNHLDEVEYRMVLDQKI
>A0A089ZHP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium formicicum|TrEMBL
MPLSDQNIKTLEKKGYRFVGSHNHSAAKVCHWTKKSIMDDGVCYKEKFYGIKSHRCLQMS
PSIPFCHHKCLFCWRDVDVTSTSWTEDYDDPGQIIDECIEAQRKLLVGFFGNPNANQEKV
LEAQDPTNAAISLAGEPLLYPSINQLLEEYARRNFTTFLVSNGLSPEKLGNLDPEPTQLY
LSLDAPNREVYQKICEPQIPDGWERLNHSLELLSSFNCRTVIRMTCVAGHNMTHPEEYAR
IIESTNPDFVEIKAYMYVGSSRERLKFENMPRSRDILSFAQNIASLCGREIVDQSLESRV
VLLA
>A0A452UJ84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ursus maritimus|TrEMBL
MDPSLDTWDFSSPLMSLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSQEKSVP
KATQDLMTNGYISLQEKEVFVSGVKIFYGSQTGTAKGFAASLAEAAASLGLPVAVVNLKE
YDPDDHLVEEATSKNVCAFVVATYTDGRPTESAEWFCQWLEEASSDFRFGKTYLKGVRYA
VFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTK
FLAQLQALQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNPNSVVDVEDLG
KIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQLPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLKALAAKGVTYCGESSASSLTMANVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLI
AHKRFKIDSEWWTWIDYNRFQELMQEYEDSGGSATFSAKDYMAKTPHWALFGACERGFDP
KDTRYQRKNKSKDISGC
>A0A814ELE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFKSSPKS
PSSKKIIPLEKHGVTIVFGSVKGNSRTFAQSTYDKLSKDLNRQVIIQDFNDVTDPEEFLQ
TQAKNQRTLLVFIPTYEDATPPPSAKWFLLHLQEAATDFRVSKGELEKLTYAIFGCGNSL
YFENFNKVAKEVDRCLSELGAKRLLPTELADENTAKSIYGGQEGHYSKWSSKLKSTLETP
KTEKCDCSNDTSTTTCCKTVTNGDHSIKNDDNNNDDDEEEPRIESDDDDEAGGCKDGNDD
IIDLEDMGEYMENSSPTKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAKTVTQG
AIDNHYKMINTFKGVPGVLPARLAEGMKIRHCALSLVGEPIMYPHINELIEILHSKQISS
FLVTNAQFPDEIKTLQPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKGQ
RTVYRLTLVKGFNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASSLTMANVPWHEEVV
TFVQALCERLPQYEVACEHEHSNCLLLANTKFRVDGKWHTWIDYDRFQELVARHKATSGA
ETFTSLEYMAATPDWAVVGANERGFDPSDTRWHRKSTAKKDLSGC
>A0A7K4DQ86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGETVEEDDHLIQIKPAISEQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDSEQVAEPEDILVKLMSERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLRINKPKYDDSWKRWNRTLDMLKSIDTRTVL
RITLIRDFNTQKEMIPAFAEMFRKSSPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVKSFS
NEIVKQSKIFSLMDESLVSRICVLQNNERLIDRWIPAYVNTI
>A0A163EVV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Didymella rabiei|TrEMBL
MAIQTSLEQLFAELLGIWHTHRVSLLVVAVSLALIVRLTSQRRNGREKVSVSPAPTSPVE
EKKTVVLRPEWLPENTTIVTSSLNVDNHAEDDTKVVASAAKVKKGPKTVKGQKRPKKVAK
PVIDYNHTRDKIQPLIFFQSVTGTTERRAAQVAELLTSWTAGCEQSASFLQPQLLDLSDL
DYDDYFINAPKAEANTKFFYLILAPTYNIDTLLDAFIENLSETHHDFRIDTASLGGLVGF
SVFGFGDKEGWPSEEEGFCTQAKEVDKWMARLTGRKRAYPLGMGDVKSDAEERLTEWRLG
VQEALVEIAEGRGLGEGVLGSGDAVESDEEEVEDEEGSEEAARVDDVEDLGGMANDTVAP
IPVDFTNYKSKAKVNAPSGPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDVIFDGIT
AAHYKKIKMLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLGLMHKKRISTFM
VCNAQHPAQLASLVPVTQLYVSIDASNKESLRKVDRPLHRDFWERFCACLDILRARRFEQ
RTVFRLTLVKGFNMEEEVKGYADLVERALPCFVEVKGVTYCGTSAAGSAGLTMQNVPFYE
EVAEFVTLLEKELNSRGLVYGIGAEHAHSCCILLADSHRFQRNGRWATRIDFERFFDLYE
GKVQGTRMQDGEVVGWRPEDYLGPDTPEWALWGNKGFDPRDQRVYRKGKGPKTEDEAKAS
PLKVVSRRAAFEF
>A0A8B9JZZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
MSGLVDGAWSYTEGWLWMVWQSRLYVYTAAAVLLGLWLTVNMTLKKKKTVLTSSPPLSKS
EKKKEKLPEKEKVIHVEGVRIFYGSQTGTAKGFARELADDARATGFHSEVFDMKDYDPDD
RLSDECTSKMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLG
NSEYVGHYNTVGKNVDKWLWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRL
QALARGEKKACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESAGEEEKAH
GSVIDMEDLGNVMNHMKKAKKQSEEESQRGKLSKLNGVMKTEGEEEAREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLV
GEPIMYPEINAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGV
TYCGESSASSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGE
WWTWIDYERFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNK
TKDISGC
>A0A0L0W0S8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia striiformis f. sp. tritici PST-78|TrEMBL
MFGLVESITNLIKPAAKPLKTQILYSSLSSTTKKLAEQLSTLLLTESEHLNSSIDTLDNL
DLDSLINQTPIDTVNQLIIFLLPSYNVESPVDSVLSQFRDALYDFRLDKNSLAGLSFFVI
GIGHSDYQNEFCKQAVELDSIIANLGARRIINLKKIDVSVDPEKDLSDYFQTVIRTTLSP
SLSSFAQLPPLSSSSEDDDNDEDENSDDEFKDYTSSKPLTKAEKARQKSSTKKKKSSAGT
TKEGTMDIEDLGTGIPQIEDLDIKDQDDEIIKKDMISPMTRKSLTKQGYAIVGSHSAVKT
CRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLACANKCTFCWRAHTNPVGTSWRWKTD
SAEYIIEESLKEHDRLIKQLSGMPGVRADRFTEARTPRHAALSLVGEPVMFPHIKKYISL
LTEKRISTFLVTNAQFPESLKDLPPVTQLYLSIDAGTKESLKSIDRPLHRDFWERFLESI
DIVHQKKNRTVFRLTIVKGENENQIKEYADLVRRGQPDFIEVKGVTYCGYPGSSNLTIKN
SPWHEEVKKFVEDLCEEINDPRYRTESSSGESKDGSTLEYGLAAEHAHSCCVLAAHSKYY
FDDKWHTWIDYDKFFELVEAGSTDFDGLDYCDITPDFALFNSAEAGFSPEDQRWFRKKTL
AAQKEKLDQLNQDHQKEDDQNILPPPIGPSQ
>A0A2P9D2E9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium sp. gorilla clade G3|TrEMBL
MGIVEHGFLLKNILGTQCNEKKVKINISVIYGSGDGNSYNRAKDFLNELIEYFNNVHLFF
NDMNEIINKNIYINDINGNLSYGDILPKKDYNEKKIEINNNYKNDNGVNHDNTDNNVIYK
NNCMNTSLNIKDINSLENEIIEYFKLRFDKYQGNNKKRKEKISRSGYENIIPLYYNKNIN
YLEPYEENIKMFNNKFKNYVDCIIDNNKIGIIYFNLIDGNNHDYYSFFDSTENYNLNVLF
FFISTSSHGSFPNNSFKIDEIFTDMLNDFRIDKNYLKDIFFSCIGFGNKEYGDKYFCTPI
KKCEKYIHLLGAQKLYKTLKLCDTQDNEETILLWKCNIFKTFSLSLFFYSFNYMKRWYMN
KRIYDTLSYYCYFFSNYTNSNLNQNQHIKYMYDQKTEVEKKKKKKKSNLSIYPMDELEGC
HCNKEYQENNLPIDYSNINYNNNKCCNNEIYNTQNDIYTNVKNVHQISLSNIDNDDEDLI
NKHKTKMDKTNTMMNEKREEVYVNSNVFLLNGDNQRIEGCTNCNCESINDYNDKSNTNSI
NKINNTNNRLNTNNIITCDNSISESESSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQR
NKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCV
FCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIILERFEKAMHIKHCA
LSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPVELENLNTVTQLYLSIDAPNKEAL
KNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDF
IEIKAVTYCGSSQGYQLTMKNIPWHEEVYQFAWNLINKKKSLSDIYEISCEHKHSCSILI
AKKIFKINNKWNTWIDYEKFQQLIKNKEIFNALDYSVETPHWAIYGSQESGFSPCEKRVY
TKGKYKNKNHQS
>A0A671PI04|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MEQHMKCHKKVIIDLCKLYSRAFTGVLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGVCF
TMNMLFKKKKTVDPVSPWLYKSAKKQDLSAETEKVIHVSGVKVFYGSQTGTAKGFAKELA
GDVSAQGIQCDIIDMKEYDPEDRLTEECTSKMICVFLVATYRDGQPTESAEWFSKWLEEA
STDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVV
KSRHGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGSCKNKKKHKKEAEDSHSLAE
KNNSEEELMESSSDAESSSEEEKSHGSVIDVEDLGNVMNHMKKAKVKTKPAPPTLYIARY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTN
PVGTEWRWKMDPAEKIIQEAVENHRNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPI
MYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLF
KDFWQRFLDSLRSLGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFIEVKGVTYCG
ESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDREWWTW
IDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGAQERGFDPSDTRFQRKNKTKDI
SGC
>A0A7J8J0I1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Molossus molossus|TrEMBL
MDPSLDTWDFSPLIPLWINRYYIYLGFALGISLWICFQIVIRKQSFIFKGKNSQERSIPK
ATRDLMTDGYISLHKKEDFVSGVKIFYGSQTGTAKEFATILAEAVTSLHLPVTIINLKEY
DPDDNLVEEVTSKIVCAFLVATYTDGRPTESAEWFCKWLEEASNDFRFGKTYLKGMRYAV
FGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGSIEADFRAWKSKF
ISQLQVLHQGEKKSCDGNCRKGKCESSQHGSEEMEPGSHTKDRSHQRDPEEEEEPFESSS
EEESGTEDHQSLTSVVDVEDLGKIMNLVKKEKREEEQQEEKAGVFRNTVKKEASERRAMI
TPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWEMDQPEVILKEAIENHQNMIKQFKGVPGVKEERFKEGMK
VKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGS
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVHELVDLIPNYEIACEHEHSNCLLIA
HRKFKIGREWWTWIDYNRFQELVQEYEDSGGSKTFSAEDYMAKTPHWALFGASERGFDPK
DTRYQRKNKSKAISGC
>A0A671Q597|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MCVHYCCCSHRSLAYCEHAFQKGDKVCLLLKPLCYLKFFFLLIKKMVDPISPLLYKSVKN
QELSPETEKVLHVSGVKVLYGSQTGTAKVCIHWWSKVWNNKEFLERHFFKMICVFLVATY
TDGQPTESAEWFCKWLEEASMDFRYGKTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWL
WMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWETKFLKRLQALAKGEKKACSGKCKSGS
CKNKKKHKEEAEDSQSHTEKNNSEASQPSSLMSLNTCSHGNSSRSAHPESRLFPCSLCCT
HQNGVRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIR
QFRGVPGVHPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPE
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVK
AWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLL
PDYEIACEHEHSNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMA
KTPSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A671Q571|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
ALNDVWEFTESYLLTVWRNRLCVYTTAAVLIGVWLTVNMLFKKVIKFLSSACVIVIIIYL
SNLKNYMQLCCDVFLAGGISAQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDG
QPTESAEWFCKWLEEASMDFRYGKTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWML
SAARIMTRGEGDCNVVKSRHGSVQADFQAWETKFLKRLQALAKGEKKACSGKCKSGSCKN
KKKHKEEAEDSQSHTEKNNSEEELMESSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKA
KVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPS
LACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIRQFRGVPGVHPERFEE
GLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSV
DASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIA
LGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCL
SLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGF
DPSDTRFQRKNKTKDISGC
>H3DNU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetraodon nigroviridis|TrEMBL
VSAVKILYGSQTGTAKGFAKELSDEVKALGIPAEVIDMKDYDPDDQFAVECTTKSVCVFL
VATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYTGHYNTVGKNV
DKWLWMLSGKRIMTRGEGDCNVVKSRNGSVQADFLAWKIKFLKRIQALAKGEKKICSGNC
KTEGKCKSKRKVKEQENAALQNNSSEQHSEDSAEGELIESSSDEDESGLQDENQSGSVLD
MEDLGNIMNRVNQKKTKSEEDGRGNDQTVKLSRLNGLKKTEQGEDVREMITPSLREALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDPPEKILQDALEKHQNMIRQFRGVPGVKPERFEEGLEVKHCALSLVG
EPIMYPEINTFVRLLHTHNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELITLGQPDFIEVKGVT
YCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEVACEHEHSNCLLLAHTKFKVDGAW
WTWIDYERFQELVRIYEETGGQRSFSALDYMAKTPSWALFGAQEQGFDPADTRFQRRSKP
KDISGC
>A0A075HRC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_79_H09|TrEMBL
MSCSGEFVEKEPELIQIKPNIAQQLKKAKYGVADHSTVELCHWTKKSFKNEGTCYKHKFY
GISTHKCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDEQKVAEPKDIMSKLMEERRKLIV
GHFGDPRQDKQKIEESLTPSHYAISLSGEPTMYPKLPDLIKYLKSLEATKSIFLVTNGQE
PEMIQRLADEDALPTQLYLSTNASDYDSFLKINRPKYDDSWKRWNKTLELLAELDTRTVL
RVTLIKDWNDSEKMISGFTSIFEKSNAHFIEIKSYMHIGRSTNRLEYDNMVDMSDVRKFS
KYIAKNSDRFEIMDESEVSRIVVLQNKKRFTERYLSAYA
>A0A662RAL9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MSHEIQELLKKHGYQRAGRHSAVKTCLWLKRSINNKGQCYKSQFYGITSHRCIQMTPTLQ
CNQRCLHCWRAIDATIPKTPWDPPEVIVDETLRAQQRLTSGYGGSDQANKKLWEESKNPL
HVAISLAGEPTLYPYLSELINIFHKKGMTTFVVSNGTHPEVIREINPTQLYLSLTAPDRE
TYQQTCKPEREEMWEDLLKSLKILSGKKGRTTIRITLIEGLNDTKPEEYAKLIKLAKPDY
IEIKSYMHLGFSRKRLERNKMPTHTKINKFAQKIIEHTEYKWADENEPSRVVLLSKDGKT
DKL
>A0A851JD91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Donacobius atricapilla|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTRTRRKVTEPGAADKLGNG
CAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEIINMGDYDPEDGLAEE
TSSRNICVFLVATYTEGQPPESAAWFCRWLEEAANDFRVGKSFLQGLRYTVFGLGNSAYV
DHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSRHGSIEADFEAWKTKFLTRLQLLCK
GEKKPCSGKCKKEKCKSSGKRSKEGSDHEHGTSEHENTEAEELFETSGEEEAGGTDSVID
VEDLGNIMGHMKKAKVLLLEGEWLGVVHGVSHSGYHLGYFVCQFLQAKLNCLMICALSSG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFQDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYC
GESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRT
WIDYGRFQELAREYEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARD
TSGC
>A0A662Q6X7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MAKLRKAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGIRSHRCLQMTPSLQYCNLMC
IFCWRHHTINRVEAYSGDWDPPEEILDGLIKEQRQLLSGFKGNPRVDRRLFEEAMEPKHM
AISLDGEPTMYPYLGDLIKLARRRGMTTFLVTNGMNPAALKKLVEEDAMPTNLYISVYGH
NEELHRRICRPLIPDSWNRLLESLRVMNEFQGSRKVIRLIMIKDYTMQDPEKYAELIKLA
NPDFVECKGYMHVGESQKRLRKENMPTLDEIRIFAQKLSSELGYEYLAVDYPSRVSLLAN
PSSKYYDEVRRRILKQSGG
>A0A835FQX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Digitaria exilis|TrEMBL
MTVGRGPPGRPSSSALLGCWRRRPPLGFGAKVGIAIALGLSFAIIWTSVSPTLSSQQIST
ERSSFAAEVAAPPTATDNRTSASAGGGHAHRKPRPAPHSHKKRHPAPSGSHPHPHRPNAT
ASPDAADEKADHSDSAPLTDPEPKEKEPEQEQEPDMEMEPEQEAELPMPEESGDKSGKAP
AEGEEEKPPQLELEEEPGEGDGDEDFEEAAKKTAPSKKRKLPPLFNPGAHYHWKHCGAKS
GYHYIPCVDFDGDGSQRHHERSCPRSPVTCLVSLPKDYKQPAPWPERKDKVWYGNVAHPR
LSNYVKGHSWMNHSGEYLMFPPDEWEFKGGARHYVQSIDEMAPDIDWGKNIRIILDIGCK
SAGFGIALLEKDVITLSLGLTNDQTDLAQVALERGVPATVGSLGSRRLPFPSGAFDAIHC
GECNIPWHSNGGKLLLEINRILRPGGYFIISSKSADLESEEGISASMTALCWNAISYNSD
DVSEVGVKIFQRPATNEEYDLRAKKDPPFCKEEQNKANAWYTHIKHCLHKAPVGIEERGS
DWPEEWPKRLESYPEWLGDLQTRVAADHNHWKAVVEKSYLDGLGIDWSNIRNVMDMRAVY
GGFAAALASKKVWVMNVVPVHAADTLPIIYERGLVGVYHDWCEPFSTYPRSYDLVHADHL
FSRLKIRCRQPVAIVVEMDRILRPGGWAIIRDKLEILDPLETILKSLHWEIVMTFRKDKE
GIMSRLSARLTAGAGVSVRATDASAFDPDDLPSVPLLLLVVPTHDGGAPPPSAAFLARWL
EESAADFRAGALLLSGLRFAIFGVGSRAYGETFNAAARSFSRWLRALGAVEVVPLGEGDV
DGGDLDSMFEDWSGKVLRVVKGEELDEGLLGESNGLNELELEGEEDDDDDEEEAVAGEID
MEDIAGKAPARRQNGKVESSLANGGQNGVKEMVTPIIRTSLEKQGYKILGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDEPL
DIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVDELHR
RHISTFLVTNAQFPEKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSL
HEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLTMENVPW
HSDVKEFSEVLAAKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELVTS
GKPFKSQDYMSMTPSWAVYGAEEGGFDPDQSRFRKERRHGTAALQA
>A0A6P6QYS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Carassius auratus|TrEMBL
MLFLALVSCLLYCTVGAEKSDALHDVWDFTESCLLTVWQNRLCVYTTAAVLIGVWFTVNM
LLKKKKMVDPISPRLDKSVKNQKLSPETEKVIHVSGVKVFYGSQTGTAKGFAEELAGDVS
AQGIQCEVIDMKDYDPEDRLAEECTSKMLCVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKSSSCKNKKKHKEEAEDGQSHAEKNSS
EEELMESSSDAESSAEEEKAHGSVIDMEDLGNVMNRMKKAKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRG
VPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYE
IACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQERVQEYEESGGTKSFSAMDYMAKTPS
WAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A1V5TLD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon ADurb.Bin253|TrEMBL
MLDKNIKQLLKKQHYEIAGKNEHSAVQICRWTKKSLRDEGVCYKEKFYGIKSHLCCQMTP
SLYCPNKCVHCWRAIEYTTGEKIPGKIDSPSEIIDSCILSQRKLLQGFKIDKNSKKIQLS
KANQKKYKEAQEPMQFAISLSGEPTTYPYIGELIAELRKRGKTSFLVTNGLYPEKIKELL
EKNQLPTQIYISINSSNENQYVKFHRSIKKDAWKKLNETLDILPKLNGKTRTVFRMNLVK
ELNMFPEQAKEYAQLIKKSQPRFIELKSYMAVGNSRKRLGYERMPTEKDMKNFIDILLKE
LQGTGYKLLGEHSFSRAYVLGKDKKELKIKDSEL
>A0A1I0P9S8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halopiger salifodinae|TrEMBL
MSDSANSGGDGASADAEAGPDGDADRTGGPAQVSSPDYHSENHTAAQTCGWTANAIRGEG
KCYKYIFYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDASIRL
QKKLLSGFGGNDEVPREVFDQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVS
NGTRPEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDSWERLLETMDVLAEKDETRTVL
RTTLVDGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEEVVAFAED
VKEYMPAFAECRGVPASRVALLAKEKDTWVPKLKKGSEFWERDPVVGD
>A0A672UUE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigops habroptila|TrEMBL
MDTWSFFSTCLVSLWLHRLYVYSAVAFGISIWIIIQFSTSKHQKKVAPRADKLVNGCATL
QAKEVYVAGVKIFYGSQTGTAKRFARALAEAVISLNVPVEVISIGDYDPDDCLLEETTSR
NICVFLVATYTDGQPTESAAWFCRWLEEAANDFRFEKTYLKGLRYAVFGLGNSVYVDHYN
TVGRNIDRWLWMLSASRIMTCAEGDCNVAQSKHGTIEADFEAWKAKFLSRLQALCRGEKK
PCSGKCKKGRCKSPGKQSKESSDHEHGASEYENTEAEALFDTSSEAEADAEEAGGTNSVV
DVEDLGNIMRHMKQAKRERELEEGDVGMSLTRENAGRKEEGGKREMITPALREALTKQGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEMILQQAIENHQNMIKQFKGVAGVQAARFEEAMTAKHCALSLVGEPI
MYPEINRFVRLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLF
KDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCG
KSSASNLTMANVPWHEEVVHFVQELANLIPHYEIACEHEHSNCLLIAHKKFKINGEWCTW
INYDRFQELVRAQEQSGGSQTFTGADYAARTPHWALFGSRERGFDPLDVKYQRKNKARDI
SGC
>A0A8B3S0Q3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Argoarchaeum ethanivorans|TrEMBL
MLLYYELFKIHGCRRMLTSSNFESLLKKHGYHMAGSHSAVKTCLWLNKSLRGEGKCYKFQ
FYGIASHRCVQMTPTMQCNQKCLHCWRPTEIDVPETGWDSPELIVEESLKAQQKLISGYG
GADIIDKTLWEEAKNPRHVAISLAGEPTIYPYLDRLIDTFHSKNMTTFVVTNGTYPAMVE
QINPTQLYLSLNAPDEYTYRQTCNPQEEGLWKRICKSLDILREKETRTVLRITLTEGLNI
SSPEGYAALIDRASPDYIEIKAYMHLGFSQKRLERSAMPTHQRIREFSERIMQYTDYKQA
DESQISRIVLLSKNGDVKKIV
>A0A7M3WYQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVSSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTRGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDAVCRPKWNTHAWEKFEETIDLLPSLDTRIVARHTMMKGINMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSIENMPSHDDIMDFSNKIAPLVNREVLSDSRPSRVALV
GREITPIPIPKATMFFPEDLGIAPSVKHLPMAG
>A0A1V4TR44|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon PtaB.Bin215|TrEMBL
MKNDLREILQKQQYRLCGDHAGVKLCHWMKQSLLKGRTCYKQDFYGIRSHRCLQMTPVVN
DCTHNCLFCWRVRGFESTVTKWQDPETVLDTCIEGQRQLVTGFKGDPRCSPAMWEEARDP
RQVAISLAGEPTIYPYLGDFIELCHRRGMTTFLVTNGTFPKVLEQLSELPTQLYVTVAAP
NQDIYKKLCVPRIDDGWERLMETLDLLPSLNTRTVIRHTLVKDWNLGWEKEYAALDRRAD
PTFVEPKGFVFVGDSRRRMSMDNMPSHAEVLEFGRRVAEELGMCMLREKSDSRVAVFGED
GADTKIPGLDQSG
>A0A8H3IKK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Heterodermia speciosa|TrEMBL
MTFQGLVSTWQEYRVPFLLAQLALLGVVLSIRFVQYRNAQKSKTLRAPPVRSPILVSKDK
NWQEGDNDRSPDPAFREIVKKFDQDEGPLQAKVAGSQKRMPKRVTGVKATKNLGIEEAGN
RKILPVIFFSSLTGSSERYARTLTNDIRQSLHRQASNVLEPQIHDLSYIDYDDYFVTPPK
PAEGLQYFYLLLVPTYNIDTVLTTFLDNLKETHHDFRIDTAPLVSLAGYSVFGFGDKEGW
TTEEQGFCSQAIEIDRWMAKLTDRKRAFPIGLGDVKSDVQSQLEAWKRGVESVMIDISIN
GSLGEGVRGSGDSLESDEEDVDTTGAGSAASKPRKPTKRIPNTSTNLGDLEDLGENHGLD
TGSDADRTQISTPIPVDFTISKNTSTAPQPLKEMVPASSPTFTALTKQGYAIIGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQV
DPPDLIFSGAKEAHLKKIKMMRGVPGVRAERFQEAMRIRHCALSLVGEPIFYPHINEFVQ
LLHADKISSFLVCNAQHPEQLESLKVVTQLYVSIDASNRESLRKVDRPLHRDFWERFVKC
LDIIREKRFRMRTVYRLTLVKGFNIEDEAEGYAELVARGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVTSFVEALNTALGRRGLDYGIAAEHAHSCCVLLASKRFLVDGRWHTLI
DYEKFFECLESGEEFAPEDYMGPLTPEWATWGHGGFDPADERVYRKAKKVAQEMTRSTDR
EDEA
>A0A1E3B0K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus cristatus|TrEMBL
MDCSSAMLEGAVTFWHAYRLPILVTLSTLFVIIQAYRKLQPKSKTEASSSLPPSPRSHSP
EKSEKIPVSDGTKKDTPVVSKSTGPKVVTGKKPVKGGKRGSDEPQPLSFIQPIVFFASLT
GTTERYAHMLVEELRAAAQNRADPENRERGLLPPQLHDLSYIDFDNFFTSAPKPPSTSPG
TRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTGSLSQLAGYSVFGFGDKEGWPTEE
EGYCSQAKELDRWMAKLTGKKRAFPLGLGDVKDNAEQALKEWSHGLQDILYDILQNGGLG
EGVPGSGDPLESDEEDLDDEDETDVAKPKSKRGKGQSSTVVDLEDIKVNPDSPAPLAVDF
TTGGKSSEPHAKEMVPKTSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGIKSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDDPDMIFNGVKDGHYKKIKM
LRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDLLHSEHISSFLVCNAQHPDQ
LETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRNVQRTVFRLTLV
KGFNVEDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEEITEFVIAL
NKELERRGLNYGLAAEHAHSCCVLLASDRFHVNGKWHTRINYERFFELLEKEKADGSSFT
PEDYMSETTEWALWGNGGFDPNDERVYKKGKKAKAQQAQQQLANSTPNEA
>A0A2A5P0G0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Geothermarchaeota archaeon ex4572_27|TrEMBL
MCCWRGAVGVERRVLKIPEDLARKLRKAHYGVYNHSTVEICHWTKKSLKNEGDCYKKIFY
GIDTHRCVQFSPAGMICNMKCIFCWRPAEFMERISMSPDEVDDPEELMEGILRERRRLLS
GYPGNPKVDMRKYREALAPNHYAISLSGEPTLYPKLPELIKYLRSRPLTRSIFLVTNGVV
PEMLERLMNEDALPTQLYISMNAPNERLFRAINRPLVRNAWRLWLRSLDLMAEMKTRTVI
RFTLIRGLNSDEKYMQQYAELIRRANPHFVEIKSYMHLGYSTRRLKAENMLDHSEIKEYA
EKLLRYLPEFSYMDEHPPSRIVVLQNEERKVDRFIP
>A0A2N1NQ79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis|TrEMBL
MDIVEYETEDFLSESAICIFLISTYNVEGPLDWFYKWLEDTRYDFRVDKQALSKMKFAIF
GLGDSAYGDQFCIQPRNIDKWLGQLGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDP
SYALNNVSSNLNYDSYSESDSDSDNNNNSDTEMVDVEDIGALAPKLQAARKSKEKEEFVY
KNSNGRPKRTLSEQEVPINEPKEMVTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGR
GSCYKFCFYGIQSHRCLETTPSLACSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLS
NHYKMINEMKGIPGIRADRFQEAFNVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMV
CNAQHPSRLRALDKVTQLYVSVDASTKESLKKIDRPLFKDFWERFLECLDILSQKGQRTV
YRLTLVKDYNTEEIANYVELVRRGKPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFV
KHLNENLGDTYEIATEHSHSCSILIANTKFKINNKWYTWIDYDKFFELLEKGEHFTSLDY
IAPTPSWALFGSPEAGFNPEDQRFYRKSKKNNNSVKNGGC
>V4KFQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured Acidilobus sp. OSP8|TrEMBL
MEVRAEEDVYRLLDQRLIKQGYHLVGRHSSVKKCYWNHAALVEGRFCYKGKFYGIESHRC
IQLSVTNHWCWNACLHCWRLRPQDVGIQWNETRTPFADDPRSIVEGAIREYRRIVSGYKG
RPGVDPKMYQEATNPKHVAISLTGEATLYPMLGELIKEFHRRGITTFLVTRGVRPDVLAN
LEEEPTQIYVSLEAWDKESYNYFNRPLVPRAWELTLETLQLLPSFSSTTVYRITIVKGFN
DNDAALRGFAELVKLGMPDYIEVKAYMYVGASRNRLRLENMPRHEEVKAIARKLSELTGY
PVVSESAPSRVVLLSRLERPIRYGNAPVDWNSPDIPAPGEYEEPGEAATA
>W5PLX9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ovis aries|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNLQEKTTPKASQD
LMTNGYVFRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLDLPVAVINLKDYDPDD
CLVEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGERKRCRGNCKKGKCESNQRSSEAVEPGSHAQEELHHGDAEEEEPFGSTSEEESD
AEDHQSQNSVIDVEDLGKMMDHVKKEKREKELQEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEISFELPRDLKPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGN
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIA
HKKFKIGGEWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPK
DTRYQRKNKSKDISGC
>A0A2P5K1V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|ANME-2 cluster archaeon HR1|TrEMBL
MSSSYDLFKKQGYHIAGAHSAVKTCLWSGRSVKAQGSCYKSKFYGIRSHRCIQMTPYLGC
NQKCLHCWRPVEHPVLEPEQWDTPDEIVNNCIEVQRKLMSGYGGLDSVDKMTWKESCEPK
HAAISLAGEPTLYPYLKELVEEYHKKKITTFVVTNGTNPDVIEAISPTQLYMSLNGPDKD
TYLKCCRPNNNDQWDQILHSLKILHDHTSRIVIRLTLIKGLNLKNPEEYARLIDIAKPDF
VEVKAYMHLGYSRKRLDRSSMPEHNEVLAFANQLATKIGYYCVDQVEVSRVVLLSRSDQP
DSFKI
>A0A7J4I623|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIPILNNTTDENAKSCQSGCNAIPEGFIEVPQDINKQIDQKLDFMRKKTTEMGYRFVGNH
SAIKVCHWTKESIRGKNVCYKNKFYGIESNQCVQMSPSMLMCSFNCKFCWRNFDYILPRE
KEDWDDPKQVLDGCIDAQVEILQGFYGNPNADREKLDKAMIPQHVAISLSGEPTLYPYLP
EFIDEIKKRNMTAYLVSNGTRPQMIETLLEHQPTNLYISFYGTNPEMYKKTAIPMEKDFW
EKVNESLMMLGKFDCNTVVRLTLAKGLNFTDPKGYAEIIEKSGSKFIEVKGFMAVGGSRR
VMKYEDMPLHNEIQQFAAEIERHSSYNIVNEKADSRVVLLSRK
>A0A7C3M4X7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIPQEAKQRFFKAGYRIVGNHSAVEVCHWTKESLRKGRVCFKEKWYGIKSHRCLEMTPSL
IWCTQKCKFCWRPLEFTALGEPKPDDPKEIVEGCVEARRLLLTGFKGYSKVDKKKWEEAI
KPTNAAISLAGEPTLYPRISELIEEFHKRSMTTFLVTNGTMPNRLASLEEEPTQLYISLC
APDEKTYFEVNNPLIPDGWKRLNESLELMKSFDCKKVIRLTLVKGLNLKEPEKYAKLILK
AEPDFIEPKAFMWVGESQKRLPKEAMPSMEDIRKFAKELSLHTGYEIKDEDLASRVILLT
KK
>A0A7J2VU92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MEEEKEPLLKEGKIRIDEELAKKLRHAQYGVFGHSTVDVCHYTKKALKKEKVCYKRKFFG
VETHRCMEFSPAGLFCHNRCIYCWRPTNFYKTLKLEEDKVDDPKEIFENLLKERNKLLTG
FGGNEKVDKELYKEAMIPTHFAISLSGEPTLYPKLPGLIKYLKSLPHTKSIFLVTNGQEP
EMLERLEREDALPTQLYLSMNAGKLETFKRVNCPLMKDAWERFNRSLEFLSKTKTRTLIR
ITLIKGFNDSKDEIKDFAELVKKGNPHFIEVKSYMHVGYSKSRLTEKEMLTMEEIRDWAK
ELQKLLPNFEFMDEDEDSRIVILQNKDRYVDRWIVKPEESSLFRFGL
>A0A7C0Y4B1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MVVKIGKAIETQLRNAHYGVYNHSAVQICPWTKKSIKNMGECYKNTFYGIETHRCMEFSP
AAVFCQNNCIFCWRKMEFMRNFKMEDVDEPRDIYENLLKERKQLLSGFFGNESVDRKKLE
EALGPTHFAISLSGEPTLYPKLPELIKFLKKLDDTKTIFLVTNAQEPDMFEKLKKRKALP
TQLYISTNAPNKALFKRINVPVYSDAWERFIESLEIASGMRTRVVMRLTMIKGLNMKQEL
VDGYCKLIETLNPHFIEVKAYMWVGYSRRRLKEENMPSHDEVKNYAKKIAQASGFKFIDE
RSESRVVLLQNKSNIIDRFIKM
>A0A7C3UJT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MFKIPERLKKIYYRQGYRIVGKNQHSAVKICQWTKSALRGGKQCFKQKWYGIQSHRCLQC
TAWLSCLNDCLYCWRSFKIPVSTSEVDEPKELIEEMVKQQAVLLSGFKGNAKVERKKWEE
ALKPNNAALSLIGESLLYPKISSLLEEFHKRHFTTFLVTKGTLPKQLASLTEEPTNIYIS
LSSPDENTQKLLERPLIKNAWKKQVESLKLMSSFKCRKVIRLTLVKGFNMHSIEKYVKLI
SLAEPDFIEVKAYMYVGESRKRLPESAMPTMQDVRDFASNLSLATNYKIEDDDVQSRVLL
LRR
>W9XDP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cladophialophora psammophila CBS 110553|TrEMBL
MDFGDAGAAPVILADRLDRLLISWHENRVVLSIVLGLSVLAVIVLRRHAYKIAQRGSPTL
EKAEWLSQNDDVRLQIAKDKRIETAPRNTPSLTSGQARKPLITVAAPRVVTGRKPSKSRG
GQLALQRRREPSRIQPLIFFSSLTGTTERLSKNVAADLEEVSIAQPAILRPQIHDISYID
LDDYFISGPKTPAPDAGILYFYLLLIPSYDIDTILNTFLSHLDETHNDFRIDTAPLSMLA
GYTVFGIGDKEGWPTEETGFCSQAVEVDKWMAKLTGRKRAYPVGLGDVKSNLDRSLKDWI
GGVSNILKEVSKTGALGEGVPGSGEPLESDDEDEPEEVDEEVEFPDSGRNKRRKLANTTD
LEDVGGKANSYAAPMAIDFTTYSSPPSAPTPLKAMVPKESPTHAALIKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
IDDPKLIFEGAKEGHYRKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNS
CLDLLREKRFEQRTVFRLTLVKGFNIEDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALEKALAKRGLEYGIAAEHAHSCCVLIASKRFFINAKWHTL
IDYDKFFNLLESARDFTPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEKKTTSDNGG
QNQNGTRVGEEKFMP
>A0A2R6GBS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_1_68_20|TrEMBL
MSDSDGPKQVDDPNYHSENHTAVQTCGWTKNAMRGEGKCYKNIFYGIESHRCIQMTPVVK
CNERCVFCWRDHEGHAYELGDVEWDDPAAVAEASIELQRKLLSGFGGNDEVPRDVFEQAM
EPRHVAISLDGEPTLYPYLPELIEEFHERDVTTFLVSNGTKPEVLAECDPTQLYVSVDAA
DRATFDDVVRAVDDDAWQRLVDTMDVLHEKDETRTVLRTTCMDGWNMSDPDWFASFYRRA
DPDFVELKAYMHVGHSRGRLDRSTMPDHEDVVAFAEAVMEHMPEHDVLKQVPASRVALLA
KEEETWIPKLQKDSDFWARDPVVGD
>A4FW84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis (strain C5 / ATCC BAA-1333)|TrEMBL
MIPEQIHNILRKQHYQLKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPEWKEPEVVAEDILSMHKTIITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDNWESILNTLDILDSKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQDELLEMGKILGENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A8J7X8L6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeota archaeon|TrEMBL
MIDEETREILQKQHYKVVGNHSAVKVCHWLRKSIRDEGHCYKQQFYGIKSHRCLQMTPAV
VWCTQKCVFCWRNIEKTAGITLEEFDEPTKIIDAAIEAQRKLISGFGGIPERINRKKFKE
AQDPNQAAISLAGEPTIYPKISELIGEFNRRDFTTFLVTNGTLPERIEAMDNLPTNLYVS
IDAPNEEIYRKTCNPIIPDGWERFNRTLDLFPSMDTTKVVRITLVKDFNLVEPGLYSPLL
ERAQPDFIEVKSYMHVGSSIERLPEDSMPGFQEIEEFSRILAEDISYDIKDWKEDSRVVL
LSKK
>B0R745|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)|TrEMBL
MSESDGPKQVDDPDYHHENHTAAQTCGWTANAMRGEGTCYKHAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHSGHTYELDGVAWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEAM
EPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPAVLRECDPTQLYVSVDAP
ERATFDDVVGATEDDAWERLVDTMDVLHAKDDTRTVLRTTLVGGQNMANPDWYAGFFERA
APDFVELKAYMHVGDSRDRLGRAAMPDHEDVLAFARAVKTHLPHSVLREQPASRVALLAR
DEDTWVEDLQPESAFWTEGARPTAD
>A0A835XAY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MSCSGESVEVEDQLIQIKPGMLQALKKAKYGVADHSTVDLCHYTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEKVAEPEEIVTKLMQERRKLIV
GHYGDSRNDKKKIDESLIPHHYAISLSGEPTMYPKLPGLIKYLKSLQTTKSIFLVTNGQE
PEMLQKLADEDALPTQLYLSTNAANYESFMRVNRPKYKDSWERWNTSLKMLSKLNTRTVL
RITLIRDYNDQDEIIPAYSSLLRESNAHFIEVKSYMHVGRSTNRLEHSNMLEMDEIRHFA
EKLAKQSGIFSKMDESVISRIVVLQNQKRFIDRLIPSYVQTN
>A0A0V1M9A0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella papuae|TrEMBL
MFERTLHAFCPSDMITFNLCESVLIIVGISTALIVLLLYIIMKKKEKHREDVKIFFASQS
GNAQKLAYSLHSRLKSTFSTAVFDLQHYDPEGHLENEQAVCIFIVSTYVDGQCPEKCRWF
FKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYRNTFNKVAIKLSKHLLLLKANNILPLY
LTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSLHDNKRVSVWRDENENSSDAEDAENN
ANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYK
HTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPADKILFDSLEGHKKM
VRQFRGVPGVKDARFEESATVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQF
PSAIENLIPVTQLYLSVDAASKESLKEIDRPLTVYRLTLVNQYNMNEVSQYAALIKRGQP
DFVEVKGVTYCGDSKNSKITMANVPWHADVVDFVQQLVFQLDDYDIAAEHEHSNCVLIAK
LNFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQR
WYRKSKVS
>A0A1Z9NGL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED215|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFYKLEETLELLPSLDTRTVCRHTLIKHESMGHHDDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEVLEFSQKLAPMVGREVLSDRRESRVALIGK
EMIPVELPVANTELPKDLGIAKPQRFLLPQA
>A0A100XYT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus celericrescens|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPSQLYVSLTAPDIETYNRVNVPMVPDGWDRIKETLRLMKDAQTRTVIRLTLVKGE
NMNNPEGYAKLIKLANPMFVEAKAYMFVGFSRQRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHRTGIGGRFIKH
>A0A851DWG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dryoscopus gambensis|TrEMBL
LDVSMDTWNYFHTCLVSIWLHRFYIYSVVAFGISLWIVVQITTTRTKRKKSHGNPTSSEG
TADKLGNGCAPPQPQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVVNMGDYD
PEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSRKCKKGKCKSSGKQSKESSDHEHGTSEYENSEAEQLFETSSEEEA
GGIDSVIDVEDLGNIMGHMKKAKVLLLEGVWNGQGARLQEHPAAAHPAALCLAHCCPGCL
TTFALFSGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALSVKHC
ALSLVGEPIMYPQINHFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKES
LRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKF
QVDGEWRTWIDYGRFQELVRERERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRY
QRKNKARDISGC
>A0A091UHP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaethon lepturus|TrEMBL
LDVSMDMWTFFYICLASVWLHRFYIYSAVAFGISIWIVFQFTATRTKKKSEKSTVNPAAS
VGIEDTLVNGYATLQAKEVSVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGD
YDPDDCLAEETSSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRVGKTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLGRLQALCRGEKKPCSGKCKKGKCKSPGKQRKEGSDHEHRASEYENAEAEDFFETSSEE
EADAEEAGGTNSVVDVEDLGNIMSHMKKAKRERELEEGDTGTGLPHENAGRKEEGEKREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINRFVQLLHQHSISSFLVTNAQFPEEIRNLGPVTQLYVSVDA
STRESLKRIDRPLFKDFWQRFLESLKALSEK
>A0A8B6FX78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilus galloprovincialis|TrEMBL
MLEKLLSSYIFESFQIPVWTLLLATICLIWMWNSGRKNENSSEKVEDQKSTELPITNENV
IELHANSRQKITKKRKIKIFFGTQTGNAKMLADNLCREATERGHEAEVLDLKTYDPEDNL
VTEGENGVWVVLFISTYTDGTPPEGSEWFCKWLEESSTDFRIPKALLKELHYAVFGLGNS
LYTENYNAVGKKVDRFFRELSAKPILPVGLGDENVAESLKGGMEKDFTAWKKEFWKKSKK
VKDNDTVVTDTCGTGKKTCDGKCKCKEDGGKCSSEEEEEEEEGEDLYETTTEEEDNAEEL
LNEDGDGSSLQTTNGVVDLEDLGKVMQTMKKAKVRRKKEESAQSTGEPREMVTPMLKKAL
EKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDDANTVFQGALDNHVGLIKQFKGVPGVKAERFAEGLEPQHCALSL
VGEPIMYPEINKFIELLHGKGISSFLVTNAQFPDAISNLVPVTQLYVSIDASTKESLRKI
DRPLFKDFWERFIDSLKALSAKRQRTVYRLTLVKA
>A0A2G9M1S8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_45_5|TrEMBL
MVKEQLRKALEKQNYAVFGRHSAVKICAWTKKALRDEDFCYKQKFYGIRSHLCCQMTPAL
DYCPNSCRFCWRAIELTSGAEIPESEVDEPEDILSGSIAAQRKLLSGFPGNPKANQKKVK
EAMEPMHFAISLAGEPASYPKLDALIELLHKNGKTTFLVTNGQFPEKISSLKHLPTQLYI
SLTAPDEETYRRTAVPTFKDAWQRLNSSLEIMAGLAGKTRTTIRMTLVKGLNMHSPEKYA
ELIKKANPLFVEAKAYMYVGFSRERLKMENMPSHAEVREFAEKTGKHCGYHIVDEKQNSR
VVLLMQKDFPGRIMKFG
>A0A6A6P546|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lineolata rhizophorae|TrEMBL
MKSLLANNRPPTVLLDLWHGYRVPVILSTLTLLFAVRVVLRARWHREKVSVTPPVGSPKV
HGMGTTEQKSMLTEKETPRILSPETLLLEKEVESNLRTNEAPRRQRQSPKRVAASKIFRR
RSLKAAPYGLFDAATDKIQPIVFFASVAGSTEKTAGNVARDMEAWVDSESNAALNVLKPI
LHDLFYVDYDDYFISGPPSPLPNTKHFYIFLLPTYNIDTALTPFLDHLRETHHDFRINTA
PLSALIGYSVFGFGDQEGWPTEAEGFCSQAKEVDKWMAKLTGRKRAFPMGTGDVKSDALE
RLKDWREGVQEVLVEFAAGKGLGEGVPGSGDAVESDEEDGDGDSEDADAEQSKTSTSRRT
KKVPDTRVDDVEDLGRMVSPELAKTPPSRSSRARPLAIDFTTKITPSLTVPVPSSDPKPM
VPKESPTYSALTKQGYSIIGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMEATPS
LSCSNKCVFCWRHGTNPVGTTWRWSVDPPDLIFSGALAAHVSKIKSLKGVPGVRAERFAE
ALRVRHCALSLVGEPLFYPHINALLSLLHGRRISSFLVCNAQHPAQLAALARVTQLYVSI
DASDAESLRRVDRPLHRDYWPRFLACLDILRERRAKQRTVFRLTLVKGFNFDKEADGYAA
LVTRGVPAFVEIKGVTYCGTSSSSAAGLTMQNVPFWEEVAAFAEELVKRLNAQAESSDDE
QLRYGIAAEHRHSCCVLLACERRFKRNGRWCSRIDYDRFFDLLEERGEEGDWGPEDYMGE
DTPEWALWGNGGFDPRDTRVDRKGRPVPKA
>A0A1G4M9E6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea fermentati|TrEMBL
MNEEKPSFSVMDFALLATVLFVYLLSGGRWTIACSILVLCALAKHESSTEKLSAAAETAN
EPSAPKKKSCCGGKGGKSCCSSGGKGKKGGCCGGSCSSKAKANDSTIKNNIAKETAPIAV
DFTQAFKPVRNSKKTNGTKKIPKVFSASPSTKASSPIFKKGLTISNEKLLGSQIYVFFSS
LQGAAKRSAESLVCELSKVDGLSKIPLLMNLDEISDIDDYFVNVPCDNALYILVLPSYDT
DSPLDYFLQTLEENSSDFRIDKYPMRKLVGYTILGIGDSESWPEKFCYQARLADLLLARL
GGRRIFPIGEICMKFGGIPKVEDWANLLGNTLKDDEPILYEFDENVDNDDDDTAVEDLTK
ESVMDLEDIGKSSELAMNEVKKMVAQNSPTYKNLTKQGYTVVGSHSGVKICRWTKNDLRG
RGSCYKHSLFNIVSSQCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEIDEPEYILENAL
QGHYSKIKQMRGVPGVIAERFANAFKVRHCALSLVGEPIMYPHINKFVELLHEKEISSFL
VCNAQHPQALEDLGKVTQLYVSIDAPTKTELKKVDRPLYRDFWERMLQCLNILKTTQSHQ
RTVFRMTLVKGFNMGEVSAYADLVEKGLPCFIEVKGATFCGSSDANGNPLTMQNIPFYEE
CTSFVKEFAKELQRRGLGYDIAAEHAHSNCILIANTKFKIKNEWYTHIDFERFFKLLKSG
EKFDHLDYISKTPEWALFGNGGFAPGNTRFYKKASKQKSNISEESAKIEIAA
>A0A843EMX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MAFTKEEQAKLEYSGYRFVGEHGHAAAKICHWTRKSMVNEGVCYKEQFYGVQSHRCLQMS
PAVPFCNQKCSFCWRDLSQTRIEWEGEYDDPKTIIEGAIKAQNNLLCGFGGNKKADKKKL
EESKKPTNAAISLAGEPTLYPEIDELIAEFHRQDFTTFLVSNGMYWEKLGNLDNEPTQLY
VSLDAPNEKVYKELCNPQINDAWSNLNKTLELMNSFNSRTAIRITSVKGKNMINTDEYAK
LINKANPKFVEVKAYMFVGSSRKRLSLDNMPSHQDVRDFAQEIADKTGRELTKEAEVSRV
VLLE
>A0A8F2VYH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida auris|TrEMBL
MTSGTPILAICSLIYWLTGGRITFVAAAWCALWFHKGKLQPFSAASSAPPITKPVKSSRI
MEVDFTNSFTPDSKTEFPKAVPLKKKTRRTREPKIFKAAAKSGKPSKGVSHLTTNSVQLK
KCPIYIFYTTLTGSSLRVAKALHQKMANIDGIEVPPRLLSLDDDVDDLEEYFLRTPKSEN
PPVYLLVLPSYETDSPIDYFLEHLTDTYQDFRVDKYPLRTLAGFAVLGLGDSESWPGSQF
CYQAKSADKWLGKLGARRLFPVGEVCMKHEGEPKSQDWINGFSELMVDDQPFFFEDDPAA
FDSDAGSDEEEAQAEDENVVDVEDMGAIIRASKNKDAAVAEPKQMVAQDSPTYKSLTKQG
YTIVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGT
NPVAKSNWRWEVDPPEKVLEGALDGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGE
PIFYPHINEFVGMLHSRHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKNDLKKVDRP
LNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGA
TFCGSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTK
FKINNVWHTHIDYPKFFELLESGADFCDLDYIQKTPDWAIWGAEEGGFNPADTRYDRKAE
KLKKKQARDEAAAKALQAKKSESIKASSEFSEHTRELFVS
>A0A510NYR4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida auris|TrEMBL
MTSGTPILAICSLIYWLTGGRITFVAAAWCALWFHKGKLQPFSAASSAPPITKPVKSSRI
MEVDFTNSFTPDSKTEFTKAVPLKKKTRRTREAKIFKAAAKSGKPSKGVSHLTTNSVQLK
KCPIYIFYTTLTGSSLRVAKALHQKMANIDGIEVPPRLLSLDDDVDDLEEYFLRTPKSEN
PPVYLLVLPSYETDSPIDYFLEHLTDTYQDFRVDKYPLRTLAGFAVLGLGDSESWPGSQF
CYQAKSADKWLGKLGARRLFPVGEVCMKHEGEPKSQDWINGFSELMVDDQPFFFEDDPAA
FDSDAGSDEEEAQAEDENVVDVEDMGAIIRASKNKDAAVAEPKQMVAQDSPTYKSLTKQG
YTIVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGT
NPVAKSNWRWEVDPPEKVLEGALDGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGE
PIFYPHINEFVGMLHSRHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKNDLKKVDRP
LNSDFWERLMACLDILRTTQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGA
TFCGSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTK
FKINNVWHTHIDYPKFFELLESGADFCDLDYIQKTPDWAIWGAEEGGFNPADTRYDRKAE
KLKKKQARDEAAAKALQAKKSESIKASSEFSEHTRELFVS
>A0A384LP61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium knowlesi (strain H)|TrEMBL
MVQGDDEKKRRNLLQTIFEQHAVRKRKKAKINLRIVYGSEGSNSYRKARGFLKELIQFFK
DIENICNEVNRIVSEEGGSHPIFFNGRTNEVDHGENRLMRYFKEYSKLLQGKNEQTARTG
KKDKFHTEGVINSVHEVLEEFQEKEKKCSDKFVNYLDCCISNNVCTVNFDFVNGNEFNDY
SFFEHTTEYDLNVMVLFVSTASNGSFPRNCYKFEQLLEDLYNDFRVEKNFLKNIFYTCIG
FGNKQYGSTHFCTPVKKCDKYLTSLGAQKLFKTLKLCDEENNEEVFLVWKCTLFKTISLG
LLFYCFNFLHLGSFMPYADRKIYNSLQHYCFFFCGKAENRKGKKENIKMGTTHAASIQVP
QEHGNQIHETVQKGESSQAGDPLTGIVPKGDPSTKVLCSTCGEGTSDRCTSDRCTNDGYT
HLNGDEWEGMPTTEKSEDEMVEKSTHTYKKKEDLKISTSLCSSGEELEDLVPDKPKDMLT
WNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGCYKHTFYGINSYQCMEATPSLACA
NKCVFCWRHHKNPVGTHWKWNKDDAEMIVDEALKKHKGMIKELKGAHGVIKERFDEAVNV
RHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNAQFPNELQKLHKVTQLYLSIDAPN
EEALKNIDRPLFKDFWDRYIRCIKILKKRKERTVFRFTLVKEYNMMSEEILSYSKLIEYG
YPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAYSLIHSNGYLPDVYEIACEHRHSC
SILIAKKEFKINDKWHTWIDYEKFQFLVKQNKDFTALDYCAETPAWAVMGAEERGFNPCD
ERVYTKGKKKNKPPITENTSQS
>A0A673KJZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
MICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTFLKGMRYAVFGLGNSVYVGHYN
TVSKNIDKWLWMLSAATHMCPPKLTALFGFQEELMESSSDAESSAEEEKSRGSVIDMEDL
GNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQFRGV
PGVRPERFEEGLTVKHCALSLVGEPIMYPEIHSFLRLLHQQNISSFLVTNAQFPEEIRSL
VPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVD
ELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEI
ACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSW
AIFGARERGFDPSDTRFQRKNNTKDISGC
>A0A2R6M628|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_7_65_23|TrEMBL
MSDSESGPKQVDDPNYHSENHTATQTCGWTKNALRGDGKCYKNIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQTKLLSGFGGNDQVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTKPDVLDECDPTQLYVSVDA
PDRGTFDSTVKAVEDDAWERLVDTLDVLAAKDETRTVIRTTLVRGHNMHRPEWYAAMCQR
ADADYVELKAYMHVGHSRGRLDRDSMPDHEDVVAFAEEMREFLPHDELKQVPASRVALLA
REQDTWIPKLQKSSDFWARDPLAE
>G4RM44|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)|TrEMBL
MSCEEEPIGRHHVLEGPKLRIKAPTVRRLIEAHYGVYGHATVELCKWTKDALDGRGSCYK
VKFYNAPAGGSHRCVEMSPVGMLCDNRCIYCWRPTQEFDSFVPEELWVMEPEEVIRGVLK
ERERLLSGYWAHDPERVKEALAPTHWAISLSGEPTLYPKLPELVKLIKSLPHTKSVFIVT
NGQHPEMLERLIKEDALPTQLYLSMNAPNKELFYEINVPILNKEDAWERWLKSLELLAAM
PTRTVVRITLIRSMNYDERLIPQFAELLKRGNPHFIEVKSYMHLGYSTRRLSRNDMLTHQ
EVVEWAKRLRDELERAGARYAYMDDDERSRIAVLQNMDRYIDRWIVPPGFNGSS
>A0A832W0D5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methermicoccus shengliensis|TrEMBL
MSDEEYWRLLRKHGYQRVGAHSAVKSCLWLKKALRGEGMCYKGRFYGIFSHRCIQMTPTL
MCNQRCMFCWRPVEVEPPAYGWDSPSLIADGAIEAQMRLLTGYGGSSKTDGAALREAHTP
RHVAISLAGEPTLYPYLDELIREFSSRDMTTFVVSNGTCPEVIEKISPTMLYISLDAPDE
HTYRKVCRPIANTWNRVLESLELLPQKRCRTNVRITLVRGLNMHDEAGYATLLEKAQPDF
VEVKAYMHIGFSRNRLARDAMPAHEEVHAFASRIAHFTGYTLVDEVPISRVVLLARDDRT
PRWISGVGHE
>A0A7C3SPF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum pendens|TrEMBL
MAVTLDVQRYLRAGYKLVGGHSAVAICRWXRSALRGERFCYKNWYGIRSHRCLQMTPVLN
FCDFACKFCWRMHLPGRYQVPRGWQWDNPQEVLDKSIIAQRLLLIGFKGNPLVTKERFLE
AMFPRHLTISLDGEPLLYPGLAGLIKEAKERGFTVFLVTNGSIPARLRELVKKDAQPTNL
YLSIYGPNREVFERTVDPRIPRAWEMVNESLGLLREFRESRTVMRLTLVRGLNMVEPEGY
AELVRSGEPMFVXLKGYTWVGESQKRXPITAMPEMXELVDFASKLSELTGYQVKLTDDKS
RVVMLVRDEESWERNLKMVEKWRRRERELDERVLSKVEDFTMEEHGYKILRY
>M7TLA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryotinia fuckeliana (strain BcDW1)|TrEMBL
MAYDSWISRPVWSFGIDDVVALWHLYRIPIILTTATILILVRITLRPRALREKLSASPLP
TSPILSAAKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTANSFVKSLTRDLSGRANEQRIQFLESQLLDLSYIDYDDYFINPPKGESGTSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVDDVEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTASEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTG
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASNRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDAGEDKVAEDSTKDDLAF
>A0A0B5HQK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeon GW2011_AR10|TrEMBL
MKGQVAVTDKGQAEIASKEIAKLPDYVVKQLHAKKYAVVGNHSAVQVCTYNKKTFKGAEP
CYKEKFYGIDCHRCAQMSPAAMWCNENCVFCWRPMEFMKDVNLDNKIVDEPRDIIDGVIK
SRKKLLSGFGGLPGLHEQKFKEAQLPSHWAVSLSGEPTMYPKICELIVEIKRLPDTKSVF
LVTNAQLPQVFEKMASNEDFLPTQLYVSLDAPNEALFKKINRSVFKDGWERLNKSLEVIG
KLKVRRVIRFTIIRGLNDMPEMAADWAKIIRKANPEFLEIKSYMHIGMSRQRLNRENMLL
HPEVKAFAEKIAEASGYKYSNESVLGRIVLLVRPDLEGKSTKIVFNSA
>A0A4W6CX46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDPDD
QLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLG
NSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRL
QALAKGEKKSCSGNCKTGGTCDIQPEPSAAENCESSSDEDESGLQDEKKSGSVVDMEDLG
NIMNSAKKAMVRLHPLKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQD
AVEKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISS
FLVTNAQFPQEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQ
RTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVV
AFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYERFQELVQAHEESGGQ
QSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A838D5M0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEIYSHSNTGNDLIQITPAAKQKLKKAKYGVFNHSAVELCHWTKKSFSDGGSCYKH
KFYGISTHRCMEMTPTALNCENRCIYCWRPTEFYDTLEMPAHLVDDPEIIVQNLLEERRK
LIVGYYGKTDVNVSKLDESLFPEHYAVSLSGEPTMYPKLPELIKYLSKLKATKSIFLVTN
GQEPEMLYRLASENALPTQIYLSTNASNKNMFYKINGPKHRNAWERWLQSLDFMSQVNTR
TVLRFTLIRNFNDNPTFFKDFAKLVEIGNPHFIELKSYMHIGMSTNRLEESNMLEMDEVR
SFSAGLKTHLEDYSLMDESVVSRIVVLQNKARFISRWIETYP
>A0A7C2TL62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEIVQEEDELIQIKPRVLQQLKKAKYGVADHSTVQLCHWTKKSFKNDGDCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEKVAEPEQVVKKLMEERRKLIM
GHYGDSRSDKNKLDESLLPSHYSISLSGEPTMYPKLPELIKYLKSLKETKSIFLVTNGQE
PDMIKRLADEDALPTQLYLSTNAADYESFRKINRPRYEDSWERWNSSLEMLKELDTRTVL
RITLIRDYNTTDEMIPAFASMIRNASPHFIEIKSYMHIGRSTNRLERENMLELDEVMHFS
SELVRQSKIFSVMDESQISRIVVLQNQERFTDRWISSYLDTN
>B3S4K3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoplax adhaerens|TrEMBL
SRQICIFLLSTYTGGEPAESARWFYTWLQDTVSDFRVQKTLLSKLNYAVFGLGNSVYQEH
FNSVAKDTDSWLHKLHGNRILPLGIGDNNVVQSENGGLEEDFVAWKGRILRVLNLEITPS
HKPVDNEVNVAPSKIKVKENVIHEGKITSESSDNSEDEETIAMKKNSTIPIKNDVVDVED
LGVMLNNLGKAKADRELEVSTLQRVQAGPKTSISSLKKAELRDMVTPSLKEALSKQGYKI
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPV
GTEWRWKMDDPEKIFNEALKNHYGLIKQFKGKLGHLRIRTIILFCKHNGKNLTDFLGVPG
VQTERFKEAMEVKHCALSLVGEPIMYPEINKFIELLHGKEISSFLVTNAQFPNAIRDLTP
VTQLYVSVDASTKESLKKIDRPLFKDFWPRFLKSLSALSEKGQRTVYRLTLVKAWNAEEI
EAYANLVGYGNPDFIEVKGVTYCGESKASKLTMENIPWHQEVLSFTDKLVDNLPEYEIAC
EHEHSNCVLVAHKKFKVHGRWHTWIDYAKFHKLIAEFASNGGKNFDASDYMALTPDWAVI
GHPAHGFDPVETRWHRKKNNKDIGGC
>A0A1H1GF59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronobacterium texcoconense|TrEMBL
MSDSADSGVDPGTDVGEDGDDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNI
WYGIESHRCIQMTPIVKCNERCVFCWRDHRGHAYELGDVEWDDPEAVVDASIKLQKKLLS
GFGGNEEVPREVFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTNPD
VLRECEPTQLYVSVDAPERHTFDQVVKAVEDDAWDRLLETMDVLAEKDETRTVLRTTLVK
GENMHHPDWYAGFYGQADPDFVELKAYMHVGHSRGRLDRTSMPDHEEVAEFAREVAKYMP
EFTEVKEVPASRVALLSKTSDTWVPKLKKDSEFWQRDPVTGD
>S6A5R5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum adornatum|TrEMBL
MESTQRMEVARYLRAGYKLVGNHSAVAICRWTRSAIRGERLCYKSWYGIQSHRCLQMTPV
LNFCDFACKFCWRMHLPGRFKIPNGWRWDEPEDIINGSIIAQRLLLIGFKGNPKVTKERF
LEAMFPRHFTISLDGEPLLYPKLPDLIKRINERNFTTFLVTNGSIPMRLKEMLKKDAHPT
NLYLSLYGPNKEVFQATADPKIPNAWENVLTSLELLDQFKKSRTVIRLTMVRDLNMVEPE
GYASLIKKANPMFVELKGYTWVGESQKRLPITAMPTLDELEKFAEKIQEITGYKIKVKDD
KSRVVMLVRDEEAWETNLKMVEEWKQKVSRLDENWKSKVEDFTMEEHGYKLLYY
>A0A0V1EXD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LLINNTKLCHVELDNTENIWKAYYKMFERILHVFSPSDMITFNLCESVLIIVGISTALIV
ILLYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGH
LENEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAY
RSTFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFS
SVHDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIKEML
TPTLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLAC
ANKCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESST
VRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAA
SKESLKEIDRPLTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCGDSKNSKIT
MANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNVTIFKINGQWYTWIDYEK
FFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A2G9MYE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon CG11_big_fil_rev_8_21_14_0_20_33_24|TrEMBL
MSCSGEIVDEERLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVSEPKEILTKLMEERKKLIMG
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEP
DMIQRLQDEDALPTQLYLSTNAADYDSFLKINRPKYDDSWQRWNKTLEMLKRLDTRTVLR
ITLIRDYNDQKEMIPAFASMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVRKFSE
EVAKHSQIFSIMDESIVSRIVILQNNQRTINRWISAYSSTS
>A0A8H6C0R4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida albicans|TrEMBL
MGFGQILLFACSILYLSTGGRWTVVALVFVLYILYNKDQQQQQQPPQPQQLKPSVPPLAK
PKKESPIYAVDFTFSSKAFTPSTTTTFPIRRVIAPRPKRSPKIFTASKPIVQQQQQQQQQ
QRQPVLTKTTVELKKCQIYIFYTTLTGSSQRIAKSLYEKLQNLENLELEPKLLSLDDDVD
DLEEYFLNVPTQNDNNCIYLLVLPSYETDSPIDYFLEHLIDTAQDFRIDKYPLRKLIGFS
VLGLGDSESWSHDNKFCYQAKLADKWLGKLGARRLYPLGEICMKYEGEPKAQEWIQNFAS
LIVNNDNEPFYIDDNNNDDDIDDSDAEESEGSDDADTLVDVEDMGDIIRKSGKATTIGGG
GIETKEMVAKDSPTFKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHL
CMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEKVMAGALEGHYQKIKQLRGVPG
IQMDRFEEAFKVRHCALSLVGEPIFYPYINEFVGMLHEQHISSFLVCNAQHPDSLAKLTK
VTQLYVSIDAPTKKDLKKVDRPLNSDFWERLMSCLDILRTIQSHQRTVFRLTLVKGFNME
DIESYADMVERAKPSQIEIKGATFCGSSNGNGNPLTMQNIPFYEECKNFVENLNKELQSR
GLDYDIAAEHAHSCCILVADKKFMINGKWHTHIDYPKFFELLESGKEFVDLDYVKETPEW
AVWGSQGAGFNPEDTKYDRKAEKLKKKAIRDEQAKKLVEQQQQQQQQQETVQAKR
>A0A671WH60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sparus aurata|TrEMBL
MSIWHNRLYLYSAAALVFGIWFSLKVALKKKSFSKDVGTLVYRAVKNNDRDTVVHLSGVK
IFYGSQTGTAKGFAQELSEEVKTLGIPAEVIDMKDYDPDDQLADECSNKSVCVFLVATYT
DGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLW
MLSGMRVMTRGEGDCNVVKSRNGSVQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGS
CKSKRRDTQEEEEEEEEKEELIESSSDDEESGPQDEEKSASVVDVEDLGNIMNRYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTE
WRWKMDPKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSH
HISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALG
EKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWH
QEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQTHEE
SGGRQSFSALDYTAKTPSWALFGANEQGFDPADTRFQRRNKTKDISGC
>W6KK68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytomonas sp. isolate EM1|TrEMBL
MLIGLLLYGLLFFGLPFVVLRFFVNRHLPQPASPPRSHGDVSDALTNSSLGKSSAQEDST
APRRRTFDKDERIGANNTSNTEKKDLTPKVVIAYATYSQSSLILAHKLLNFLTNILQEQD
SYSKSTCACASNGESSLSGGCACSSGRARGETKPSSNGKEGASSSSLPNSLSCGCARRRV
APIVKVLELAEDPVSGDSAGSGNRTGGLTTFGVDMLLEDPSYVLNIFIVSTFSEGKAPPR
SQAFEIILKDAFEDHRIPRDALARKRFAVFGLGDLAYGANHFNAFAKHLHEWCRGLGAPS
FVVPPVYASQFNTASLFQMFTLTLERWVRRTTFYDDYSIHSERRGGAKRAIAPGGSRSVS
SARSSRAPSEAAVDFSSDEEGEGAQTGDAEAVDDVEDLVSEAAVAPVDPDAPPPPLLYPK
LEQNLTKQGYRLVGSHSAVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACANK
CVFCWRHHTNPVSRSFRWRQDPPERLIAGGMAAHYQMIKQMRGVPGVTPERLAAAMEIRH
CALSLVGEPIMYPQINAFCGLLHARRISSFMVTNAQFPEQLRELRPVTQLYLSVDAATPE
ELRRIDRPLFEDYWERCLACVAELRRKRQRTVFRLTLVNAYNSENVVGYADLVERAWPDF
IEVKGVTYCGTSPTSTLTMKENVPRHEEVIAFCEKLCEELARRRPGYVATTMVGAERAEG
KAEEEEEDGEDPEAVLLPPGAASRPYHIACEHEHSCCVLIALDKFYFNRRWHTWIDYDRF
HDLVAAAEARRKALPEGEEDEETFTSLDYAAPTPLWATYRSKEKGFDPEQTRVIRKNGRP
GAVTSGC
>A0A420IJ47|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Golovinomyces cichoracearum|TrEMBL
MNSAGWNLKQLWSQVTKTNRGQHSNSVDPVELWHIHRFSIFLIILTIFVSLKLLFYFRAT
RENHPPTVSNPKIVSIEDSKKFPEKDQTSVQGRVPKRIVGGLKNSRVSPTTENVSNQKIT
VLIFYSSVTGTTKKIAQDFTESLARSSEKLDNFGRNIFLKPELIDLAQIVFEDYFLNFGP
SNTNVRHFYLFLLPTYNIETILDSFLEHLRETHNDFRIETAPLSPILGYSVFGFGDQDGW
PTEKDGFCSQAIEVDKWMARLTGGKRAFPLGMGDSKIDATENLEKWKEGIEDVLKHIAST
GSLGEGVIGSGDAEESDLEETDDDQGSDRKLKQSHRTKKRIEKKDTQNDLEDIGSTVNNK
STDNSPQEINFTNYGSKSPPIIKEMVPKGSPTHKALTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPELIFNG
VKAGHYQKIKMMRGVPGVRSERFSEAMRIRHCALSLVGEPIFYPYINEFLAMLHAEHISS
FLVCNAQHPDQLASLKPVTQLYVSIDASNRESLRKIDRPLHHDFWERFNRCLDILRQRRF
EQRTVFRLTLVKGFNIEDEIVGYADLIEKSLPCFVEIKGVTYCGTSSAAGAGLTMQNVPF
YDEICTFVESLDKELNRRDLDYGIAAEHAHSCCVLIASKRFQKHGKWHTRIDYDKFFRCL
ESGEKFRPEDYMGLETPEWATWGNGGFDPRDERVFRKGKNKVPFSLIESKPGALSIKQ
>A0A1E1KPR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhynchosporium commune|TrEMBL
MAYNSLVLRPLLPFEITDIVALWHSYRIPIILIAVITLLIFRTYLHLRFPRHKLTGTPPI
SPSLLALKEKPLPAEKKPPAEKVPRRIVGGLKKRKSSQEEIKPTAQKIQVLVFFSSLTGT
TEKTAKVFTESLAQNTKKLGATTSATFLEPEILDLSYIDYDEYFINPPKSDSGAQYFYLL
LLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQA
REVDKWMAKLTGRKRAFPLGMGDSKKDAADRLAEWKEGVEDMLAHIAATGNLGEGVVGSG
DAVESDVEDLDDDEDVLFDEQNVAIRKTKTKKKEALNDLEDIGSTLNKTEAAEDDDDDDE
ELELDFTTYSKKPVTKTAVAVIKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNG
VKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISS
FLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILKERRF
EQRTVFRLTLVKGFNIEDEAEGYAALVAKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPF
YEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILLASERFRVEGKWHTRIDYEKFFKCL
ESGEEFRPEDYMGSETPEWATWGNGGFDPRDERVFRKGKNKVALTERQGEVMEI
>A0A0E0P1Y2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza rufipogon|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A1D3S1P1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium chabaudi chabaudi|TrEMBL
MVTKREDELVLPPNEGGNINTYSIQKKTKINLTIIYGSEGITSYKAAKEFLNELIDFFNN
ILNHFNTISTITKGDNKNNTIFEGSISNEINNIEDYMLEYFRSKLLKTNKKNKDGKFVKK
CKNEKTDNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCSIENNISEIHFDFVN
GNEFDSYTFFENSENNDLNILFMFISTYNFGAFPTNCYKLEDILTDLVNDFRVEKNYLKN
IFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLTLCSTMDNDEEFIHWKSSL
LKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSEPINDDEKQASKSVD
NNNIHKCDCIRNGVSSEHFDQSKESGNDHNKLTNKINGHISFSTSKMDANNTEKCGCTSS
NCLNGNDKYINEKEVINNNFETSIVNGCCKNEYEQDGELINSDFSNESMNENNDEINCNS
SEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKAQIRGRGGCYKHTFY
GINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKEL
KGVHNIINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNEL
KKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKERKERTVFRFTLVKEY
NMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSK
RSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNFSAIDYCAET
PEWAVVGAPECGFNPSDQRVYTKGKNKNKNNINTMEVKT
>A0A7K7K8H7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Agelaius phoeniceus|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTTRAKRKVTEPGASDKLG
NGCAPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEIINMEDYDPEDGLV
EEVDPSQVCSLPWTPPALCCLSWGEWPKTAPKTGGVSAVPAEGTVTALVLLPHQCWYKPV
ARRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTRLQALCRGEKKPC
RGKCKKGKCKTSGKQSKESSDREDGTSEQDNTEAEELFESSSEEEAGGTDSVIDVEDLGN
VMSHMKKAKVLLLEGVWNVHSVNHSGYHLVYFMCQFLQAKLSCLMICALFSGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWR
WRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINH
LVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRF
LDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSL
TMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHCKVSLSG
>A0A3M7DNJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPEELLFLWHAHRAEVLLSAGLLFAVLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPAVQRPKPGPKRVTGTKKSKATASQEAQVVEKVQPI
IFYYTLGGSTKVYAESVAQHLAASSPSSILEPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKDEADIMLKEWTEGVSGIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETPAPRKPKRKAANRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINDLLAMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALANRG
LDYGIGAEHAHSCCILLADRERFYRIPEAEKDNPAAEKKWHTLIDYPRFFDCLESGKPFA
PEDYVGAPTPEWALWGNGGFDPRDERVDRKGRPKEQPKVQEVQE
>A0A2R5GK32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hondaea fermentalgiana|TrEMBL
MSETGRAVAVGVAAAVGVAAILGWKGVLAARESGAVEEAIEKAAGAVRDAAEATVKAVNA
AATPLLAKQEDAGAKTKVVYATTTGTAKRVAEIIAEGISGGEAVSADVYSFADDLEDEAV
VIFVMPTWTDGDAPESGQPLLAWLEDMVQDFRVDKSRFLGKVKFAVVALGSREYGKGLFC
RTGWRLDEAVGKLGAQRLCLPILVDDSDSRAKIDNLGGRVRAAIERNETVALPEKPNRGQ
RRKAMLEETKASPLDDQEDRVNEMMLDDMEDIVVVGNTAAEPGAERPDMVTSSQRKALTK
EGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVFCWRH
HKNPVGREWRWKEDEPDVIVEQAVDLHCNMIKQMKGVPGVKPERLQEAFNVRHCALSLVG
EPIMYPRINELIDELHARQISTFLVTNAQFPDAIRNLQPVTQLYVSVDAATKDALKEVDR
PLFKDFWERFTGSLESLRDKGQRTVYRLTLVKQWNMMEDELDGYAKLIELGQPDLIEIKA
VTYCGKSDASNLTIENVPWHEEVRMFAEAICKRTNGAYGTASEHVHSCCTLLARKDIYLA
PDGETWRTWIDYDRFHELVAEYKASNGEKKFTSRDYLADTPEWAVWGAPEEGFDPVESRF
RKARKSTADDASTASVRPPVGLPPSKARLARESKNLEDVAE
>A0A0F7TMJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium brasilianum|TrEMBL
MADFPKEVPLVPLFGFRPSTLSFIFFLHIFCAATLVGVIGKIPTMASSPTLTDGLLAAWH
TYRLPLLIALSTLFVALHTYRKVQSRSKTPTSSSIPSSPRSQSPAKSPILHVPTEKQPPP
LIPTNNGKLTHNDQPPKSTSGPKRVQGKRPAKTVTGRRTTSEERHPLSLQPVIFFASLTT
TTERYANVLLEDLRAVAQERADPENRESGLLPPQIHDISYIDFDDFFAAAPKPPSTSPGT
RYLYCILIPTYNIDTVLNTLLGHLDEIHNDFRIDTAPLSQLAGYSVFGFGDKEEWPTEEE
GFCSQAKEVDRWMAKLTGRKRAYPLGMGDVKTDAEISLKEWSQGLQDTIFDILESGGLGE
GVPGSGDAVESDDEELEDLEDGDESRSKKKDTSTMVDLEDIKMNGDSAGPIPIDFTTTGK
AVSAEATAKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGI
KSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFDGVKEGHYKKIKMLKG
VPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHEERISSFLVCNAQHPDQLEA
LHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHIQRTVFRLTLVKGF
NVEDEVVGYANLVEKALPGLVEIKGVTFCGTSTSAGAGLTMKNVPFYEEVSAFVVALNEE
LQRRGLKYGIAAEHAHSCCVLLASERFHVNGKWHTRIDYDRFFELLEREKQDGTSFAPED
YMRETEEWALWGRGGFNPDDERVFRKGRDADSRARKAREILGTAITF
>A0A161YNX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum tofieldiae|TrEMBL
MASSLESTGFKSMLNNAHDAWQQVRIPVILFAAFGLLVLRFYLHSTEEKGELRAIPKVYN
KEKPETKPVDEKKDVKKDIKPSPPSPTTDSKAPKSNGPKRIKGGLVKRTSSDSSNGEALA
RKIRPLIFFSSITANTPKIAKEYAERLEKELQKAATDTSCSFVTPEVLDLAEVDFDDYFI
TPPKSEEDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFG
DREGWPTEDDGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKKDYGERLSEWSEGVVDVLG
MLAKTGSLGEGLPGSGAPEESDDESAEEDDDEVLIEDSEAKPEKLKNRKNIDDVEDLGRI
MKSSNPEAEKNSRTAAAPIAVDFTTYGKTTQKKTPTAAAKEMVPKNSPTYASLTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYC
GTSTASNAGLSMSNVPFYWEVAEFVKALEKRLNEKGLRYGIAAEHAHSCCVLLASERFYV
DGKWHPRIDYQRFFELLEERGPDGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRK
IER
>A0A4Z1PS25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Venturia nashicola|TrEMBL
MDTPLDMWELLQDLLELWHDYRNPIILSTVAILTAMRIYLRFRAGREKLSESPLPGSPHS
PFNEKPEKLPIAVPMLREDHVEDFTSVEPKKLPRKTSPKRVTGKKLRTVAKDAAMFDCET
DAIQPLVFFSSLAGGTEKAAQEFVQNLSQWKSDADFAGIDRVLAPITHDLSYIEYDDYFI
NPPKDSKAKCFYIILLPTYNIDTVLDLFLEHLKETHNDFRIDTAPLSGLLGYSVFGFGDK
EGWPTEEVGFCSQAKEVDKWMAKLTGRKRAFPLGMGDVKKDSKERLEEWRLGVQEVIGDL
MSGKGLGEGVQGSGDAVESDEEDVEPESKSNLDDVEDLGRSYRNGQTTKAPLAVDFTTIG
KSKAPISTVKEMVPKDSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYG
IASHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEIIFEGVKAGHYKKIKMMK
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNAQHPEQLA
ALKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFIRCLDILKERRFEQRTVFRLTLVKG
FNIEDEAEGYADLVERALPCFIEVKGVTYCGTSTSSSAGLTMQNVPFYEEIQAFVIALNA
ALEKRGLAYGLAAEHAHSCCVLLASERFKIKGKWHTLIGYEKFFNRLESGKPFKPEDYVG
EPTPEWALWGNGGFDPRDERVDRKGRPKELDLGPRSVGRVVEI
>A0A507AKS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thyridium curvatum|TrEMBL
MADARRSWATGSFLQDATHVAIETWHAYRTPIILTTFFVLFGLLIYLHLTEERGQLLVLP
KIYEQDTKPQPEQQLDEKVVELPKATAASKTNGPRRIKGELNKPNKTIQIQEVSRSEEIQ
VLVFFSSITATTQKVASEYAQTLDKALSGIDTTSGASFLPIQVLDLAEVDLDEYFITPPK
IKGRNGSFVDTFYLFLIPSYNIDTINDTFLEHMNETHHDFRIDTAALAPILGYSVFGLGD
KEGWPTEDEGFCFQAKEIDKWMAKLTGRKRAYPLGVGDSKGDFKERLAEWSSGVVDVLSL
VSQTGSLGEGVVGSGDPIESDDEEEAEDDDGEVLFDEGSVPNMSKLKQQGRIDDLEDLGR
MIKKESGPAPVAVDFTSYGKRTAKKAPTQAPKEMVPKESPTYKSLTKQGYAIVGSHSGVK
ICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWVV
DPPELIFAGVKENHYKKIKVMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLA
MLHAERISSFLVCNAQHPDQLAALRHVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRC
LEVLRARRFRQRTVFRLTLVKGFNVEDEVAGYADLVEKALPCFVEIKGVTYCGTSTSAGA
GLTMGNVPFYHEVQEFVTALEAELQRRGLGYGLAAEHAHSCCVLIASERFRVDGRWHTVI
DYDKFFALLEERGPDGEFTPEEYMGPATPEWATWGNGGFDPRDTRVDRKGRAIEG
>A0A2T9X1H7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus hospitalis|TrEMBL
MVVSTLRIDTLSRIMEEMEKEKYHIIGNHSAYKKCHWTHEALTEGRYCYKGKFYGIESHR
CVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDETKLPITDDPEYIAEKSIEEHKRAVSGYL
GRKGVDPNMAKEAMKPAHVAISLTGEPTLYDRLGELIHEYHKRGLTTFLVTSGVRPDVLA
SLEEEPTQLFVSIQAPNERKHKLINRPIVANSWNLFLKTLEILPSFSSPTVIRMTMIKGF
NMSEEDAKDFAKLIEMAMPTYIEVKAYMHVGPSTLRLSRDAMPRHSEVREFAKLMEKYTG
YKIISEHVPSRIVLLSKLDKPIQIGNAWSDKWNWATKDTEDDIHGEYAEAELGSGNNQC
>C5WZ58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sorghum bicolor|TrEMBL
MTVARGPPGRPSSGLLGCWRRRPALGFGAKVGIAIALGLSFAIIWTSLSPTSSSQQISTE
RSSFAAEVAAPPTAFHNRTAGGGGGHAHRKPRPVPHSHKKRHPAPSGSHSHPHRSNATAS
LDAAAVKADHSEPAPVTDPGPKEKEPEQEQEQEQEPDMEMEPEQEAELPMPEQGGDNSGK
APAEEDEEKPPQLELEDEPSEDDGEEDDPEAAKRKAPSKKRKLPPLFSPGAHYHWKLCGA
KSSYHYIPCVDFDGDGSQRHHERSCPRSPVTCLVSLPKEYKQPAAWPERKDKVWYGNVGH
PRLSNYVKGHNWLNHSGEYLMFPPDEWEFKGSARHYVESIDEMAPDIDWGKNIRIILDVG
CKSAGFGIALLKKDVITLSLGLMNDQTDLAQVALERGIPATVGSLGSRRLPFPSGAFDAI
HCGDCNIPWHSNGGKLLLEINRILRPGGYFIISSKSADLESEEGISASMTALCWNAIAYN
SDDVSEAGVKIFQRPASNEVYDLRAKKDPPFCKEEQNKASAWYTHIKHCLHKAPVGIEER
GSDWPEEWPKRLESFPEWLGDTQTRVASDHNHWKAVVEKSYLDGLGIDWSNIRNVMDMRA
VFGGFAAALASKKVWVMNVVPVHAADTLPIIYERGLIGVYHDWCEPFSTYPRSYDLLHAD
HLFSRLKIRCKQPVSIVVEMDRILRPGGWAIIRDKLGILDPLETILKSLHWEIVMTFRKD
KEGIMSHLSARLTADAGFPVRASDAATFDPDDLPSVPLLLLVIPTHDGGAPPPSAAFLSR
WLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAAKSFSRWLRALGAVEVVPFGEG
DMDGGDLEAVFEEWSRRVLRVVKGEEVGYGANEKSNGLDELELEGEDWDDDDEEEMVDGE
VDMEDIAGKAPARRKNGNLEGVVANGVQNGVKDMVTPIIRTSLEKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDD
PLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVDEL
HRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLK
SLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLDLGQPDFIEIKGVTYCGSSATSKLTMENV
PWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELV
TSGKPFKSRDYMAMTPSWAVYGAEEGGFDPDQSRFKKERRHGTAAHKSLS
>A0A7L1BIX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Illadopsis cleaveri|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISIWIVIQFTTTRTKRKVGEVLLQDLGA
DKLGNGCVPPQAQEVHVAGVKIFYGSQTGTAKRFARTLAEAVTSLNLPVEVINMGDYDPE
DGLVEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRIDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLTQ
LQVLCKGEKKPCSGKCRKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKVLLLGGMECHFGYHLVYLVCQFLQTKLNYLMICALFSGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPI
MYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKDSLRRIDRPLF
KDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCG
ESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLLAHSKFQVDGEWRTW
IDYSRFQELVGEYERSGGCRTFTAAEYTARTPPWALFGARERGFDPSDVRFQRKNKARDI
SGC
>A0A023AYW3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gregarina niphandrodes|TrEMBL
MPRTILIYSSEWMGVRHKVLELAEATARKFKLDTGVKDENVRAYFNEVLLLETCCFSNIN
DWLYDSVAEGGANVFLFVATSEGGTIAPKCRAALEELRAFANDHRASPQERKSISFSVLG
FGDMAYGGTTFCRPAIEVNKLMKLSGARRVEHLVNVNASDSDATAGDVQKKIQWIDKCLS
RGIEDSLAADKSSEEDDDNSSDSDASCNSYDEGEGRDENKEMLGETQRRVLMKQGYRLVG
SHSAVKMCRWTKHQLRGQGGCYKHTFYGIQSHRCMEATCCLACANKCVFCWRHQKNPVAR
EWHWKADDPGHIVEQMLVEQRHMVQVFKGARGVEETGRLTEGLEVAHCALSLVGEPILYP
RINELLSRLHRESISTFLVNNGQFPEQLELLGTCTQLYVSVDASDPVTMKELDRPLHRDY
WERFLKSLSLLKNRIERTVYRLTIVKDRNEFDVQGYALLIPLGEPDFIELKGVTFTGKGC
GIRMTNVPTHQEVVEFGEMLVAELQNMGMDYELAVEHEHSCSVLVAKARYKVNGKWHTWI
DYPKFFTWFAALDLLTVGQKPDNLEYAAETPSWALLGAEEKGFDPADKRKYRKNRLLMME
EERKRKMTCDECSCS
>A0A5N6V0E2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus tamarii|TrEMBL
MAELSLTEGLVTFWHSYRLPILIAIASVAIILQVYRKFQPKSKAITASSIPPSPRSQTPE
KFEQTRTGETEKQAVAEKSVPKPASGNDPVPKVVSGPKRVSGKKPLKVAGRRREDQEPPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERANLENRETGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
NILVDILDNGGLGEGVPGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDE
QSGSGPVPVDFTTAGKSAAPSQSTVKEMVPKTSPTYSALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHNEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A3D8S2T7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coleophoma crateriformis|TrEMBL
MPQNTWVQELLWPIDRTDLVAVWHTYRIPIILSTFTILCIFRAYLHLSVPRNKVSFTPPP
SSPSLSSTKSTAPVKDVVEVRTVAEKSNAVQKAPRRIVGGLKKRKSSEEQLTTNDHQIQV
LIFFSTLTGTTERAAKTLGQELRNRTGRFLEPQVVDLAEVDYDDYFISPPKSETDVQYFY
LLMLPTFDIDTILDTFLEQLQETHNDFRIDTAPLSGLLGFSVFGFGDRDGWPTEETGFCS
QAKDVDRWMAKLTGRKRAYPLGMGDIKKDAAGRLSDWKQGVEDVLDLIAETGGLGEGVVG
SGDAVESDVEDEEEDDGEVVFDDENVALPKSKAKKDSVNDVEDLGKGLRTDASPSEAAEP
SDTFEVDFTTYSKKSKPPPAPPVIKEMVPKSSPTYTALTKQGYTVVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDAPDMIF
NGVKAGHYQKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPISYPYINEFTSMLHAEHI
SSFLVCNAQHPDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILRER
RFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEIKGVTYCGTSSSAGAGLTMQNV
PFYEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILIASDRFRVNGKWHTRIDYEAFFR
CLESGKPFTPEDYMGPETPEWATWGKGGFDPRDERVHRKGKNKKPLPESKVEELF
>A0A109UV33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp. YE315|TrEMBL
MSFNKNQIAKLEKSGYRFVGKHGHAAVKTCHWTRQSIVDKGVCYKEKFYGIQSHRCLQMS
PAVPNCQQECEFCWRDLTYTQTTWEDEEYDDPKTIVDEAIKAQNNLLCGFYGNSKANRKK
LEELKNPTNAAISLAGEPTLYPKIDELIGEFNRRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPSEKIFNNVCRPRIDNAWNNLNESLETLASFNSRTCIRNTCVRGKNMENPEGYA
KLIEKADPDFVEVKAYMCVGSSRERLTMDNMPLFDEVKEFAKKIGEGCGKEIVNESEISR
VVLLE
>A0A1A8WJX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium ovale curtisi|TrEMBL
MANGMMEEKRLEHYPPLRPFQMLSIRKKAKINFKVIYGSESGGTYKRAKEFLNELVEFFR
EIGSFFKDINRISLCGDNADGGSTNGCLIDTSELGSRLVAYFKSYLMEKEKNKAGLSRES
RGKRSRGRMTNGETQHLDIFKNGETESNEHFANCVDIFIENSISTVHIDFTSGNEFDSYS
FFENSQEYDLNILLLLLSTCNYGSFPKNCYKIEEILRDLLNDFRVGKNYLENVFYSCVGF
GNKQYGSKHFCAPIKECDKILTSLGAHKLYKTVKLCDEEDNVVTLLEWKSSLFKTLSLSL
FFYHFDFTKLRSNYVQYAMKKVYNSLKYYCSFFCEKDERDSNGHGEKVLSEVDVSFREES
DGAISPNVHVDENKKETIPTNATDEIDSKRRETFNCGSGDEVEDILFDTPKDMLSINQRE
KLTKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMETTPSLACANKCVF
CWRHHKNPVGTQWKWHKDDANMIVEEAIKKHRGMIKELKGVYGIIKERYDNAMNVKHCAL
SLVGEPIMYPDINQLIDELHKRNISTFLVTNAQFPSELKKLHKVTQLYISIDGPNRDALK
NIDRPLFKDFWERYIKCIKLLKKRKERTVFRFTLVKEYNMMSDEILSYAKLVEYGLPDFI
EIKAVTYCGSSEGYKLTMKNIPWHEEVYNFAHHLINCKSSITDAYDIACEHKHSCSILIA
KKIFKINNKWHTWINYENFQLLVKQGKDFTSTDYCAETPHWAVVGAQECGFNPSDKRVYT
KGRNKNRNPDETQRDSPVVVAPT
>A0A822DD14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ranitomeya imitator|TrEMBL
MDSLPSFIFKVTRSQEKSVPGAPDSSLSPQEKHTHVSGVKIFYGSQTGTAKGFAVVLAKA
VTSLDLPVAIINLKEYDPDDNLIGEITSKNVCAFLVATYTDGRPTESAEWFCKWLEEAAN
DFRFGKTYLKGLRYAVFGLGDSAYRSHFNKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQS
KHGSIEADFTAWKTKFISRLQALQRGEKKGCGGDCKRGKCESAQHGPGEVRSHPHGELHP
GDAEEEEPCESSSEDEHGTKGYQSLNSVVDVEDLGNIMNPVKREKREKAQPEEKVVVHRN
SEKNEDSEARAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHRNMIKQFKGV
PGLKAERFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQHGISTFLVTNAQFPEEIRNL
TPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLQALSAKQQRTVYRLTLVKCWNVD
ELQAYAELVSLGSPDFIEVKGVTYCGESAASSLTMANVPWHEEVVRFVRELVDLLPDYEI
ACEHEHSNCLLIGHKKFKIGGEWWTWIDYSRFQELVLQYEESGGSKTFSSKDYMARTPQW
ALFGARERGFDPKDTRYQRKNKTKDISGC
>A0A849QC57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanohaloarchaea archaeon|TrEMBL
MLPENIKAILEKQKYRIAGNHSAVKLCTWTKKSLRGEGVCYKEKFYGIKCHRCLQMTPAV
SWCPNRCIFCWRAIEKTLGPEMTGTVDAPETILEAAIAAQRNLLTGFKGFEGTDMKKWKE
AQDPNQIAISLSGEPTAYPLISDFIDMCNRKNMTTFLVTNGQFPDRLENMAKPYQMYLSV
DAPTKDMYKKMDAPIFKDYWERFTKTVDLMSSFTSRKAVRLTLVKGMNMSHIKEYAKIIE
KINPDFVEVKAYMNVGFSKYRLSRDAMPLHVEIKDFSEKLGKELSYNLTDESAPSRVVLL
ER
>A0A1J9PLW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emergomyces pasteurianus Ep9510|TrEMBL
MAGDELGIAAQGLLSLWHRYRVPILFLAPVVFAVVQLFPRNSKSHNTSQAPIPPSPNKKR
NQKAESDVLGAKSRTVVQPERNDSQPSSTDGGNARAKQHTNGPKRVHGTKPAKNGTKNQI
KGIAQELAIQPLVFYASLTGSTETYAKSFSDMLQKASQSLVENGEGTLLSPELHDLSYIE
LDDYFITAPKPPESAQNTKFFYCILIPTYNIDTMVNTFLGHLDETHNDFRIDTSALSGLA
GYSVFGFGDREGWPTEEEGFCSQAKEVDKWMAKLTGKKRAYPLGIVDVKGDDIQSSLSEW
CDGLRDVMRDLMASGGLGEGVPGSGDPVESDEEDIDDGDEENHETDQNRQKIGRRQQIVD
LEDIKFGASDKKKTSTDPQLLPIDFTTQSRAQNSKPAPQLEMVPTSSPTYTALTKQGYTI
VGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWKVDPPDLIFDGVKTGHYKKIRMLRGVPGVRAERFQEAMHIRHCALSLVGEPIFY
PHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKIDRPLHRD
FWERFQRCLDILREKRFLQRTVYRLTLVKGFNVDEEAAGYADLVEKGLPCFVEVKGVTFC
GTSTSASAGLTMQNVPFYEEVVTFVVALNAELARRGLGYGIAAEHKHSCCVLLASNRFHV
EGRWHTRIDYDKFFALLEREKNDGIPFRPEDYMNETEEWALWGNGGFDPKDTRIYTRGRN
KAKLNAALKESQENAASVEG
>A0A0L0H6C9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spizellomyces punctatus (strain DAOM BR117)|TrEMBL
MSFILSLLDVTSWSAPSWILVATLLFALWTVNRQTLSPSKVEKSRDQTPVNPTANGGQSK
IKSYSTRPKQRRAKKGDTSGEVTGGCCNVEEDEGCCSSNAGESCCKSSSKPATPTSETAI
PIENVPDREDTEEIDDEKRITLKILFATQTRTSRTLSYRLKELVEANVPLVKEVEVLNIA
DYENEDLMTEKSPVVFFLSTYTEGSPTEDAAWFYQWLEDTRFDHRVNKQCMKSLRFAVFG
LGDSVYEENYCTVAKRVDKWIGELAGRRICPLALGDKSDDTEHQFITWTKLFLSRINGVA
NHLSIAGEDNLDDFVEEGDYESSEEEEEEAATGSGDELMDLEDMGAMAAKIKSAKQQRTE
EEAALSSNKGGPKRRIGTKDAEERPEKLIKEMVTPMLRKSLEKQGYKIVGTHSGVKICRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRQHTNPVGTEWRWKMDDAV
DIVDGAMDNHYKMIKQLKGVPGVKPERFEEAFTIKHCALSLVGEPIMYPKINEYVDILHS
RNVSSFLVTNAQFPDAIENLKPVTQLYVSIDAGTKEDLKKIDRPLFRDYWERFLACLDAL
GKKGQRTVYRLTLVKDKNDSTLDSYVTLISRGNPDFIEVKGVTYCGFSGASHLTMKNVPY
HHEVLTFCKDLCERLGGKYEVACVHEHSCSVLIADKARYYKDGGWWTWIDYNRFFELIRE
GKPFTSEDYMERTPDWGVVGDERGGFDPEETRFYRKGRIPAGEEGQR
>V5HHX2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ixodes ricinus|TrEMBL
LLGQVKSKGLCIFIVSTYVDGGPPDEAVWFYDWLKDTYADFRVHKYFLQGLDYAIYGLGD
SAFNDNYNKVARDIDFWLSKLHARRVVPLCLNDESVDEGKYGTGKFGAWKSELLAQLRLG
AKGAAQFDAPEEKPTAYETSSDEEGGGDLIDLEDLGTVRIASKNKAKAEGAAGQPKDMLT
PPVRESLTKQGYKLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIDSHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWKWNMDPPEMILDAALESHYKMIKEFKGVPGVLRERLAEGLAV
RHCALSLVGEPIMYPEIGRLVRLLHARRVSTFLVTNAQFPEALEALGPVTQLYVSVDASS
QEALKRIDRPLFPDFWQRFQDSLTALARKGQRTVYRLTLVKEWNMAEMQGYANLVELGKP
DFIEVKGVTFCGESKGSSLTMGNIPWHEEVLSFVERLAALLPDYSIASEHEHSNCVLLAH
HKFRMDGVWHTWIDYEKFHELVQRHYESGEPFGSLDYAAPLPPWATFGARERGFDPNDTR
MLRRSRKDVGGC
>B5VSX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain AWRI1631)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
T
>A0A5F5PG58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Equus caballus|TrEMBL
MDPSLDTWDFSPLISLWIHRFYIYWGFAFGISLWICFQIVIRKQDKTSQEKSLSKATRDL
VTNGYISLQEKEVFVSGVKIFYGSQTGTAKGFATILAEAVTCLGLPVAIINLKEYDPDDH
LVEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEASIDFRFGQTYLKGMRYAVFGLGN
SAYASHFNKIGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGSIEGDFRAWKTKFISRLR
ALSKGEKKSCGGNCKKGRCKSSQHGSEEMEPGSPAQDGLHQRDTEEEEPFASTSEEESSI
EDHQSLSSVVDVEDLGKIMNHVKKEKREKEQQEEKTSLFRNTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIKNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVHELVDLIPNYEIACEHEHSNCLLIAHKKVRI
TQIVILLSSLSLLLFSSLFSLFSPQPSYSEYLLVCYLF
>A0A2A5VKM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group II euryarchaeote MED-G35|TrEMBL
MEPRIASRLSKQRYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLESVRGHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRICKPKFDQGAFHKLEQTLEILPSLDTRTVCRHTLIKHESLGHHDDYARLDNIA
DPDFIEAKGFVFVGNSRNNLSIDNMPSHPEVMEFSEKLAPMVGREVLSERRESRVALIGR
EMIPITLPEKTMELPADLGIARPQNFSLPQA
>A0A851ZLK5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halcyon senegalensis|TrEMBL
LDVSMDTWNFFYTSLVSLWLHRFYIYSAVAFGISIWVVIQFTTTKTKKKVTEHGNPAAPE
GTEDKLVNGYITPQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVASLNLPVEVISMGDY
DPDDCLSEETTSRTVCVFLVATYTEGQPTESAVWFCKWLEEAANDFRYGRTHLKGLRYAV
FGLGNSVYVDHYNTVGRNVDRWLWLLGASRIMTRAEGDCNVARSKHGSIEADFEAWKATF
LSRLQMLCRGEKKPCSGKCRKGKCKSPGKQSKESSDHERGASEHENAEAEELFETSSEEE
ADAEEAGGTNSVVDVEDLGNIMSHMKKAKQSLAWTAVLEGGGMQHPFQHSSRNPVRTQIL
AAQGGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALS
LVGEPIMYPEINRFVRLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDDLKAYADLISLGKPDFIEVK
GVTYCGESSASNLTMANIPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKIN
GEWCTWINYDRFQELVREHEGSGGSKTFTAADYAARTPRWALFGSRERGFDPLDVRYQRK
NKTRDLSGC
>A0A015IIR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis (strain DAOM 197198w)|TrEMBL
MLLRYFESLYLSYQALFWSCLAVGGIVVFYVTLLNSKKKKKQIIEDNKKIRELSAVNKEK
TTGKGLRKRFTRSTKKTSNQTCTNDSGEKSACCGNGGVSDCCKNQLSEETYHIITANKST
KISVKIFYATQTRTAKYFAQQLYQSFTKHSNCECSIMDIVEYETEDFLSESAICIFLIST
YNVEGPLDWFYKWLEDTRYDFRVDKQALSKMKFAIFGLGDSAYGDQFCIQPRNIDKWLGQ
LGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDPSYALNNVSSNLNYDSYSESDSDSD
NNNNSDTEMVDVEDIGALAPKLQAARKSKEEEEFVYKNSNGRPKRTLSEQEVPINEPKEM
VTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSHRCLETTPSLA
CSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLSNHYKMINEMKGIPGIRADRFQEAF
NVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMVCNAQHPSRLRALDKVTQLYVSVDA
STKESLKKIDRPLFKDFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEIANYVELVRRG
KPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFVKHLNENLGDTYEIATEHSHSCSIL
IANTKFKINNKWYTWIDYDKFFELLEKGEHFTSLDYIAPTPSWALFGSPEAGFNPEDQRF
YRKSKKNNNSVKNGGC
>A0A8C2RQT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capra hircus|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTAPKASQD
LMMNGYIFRPKKEVFVSGVKIFYGSQTGTAKVTSKNVCAFLVATYTDGQPPESAKWFCKW
LEEAANDFRFGKTYLKGMRYAVFGLGNSVYVSHFNKVGKNVDKWLWMLGAHRVMTRGEGD
GNVVKSKHGSIEADFTAWKAKFISRLQALCKGERKRCRGNCKKGKCESNQRGSEAAEPGS
HTQEELHHGDAEEEEPFGSTSEEESDTEDHQSQNSVIDVEDLGKIMDHVKKEKREKEPQE
GETSVIRSTVKSEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCY
KHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQN
MIKQFKGVPGVKEERFEEGMTIKHCALSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQ
FPAEIRDLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLT
LVKAWNVDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRTVYRLTLVKAWNVDDLQ
AYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACE
HEHSNCLLIAHKKFKIGGEWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALF
GANERGFXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTQTDGCRRFSDSTVIFFPRTGYTN
NISHREGREEEHGATSHVPGLRREQPHWSAWDLA
>A0A498H481|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus taiwanensis|TrEMBL
MQSEACNALRKQGYQFFNPRSSAAVKPCLWNKRTLKGGEMCYKAQFYGIESHRCVQMTPT
LRCNQRCLFCWRSFEHEVTEEEECPPAEIRENLWRLQKKALSGYKVSQYVTGERFREALA
PTMVAISLSGEPTCYSPLPELIDGLNEDGYTTFLVSNGTRPDVLARCRPYQLYVSLDAPD
RETYLRLCRPREDYWDEIGESLALLAARRSAIRVTVVRGLNDFAPEQYAARIQDSGATFV
EVKGYMHLGYSRHRLKRDHMPAHDQVRAFAERVAEHCDYRIKDESPISRVVCLERIA
>A0A0E3PI52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina siciliae HI350|TrEMBL
MPLEERKEEKKDSGESFPEIPEENRGEEQASLPFDIPDFATLLKKQSYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLICNHRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIDCQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDIMK
EKCSRTVIRTTLVKGENIFSPEGYAELIKKASPDFVEIKAYMHLGFSRLRLDRSAMPAHA
EVLEFSKELAKHLGYDIADESEISRVVLLSKDGKKSPVRKVSFKD
>A0A7R9N013|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedenaceae archaeon GB50|TrEMBL
MADEIQKLLKKHGYQRAGRHSAVKTCLWLKRSINNMGQCYKSRFYGIASHRCIQMTPTLQ
CNQRCLHCWRAIDAAIPETPWDSPEVIVNETLRAQERLVSGYGGSARAERSLWEESKKPR
HVAISLAGEPTLYPSIGELVNAFHRKGLTTFVVSNGTRPEAIDEINPTQLYLSLTAPDSE
TYLRVCRPEREEMWEDLLESLEILSEKRRRTAIRVTLIEGVNDRDPGGYASLINRATPDY
IEIKAYMHLGFSRKRLERGAMPTHSKIKRFAQKIIEYTGYRLVDESEPSRVTLLSRDGKN
EKIEREDAN
>W0JNV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halostagnicola larsenii XH-48|TrEMBL
MSDSDETLQVSDPDYHSENHTAAQTCGWTANALRGEGKCYKNIYYGIESHRCIQMTPVVR
CNERCVFCWRDHAGHAYELDGVEWDDPEAVVDASITLQKKLLSGFGGNEKVPDEVFEQAM
EPRHVAISLDGEPSLYPYLPELIEAFHDRDITTFLVSNGTRPEVIRECDPTQLYISVDAP
ERHTFDQVVKAMEEDAWEKLLETMDVLAEKDETRTVLRTTLINGENMHSPDLYAAYYQRA
DPDFIELKAYMHVGHSRGRLDRESMPDHEEVVAFAEDVKEHMPEFTECKGVPASNVALLS
KTKDTWVPKLKKDSEFWADDPLASD
>A0A8C0JXM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus dingo|TrEMBL
LDPFSDTWDFSSPVISLWINRFYIYLGFAFGISLWICFQIVIRKQGFATSLAEAVTSLDL
PVAVINLKEYDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIE
ADFRVWKTKFLARLQALQKGEKKPCDGNCKRGQCESSVVWSFCVRASHESSFLHLGLAEE
EPSESTSEEESGTEDHQNLNSVVDVEDLGKIMNCVKKEKREKEEQEEKSSLVRNTVKNED
SERRTMITPALREALTKQGENPQEVLSQYYPLNPGSNPTSGSRCMEPAPPSACSLEFLPL
VLRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKI
GREWWTWIDYNRFQELVQGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A2K5ZTT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mandrillus leucophaeus|TrEMBL
LDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKTQDRNLQEKSVPKAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVTIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPPIGEMLRESIVDASTKESLKKID
RPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFIEVKGV
TYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKFKIGGE
WWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQRKNK
SKAISGC
>A0A5G2R9F4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKCAG
LLFSLSV
>A0A497LYC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKTENEQLLVPEELLKTLRRQRYHLVGRHSAVKRCRWLYESLINDRVCYKQKFYGIRSHQ
CIQMSPTAFYCTMRCLFCWRAQSGDLGIKWEELKLPEKWDSPEEIVEGCIKAQLEILSGY
KGNPKTNMKKYAEALHPKHVAISLIGEPTLYEPLGELIHEFHKRGFTTFLVSNGTLPEAL
SKLSEEPTQLYISLYGPDEKTFKKISRPQIPKAWERINQTLEMLNSFKCPTVIRITLVRN
LNMKNPELYAKLIEKANSTYVEPKAYMHVGFSRLRLKYENMPTHGEIRNFAEELAKETGY
KIIDESVESRVILLSRLEKPIKFS
>A0A7J4NWY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSSLVSVPEELRSRYVRQRYRLVGAHSAVKTCTWVGKALRTSGAEYCYKQRFYGVPTHRC
LQMTPSLGHCTQSCIFCWRATPETLGVGWEQTQPIRGGDDPDAIVEGAIAAHRKLIYGWG
GNERVTEQYLKEALEPVHAAISLEGEPTLYDRLGDLVASFKAHGFRSVFIVTNGTKPEAL
ANLGSEPSQLYVSLCAPDEETYEKTCRPMIPGAWERVRETLELLHSFRCPTVIRQTLVPK
LNMNNIKGYAKLAIKAEPTYIEPKGAMSVGFARQRFAYEDMANFEDIKAFAVKLSEETGY
AAIDEQYESNIVLLSRLKRPINLYA
>A0A2S2KT26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus zosterae|TrEMBL
MSCSGEIIEEDDRLIQIKPAISEQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLESTKSIFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADYESFIRINKPKYDDSWERWNRTLNMLKDLNTRTVL
RVTLIRNYNDQKESIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMEEVKKFS
EEIAKQSRVFSVMDESIISRISILQNNERYIDRFIPTYSNTN
>A0A257ARJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon ex4484_121|TrEMBL
MAIAYGSTRLKLDEINRLRKAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGVESHRC
LQMTPSLQYCNMMCVFCWRHHTINRIKPYGGEWDSPKEILDGLIEEQRQLLSGFKGNPKV
DPRLYNEAMEPNNAAISLDGEPTLYPFLGELIKVFHERGMTTFLVTNGTMPEMLKILPDV
GAEPTNLYISLYGPDRRTHVRTCRPLINDSWERLIDSLRIMNMFTESRRVIRLTLVKGYT
MRDPERYAELIRIADPDFIECKGYMHVGESQKRLPRSAMPSVMEVEKFAKSLQAHLKGYD
YIAKDVPSRVCLLAKKTSPHYDKALKNAERMGELIQNTS
>A0A7J3ZNF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MENALIHSLTPEVMSLYYKQGYRLVGKHLHSAVKICQWTKESLRSNRVCYKELWYPPVQS
HRCMQMTPYLGCNCHCLYCWRLHSGDREGLVWKEFPLDLKEFDEPSEIIDELIEKRKELL
SGWKGNPKVDKKKFEEALKPTMMTMSLTGEPTLYPRISELVVEASKRGMITFLVTNGTLP
EVLERMSPLPFQLYISVPAPDKSTYIKIVRPLIRDAWERLNRTLDLLPSLETRRVLRFTV
IKGWNTMNIEGYAKIVERAKPDFIEVKAYEWVGQSRERLPREAMPYMEDIEEFSVKLANL
TGYEIKGKYKPSGAILLS
>D0MY43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora infestans (strain T30-4)|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLQTHPRTLPGSDAVVTSPKRKAKKKPQQTAKTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGEPPEDAKMFCNWITDMTQDFRVSKNWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKSSSPVKAD
KDGKKWLSQKEFRRQKRAKKAQENGDKVELNEEDMMNEQFLVDEFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHSHSNCVLIAKKKFCREGVWHTWIDYERFHELIAKYYEDGTPFT
ADDYTAPTPYWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A4Q4Z0X3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. CRB-9-2|TrEMBL
MSATFWESVADGNRALTAVLFTVWLYLRLSQRQTKGAGSPKLESGKSLPAELLAEEKVSL
STAKESSSGPRRIKGELRKADGPKSAMQLDPQRRVQVLVFFSSLTGSTERTAKQFTATLE
ASLLDQTSGSDQAFLKPQLLDLTQVDYDEFFISPPKSAAASQPIDYFYLILLPSYNIDTI
NDNLLEHLKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQAKEVDKWMAKL
TGRKRAYPLGMGDSKRDLKERLAEWTEGVTEVVRQIAKTGCLGDGVPGSGDAVESDDEYV
SGEDDDGEVLVDEPVQPKKTKNSTRDIDDVEDLGRIMKTSRADANDATARAPIAVDFTTY
SKTSKKPPPTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKM
MRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHSERISSFLVCNAQHPEQ
LAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDILRERRFRQRTVFRLTLV
KGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSGGKDGGLSMANVPFYAEVTAFVE
ALDRRLRERGLGYGIAAEHAHSCCVLLASERFRVDGRWHTRIDYDRFFELLEERGPDGEW
TPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A2T8I0H1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panicum hallii|TrEMBL
MPPSPTATTASATSHLALLFLLSSSSLFFFYKSIRLRRKPSPATATATGPARTTIPTLLY
ASATGTSKTLAARLSARLTADVGVPVNATDATSFDPDDLPSVPLLLLLVPTHDGGAPPPS
AAFLARWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVEV
VPLGEGDVDGGDLEAVFEEWSGTVLRVVKGEELNEGVEGESDGLDELELEGEESDVDDEE
EAVSGEIDMEDIAGKAPTRMQNGKVEGGLTNGGQNGVKEMVTPIIRTSLEKQGYKILGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
KWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEIN
ALVDELHRRHISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAVDRPLFSDFWER
FLDSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSK
LTMENVPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYD
RFHELVISGEPFKSQDYMAVTPSWAVYGAEEGGFDPDQSRFKKERRHGTAALKG
>A0A0W4ZVU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pneumocystis jirovecii (strain RU7)|TrEMBL
MSFMSLLLLLYELWRYFPQTFLRTKKLQFKSNILEKNDILCSKETKNDTDDQVLKYEKIK
TLKRFIISPERRRKITSSLKYESMKAFENNTQGMTDIVIDVYVTILYQTLMGSTEKYAKL
LYDMIFPYFEKQVSLENIDFVEDLDDYFVSPKNSQSHIFILVIPSYETDSPVDMLISMLK
DTLHDFRLGAFPLRDLKGYAVLGLGDQENWPQQKFCYQAKEIDRYLSKLGARRIVPICCG
DVKGNIVNDIQVWANKVVNVIKNRTIPELISDISEESDNDAFEDNQDSVVDMEDIGMLMK
VKKNDSEELTIKEMVAKDSPTYKALVKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGIKSHLCMEITPSLACANKCVFCWRGHTNPVGTSWRWKTDKPEDILAGVMAGHHDKIKQ
MKGIPGIQLQRLQEAMRIRHCALSLVGEPITYPYINELIKMLHDRKISTFLVTNAQHPDA
LENIEQVTQLYVSIDASTKDSLKKIDRPLFKDFWERFLSCLEILGRKQLRTVYRLTLVKQ
FNTQEIEEYANLVFIAKPCFIEVKGVTYCGNTDSSPLTMQNVPFHEEVVNFSKALTQKIS
EIDNMPEYRIATEHVHSCCVLIAQKRFYINDKWYTHINYDRFFELVESKMPFSVMDYISE
TPSWAYFNSVHGGFNPEDTRWRRKGAKPIDLKKDME
>A0A519CHQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPVLMAKLQKQRYHIVGEHGGVKICHWTKESLLRGRQCYKGKFYGISSHNCLQMSPVVD
QCNLACSYCWREPHMDALELSDQDPLEMLYDSVKAQRRLLSGFGGNDKVPKDKLLSAQTP
KHVAISLNGEPTLYTKLSEYMELCHAHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKQVFDEICRPKWNAGAWEKLEETIDLLPSLDTRIVCRHTLIKGRNMKEEHIPQYAALDN
RADPDFIECKGYVHVGNSRDNLTAENMPWHEDILEFSNALAPLVNRELLDDSPPSRVSLI
GKEIVPIPIPEPTMFFPDDLGIAASVKHLKVV
>A0A7C4XST6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MENKYASVYRKQHYGLVGKHSAVKVCHWTKKELSGEEGCYKGTFYGIRSHQCVQMTPALN
SCTENCTFCWRFQGFDSMHISDEDDPELILEESIKAHRKLISGFKGNAKVTKEKWDEAEN
PKHIAISLTGEPTLYSRLGEFIALAKKRGMTTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKQIFNDVLNPALGNAWENFNRTLELLPSLDTRIVLRHTLVKDVNMPYLDEYAALDTKA
DPDFIECKGYVHVGQSITKLTIDNMPSHDSILEFSNALAGKIGYQFTADRRDSRVALISK
DPSTAKIDFDEIFKSRDKEMISVA
>A0A2E7T1G6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAGLDN
RANPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A256Z7Z9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcales archaeon ex4484_42|TrEMBL
MLKGGVRGEVLRDPLTLIINRLKNQKYHLIGTHSAVKKCLWVHNALVEGRFCYKCKFYGI
ESHRCIQFTPSTLWCWNACLHCWRVRPQDYGFSYSDLTRLPYVDDPDFIAEIAIHEHRRT
VSGYRHRTSEKLWREAMDPKHVAISLTGEATLYPRLGELIKAFHKRGLTTFLVTRGIRPE
VLASLDEEPTQLYVSIEAWNREMYDYFNKPLTSRGWDRTLETLEILPSFTCPTVIRVTVL
RGFNMDERAVSGFSKILSIAEPTYIEVKAYMYVGGSIERLSRDNMPSFKEVLEFAKKLSE
SMSYRVASYSIPSRVVLLTKLEKSIIRYGKGCPKGWYEEEVGDEYSGEYGKIEDSI
>A0A2E7GZQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPMDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDAVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDEHIQQFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARTVLSDSRPSRVALV
GTSITPIPVPEPTLFFPEDLGIAPSVKHLPVVS
>A0A2E0KR24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPLEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRSLAPLTDRKLLDDSPPSRVALI
GKEIVPIPIPEATMYFPDDLGIAESVKHLKIVQ
>A0A2E4BI67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPIDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDQVCRPKWNSGAWGQFEKTIDLMPSLDTRIVCRHTLMKGVNMSDAHIKEFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARKVLSDSRPSRVALV
GTEITPIPIPEPMMFFPEDLGIAPPVKHLPVLS
>A0A2D5WV85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLAKQRYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMXMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVXAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGHHEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSQXLAPLVDREVLSERRESRVALIGR
EMIPVKLPEKIRDLPKDLGIAKPQNLSLPTL
>A0A091GH75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuculus canorus|TrEMBL
LDVSMDPWSFFYTCLVSALLHRFYIYAAIAFGVSVWIVIQFLSTRKKGENSNRNPAPSEG
IEGKLLNGFTTPQAKEVHVAGVKIFYGSQTGTAKRFATGLAEAVVSLTLPVEVISMGDYD
PDDCLAEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRVMTRGEGDCNVAQSRHGSIEADFEAWKAKFL
SQLQALCRGEKSCSGKCKKGKCKSLGKQSKESSDHEHWASEHENTEAEELFETSSEEEAD
AEEAGGANSVIDVEDLGNMMSHMKKAKRERELEEGDVGMSLTGGNAGRKEEGEKREMITP
ALREALTKQGYKLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHRNMITRFKGVPGVKANRFEEAMTAK
HCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTK
ESLKRIDRPLFKDFWQRFLESLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPD
FIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLVAHK
KVRL
>A0A534L437|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDSQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLACQFCWRTQEWGSDSLLLADDPGLIVEDSIRAQRELLSGFKGNPNVTRERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDEFKRRSMSTFLVTNGTTPATLRRMHAEGRLPTQLYVT
VAAPNEEIYQRLMVPKSGNEWRKLRETLALLPSLPTRTVIRHTLVEGWNLGWEDEYADLD
RIAKPMFIECKGYSFVGESRLRLEAENVPSHASIRTFAERLANRIGYRVAAEREDSRVVL
LTADGELHPLSR
>A0A2D8AQG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYXIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPLEMLYESVRAQRRLISGFGGNPKVPQEKFLDAQNP
KXVAISLNGEPTLYTRLSEYMELCHSHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKQVFDQICRPKWNSAAWDXFEXTIDLLPSLDTRIVCRHTLIKGRNMNXEHIPQYAALDN
RADPXWIECKGYVHVGNSRENLTAENMPFHEDILEFSKALAPLTDRKLLDDSPPSRVALV
GKKIVPIPIPNATMKFPENLGIAESVKHLKIIQ
>A0A522VA52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedens sp|TrEMBL
MTSISSPTQDILKKHGYHLAGSHSAVKTCLWLNKSMRNDGDCYKSKFYGMTSHRCIQMTP
TLVCNHRCLHCWRAVEVPVALPDQWDSPIDIVKSCLIEQRRLVSGYGGSEFMDRTKWKEA
FEPRHVAISLSGEPTLYPYLPEMIEEFHNKGMTTFVVTNGTNPEMIGSLKPTQLYISLNA
PDKETYQKVCAPLAETWDNIRQSLEIMNGYETRTAVRITLTKGVNMDAPEGYARLIGLAE
PDYVELKAYMHLGFSRNRLSRDNMPSHQEVLDFSKKVAQALGYGVADSSESSRVVLLSKD
GKKTDIV
>A0A8C4ETJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
SVWSLYFESTYRKLPHALTESYLMSVWSNRLYLYSAAALVFGIWLSLKMALKKVNCPLLM
SHLHSSVKKDDRDAVVHVSGVKIFYGSQTGTAKAFAKELSEEVKASGIPAEVIDMKDYDP
DDQLADECTNKAVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFG
LGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLN
RLQALAKGEKKTCSGNCKTGGSCKNKRKEGHEQEEEEEEEEDLMESSSDEEESGLQDEKK
SGSVVDMEDLGNIMSSVKKAKVRLYNDQLSKMNGLKKTEDEGERREMITPALREALTKQG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDPAETILQDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEP
IMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPL
FKDFWPRFLDSLRALGEKRQRTVYRLTLVKSWNVEEMQAYSELIALGQPDFVEVKGVTYC
GESSASSLTMANVPWHQEVVAFVQQLTDMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWT
WIDYERFQELVQAHEESGGQQSFSALDYIAKTPSWALFGAHEQGFDPADTRFQRRNKTKD
ISGC
>A0A7K4CDT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MPSSPCDALRRQGYQFFSPSSTAALKPCMWCKRALQGGEMCYKHQFYGIDSHRCVQLTPT
LLCNQRCLFCWRSFEHEPQEEEECPPEIILAGIHKYQKKALAGYNAVLDNTVTKTMWEEA
LDPRHIAISLSGEPTLYSRLPELIDLANKTGYTTFLVSNGTNPEMLMRCNPFQMYVSLDA
PDRETYHAVCRPQGDYWDRIHESLSLLGSRRSAVRITLVKGLNDFHPERYAAILQESGAR
FVEIKGYMYLGYSRNRLARENMPEHAAVRAFAEKVAAACDYRFMDENKLSRVVVLERIS
>A0A667YLC7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
LLAVQCSNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLRGLRYAVFGLG
NSVYVGHYNTVGKDVDKWLWMLSGMRILTRGEGDCNVTKSRNGSVQADFQAWKVKFLSRL
QDLAKGEKKSSTGSCKSGSGSCKSRTKRSQGQSEEEKAALHDNFEAELVESSSDEEESAL
PEESQSGSVVDVEDLGRIMNSVRKAKVSLQPTTHLTLMLFFYLCYHSSLQKRKILPRLFS
MLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKIL
QDALEKHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRI
SSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEK
RQRTVYRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQE
VVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSG
GQRSFSALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A8J4PDF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aptenodytes patagonicus|TrEMBL
LDVSMDTWNNFYACLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKSNGN
PASSEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
SMGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFDA
WRAKFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFET
SSEEEADAEEAGGTNSVIDVEDLGDIMSHMKKAKVLLLHCLINFFYLFSGYKLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINRFV
KLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLD
SLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASNLTM
ANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKINGEWCTWINYDRFQEL
VQEHERSGGSKTFTAADYAARTPLWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A1Z5JDG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fistulifera solaris|TrEMBL
MSQASSRNQSVAVAVALLGGGITIAWYSSRYLWPTTERTLESVSSSSSSSSSSSSSSSSS
SPDVPIQEVECSQRQPTKEESKLLRILSPGTISIVHASITGTCEKLAEQLYSELSALVTN
RVVQVGSVQEWDWWDELLNEDDEGDVKDDEGDVKHNKVPLPVLILLLPTHTNGTWPPFAA
DTLERTLQDVQHDWRVQSLFLKNKLQVAIFGMGSSEYDDTMGRPARECVRHFQKLGAKCL
LRLRVGDDAVGDHAKETFHQWNMELQRKLKVGKKEESDTSSKDCACGAEAKPNGGCHQHA
KEPFEVEDEHADYESDEEDEEDAEEPTVMDLEDMGNAMASEKKQEGNGEPREMVTPRQAE
QLKKEGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVF
CWRHHKNPVGKEWRWKTDDPQFIVEQAVQTHVNMIKVTKGIPGVQMDRWQEAHTVRHCAL
SLVGEPIMYPRINEFLSELHHRDISTFLVTNGQHPHAIESLLPITQLYVSVDAPTKESLI
AIDRPLFQDAWDRLKQSLVSLKNKGQRTVARLTVVKGWNSDEVSGYAKLIALGHVSLVEI
KGVTFCGKSDASNLNMSNSPWHHEVVDLAKTLRAELNRIRETDCAVPQYDLACEHKHSCS
VLLARVDQFLEISSEGKRQWHTWINYPKFQELAARHEADPSFTFHVKDYTAPTPKWALFG
AEEEGFDPTDTRHRKATKQPKYTQYDDRGIPTHDHTGQPLAEEERQRLFQLMEARMREIG
TGSTVTELRGGAKEIQDASLMFRGLVVSI
>A0A4E0Q568|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus halotolerans|TrEMBL
MSRRKQKVHDITDFKSLLKKQGYSLAGKHSAVKTCLWLGRAIKNEGECYKSAFYSIQSHR
CLQMTPTLMCNQKCLHCWRPTEIDVPMPGDWNSPVEIVGSCIESQRKLISGFGDSAPRDL
WMEGNEPRHVAISLSGEPTLFPHLPELIEEFKEQGFTTFVVSNGTVPAMMAKIDPSQLYM
SLDAPDLQTYEKVCAPKSPELWDRINESLAILKNKDTRTVIRITLIKGVNMFDPEGYAEL
IRKAEPDYIEVKAYMHLGFSRKRLPREAMPSHEEVLDFSGKIAENLGYRIADDVAVSRVV
LLSKDGSVSPLV
>A0A7K4JEV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geococcyx californianus|TrEMBL
LDVSMDMWSFFYACLVSAWLHRFYIYSAVAFGVSIWIVIQFFGEKSSRKPASSEGIEGKL
VNGCATLPAKEVHVAGVKIFYGSQTGTAKRFATGLAEAVISLTLHVEVINMGGYDPDDCL
AEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWLWMLGASRIMSRAEGDCNVAQSKHGSIEADFEAWEVEFLSRLQA
LCRGEKKSCSGKCKKGKCKSLGKQSKESSDHEHETSEHENTEAEELFETSSEEEADAEQA
NSVVDVEDLGNIMSHMKKAKVLLLQRSMYFMYQLLQGKINGLNYSLFSGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKM
DQPEMILQEALQNHHNMIKEFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINRFVK
LLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDS
LKALSEK
>U2YX46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halarchaeum acidiphilum MH1-52-1|TrEMBL
MPEQVDSPSYHHENHTAAQTCGWTANALRGEGTCYKHAWYGIRSHRCIQMTPVVRCNERC
VFCWRDHNGHAYELDGVEWDDPEAVVDASIELQKKLLSGFGGNENVPRERFEEAMDPKHV
AISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEVLEHCDPTQLYVSVDAPERATF
DDVVGATEDDAWESLIDTLDVLHAKDETRTVLRTTLVAGENMANPDWYAGLYRRADPDFV
ELKAYMHVGHSRGRLDRDSMPSPETVAAFAERVGEHMPDHPVVKTQEASSVALLARDEET
WVPELAPGGGFYD
>A0A7L2XBE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erpornis zantholeuca|TrEMBL
LDVSMDTWSHFHTCLLSIWLHRFYIYSAVAFGISLWIVVQLTTTRTKRKGEKSLGDPASS
EGTADKLGNGCAPPQAQEVHVAGVKVFYGSQTGTAKRFAKALAEAVSSLNLPVEVINMGD
YDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYA
VFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKAK
FLTRLQALCKGEKKACSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEE
EAGGTDSVVDVEDLGNIMGHMKKAKREQELEEGAAGIWKKEEAERREMITPALREALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPELILQEALENHQNMIKQFRGVSGVKAARLEEALAVKHCALSLVGE
PIMYPHINRLLRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELRAYADLISLGKPDFIEVKGVTY
CGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCVLLAHTKFQVDGEWR
TWIDYGRFQELLREHERSGGCRTFTATEYSARTPPWALFGARERGFDPRDVRFQRRNKAR
DISGC
>A2XMF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza sativa subsp. indica|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A7D5TFK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halosimplex pelagicum|TrEMBL
MSESDGPKQVSDPEYHSENHTAAQTCGWTANSLRGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADASLELQKKLLSGFGGNDQVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFRDRDITTFLVSNGTKPEVLAECDPTQLYVSVDAP
DRWTFDETVKAVEDDAWERLIDTLDVLAQKDETRTVLRTTLVDGNNMHHPEWYASMFQRA
DPDFIELKAYMHVGHSRGRLDRDSMPDHEDVRAFTEDVMEHMPEHDYLNDVPVSHVTLLS
KTEDTWVPKLQKDSEFWERDPHAEAGD
>A0A7G9Z1U5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-1 ERB7|TrEMBL
MEPKAILNYHEATLEKQGYHFVAPHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAHRCV
QMTPCIFCNQRCIHCWRPLEAFNMGEVDIAWDTPLEIVEGCMKEQRRLISGFKGSSKTSK
AAFAEAEEPKHAAISLIGEPTLYPHLQELIQEFHSHGMTTFVVTNGTNPAVLREIHPSQL
YISLNAPDETIYKRVAHADYWAQIQESLEVMKRMKERTVIRITAMAGTNMVDPGGYAKLL
ETANPDFVEVKAYMHIGYSRKRLSRAVMPSHTEVKEFAGEIAEHLTSSGYDYKIVDESEI
SRVVLISNLSSEVKALPKL
>A0A4V2JWQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hamiltosporidium tvaerminnensis|TrEMBL
MSVNIFYATETNKSLKYAIKLSNALISKNIDVGVHSFDDYFYSEIALFITSTFYDGQVPK
NGRVFFKKLKIAAKNNDLEFKPPKFFAIFGLGSTAYLSLFNLVAKQIYGYLITLNSISML
SPVYSDEYGDMEAVFDNWVSNVCDSLTNNNYQTNQNPKSSEIIDTNNKPDVSDIEDLSLM
LTPSLSKNLKKQGYSLVGTHSAVKLCRWTKSMLKGRGGCYKNTFYGIISSSCMEATPNLA
CANKCVFCWRHYTNPVGTKWRWNADEPDKILKGMLEEQNKLINSVINGVKTEINKFKGVK
HCALSLVGEPVMYVHINKLIELFHKEKISTFLVTNGQFPDQMRALKDVTQLYLSIDAGDP
VSLREIGRPLFTDYWERLLECIDILKEKRGRTVFRLTLVKGINDETTDSNKEEQERNENI
LGGYISLIKRGTPDFVEIKGVTFCGWTQDSGLSMKNVPYHNDVINFAIQLINGLEGYEIA
CEHEHSCCILIANTKYKKNQKWYTWIDFDKFNEDLQGIEYSCETPDWALFGSREKGFNPN
ETRYQRKKNQIK
>A0A2I0N823|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon HGW-Thermoplasmata-1|TrEMBL
MPLNPDLVKILQKQHYALVGEHTGVKLCHWMRQSLLHGRQCYKADFYGITTHRCLQMTPT
INHCNHKCLYCWRYQGFNQMGFGEGDAVDDPAFILDESIKAQFKLLTGFKGDPRCEEAKW
NEAIAPRHVACSLSGEPTLYPRLSEFFEECHKRGMTTFLVTNGTTPEALAKMDTLPRQLY
VSVDAPSEEIYKNLCAPLISKGWEKLNETLELLPSLGTRTVLRHTLVDLWNIDGHVREYA
RLDRIADPLIVEPKGYVFVGYSRQRMTIQNMPSHEKIKSFSEQLAQELGYEFAAERSDSR
VTALAKDKGKMRIPGL
>A0A7K8L3F8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ardeotis kori|TrEMBL
LDVSSMDTWNFFYTCLVSLWLHRFYIYSAVAFGISLWIIIQFSTAKTKKKVTERTGDKLV
NGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVINMGDYDPDDCLA
EETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGNSV
YVDHFNTAGRNTDRWLWMLGASRVMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQAL
CRGKKKPCSGKCKKGKCKSSGKQNKESSDHEHQNASEYENPEVEELFETSSEEEGDAEEA
GGTNSVVDVEDLGNIMSHMKKAKVPLFQRGENCQVFVTVRIDGLICFLFSGYRLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRW
KMDQPEMILQEAIENHQNLIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINCF
VKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFL
DSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASNLT
MANVPWHEEVVHFVQELASLIPDYEIACEHEHSNCLLIAHKKFKINGEWCTWIDYGRFQE
LVREHERSGGSQAFTAADYAARTPRWALFGSGERGFDPLDVRYQRRNKARDISGC
>A0A832RW31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter thermautotrophicus|TrEMBL
MYLEESQRRMERMGYRFVGEHRHSAVKTCLWTKKSIVNEGVCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTGTAWEGPHDEPADIIDGAIEAQRKLLCGYLGNERADKIKVM
ESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLSEEPTQLYI
SLDAPDRDTYKELCRPQIPGAWDLLNSSLELMPSFSCRKVLRITAVRHINMKDPVGFARM
IERARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDESRESRVV
LLA
>A0A2H5UZE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon HR01|TrEMBL
MSQTIQSNPVAGRRVREEVRNLEKFVAAGYRIVGSHSAVKVCHWTKSALRGGKMCYKSWY
GIDSHRCIQMTPSVQYCNMMCVFCWRFHTPNRVEPFGGVWESPSEILDGIIKAQRELLSG
FGGNPKVSRERFKEALNPRHIAISLDGEPTLYPHLDGLIKEAARRGMTTFLVTNGTMPES
LRKLREGAEPTTIYLSLYGPDRETHIRTNKPLIPDSWERVMQSLEIIREMRCRKIIRLTL
VKDYNMHSPEKYADLIRIASPDYVECKGYTHVGESQKRLKRENMPSLEELREFGERLARI
LGYEKVTEDAVSRVVLLANPESPYFREMRDRVLTVGGTELLHPIQQPAVG
>A0A2D6W3U0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MKASKQIKEEKDLKNKKRYKEGYRLVGNHSAVKICEYCKKSLTGKDVCYKNTFYGIESWR
CVQMSPTFYCDHKCVFCWRNIDYTWPKWQGQVDDPKLIVDESIKAHIEYLQGFKGNKNAV
EKRLKEMEKPLHFAISLTGEPTMYPKLPEMIDYLKKKGLTSFLVTNGTIPGMVKKLIKHQ
PTQLYISVYGPNKEIYQKTANPIAGDSWEKLHKSLSMLPKFKRTTIRLTLVKGINMIKPE
LYANLIDKYKPMFVECKGYVWVGHSRERLMIENMPTHHEIMEFAKKIEKKSSYKVIDEKK
ESRVALLVRKDFKGRKMDFSGL
>A0A816D163|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFVRNSRT
FAQSTYDKLSKDLNRQVIIQDFNDVTDPEEFLQTQAKNQRTLLVFIPTYEDATPPPSAKW
FLLHLQEAATDFRVSKGELEKLTYAIFGCGNSLYFENFNKVAKEVDRCLSELGAKRLLPT
ELADENTAKSIYGGQEGHYSKWSSKLKSALETPKTEKCDCSNDTSTTTCCKTVTNGDHSI
KNDDNNNDEDEEEEPRIESDDDDEAGGCKDGNDDIIDLEDMGEYMENSSPTKTPKGPPKE
MVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSL
ACANKCVFCWRHHSNPVGTSWQWKTDDAKTVTQGAIDNHYKMINTFKGVPGVLPARLAEG
MKIRHCALSLVGEPIMYPHINELIEILHSKQISSFLVTNAQFPDEIRTLQPVTQLYVSVD
AATKESLKKIDRPLFRDFWERFLACLRALKDKGQRTVYRLTLVKGFNTEEIEQYAKLVEL
GDPDFIEVKGVTYCGDSGASSLTMANVPWHEEVVTFVQALCERLPQYEVACEHEHSNCLL
LANTKFRVDGKWHTWIDYDRFQELVARHKATSGAETFTSLEYMAATPDWAVVGANERGFD
PSDTRWHRKSTAKKDLSGC
>A0A2K6M763|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopithecus bieti|TrEMBL
MKLPVCVILNLDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQVVSKTQDRNLQ
EKSVPKAPQNLMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKKVTLAVNCPLAVTSKNVCV
FLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLGNSAYSSHFNKVGK
NVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQLQALQKGERKKYCG
GHCKKGKCESHQHDSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDRQSLNSIVD
VEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITAALREALTKQGYQLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPE
INRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFW
QRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFIEVKGVTYCGESSA
SSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKFKIGGEWWTWIDYN
RFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQRKNKSKAISGC
>A0A6P9CAK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pantherophis guttatus|TrEMBL
MDTPAETWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKNRLAELNLPK
IPAAEKEQQDPSLGKVHVAGVKVFYGSQTGTAKRFALVLTEAVASINLPAEIIDMQDYDP
DDSLIDEISSQNICMFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHGSIEADFEEEDFFETT
SEEESDIENGRGADQVVDVEDLGKVMGQMKKSQKEHQIDGEVPIGVGTQHSRKEDERREM
ITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRDDRFREGM
EAKHCALSLVGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLQALAEKHQRTVYRLTLVKAWNVEELKAYSDLVSLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVKRFVQELADLLPDYEIASEHEHSNCLLI
AHKKFKIEGKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAQERGFDP
TDTRFQRKNKTKDISGC
>A0A4Z2CAK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu bimaculatus|TrEMBL
MQGSSRVLFSLSNLTSFVTMFCVFAIVFLLIHHAFSSDSKEQQKSHISADYFMAIWHNRL
YLYSTAALIFGIWFSLKMAIKKKNQVSNANSLAYKPVKKNDNDSMVHVSGVKIFYGSQTG
TAKGFAKELSDEIKALGIPAVVLDMKDYDPDDELAVECTNKSVCVFLVATYTDGQPTENA
EWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGKRIM
TRAEGDCNVVKSRNGSVQADFLAWKVKLLKRLQALAKGEKKICSGNCKTEGKCKNKRKVK
GEENAALQNNSSEGELIESSSDEEESGLQEEKQSGTMLDMEDLGNIMNLVNKTKSNENGR
GKGQTVKLSKLNGLKKTEEEEDVREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDA
LEKHQNMIRQFRGVPGVKLERYEEGLQVKHCALSLVGEPIMYPEINTFVRLLHTHNISSF
LVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDYWPRFLDSLRALGEKRQR
TVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVA
FVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELRRHLREDGRTA
ELLSPRLHGQDSQLGCVWSSGTRFRPSRHAVPAAEQNQRHFRMLRGKEEFKNRSQDSKGQ
F
>A0A665U164|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
MTCLSTVSQNEHGTSESWFMSVWHNRLYLYSAVALVFGVWFSLNMALKKVRQVKPGSLVN
VNLPSIVQGFAKELSEEVTNLGIPSEVIDMKDYDPDDQLPDECTSKSVCVFLVATYTDGQ
PTENAEWFYRWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLS
GMRVMTRGEGDCNVVKSHNGSIQADFQAWKVKFLNRLQALAKNEKSCSGNCKTGSSCKNK
RNDGQLEVEKENDDLIESTSDEDESGLQDEKKSGAVVDMEDLGRYKLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEK
ILQDSLEKHQNMIRQFRGVPGVRPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSH
QISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALG
EKRQRTVYRLTLVKAWNVEEMQAYSELIAMGQPDFIEVKGVTYCGESSASNLTMANVPWH
QEVVAFVQQLAGMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYQRFQELAHVHEE
SGGLQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A662UET0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MITAKAELRGSDPILRIMNRLERQKYHHIGIHSAVKKCLWVHNALIYGRYCYKCKFYGIE
SHRCIQFTPSTLWCWNACLHCWRVRPQDLGLTYNDLTRLPYVDDPDILAEMAITEHRRTV
SGYKDRAPRKLWEEAMDPKHVAISLTGEPTLYPRFGELLEAFHRRGITTFVVTRGIRPEI
LSSLSIEPTQLYVSIESWNKDMYEYFNRPLTSRGWGKTLETLSLLQTYSSPTVIRITLVK
GFNMSPKDVKGFAKLLKDAEPTYIEAKAYMHVGGSTERLSRMNMPTLDEVMEFSKSLAEE
LGYSVVSYSAPSRVVLLSKLKNSVIRYGKGCPEGWKGGDEDAEALGEYSLPPSESV
>A0A565B0Z5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arabis nemorensis|TrEMBL
MATSSSIRARLAFVALLSATTFYCLHKYRRLKRLENLSLNPSSTTSKSGRGKIFFISETG
TAKALAQRLHELFESNGIGFDLVDPRSYEPEDLPKETLVIFIASTWDGGKAPQNGEFLVN
WLSESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMIGLGGLEMIPVGEG
DVDDGELDRAFQDWSDGVVRVLKGGSGQETSGISQXXXXXXXXXXXXXXXXXXXXXXXEI
VDLEDIAGKAPSRKNGVVVKVSNGDGKKEMVTPVIRASLTKQVQFLDCLTITVLFYGCDS
YAEHIRFLVFEYARCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKGALDL
HTKMIKQMKGVPGVTPERLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRISTFLVT
NAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQRTVY
RLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGTSATSKLTMENVPWHADVKAFSE
ALSLKSKGEYEVACEHAHSCCVLLGRTEKFKVNGKWFTWIDYEKFHDLVASGKPFTSTDY
MAQTPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVLA
>D5E8N3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus mahii (strain ATCC 35705 / DSM 5219 / SLP)|TrEMBL
MASDLLPDIGTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGISSHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPQKWDSPVEIMGSSIECQRNLISGFGGSASRELWQQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVPETIKRIKPSQLYMSLDAP
ERQTYMEVCSPKDPCLWDNINESLSILKNKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPGHEEVLDFANQLGCELGYEVGDQVEISRVVMLFRD
GKFVASKLPV
>A0A8J1TK49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Owenia fusiformis|TrEMBL
MSLTLWLLGNAYTLPGVVAIVTGGLLLWLILTLGKHNKDTIKVPDVDVTIATNDAVKNTE
DAGEDELRLKVFYGTQTGTAKNFSEELQKDVSQSFPEVHTEVINLKDFDPEDGFPEENLA
NLICVFIISTYTDGVPPEGATWFCKWLTETADDFRVQKTLFQGLRFGVVALGNSLYKGNY
NKIGKEVDRCLHQLSAKRITHVGLIDENVSESKHGGKEADFASWKSHFLDVLAEGTFPPL
KDHACECKQNGGKCSNKKTKENQFESSSDESDAEPIDGATEGVKQSNGLVDLEDLGKVVS
SMKKAKVRRQQEDEDKENNEPREMVTPLLRQSLEKQGYRLIGSHSGVKLCRWTKSMLRGR
GGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMNPAEEIFEGAIK
NHTNLIKQFKGVPGVQPERFQEGLKPIHCALSLVGEPIMYPEINKFVTMLHNDGISSFLV
TNAQFPEAIRDLVPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKELGDKGQRTV
YRLTLVKSFNTTELDNYSELVKLGRPDFIEVKGVTYCGESKASSLTMENVPWHEEVVNFV
KQLTDRLPDYEIAAEHEHSNCVLISHKKFKVDGVWHTWIDYPKFHKINNLYTDSKGAEKF
TAVDYMAPTPHWAVYGAREQGFDPQETRFHRKKKKDLSGC
>A0A3Q7XX78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ursus arctos horribilis|TrEMBL
MDPSLDTWDFSSPLMSLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSQEKSVP
KATQDLMTNGYISLQEKEVFVSGVKIFYGSQTGTAKGFAASLAEAAASLGLPVAVVNLKE
YDPDDHLVEEATSKNVCAFVVATYTDGRPTESAEWFCQWLEEASSDFRFGKTYLKGVRYA
VFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCDVAKSKHGSIEADFRAWKTK
FLAQLQALQKGEKKPCDGNCKRGQCESSAEEEPFESTSEEESGTEDHQNPNSVVDVEDLG
KIMNCVKKEKREKEQQEEKRSLVRNTVKNEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMVVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQLPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLD
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVRDLVDLIPDYEIACEHEHSNCLLIAHKRFKIDSEWWTWIDYNRFQEL
MQEYEDSGGSATFSAKDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A7K6I907|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dasyornis broadbenti|TrEMBL
LDVSMDSWSYFHTCLVSIWQHRFYIYSAVAFGISLWVVVQFATTRTKRKKGEKSHGNPAS
SEGAADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTARRFAKALAEAVISLNLPVEVFNMG
DCDPEDCLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAAHDFRVGKSFLQGLRY
AVFGLGNSAYVDHYNTAGRRLDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKA
KFLTRLQALCRGEKKPCSGKCKKGKCKSAGKQSKESSDHEHGVSEHENTEAEELFETSSE
EEAGGTNSVIDVEDLGNIMGHMKKAKVLLLEGLGSAVGGAVTSGLVGKSSTETMLFVILL
HCLKICALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPELILQEALENHQNMIKQFKGVSGVKAARWEEALAV
KHCALSLVGEPIMYPHINGFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDAST
KESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKP
DFIEVKGVTYCGESSASSLTMANVPWHGEVLGFVQELARLLPEYGVACEHEHSNCLLLAH
RKFQVDGEWRTWIDYGRFQELVREHQRSGGSRTFTAAEYSARTPAWALFGARERGFDPLD
VRFQRKNKARDISGC
>A0A5E4JMM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MQSTPALGCNLACVFCWRTIPEEEGYRWNELNAPDGWDSPKLIADGLICEHKRIVSGYKG
NERTDAKRLRESNDPAHVALSLTGEPLFYPRIGDLIGEFHERGMSTFLVTNGTMTGALRR
MSNMPTQLYVSVQAPNKKVYGKTVRPKSRSATWENFLKFLGVFSTLGTRRTFRLTLVRGL
NLTDPKGYAELIRKGRPHYVEVKGFVFVGGSRNPKRGLEFDQMPRKEEIVDFAKEIARES
GYLLVDYHKSSNIALLCSDEKAAADRMIKFRK
>A0A5E4J986|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MIPAGMLKELRGQKYLFVGKHSHSAVKICQYAKTSMTGGDSCYKNKFYGISSHRCLQCTT
VPTCFNRCVFCWRAQTGEVTSDPDSIQITEWDEPDEIIDELIRGQRHLLTGMGGHPNGDR
EKWVESQVPRHAALSVLGEPVVYPKFTELLGAFHSRGISTFLVTAGGAPSAIEKMMDGGI
LPTQFYLSLAAYDKTSYDEYVRPKGADGWERYNTSLDLMRKMKGKTRTVLRMTLMKGRNM
IHPEKYAEIIAKADPDYVEVKAYMAVGYSRKRVGMPGMPTFEEIRAFAGQLAEETGYIYA
DEHTPSRVVLLCRDESAKGNRFIDFSRIGKE
>F3KNE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosarchaeum limnium SFB1|TrEMBL
MSCSGEIVDEERLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPEKVAEPKEILTKLMAERKKLING
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEETKSIFLVTNGQEP
DMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWQRWNRTLEMLKKLDTRTVLR
ITLIRNYNDQEEMIPAFAAMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVRKFSE
SVAEHSQIFSVMDESLVSRIVILQNNQRTIDRWIPAYANTN
>A0A8C2ALM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FLSRFIHDVCSCTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRY
AVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKT
KFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSQSHAEKNNSEEELMESSSDAE
SSAEEEKSHGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKI
IQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQN
ISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGE
KQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHE
EVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEES
GGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A7K4BSS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosa archaeon|TrEMBL
MENVWSTLKRQKYKIVGAHSAVKICHWTKKSLVENRVCYKQRFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDPPLDYEVPEAIVEGCIAAQRELLSGYHGFLEKVDINKLKEAEN
PTNVAISLAGEPTLYPDLSGLIEEFRKRGFSTFLVTNGTTPDVLSSMDSYPDNLYITLPA
PTKEIYEHICNPQIKDGWEKLNESLELLQKIKTKRRILRLTLVKDFNMGDIEGYSELIEK
TNPDYIEAKAYMFVGYSRKRLEVENMPMFEDVLAFCKELEEKTGYKSIDFAKDSRVILLS
RN
>M0KDY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula amylolytica JCM 13557|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRGTFDSTVQAMDDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>A0A564Q580|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanolliviera sp. GoM_oil|TrEMBL
MSQYKEILKKQGDHLVGKNEHSAVKLCYWLKKSLRDEGECYKSKFYGIASHRCIQMTPYI
GCNQNCIICWRPTGMKTSFDEMDSPEEIVEASIKEQRRILTGYKGSYRTNMSKYEDAVNP
KHAAISLIGEPTLYPYLEDLIVEYGKRGLTTFVVSNGTKPEVIEEINPTQLYISLESFDE
EMYKKMCRPNGNDMWEKVLESLKILGEKRCRTVLRITLVRGLNFEPERFIPLIELASPDY
IEVKAYMHLGYSRYRLERDRMPTHGEVKDFSRILDDETDYSILDDAEKSRVVLLSKDKGE
DRMIDF
>A0A846NCK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSVVPSFPSLKEPSRLLSVLQRQKYHLVGRHSAVKRCNWLHRSLVSNRPCYKQRFYGIAT
HRCIQMSPTSVYCNLQCLYCWRVQPQDIAISWNELRPSEWDSPETIVEGCIREQQRILSG
YKDLVIKGKVHPKKFNEALSPKHVAISLTGEPTLYPHLGDLIGLFHRLGFTTFLVTNGTT
PRALEALEVEPTQLYVTLSAADEGIFRRIGRPLVGDAWRSLMETLELMPSLSSRGVIRIT
LVKDLNMMNPEGYARLIDRADPLFVEPKAYMHVGFSQRRLKRVNMPLHSEVKEFASKIAD
STGYSVVDDSPDSRVVLLASRKKPRGLK
>A0A1U8GB72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capsicum annuum|TrEMBL
MPLSLSSYPTRLTILTLLSATTLYFFYKSRRRLKSLNPNNPQTPKGKIFYISQTGTSKTL
AKNLHICLKLNGFEFDLVDPKEYEPEDLCKESFVLVVASTWDDGKSPENGGFFVDWLNES
VDDFRVGGLLLSECKFGVFGVGSGSYGDKFNVVARDFSRKLRKLGGVEVLELCEGDVDEG
NLDEVFGEWSERVVGVLRGENGGGGYMGNDEVGDVRDEEEYNDDDDDELEENDEGSGIVD
LEDIAGKGPSRKKGVGDNKLVNGKLNGGVVNGEKAMVTPVIRASLEKQGYKIIGTHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWTWKM
DDPIEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEINSLVD
ELHKRRISTFLVTNAQFPDKIRLLKPITQLYVSVDAGTKDSLKAVDRPLFGDFWERFLDS
LKALKEKEQRTVYRLTLVKGWNTEEVDAYSSLFSIGKPDFVEIKGVTYCGSSATSKLTME
NVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKMNGQWFTWIDYEKFHD
LVASGKPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRYKKERHHKSSRKENGSLKE
>A0A223ZFZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp. EMTCatA1|TrEMBL
MYLEESQRRMERMGYRFVGEHRHSAVKTCLWTKKSIVNEGVCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTGTAWEGPHDEPADIIDGAIEAQRKLLCGYLGNERADKIKVM
ESQDPTNAAISLAGEPMLYPDMDGLLREFHRRNFTTFLVTNGLAPMNLEKLSEEPTQLYI
SLDAPDRDTYKELCRPQIPGAWDLLNSSLELMPSFSCRKVLRITAVRHINMKDPVGFARM
IERARPDFVEVKAYMYIGYSRRRLDIENMPLFYEVHEFAEELAAASGMEIVDESRESRVV
LLA
>A0A1F8AIK9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus bombycis|TrEMBL
MAELFLTEGLVTLWHSYRLPILIAVTSVAIILHAYRRFQPKSKAVTASSIPPSPRSQSPE
KLDQIRTGEREKPAVAEKSVPKPAVGNDSVPKVSSGPKRVSGKKPLKVAGRRREDQGPPL
SFIQPIIFFASLTANTERYAQILLEDLRTAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPPTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAESALKEWSRGLQ
GILIDILDNGGLGEGVPGSGDPLESDEEDLDDDENDGKRTKRRNGQDVVDLEDIKMGSDG
QTGSGPVPVDFTTAGKSAAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNTELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVYKKGTKKALQAATE
>A0A087QWJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aptenodytes forsteri|TrEMBL
LDVSMDTWNNFYACLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASS
EGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGD
YDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLNGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWRAK
FLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFETSSEE
EADAEEAGGTNSVIDVEDLGDIMSHMKKAKRERELEEGDVGTSLTRENAGRKEEDEKREM
ITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLI
AHKKVRL
>A0A1A0HK46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metschnikowia bicuspidata var. bicuspidata NRRL YB-4993|TrEMBL
MDQTSILFAVCCAMYTLSGGRISLAIAVSVWVYIIRIRSPSTLPEKPSPILEVDFTHAYM
PNEKTVFPQTVPLSAKPKKVSKRSKFPRVFKGTKTLKSTLETALTSNAFKLLESPIYIFY
TTLTGSSHRMAKTLHEKLSKIEDLITPPKLLSLDDDVDDLEEFFLKTPKSSKPNIYLLVL
PSYETDSPIDYFLEHLQETSQDLNTPCSWGGEKFCYQAQLADRWMGKLGARRLFPLGQVC
MKHEGEPKALDWINRFAELLADDEPFHVDENDAVDDSDVEDEIDIVNDVVDVEDMGTIMK
ASNGTLLGMEPKQMVAQDSPTFKSLTKQGYTVVGSHSGVKICRWTKSAMRGRGSCYKFAF
YGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWEVDPPEKVLHGALEGHYKKIK
QMRGVPGIQMERFEEAFQVRHCALSLVGEPIFYPHINEFVGMLHDRDISSFLVCNAQHPA
NLEALDKVTQLYVSIDAPTKQDLKKVDRPLNSDFWERLIACLDILRTTQAHQRTVFRLTL
VKGFNMGDIKSYADMVERAQPSQIEVKGATFCGSSTGNGNPLTMQNIPFYDECKEFVESL
VEELNSRGQTYELAAEHAHSCCILIAHTKFHINGTWHTHIDYPKFFELLKSGQEFNALDY
VKETPSWALWGSDEAGFNPDDTRYDRKAEKLKKKEARDAQVAQAAQAKEVQNGI
>A0A372R2U3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus sp. MUCL 43196|TrEMBL
MLLRYFENLCLSYQALFWSCLAVGGIVVFYVTLLNSKKKKKQIIEDNKKIQELSAVNKEK
PTGKGLRKRFTRSTKKTSNQTCTNDSGEKSACCGNGGVSDCCKNQLSEATSNIITANKST
KISVKIFYATQTRTAKYFAQQLYQSFTKHSNCECSIMDIIEYETEDFLSESAICIFLIST
YNVEGPLDWFYKWLEDTRYDFRVDKQSLSKMKFAIFGLGDSAYGDQFCIQPRNIDKWLGQ
LGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDPSYALNNASSNLNYDSYSESDSDSD
NNNNSDTEMVDVEDIGALAPKLQAARKSKEEEEFVYKNSNGRPKRTLSEQEVPINEPKEM
VTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSHRCLETTPSLA
CSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLSNHYKMINEMKGIPGIRADRFQEAF
NVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMVCNAQHPSRLRALDKVTQLYVSVDA
STKESLKKIDRPLFKDFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEIANYVELVRRG
KPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFVKHLNENLGDTYEIATEHSHSCSIL
IANTKFKINNKWHTWIDYDKFFELLEKGEHFTSLDYIAPTPSWALFGSPEAGFNPEDQRF
YRKSKKNNNSVKNGGC
>A0A1B6DFS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clastoptera arizonana|TrEMBL
MTKTSFITPLIFNNLKQKNRNSLLILSFILLLACTLYFFEVNPQVWILLITILVFLRNIK
KNRQKSTKSSVIFFATENGKSKSFAYQLFEKLETVLSTEIHEIHSGIDGDPEWLFKKYGS
ADSLCIFIFPTHSEGKPPQSLSLFYHLVDELANDFRYDKTTLKGVNYAVFGLGNSAYKDN
FNVVGKQIDSWLDVLGAKRFLPVCLGDEDESSSKHGSIEQDFEFWCNSLIETIASWQENI
PLKIDYLKTQEDISEEEDEKEEENDGIMDLEDLGKVLSKQKDQEDGRIKEMITPSLRQAL
TKQGYKLIGTHSGVKMCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDGPEMILNNALTAHYNMIKEFKGVPGVISSRLKEGLIAKHCALSL
VGEPIMYPEIDAFIKMLHAKGISSFLVTNAQFPDAIRNLSPVTQLYVSVDGSTKESLKKI
DRPLFRDFWERFIDSLKALSEKGQRTVYRLTLVKAWNVKELDDYVQLVSLGRPDFIEIKG
VTFCGGGKDKSNSLTMENVPWHEEVIVFAQKMVAMLPDYGIASEHEHSNCILIAHKKFHR
NGEWCTWIDYNKFQDLVQNYYTSNGTLEFTAEDYMKPTPPWAVFGSIERGFDPVETRWHR
KAGSANLGGC
>A0A1J5CCQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon CG2_30_31_98|TrEMBL
MAKIKPANLKIFKRQHYSVVGNHSAVEVCSWTKKSLLNKGVCYKEKFYGIKSHRCIQMTP
AVAWCDFACLYCWRSHEYSQGTSMKGNIDDPKTIIDGAIEAQRKQLSGFKGNEKTNLKKW
QEAQNPFSFAISLNGEPTLYKKLPEFIRELRARKIISFLVSNGSHPQMLKKLYNSDSLPD
QIYISLTAINEKMHKNINCPLVKNSWKRILQTLKLIPNLKEKCRTIIRLTLIKDKNDSND
AAEKFAQLIKLANPNFIEIKSYMFLGYSRKRLKKENQCTHEQVRQFSKTLAGLCGLKVLD
EAENSKVCLIGMKKCARFDK
>A0A328E6J0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuscuta australis|TrEMBL
MPPSLSALSTRLAVLSLLSATTIYFFYKSRPHIRHLRNRLKALTELPARNPNHSSRGKIF
FLSETGTSRALAHRLHSFLALSDLPFDLIDPKDYEPEDLHKESLFLIVASTWEGGKPPSN
GGYLGDWLTESSDDFRVGALLLCNCKFSIFGVGSTSYGETFNAVAKDFSKRMRKLGAAEV
MEVCEGDVDEGNLDYVFDDWCKRLAIILKGDSRPYFSNNGNVEESDGEVSEHDDYDSEVE
ENVEDKGIVDIEDIAGKAMAGTRAKNGMVNGETLKEEKEMVSPVIRASLEKQGYKIIGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
RWKMDDPLEIVQTAIELHTKMIKQMKGVPGVKSDRLAEGLSPRHCALSLVGEPIMYPEIN
SLVDELHRRRISTFLVTNAQFPERIMMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWER
FLDSLKALKEKQQRTVYRLTLVKGWNTEDVDAYSNLFSIGNPDFIEIKGVTYCGSSATSK
LTMENVPWHSDVKEFSEALAKKSNREYEVACEHVHSCCVLLAKVDKFKINGQWFTWIDYD
KFHDLVASGRPFSSGDYMAPTPSWAVYGAEEGGFDPDQSRFKKERHHNRSAPS
>A0A3M1NGJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MKNQITTSARKSLEKQQYRLVGSHSAVKVCHWTKSMIRGRGGCYKFKFYGIRSHQCMQMT
TSLSCANRCTFCWRDYKAPVSKEWKWSIDDPEFILSNSLKAHEKLLIGFGGYDDRNDRAF
KESKNVKHVALSLTGEPIIYPKINELIRLFHKNRISTFLVTNGQYPEQLRNLERVTQLYI
SVDAPNRELLKEIDKPLFHDYWARLRKSLEIMAQRKDRSVIRITAIKDLNMCDEEGYAEL
IRLGDPDFIEVKGYMYIGASMKRLKRQNMPNHKEVKEWSSKLLKYLPDYELVSEHKPSIV
TLLAKKKFKGKTLIDFDKFFKEVITNKP
>A0A668UX57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis aureus|TrEMBL
MPTLIVFILLLASSVSASDSKVSQDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKK
KSVSKDSSKEENDKADKAPKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKALG
LPAEVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSI
QADFLAWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKTSPQNNSSEDD
LVESSSDEDESGLPDEKKTVLDVEDLGNIMNSIKKAKSKEESQRDGQMVKLSKLNGVQKI
EDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGV
KPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPV
TQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQ
AYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACE
HEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYDESGGQQTFSALDYVAKTPSWALF
GAQEQGFDPAETRFQRRNKSKDISGC
>A0A668V2S8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis aureus|TrEMBL
MRCSPVPRLLFSQLVSGWDLILFCCCMRSMVDARSPTESYFMWLWHSRLYLYSAAALVFG
LWFLLKKVRHLLIPYSNFSDKAPKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEV
KALGLPAEVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTD
FRYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSL
NGSIQADFLAWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKTSPQNNS
SEDDLVESSSDEDESGLPDEKKTVLDVEDLGNIMNSIKKAKVSKEESQRDGQMVKLSKLN
GVQKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFR
GVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIR
SLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWN
VEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEY
EIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYDESGGQQTFSALDYVAKTP
SWALFGAQEQGFDPAETRFQRRNKSKDISGC
>A0A2K5ISG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colobus angolensis palliatus|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFVVSISLWICLQIVIKTQDRNLQEKSVPKAPQN
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFAAVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYSSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QTLQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>H1KZB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanotorris formicicus Mc-S-70|TrEMBL
MEEIYQILRKQRYQIKNHTAVKLCGWVRKYLLENKSCYKSKFYGIETHRCIQCTPAVVWC
QLNCIFCWRVLPSDINMQKTFKEPKWDEPEEVFEEILKMHKTIIMGYKGVIDRVGEKKFE
EALNPRHVAISLSGEPTLYPYLDELIKIFHKNGFSTFVVSNGILTEVIEKIEPTQLYVSL
DAYNLESYKKICRGKEEYWEKILDTLDILGEKKRTCIRTTVIRHLNDDILKFVDLYERAN
VNFIEIKSYMNVGYSRKRLKLEDMLKPEEILELAKILDENSCYKFTDSSSDSRVALLMNE
NKKINPKINFEN
>M5XMC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus persica|TrEMBL
MAVARFGRQVKRPGGFCIKMTAVAILGLCFIFVWSMFSSSSSSVTTRIESFDNIGAPPGS
RNTRVNIPATQSSIKGEDEKKFNGSVTLSAHEHKSEKKDQKEVANVKKGKGKKKLPEKVS
KLKHGSEESESEDSEKEKEDEDEEREVVDGKEEALNDEGEVNGEETGGEGAFIVSLDQES
EEKLEDDGGESEERGKKRYKIKGPLFDPKAHYHWKLCSTRSKHNYIPCIDMEITTGRLQY
RHTERSCPRTEPMCLVPLPRDGYGSPVPWPDSKVKILYKNVQHPKLAAFIKEHSWVMESG
EYLTFPQNQSELRGGILHYLESIEEMVPDIEWGKNIRVVLDIGCTDSAFGASLLDKDVLA
LALGLKDDLVDLAQVAIERGFPALVSPFGNRRLPFPSGVFDAIHCGGCTIPWHSNGGKHL
LEMNRILRPGGYFVLSTKHDSFEDEEVMSKLAASICWNILAHKTDEVSDVGVKIYQKPDS
NDIYELRRKKYPPLCKENDNPDAAWYVPVKTCLHAIPSAIEQHGTEWPEEWPKRLERYPD
WLSDKDKLVADTKHWKAIVEKSYLTGLGIDWSNIRNVMDMKAIYGGFAAALSQQKVWVMN
VVPVHTPDTLPFIFERGLVGTYHDWCESFGTYPRSYDLLHVDHLFSRLKNRCKQPVSIVV
EMDRLLRPGGWTIIREKVEILEPLEGILKSLHWEIRMTYAQGKEGILSHRLLDLLTSNGL
AFDLVDPNHYEPEDLPKESLVLIIASTWDDGKPPANAKFFSNWLAESAEDFRVGSLLLSN
CKFAVFGVGSRAYGATFNAVGKDVAKRMRALGASEIFSIWEGDVDGGDIDEVFEAWSGKV
LRFLKGGVAENGGVLSNGVGAECEAESFDGSDEDEEEEDDVESEVVDLEDIAGKGPSRRR
TVTVTKTNGTVNGQKEMVTPVIRASLVKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHS
FYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAIDLHTKMIK
QMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHRRRISTFLVTNAQFPE
KIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLKEKQQRTVYRLTLVK
GWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPWHADVKAFSEALALKS
NGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSSGRPFDSKDYMAATPS
WAVYGAEEGGFDPYQSRYKKERHHRSNQ
>A0A3L6VUI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAKPVAVRILYGTHTGTAKGFATTLQQKLFALNVAGYAFEPSVVDMKD
YDQDNLEHEHVLISILSTWTGGVPPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLG
NSEYDEHYGKASKALSKHLSSLGASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYDA
LRSPAASSSSSPSVKPKQQPAGWKSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIV
LELDQGDDSDDEDNRPKKQDSGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYK
IIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNP
VGREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIM
YPHINEFCRELHAREISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFK
DFWERFLSCLTQLKAKGQRTVYRMTLVKEHNMKELDNYVELIHLGEPDLIEIKAVTYCGK
SDASDLTMQNVPYHQEVRDFCELLCAKLGGGYELATEHAHSNCVLVAKTKFKIDGHWHTW
IDYDKFHTLIQAYYKDGTPFTTMDYIAPTPAWAVYNAPEAGFDPIETRFRRTKEGKVVEI
EYTATDSGCG
>A0A7K8SN68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nyctibius bracteatus|TrEMBL
LDVSMDMWDHFYTCLVSLWLHRFYVYSVVAFGISTWIVVQFFTTKTKTKVTEHISKDKLV
NGSATLQAKEVYVAGVKIFYGSQTGTAKRFAKDLGESVISLNLPVEVISMGDYDPDDCLA
EETTSRNICVFMVATYTDGQPTESAAWFCKWLEEAVNDFRFGKTYLKGLRYAVFGLGNSA
YVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKQGSIEADFEAWKAKFLSRLQAL
CRGEKKPCSGKCKKGKCKSLGKQSKESSDHEHGASEYENTEAEELFESSSEEEADAEEAG
GTNSVIDVEDLGNIMSNMKKAKVLLLSHQDERGGKNIILSGRGKMIIEINVSALPVRQFY
LFLCYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSL
VGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLRRI
DRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDDLKAYADLISLGKPDFIEVKG
VTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKING
EWCTWIDYDRFQELVREHERSGGSKTFTAADYAARTPRWALFGSRERGFDPLDIRYQRKN
KARDISGC
>A0A7C2W4K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MRFSASNGGKNLGPKNGSVGEVGLDPNVVAILKKQGYHLVGKHSAVKPCLWPKKSLRGKG
LCYKGLFYGIKSHCCVQMTPSIFCNQRCLHCWRPIEILNFDDLAADIEWDAPESIVDGCL
REQQRLISGYKGAKTTDLKALEEARTPRHAAISLIGEPTLYPHLRELVEAFHERGMTTFV
VTNGTQPEMLRRIAPTQLYLSLNAPHEELYKKISGADFWEEIKESLKVLRRKGGEGVRTV
IRVTCIEGLNMEDVEGYASLIKLAAPAFVEVKAYMHLGFSRQRLRRDAMPSHKSVRRFAA
EIAEATGYSIAKESEISRVVLLTHSERPISTLLGHTAL
>H8I639|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocella conradii (strain DSM 24694 / JCM 17849 / CGMCC 1.5162 / HZ254)|TrEMBL
MSLIELLKKQGYHIVGGHSAIKPCLWLGRSLKGRGACYKSHFYGISSHLCMQMTPCIACN
QRCLHCWRPVEEPFAVKAWDRPEAIIEGCLREQRRFITGYGGILESDKQRWEEAFKPKHA
AISLVGEPTLYPYLDELVHQLSNMGMSTFIVTNGTRPEALEKVTPSQLYMSLDAPDRETY
MKACNPAVDLWDKVSESLEVLGARKNRRAIRLTLVKGVNMKDPEGYAALIKKAMPDYVEV
KAYMHLGYSRNRLPRDAMPKHEEVMAFSKKVADVAGYRLASDVELSRVVLLSKDGGKKAI
K
>A0A328S0C8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. rholeuAM6|TrEMBL
MIISDLQRKSLEKKGYRFAGKHVHAANKICHWTRKSIVDEGVCYKEQFYGIKSHRCLQMS
PAVPYCQHKCLFCWRDTDITKTSWDSDDYDDPRTIIEDCIENQKSLLCGYFGNDKANPKK
LEECVSPNNAAMSLAGEPLLYPEINQLIHEFKRLNFTTFLVSNGENPEAIRKLEEEEPTQ
LYVSLDAPNEETYRRVCLPQVEHGWQKLNESLELLSTLDTRKVLRITSVKDLNMNNPEEY
AKIISKCDVDYVEIKAYMFVGDSRNRLEWENMPKSVDIENFARSVASECGFEVIDEVAKS
RVLLLGDKKPVKYNNE
>A0A5C9E2J3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPEQLQQKLQSQGYHLLGDRGAFKACQWQRRSLLDGETCYKQRFYGIQSHRCLQMTPVVD
KCTQNCQFCWRVTPSDLSVSWDQINVRNEDVLQPSELLELVFRANLQSLGGYNPEAGANV
SENKYHEARNPRHVAISLSGEPTLYPFLGEFIELIKNEGMTSFLVSNGTKPEVLMEIHPP
TQLYITLAAPDESTYQKLCRPLVKNGWQSVVESQRALASIDTRTVNRLTMVKGLNMHNPR
SYAKLILEGEPDFIEVKGYMFLGSSRDRLDQDNAPSHRDIQGFSEKLADLTGYYLTDEQI
ESRVVLLSKKRNMKKLS
>A0A2A9MND1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Besnoitia besnoiti|TrEMBL
MWLPYSLDPCLVSVLSKYSEFPSSSSSPSSAEAAPCAASTAAELAGPASPSLRVLILFGS
TGGTSAAVAFSLFQSLRDSLLQANDPKGDASLPLEPRQQPRGEPRNEENSCGESRGEGVL
RQDGSAPHAEARVCGKKMTRGKGSAASKRGDGAAFGEGARAAEQALKRAEARQAELKNAG
ADAASDSAAKSPRFLDSACAGDVELYIQSTQFFSFDDLLAIAESRVAPPQASRLPRGGTE
ASRGNENAEALRDSASNSSSQNASQRATRLGPASPDCASGSLSRPVRLILLFCVSTASQG
SPPPAAAAFFADAEEAAADFRVGRNVLSSCFVAGVGCGSSDYPPSTFCRPAKKLFKLLTT
QLGARPLALVPVSLEAAAAPGAAAAAAPLASASSLLLLSDTQSNSSLEMKTLKWTREMLQ
RAATIRQAPPGQAERLAERAASEEARQKGRQKARAEARASLSLAPGEKENVNAPEHSSSS
SSSDSEGSSDYSESSSPSSASSSADEEEPDAGAGWQTPDSPFAGGGATAGACGAEADDLE
DVIPCGAEGGDEALAPEAAGQAGARGARNGLSGGDPGGRSPAGGSYGVSSGGPATGREKG
RLDKRKKMVSEKQAMQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSSQC
MELTPSLACANKCVFCWRHHKNPVGTSWRWQQDSPDFIVEQGLKKHFEAVKVLKGMAEVK
EDRLASARAEVRHCALSLVGEPIMYPRISELVQNLHQQHISTFLVTNAQFPDALQTLPPV
TQLYLSVDAANAADLKRLDQPLFADYWERFLSCLELLKEKRQRTVYRLTLVGGYNMEDPT
AGDSAAESSCHGSESLAEGTGAASCSCRVPPPQASSTEASTGEHGPREDAERIPAGTHSR
RKAPGESLTDRSAAAYANLVLRGSPDLVEVKAVTYAGTSKHSKLTMQNIPWHEQVVTFCK
ALCDALPAGEYAIACEHRHSCCVLIAKTSYRRNGVWHTWIDYDKFYELANSGNTEFSGLD
YCAPTPSWAVYGSVEAGFSPFETRVFSKGKQKRALRDQGQMRSGDASGANGNDDAAKNVA
VEE
>A0A524LDX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPTELKEKLEKQGYHLLGKRGAYKACQWQKKALLHGDACYKQRFYGIESHRCVQMAPVVD
KCTQSCDFCWRVTPADVGVSWDQITVEKDDVVPVNELMDAVLVANLRSLGGYNPDAGAQV
PRKLYAEAREPKHVAVSLAGEPTLHPQISDLIDEIHSRNMTSFLVTNGTRPEVLEKMTPP
TQLYITLAAPDETTYKKLCRPGIKDGWQRIIESQEVLQSLNTRTVNRLTMVSGHNMKNSR
QYSDLILKGEPDFIEVKGYMFLGSSRDRLTNENAPTHRDIRAFSRKLADLTGYHLVDEQI
ESRVVLLSQSKYIRKL
>S9V741|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigomonas culicis|TrEMBL
MLSTLLYIVLLPFYICIHATVMVTLAFVFLIWYLTSRSQEQDAKTLDKDTDQFQAEVRQH
IDDRKVAPAGAAKKECKAQTAATATATATPTPTPSSHRAEVPTVASPVEDAAAAPEEEPL
TPPEHEQHSPHPPHILIAYATYSQNTLQLAHKLYSQLQTFFYEKKVEFESLPQNAKKVYV
MPKIKILELREAEEEGLLPATTDATRVKRKTPLQRSCSVDTILYDANYYLTIILTSTFSE
GRAPPRSQAFELLLQDAAEDHRIDRNILRNKKFCLFSLGDIHYGAGVFNLFGKNLCRQLK
QLGAPALVVPPVFSTEEKMNLLFKIFCEGLLKFLTKVEFVKKENYEALLDGFYDADNAKT
QPEETEDDHVKRVSRDGGTQQDYLPALYDMKIHKAGVTSKAKRGQARDSTHAGGGYCCSD
SSSNYMGSPNVMNKSEKEAAGADSGDKPCGCQAQKKEMENVDSAEEDDDDDDDDAEVDEE
EDLEDLLNTNDEDGEGGSSSAAPREPRPLLYPRLQKNLEKQGYKIIGTHSAVKLCRWTKN
MLRGRGGCYKFSFYNIKSYQCMEATPSLACANKCIFCWRHHTNPVAKTFLWKQEAPEFII
EEGLAAHKRMIRQMKGVPGVTVENLAAAMNVRHCALSLVGEPIMYPQINHFVELLHERRI
SSFMVTNAQFPEEIARLQPVVQLYLSIDAPNAVLLKEIDRPLFEDHWERCLRSIDALAKK
KNTRTVFRLTLMNERNDAHIAEYVNLIQRGSPDFIEVKGVTFCGTSNSNSIDMKKNVPQH
QQVIQFCQALCDELARRYPHYRTPQMEPDAAGDNKADVDDDKVIVIPPEERHRPYHVACE
HEHSCCVLIAHEKFFFNHRWNTWINYDKFFDLVNAPHDDAPEAGGLHEEVEEVDVFNNRP
SANGERLRQYAFTSLDYTAPTAKWATYRSQERGFDPKQTRVIRNKARPTVTATTTSTSL
>A0A1Q9NVT3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain AB_25)|TrEMBL
PIELSEKLEKQGYHLLGKRGAYKACQWQKKALLHDTSCYKQRFYGIQSHRCLQMTPVVDK
CTQSCEFCWRVTPADIGVSWDQVEVSEADVIPVNELMDAVLMANLRSLGGYNPKAGAPVP
EKKYKEARTPKHVAISLAGEPTLHPLISDLIDEIHDREMTSFLVTNGTQPDVLSTMSLPT
QLYVTLAAPDEDTYKTLCKPGIRGGWNRVLKSQETLQSLSTRTVNRLTMVANRNMHNERA
YAKLIDMGEPDFVEVKGYMFLGSSRGRLDQTNAPSHREIRAFSEKLAALTGYHLLDEQIE
SRVVLLSRSKQIKKL
>A0A662KCN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNEEIKAILKKQHYAIVGNHSGVKLCHWMRQSLLYNRVCYKQTFYGIETHRCLQMTTAIN
HCTQTCLFCWRYQGFTEKEINKPDDPEFILEESIKAHRKLITGFKGDKRCDLKKWKEANE
PKHVACSLTGEPTIYPRLDEFFEVCHKRGMTTFLVTNGTNPDVLEKLDTLPTQLYVSVTA
PNKEVYKKLCRPLISNGWERLQKTIELLPSLDTRTVIRHTLVNGWNMKEEHIREFAKIDE
KASPMFIEPKGFVLVGYSRERLTIDNMPFHSQVRDFATKLADFLGYYFIDERPDSRVVLL
SKEKEVKKLNR
>A0A662KPS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MEKNMQRIFQKQGYAIAGNHSVVKLCHWLRKSLLYNKQCYKHTFYGIESHRCLQMSPAAF
HCTQKCLFCWRFQGFTEISMDKKNADDPESIFEKCMEEQRRLVSGFKGDERCDEKKWEEA
REPRHVACSLTGEPTLYPFLSEFFEICHRHGMTTFLVTNGTVPEALEKMDVLPTQLYVSV
SAPNEEIYKKLCCPLVKNGWEKLNETLEMLPSLDTRTVIRHTLVNEWNLGYEEEYARIDE
KAEPWFIEPKGYVFVGYSRQRLTLKNMPSHDKIKKFGIKLAELMGYEIRGEREDSRVVLL
GKGKREKI
>A0A6P7WTD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microcaecilia unicolor|TrEMBL
MDAPVEISDYLYAYFMSFWINRFYIYSCAAFVVGIWIFLQFITIKKKKQDESPYQNGVVQ
YGGEDVHSTQKEKETHISGVKIFYGSQTGTAKGFATSLAKEIISLGFLAEVLDMKDVDPD
DSLIEQTTSKNVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRVGRTYLKGMRYAVFGL
GNSVYVNHYNTVGKNIDKWLWMLSASRIMTRAEGDCNVVKSKHGSIEADFDSWKSKFLSQ
LQMLCKGEKKSCGGKCKKTNCKSKKKKTGEGLDHDQQALGESEHDNTEEELFETTSEEES
GAEEREGTGSVIDVEDLGKMMGHMKKAKKERELAERSGKVGPFQEKNGMGEDGEAREMIT
PALRDALNKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNLIRQFKGVPGVKADRFEEGLSV
KHCALSLVGEPIMYPEINRFIKLLHQHRISSFLVTNAQFPQEIRILEPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALADKQQRTVYRLTLVKAWNVDELKAYADLVSIGKP
DFIEVKGVTYCGESTASNLTMANVPWHEEVIHFVQELTNILPDYEIACEHEHSNCLLIAQ
KKFKIDGEWWTWIDYDRFQELIRMCEDNGGCKTFKASDYMAKTPQWALFGAKERGFDPMD
TRFQRKNKTKDISGC
>L9WJ80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum sulfidifaciens JCM 14089|TrEMBL
MSNSAETGVDTGPDAERNEGDGDGGAMQVSSPDYHSENHTAAQTCGWTANAMRGEGKCYK
NIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVQWDDPEAVVDASLNLQKRL
LSGFGGNEEVPREVFDQAMEPRHVAISLDGEPSLYPYLPELIEAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMAVLADKDETRTVLRTTL
VKGENMHHPDWYAGFFQQADPDFIEMKAYMHVGHSQGRLDRSAMPDHEEVVEFTEQVQEY
MPEFTECKGVPASRVALLSKTKDTWVPKLKKDSEFWARDPVTGE
>A0A842MLS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MQDFAEILKKQGYAVVGKHSAVKLCYWLRKALIKKIPCYKSTFYGIESHRCLQMTPAAYH
CTQKCLYCWRFQGLTLEEIKKEEADEPKFILEKSIEEQKRLLSGYKGNEKVSIREWNEAI
EPKHVACSLTGEPTLYPFLSDFFEECHKRGMTTFLVTNGTNPEAIEKMDTLPKQIYVTIS
APNEEIYKRLCCPLIKDGWKKINETIELLPSLNTRTVIRHTLVRHWNLGYEEEYAKIDEK
SDAWFIEPKGYMHVGYSRERMRSNNMPSHGEIRKFAEKLAGLIGYKIEDERIDSRVVLLG
RGKKREI
>A0A101XF33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermocladium sp. ECH_B|TrEMBL
MEEVQEERLKYHEVIGGKIKIKIDTRAELLKSKYGVYGHATVELCHWTKSSLXGGPSCYK
YKFYGAPVGGSHRCVEFGPMGMVCSNRCVYCWRPTDAFDSITPGSDEVMEPEDLLNGVLA
ERRRLLSGYXGHPEGKKKIREALEPTHFAISLSGEPTLYPKLPELVKLIRSLPNTKSIFI
VTNGEHPEAIERLVEENALPTQLYLSCNAPNKALFNKINVPVMKGEAAWDSWLRTLKMLP
KLGTRTVVRITLIKGWNTDPKYVPEFAELMRAGSPHFIEVKSYMHLGHSVYRLGKENMLN
HEEVREWANKLLRELGTMYEFMDEDVNSRIVVLRNTERRIDRWIEKPTT
>A0A7U2I0U2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)|TrEMBL
MSLLDGLAQLPAELLLIWHDHRVPILFSAIALAAIVRLAIYARGRRDKVSASPLPGTPIE
KKKIELRPEWLPENTTFNASALNVDGHAEDDTGAVATVAKIKKGPKTVKGKKTPKKTGVP
APSFNHTTDKIQPVVFFQSLSGTTERYAKEFAKVLTEWTTGCDQASSFLELQLHDISYIE
YDDFFISPPKVDANVKQFYIILLPTYNIDTVLDNFLENLQETHNDFRIDTAPLRSLLGYS
VFGFGDKEGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMGDTKTDAADRLQEWRLGV
QEALVEIAEGRGLGEGVVGSGDPAESDEEEDIEDGTGQSTRVDEIEELGSMVDSSSTPIP
VDFTTYKSKSKPLVKSSAAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDGIT
AAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLEIMHSNRISTFL
VCNAQHPAQLASLVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGDAGLTMQNVPFYE
EVAEFVTELEKELSSRGLTYGIGAEHAHSCCVLLADRTRFMPNGKWATRIDFERFFDLYE
GKVEGTRVEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDQRVYRKGKGPKNDEEGDGG
KVIEIKAKNEALEF
>A0A7L1VER4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sitta europaea|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRLYIYSAVAFGISLWIVIQFTTTRTKRKVTEPVTDKLGN
GCAPPQAQEVHVAGVKIFYGSQTGTAKKFAKALAEAVTSLNLPVEVINMGDYDPEDGLAE
ETSRRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKGFLQGLRYAVFGLGNSAY
VDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQLQALC
KGEKKPCSGKCKKRKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEEEAEGTDSVI
DVEDLGNIMGHMKKAKREQDMQEGAAGAGRKEEAERREMITPALREALTKQGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWR
WKMDQPELILQEAMEKHQNMIRQFKGVAGVRAARLEEALAVKHCALSLVGEPIMYPHINR
FVRLLHQHGISSFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRF
LDSLKALAEKQQRTVYRLTLVKAWNVDELTAYADLISLGKPDFIEVKGVTYCGESSASSL
TMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYGRFQ
ELVREYERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRRNKARDVSGC
>A0A0D8DP13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidiplasma sp. MBA-1|TrEMBL
MINTYKPIYKKQHYGLVGNHSAVKVCHWTKSQLTGHAACYKNTFYGINSHQCIQMTPALN
ACSENCDFCWRFQGFDSMHISQEDDPEFILEESIKAHLKLISGFKGNPKVKKELFEEAQH
PKHMAISLTGEPTLYTRLGELIEAATKRGISTFLVTNGTLPMVLEKLDPLPTQLYVTVAG
PTKKIFNDVLHPAIGNAWENFNRTLEILPSLDTRKVIRHTLVKDVNMPYYDEYEKLDRIA
SPDFIESKGYVHVGQSMDRLAYENMPSHEMVLEFSNELARRLGYTPYADRYESRVAMIAK
DPSKAKIDFEAELKKHMK
>A0A0D9VZL6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leersia perrieri|TrEMBL
MPPFPTATSSVSTTSHLALLLLLSSSSLFFLYKSLRLRRTTNPPSPSPSPNPTPPLLLYA
SATGTSKSLAAALSARLAAESGGGVAAHPTDAAGLDPDDLPTVPLLLLVLPTHDGGAPPQ
SAAFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVE
VVAVGEGDVDGGDLEAVFEEWCGKVVRVVKGEEIEEGHKGESDGFDGLELEEEDSDDDDD
EEGEVDDGEVDMEDIAGKAPARKRNGKVEGALPNGGGENGLREMVTPIIRTSLEKQGYKI
LGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GKSWKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMY
PEINVLVDELHRRHISTFLVTNAQFPDKIKTLKPITQDSLKSLHDKDQRTVYRLTLVKGW
NAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALALKSGG
VYEVACEHAHSCCVLLSKVDKFKINGKWHTWIDYDRFHELVTSGKPFKSKDYMALTPPWA
VYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A2H9Q876|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG_4_10_14_0_2_um_filter_60_11|TrEMBL
MDFYERYLQSLPRLRKAGYAFVGNRKHSAVKVCLWARRALCGKGSCYKQKFYGIKSHRCL
QMTPAMPSCNQRCLFCWRDTSLFSEAWPLDGADEPSEIIDGAVAAQRLLLIGFKGNASAD
RQKWLEAQEPNQAAISLDGEPTMYPKLAELIREFHRRGFTTFLVTNGTRPEALRHLAAED
ALPTQLYVSLCAPDEETYEKTNLPVGDDNWTKLNETLMLLPSLATRKVLRLTLVKGLNFH
SPERYAKLVKVSGVDYVECKSYMNVGFSTQRLTQAHMPSHDEIRAFAAELAGNAGYEFTD
EQVESRVVLLSRDAEAARNRFITRV
>A0A545VAS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cordyceps javanica|TrEMBL
MDPLGGGYGQSALFNINGLLDVWHSNRTPIILLALCGLLVLRLYLHVYEAKSDLKTIPKL
YEKVPSEKLDTVPQRQGREKPVVKTTGPRRIKGGVTKKPETSEEPIDLNKPVKILVFFSS
ITTKTEKIGQDYIAKLERSVVRLAAETKRPILAPELLDLTEIDFDDYFIAPPKSDDGAQF
LYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSALLGYSVFGFGDREGWPDEAEGY
CFQAKELDKWMAKLTARKRAYPVGMGDMKSDHVQRFVEWTNGVEEVFGQIIRTGHLGQGV
PGSGAAVESDDELEEDYDDGEVVFDEEKSPSKRENGKKSSNLDDVEDLGRMIKSQGGDAN
PKAPIAVDFTTYNNSKGSVQNKAKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWTKSA
LRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFD
GVKENHYKKIKMMRGVPGVRAERFAEALRIRHCALSLVGEPIFYPYINEFLGMLHKERIS
SFLVCNAQHPDQLADLKAVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNRCLDILREKR
FRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLSMSNVP
FYWEVCDFVRALDKRLQEKGLAYGIAAEHAHSCCVLLASERFHVNGKWHTHIDYDRFFEL
LEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVVREAPE
>A0A846N929|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilaceae archaeon|TrEMBL
MSCSGETIEEEQLIKIKPLIVKQLKKAKYGVSDHSTVGLCHWTKKSFRNEGSCYKHKFYG
ISTHACMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPEHVAEPEVIMSKLMEERKNLIMG
HKGDPRSDERLIYESLKPSHYAISLSGEPTMYPKLPELIKYLKTLEETKSIFLVTNGQEP
EMILKLQKENALPTQLYLSTNAADYESFIRINKPKYDDSWERWNATLQMLKNLDTRTVLR
ITLIRDYNNQKEMIPAFAKLLEESSPNFVEIKSYMHIGRSTNRLQHENMLDMEEVREFSK
EVTKHTKNFSIMDESYISRIVILQNNERKIDRWIATYQNTN
>A0A5E4ADU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marmota monax|TrEMBL
MHRFYLYLGFAFGISLWICVQILIKKQGKNSQERSIPEAAQDLMTNDYASLPKKHIFVSG
VKIFYGSQTGTAKGFATILAKAVTSLDLPVAVINLKEYDPDDHLVEEIASKSVCAFLVAT
YTDGRPTESAEWFCKWLQEASSDFRFGRTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKW
LWMLGARRVLARGDGDCDAVRSKHGSIEADFRAWKTRFISRLQALQKGETSCGGNCRRGK
CESKQHGTEDEEPEPLALAAQQPRDTEEEEPCESSSEEEYGAGEHQGRNSVVDVEDLGKV
MDLVNKEKREEEQQEEKGLFGSRGKKEGGEGRAMLTPVLREALTKQGYQLIGSHSGVKLC
RWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQ
PEMILEGAVENHLDMMKQFRGVPGVKAERFEEGMKVKHCALSLVGEPIMYPEINRFLQLL
HQRKISSFLVTNAQFPEEIRKLKPVTQLYVSVDASTKDSLRKIDRPLFKDFWTRFLDSLK
ALAEKQRTVYRLTLVKSWNVDELQAYAELVSLGSPDFIEVKGVTYCGESAASSLTMANVP
WHEEVVRFVRELVGLIPDYEIACEHEHSNCLLVAHRRFKIEGEWWTWIDYGRFQELVQEY
EDSGGSKSFSAEDYMAKTPPWALFGARERGFDPKDTRHQRKNKSKDVSGC
>A0A088E818|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metallosphaera sedula|TrEMBL
MAVKGSFRIDTLSKIREEMEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMTPVSMWCWFRCIHCWRLEPEDVGLDWDETKMPYMDDPEYIVERSIEEHKRSVSGY
LGREGVENNKALEAMKPSHVAISLTGEPTLYERIGELIREYHKRGITTFLVTSGVRPDVL
ASLEEEPSQLFVSLQAPNEEKHRLINRPVVANSWNLVMKTLEILPSFSSPTVIRMTMMKE
VNMSDDDAREFAKLMRIAMPTYIEVKAYMHVGPSTYRLTKDAMPRHSEVRFFAEKLAELT
GYKIISEHAPSRIVLLSTIDRPMQIGNAWTEKWDWRTQDTQDDVNGEYREAEMGCTEEGD
GPKP
>A0A7C4HQ39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MSTNHAVKLRREEFWGSSPVYKAIYERLSKQGYHIIGVVGAVKRCHWTREAVLRHRFCYK
CLWYGIESHRCIQMTPVVVWCWNRCLHCWRIQPEDVGMHWDDTRPPVTDDPGVLVEESIR
VHRQIMAGFKGNPKADLKMVEEAMNPKHVAISLSGEPLLYPRLGELINEYHGRGLTTFLV
THGTRPDVLKNLDKEPTQLYISFEAWNKDSYEYFNRPMVPRAWELFQETLEYVRSFKSPV
TFRITLVKGFNDREEALKSFAKFVEKGNPHYVEVKAYMYLGVSKSRLTKSSMPLHREVRD
FAGKLSELTGYTLLGESIPSRVVLLSRIEKPLRHGKGCVEGIKCPEKYAPVITDEYEEAE
A
>A0A7R9PW48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Medioppia subpectinata|TrEMBL
MVNQHFFSHENTCEANECQTKCRPKTCRILYATQTGTSRQLSLQLDSFLRHTLSQDIDHK
KMTISLNAINEYEPEDSLVSDANNNAIIIIVMSTYSSGSPPSDGKWFCQWLQDFSNDFRV
DKSSLKGLSFAIFGVGDKAYGQHFCRISQDMDRWLKQLEATPIVSTQLSDISDSSGFDKQ
FKQWMNELSLKLSNNSLTESKTYSEDTKEDVEEDEPNDNRTKIVDIEDIVNKSSKEKMSS
NGIIKDMITPELRKELTKQGYRLIGSHSGVKLCRWTKSMLRGRGLQCLGGCYKHSFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWSLDDPELVFAGALSNHYQMINEFKGV
PGVQTQRLNEAMKVRHCALSLVGEPIMYPHINSFVRMLHNKQISTFLVTNAQFPDAIKQL
DPVTQLYVSVDASSKQSLKRIDRPLFRDFWERFTDTKGQRTVYRLTLVKSWNVEELEGYA
YLVGLGNPDFIEIKGVTYCGTGKDTQLTMANVPFHEEVLNFSRDLLKHLNSSCESEGNVK
YGLSCEHKHSNCVLIASTKFLIDNRWHTWIDYDMFARLIDEYYRSEGTKTFSSLDYIALT
PEWALVGSDERGFDPNDTRFYRNRKNAAQLECCQPLKMNSTLNTIDEQIICELNSDINSN
TNRIDQKAFKDVHKNVIYKVVPPMANDSTNGNGFIVIEESDGSSPPTPVSSGSDHKITDG
FGFTSTQKLSQEMRRLRQLFDILSDQSDVDHPLCEECADFVIDQMDHQLRQLEDESKEYN
DYLNLIQSEQSVDPNVNESEICELTERFKSLETIEKQLTQELNEVKEQQKKANEDIDKQS
HELKRLYEEEDKYWHEYNNIRHQIFICEDEQQSVDNQLRYAQNLFDKLKRTNVFNATFHI
WHSGPFGTINNFRLGRLPTVPVEWGEINAAWVPYGNHSFLESLEDRSRELPLYASGGIRY
FWNNKFDNAMVAFLDCLTQFKQHIQTQDSEFVLPYKMEKETIEETNIGAKYSIKIQFNTE
EQWTKALKFMLTNLKWALAWVSAQFLNNQSVPRPQQSRSHPSVAILLLQTRPFVPNDPVC
VLGSQKSGVSSE
>A0A1N7C296|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena daqingensis|TrEMBL
MSNSAETGVDSGTDAEEGEDDGAMQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKYIY
YGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDGVEWDDPEAVVDASIDLQKRLLSG
FGGNDEVPREVFEQSMEPRHVAISLDGEPTLYPYLPELIDAFHDRDITTFLVSNGTRPEM
LRACDPTQLYVSVDAPERHTFDEVVGAMEDDAWDKLLETMNVLAEKDETRTVLRTTLVKG
ENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSAMPDHEEVLEFAEDVKSYMPE
FTECRGVPESRVALLAKQKDTWVPKLKKGSEFWERDPVVGD
>A0A842ZYP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNPELEKILKRQHYAIIGKHSGVKLCHWMKQSLLFGRECYKQTFYGINSHRCLQMTPAIT
HCTQMCLFCWRFQNFTEKELHDVDDPGYILEHAIEAQKKLITGFKGDPRCDQKKWKEANE
PNMLACSLSGEPTLYPKLGEFFEACHRKGITTFLVTNGTTPAALEQLDPLPKQLYVSVVA
PTEELYKKICAPLISNGWEKIQQTLALLPSLGTRTVIRHTLVHDWNMDEKYIEAYAKLDA
QASPTFIEPKGYVFVGSSRNRLHFSNMPTHDQIRNFGQKLAEQLGYEQVMEKADSLVVLL
SSQRKNRKIK
>A0A2E7J433|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIASRLSKQRYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLHKIDDDPYELYLESVRGHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDVCHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQNAFHKLEQTLEILPSLDTRTVCRHTLIKHESLGFHEDYARLDNLA
DPDFIEAKGFVFVGNSRNNLSIENMPSHADVMEFSEKLAPLVGREILSERRESRVALIGR
EMIPITLPEKTRELPDSLGIAKPQNFSLPQA
>A0A2V4CYN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHLVGEHGGVKICHWTKESLLRDRSCYKGKFYGIASHECLQMSPVVD
QCNLACTYCWREPHMDSLELTDQDPLELLYESVRAQRRLLTGYGGNIAASPEKFIEAQNP
KHVAISLNGEPTLYQNLSEYIDLCHQHGMTTMLVTNGTLPKAIENLDVLPTQLYVSVDAP
NEEVFNRICKPKWGSAAWQKFEQTIDLLPSLDTRIVCRHTLVKGENMNPEHLAQYAALDN
RADPDWIECKGYVFVGHSREVMSLENMPSHDDVLEFANTLAPLVDRRLLDDSRPSRVALV
GREKIPLPIPEKIMDFPEDLGIAPPIKHLTLAKATEN
>A0A346PTP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrarchaeobaculum sulfurireducens|TrEMBL
MSDSDGGPSQVDSPDYHSERHTAAQTCGWTANALRGEGKCYKNIWYGIESHRCIQMTPVV
RCNERCVFCWRDHRGHAYELEDVEWDDPEAVVDASLDLQKRLLSGFGGNEEVPREVFEEA
MEPRHVAISLDGEPTLYPYLPELLEAFHDRDVTTFLVSNGTRPDILRECNPTQLYVSVDA
PERHTFDQVVKAMEDDAWEKLLETMDILAEKDETRTVLRTTLVDGENMHHPDWYAGFYQL
ADPDFIELKAYMHVGHSRGRLDRSSMPDHEAVVSFAEDVMAHMPAFTECKDVPASRVALL
SKTTDTWVPKLKKDSEFWARDPVTGD
>A0A2I1E884|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizophagus irregularis|TrEMBL
MLLRYFESLYLSYQALFWSCLAVGGIVVFYVTLLNSKKKKKQIIEDNKKIRELSAVNKEK
TTGKGLRKRFTRSTKKTSNQTCTNDSGEKSACCGNGGVSDCCKNQLSEETYHIITANKST
KISVKIFYATQTRTAKYFAQQLYQSFTKHSNCECSIMDIVEYETEDFLSESAICIFLIST
YNVEGPLDWFYKWLEDTRYDFRVDKQALSKMKFAIFGLGDSAYGDQFCIQPRNIDKWLGQ
LGAKRLYPLGEGDKNSDQEKNFEAWKKSLVDMLFDPSYALNNVSSNLNYDSYSESDSDSD
NNNNSDTEMVDVEDIGALAPKLQAARKSKEEEEFVYKNSNGRPKRTLSEQEVPINEPKEM
VTPMLRKSLTKQGYKVVGSHSGVKICRWTKSALRGRGSCYKFCFYGIQSHRCLETTPSLA
CSNKCVFCWRHHTNPVGKEFVWKVDPPEMIFSECLSNHYKMINEMKGIPGIRADRFQEAF
NVRHCALSLVGEPILYPHINEFIKLLHDRHISSFMVCNAQHPSRLRALDKVTQLYVSVDA
STKESLKKIDRPLFKDFWERFLECLDILSQKGQRTVYRLTLVKDYNTEEIANYVELVRRG
KPDFIEVKGVTYCGYGGASKLTMANVPYHNEVISFVKHLNENLGDTYEIATEHSHSCSIL
IANTKFKINNKWYTWIDYDKFFELLEKGEHFTSLDYIAPTPSWALFGSPEAGFNPEDQRF
YRKSKKNNNSVKNGGC
>A0A2G7FIT1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus arachidicola|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILVRAYRKFQPKSKAVTASSIPPSPRSQTPE
KLEQIRTGESEKPVVVEKSVLKPATANDPAPKVVSGPKRVSGRKPLKVAGRRREDQGPPL
SFIQPIIFYASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
DILIDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAALSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKGLQAATE
>D9Q026|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobus saccharovorans (strain DSM 16705 / JCM 18335 / VKM B-2471 / 345-15)|TrEMBL
MEERQVEEKEIYNMLNQKLVKQGYHIIGNHSSVKKCYWNHAALVEGRFCYKGKFYGIESH
RCIQLSVTNHWCWNACLHCWRLRPQDVGIEWNETRMPFADDPKEIVEKAIQEYRRIISGY
KGRPGVSPQMYKEATMPKHVAISLTGEATLYPRLGELIREFHRRGISTFLVTRGVRPDVL
ANLEEEPNQIYISLESWDKESYNYFNRPLVPRAWELTLETLEMLPSFSSTTVYRITIVKG
YNDNETALKGFARLVDIGRPDYIEVKAYMYVGASRGRLRLDNMPRHWEVKEVAKKLSELT
GYPIVSESMPSRVVLLSKLEKPVRYGNAPVDWNSPDISAPGEYEDTA
>A0A4Y7K381|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Papaver somniferum|TrEMBL
MTLSSSIPARYALLALLSASTIYCIWKSRRLLQLKLSLQNPNPNLANTKGKIFFISQTGT
SKALANRLLDLLKLNGLDFDVINPKDYEPEDLPKETLVLIIASTWENGKPPSDGGFLANW
VAESAEDFRVGSLILSGCKFAVFGVGSRSYGENFNAVGRDFSQRFRALGASEILPLCEGD
VDEGDLDDVFDVWNQKLIGVLKGENLNENGEVNGDECASESEYEDYSDEEEEEEETDIVD
LEDIAGKGPSRNSKAAATVKVAANGEKEMVTPVIRASLQKQGYKIIGSHSGVKICRWTKS
QLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDDPLEIV
NGALEQHTKMIKQMKGVPGVKSECLAEGLVPRHCALSLVGEPIMYPEINTLVDELHRRRI
STFLVTNAQFPEKIRSLKPITQLYVSVDAASKESMKAVDRPLFGDFWERFLDSLKALIEK
EQRTVYRLTLVKGWNAEEIDAYYDLFAIGKPDFVEIKGVTYCGSSATSKLTMENVPWHAD
VKAFSEALALKSGGLYEVACEHVHSCCVLLARTDKFKVDGQWFTWIDYEKFHDLVASGKP
FTSKDYMAATPTWAVYGAEEGGFDPDQARFKKERRHRTK
>A0A133V1M2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA261C02|TrEMBL
MMLSIEAKTNLEDSGYRIVGQHQHSAVKTCRWTKKSILDQGFCYKQKFYEDVHGIKSHRC
LQMTPSLPFCDHRCIFCWRNVDLNSPTWQGEADEPTEILDGAIEAQRLLLSGFKGNPNAN
KKKWEEAQNPNLCAISLDGEPTLYPKLSELIEECHHRNIVPFLVTNGQHPEHLEEISEPS
QLYISTVAPDEKTYTQICRPLVTNSWERLNESLELMPSFNCVKVLRLTLVKGWNLKDPSG
YAKLVEKAEPDYIEPKGYMFVGHSRKRLQMNNMPTHEEIAQFAEKLEKLTGYKITDESEP
SRVVLLSTE
>A0A662R0W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MEEYLKRLRKQRYQIVGSHSAVKGCLWLSKSMRGLEFCYKGKFYGIQSHRCVQMTPSIEC
NQKCIFCWRPVEFDFRVDKWDSAEMVAEGVVDAHKRILWGYKGSPKTDMNRFQEALTPKH
VAISLIGEPTLYPHLPKLIKIFEEKGMTTFVVSNATNPEMVEKINPTMLYLSLDAPDRDT
YMKVCRPRSDYWDNIVESLSIMGNRKGEIKRAVRITLVKNLNDFDIHSYGELLKLASPDF
IEVKAYMHLGYSRNRLSRGSMPSHEEVMNFALQLAEKIGYKIADQSRVSRVVLLTEDGSK
DMFIGG
>A0A397GAU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus thermomutatus|TrEMBL
MAEHSTTEGLTKRDPSTCIMLTDSSLLGILAFWHSYRLLFLVALSTVFVGLRFYRKLQSR
TKTTASSSVPPSPRSQSPEKTEKGIPLESSNPATTQKAERQLPAANGTAKLTSGPKRVTG
RKPSKVAGRRGQTEDAEPLSFIQPIIFFASLTGNTERYAKILLDELRAGAQKRADLQDRE
RGLLPPQIHDLSYIDLDDYFTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNET
HNDFRIDTGSLSSLAGYSVFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGL
GDVKSDAESSLKEWSQGLQDILFDILENGGLGEGVPGSGDPLESDEELDDEDVGKSKAQN
VMDLEDIKFGGDQTAAGSPIPVDFTTIGKSAPGQSTEKEMVPKTSPTYAALTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGT
TWRWKVDSPELIFEGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLDMLHGEHISSFLVCNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFW
ERFQRCLDILREKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGT
STSAGAGLTMQNVPFYEEVAQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFHVNG
KWHTRIDYDRFFELLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKH
LQITAEP
>A0A3L7HP42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cricetulus griseus|TrEMBL
PALSAFAGGLWGLGSAEDGFYIYLGCALGVTLWICVQVVIKKQVIRSQEKSVPGAPDSSF
SLQKKQTHVSGVKIFYGSQTGTAKGFAVTLAKAVTSLDLPITSKNVCAFLVATYTDGHPT
ESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQSHFNKVSTNVDKWLWMLGAQ
RVLTRGEGDRNAVQSKHGSIEADFTTWKTKFISRLQTLQSGEKKACSGDCKKGKCETTQP
DSGEMGPHLQGKLHPRDVEEEEPCESSSEEELGTQDYQSLNSLVDVEDLGNIMSPMKKEK
REKAQQEEKAGVNRNPEKSADSEGRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKVDQPELILKE
AIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQHGISS
FLVTNAQFPEEIRNLRPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKKD
>A0A837AY06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Porcisia hertigi|TrEMBL
MIAFLLQLLVSVGLPLVAFLLYNHLANSAHARRKASTTTTSAADGVEDIENFTQEVQREL
KQLGVAFSPPPEALVQSAPPPSPPAQQMTPSPTVVAASSVPSTSPPEILIAYATQSQNSL
ALAHKLFSLITAQLQTTTTTMTTEGAVCPMVRVMEMREDEEANNTASSPAPAIARVGRQN
VCRVDTLLEQNQYALIIFIASTYTDGVAPPRSQAFEAMLKDAFEDHRVPRDTLARKRFAV
FGLGDIAYGERRFNTFAKNLHEWCRGLGAPPFVVPPVYATEAKTQSLFRIFSTTLLNWLS
RATFEADGTVIVRKKSEMAAAGLVAAGARTSKAGRAAATTTKPSTTSDAREAACGNEDGS
CCCQASPASNDAAANENSDSEDEDGDNAEQDDMDDVEDLVWDGTDDAEFDLNKDPNELPE
LLYPKLRQSLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSL
ACANKCVFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLATA
MQIRHCALSLVGEPIMYPQINGFCDLLHAHHISSFMVTNAQFPEQLRDLKPVVQLYLSID
APTPEELKRIDRPLFEDYWDRCLSCVKELAKKPQRTVFRLTLVNQYNTENVKAYADLVEM
GKPDFIEVKGVTYCGTSPSSTLNMKDNVPRHDEVIGFCKAICAEMARRQPHYRTPQMNKV
AEGCGGSDDDEAIVIPVEERNRPYHVACEHEHSCCVLIALDKFFFDDRWHTWIDYERFYE
LVESGRTDFTSLDYAATTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTAGC
>A0A3A5HDF5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp|TrEMBL
MALSKENLNKLEKMGYRFVGRQGHAAAKICHWTKKSILNEGVCYKEKFYGIDSHRCLQMS
PSIPFCHQKCLFCWRDFSATESQWEGKYDEPGEIIEGCIEAQRKLLCGFFGNEKSNPEKL
AQSQNPNNAAISLAGEPLLYPVIEDLIDEFHRRSFTTFLVSNGMSPEKLKNLESEPTQLY
ISLDAPEKKIFNDLCQPQIPGSWEKLNKSLEILPSIDCRTVIRTTCVQKRNMVNPEGYAR
LIKKAAPDFLEIKAYMFVGYSRQRLEKENMPDFKEVNEFASAIGNLCGMEIVNESPESLV
VLLGNK
>A0A5N5U3E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halosegnis rubeus|TrEMBL
MSDTGPKQVDDPEYHSRNHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKC
NERCVFCWRDHAGHAYELDEVEWDDPEAVVDASIELQRKLLSGFGGNDEVPRRVFDEAME
PRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLDACDPTQLYVSVDAAD
RHTFDETVAAMEDDAWERLLDTLDVLAEKDETRTVIRTTLVDGFNMHTPEWYAVMCERAD
IDFLEMKAYMYVGHSRSRLGHENMPSHEEVKAFTERVGEFLPDHDTFREVPDSRVTLLSR
DEDTWVPKLKGGSEFWS
>A0A7C0TWS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MVKEGITVLYSRLKSQKYHIVGSHSAVKKCHWTHATLLERRFCYKCLFYGIETHRCVQMS
PAVLWCWNRCLHCWRFRPSDAGIDFDDTRLPTVDDPEFIADMVIKEHLRILSGYFGNPKA
DKELLKEAMEPKHVAISLTGEATLYPRLSELIEVFHKRSLTTFLVTRGIRPDVLASLSEE
PTQLYISIEAYSKETYNYFNQPVVPNGWELTLKTLEILPSFSSPTVLRITLVKGFNTHEK
AIHEIAKIIEIAEPTYVEPKAYMHVGASITRLRREHMPTFSEVMKFSKKLAELTGYYLVT
YSVPSRVVLLSRFKKQPFRYGKGCPGGWSRPDEGSEESGEYGKLKHLV
>A0A833DDE4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLINDRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLHKIDDDPYELFLESVRGHRRLLTGYGGNPKADPEKFREAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIERLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDKAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPDFIEAKGYVYVGNSRNNLVIENMPSHQDVLDFSHRLAPLIGREVLSDRRESRVALIGK
EMIPITLPEKVRELPRDLGIAKPQRYVLPQA
>A0A6V8D451|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGKFYGIASHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLGEYIDLCHKHGMTTMLVTNGTFPKVLERLDPLPTQLYVSVDAP
NKKVFNEVCKPKWNKRSWEQFEKTIDLMPSLDTRIVSRHTLMKGINMSDQHIREFAALDN
RADPDFIENKGYVFVGNSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GQEITPIPIPEATMFFPENLGIAPSVKHLPIIQ
>A0A2H9LEX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Diapherotrites archaeon CG08_land_8_20_14_0_20_30_16|TrEMBL
MPNLELNQSLIKDLQNKHYGIAGKHSAVQICEWTKKSLRNQGECYKHWFYGIETFNCCQV
SPNVMWCDQNCIFCWRPQENMQKKLIKEKVDSPKKIIEDLIKAHYKLLSGFKGYPNINKK
KLEASLNEIPSHWAISLSGEPTLYPKLPEFIKTLQKKGVKSIFLVSNGQNPTKIKDLHRK
KALPTQLYISLDAWNEHSYRKINKGIHRNAFKRLLSTIKVLNNLACRTVIRLTVIKGLND
NKKTIKEFGKLIEFGQPDFLEIKAYMWLGYSRKRLKQENMPSHDEIKKFARALEKYLPSM
KYEDENIPSRILLYKNNAKNRKKKIPNRYIIPKKDWRFV
>A0A497SS22|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MLIPENVRKILISQQYRIVGLHSAVKICHWTKKSLTENKVCYKEKWYGIKSHRCLQFSPN
VIWCDHHCLWCWRIQSGDRANLVWKEFPFEPEKIDEPKEVLIQAIEARKELLSGFKGNPK
VDRQKWEEAIKPTSIAISLSGEPCLYPKLSELIEESHKLGMKTFLVTNGTLPEVLEKLSL
PWQLYITLPAPDEETYLKACRPLIKDGWERINKSLELFPSLDCRKVIRLTLVKGLNLKNP
EKYADLILKAEPDFIEAKSYMHVGESQKRLKKENMPSMEDIRIFAKRLAELIGYEYKDED
LASRVALLTRK
>A0A7J2TXQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MEEEKEPILKEGKIRIDEELAKKLRDAQYGIFGHSTVDVCHYTKKALKKEKVCYKRKFFG
IETHRCMEFSPAGLFCHNRCIYCWRPTAFYKTLKLKEDKVDEPKEIVENLLKERNKLLTG
FGGNEKVDKELYXEALIPTHFAISLSGEPTLYPKLPELIKYLKSLPQTKSIFLVTNGQEP
EMLERLEREDALPTQLYLSMNAGKIETFNKVNCPLMKDAWERFNRSLEFLAKTRTRSLIR
ITLIKGFNDSKDEIEDFAELIKKGNPHFVEVKSYMHVGYSKSRLTENEMLSMDEIREWAS
DLQKLLPNFEFMDEDEEARIVILQNRERYVDRWILRLDESSLFKFGL
>A0A7J2MU38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIPEELLKIYRKQGYKIVGKYGAVKLCTWLKKSIKNEGFCYKQKFYGIESHRCLQFTPCL
TFCTQQCIYCWRSFQGTETFMKEWDDPKLLVEESIKAQRELIIGFKGYKGTDLKKFEEAM
NPKHAAISLAGEPTLYPEIDELIEEFHKRNMTTFLVSNGTMPEVLERMKNLPTQLYISVS
APSEEVYRKVCRPLLKDGWQRLNRSLEIFRTLKTRRVIRLTLVRELNMIDPKGFSKLIEK
ADPDFVECKAFMSVGFARKRLPYESMPLHEEIFKFAEELCEELNYKIIDEKRDSRVVLIG
KSERGVKIN
>A0A7C0X8Z0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus veneficus|TrEMBL
MEEKPEIERTIPQKLLKDLKGYQIVGSHSAVKLCLWLKKSMKDLGVCYKQKFYGISSHRC
LQMTPALLCNQNCIYCWRPRELLPGVKGWDPPEFIAEESIKAQHRLLSGFGGIKVNERKL
REAYEPNQVAISLIGEPTLYPYLDGLVEEYKARGMTTFVVTNGTNPAVIEKIEPYQLYIS
LTAYSEESHMALNRPAKSFWDRIMQSLKIMAEKDGRRVIRLTLIKGYNMDPEKFVPFIDR
ASPDFIEAKAYMHLGYSRLRLPRTAMPEHSDVKAFAEKLAKLTGYEVKDESEISRVVLLA
R
>A0A0A7LBA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoplasma termitum|TrEMBL
MDESYRELLIKQQYRLYKDHAAVKLCHWMKESMIHGRHCYKQDFYGIESHRCLQMTPAIN
ECSHCCSFCWRVQERDFEVRDWAEPKEMLDALIAHHRLLISGFKGDPRCSKQMFEEASDP
NQVAISLAGEPITYPYLSDLIKECHRRKMTTFLVTNGTYPDQLGSLDELPMQLYVTIAAP
NEEIYKKVCRPKINDGWGRLMKTLDLLPSLDTRTVIRHTLVKDLNFGWVDEYGKLDNRAD
PDLIEPKGYVFVGASRQRLSLTSMPSFEEIRDFSSQLGDIVGMSIIRERPDSRVLLMAKE
DLDTDVRNTPRIRSRNRKI
>T5AJV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243)|TrEMBL
METPNWLSGLRSDTAIDDVVEFWHAHRTSLILCTFFVLVSIRILLYRYEEKVELITLKQI
YQKTESHTVTAQSVSSLLEKTTVTKSNGPRRIKGGLAKKTAQSEREDVDLTRPIKLVVFF
SSVTTKTEKIARGYLASLDKAAEELSQETKRQFQKPELHDLSDIDFEDFFVSPPKSPDDA
RLFYLFLVPSYNIDTINDTLLQHMEETHHDFRIDTAPLASLLGYSVFGFGDREGWPNEAE
GFCFQAKELDKWMSKLTGRKRAYPVGMGDMKNGHAQRFAEWAAGIREVVGNVARNATLGE
GVRGSGDAVESDEEDAADENDQEELEDDPDIEKTTSRALDDVEDLGKMLRTSKDDGNAQN
PRAPLAVDFTTYGSSTKTSQAPAVKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKS
ALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIF
EGVRENHYKKIKMMRGVPGVRADRYAEALKIRHCALSLVGEPIFYPHINEFLALLHAERI
SSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREK
RFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTSTSSNAGLSMSNV
PFYWEVCEFVKALEKRLRAMGLAYGIAAEHAHSCCILLASERFKVDGRWRTHIDYKRFFE
LLEERGPDGEWTPEDYMGAPTPEWALWGNGGFDPRDQRVDRKGRAIENTVIREQPPAEVW
>A0A1I8GUI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macrostomum lignano|TrEMBL
SRHPLLLSVANLRRRLVSNTGAWFCKWLAEAAEDWRVERGHLSGLRFIVIGLGNSLYAEN
YNLIAKRVDEQLTQLSGTRLRPPVLLDENVASATGHGGQEADFQAALQSQLLDPLVSKKK
KSACCSEATGNSACCQGAEAASDVAEDHSDVDSDHLDEEDQDGLVDVEDIGGVLSSATRS
NQKQKLRQEATTRRAMVTPLVRKSLEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAF
YGIASHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWLEDPPDEILSGALDAHRRMIRE
FRGVPGVMPERISEGMQPRHCALSLVGEPIMYPRINQLLHLLHTSGISSFLVTNAQFPEA
MRQLPPVTQLYVSVDAATPDSLKRIDRPLFKDFWQRFIDCLRAMRDCGQRTVYRLTLVKA
WNTE
>A0A7R9ESU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema bartmani|TrEMBL
MITIFGVPFFGASFMPTLVAVVTIYIAWSWFAKKQNGNKICSLEAINAVTTDSLSRQVVE
NGKAPLISIDDKVGPKKIVAKTRKKSCGGKGGKCCGSKKGKSKCLTIEGVIERLKVFYGT
QTGKSKVFSMILAKSAEEKSLPVELVDLSTYDPEDKLTEEQAPPPYTDKPLRGLTTHSAF
RHKGRYLGDTFRRHQERGFLKKQPGQAGRPYSHLGTVPCGCVVDGLLIFSQTSGQSLCVF
VLPTHAEGKPPEAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQYADHFNEVGRS
VDHWLHKLQAMRVAKLGAGDEDTVASRHGSIEADFDDWQNALMGCVEKWRAKSNCRCGGK
SQPQEERIEEASSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNFSSALRAARKRK
ESEESEGTREMITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFYGIES
HRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALDAHYKMINQFKGVP
GVKPERLAEGFQAKHCALSLVGEPIMYPEINKFVKLLHQKEISSFLVTNAQFPEAIREMS
PVTQLYVSVDASTKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYRLTLVKAWNVDE
LENYAKLVEIGKPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQKLADLLPEYAIA
SEHEHSNCVLVAHKKVDLYFNLIELSRIPCFDYMRKTPDWAVYGSSEQGFDPVETRWHRK
SNTTKDISGC
>A0A8C5DT42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
FPPSVCDVYSGSEKYLLWVWHNRLYLYTAAALCFGLWFSLKMVLKKVRKSVPSDLVLWVQ
KSAEKNDRAEVHVSGVKIFYGSQTGTAKGFAAELSEEVKTLGIPSEVIDMKDYDPDDQLA
DECTSRTVCVFIVATYTDGRPTENAQWFCKWLEEASTDFRYGKTYLKGLRYAVLGLGNSA
YVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQDDFLAWKAHFLRRLQAL
ARGDSGSRSSKSSCMKTDGADHEGEEPTLTNHSSEEELMETSSDEEQSDERTSGSVVDVE
DLGNLMDSVKKSKVPETHQKVSSILLLFRKRKLWILYPRVCLRNMYSRVKSLFAGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWLWKMDPAEKILEEAMEKHQNMIRQFKGVPGVLPERYQEGLAIKHCALSLVGEPIMYPE
INTFLRLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFW
PRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVTYCGESSA
STLTMANVPWHQEVVAFVRQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWRTWIDYE
RFQELVEAHEASGGTRSFSALDYMSQTPHWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A5P9NZE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum aibiense|TrEMBL
MSNSAETGVDSGSDAERSEGDGDGGAMQVSSPDYHSENHTAAQTCGWTANAIRGEGKCYK
YIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVQWDDPEAVVDASIELQKKL
LSGFGGNDEVPREVFDQAMEPRHVAISLDGEPTLYPYLPELIDAFHDRDITTFLVSNGTR
PEVLAECDPTQLYVSVDAPERHTFDQVVGAMEDDAWDKLLETMAVLADKDETRTVLRTTL
VDGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSAMPDHQDVVDFAEDVMSY
MPEFTECRGVPESRVALLATQKDTWVPKLKKGSEFWERDPVTGN
>A0A2K3MTL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trifolium pratense|TrEMBL
MPLSSVSTRLTLLALFSATTFYCIYKSRRLRNLKLNLSLNPNPNTNTKLNLPKILFISET
GTSKSLANRLHRFLSLNDVAFEIIDGRSYEPEDLPKETILLIVASTWEDGKPPPAYRFFA
DWLAESSEDFRVGSLLLSKCRFAVFGVGSRGYGETFNAVGKEIVKRMKALGGAEMIPLFE
GDVDGGDVDEVFDKWCVKVVELLKGGGGEDGGDLENGEEECGVLSSDEEESDDEEEEEVE
SDIVDLEDIAGKAPSRKSVATVAETNGKLNGGKKQMVTPVIRANLVKQGYKIIGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWQWEM
DDPLEIVNSAIEQHTNMIKQMKGVPGVTLERLNEGFTPRHCALSLVGEPIMYPEINALVD
ELHRRRISTFLVTNAQFPEKIKSLKPITQLYVSVDAGTKDSLKAIDRPLFGDFWERFIDS
LTALKEKHQRTVYRLTLVKGWNAEEVDAYYNLFSIGEPDFIEIKGVTYCGS
>A0A842L7D0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp|TrEMBL
MDVKPNMPEEITNLFKKQHYALVGHHSSVKLCHWLKESIKNNRVCYKQKFYGIESHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPKPFDDPAFIVEESVKAQRKLLSGYWGVKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGELVEEFHKRGFTTFIVSNGTEVEVLEKMMKEN
KLPKQLYISLTAPDEETYQRVNVPMIPDGWDRINKTLELMRDLPTRTVIRLTLVKGENMH
NPEGYAKLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIKAFAEELVKNLPGYHIE
DEYPPSRVVLIMRDDLKKADRVIRH
>A0A2G9N8A1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_44_13|TrEMBL
MGGSYRKELEKQQYRFIGDHSAVKICAWTKKSLTDKGHCYKQKFYGIESHRCCQISVTVN
FCDQDCVFCWRKRHNEPFSGFSKIDEPKEIIENAIKYQRLLLSGMGGNEKVRDRQKLKEA
QNPNQFAISLTGETLYYPKLSELIRELKQRKCTVFVVTNGQLPEVMEKMEPPTQLYMTLA
APNAKIYKKVCRPSNKDYWERLNRSLEALKGMKLKKKTRTAIRLTLVKGYNMAEPENYAK
LIEKAEPDFLEVKAYMFVGASRQKLEKANMPYHKDIVEFAKEIEKHSDYRIVDEQKESRV
VLMTLNGRPGHSVKIG
>A0A5D2M8S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium tomentosum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPQHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSAGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A1D2RFW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon IMC4|TrEMBL
MVDPKYKKLLERQNYKVVGNHSAVKVCAWTKKSIRDEGVCYKEQFYGIECHRCLQMTPAV
ASCTQKCLFCWRSLEHTESPAKWDDPSFIIENSIEAQRKLLSGFGGNPDVNKKKLAQAQD
PNQAAISLSGEPTIYPKIDELVGEFNRRRFTTFLVTNGTLPGRLSKMENLPTQLYLSVDA
PNEEIYRKLCNPLDSACWGKLNETMDLFPSLGTRRVIRMTMVKGWNMVEPQGYAKIIGRA
QPDFVEVKAYMFVGASRERLTLENMPSNDEVMDFAQRVAEESGYDVKDEKRDSRVVLLGK
>A0A7R9E1R5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema monikensis|TrEMBL
MITILGVPFFGASFMPTLVAVVTIYIAWSWFAKKQNGNKICSLEAIDAVTADTLSRRVVE
NGKGPLISIGDKVGPKKIVAKTRKKSCGGKGGKCCGSKKGKSKCLTIEGVIEGLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEETSGQSLCVFVLPTHAEGKPP
EAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQYADHFNEVGRSVDHWLHKLQAV
RVAKLGAGDEDTAASRHGSIEADFDNWQNSLMGCVEKWRAKSNCRCGGKSQPQEERIDEA
SSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNFSSALRAARKRKESEESLGTREM
ITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLA
CANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALDAHYKMINQFKGVPGVKPERLAEGF
QAKHCALSLVGEPIMYPEINKFVRLLHQKEISSFLVTNAQFPDAIREMSPVTQLYVSVDA
STKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYRLTLVKAWNVDELENYAKLVEIG
KPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQKLADLLPEYAIASEHEHSNCVLV
AHKKFQVDGEWFTWIDYDKFHELVQKFYSTNGESSFTALDYMRKTPDWAVYGSSEQGFDP
VETRWHRKSNTKDISGC
>A0A2I3SEV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pan troglodytes|TrEMBL
LDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGSHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDSERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAVKYTLRYLINASIFFLETGSCSVTKARTQWHHHSSL
EPPTPGPKRSSCLSLPSTGTTGTYCHA
>A0A285NR10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronoarchaeum philippinense|TrEMBL
MSDSNGPKQVSDPEYHSENHTAAQTCGWTANALRGEGKCYKYAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELDDVEWDDPEAVVDASLRLQKKLLSGFGGNDEVPREVFEEAM
EPRHVAISLDGEPSLYPYLPELIDEFHERDITTFLVSNGTNPEMLARCDPTQLYVSVDAH
NRAMFDDVVKAVEDDAWERLIDTMDVLADKDDTRTVLRTTLVEGENMRDPDWYAAFYDRA
DPDFVELKAYMHVGHSRGRLDRSSMPDHEDVLAFTEEIGAHMPDHDTIKDVPQSRVALLA
RDADTWVPKLNKGSEFWARDPVVGD
>A0A319ADS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus lacticoffeatus (strain CBS 101883)|TrEMBL
MEGSGNEGLLAFWHSYRLPVLLALATLLVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTFSNSTEKDVGTDSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPAVSFI
QPIIFFASLTANTERYAQVLLEELRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSRGLQDIL
GEIVENGGLGEGVPGSGDPLESDEEDLDDEGSESDKANGRKRNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPF
YEEVQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQAAAATEAQG
>A0A430LYH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium euwallaceae|TrEMBL
MDWANYSAPSRLDSFVEELVDVWHIHRTPILVAALVVLGTLRIYLTFIGRKTELVALTEA
YKEPPKPKAVVEAKTPAVETIDEKKDVKPQGPRRIKGGIARKPSKKNEQEKDITRPIMVL
IFFSSITTKTDKIAQAYLKELEVKQEELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKMH
GDVDYFYTFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPT
EGEGFCFQAKEVDKWMAKLTSRKRAYPVGMGDMKSGHEERLQEWTKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDIAEDEDDGEVLFEDDDTSDPKKKNGRPLDDVEDLGRMIRKDD
GSTVQKAPLAVDFTTYSSTKKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPD
LIFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHA
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLEIL
REKRNRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCEFVKALEKRLKQKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKK
FFDLLEERGPDGDWTPEDYMDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A0B7N4Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Parasitella parasitica|TrEMBL
MSNFINSLLYGFTNILSVGPEQPIEGQAEQEGCSGSNGEGCCKNRESTATAEQSATRAKS
GCCQEESAGDACCSSSSVALDGITATTISATKREDGCCQSTTGKSSCACESASNEPVIIE
NLKIIFSTLTGTAKTMAKEMQDKIEANDRVTVHNVKVMDVTEYDNDNLLQETAICVFILS
TYNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAANNIDKWLG
RLGATRIYPLGECDKNADQKGQFDVWSNGFVSELEDKHSLEFSPTNFAFQSDDEDDQESA
GEEEGGQPDINIDENGSGDEMVDLEDMGNMASKIKAAKAKRAEEEEDFEISKAKAKRLIG
TDVGNKPKTAPQAREMVSPMILKNLTKQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAF
YGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQ
LKGVPGVKAERFQEAFTIRHCALSLVGEPIFYPHINEFVTKLHENNISSFLVTNAQFPDK
IAEMVPVTQLYVSVDAATKDSLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKG
HNTAEIDGYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRQLVAKLD
GDYEISAEHAHSCSLLIAHKDFKINGEWYTHIDYPKFFELVKSGKSFTSLDYMAKTPDWA
LHGHEAAGFDPNETRHYRKNRKTVVPPTIPDMTTTA
>A0A7L1S4C5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Locustella ochotensis|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPSSPEV
TADKLGNGCAPPQVQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLHGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFL
TRLQVLCKGEKKPCSGKCKKGKCNSSGKQSKESSDHEHGTSEHETTEAEELFESSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNGTGIHNPAHGSAHCGFTFKAIFLPGGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIM
YPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFK
DFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDFIEVKGVTYCGE
SSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCLLMAHSKFQVDGEWRTWI
DYSRFQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPSDVRFQRRSKARDIS
GC
>A0A4W6CX17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Barramundi|TrEMBL
MLNFFLILLLFIIHVSASDSKVPRHEPSPGESYFMSIWHNRLYLYSAAALVFGSWFAVKM
ALKKKSFSKDIGPWVYKTMKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVK
TLGIPAEVTDMKDYDPDDQLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSIQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAALQNVS
SEEELIESSSDEDESGLQDEKKSGSVVDMEDLGNIMNSAKKAMSKEEGRGDGQMVKLSKL
NGVKKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQF
RGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEI
RSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAW
NVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQ
YEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKT
PSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A4W6CX17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MLNFFLILLLFIIHVSASDSKVPRHEPSPGESYFMSIWHNRLYLYSAAALVFGSWFAVKM
ALKKKSFSKDIGPWVYKTMKKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVK
TLGIPAEVTDMKDYDPDDQLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRN
GSIQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAALQNVS
SEEELIESSSDEDESGLQDEKKSGSVVDMEDLGNIMNSAKKAMSKEEGRGDGQMVKLSKL
NGVKKIEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQF
RGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEI
RSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAW
NVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQ
YEIACEHEHSNCLLIAHTKFKVEGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKT
PSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A662QTS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nanohaloarchaeota archaeon|TrEMBL
MSNMRELFLKQHYGLAGAHSGCKICEWTKKSLRDEGVCYKEKFYGKIHGIRSHRCLQMSP
ALYYCTNRCVYCWRAVDKTAANCMDDVSIDEPSDIADGCIAAQRKLLSGFKGFSGTNIEK
WREAQDPVNVAISLAGEPTLYPKISELVSEFKRRGMSVFLVTNGQVPSALSGMDEPSQLY
LSLDGPTKDVYRMVDAPQLPDFWERLNESVDVMPSFSCKKAVRLTMVKGWNDNHFREYAR
LIERTNADFVEVKAYMWVGFSMYRLGKEAMPRHDEVREMARRLNEELGYEFRDEDERSRV
VLLSKK
>A0A7K4FEV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGETVEEEEQLLQIKPVISAQLKKAKYGIADHSTVGLCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPDQVAEPEQILTKLMAERKKLIN
GFYGDSRNDKQRLDESLLPAHYAISLSGEPTMYPKLPELIKYLNSLEATKSVFLVTNGQE
PDMIQKLQDQDALPTQLYLSTNAADYESFMRINKPKYDDSWERWNRTLNMLKDLNTRTVL
RITLIRDYNDQKESIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMDEVKKFS
EEIAKQSKIFSIMDESIVSRISILQNNERYIDRFIPTYANTI
>A0A7J9R6F2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilaceae archaeon|TrEMBL
MSCSGETVEEDQLIQIKPRVAQQLKKAKYGVSDHSTVGLCHWTKKSFKHEGSCYKHKFYG
ISTHSCMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPENVAEPQEIMTKLMEERRKLIMG
HYGDSRSDKQRLDESLKPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEP
DMIQKLQDENALPTQLYLSTNAADYESFLKINKPKYDDSWQRWNKTLEMLKDLDTRTVLR
ITLIRDYNDQREMIPAFAKMLEESSPHFVEIKSYMHVGRSTNRLEHENMLEMDEVKKFSQ
EIVNQSKIFSVMDESYVSRIVILQNNQRSIDRWISTYQNTN
>C8ZIH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse)|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNESTATEVEKAVNYPVTVDFTEVFKKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A0V1G2B8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LMPMLMISRLLCHVELDNTENIWKAYYKMFERILHVFFPSDMITFNLCESVLIIVGISTA
LIVILLYIIMKKKEKKEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDP
EGHLENEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGD
KAYRSTFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSS
KFSSVHDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIK
EMLTPTLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPS
LACANKCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEE
SSTVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSV
DAASKESLKEIDRPLTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCGDSKNS
KITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNVTIFKINGQWYTWID
YEKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A7R9FW91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema shepardi|TrEMBL
MITIFGVPFFGASFIPTLVAVATIYIAWSWFAKKQNGNKICSLEAIDAVTTDTLSRQVVE
NGKGPLISIGDKVGPRKIVAKARKKSCGGKGGKCCGSKKGKSKCLTIEGVIDRLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEERGPRGGLLTSNPHLHTDKPL
GGLTTHSAFQHRGRCPGDTARRHPERGFPREHLRARPGRCVSPQGIDDPLCQQHQREHNT
SPTSGQSLCVFVLPTHAEGKPPEAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQ
YADHFNEVGRSVDHWLHKLQAVRVAKLGAGDEDTAASRYGSIEADFDNWQNSLMGCVEKW
RAKSNCRCGGKSPPQEERIEEASSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNF
SSALRAARTRKESGESLGTREMITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGG
CYKHSFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALDAH
YKMINQFKGVPGVKPERLAEGFQAKHCALSLVGEPIMYPEINKFVKLLHQKEISSFLVTN
AQFPEAIREMSPVTQLYVSVDASTKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYR
LTLVKAWNVDELENYAKLVDIGKPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQK
LADLLPEYAIASEHEHSNCVLVAHKKFQVDGEWMTWIDYDKFHELVQKFYSTNGESSFTA
LDYMRKTPDWAVYGSSEQGFDPVETRWHRKSNTKDISGC
>F6H045|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vitis vinifera|TrEMBL
MRLFEAYNSHSARLTLLALLSASTLYCFYKSLRLKRHALLFPTTNPNSSSKGKLFFVSQT
GTSEILARRLLRLLTSCDLSFDLVHPKDYEPEDLSKETLVLIVASTWEDGNPPPDAGFFS
NWLAESADDFRVGSMLLSRCKFAVFGVGSRSYGAAFNAVARGFSKRMRKLGGLQVLPVEE
GDVDAGDLDEVFDVWSRKLISVLKGGSVENGVFDGSMAVVESDAETIDGSEEDYDDDDDA
DRENGAEGSIVDLEDIAGKGPSRKTKTMTTSSGTINGEKEMVTPVIRASLEKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WRWKMDDPLEIVNSAIDLHTKMIRQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEI
NSLIEELHRRRISTFLVTNAQFPEKIKELKPVTQLYVSVDAATKDSLKAIDRPLFGDFWE
RFVDSLKALREKQQRTVYRLTLVKGWNTEEIDAYFNLFSIGKPDFVEIKGVTYCGSSATS
KLTMENVPWHADVKAFSEALALKSKGEYEVACEHVHSCCVLLAKTDKFKVNNQWFTWIDY
EKFHDLVASGRPFNSKDYMAATPSWAVYGAEEGGFDPGQSRYRKERHHRPKTTD
>A0A2Z2MKU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus siculi|TrEMBL
MAITFKSNPNMPEEIANLFRRQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLIVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYIGDLVEEFHKRGFTTFIVTNGTVPERLEEMK
REDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWERIKETLRLMADADSRTVVRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGFSRQRLTINNMPRHEEIRAFAEELVKHLPGY
HLEDEYEPSRVVLIMRDDVDPHETGIEGRFIKH
>A0A7K9F7E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stercorarius parasiticus|TrEMBL
VSMDTWNFSYTCLVSLWLHRFYIYSVVAFGISIWIIIQFFTTKTKKKGEESNGNPAASEG
IKDKLVNGYATLQAKVVYVAGVKIFYGSQTGTAKKFATGLAEAVTSLNLPVEIISMGDYD
PDDCLAEETTSSNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
SRLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDHEHGASEHENTEAEEFFETSSEEEA
DAEEAGGTNAVIDVEDLGNVMSHMKKAKVLLLERMSHIAGLNLLFCHPVMEKSCGHPLLI
YFMFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILQEAIENHRNMIKQFKGVSGVKADRFEEAMTAKHCAL
SLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALSKKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFVEV
K
>A0A505IGU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus niger|TrEMBL
MPSPSGSSVREPIKGLAAGAKKFLENPEELKKGLGCIRLIVFSPCDLHSPKYRFSRLLRC
VPRTSSTPLSSSSPSAPRPLYLARLFESFRGHKGSQIPPLSHGSRLFFTIYLRWRDLETK
PKSKIATASSIPSSPRSHSPEKREKTISNSTEKDIGTDLKPSVVEKDASQKQAGPKRVTG
KKPLKVAGRRRGSDQEPAVSFIQPIIFFASLTANTERYAQVLLEELRAAARDRADPDNRE
RGLLPPQIHDLSYVDFDDYFISAPKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDET
HHDFRIDTAPLSGLAGYSVFGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGF
GDVKSDAESALKEWSRGLQDILGDIVENGGLGEGVPGSGDPLESDEEDLDDEGSESDKAN
GRKRNKNQSVVDLEDIKFSSDAASGSPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTK
QGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRH
GTNPVGTTWRWKVDDPELIFNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVG
EPIFYPHINRFLDMLHSEHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDR
PLHRDFWERFQRCLDILREKRHYQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIK
GVTYCGTSTSAGAGLTMQNVPFYEEVQQFVTSLNAELERRGLKYGIAAEHAHSCCALIAS
ERFHVNGKWHSRIDYDKFFQLLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERPT
ILPRFLIIGARPTCSVPNNAASNDAMYRPTDFTDFARGINNEPKFSVHGLRYKNPCFTVP
EDSVPPL
>A0A2J7QXM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cryptotermes secundus|TrEMBL
MLGIETRWFSFEVTEAATLCISHCPNMFTVLGIPLIGTLFLPTLLGVITFYIIWSLSTRR
KDSSCTGGLSSAAREPSDPMLAVNDLTSKPETKVFGNRAVSSPNLQSEDNSCTESDVYSV
TQIKVQYASNSRRKVFRSKAGDQCSQTVQVVSDLTKKNTRKKRCKGKPGCCSKKNGASTI
LEGTIETVKVFFGTQTGKSKIFSTVLAEGCEQRGLSSELVDLASADPEERLLEETSGNSL
CVFILPTYTEGKPPESAAWFYKWLQEASNDFRVEKELLKGMKFAVFGLGNSQYKAHFNEV
GKQVDGWLQELHAARLIKLGIGDEDTVASKHGSIEADFQNWNSQLWARVDKLRAACQCDA
TEQDQAESSCDSSSEGCYSDGDSSEQDSRGNGVLDLEELGSFSNSLLAARERKFEDNSPR
EMVTALLKESLTKQGYRIVGTHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDPPEQIMTEALENHYNMIRQFRGVPGVLPERFAE
GMDVKHCALSLVGEPIMYPEIGSFVRLLHERGISTFLVTNAQFPEALRDLSPVTQLYVSV
DASTKSSLRKIDRPLFKDFWERFIDSLKALSEKGQRTVYRLTLVKSWNADEIADYAKLVA
IGKPDFIEVKGVTYCGTSKASNLTMENVPWHGEVLSFVKKLGGLLPDYDIASEHEHSNCV
LLAHQKVNSLF
>A0A1Y5I385|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ostreococcus tauri|TrEMBL
MTLEYAVGRAGDAGTRARERAATALDSTSTTGKNLVVYMTTGGTSERFARALATRAAKAT
GERWTTMDGGDVDDPENTLGGERGITTVVFVVSTDTGGAAPKRGAWLARWARETAYDERA
GWMYLKNLRYAVFGCGNREYGDDFNRVGRALDAHLARMGAERLVRRRDGDEATGRMEAQF
EDWAEKVVKRLASSSRASDVVAKGGLFEESTSTDDVEGGCGSQDEDALSIAGSEDGQDME
DIGENEGGEPKEMVTPALRGALTKQGYKILGSHSGVKICRWTKAMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCTFCWRHHTNPVGKSWRWKMDEPLELVEQAISEHCKMVKQMKG
VPGVLPEKLAEGMEPKHCALSLVGEPIMYPEIAKFVSELHSRKISTFLVTNAQFPEAIVD
LPPITQLYVSVDAATPETLKAVDRPLFADYWDRFVNSLKSLKMKQQRTVYRLTLVAGYNM
EDIAEYAKLIDLGQPDFIEIKGVTFCGSSDTSSLTMKNVPYHKDVCKFGEAIVDMRRREN
GEEEYGLACEHAHSCCILLARTDKYKIDNEWYTWINYDKFQHLVVKGEKFTAADYIERTP
KWATYGAVEAGFDPEQTRHIKIRNHPGKDKTAPLIQGEA
>M9SDQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomethylophilus alvus (strain Mx1201)|TrEMBL
MDEEYRQTLIRQHYRIYRDHAAVKLCGWMKQSLLHQRTCYKQDFYGIQTHRCLQMTPALN
ECTHLCPFCWRVEGKDFEVKEWAEPKEMLDALIDYQRLLISGFKGDERCDPVMFQEAMNP
TQVACSLAGEPTIYPYLSEFFKECHSRGMTTFLVTNGTMPERIEALDTLPRQIYVTVAAP
DKATYAKACRPKIKDGWERLMRTLELFPSLETRTVVRHTLVQGVNLMDPESYARLDRVAD
PDLIEPKGYVFVGGSRQRLTVDGMPAFETIKDFSKRIADILGMDVLREKADSRVVLLGHE
GMELDVRKAWEKGLPPSPRMDRLTADMCQ
>A0A3P8ZQS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
LLIREPGNYGFANELEEEVKTLGIAAKVIDMKDYDPDDRLADECSTKSICVFLLATYTDG
QPTENAKWFCKWLEEASTDFRYGNNYLKGLRYAVFGLGNSVYDSHFNTVSKNVDKWLWKL
SGVRVLSRGDGDCNVVKSRHGSLHSDFLVWKTKFLSRLQTMVAGPKACRGKCKTGGSCNN
RKKPQKTDDEQAAPEQLSSETSHHATSISMLLPCNTMQPCEARVTNTENARLKIQQKSHL
SKCLCISWTESVIDRLLKVQICDHITFSTFCSTGYKLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEKILLEAVENHQ
NMIRQFRGVPGVRLERYQEGLKVKHCALSLVGEPIMYPEINAFLCLLHSQRISSFLVTNA
QFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWTRFLDSLKALGEKRQRTVYRL
TLVKAWNVDELKSYSELISLGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVQQL
VDMLPQYQIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYEESGGSQTFSAM
DYMAKTPMWALFGASERGFDPTDTRYQRRHKTKDISGC
>A0A7L3BRC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pelecanoides urinatrix|TrEMBL
LDVSMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTRKKVTEHKSNGNLAS
SEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMG
DYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCRWLEEAANDFRFGKTYLKGLRY
AVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSVEADFEAWKA
KFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEREASEYENTEAEELFETSSE
EEADAEEAGGTNSVIDVEDLGNIMSHMKKAKSSIETVMFNNFVYQLIRFGHQLLQVKIDG
LISFLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDDLKAYADLISLGKPDFI
EVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLIAHKKF
KIKGEWCTWINYDRFQALVEEHERSGGSKTFTAADYAARTPRWALFGSRERGFDPLDVRY
QRKNKARDISGC
>A0A3M6WJK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDMEKILQLPQELLFLWHAHRAEVLLSAGLIFAILRLAQRGLDPTGTKKSKSAASQEAQV
IEKIQPIIFYYTLGGSTKVYAESVAQDLTTSSPSSILEPQLHDLADTEYDDFFLSIPKAE
KTAHFYLLLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSE
AEGFCTQAVDADKWMARLTGRKRGFPLGFGDVSKKDEADVMLKEWTEGVSSIMKDLAEGK
GLGEGVPGSGEPIESADEASEDEDETPTPRKSKRKPAKRSRTDDLEDLKAPIPVDFTTSK
PTSTTQPPPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFY
GIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMM
RGVPGVRAERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRERISSFLVCNAQHPDQL
EALGPVTQLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVK
GFNIEEEAEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALE
KALANRGLDYGIGAEHAHSCCILLADRERFYRIPEAEKGNPAAEKKWHTLIDYPRFFDCL
ESGKPFSPEDYVGPPTPEWALWGNGGFDPRDERVDRKGRPKEVKEVKVQEVQ
>A0A0M8MWR0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Escovopsis weberi|TrEMBL
MNEAPEISMEDILQTSKAVELRKGGDIVKTLAICEEQLAQMPLAKQPDHLNATLLPYQLQ
GLAWMQSKEHPKFSEDNPDAVIQLWKRDRQGRYRNLASDFLCLTAPKLFSGGILADDMGL
GKTIQIISLILMGGPGTTLIAAPVGVMSNWEQQIRRHVKEECQLKVLIYHGANRSRREEL
FNYDVVITSYGTLNSDDVFKTCKIEATSRWVLTGTPIINSVKDLQSLLKFLHITGGIEQP
EVFNIAITRQLASQELSGEALLQALMQDICLRRKKEMNFVDLKIPKKTEYIHRITFHPDE
KIKYNALLSEARGMLKSFQDRSQHDQNGHFQSVLERLLRLRQTERIDNLMKLLEDQAVIP
LTEKNCALLQEALRLFIETQDDCAICFDPPTGPQKCPMCRNPLTEDMLLEPGPEGAADNR
ILDPNTQSSKTEATIHIIQATLKRQGFKLVIFSQGTSFLDIVQKRLEAAGIKHCRIDGSM
NASKRDLAVDALDNDPDTRVMLASLAVCSVGLNLVSADTVILSDSWWAPAIEDQASAPSH
FAVDNLPRAPPAVLRLERQVCPIACLDKMGLLDRLWAGATASDAVAIWHAHRTSVIIGAL
VILGATRLFLHSTEEREPLKIIPKLYSDAKEAPAEAADKKPIAEPAAKPAPRSDGPRRVQ
GGLKKKRSPEDQEGNANGEVQAQGPTKVLVFFSSITTKTETIARQYIQTIEAFLTRSEKE
KEKEGGPRFLKPELYDLAEIDFEDFFVSPPKSPEDARLFYLFLIPSYNIDTINDTLLQHL
EETHHDFRIDTAPLSTLRGYSVFGFGDKEGWPNEDEGFCFQAKDLDKWMSKLTGRKRAYP
IGMGDMKGDHAERFAEWTRGVEEVIVHVATTGSLGEGVTGSGEAEESDAEDVAEDGDGEV
VLDDEASGSKGSGSTVLVDIEDIGKMVRTDATDKAPLAVDFTSYGSSTKPRKAPASAVKE
MVAKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTP
SLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYN
EALRIRHCALSLVGEPIFYPYINEFLAMLHGERISSFLVCNAQHPDQLAALKAVTQLYVS
IDASNRDSLRKIDRPLHRDFWERFLRCLDILREKRFRHRTVYRLTLVKGFNVEDEVEGYA
RLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFVKALARRLQEMDLGYGI
AAEHAHSCCVLLASERFRVDGKWHTHIDYQRFFELLEERGADGDWTPEDYMGPPTPEWAL
WGNGGFDPRDERVDRKGRKMEAVVVREAPE
>G2YLZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryotinia fuckeliana (strain T4)|TrEMBL
MAYDSWISRPVWSFGIDDVVALWHLYRIPIILTTATILILVRITLRPRALREKLSASPLP
TSPILSAAKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTANSFVESLTRDLSGRANEQRIQFLESQLLDLSYIDYDDYFINPPKGESGTSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVDDVEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTASEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTG
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASNRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDAGEDKVAEDSTKDDLAF
>A0A3M7DDJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MPIAPGECTAAHVATNIHPPPMLDMEKILQLPEELLFLWHTHRAEVLLSAGLLFALLRLA
VHWRTRKSKEVLTPPVLTPVDEKPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVT
GTKKSKSAASQEAQVIEKIQPIIFYYTLGGSTKVYAESVAQDLTTSSPSPILEPQSHDLA
DTEYDDFFLSIPKAEKTAHFYLLLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAG
YSVFGLGDKHEWPSEAEGFCTQAVDADKWMARLTGRKRGFPLGFGDVSKKDEADVMLKEW
TEGVSSIMKDLAEGKGLGEGVPGSGEPIESADEASEDEDETPAPRKSKRKPAKRSKTDDL
EDLKAPIPVDFTTSKPTSTTQPPPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPV
FQGMKEGHYKKIKMMRGVPGVRAERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRER
ISSFLVCNAQHPDQLEALGPVTQLYVSIDAIKGFNIEEEAEGYANLVETARPGFVEVKGV
TYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALAKRGLDYGIGAEHAHSCCILLADRE
RFYRIPEAEKDNPAAEKKWHTLIDYPRFFDCLESGRPFSPEDYVGPPTPEWALWGNGGFD
PRDERVDRKGRPKEQPKVQEVQE
>A0A8H4TA11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sarcochroum|TrEMBL
MDWANYSSPSRLDSFVDELVDVWHIHRTPILLSVFTVLVAVRLYFLLNGQKTEVVTFKNV
YEEPAKPKVVVEEKTPLIETIDEKKNAKSQGPRRIKGGLARKPSKNKEEKDLTRPVVPLV
FFSSITTKTSKIAQAYVEDLGGRLEDLSKQSGRQFLKPELRDLTEIDFDDYFLTPYKAHG
DADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTGPLSGLLGYSVFGFGDKENWPTE
EEGFCFQAKQVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWTKGVEEVLEHVARTGNL
GEGLPGSGAADESDVEDIAEDEDDGEVILEDDDTKKKTKGGRDLDDVEDLGRMIRKDDGS
TTQKAPLAVDFTTYSSSTKKTVPQGPKEMVSKESPTYAALTKQGYAIVGSHSGVKTCRWT
KSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEL
IFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPYINEFLGMLHAE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLDILR
EKRFRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKKF
FELLEERGPDGDWTPEDYMGEATPEWATFGNGGFNPEDDRVDRKGRKIEAS
>A0A6G1P3W0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium dahliae VDG1|TrEMBL
MSGSRDGWALMPLLNDLHDAWQQVRVPVLLVVALGLVGLRIYLQVTGEKPEQLKALPKKL
AADETVAEKAALARDAKAEKPPVVVVAEASGAPRAPKTTSGPRRVKGGVVRRRSSDDNSI
TATTPKIAKQFAEDLGRDMHKAAPETRCTFEAPELLDLAEVDFDDYFVTPPPAKGDVELL
YLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSVFGFGDREGWPNEQEGFC
FQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIIEILGQLARTGGLGEGMP
GSGAPVESDEEDADEEDDDETLVEDGEAKPEKLKNSKNLEDVEDLGRIMKDSRPDSVPAK
GKGAPIAVDFTTYGKTAAKKAAPAPPTVKEMVPRNSPTYASLTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPP
EDIFNGVKAGHYQKIKVLRGMAGVRADRYAEALRIRHCALSLVGEPIFYPHINEFLAMLH
AERISSFLVCNAQHPDQLASLRAVTQLYVSIDAADKESLRRIDRPLHRDFWERFMRCLDI
LRERRLKQRTVYRLTLVKGFNVDDEVDGYAALVERGLPCFIEVKGVTYCGTSTASNAGLS
MSNVPWYWEGLRYGIAAEHAHSCCILLASDRFRVDGKWHTTIDYQRFFELLEERGPDGDW
RAEDYMGPATPEWATWGNGGFDPRDDRVDRKGRKIEAK
>G8ZVX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Torulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866)|TrEMBL
MSFNRGSALAVLLCIGIYLWLGGRLSVALAGLVFCGIFYKEFNGTSAEVVGLNEKTVVAE
PTKKKKSCCGGKGGAGCCSSKGGEKKSGCCCGSKKKTADIEEYVPVAPKEDAYPEEIDFT
DAFKPVNKSKKLGANARPPKVFSKPELKNASKHDEDLVKSAMTVSNSTLLSSQTYVFYSS
LQGAAQRSAEKVHDILAKTEGLQLPPILMNLDELDDIDEYFVSIPSDNALYFLILPSYDT
DCPLDYFLQTLEENFNDFRVDKFPLRKLVGYSILGIGDRESWPEKFCYQARKADHWIARL
GGRRIFPVGEVCMKTGGDSEIADWANLLSDTLKDDEPILYEYDETVDDEDEADDQLGDLE
DIGNEGTTVESEMKQMVAKDSPTFKKLTKQGYTIVGSHSGVKICRWTKSDLRGTGSCYKH
SLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDPPEYILENALQGHYSKI
KQMRGVPGVVMDRFAKAFQVRHCALSLVGEPIMYPYINKFVELLHEKGISSFLVCNAQHP
EALESIGKVTQLYVSIDASTKQELKKVDRPLYKDFWERMLTCLDTLRTTQSHQRTVFRLT
LVKGFNMGDLSSYADLVQRGHPSFIEVKGATFAGSSDGNGNPLTMQNIPFYEECTNFVKE
FAAELQRRGLGYDVAAEHAHSNCILIANTKFKINNEWHTHINFDRFFELLNSGKDFDAMD
YTAKTPEWALFGNGGFAPGDTRVYRKGKKKSQQVVDTKQNI
>A0A7L4F6P9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alopecoenas beccarii|TrEMBL
DVSMDTWNFIYTSLVFLWLHRFYVYSVVAVGISVWMTIQFFTTQTRKKVREDGTSSEGIE
DKLVNGSATLKAKELHVAGVKIFYGSQTGTAKRFAQGLAEAIISLRLPVEVISMGDYDPD
DCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAAHDFRFGKTYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSASRIMTRVEGDCNVAQSKHGSIEADFEAWKAKFLGR
LQVLCRGEKKPCSGKCKKGKCKPPGKQSKESSDPEHGASEYENTEAEELFETSSEEEADV
EEAGGSNSVVDVEDLGNIVSHMKKAKTELSIRFATAVFLHGESCNIPSHVLTPAFSYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEMILQEALENHRNMIKQFKGVSGVRADRLAEAMTAKHCALSLVGEPIMYP
EINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFRDF
WQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESS
ASNLTMANVPWHEEVVRFVQDLAGLVPDYEIACEHQHSNCLLIAHKKFKVDGDWFTWIDY
GRFQELVREHERSGGAETFTAADYAARTPDWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A0V1I8I8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella zimbabwensis|TrEMBL
MWKAYYNMFERILHAFCPSDMITFNLCESVLIIVGISTALIVLLLYIIMKKKEKEEHRED
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVFDLQHYDPEGHLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYRNTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEDCSSKFSSLHDNKRVSVWRDENENS
SDAEDAENNANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQGYHLVGTHSGVKICRWTKSM
LRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPADKILF
DSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMHSLNIS
TFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILRDKK
QRTVYRLTLVNRYNMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKNSKITMANVPWHADV
VDFVQQLVFQLDDYDIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAERFKKDGI
SFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKIW
>A0A1Q7CW98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_38_12|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLIEERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRILVLQNQKRFMDRWIAAYANTN
>A0A1V6IP25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon ADurb.Bin023|TrEMBL
MDSYPDNLYITLPAPTKEIYEHICNPQIKDGWSKLNESLELIQKIKTKRRILRLTLVKDF
NMKGVEEYSKLIEKTNPDYIEAKAYMFVGYSRKRLEVENMPMFDDVLEFCKELEEKTGYK
SIDFAKDSRVILLSRN
>A0A0F8V1R6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus ochraceoroseus|TrEMBL
MAESSTAEEGVLAFWHSFRLPILVALTTVIVIIRLRRKTQARRLKAATASSVPPSPRSSA
PEKTIEKHEVPAVSEKKELKGPDRTAVTGKPAPGPKRVSGRKPQKVAGRRADTTDQEPAL
TFLQPIIFYASLTGNTERYAQLFLEDLRAAAQSQSDSENRERGLLPPQMHDLAYVDFDDY
FTTAPKPPSTSPGTRYIYCFLIPSYNIDTILNTFLAHLDETHHDFRIDTGSLSTLAGFTV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTDKKRAYPLGFGDVKSDAESALKEWSRGLQ
EILGDIVEHGGLGEGVPGSGDPLESDEEDLDDEETDDAKQKARPRRKPRAVVDLEDIKMG
SNSQAGSGSPIPVDFTTSGNPAVQSIQPTEKEMVPTTSPTYAALTKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKFSFYGIRSHLFGTTWRWKVDSPELIFNGVKEGHYKKIKMMRGVP
GVRAERFAEAMRIRHCALSLVGEPIFYPHINGFLDLLHSEHISSFLVCNAQHPDQLETLH
RVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHIQRTVFRLTLVKGFNV
DDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPFYEEVAQFVVSLNKELE
RRGLDYGIAAEHAHSCCVLIASRRFHVDGKWHSRIDYPRFFELLEQEKADGTSFRPEDYM
KETEEWALWGNGGFDPNDERVHKRGKKAALQRALEA
>A0A7J9BCI8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium gossypioides|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRRLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPQTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDYDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFILGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHNLVALGRPFD
SGDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A8C2Z9D6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyclopterus lumpus|TrEMBL
MLSVFVVVTLCISRVSASETKVSQNALSPSESYLMSVWHNRLYLYSAAALVFGIWFSVKV
ALKKNKFFKDSKAQKSSDHSDRDAVAAHVSGVKIFYGSQTGTAKGFAEELSEEVKTLGVP
AKVIDIRDYDPDDQLADECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKT
YLKGLPYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSAVRIMTRGEGDCDVVKSRHGSIQA
DFLAWKVKFLIRLQALVKGEKKSYSGNCKTKGSCKNPKKDGQEEEEETTALQNSSEDELV
ESSSDEEESGLQDEEKSGSVVDMEDLGNIMSSAKRAKSKEEAGADQMVKISKVNAVRKID
NEGERREMITPALRKALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILHEAMEKHQGMIRQFRGVPGVQ
PERYEEGLAVKHCALSLVGEPIMYPEINAFICLLHSHRISSFLVTNAQFPQEIRNLVPVT
QLYVSVDASTRDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLS
YSELIALGQPDFIEVKGVTYCGESAASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEH
EHSNCLLIAHTKFKVDGEWWTWIDYERFQDLVQVQGESGGQRGFSALDYMAKTPSWALFG
ANEQGFDPTDTRFQRRNKTKDISGC
>A0A6A6TH24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lophiostoma macrostomum CBS 122681|TrEMBL
MRTMPSPTTLGQLPDELIYLWHTHRVPVLLSAVSLIALVRLAIYLRGRRPKKTVLSVPGS
PNEKVVVDLKPEWLPENTTLDPSVVNIDGPAEDTVPALAPLVKSKRGPRTIKGKKMKRGP
KATPVFDHKNDVVQPLVFFQSLSGTTERFASQFSQAFASWVSEAQDAASVLEPKIHDISY
TEYDDYFISPPKSDAKVKHFYIILLPSYNIDTVLSTFLENLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPSEEEGFCSQAREVDKWMARLTGKKRAYPMGVGDVKGNAEGQLEEWRL
GLQEALTDIARGKGLGEGVPGSGDPAESDEEDEDTASDSGRDTPTSKMMKPKKTTRVDDL
EDLGTMVDLSASASAIPIDFTNYKSKPILKASPAAPKEMVPVTSPTYASLTKQGYTIIGS
HSGVKICRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTT
WRWITDAPEVIYDGITNAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHI
NELVNIMHANRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFCACLDILRNRRFEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTS
AAGSAGLTMQNVPFYEEVAEFVRALEVELKSRGLTYGIAAEHAHSCCILLADESRFKREG
RWATRIEYERFFELFEGKVQGTRVEKGDGGKTKVVGWRPEDYIGAETPEWALWGNGGFDP
RDERHFRKGKGPKVEEGKEKEGEAEMGVDAKKRDVAVVEI
>A1DNK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)|TrEMBL
MAEHSTAEGLTKRDPPTNIMLTDCSFIGLLAFWHSYRLLFLVALSTVFVGLQFYRKLQSR
TKTTASSSVPPSPRSPSPEKTEKGVSLESSNKATTQKAERQPAVANGSAKATSGPKRVTG
KKPLKVAGRQGQTEDAEPLAFIQPIIFYASLTGNTERYAKILLEELRAAAQKRADLQDRE
RGLLPPQIHDLSYIDLDDYFTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTFLDHLNET
HNDFRIDTGPLSSLAGYSVFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGL
GDVKSDAESSLKEWSQGLQDILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQN
VMDLEDIKFGGDQNAAGSPIPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWKVDSPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLDMLHGEHISSFLVCNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFW
ERFQRCLDILREKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGT
STTAGVGLTMQNVPFYEEVAQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFHVNG
KWHTRIDYDRFFELLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKH
MQITAEP
>A0A0D2QC70|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium raimondii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAKTNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIVRFLESSQRET
STDCISLDTCERMEYRRCRCLF
>A0A7J3VQG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaerales archaeon|TrEMBL
MSCADEHVQDLIQIKPIIARQLRSAKYGVYNHSTVELCHWTKKSFMDEGTCYKHRFYGID
THRCMEFSPAGMFCENRCIYCWRPMEFYEHIEMPSNAVDEPQAIIDNLMHERFRLMSGYF
GNADANKAKLREAMRPTHYAISLSGEPTMYPKLPELIRHLKSLKDTRSIFLVTNGQEPDM
LYRLEEEDALPTQIYLSTNAPNKRLFYLINKPRLRDAWERWLKSLEFLASTKARTVARIT
LIRSYNYGLDTAREFAEILRIGNPHFIEVKSYMHVGNSINRLSADEMLSMDEVLAFTEAL
EYHLDGYALYDWSIPSRVAVLQNVKRYVDPIIR
>C3MPQ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>A0A7D6BCJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Fermentimicrarchaeum limneticum|TrEMBL
MKQELHAMKQGLKAHVNRVRMSLGVGMGYLPDALSTQLMKQHYHLVGKHSAVKACKWLRE
SILGRRTCYKNTFYGIDSWRCVQCSPVIGCNLCCRFCWRISPEDIGIKWDEMSEPVWDEP
ELLVEGFLKEQRRIVSGYKGNPKADRKRWEEANRPAHVAISLIGEITMYPFLSELIDKFH
RAGMSTFVVTNGTLPEKIENLSTLPTQLYMSLEAPDEETYRKTCRPKIKIAWEGVNRTLE
LFPSIKTRKVLRLTLVDGLNMLNPEGYAKLILKAEPDYVEPKSFVFVGGSRYNRGLELGN
MPKHEEIREFAGKLSKETGYMVSDERADSRVVLLCKDREAEKKRFIQKK
>A0A835NNR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lamprotornis superbus|TrEMBL
MDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQYTTTRTKRKGEKSHGNLSSPKGAA
DKLGNGCAPPQALEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPE
DGLVEETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDKWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHRTSEHENTEAEELFETSSEEEAEG
TDSVVDVEDLGNIMGHMKKAKREQELQEGAAGAGRKEEAERREMITPALREALTKQGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWSKQEHGQ
DEGLCSQHYSTEHFPVSLPNALIQDFLAAAWMWNRLNQGNPASQQPDDSECCSADFPDGY
NLNARKQLPRALSSQLLCLGCCSLHVAVRGIFPPSLPHPIPADPGTGSQLPNPAARPIFV
QCVRLRWNCRPWWLGRINRAAPEQQVPSLLLQTCEILVLLCCWQNVLCWAPRAALHAALQ
IRLLGFFLLDLFFEDFDICRFCQCFQLHNHQALPRWLKERPRSLFIFSSSLWQECCSSAA
FPGNWIHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKARLEEALAVKHCALSLVG
EPIMYPHINGFIRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDR
PLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISIGKPDFIEVKGVT
YCGESSASSLTMANVPWHGEFHVDGEWRTWIDYGRFQELVREHEQSGGSRTFTAAEYTAR
TPPWALFGAKERGFDPLDVRFQRKNKARDISGTPFQADTNFGSIHLDYPDMKTLITFLSQ
DKSELVQQQWVGGSAGVSSVGNAWSGMWAQRVPWTPVQGEPESKTFHIPKEKCQGISAPQ
GWIRAGILNTGAISCKNSIPKKPKLRNGVTAPLWIPAAASGTSPSVFQPHDFGNEV
>A0A0X1KKS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus guaymasensis DSM 11113|TrEMBL
MAIVVKANPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEGMM
KEDKLPSQLYVSLTAPDIETYNRVNVPMIPDGWDRIKETLKLMRDVQTRTVIRLTLVKGE
NMHNPEGYAELIKLANPMFVEAKAYMFVGFSRNRLTINNMPNHGEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPSGRGLNGRFIAD
>A0A257MAR3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. ASP1-1|TrEMBL
MNITSTYLSPSNPSLHTMPSQEQPTDTLARQGYHLVGGGAVKPCLWLNRAMRGGDQCYKH
HFYGISSHRCVQMTPTLQCNHLCLHCWRPIDHPQPEKEPLEPAKLLEGILSGQRKFLSGY
GGAKTTDPARLAEAREPKHIALSLMGEPTLYPYLKELLDLIGRRGMTAFLVSNATRPEVL
AELRPTQLYLSINAPDEVMYRRACRPAANLWPKILQSLDELRDHRCRSVIRLTLARGLNM
ERPEDYARLIERAEPDFVEVKAYMHLGRSRDRLTREAMPSHAEILEFAAALGRALGYEPE
ADVPLSRVALLASGRVKRLIDL
>A0A7J7HUQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Camellia sinensis|TrEMBL
MSSPSSSSSSAAAHLTLLALLSATTFYCFYKSRRLKKLSSSQTLHPLNLSPPPPPKPKLF
FISHTGTSKTLAHRLFDLLTSNDLAFDLVDPNHYEPEDLHRETLVLIVASTWEHGKPPPS
GGFLANWLAESAEDFRVGSLLLSKCRFAVFGVGSKAYGETFNAVAREFSKRMRALGAAEL
LAVGEGDVDGGELDEVFDGWSKKLIEVLKGGFLENGVRGWNESDSEMISSDDDDDDDDGE
ENGEESGIVDLEDIAGKAPSRKSKTVIQSNGKLNGEKEMVTPVIRASLEKQFPDKIRMLK
PVTQLYVSVDAATKDSLKAIDRPLFGDFWERFVDSLKALREKQQRTVYRLTLVKGWNTED
IDAYSSLFAIGNPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKAFSEALAQKSEGDYEV
ACEHAHSCCILLAKVDKFKVNGQWFTWIDYEKFHDLVASGKPFDSNDYMAASPSWAVYGA
EEGGFDPGQSRYRKERHHKSSH
>A0A836LLX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania sp. Ghana 2012 LV757|TrEMBL
MIGCALQLLVSAGLTFVAFLLFNCLADSAHARGNVAASDTDAAGNTDVFSRQVRAELEQL
GVASAPPTAESVQSAPPAAEKTPSPAPTAVAAEAVPTAAAAAEILIAYATQSQNSLALAH
KLFSLITTQIHTSPMRTTEAAVCPLVRVMEMREEDSNGSGATDVASGGRVGSKNVCRVDT
LLEENRYALIIFIVSTYTDGLAPPRSRVFETMLRDAFEDHRVPRNALGRKRFAVFGLGDF
AYGEARFNAFAKNLHEWCRGLGAPPFVVPPVYATEAKAQSLFRIFSTALLKWVSRATFHS
DGTVTVQKKSEVAVTGSAAAGATGVRSRRPRSVAATSTANASMTSAAAGEALGNEGLSCA
CQQSSGQPCGNGAGAGGEESCGCCETEPARNGVAASKSDDDDDDANAEKDSMDDVEDLVW
DGTDDADFDINKDPNELPELIYPKLRQSLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCY
KHTFYNINSSQCMEMTPSLACANKCIFCWRHHTNPVSRHFRWKQDPPELLIAQGMAGHYQ
MIKQMRGVPGVTPERLAAAMQIRHCALSLVGEPIMYPQINRFCALLHQQHISSFMVTNAQ
FPEQLRDLQPVVQLYLSIDAPTPEELKRIDRPLFEDYWDRCLSCVKELAKKRQRTVFRLT
LVKQYNTDNVKAYADLVEMGQPDFIEVKGVTYCGTSPSSTLNMKDNVPRHDQVMGFCKAL
CAEMASRYPHYRTPQMDGDEEGGDDVIVIPAEERDRPYHVACEHEHSCCVLIALDKFFFE
GRWHTWIDYERFYDLVESGRTDFTSLDYAAVTPAWATCNSKEKGFDPEQTRVVRKNGRPT
IVTASC
>O28023|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)|TrEMBL
MMNEKLLSELKGYQIVGKHSAVKTCLWLKKSLKDEGVCYKQKFYGISCHRCLQMTPALMC
NQNCLYCWRPLELLKGFRGWDEPEFIVEESIRAQHRLLSGFHGTEGVNRKKLEEAYEPNQ
VAISLIGEPTLYPMLPELIEEYKKRGFTTFLVTNGTNPDMLEKVKPTQLYLSLTAFDEDS
HLVLNRPGKSNWERVLRSLEVMRDSGSRTVIRLTLIRGYNMDEEAIRKYSELIEMAEPDF
IEAKAYMYLGYSRLRLRWGNMPEHADIVEFSRKLADSTGYEVKRESEPSRVVLLERVK
>A0A5N6I3V1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus pseudonomiae|TrEMBL
MAEPFLTEGLVTLWHSYRLPILIAIASVAIILQAYRRFQPKSKAVTASSIPPSPRSQTPE
KFDQIRTGERETPAVAEKSAPKPAVRNDPAPKVVSGPKRVSGKKPLKVAGRRREDQEPPL
SFIQPIIFFASLTTTTERYAQILLEDLRTAAKERADPENRERGLLPPQIYDLSYIDFDDY
FTTAPKPPPTSPGTRYVYCLLIPTYNIDTVLNTFLSHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAESAFKEWSRGLQ
DIFFDILDNGGLGEGVPGSGDPLESDEEDLDDEENDGKGTKRRNGQDVVDLEDIKMGSDG
QTGSGPVPVDFTTVGKSAAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELI
FQGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLNMLHSER
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVVGYANLVEKALPCFIEIKGVTFCGTSTSAGVGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCALLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVYTKGSKKGLHLAAT
>A0A6J8EU37|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilus coruscus|TrEMBL
MEEADKRFIGERLKLNIAIQLKHRNRQTLNRNYSAILTTQYNNLFFVQPESKLVPATQLY
VSINASTKESLKKIDRPLFKDFWERLIDSFKALSAKRQRTGVTYCGESKASSLTMQNVPW
HEEVVHFVKQLTDRLDEYEIASEHEHSNCILIANTKFKVDDEWWTWIDYPKFHQLVKGFN
ESQKTFSAEDYMAKTPPWAVFGAKEQGFDPVKTRFFRKKAERYWRMLIFAHVI
>F6TQM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Equus caballus|TrEMBL
MDPSLDTWDFSPLISLWIHRFYIYWGFAFGISLWICFQIVIRKQDKTSQEKSLSKATRDL
VTNGYISLQEKEVFVSGVKIFYGSQTGTAKGFATILAEAVTCLGLPVAIINLKEYDPDDH
LVEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEASIDFRFGQTYLKGMRYAVFGLGN
SAYASHFNKIGKNVDKWLWMLGAHRVMTRGEGDCNVVKSKHGSIEGDFRAWKTKFISRLR
ALSKGEKKSCGGNCKKGRCKSSQHGSEEMEPGSPAQDGLHQRDTEEEEPFASTSEEESSI
EDHQSLSSVVDVEDLGKIMNHVKKEKREKEQQEEKTSLFRNTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQSMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIKNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVHELVDLIPNYEIACEHEHSNCLLIAHKKFKI
DREWWTWINYNRFQELIQEYEDSGGSKTFSAEDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A6J8CYE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mytilus coruscus|TrEMBL
MELHANSRQKITKKRKIKIFYGTQTGNAKMLADNLYREATERGHEAEVIDLKTYDPEDNL
VTEGENGVWIVLFVSTYTDGTPPEGSEWFCKWLEESSTDFRIPKALLKDLHYAVFGLGNS
LYTENYNAVGKKVDRFLKELSAKPILPVGLGDENVAESLKGGMEKDFTAWKKEFWKKSKK
VKDDDTAVKDTCGTGKKTCDGKCKCKEDGGKCSSEEEEEEGEDLYETTTEEEDNAEELLN
EDRDGSSLQTTNGVVDLEDLGKVMQTMKKAKVRRKKEESAQSTGEPREMVTPMLKKALEK
QGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHAFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDDPNTVFQGALDNHVGLIKQFKGVPGVKAERFAEGLEPQHCALSLVG
EPIMYPEINRFIELLHGKGISSFLVTNAQFPDAISNLVPVTQLYVSIDASTKESLKKIDR
PLFKDFWERFIDSLKALSAKRQRTVYRLTLVKAWNTDELDNYADLVSLGKPDFIEIKGVT
YCGESKASSLTMQNVPWHEEVVHFVKQLTDRLDGYEIASEHEHSNCILIANTKFKVDGEW
WTWIDYPKFHQLVKDFNQSQKTFSAEDYMAKTPSWAVFGAKEQGFDPVETRFFRKKQKDI
GGC
>A0A7K6W3P5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Steatornis caripensis|TrEMBL
LDASMDTWNFFYTCLVSLWLYRLYIYSVIAFGISVWFAIRFTTAKTKKKVNKCVTASEEI
EDKLLNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVTSLNLPVEVISMGDYDP
DDCLAEETTSRNICVFLVATYTDGQPTESATWFCKWLEEAANDFRFGKMYLKGLRYAVFG
LGNSAYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEVWKTKFLS
RLQVLCRGEKKPCSGKCKTGKCKSPGKQSKETSDHEHGASEYENTEAEELFETSSEEEAD
AEEARGANSVIDVEDLGDIVSRVKKAKVLLSQRVHVLCWYLVMGSRVAGGVAMHCCKSFL
KTDDLIYLLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMT
AKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDAS
TKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGK
PDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIA
HEKFKIDGEWCTWINYDRFQELVREHERSGGSRTFTAADYAARTPRWALFGSRERGFDPL
DVRYQRKNKVRDVSGC
>A0A1Q7PNM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_2_39_4|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLIEERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRIVVLQNQKRFMDRWIAAYANTN
>A0A3Q3SG95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mastacembelus armatus|TrEMBL
MDFSKPLAAMRSFFVVVLLVVSRVSTSETKASQNEPGPSERAFMSIWHNRLYLYSAAALV
FGLWFSLKMARKKKSFSKDVSPSVSKAVKNNKSSDRDAVVNVSDVKIFYGSQTGTAKGFA
KQLAEEVEALGIPAQVIDMKDYDPDDQLADECSGKSVCVFLVATYTDGQPTESAEWFCKW
LEEASTDFRYGKTYLKGLRYAVFGLGNSVYIGHYNTVGKNVDKWLWMLSGMRIMTRGEGD
CNVVKSRNGSVQADFQAWKAKFLKRLQALAKGEKKRCSGNCKSEGSCKDKRKDGQRKEQE
RAALQNNSSEEDLIGSSSDEDESGLQDDKKVVDVEDLGSIMNSVMKAKSREDVRADGQTV
KLSKLNGVTKIEDEGERKEMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCY
KHTFYGIESHQCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQN
MIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSHHISSFLVTNAQ
FPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLT
LVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLA
DMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQTFSALD
YIAKTPNWALFGAYEQGFDPADTRFHRRNKTKDISGC
>N1JAG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blumeria graminis f. sp. hordei (strain DH14)|TrEMBL
MPYNDTEGLRHIWLTRIENAVGNWHNHRISLLLSGFTLLIILKLLFKLQQLRQNSINTKI
PQNTSPPEKETHYERKSAGAKGPRRIIGEIKKRKPVQEQDIRSRSVQILVFYSSLTGTTE
QTANLFTCELAQTCRNLGAPNHATFHEPKLLDLSTIDFDEYFLNIPKGGADCQYFYLLIL
PTYNIDTILDSFIEHLRETHHDFRINTSPLSGLLGYSVFGFGDIEGWPTEKDGFCSQARD
TDKWMAKLTGGKRAFPLGMGDIKKDGRGRLDDWKKGVEDVLSYMVKTGNLGEGVLGSGDA
VESDDDSDEDQILDQRNPTQKRSLIQSSSTLNDLEDINIKPASDKTSLSLQETDFTTKGN
KLNTMIKEMVPKNSPTYAALTKQGYSIIGSHSGVKICRWTKSALRGRGSCYKYSFYGIAS
HQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPELIFEGAKMGHYQKIKMMRGVP
GVRAERFTEALRIRHCALSLVGEPIFYPHINKFLALLHAERISSFLVCNAQHPDQLAALG
TVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRERRFEQRTVFRLTLVKGFNI
EDEVMGYADLVEKSLPCFVEVKGVTYCGTSASAGAALTMQNVPFYEEVCTFVKALDLELR
NRKLGYGIAAEHAHSCCILIASERFKVDGRWHTRIDYEKFFECLNRGQPFRPEDYMGPET
PEWATWGRGGFDPRDERVYRKGKNKGLRPEIQAAPMEN
>A0A1J4J6C6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tritrichomonas foetus|TrEMBL
MEVFENSPLFHPMPNGDIQCLCCQHTCVIPPGKLGRCRARGNVNGKPYSPIWGRYTTAVD
PVEKKPLYHFLPGSKVYSYGTVGCNFNCQFCQNSSLSMWKLDIEDVKCLKANDVGVLDLY
SPEQMVKEAIRTGCKSIASTYNEPTVSSEFSHEVFKLAKSKGLYTIYVTNGFESVETLNY
LGPYLDAVNIDLKAFSEDFYVRTLGGHLEGVCKTIKRCHAMGILTEVTTLVIPDANDSDK
ELTDIANFLASVSKDIVWHISAYHDDYHFQGRGRTPLATLKRAAAIGAKAGLKYVYMGNV
STDEGGLTKCPKCGNKLIQRGWFDATVSRDFVNGRCKCGETIPGVFVGGINLNPKINSVP
ANLLDEPTGMSIAQSSGDNSSFPKDFVVFASKGGTSKMLAEKIGERIGFNNIVDIATLSS
EQLHQASRVVFVVSTYGRGMPAPSANEFWTKLSSDSQKLDGLQFAVLGCGSSSFEGTFAA
FAKNLEQRLNEMGAKEVIPLCTRDEMEDDDDEKVDGWIGQIKFAVRYTKK
>A0A1L9TSR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus sydowii CBS 593.65|TrEMBL
MADSSAAEGLLTLWHSFRLPFLVAIASVLVILRFRRVLQARSKAATASSVPPSPRSLSPE
KSPKSDVLPEIVEKKEAGSLSSGRVSPKPTAGPKRVTGKKPTKTAGKRSGSAANEEPQPV
TFIQPIIFWASLTGSTERYAQTVLEDLRTAAQSQANLEDRERGLLPPQILDLAEVDYDDY
FTTAPKPPSTSPGTRYVYCFLIPSYNIDTILDTFLGHLDETHHDFRIDTGSLSNLAGYAV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTNKKRAYPLGFGDVKSDAETSLKEWTSGFQ
DILGDIVKNGGLGEGVPGSGDPLESDEEQSDDEESGSTKPKARGRKKAQAVVDLEDIKMS
TDGQVGSSPIPVDFTTAGAGSQAIQPTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSP
DLIFDGVKEGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLELLH
GEQISSFLVCNAQHPDQLEALHRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQKCLDI
LREKRFVQRTVFRLTLVKGFNIDDEVVGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLT
MQNVPFYEEIAAFVVSLNDELKRRGLDYGIAAEHAHSCCVLIASTRFKVNDKWHSRIDYP
RFFELLEKEKADGTTFRPEDYMKETEEWALWGNGGFDPNDERVYRKGKKKTIQEATEE
>A0A7Z7AXS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus vulcani|TrEMBL
MARRRKNKNKDSSDDESEITDFKSLLRKQGYSLAGRHSAVKTCMWLRRSIKDEGECYKSV
FYGITSHRCLQMTPTLMCNQKCLHCWRPTEVDVPMPVGWDSPVEIVGSSIESQRKLLSGF
GGSAPLERWKEGNDPKHVAISLSGEPTLFPHLDELIDEFKEQGFTTFVVSNGTVPEMMAK
INPAQLYMSLDAPDRETYEKVCQPKSPVLWDNILRSLEILKSKETRTVIRITLVKGVNMF
DPEGYAKLIKIAEPDYIEVKAYMHLGFSRKRLPREAMPSHDEVMQFSEELAQHLGYKVAG
DVEVSRVVLLSKDGSVAHLL
>A0A6A9QAE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus infernus|TrEMBL
MVVSTLRIDTLSRIMEEMEKEKYHIIGNHSAYKKCHWTHEALTEGRYCYKGKFYGIESHR
CVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDETKLPITDDPEYIAEKSIEEHKRAVSGYL
GRKGVDPNMAKEAMKPAHVAISLTGEPTLYDRLGELIHEYHKRGLTTFLVTSGVRPDVLA
SLEEEPTQLFVSIQAPNERKHKLINRPIVANSWNLFLKTLEILPSFSSPTVIRMTMIKGF
NMSEEDAKDFAKLIEIAMPTYIEVKAYMHVGPSTLRLSRDAMPRHSEVREFAKLMEKYTG
YKIISEHVPSRIVLLSKLDKPIQIGNAWSDKWNWATKDTEDDIHGEYAEAELGSGNNQC
>A0A7C3SUC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQLSCNQHLLITLFKKQKYQLINEHSAVKKCRWLHQSLTQNKYCYKQKFYGIQSHRCIQM
TPSLICNMQCKFCWRIHPNEDLKPPLNFLIQKWSDPEEIVEECVKAQRRILSGYKDQVKK
GKIDGKKYFEALNPKHAAISLDGEPTLYPKLSELIQEFHKKSFTTFLVTNGTKPEVLKNL
SEEPTQLYLSIYAPNKKVFMNLCKPVNVGFWDKINESLELLSSFKCPTVIRLTLVKGENM
DDLDGYAKLIGKASPTYIEPKAYMFVGYSRLRLKFENMPSYEEVKAFSRRLSEKTSYNII
DESKESRVILLSVLEKPIKFSS
>A0A832XDG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
METKIPQSLLQVLKKQKYHLIGNHSAVKRCKWLNESLTHGRSCYKAKFYGIKSHQCIQMT
PSIFYCTQQCLFCWRPQSGDLKVTWNENDPPVWDAPARILEGSLKAQERILSGYKGNTQV
DWRRLREALMPRHAAISLAGEPTLYEPLGELIQEFHKKNFTTFLVTNGTNPNRLAKLEQE
PTQLYVSVCAPNQEVFRKACRPQIEKAWAKLNDTLELLQCFRCPTVARMTLVKGMNMENA
GEYARLMEKANPTYIEAKAYMHVGFSNLRLGFEHMPSHREVCEFASRLSDETGYKVLDES
ADSRVVLLSRRAEAKRFDGK
>A0A7J3LYP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLKGIEEVYYRQGYRIVGLYKHSAVKICEWTKESLRSRGGRHCFKQRWYGVQSHRCLQCS
TAIYWCTNRCLYCWRSFKGMRGLPLSEARWDEPETLLDEMIKAQMSLLIGFKGNPKVDRS
MLEEAFNPTNVAISLIGESLLYPYLSDFIELTKRRGMTSFLVTKGTVPDGLRRLSSYPTN
LYISLCSPDEDVFKKLETPLIPDGWNRMLEGLEVFSTFVNSRRVIRITLVKGWNMERIDG
YAKLIDKANPDFVEPKAYMWVGESTRRLPRDAMPTLGEVVCFAEKLAKATGYRLVDIFEP
SRVALLAK
>A0A8B2HQC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp. K4|TrEMBL
MSCSGEIVGNDDQLIQIRPAISEQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEHVSEPEEILKKLMQERKKLIM
GYYGDSRNDKERLDESLLPSHYAISLSGEPTMYPKLPEMIKYLKSLKETKSIFLVTNGQE
PDMIERLKKEDALPTQLYLSTNASDYESFQRINKPKYDDSWQRWNKTLEMLKDLDTRTVL
RITLIRDYNDQKEMIPSFVSMFEKASPHFIEIKSYMHIGRSTNRLEYSNMLEMDEVREFA
RGITKNSNMFSIMDESFVSRIVVLQNKQRNIERFISAYADTN
>A0A8J5CKF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Yarrowia sp. B02|TrEMBL
MFDELLDLWHGSRLMLIPIIGLVIFIVLYDEKKPVVSVESETKQVEKPTTTVKSSTRALD
EKPPMPVDFTTAAKPKRVPKTFGKGPKKLSVSLSSQVYVFYSTLTGSTERYARQLFEYLS
TKLKKEPILLNVDYIDDLDEYFVNSKAGSVYCFIVPSYETESPLDYFLDTIKETYNDFRI
DSRPLSKICFSVFGVGDKESWPEKFCYQAKEVDRGMAKLGARRLNPLGNGCVKTDFETNI
MEWREHFVDALEDGVVPEADDICSDDEDEEEDSKDGIVDVEDMGKIIGSSKPKRKSAKDI
MEADSCSAKEMVAKDSPTYKALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGI
KSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPKEIIDGALAGHYQKIKQLRG
VPGVSAERFAEAFRVKHCALSLVGEPIFYPHINEFVGMLHEKRISSFLVCNAQHPKELAA
MNQVTQLYVSIDAATKESLKAVDRPLNRDFWERLQECLAILREKRNQRTVFRLTLVKGFN
AEEVENYAKMVAKAMPCFIEVKGMTYCGTSKGNPLTMKNVPYYHEVLDFVEQLNEAVANE
GLEYGIAAEHAHSCCVLIAQKRFYIDGEWHTHINYDKFFDMLEAGVEFGPEDYTAATPSW
AQYGSEEAGFNPADVRHRRGKVVEV
>A0A0F2MI88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sporothrix schenckii 1099-18|TrEMBL
MASTSRASSPFIRDLLIVVVDAWHAYRIPILLATFAALVSLRIYLHVAGSGDDREGLLIF
PKIYDNTTVVDEKKKLQQQEQPPSVQEDVKIAVLQQTKTISYPGSTSDKKTITPTATKKS
STAKTANATTPSSTTTKAAAGPRRIKGELPKGNGAAAVARVPTRIQTIVFYSSITGATAK
IVRDYATELSTTLGELKPEGGSDSKGNVFAPVEVLDIAEVDLDEYFISPPKDASDAASGR
TTDYLYLFLLPSYNIDSINDTFLEHLKETHHDFRIDTAPLAPLLGYSVFGFGDREGWPTE
DEGFCFQAKEVDKWMAKLTGRKRAFPMGVGNTKTDAMLRLAEWSEGVVDVLGLVARTGSL
GTGVRGSGDAVETDDEDEDEASDDGSDAYDDGSNDDDGAADANGAAYDNDDVLFGGNAAR
NANVKRLKKAGVIDDVEDLGRLLRSSKEDDAVDDTAVDDVAEVPGTNVNKAPIAIDFTTY
GANDSSTTNGGPRRTGRKAAAPAPKEMVAKDTPTYKSLTKQGYAIVGSHSGVKICRWTKS
ALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIF
DGVKANHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHSENI
SSFLVCNAQHPDQLAALHHVTQLYVSIDASNRETLRKIDRPLHRDFWERFQRCLAILREV
RFRQRTVFRLTLVKGFNIDDEVQGYADLVEQALPCFVEVKGVTFCGTSTSAGVGLTMANV
PFYDEVCEFVTALEKELQSRGLAYGLAAEHAHSCCVLLASERFKRDGKWHTVIDYDKFFA
LLREKGPQGDFAPEDYMGPPTAEWATWGRGGFDPRDQRVDRKGRPIER
>A0A6S7M1Z8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lactuca saligna|TrEMBL
MSSTAATASISTTSLTTHLTILAFLSATTVYCFYKSSRLRHLKLSSPSTNPNLSSATRKG
KLFFISQTGTSRTLAQRLFNLLTSNNIPFELVDPNVYEPEDLHQENLVLIIASTWEDGNP
PSNGVFLSNWLSESAEDFRVGSLLLSKCKFAVFGVGSRAYGDNFNAVGRGLSTKMRSLGA
SEILPLCEGDVDEGELDKAFGIWSKEVIKVLKAGELKGNGNDLIEENGYEMIDGSEYEDD
DDDYEDEDEENGMESDIVDLEDIAGKAPSKKDMGAITSNGKKNGQKEMVTPVIRASLKKQ
GYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWQWKMDDPLMIVNSAIEEHKKMIKQMKGVPGVTAERLSEGLLPRHCALSLVGE
PIMYPEINSLVDELHKRRISTFLVTNAQFPEKIVSLKPITQLYVSVDAATKDSMKAIDRP
LFGDFWERFGDSLKALKDKQQRTVYRLTLVKGWNTEDVDAYSSLFGIGNPDFVEIKGVTY
CGTSATSKLTMENVPWHVDVKAFSEALAEKSNGDYEIACEHVHSCCVLLAKVDKFKINGQ
WHTWIDYDKFHDLVASGEPFGKREESQIHPLTFLSPGFHIVAEILLFEGGFV
>A0A534MY82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPAVD
ACNLACQFCWRTQEWGSNSLLAADDPAFIVDESIRGQRELLTGYKGNPNVSRERFLEAWH
PTNVAISLTGEPTLYKRLGEMIDEFKRRKMSTFLVTNGTTPAVLRRMHAEGRLPTQLYVT
VAAPNAEIYRKLVAAKSDHEWNKLRETLALLPTLPTRTVVRHTLVEGWNLGWEDEYAELD
RLGKPMFIECKGYSFVGESRLRLQAENVPSHASIRTFASRLADRVGYQIAAERDDSRVVL
LTPDGALHPIPQ
>A0A0G4FMM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vitrella brassicaformis (strain CCMP3155)|TrEMBL
MWSSLGRPDLRRGSSRGERVLVLFASLGGTAKAEARQLVSQLRLYLLSRAHVAVSSMSDY
NIDDLTSERCVIVVISTYTDGLPPPAGTSFFAMLEDWRNDFRVDKAALAQLRYAIVGLGS
HEYGEQFCRAAHTLDRLLHSLSAHRILPTCTLTDTADIPPQLTPWLTRLFPLVHAAMTGS
PDPPEIHAAAAAAAEADHESDVESDGSASDDGQEGGGEAEADDVEDIVGGKPSGEGSSAR
ETAREMVTSRQRAALTKEGYRIVGSHSAVKLCRWTKHQLRGRGGCYKHSFYGIESYACME
ATPSLACANKCVFCWRHHKNPVGKEWRWALDPPEMIVQQTIDNHRQLVKTLKGMPGVIPE
RLEAAMKIRHCALSLVGEPIMYPHINELIAMLHERHISTFLVTNAQFPEAIRNLKPVTQL
YVSVDAATPETLKAVDRPLFGDYWDRFVDSLTALRERRQRTVYRLTLVKQHNMQDACEYG
RLVSLGRPDFIEIKSVTYCGTSTASHLTIKHVPYHQEVLNFADAIISSSAELADEYELAC
EHEHSNCVVIAKKSFKIDGVWHTWIDYDRFHQLATSGELFGALDYCAPTPQWAVRGAQEK
GFDPIETRHYPKGKARRLRQTQDSQ
>A0A2E7S5Q4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPKIASRLSKQKYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDTLHKIDDDPYELYLESVRAHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEVFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKNESLGYHEDYARLDNLA
DPDFIEAKGFVYVGNSRNNLTIENMPSHDDVMEFSETLAPLVGREVLSEXRXSRVALIGR
EMIPVTLPEKVRDLPTDLGIAKPQKLVLPQA
>A0A2E2TSM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVASHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDAVCRPKWNTHAWEKFEETIDLLPSLDTRIVARHTMMKGINMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSIENMPSHDDIMDFSNKIAPLVNREVLSDSRPSRVALV
GREITPIPIPKATMFFPEDLGIAPSVKHLPMAG
>A0A2E5Y519|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLETLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQS
>A0A7L1PES2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oriolus oriolus|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVVQFTTTRSKRKGEKSHGTPASS
EGTADKLGNGCALPQAQEVRVAGVKIFYGSQTGTAKRFAKALAEAVTCLNLPVEVINMGD
YDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYA
VFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEE
EAGGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNGAAGTGRKEEAERREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALSLV
GEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRQRLEPVTQLYVSVDASTKESLRRI
DRPLFKDFWQRFLDSLKALAEKVPR
>A0A6A7A793|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiobolus disseminans|TrEMBL
MSLLDILTQLPAELLLIWHDHRVPILFSAIALAAFVRLTIYARTRRTKVSASPVPGSPIE
KKIEIRPEWLPENTTFNASALNIDNHAEDKTGAVAAIVKAKKGPKTVKGRKTPKKAPVAA
PSFDHKTDNIQPLVFFQSLSGTTERYATQFAKVLTEWKKGCNQSTSFLEPQLHDISYIEY
DDFFISPPKADANTKLFYIILLPTYNIDTVLDNFLENLQETHNDFRIDTAPLRSLLGYSV
FGFGDREGWPTEEEGFCSQAREVDRWMARLTGRKRAYPLGMADVKSETEDRLQEWRFGVQ
EALVELAEGRGLGDGVQGSGDPAESDEEEEEDIEEGNAQSTRVDEIEELGAMVNDSSASP
IPVDFTTYKSKSKPLIKSTAAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDG
ITAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLNIMHSNRIST
FLVCNAQHPAQLATLVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFTTCLDIIRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YDEVAEFVTELEKELSSRGLTYGIGAEHAHSCCVLLADETRFKRGGKWATRIDFERFFDL
YEGKVQGTRMEDGKVVGWRPEDYVGGETPEWALWGNGGFDPRDQRVYRKGKGPKPEEKSS
EGVEIELAKNAALEF
>A0A7K7P9V4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acrocephalus arundinaceus|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTSTRTKRKVTEPGTANKLG
NGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLDLPVEVINMGDYDPEDGLA
EETSSRSICVFLVATYTEGQPPEGAAWFCKWLEEAASDFRVGKNFLQGLRYAVFGLGNSA
YVDHYNSVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKAKFLTRLQML
CKGGKKPCSGKCKKGKCKSSGKQSKEGSDHEHGTSEHENTEAEELFETSSEEEAGGTGSV
IDVEDLGNIMGHMKKTKVLLLGGYGAKLNCLMICAFFSGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEA
IEKHQNMIKEFKGVSGVKPARLEEALAVKHCALSLVGEPIMYPYINRFVRLLHHHGISTF
LVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQQR
TVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVVS
FVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRTWIDYSRFQELVREYEQSGGSR
TFTAAEYMARTPPWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A7I8IIG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spirodela intermedia|TrEMBL
MASTPLSARFALLAFFSLSSLFFIYKSRRARHLRLASLAASLRGDEAARRGKVFFASQTG
TSEALARRLHGFLQSEGLAFDLVDARNYEPEDLQKESVVLLVTSTWEDGRPPPNAEFLAR
WLSESADDFRVGSMLLSRCEFAVFGVGSRSYGEGFNAAARSFARWMRSLGAFEVLPVCEG
DVDAGDVDEIFRAWSRNVVQLLQGEFLAGGPPFSKSEDGALEGSVEEYESEDEDEDEMVE
SEVVDLEDIAGKAPPVKLSVGSRNGGSNGVKKTAANGNMNGMKEMVSPVIRTNLEKQGYK
IIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGKSWQWKMDEPLEIVAAALDQHTKMIKQMKGVPGVKEEKLLEGLSPKHCALSLVGEPIM
YPEINSLVDELHRRQISTFLVTNAQFPEKIRTLRPITQLYVSVDAATRESLKAIDRPLFG
DFWERFIESLKALREKEQRTVYRLTLVKGWNVEDIDAYLNLLDIGEPDFIEIKGVTYCGS
TATSKLTMENVPWHSDVKAFSEALAQKSGVYEVACEHVHSCCVLLAKSDKFKVNEQWHTW
IDYEKFQDLVASGQSFRSTDYMAPTPSWAVYGAEEGGFDPHQRRFKKERRHGAAALSR
>A0A7S8HWI5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium culmorum|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEHVEIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPLVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKGHGDTDLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A7J6AUR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ameiurus melas|TrEMBL
MIMFVITLLTNAVSFVSAAEMPGYLDNAWLYAEAFLSAVWRNRLCVYTAAALLIGLWLTV
NMTRKKKKLANPVKAHKNSKSEKQKEQIPEKENVAGVRIFYGSQTGTAKGFARELAEDTQ
ALGFESDVIDLKDYDPEDKLSDECTSKRICVFLVATYTDGKPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAIFGLGNSVYVGHYNTVGKNVDKWLWMLSAARVMSRTEGDCDVVKSRN
GSIQADFQAWKEDFLRRLQALAKGEKKACSCECKKGSCKSKKKHHEEAEGEKHSSEELFE
SSSDPESGGEEEKAHGSVIDLEDLGNVMNHMKKAKKVEEDPSQLGRLSKLNGLKKAGSEE
ETREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQEALENHRNMIRQFRGVPGVRPER
FEEGLAVKHCALSLVGEPIMYPEINSFLRLLHQCHISSFLVTNAQFPEEIRSLVPVTQLY
VSVDASTKDSLKRIDRPLFKDFWQRFLDCLKALGEKQQRTVYRLTLVKAWNVDELKAYAE
LIALGQPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQQLASLLPDYDIACEHEHS
NCLLLAHHKFKVDGEWQTWIDYERFHELIQKYDESNGAKTFTALDYMAKTPSWAVFGARE
RGFDPSDTRFLRKNKTKDISGC
>A0A224YYN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhipicephalus zambeziensis|TrEMBL
MYPRRFVTFLLCALLMFHTVHAKGNVNEKSRSDWYPSSYTTTLCGGVLAVLFFVIAREKL
NLSKIKTQDPFKQRKRKRNGKSVKVLYGTQTGNAKILAEKLTAELDALDYDVEMVNLKHV
EPEECLLGQVKAKGLCIFIVSTYVDGSPPDEATWFYDWLKDTYADFRVHKYYLQGLNYAI
YGLGDSAYGDSYNKVGKDIDFWLSKLHATPVVPLCLNDESHDEGKYGTGKFPGWKDDVLA
YLEGRPSITTQPREAQIAPEDIAYESSSDEAEPELIDLEDLGNVRSTNKSKESKNVKNGE
ARPDMLTPLLRQSLGKQGYRLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEA
TPSLACANKCVFCWRHHTNPVGTEWKWNMDSPEMIVENALKNHYKMIKEFKGVPGVLRER
LEEGLQARHCALSLVGEPIMYPKIGRLVRLLHDQGISTFLVTNAQFPDALRELGPVTQLY
VSVDASSREALKRIDRPLFPDFWQRFQDSLSTLADKGQRTVYRLTLVKEWNMDEMQGYAN
LVALGKPDFIEVKGVTYCGDSKGARLTMSNVPWHEEVLSFVKQLVALLPDYSIASEHEHS
NCALIAHNKFRVNGQWNTWIDYERFHELVQRFYQTGESFTSLDYVAPLPHWAMFGAKERG
FDPSDTRMLRRSKKDISGC
>A0A8G0PA52|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma simmonsii|TrEMBL
MDAGSRPQLEAMVADLVEVWHIHRTTIILASLFLLAGLRIFLHTTEKREPLAALPKIYNQ
EQPKTSEKPIVKAQPVVETEKKSTGPRRIKGGLTRKSSQEGKTATNESTDRPAKVLVFFS
SVTTKTEKIARDYINALETFVDQKAKETDGKFLNPELLDLTEIDFEDYFVSPPKSAEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKGDHAERFAEWTSGVQDVIAQAAQTGFLGEG
VPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDVEDLGKMIRTKDGNEGT
RKAPLAVDFTTYTSANKKKAQAPIVKEMVAKDSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLAEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQKFF
ELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>M0L7B8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula japonica (strain ATCC 49778 / DSM 6131 / JCM 7785 / NBRC 101032 / NCIMB 13157 / TR-1)|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMENDAWDSLIDTLDVLAEKHDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTQEMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>I6U9T9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus furiosus COM1|TrEMBL
MDIKPGKITVQANPNMPEEIANLFRKQHYELVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTEVPEPWDDPAFIVEESIKAQRKLLVG
YKGNPKVDKKKFEEAWEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPES
LREMIKDDKLPTQLYVSLTAPDIETYNKVNIPMIPDGWEKILEFLELMRDIPTRTVVRLT
LVKGENMHNPEGYARLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIREFAEALVK
YLPGYHIEDEYEPSRVVLIMRDDVDPSGTGLEGRFIKH
>A0A832TVN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocalculus sp|TrEMBL
MRSKACDALRKQGYLFFSPESSAAVKPCMWSKRALRGGDMCYKHQFYGIESHRCIQMTPT
LRCNQRCLFCWRSLEHEVEEEIELAPEVILSGAQKLHKKGLAGYKPHPDVTPERWQAASE
TPNQVAISLSGEPTCYSQLPALVDLFRENGYTVFVVSNGTHPDVVEQLYPTQLYISLDAP
DEDTYTMLCRPKGDYWEQVLQSLSLLSSRRSAVRVTLVKGLNDHSPEAYGRIIADSAPTF
VEVKGYMYLGYSRSRLSMDQMPDHAYVRSFAEKIAESAGYRIRDESPVSRVVCLEEDL
>A0A6A7BVM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Piedraia hortae CBS 480.64|TrEMBL
MGSVLIALFWSNPTKENPPSVVSSSSPRKPARAQPRTIRGVKRPKRVTATAVTVKPVVFY
FSLGGATRTYAQRAFPDAELHDLAEIELDEFFLKIPSVDEGTSFFYLILVPSYDIDTELG
RFLTHLEETHHDFRVDSAPLTGLAGYSVFGFGERQGWSKMFCGQAAEVDRWMAKLTGRKR
GFPLGMGDVKVDGQVRLDEWVEGVTAVMRDITQGKGLGEGVIGSGDAVESGDEEQDVKTK
TGDLEDFKPMDFTTSSQPKPMVPETSPTYAALTKQGYTIVGSHSGVKVCRWTKSALRGRG
SCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPGLVFAGMKEG
HYKKIKMMKGVPGVRAERLTEAMRIRHCALSLVGEPIFYPHINELLAMLHKEHISSFLVC
NAQHPDQLAALGPVTQLYVSIDASNKRSLRRIDRPLHRDYWERFLRCMDILREKRPTHRT
VFRLTLVKGFNVEEEAEGYADLVLRALPAFVEVKGVTYCGTSTAAGAGLTMANVPFYEEV
CAFVLALEAALKKRGLDYGIGAEHAHSCCILLADKTRFFRKNKWHTLIDYQAFFKCLESG
KPFGPEDYIGDTTPEWALWGNGGFDPRDERVDRKGRRIAAVK
>A0A7N9IAM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca fascicularis|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKV
QWLTPIIPALWEAKQVNHLRSGVQDHPGQCGETPSPLKIQKISQAWWHMPVVSATLEAEA
GESLVPGIQRLQ
>A0A1D3KZV4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium congolense|TrEMBL
MITMLLKDEDKRDLEKKGYRFAGKHRHAAAKVCHWTRKSLVDEGVCYKERFYGIESHRCL
QMSPSIPFCHHKCMFCWRDVSITKTEWVEEYDEPKEIIEDCIENQRNLLCGFFGNPNVNM
KKIKEAQDPRNAAISLAGEPMLYPEIGGLLEEFKRRDFTTFLVTNGMTPSKLEALETEPT
QLYVSLDAPNENYYKDLCKPQIDNGWKLLNQSLDLLSSFNCRTVLRTTCVKGYNMIKPEG
YAELIKRSDPDFVEIKAYMYVGNSRKRLELDNMPPFSEVKEFAESVAKLCGREVVDEAYE
SRVVLLS
>A0A0C9S1C5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Wollemia nobilis|TrEMBL
MEATQSMCTAAGGSSLAARVALAALVSASFYCLWKSTRLKTTKSLTHHQKQEEKLQKPNP
QPCCRSKVRNPATQPNGCCKSSSTQKQENLNSGCCGGGESPGKIFFASQTGTSKTLAHRL
SKLLEENSIKVEVIDPRSYEPEDLAKESLVIIIASTWQDGRSPDNAAFLAQWLDESSKDF
RVGSGLLSKCKFAVFGVGSRSYGATYNLAARAFFSQLTGLGGLALLPAGEGDQDDGNIDG
DFNAWCRRLVESLLLEKPVAGENNLAEDGFSDYFSGEDSEEDKEEDASGDAIVDLEDIAG
KASFTAAKNGVSRKQFGKVNKVSKDFSGEKPLSLEENGPRAMVTPVIRASLEKQGYKIIG
SHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGK
SWRWKLDDPLQIVEGAIDQHTKMIKQMKGVPGVTQERLTEGLTPRHCALSLVGEPIMYPE
INTLIGELHRRQISTFLVTNAQFPEAIKNLTPVTQLYVSVDAATKERLKAIDRPLFGDFW
ERFIGSLKALRDKQQRTVYRLTLVKGWNTEELDAYKELFELGKPDFVEIKGVTYCGSSAT
STLTMENVPWHADVKAFSEALVARSNGEYELACEHAHSCCVLLANASKFKVQGQWFTWID
YDMFHQLAASGEAFSSKDYAAPTPSWAVYGAREGGFDPEQARFKKERRHGAPPTNS
>A0A1B1TAK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured Candidatus Thalassoarchaea euryarchaeote|TrEMBL
MSELMPMQNPVTKIEPKIAARLAKQSYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGI
ESHGCMQMAPNVDTCNLACTYCWREPHSDALTKIDDDPYELFLQSVKAHRRLLTGFGGHP
SVPREKWLDAQDPKHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLD
TLPTQLYVSVDAPNKEIFDRICKPKFDQAAFEKLEQTLELLPSLDTRTVCRHTLIKGESL
GHWKDYARLDNIADPDFIEAKGYIYVGNSQSNHTIENMPSHDEVMDFSRNLAPLVGREVL
SDRRESRVALIGKEMIPVTLPTKIRDLPKDLGIAKPQKFTLPQL
>A0A2R6EP69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QH_7_66_36|TrEMBL
MPKQVDDPDYHHVNHTAAQTCGWTANALRSEGRCYKNQFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELDDVEWDDPEAVVDASIELQRKLLSGFGGNDEVPREAFEEAMEPRHV
AISLDGEPTLYPYLPELIDAFHDRGITTFLVSNGTRPAVLRACDPTQLYVSVDAADRHTF
DETVGAVEDDAWPNLLDTLDVLADKEATRTVIRTTLVDGVNMHPPEWYAAMCRRADADFV
ELKAYMYVGHSRGRLDDANMPDHDAVRAFAEEMCEFLPDHDTLREVPQSRVVLLARDEDT
WVPKLKGGSDFWARD
>A0A0E3NN18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. WWM596|TrEMBL
MSLEERKEEKEGSGESFPEIQEENRDEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMFAKVSPSQLYMSLDAPDLETYLRVCQPKSPSLWDRINESLDIMK
DKCSRTVIRITLVKGKNMFNPEGYAELIKRASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELVKHLGYEIVDESEISRVVLLSKDGKKSPVKKVSCLD
>A0A663MN10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Athene cunicularia|TrEMBL
MGDCDPDDCLSEETSSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGNMYLRGL
RYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEADFEAW
KAKFLSRLQMLCRGEKKPCSGKCKKGKCKSLGKQSKESSEREQSASGYENTEADELFETS
SEEEADAEEAGGTNSVVDVEDLGNIMSQMKKAKRERELEEGDVGMSLTQENAGRKEEGER
EMVTPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPS
LACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIANHQNMIKQFKGVSGVKAARFEE
AMTAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSV
DASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDDLKAYADLIS
LGKPDFIEVKGMTYCGESSASSLTMANIPWHEEVVLFVQELADLIPDYEIACEHEHSNCL
LIAHKKFKINGEWCTWINYERFQELVQEHERSGGSKTFTAADYTARTPRWALFGSRERGF
DPLDVRYQRKNKARDVSGC
>A0A498KYZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorientalis pallida|TrEMBL
MSDSESGDGGPKQVSNPDYHSENHTAAQTCGWTKNALRGEGKCYKKIFYGIESHRCIQMT
PVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDASIELQTKLLSGFGGNDEVPREVF
EEAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLAECDPTQLYVS
VDAADRATFDDTVKAVEDDAWERLIDTLDVLAGKSETRTVLRTTCIQGLNMHHPEWYASM
FQRADPDFVELKAYMHVGHSRGRLDRDSMPDHERVVEFAEDVMEHMPHDVLKQVPASRVA
LLAKERNTLVPKLQKDSDFWKRDPVSGD
>A0A091H7M0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Buceros rhinoceros silvestris|TrEMBL
LDVSMDTWNFISACLVPLWLHRFYVYSAVAFGISVWMVIQFTTSRTKRKISEQGEKSTGN
PTAAAGIGNKLVNGYATLQAKEVSVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
SMGDYDPDDRLLEETTSKNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKSFLKG
LRYAVFGLGNSVYVDHYNTVGRNTDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEA
WKAKFLNRLQGLCRGEKQPCSGKCRKGKCKSSGKQNKESSDHEHGTSEYENTEAEELFET
SSEEEAAAEEAGGTNSVVDVEDLGNIMSHMKKGKREHELKDGDFGTSLTQENSGKESEKR
EMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPS
LACANKCVFCWRHHTNPVGTEWRWKMDQPERILQEALENHQSMIKQFKGVSGVKADRFEE
AMAAKHCALSLVGEPIMYPEINCFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSV
DASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIA
LGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRELTNLIPDYEIACEHEHSNCI
LIAHKKV
>A0A1D9QDG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)|TrEMBL
MAYDTWISRPIWSYEIDEIVALWHLHRIPIILTTATILILVRITLRPRASREKLSASPLP
ASPILPAVKEKISPPVIEEKKTNGVKAPRRIVGGVKKRKPSEENLQTSPEKIQILVFFSS
LTGTTERTASSFVEQITGDIRESGFGGEAPIKYLDPELLDLSYIDYDDYFINPPKGEPRT
SYFYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEE
GFCSQAKDVDKWLAKLTGKKRAFPLGMGDAKKDARERLTEWREGLVDVLEHIAKTGSLGE
GVVGSGDAVESDVEDIEDDDGEVLFDEQNVASRKVKTQKKEDSLNDLEDIGGVLINTETI
DNTVGEGSEELESDFTTVRLKKGKVKTAPVVAKEMVPKTSPTYAALTKQGYSIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWK
VDPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFT
SMLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQR
CLDILRERRFEQRTVFRLTLVKGFNIDDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAG
AGLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTR
IDYKKFFECLESGEKFGPEDYVGDETPEWATWGKGGFDPRDERVYRKGKNKVPLPESQGM
VMGEVQDGNEDTVAGDTLAF
>A0A0L0GAT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeroforma arctica JP610|TrEMBL
MKTVTLIWIAVLILALARNAYAPWTLVTTLTFSAIAVVLLVLHLTDDDGLDASRENHKAT
SLADKRKAIYTADQRTSAEAEASAKDAPSGCCKDASVASGTSAGEGYCKSAAVETSEQAR
ESGCCKSVSSDAQVSSGGCCQSEETASESGCCKTQAEEKPTYDEGRVYCKILFSSVKGTC
KGMAAELNALMLSELADGGLKKENVQVIDLADYNPLDLEEEDLQCLMVFIVPTYSGGLPP
ESSAGLCLYLEDCHLDQRVSKKHLQDIRYAVFGCGHSSYISAHYNTVGKNVDRWLQALGG
RRRFGLGLGNQDVTESKNGSIEADFTEWAQRLVRTYQNKPLGGPAAGDNVVEQNVVTEEA
YESDSSSYSDEEDGNQDDGMQDLEDMGPLMAKMKAQKKKESSGGPREMITPALRKSLTKQ
GYKLIGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIDSHRCMEATPNLACANKCIFCWRQH
TNPVGTEWKWKVDEADMIVNEAIKNHRALIKTAKGIAGLIPERYEEGLNVKHCALSLVGE
PIMYPQINRFIGLLHERRISSFMVTNAQFPEAITRLSPVTQLYVSVDAATPESLKRIDRP
LFSDFWERLMSSLDELGRKQQRTVYRLTLVAGFNIEEIVQYAKLIQRAKPQFIEIKGVTY
CGTSDASVMTMQNVPWHEEVVGFVQQLCDLTPGYSIASEHEHSNCVLVARDEFKIDGQWH
TWIDYDKFHDLNDRFNKTGEKFTSLDFAVKTPSWAVFGCDEQGFDPEETRHYRRRQNKAG
GL
>A0A832WEL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum aerophilum|TrEMBL
MSCEYEALGRYHVLEGPRIKIRASAARALIERHYGVAGHAAVELCKWTKDAIEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLICSNRCVYCWRPTEEFDVISLNERFYMEPEEIVRGVLE
ERRRLLSGYWGHPQGRKRVKEALEPTHWAISLSGEPAMYPKLPELIKLIKSLPSTKSVFL
VTNGQHPEMLRRLIEEDALPTQLYLSTNAPNKELYYRINVPVYNREDAWEKWLESLDIIA
KAPTRTVLRITLIRSLNFDDKYIPEFAQIVKRGNPHFVEVKSYMHLGHSTFRLKREDMLS
HEEVKEWSFKLLKELEKIGARFAYMDDDEPSRIVVLQNLDRYVDRWIVPPGAPI
>A0A7K4ZXD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Centropus unirufus|TrEMBL
LDVSMDLWDFSYTCLVSAWLHRFYIYFAVAFGVTIWMVIQFLTTRKKGEKSHSHLASSEG
IESKVANGYATLQAEVHVARVKIFYGSQTGTSKRFATGLAEAIVSLALPVEVISMGDYDP
DDCLAEETTSRTICVFLVATYTDGQPPESAAWFCKWLEEAASDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWLLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLN
RLQALCRGEKSCSGKCKKGKCKSLGKESKESSDHEHEASEHENLEAEELFETSSEEEADV
EEAGGANSVIDVEDLGNIMSHAKRAKVLHFVCQSLCFVHQLLQGKTDGLIYSLFPGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPELILQEAIENHQNMIKQFKGVPGVKADRFEEAMTAKHCALSLVGEPIMYP
EINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDF
WQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESS
ASSLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKINGEWCTWINY
DRFQELVREHERSGGSKTFTAADYTARTPHWALFGSRERGFDPLDVRYQRKNKVRDISGC
>A0A7G9ZCC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-1 ERB7|TrEMBL
MEPKAISNYHEATLEKQGYHFVAPHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAHRCV
QMTPCIFCNQRCIHCWRPLEAFNMGEEAVAWDTPLEIVEGCIKEQRRLISGFKGSSKTSK
AAFAEAEEPKHAAISLIGEPTLYPYLQGLIQEFHSHGMTTFVVTNGTNPAVLREIHPSQL
YISLNAPDEAIYKRVAHADYWAQIQESLEVMKRMKERTVIRITAMAGTNMVDPGGYAKLL
ETANPDFVEVKAYMHIGYSRKRLTRDVMPSHTEVKEFAGDIAEHLTASGYDYKIVDESEI
SRVVLISNLSSEVKALPKL
>A0A1G8U267|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum texcoconense|TrEMBL
MSDSAETGVDAGTDADTDEGDDGGPMQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKN
IYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASLKLQKRLL
SGFGGNDEVPREVFEQSMEPRHVAISLDGEPSLYPYLPELIDAFHDRDITTFLVSNGTRP
EVLRECDPTQLYVSVDAPERHTFDNVVGAMEDDAWEKLLETMDVLAEKDETRTVLRTTLV
KGENMHHPDWYAGFYQQADPDFIEMKAYMHVGHSRGRLDRSAMPDHEEVVEFTERIGEYM
PEFTEVKEVPASRVALLSKTRDTWVPKLKKDSEFWERDPVTGD
>A0A8H7IZF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ascochyta lentis|TrEMBL
MAIPTSLEQLFTELLSIWHTHRVSVLVVAVVLALIVRLTTQLRSGREKVSVSPAPTSPVE
EKKTIELRPEWLPENTTIVTSSLNVDNHAEDDTNVVTAAAKVKKGPKTVKGQKRPKKVAK
PVIDYNHTTDKIQPLIFFQSVTGTTERRATQVAELLTSWTTGCDQSASFLQPQLLDLSDI
DYDDYFISAPKAEANTKFFYLILAPTYNIDTLLDAFIENLSETHNDFRIDTASLGGLLGF
SVFGFGDKEGWPSEEEGFCTQAKEVDKWMARLTGRKRAYPLGMGDVKSDAEDRLTEWRLG
VQEALVEIAEGRGLGEGVLGSGDAVESDEEEAEDEDSGEETPRVDDVEDLGGMASNTAAP
IPVDFTNYKSKPKVNAASAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDVIFDGIT
AAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLRLMHKNRISTFM
VCNAQHPAQLASLIPVTQLYVSIDASNKESLRKVDRPLHRDFWERFCACLDILRSRRFEQ
RTVFRLTLVKGFNMEEEVKGYADLVERALPCFVEVKGVTYCGTSAAGSAGLTMQNVPFYE
EVAEFVTLLEKELNSRGLFYGIGAEHAHSCCILLADSNRFKRNGRWATRIDFERFFDLYE
GRVQGTRMEDGKVVGWRPEDYIGPDTPEWALWGNKGFDPRDQRVYRKGKGPKSEQEAQAS
PMEVVSREVSLREVSRKAALEF
>A0A849R8M3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MISQNQKKLLEKQHYGLVGKHSSVKICEWTKKSLRNQGVCYKEKFYGKIHGIKSHGCLQM
TPATYFCPNRCLYCWRATDKTEANDMNGVKEDEPRTIVDGAILAQRKQLTGFKGFSGTNM
VKWKEAQDPTNVAISLTGEPTAYSKISDLITEYKRRKMAVFLVTNGLFPKHVFGMDEPSQ
FYLSMDAPTKEIYKKIDVPQFSDFWERFNQTIDLMPSMSCKTAVRLTMVKGWNDKNIDDY
VRLIKKTDTDFVEVKAYMHIGFSQYRLPMDAMPTHSEVIDFSKRLNDKLGYVSKDDDARS
RVVLLAKK
>A0A815P501|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFTFAQST
YDKLSKDLNRQVIIQDFNDVTDPEEFLQTQAKNQRTLLVFIPTYEDATPPPSAKWFLLHL
QEAATDFRVSKGELEKLTYAIFGCGNSLYFENFNKVAKEVDRCLSELGAKRLLPTELADE
NTAKSIYGGQEGHYSKWSSKLKSALETPKTEKCDCSNDTSTTTCCKTVTNGDHSIKNDDN
NNDEDEEEEPRIESDDDDEAGGCKDGNDDIIDLEDMGEYMENSSPTKTPKGPPKEMVTPL
IRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHSNPVGTSWQWKTDDAKTVTQGAIDNHYKMINTFKGVPGVLPARLAEGMKIRH
CALSLVGEPIMYPHINELIEILHSKQISSFLVTNAQFPDEIRTLQPVTQLYVSVDAATKE
SLKKIDRPLFRDFWERFLACLRALKDKGQRTVYRLTLVKGFNTEEIEQYAKLVELGDPDF
IEVKGVTYCGDSGASSLTMANVPWHEEVVTFVQALCERLPQYEVACEHEHSNCLLLANTK
FRVDGKWHTWIDYDRFQELVARHKATSGAETFTSLEYMAATPDWAVVGANERGFDPSDTR
WHRKSTAKKDLSGC
>A0A2D6WVM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MNKSQNKELMEKQGYRFIGKNKHSAVKICEWCRESLRGKRFCYKEQFYGKEDDIASHQCI
QFTPVAFHCTHNCEFCWRIGEFEQVPKDFKWDKPKELVDEAIEAHKLLLQGFKGAENQDI
EKFQQAMKPKQFAISLTGEPTLYPYLPELINEITSRGISAYIVSNGTNPEMIKQLAEKGQ
PTKMYITLPAPDEETYTKICHPAMKDSWKKILESLSLLEKFKSSVIRLTLVKDMNITNPK
AYADLIKQANPDYVELKAFMSIGGARERLSIDSMPSHEQVKEFAQEIVQYLDNPVKQSTF
KIVGENLPSRVVVLSGN
>A0A4U6XIS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum tanaceti|TrEMBL
MASSLQSAGFKDLLNNAHDVWQQVRIPVILFAAFGLLVLRFYLHTTEKKGELKALPKVYN
TEKPESRPIDEKKDEKKDIKQLSPEPPAESKAPKSNGPRRIKGGLVKRVSSDSANAETLV
RKIRPLIFFSSITANTPKIAKEYAERLEKELQRSTTDTGCSFTTPEVLDLADVDFDDYFI
TPPKSGDDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFG
DREGWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVVDVLA
MLAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLIEDSEAKPEKLKNRKNIDDVEDLGRI
MKSSNPDTGTTSRTAAAPIAVDFTSYGKMTQKKAPMSAAKEMVPKNSPTYASLTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYC
GTSTASNAGLSMSNVPFYWEVAEFVKSLEKRLNEKGLKYGIAAEHAHSCCVLLASERFYV
DGKWHPRIDYQRFFELLEERGPDGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRK
IGS
>A0A497RDN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobales archaeon|TrEMBL
MDTTISKKLLKDLKGYQIVGSHSAVKTCLWLKKSLKDRGVCYKQKFYGIKSHRCLQMTPA
LMCNQSCIYCWRPLELLDKLEGWDKPEFIVEGSIKAQHRLLSGFHGTPNVNKKKLEEAYK
PNQVAISLIGEPTLYPMLDELIEEYKKRGFTTFVVSNGTNPEVIEKIEPYQLYLSLTAYS
EESHLMLNKPSKNYWEDINKSLKILSQKDGRTVLRLTLIKGYNMEPEKYVKLIEKASPTF
IEAKAYMYLGYSRLRLPRTAMPEHEEIRAFSEKLSKLTGYEVKDESPISRVVLLT
>A0A662JIS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MYLSPQVKSLLVKQRYHLVGRHEHAAVKKCHWLHKALTEDKLCYKSWYGIQSHRCVQFTP
MLSCPNSCLHCWRIERSDPGVSWDELRLPPIDKPETLIEGALKEQRRIVSGYKSNPKVDR
KRFEEALHPRHFAISLAGEPTLYPYIDDLLGLLRSKGFTSFLVTNGLYPEVLSSLSNEPS
QLYVSINAPNETLYRKVCRPSMSDAWQRLNETLSLLSTFKCPTALRLTLIKGVNDVDIEG
YASLIEKANSHYVEVKAYMYLGFSRYRLKLGNMPRHSEVVRFAHLLSQHIGYEVLEDSLH
SRVVLLSRLPKPIEVA
>A0A0J6FCB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides posadasii RMSCC 3488|TrEMBL
MPDETFASGAQRALSLWHSYRGYALVLLPAVFILSHLIAARDKTAEASPPSIPSPPQSSK
AKQSRPTSGTEPPTSSTTPEEGTPSPNGAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDA
TKEISIQPIIFFSSLTGSTERSAKRVLERLNTEPLKDSRHSSRLLAPQLYDLSYVDFDDY
FVSPPKAPESNPNVLYFYCIIIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAV
FGFGDKEGWPTEEEGFCSQAKEVDKWMAKLTGRKRAYPLGLGDVKADGDKALDEWCSGMQ
EVLCDMVTNNGALGEGVPGSGDPLESDEEDVEDDEGRERLGEPKLPTWRILNSGGDASAK
QGSDIPIDFTTYSKTSTSFATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGVKICRWTKS
ALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPELIF
QGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVSMLHSEHI
SSFLVCNAQHPDQLAALDRITQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDIIREK
THVQRTVYRLTLVKGFNIDDEVVGYADLVERGLPCFVEIKGVTYCGTSTSAGAGLTMQNV
PFYEEVAAFAVALNEELNRRGLGYGIGAEHSHSCCILLASRRFHVDGKWHTKINYERFFE
LLEREKAEGVSFTPEDYMSETDEWALWGNGGFDPNDQRVYRKGKNKGNMSDAGSVPKGGV
VEI
>S3CAR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiostoma piceae (strain UAMH 11346)|TrEMBL
MASTSWAFSPLLQQLIDSATDTWHAYRIPFLLATFATLVALRIYLQVTEKPDDKDGLLVF
PKIYDADDKAQPSTEKPVVASEKVSLPVEVTPKKITTNGSAASTSKKNGATTSGPRRIKG
ELPKNSGSTAPAVIPERIQTIVFYSSVTGATAKIVRDYAEGLSKKLASIELPEDKAGKVF
ADAEVLDIADVDLDEYFITPPKKEGETEESAAATPTYFYLFLIPSYNIDCINDTFLEHLR
ETHHDFRIDTAPLAPLLGYSVFGFGDREGWPTEDEGFCFQAKELDKWMAKLTGRKRAYPM
GCGNTKTDAMLRLGEWSEGIVDVLGMLARTGGLGSGVAGSGDPVESDEEDVSADEEEGED
GGIEYEDEEVLFNTEATSAASRAVNVKRLKKAGVVDDVEDLGRLLQSGKDDAATEEVATD
SAANRAPIAIDFTSYGETAAPATKTVARRGPRKINGVVMPAPVVKEMVAKDSPTFKSLTK
QGYAVVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRH
GTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVG
EPIFYPHINEFLDMLHGENISSFLVCNAQHPDQLAALHHVTQLYVSIDASNRETLRKIDR
PLHRDFWERFQRCLEILREKRFKQRTVFRLTLVKGFNIDDEVRGYADLVEKALPCFIEVK
GVTFCGTSTSAGVGLTMANVPFYHEVCEFVTALDAELNKRGLGYGLAAEHAHSCCVLIAS
ERFRGKEDGKWHTVIDYDKFFELLRERGPDGDFTPEEYMGPATAEWATWGNGGFDPRDQR
VDRKGRPIER
>A0A5E4K0X3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MIPDKVKEVLKKQHYAIAGKHSAVQVCRWTKKSLLDEGVCYKEKFYGIKSHLCCQMSPAV
MWCPNRCLHCWRATELTIDSELKGNVDSPKEIIGKCIEAQRKLLIGFNVDEKSKKKQLSR
ANMKKYLEAQEPMQFAISLSGEPMVYEKVGELIAELRKRGKTSFLVTNGLYPEKLEEMKK
KKQLPTQLYISVNTPNKEMYNKFHRSSKKDAWERLNKSLEIMSKLVGKTRTVFRMNLVKN
LNMNPEMAKEYAEMIKKTNPMFVEIKGFMSVGFARQRLGYERMPYHKDIVDFAKLILKFL
PEYKFLDEKKESRVVLLGKDKKDMMIKKSEF
>A0A5E4IZX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MDSQDQARQTLTRQGYHLVGSGAVKPCLWLNRSLRGGDQCYKHHFYGISSHRCVQMTPTL
ECNHLCLHCWRPIDDPVPGNEPMEPAALLDGILQGQSKFLSGYGGAKTTSVNRLAEARKP
RHVAISLMGEPTLYPYLKEFIELIGKRGLTSFLVSNGTNPDVLDDLRPTQLYLSLNAPDE
DMYRRVCQPTTDLWPKILESLGLLSEHKCRSVVRMTVARGLNMERPEDFARIIRAAEPDF
VEVKAYMHLGRSRKRLERKAMPDHSEVLGYARALGKALGYELEAEVPLSRVALLSSGRIP
RSLGLQESQEL
>A0A452IT90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gopherus agassizii|TrEMBL
MDASVNTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWICFQFLATKAKKQDEKSTEKLTLS
KVTQDVLINGYTKPKMKEVYVTGVKVFYGSQTGTAKGFATILAEAILSLNLPAEIINMRD
YDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCKWLEEAVNDFRFGKTYLKGMRYA
VFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEGDCSVAKSKHGSIEADFDAWKAR
FLARLQALRKGKKKPCSGNCKKGKCKSKGRQSKEGSDREQRVSEQENTEKECELEEEAGK
TGPSQQSSGKNEDSERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHKSL
IKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTNAQF
PVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTL
VKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESAASNLTMANVPWHEEVVHFVRELAD
LIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWIDYDRFQELIQEYENSRGSKTFTAADY
VAKTPHWAVFGSRERGFDPLDTRFQRKNKTKDISGC
>A0A5E4IT43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MMIAADDATRLRKAGYVIVGSHSAAKVCLWTKRALLDRGFCYKQKFYGISSHRCLQMTPT
LPFCTQRCVFCWRSTKLFSTKWEGAVDEPDEIIDGCIDAQRLLLNGFKGHPDINIAKFRE
AQNPNQAAISLDGEPTLYPKIGEMITEFKRRGFTTFLVTNGTRPKTLASLPTLPTNLYVS
SCAPDEAAYKKTCAPTIKDGWKRLNETLELFPSLKTRKVMRLTLVKGLNLKDANGYAKLV
AKAEPDFVEAKAYMALGASRLRLGPDYMPTHEEIRAFAKELADASGYKYKDEQTESRVVL
LCK
>A0A2G3AX56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capsicum chinense|TrEMBL
MPLSLSSYPTRLTILTLLSATTLYFFYKSRRCLKSLNPNNPQTPKGKIFYISQTGTSKTL
AKNLHICLKLNGFEFDLVDPKEYEPEDLCKESFVLVVASTWDGGKSPENGGFFVDWLNES
VDDFRVGGLLLSECKFGVFGVGSGSYGDKFNVVARDFSRKLRKLGGVEVLELCEGDVDEG
NLDEVFGEWSKRVVGVLRGENGGGGYMGNDEVGDVRDEEEYNDDDDDELEENDEGSGIVD
LEDIAGKGPSRKKGVGDNKLVNGKLNGGVVNGEKAMVTPVIRASLEKQGYKIIGTHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWTWKM
DDPIEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMYPEINSLVD
ELHKRRISTFLVTNAQFPDKIRLLKPITQLYVSVDAGTKDSLKAVDRPLFGDFWERFLDS
LKALKEKEQRTVYRLTLVKGWNTEEVDAYSSLFSIGKPDFVEIKGVTYCGSSATSKLTME
NVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKMNGQWFTWIDYEKFHD
LVASGKPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRYKKERHHKSSRKENGSLKE
>A0A8C2PZ33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MLFLAVVSCLLYCTVGAEMSGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKKKMVDAVSPLLDKSVKNQKRSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVI
AQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNS
EEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKTKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRG
VPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYE
IACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPI
WAIFGARERGFDPSDTRFQRKNKTKNISGCLEGS
>A0A8C2JH13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKKKMVDAVSPLLDKSVKNQKRSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVI
AQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKAKFLNRLQALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNS
EEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKTKRMEGDEEDSQRVKLSKQNG
VRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRG
VPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNV
DELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYE
IACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPI
WAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A669PBL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phasianus colchicus|TrEMBL
MDTWNFFYTCLVSLWLHRIYIYSVMAFGISLWIAIQFFTTKAKRKDENSNGNLVSSEVVE
GKLVNGYATLQPKEVCVAGVKIFYGSQTGTAKRFAKDLAEAVTCLNLPVEVINMGDYDPD
DCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKMYLKGLRYAVFGL
GNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFEAWKSKFLSC
LQALCRGEKKPCSGKCKKGKCKSQGKQSKEGSNHERGAPEFENTEAEELFETTSEEEADA
EEIGGTDSVVDVEDLGKIMSHVKKAKRERELEDGNAGMSLLGETSGRKEAGERREMITAA
LRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANK
CVFCWRHHTNPVGTEWRWKMDQPEMILREALENHQNMIKEFKGVTGVRAERFEEAMSAKH
CALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKE
SLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKPDF
IEVKGVTYCGDSSASSLTMANVPWHEEVVHFVQELTQLLPDYGIACEHEHSNCLLIAHKK
FKINGDWCTWIDYERFQELVKAHVDSGGTQTFTATDYTARTPHWALFGSSQRGFDPLDVR
YQRRGKVRDVSGC
>A0A8C2JHQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FCEFFLYKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGN
SVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKAKFLNRLQ
ALAKGEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSDAESSAEEEK
SHGSVIDMEDLGNVMNRMKKTKVKTKPCRSTVVTYSLWYKLIGSHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAV
ENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFL
VTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRT
VYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYF
VQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKI
FSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A0E3SQ46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcoides methylutens MM1|TrEMBL
MSSKDKEELMTIPEIPDFEALLKKQGYSLAGTHSAVKTCLWLGRSIKDEGECYKSRFYGI
TSHCCLQMTPTLRCNQRCLFCWRPTEAEVSFPKNWDSPVEIVGSSIKAQRKLISGFGGSA
PRERWEEANEPKHVAISLSGEPTMYPYLPELVEEYEKQGFTTFIVSNGTVPEMMERIEPS
QLYMSLDAPDRETYEKVCNPKSPELWDNINRSLEILGKKDNRKAIRITLVKGVNMIDPAG
YARLIEIADPDYVEIKAYMHLGFSRARLPREAMPSHEEVLSFAKEVAGHLGYSIADEVEV
SRIALLSKDGKVTYID
>A0A024WU73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum MaliPS096_E11|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNKKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRDTNNTNIMNNTNNTNIMNNTNNTNIMNYTNN
IRTGENCVSESETSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSH
SAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKW
RWNMDKAEIIVEEIIKKHKAMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEIN
KLIDELHKRNISTFLVTNAQFPQELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDR
YIKCIKILKNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQG
YQLTMQNIPWHEEVYQFAWNLINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTW
IDYEKFHQLVKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A7L2DCW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Catharus fuscescens|TrEMBL
DVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGIILWIVIQLITTRTKRKVSKDLLQDCGAE
KLGNGCAPTQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPED
GLSEETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYAVFGLG
NSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTQL
QALCKGEKKPCSGKCKKGKCKSLGKQSTESSDHEHRTSEHENTEAEELFETSSEEEAGGT
DSVIDVEDLGDIMGHMKKAKREQELQEGAAGAGRKEEAVRREMITPALREALTKQGYKLI
GSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVG
TEWRWKMDQPEVILQEAIEKHQNMIREFKGVSGVKAARLEEALAVKHCALSLVGEPIMYP
HINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDF
WQRFLDSLKALAEKQQRTVYRLTLVKSWNVDELKAYADLISIGKPDFIEVKGVTYCGESS
ASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFRVDGEWRTWIDY
GRFQELVREHEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDVSGC
>A0A8B8RE84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Camelus ferus|TrEMBL
MMKFATILAEAVTSLELPVAITDLKEYDPDDHLVEEVTSKNVCAFLVATYTDGRPTESAE
WFCKWLEEASSDFRFGKTYLKGMKYAVFGLGNSAYVSHFNKVGKNVDKWLWMLGAHRVMT
RGEGDCDVVKSKHGSIEADFRAWKAKFISRLQALRKGEKKSCGGNCKKGKCESNQRGSEG
TEPGPHPPDRVHQRDAEEEEPVGSTSEEESGSEDHQSLNSVIDVEDLGKIMDHVKKEKRE
KEQQEGETSAFRSTAKSDASERRAMISPALREALTKQGYQLIGSHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAI
ENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHECRISSFL
VTNAQFPVEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRT
VYRLTLVKAWNVDELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVARF
VCELVELIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQELIQEYEDSGGSKT
FSAKDYVARTPHWALFGANERGFDPKDTRYQRKNKSKDVSGC
>A0A1V5A631|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon PtaU1.Bin066|TrEMBL
MHSGPCDALRRQGYQFFSPDSSAALKPCLWCKRALRGGDMCYKHQFYGIASHRCVQMTPT
LRCNQRCLFCWRSFEHEYPGERDLSPGEILSMVKPLQKKALSGYKPSPYVTPERFAEALD
PKHVAISLSGEPTLYPHLPELIDLLTREGFSTFLVTNGTRPDVVARCRPFQTYVSLTAPD
NETYRKVCRPMEDTWEAIQQSLSLLGSRRSAIRVTLVRGYNDFSPDAYARMIQDSGASFV
EVKGYMFLGYSRKRLERGNMPSFAHVKEFAEKIAAACDYEARDENPASRVVCLERIR
>A0A8H6FWM0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Letharia columbiana|TrEMBL
MEVFGRPASGSKDRGILIYGMWIALLADQIHLTSGIAFILDQWHEYRYFLLLAAVLLGLA
VFMHFDNRLRRERLTPSPAASTPEYGTVEKPGWLNEKSKSTILAEREDERSEKAEPYENV
AMQFPNVSVRPRPGPKRVTGSKVDRKPKSERSAHRRIQPLVFFSSLTGTTEIRALALLNE
LHTLLKDHSSTVLEPQIHDLSYIDYDDFYVTPPKSHQIDQHVQYFYLLMLPSYNIDTTLD
TFLAHLQETHNDFRIDTAPLSGLAGYSVFGFGDKEGWSTEKEGFCSQAIEVDKWMAKLTG
RKRAYPLGLGDVKSDSERRLGEWRDGVVKALLDIAANGGLGEGVAGSGDAVESEEEDADE
AAEPGTVLKVEARRPAKRKRQQKNSPVDDLEDLGGKSGDASEFRSPLPIDFTTSSLTSTT
PQAPKAMVPVSSPTHAALTKQGYTIIGTHSGVKICRWTKSALRGRGSCYKFSFYGIKSHL
CMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEMIFDGAKEGHYKKIKMMRGVPGV
RAERFQEAMKIRHCALSLVGEPIFYPHINEFVAMLHREHISSFLVCNAQHPDQLATLKSV
TQLYVSIDASNAESLRKIDRPLHRDYWQRLLRCLDILREKRFRMRTVFRLTLVKGFNIDD
EVEGYADLVALGLPCFVEIKGVTYCGNSSSAGAGLTMQNVPFYDEITTFVEVLNAALERR
GLEYGIAAEHAHSCCVLVASKRFYVEEKWHTIIDYEKFFECLESGKDFSPEDYMGPPTPE
WATWGNGGFDPADERVDRKGKPKVEKLR
>A0A384AH68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Balaenoptera acutorostrata scammoni|TrEMBL
MGPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKAPRDL
MTNGYISLQRKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGWPTESAEWFYRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKRCGGNCKKGKCESNQHGSEAVEPGPHAQEGSHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSAAKNEASERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYARLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIADYEIACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRK
NKSKDISGC
>F2QV97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Komagataella phaffii (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1)|TrEMBL
MDHGPWTIELGMKRQGSVWVSAELVPFSVFKDFSSQFLNANHNTPRIPYDATSSPSIIYK
TKFLGVHSTSASTVSILTYALAYLHPTFIGSHYYYIINYISFPAQIRVEKKINPIYTLMA
LINHLILVSALVCYLATGGRISIVCLAAVLYCLLQSSSTQPSTSRSTTSACGHTKSPERT
IPSPAKDEASYEILANGAVKLNRTFNKNKQSSTFKRKDDTKQRKKRVPKIFKANKPSSPK
FKEGLTATSHSLLDSNFIIFYSSLTGSSAKAATTLHGKLSEIATNKPQLLNMDEDVNDLE
DYFVNTPDLKNLVYILVLPSYDTDSPLDYFLESLEETSNDFRIDKFPLKKLAGFTVLGLG
DSESWAEKFCYQAKLVDKWLSKLGARRIFPLGTICIKTGGEPKINEWIDIFDETLKDDDP
MLTENEPEATIRDSNNDYDDDDADVSDDTLVDVEDMGRMIAKTKEENEIAQVTEKKEMVA
KDSPTFKSLTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKFAFYGIRSHLCMETTPSLS
CSNKCVFCWRHGSNPVGTTWRWQVDQPEDILNGALEGHYKKIKQMRGVPGIVSDRFNEAF
TVRHCALSLVGEPIFYPYINEFLQMLHAKHISSFFGVQCPAP
>A0A200Q967|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macleaya cordata|TrEMBL
MSDDIDDLLEKMTSLFAQPLPPKPIAVTTRESSDPNDWRLSLLVKPYSTRVFNPGGLCEI
LRRIWKPKGEIYVQDFYTGSYLVSFKDEKDHDRVLTHSPWSMGEDLIALERCVPNKQPST
YSFSQTELWIQLHDLPINFRSPSAVTWLASDLGIVRPIMEMECRKWSKYARIKVLVDIRK
ALRNFLDIKLDDGSICRIMVKYECLPRFCHSCGCLGHVMKRCPQLIEFSSKFSDSWPEDK
KRQFRELLKPRFDDSLKASDPFSKKDDDARLTNDPREGPDIEKQQENTLPEDVAIPTIRA
LDPKFSKLTESNDTDPDKQDNTISNNPVSTTSTGIILELDTPKHSTVILACLDTGKSTAK
MPLNTAIPMQTEDCPHLDNKTETASLPVVPPVKKPIACRKWKNKARGEYSNSSDSEIEFI
LSLKRPAPDLMNSQTPVKRLFLSSDEEFWVISGDHSSFASKCESLLTQLKNWSRATFGHI
DKELKKLMEELLQVQGLPPTDENLQRINELSDKLNEYTNHAATYWEQRAKSHWIRDHDRN
TKYFHTRATNRRRKNHISSIKRADGTWTTSFEEISSCLINHFQYLFTASPTAPIMPAFRI
CHHPLTTEQNLTISLISKIATRLTGWKRDSLSHAGRLQLIKSTLASITVYFMSAYLLPKG
VLEKILSIQRNFWWNNSEDHQSLMFTAWSNLCKPKMEGGLGIRIPERVNTSLIMNLTWRF
LTQPHSIWCQLLSAKYLKANSFWLEKKHWNPSPIWSSICAVKKHMQEATCWSVGDGHHIK
IWTDPWVPSIHGFRVMGLDHAKELVNRVADLIFHDSRCWNEALIFHCFPTHEAKAILSIR
LSAERDEDQLLWLKTPSGNFTAKSAYNLLSQREPSSSTNSTDGESFNWKGYWQLKGISPR
VHLFLWRILTKSLALKSSIARFNSSVDPSCPMCHLSLETYDHLFLKCDIARQIWFGSDIG
LVIDRNDPLTNLRRIFNQWISSPNTLEIAKRGCALLWTLWKSRNRVVFDNAQIDITQIIR
EAHRIYHEHQAPPIFHGLNNTLIEATVSISNQNLSWEKPPPGTIKINVDGATGNNSIAAG
IIARNEEGMVLACRTFFDGCWTGKDAPIEAEANAFLKGLELAAHYPNTPSIIEGDSKMIV
TYITDDRLLFPWRIRSIILDSRQLLRSNPLSSVRFVPRTKNKAAHCLARQAINFKGVKTN
YKMTLTSSSSSSSSSSLQARLALLALLSASTFYCIWKSRRLKQLKLSSQNPNPNPKTNCS
SSRGKLFFVSQTGTSKTLAKRLLDILNSNNIVFDLINPKDYEPEDLSKETLVLIIASTWE
DGKPPPDAGFFANWLAESVEDFRVGSILLSGCRFAVFGVGSGSYGESFNAVGRDFSKMFR
ALGALEILPLCEGDVDGGDLDGVFDVWNKKLIGVLKGENLKENGEVSGTGLVSDSENESN
YESDDEEEEEGSESVIVDLEDIAGKAPSKKSSTSSTVKAEANGEREMVTPVIRASLQKQG
YKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWRWKMDDPLEIVNGAIEQHTKMIKQMKGVPGVKPECLSEGLLPRHCALSLVGEP
IMYPEINTLVDELHRRRISTFLVTNAQFPERIRMLKPITQLYVSVDAATKESLKAIDRPL
FGDFWERFVDSLKALREKEQRTVYRLTLVKGWNTEEVDAYFNLFSIGQPDFIEIKGVTYC
GSSATSKLTMENVPWHSDVKAFSEALALKSNGQYEVACEHVHSCCVLLARTEKFKINGQW
FTWIDYEKFHDLVAAGKPFSSNDYMAATPSWAVYGADEGGFDPDQSRYKKERHHKVKASE
N
>A0A4D6MDJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vigna unguiculata|TrEMBL
MSISNSLSSVPARLTLLALFSATTFYCLYKSRRLRYLKLSLNPNPKPKPKIIFLSETGTS
KTLALRLHRLLASSGVAFDVVDSRHYEPEDLPKETLLLLVASTWQDGAPPSASRFFATWL
AEAAADFRAGSLLLSNCRVAVFGVGSRAYGESFNAVAKGLATHLRELGAKEVVPLCEGDV
DGGDLDKVFDRWCEKVVAVLKGGGVAECDDDVGGGALEYGVYSSSEEESDVESEIVDLED
IAGKAPSRRKAVANGEESNGKLSGRKEMVTPVIRANLEKQGYKIIGSHSGVKICRWTKAQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPMEIVN
SAIDLHKNMVKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINALVDELHKRRIS
TFLVTNAQFPDKIKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALREKH
QRTVYRLTLVKGWNTEDVDAYSKLFSIGDPDFVEIKGVTYCGSSTTSKLTMENVPWHTDV
KAFSEALALKSQGDYEVACEHAHSCCVLLAKTNKFKIDGQWYTWIDYEKFHDLVASGKTF
DSRDYMTATPSWAVYGSEEGGFDPGQVRYRKERHHKSSRNQSG
>A0A0E3LTA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei SarPi|TrEMBL
MPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>A0A7K4C7Z3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MEKRKNIQIKDNQNKEKKDRKVKENNDRKKKELIPEKVKNILKKQHYSIVGRHSAVEICR
WTKKSLKNEGVCYKEQFYGIKSHLCCQMTPAVMWCPNRCIHCWRAIENTIDSRLGNDIDS
PKEIIDGCIEAQRKLLIGFKIDKNSKKKQMSKADIKKYQEAQEPMQFAISLSGEPLVYKN
IGGLVEELRKRGKTSFIVTNGLYPEKIEEMIEKNQLPTQLYISVNSPNKEMYQPFHRSSK
IDAWERLNKSLELMSKIKGKTRTVFRINLVLNLNMIHPEQYAELIKKANPMFVELKGFMS
VGYARDRLGYDRMPFHKDVVEFSKELLKFLPDYKFLDEKKDSRVVLLGKNKEDMKIKKNQ
I
>A0A2D5UZ93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MDPEYKKQLENQGYRFAGEHTSVKICGWTKKALTGCGTCYKQRFYGIKSHQCVQMTPATN
FCDHDCIFCWRSRNNSSFGVPDDPKAIVPESVGAQNVLLNGFPGNEKVDMALYKESKTPK
HVAISLNGEPLYYPKLSALIREYHKNGFSTFVVSNGQLPVVLRKLEAPTQFYLSLDAPNE
ELYKKIDQPMRKDGWSRLMESMDVLKDRKKEMRTAVRITLIKGLNDVEPERYAEILDRGD
PHFVEVKAYMFIGSSRQRLKMEMMPYHYEVKEFSERIAEVSGWKIVDEQEESRVVLLMKK
DFTMRKIDFSSLHLKGEGVQDSESEEVRDAVAFSEEHLDG
>A0A843D1W1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MDQAYKDLLIKQQYRLYKDHSAVKLCHWMKESMIHERHCYKQDFYGISSHRCLQMTPAIN
ECSHMCTFCWRIQEHDFEVKNWAEPKEMLDALIEHQRSLIWGFKGDPRCDPKMFEEARNP
NQVAISLAGEPITYPYMSEFLEECHRRHMSTFIVTNGTYPERLAALDVLPMQLYVTVAAP
NKEIYKSVCRPKISDGWEKLMQTLELLPSLDTRTVIRHTLVKGINMGWEEDYGRLDRIAD
PTLVEPKGYVFVGGSRNRLSMACMPSFDEIKEFSANLGQHIGMEIIKERADSRVVLLGHP
GMETDVRKIYHLDETSS
>A0A843G3K3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilaceae archaeon|TrEMBL
RNLLIKQQYRLYNDHAAVKLCHWMKESLTHGRVCYKQDFYGISSHRCLQMTPAINECSHR
CQFCWRVQDRDFEVKDWAEPKDMLDNLIELQRQLITGFKGDPRVSREMWEEANHPNQVAI
SLAGEPITYPYLSDFLKECHRRKMMTFLVTNGTYPEQLEALDELPRQLYVTVAAPNEEIY
KRTCVPKISDGWQRLMRTLELLPSLNTRKVIRHTLVKDMNLGWVDEYAKLDKIADTDMIE
PKGYVFVGSSRMRLHNANMPSFEEIMDFSTRLGDIVGMEVIKQKPDSRVVLLAKEGVETD
VRKYYHLDE
>A0A101DXQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon 55_53|TrEMBL
MSDEEYWRLLRKHGYQRVGAHSAVKSCLWLKKALRGEGMCYKGRFYGIFSHRCIQMTPTL
MCNQRCMFCWRPVEVEPPAYGWDSPSLIADGAIEAQMRLLTGYGGSSKTDGAALREAHTP
RHVAISLAGEPTLYPYLDELIREFSSRDMTTFVVSNGTCPEVIEKISPTMLYISLDAPDE
HTYRKVCRPIANTWNRVLESLELLPQKRCRTNVRITLVRGLNMHDEAGYATLLEKAQPDF
VEVKAYMHIGFSRNRLARDAMPAHEEVHAFASRIAHFTGYTLVDEVPISRVVLLARDDRT
PRWISGVGHE
>A0A024GUJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Albugo candida|TrEMBL
MQSSYSSAWVFAVPIAALLLTAVSLQLTDTWHPSIELLCSKFAQKSRQKPTKANKKKLKK
STISRKSPQKPHSDAPRAIPVRILFGTQTGTAKSMALDLEKRLFACNVSGFHFQPEVINM
NEYDQDHLEHESVVIFILSTWTGGIAPKDAETFCSWLKDMALDFRVSKTWLSHIFHAVFG
LGSAEYDEHYCTAAKELSKHLKLLGSSSLVEIGFGDDNIDQNQQFEQWSDQLIVKLCSQS
TMSPPATEVQTVNEEENDDETKGWLSQNQHRRQKRAEKQQDALRLDPKAMEWTEEDLMND
RLLTDDTLEINRDISTTKQSSEGESIVDVEDIGNTMRESQTANESQEMVTPMQRKALTKE
GYKIIGSHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHH
KNPVGRVWRWKIDEPEGLIVGSIERHQNMIKELRGLPGLNLERWKEAFTVRHCALSLVGE
PIMYPHINTFCRKLHQRRISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDALQAVDRP
LFKDFWERFLACLRELRRKGQRTVYRLTLVKSYNMQDIEKYAELIEIGQPDFIEVKAVTY
CGKSDGSDLTMKHVPWHEEVCDFCTALVEKTNGVYGLAAQHAHSNCVLLAKKTFCIDGQW
HTWIDYEKFHDLMDRYYTDGTMFSSSEYISPTPSWATFDAPEKGFDPCETRFYRTKNGKI
AETSYQSTESGCG
>H3BI07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Latimeria chalumnae|TrEMBL
MFPFLSAVLLGDVFPAQIAGTTEDASNYFYNHFVVLWQNRLYIYSFIFACISIWIGIQVI
LKRSKKQQGELNRNGILNTAKEMKENSPIFKEQEVQVAGVKIFYGSQTGTAKGFAKVLSN
EIQPLGLPSEVIDMKDYDPDDCLVDETTSKNICVFLVATYTDGQPTESAKWFCKWLEEAS
NDFRFGKTYLKGIRYAVFGLGNSVYTTHYNTVGKNIDKWLWMLSANRIMTRAEGDCNVVK
SKNGSIEADFSAWRAKFLSRLQTLCKGEKNSCDGSCKKGKCKSKKAHPKEAEGQNHEVQE
DVQHHSGEEEEEEMFETTSEEESGGEEEAKPGSVIDVEDLGRVMSSMKKAKKEKEIEEEF
AKTKLSKVSVGKTEKMERREMITPALRDALSKQGYRLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRYSTAEIGIKSSFSLKKPASKGKDILLNTK
DKGSLFVGRVPGVKADRFDEGMVVKHCALSLVGEPIMYPEINRLLKLLHHHNISSFLVTN
AQFPEEIRNLEPVTQLYVSVDASTKDSLKRIDRPLFKDFWQRFLGSLKALADKRQRTVYR
LTLVKAWNVEELRAYADLVALGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVIYFVQQ
LADFLPDYEIACEHEHSNCLLIAHKKFKVDGDWWTWIDYDRFQKLIKEYKESSGSKTFTS
SDYMAKTPPWALFGAKERGFDPIDTRFQRKNKTKDIAGC
>A0A2H5NSG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Citrus unshiu|TrEMBL
ISYCRLWGVREMAIARFARLGRHAKRPHGLCVKMTAVAILGLCFIFAWSTFSSSANSVTT
QRESFDDIAEPVSADTKVISSKPQYTERKRQWHEIGKEEDKKVKLESDLDKAKEKKINGS
ASVTVIKHESRKKNEKTVPNVKKQKHTVKSVNEETNEENEKSESDDSLKEDEEEQEQEVV
DGKEEESVSESEVNGETEGDVDLVQQENEQSVVTVEGESGRSRSTGKKRKVKGPVFDPKA
HYSWKLCSTRSKHNYIPCIDNESGFGKFQSYRHTERSCPRSPLMCLVPLPHAGYGSPVSW
PDSKLKILYKNVAHPKLAAYIKKHNWLVESGEYLTFPQNQSEFKGGVLHYLESIEEMVPD
IEWGKNIHVVLEIGSADSSFVASLLDKEVLTLTVGLKDDLVDLAQVALERGFPAVVSPLG
NRRLPFPSGVFDAIHCDGCSITWHAHGGKLLLEMNRILRPSGYFILSTKHDSIEEEEALT
TLTASICWNILAHKTDEISEMGVKIYQKPESNDIYELRRKKNPPLCKENENPDAAWYVPM
KTCLHTIPSSIEQHGTEWPEEWPKRLETYPDWLNDKEKLSSDTRHWKAIVDRSYLTGLGI
DWSKIRNVMDMKSIYGGFAAALAQQKIWVMNVVPVHAPDTLPVIYDRGLVGIYHDWCESF
GTYPRSYDLLHADHLFSRLKSRCRQPVSIVVEMDRILRPGGWAIVRDKVEILDPLEGILR
SLHWEIRMTYAQDKEAKRLHALLTSNDLLFDLVDPQTYEPEDLSKEALVLIVASSWEDGK
PPEAAKFFMNWIDESANDFRVGSLLLSNCKFAVFGVGSKSYEKTFNMVAKDLSKKMRELG
AGEVLPVVEGDVDGGELDVVFEDWSKRVVAILKSGGDRLENGIVNGEASIVGVESDPVYH
EYDDDEEEEDVVESEMVDLEDIAGKGPSRRSVNVAETNGKVKDGKRDMVTPVIRASLEKQ
GYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWQWKMDDPIEIVNTAIDLHTKMIKQMKGVPGVTLERLNEGLTPRHCALSLVGE
PIMYPEINTLVDELHRRRISTFLVTNAQFPDKIKLLKPVTQLYVSVDAATKDSLKAIDRP
LFGDFWERFLDSLKALRDKQQRTVYRLTLVKGWNTEDIEAYSKLFSIGNPDFVEIKGVTY
CGSSATSKLTMENVPWHADVKAFSEALALRSEGEYEVACEHVHSCCVLLAKTERFKVNGQ
WFTWIDYEKFHDLVASGRPFSSKDYMAASPHWAVYGAEEGGFDPDQSRYRKERHHKSISI
AHCNTIKQFSTHGSICVKLKIVLTGEQILRFFISILSMKDVCRVCSVRSDPYPKNDTGT
>F0QX82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulcanisaeta moutnovskia (strain 768-28)|TrEMBL
MERIDQVIKETLRYHVINEVNSRIRIRITDDTRAKLIKASYGIYNHSTVELCHWTKSALV
KGQSCYKFKFYGAPAGGSHRCAEFSPVGMICSNRCVYCWRPTESFDSFIPSEDLVDDPEE
IVQGILRERYRLLTGYFGNPKSKDRAKEALVPTHWSISLSGEPTLYPKLPQLVRYLKGLP
STKSVFIVTNGEHPEMLERMQREDALPTQLYLSCNAPNKELFYRINVPVMYREDAWERWL
RSLELLSRLNTRTVIRITLIRSLNYDFKYISEFAKLMLIGNPHFIEVKSYMHLGHSTFRL
KRSDMLRHEEVREWAMKLLDEINRLGGNFRHMDEDEASRIVVIQNMSRYIDRWIVRPEEQ
RKYSNYV
>A0A674JQF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Terrapene carolina triunguis|TrEMBL
MLNFWLVFQVLTILAACADTHAMDASVDTWGYFYTHLMSIWLNRFYIYSCAAFGIGIWIC
FQFIATKAKKQDEKSTEKLTPSKVTQDVLINGYTMPKTKEVYVAGVKVFYGSQTGTAKGF
ATILAEAILSLNLPAEIINMRDYDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCK
WLEEAVNDFRFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEG
DCNVAKSKHGSIEADFSAWKARFLARLQALCKGEKKPCSGKCKKGKCKSKGKKSKEGSDH
EQRVSEQENTEVEDLFETTSEEELGAEEDGSRNSVIDVEDLGKIMGHMKKAKKECELEEE
AGRTGPSQQSSGKNEESERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREAIENH
QSLIKQFKGVPGVRVDRFAEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTN
AQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKGVTYCGE
SSASNLTMANVPWHEEVVHFVRELADLIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWI
DYDRFQELVQEYENSRGSKTFTAADYVAKTPHWAVFGSRERGFDPLDTRFQRKNKTKDIS
GC
>A0A7C2BKB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermosphaera aggregans|TrEMBL
MTVNFHEVKRKREEFWNSSLAYKAIYDRLVKQGYHLIGTIGAVKRCHWTKEAVIRKRFCY
KCLWYGIESHRCIQMTPVAAWCWNRCLHCWRIQPEDIGMHWDDTRPPVIDDPEVLVEESI
RVHREIMAGYKGNPVADQSMVEEALRPKHAAISLTGEPLLYPRLSELIEEYHKRGLTTFL
VTHATRPDVLKSLSTEPSQLYISIESWDKASYEYFNRPLVPRAWELFQETLELIPSFKSP
TVFRFTIVKGYNDNEKALESFSKFVEKAQPTYIEVKAYMFLGGSRGRLEHSNMPSHDEIR
NVGRILSEKTGYKLLSESVPSRIVLLSRIDKPIRHGKGCPDGVEHPEKYAPAFSKEYEEL
TD
>A0A1Q6DV40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanohalarchaeum thermophilum|TrEMBL
MISQEQRKLLEKQKYKIVGTHSAVKLCHWLKEGMKGNKGCYKERFYGIDSHRCLQMTPSV
TSCTQQCLFCWRPLETWEGTEITEISEPEDILENSIEAQRELLTGFGGSLDIYDEDLWEE
AKKPKHVAISLAGEPTLYPKLSAYIKRCHERDLTTFLVTNGTNPQTIKDLNPLPTQLYIS
LDAPNKDIYQKLCRPEIEEGWKRINRSLKLLSELKTRTVIRITLVNGINDKNINGYAKLL
NKADPDFIEVKSFMHVGNSRDRLEREQMVENDGIKDFSKQISEKTIYEVEDNVEESRVSL
LKKPRANPKLRELG
>A0A8C9KJ41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panthera tigris altaica|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQDKNSKEKSVPKATRD
LMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQEYDPDD
HLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVFGLG
NSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTKFISRL
QALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLGKIMNC
VKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
MILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFLKLLHE
CKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNSLKAL
AAKQQRTVYRLTLVKAWNVDELQAYAELVTLGNPDFIEVKGVTYCGESSASSLTMANVPW
HEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQELVQEYE
DSGGLANFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A524E6W6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MLINKQWGIWAGGSLTQDMPPELREKLQSQGYHLLGERGAFKACQWQRKSLISGKTCYKQ
RFYGIESHRCLQMTPTVDKCTQQCEFCWRVTPDDLGVEWNQVDVDAEEVLSPEELLEETL
MANLRSLGGYNPEAGADVPEKRYLEARDPKHIAISLAGEPTLYPFLSDFVQAIRKRDMTS
FLVTNGTQPDTLRSLTLPTQLYITLAAPSERLYKKLCRPAIADGWSRIQESQKLLSTLSC
RTVNRLTMVEGYNMTDVHSYADMILTGEPDFVEVKGYMFIGSSRNRLRAANSPPHRSIRA
FSDKLEALTGYHLVDEQIESRVVLLSRNFDYDRINGV
>A0A7J4T143|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGKFYGIASHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLGEYIDLCHKHGMTTMLVTNGTFPKVLERLDPLPTQLYVSVDAP
NKKVFNEVCKPKWNKRSWEQFEKTIDLMPSLDTRIVSRHTLMKGINMSDQHIREFAALDN
RADPDFIENKGYVFVGNSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GQEITPIPIPEATMFFPENLGIAPSVKHLPIIQ
>F8MIH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neurospora tetrasperma (strain FGSC 2508 / ATCC MYA-4615 / P0657)|TrEMBL
MPFEIPGLNPAAVAEVARYAVELWHEHRIPILLSAVFLLGLLRTYLHLYSEPRQALLVLP
KIYEPNEKTKETTLVETEVEDKKTGAAITKKAKSANGGPKRIKGDKVRTKKGTNGNDTGS
ESEGPRKIQVLVFYSSLTGNTERYTKDFAKELGDLLVGQSDAESKAESNFLAPQVLDLAE
IDFDEYFLSPMKGPVDYFYCLIIPSYNIDSINDTFLAHLDETHNDFRIDTSPLAPLIGYS
VFGYGDRDGWPTEEEGYCVQAKQVDRWMAKLTGRKRAFPLGMGDYKRDGKERLSEWQNGI
VDVLKMIEQTGSLGEGVPGSGDPFESDEEDIAEDDGEVVYEESESKKTLEDVEDLGRIMK
QSQGDGPAAPIAIDFTDFGKTGKTVRARKSATVTVKEMVPKDSPTYTSLTKQGYSIVGSH
SGVKICRWTKSALRSRGSCYKYSFYGIASHRCAEATPSLSCSNKCVFCWRHGTNPVGTSW
RWVVDPPDLIFNGIKENHYKKIKMMRGVPGVSSSRFVEAMRIRHCALSLVGEPIFYPYIN
EFLGMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKNSLRRIDRPLHRDFWER
FQRCLDILRERRFRQRTVFRLTLVKDFNIEDEIEGYADLVERALPCFIELKGVTYCGTST
AGAAGLTMANVPFYQEVCDFVVKLNDALNKRGLGYGIAAEHAHSCCVLLASDRFKVDGKY
HTLIDYEKFFDLLEEKGPDGDFGPEDYMGAATPEWATWGNGGFDPRDQRVDRKGRPIERP
>A0A8B7IC56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apteryx mantelli mantelli|TrEMBL
MGSVQGSDQAYSGMFLLDVSMDPWNFFYTCLTSLWLHRLYIYSSVALGISIWICIQFFTS
KTRKKDEKFSGNPASAEVAEDKLVNGYATMKAKEVYVAGVKIFYGSQTGTAKRFARGLAE
VVTSLNLSAEVINMGDYDPDDSLTEETTSRNICVFLVATYTDGQPTENAAWFCKWLEETA
NDFRFGXAWFCKWLEEAANDFRFGKMYLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWM
LSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLGRLQALCKGEKKPCSGKCKKGKCK
SQGKQSKESSDHEHGASEYENAEAEEFFETTSEEESNAEEAGDTNSVIDVEDLGKIMSHM
KKAKKERELEEGGGRTSLSQESAGRKEEGERREMITAALREALTKQGYKLIGSHSGVKLC
RWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQ
PEMILREAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPEINRFLKLL
HQHNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLK
ALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVK
>A0A7J9G4J6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium harknessii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGDGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTRMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A0G2I8A9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diaporthe ampelina|TrEMBL
MEFNLPTSPWLAPPDSAIEFWHANRTAIILCTFFILVILRVYLHITQGNEPLHVFPKIYD
EKTNQNVAISSRLEDTLDEAKHIKPAGPRRIKGELNRRRDVQGSGSRQIKTLVFYSSVTG
NTDKIAKQFIQDFFAMLQTVASGPNCTFSVPEALDLAEVDLDEYFIAPPKLGVDGDVTTD
LFYLFLMPSYNIDTINDTFLEHVKETHHDFRIDTAPLSTLLGYSVFGFGDKENWPTEEEG
YCVQAKEVDKWMAKLTGRKRAYPLGMGDVKRDGTERMGEWTNGLTDIFGQLARDGTLGEG
VPGSGDPVESEDEADAAEDDGEVIFEEQEQAKPRKPKGSATLDDLEDLGRVLQNAKDEGN
AKSTAPLAVDFTTESKRKTPVQTVKEMVPKESPTFKSLTKQGYSIVGSHSGVKICRWTKS
ALRGRGSCYKFSFYGINSHQYLIFNGVKEGHYKKIKMMRGVPGVRAERFSEAMRIRHCAL
SLVGEPIFYPHINEFLEMLHGERISSFLVCNAQHPDQLAALKHVTQMYVSIDASNKESLR
KIDRPLHRDFWERFQRCLEILREKRFKQRTVFRLTLVKGFNIDDEVRGYADLVEKALPCF
VEVKGVTYCGTSISSSAGLTMANVPFYAEVCEFATALDRELNRRGLQVDGKWHTLIDYDR
YFELLEERGPDGEFRPEEYMGEETPKWATWGNGGFDPRDQRVDRKGRPIDT
>A0A7K3ZKK0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MDESYRELLTKQQYRLHNDHAAVKLCHWMKESMIRGRHCYKQEFYGIKSHRCLQMTPAIN
ECDHLCQFCWRVQGRDFEVAEWAEPKEMLDALIEHQRQLITGFKGDPRCPREKYEEARNP
DQVAISLAGEPIVYPYLSDFIGECHSRGMTTFLVTNGTYPERLEALDNLPRQIYVTVAAP
DEATYIRTCRPKITDGWQRLMRTLEMFPSLDTRTVVRHTLVKGLNFGHVDGYAALDRIAD
PDMIEPKGYVFVGDSRTRLTIDSMPSFDEILGFSEDLAERTGMAVIRQRPDSRVTLIGAP
GMRTELD
>A0A7J3TCS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MNNKYAEIYKKQHYGLVGKHSAVKVCHYTKSELTGHEGCYKGTFYGINSHQCIQMTPALN
SCTEGCSFCWRFQGFDSMHISDEDDPEFILEESIKAHKKLISGFKGNPNVTKERWEEAEN
PKHIAISLTGEPTIYSRLGEFIELCHRRGISTFVVTNGTLPMVLERLDPLPTQLYVTTAG
PTKEIFNDLLNPVIGNAWENFNRTLELLPSLDTRKVIRHTLVKDVNMPFVEEYTKMDRTA
DPDFIESKGYVHVGQSITRLSTDNMPSHDYIVEFSRELAKNLGYDFTSERRDSRVTLLSK
DPSKARIDFSTIRASILS
>A0A2Y9PKP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Delphinapterus leucas|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A075IBA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote SAT1000_44_H06|TrEMBL
MICNMSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVSDHSTVELCHWTKKSFRGEGTCYK
HKFYGISTHRCMEFSPAGMYCENRCVYCWRPMEFYETMEMKPENVAEPEEIMTNLMAERK
KLIMGHYGDPNQDKKKLDESLLPSHYAISLSGEPTMYPKLPKLIKHLKSLEATKSIFLVT
NGQEPDMIQKLGDENALPTQLYLSTNAADYESFLKINRPRYDDSWERWNKTLKMLSTLDT
RTVLRLTLIRGYNDNEKMIPSFASLLRQSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEV
RSFANKLVQENNAFTVMDESEISRIVILQNKKRFIDRFIPAYS
>A0A1W7RC76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Agkistrodon contortrix contortrix|TrEMBL
MDTPADTWDNFHAHLTFLWLNRFYLYSCAAFGISIWFCFQFLNKVKEQNKNRLAELNLPK
ITAAEKEQDPSLDKVHVAGVKVFYGSQTGTAKRFALVLTEAVATINLPAEIIDMQDYDPD
DSLIDEISSQNICVFLVATYTDGKPTENAVWFCKWLEEAANDFRVGKAYLKGLRYAVFGL
GNSVYADHFNTVSRNIDKWLWMLGAQRILSCARGDSNVVKSQHGSIEADFEAWKAKLLTR
VQALAKGDQKACSGTCKKGRCRSKPKVREEAKEQETSKHVEKEEEDLFETTSEEESDIEN
GRGADQVVDVEDLGKMMGHMKKSQKEHQTDGEVPIGVGTQHGKGEDGRREMITPALREAL
TKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNLIKQFKGVPGVRNDRFREGMEAKHCALSL
VGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKKI
DRPLFKDFWQRFLDSLQALAEKQQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIKG
VTYCGESSASSLTMANVPWHEEVKRFVQDLADLLPDYEIASEHEHSNCLLIAHKKFKIEG
KWHTWIDYDRFQELVHEYEQSGGIKRFTSADYVALTPPWAVFGAKERGFDPMDTRFQRKN
KIKDISGC
>A0A2A9PJL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps unilateralis|TrEMBL
MEALGWHPYLLTIDDVVDLWHAHRTSLILGTVAVLVAIRLFLRRHDDDVELVALPDVYRD
EAALSEKTNSGPRRIKGGAVKKAAVKREADVVTAMPPVKLIVFFSSVTDTTTKLALDYRA
DLAAATDQLARETGRPFLIPEVYDLAEIDLDDFFIAPPMSPAEAGLFYLFLIPSYNVDSI
NDTLLQHLRETHHDFRIDTAPLASLLGYSVFGYGDREGWPDEAQGFCFQAIELDKCMSKL
TGRKRAYPVGMGDVKRHHAQRFAEWAAGVRDVVVDVARTGHLGLGVRGSGNAVESDDDDG
GDDGQTLDQGVVLGDVEDLGNMVRAGGSTTKVKPPLAVDFTTYGQQMPVVKEMVPRGSPT
YAALTKQGYSIVGTHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKC
VFCWRHGTNPVGTTWRWVVDPPDLILRGVKEGHYSKIRMMRGVPGVRAERYAEALRIRHC
ALSLVGEPIFYPHIDEFLALLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRES
LRKIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVDEEVEGYARLVERGLP
CFVEVKGVTYCGTSTSANAGISMSNVPFYWEVCDFVRALNSRLADLGLGYGIAAEHAHSC
CVLLASERFRVGGVWHTHIDYDRFFDLLEERGPDGDWTPEDYMGAPTPEWALWGNGGFDP
RDQRVDRKGRSMEVTVVRERPPEPEPGEGERT
>A0A6I8QB24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xenopus tropicalis|TrEMBL
MTQTLILGILPQAAFVAAQQVDTDMSTNAWDFAYTHLMFLWLNRFYIYSCAAIGITVWFC
SHFITARKKQQNENVHNGSLPLKTKTLKSYNSPSIKEQDVYVAGVKIFYGSQTGTAKGFA
HMLDGEITLLGLPVEIINMKEYDPDDNLIEEATSKNVCVFLVATYTDGQPPESAEWFCKW
LEEASNDFRFGKTYLKGMRYAVFGLGNSVYSTHYNTVGKNIDKWLWMLSASRVMTRAEGD
CNVVKSKHGSIESDFEAWKAKFLSRLKALISGEKKPCSGKCKKGKCKSKMKSSTDAVEEE
AKHSEHEETEEETFETTSDSEPEEHGEPGSGLIDMEDLGKAMSIMKKAKREQDTNEEARN
RGKSLQSDEAKEKEEPREMITPALQEALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILEEAILNHQNM
IKQFKGLEMSEAAAVKSCKHAGVPGVKPERYEEGLVVKHCALSLVGEPIMYPEINKFLRL
LHNQHISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALAEKGVTYCGESSASNLTMANVPWHDEVVRFVEELADLLPDYEVACEHEHSNCMLIAH
EKFKINGDWWTWIDYERFQELIRAFDESKGSQKFTAMDYVAKTPEWALFGSRERGFDPLD
KRFQRKNKTKDISGC
>A0A2G9MZU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG11_big_fil_rev_8_21_14_0_20_47_5|TrEMBL
MGQNPACPKTIPPEVFSELCSQGYHIVGTHSANKRCMWLRECLRGGEFCYKHKFYGISSH
RCVQCTPVLLFCNHACKFCWRIMPEAKEKFEEMPTASFKWDSPQEIAEGLLKAQKDIVSG
YGGNEKTTAKLCEESRSPKHIALSLTGEPTLYPYLGELIGEFHKRGLTTFLVTNGTTPQA
LQALSSLPTQLYISMAAPNKEIYLQTCRPQTPSLWENYCKSLQLMGGKRIREGTRTVLRM
TLVRSLNMGGIDGYAKQIAIARPMFVEVKSYMHVGKGREKRGLALGDMLSMQEIWEYAQN
LAKLTGYLYTDEHPISRVALLCRDKKAQKGRFLKV
>A0A8H4TLN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium gaditjirri|TrEMBL
MGWANYSSPSRLDSFIDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKA
YEEPPKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEGEKDLARPVAPL
VFFSSITTRTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVEEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIRKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGDWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>D8U172|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Volvox carteri f. nagariensis|TrEMBL
MDFFAWLTLIIKTSWLFGLAFVFLQLWRTSGPRSISPKANVAKLSSSDLDQKTLQSSATA
AAETVATRNECCAKGEGTPPAGTDCRTAHRPATREPVAAVPPPALAPPVRVLYGSTKGTC
KQLATQLAERLSAVLSPLPAAVTAPAAAAAGAAVTACVVAAVDISCYDPEQLLSEPSGTL
LVVVISTYEGGSPPDSAKFFCSWLEEASSDFRLGAAALAQLRFAVWGCGNSLYEERFNVV
ARRVNRQLRELGARMFGRLGLGDEDVTAGGGDLSLQFAAWCEELVASEATWRGHGQQQQQ
GGGPGAAGDAAQGQEEQEEEEEEEEEEEEEEEEEGAGSEVDMEDIGGAGPRRGGRAGKEK
TPQTGPSATAGAEGGGGGGPPEMLNPLIRSSLTKQGYKLIGSHSGVKMCRWTKSMLRGRG
GCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKTWKWRMDGPQMIVETALDL
HTRMVREYSGVPGVKQEAVAEGLQVTNAQFPDRIQQLKPVTQLYVSVDAATPESLKAVDR
PLFSDYWDRFTSCLSALAAKKQRTVYRLTLVKGWNMSEVSSYAALVDLGRPDFIEIKGVT
YCGAGAASSLTMANVPYHADVVEFGQAICAARGGEYALACEHAHSCCILLARVDKFLLGG
QWHTWIDYDKFQKLVKQGGEFSAEHYMLPTPPWAVFGSQEAGFDPAQQRVRKVRRHPGKS
DSTAVSVAGEDAAEDF
>A0A640K820|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania tarentolae|TrEMBL
MMIVFLLQLLASLGLPLVGFLLYSHLADSAHTRSNTSSQQVQAKQEELKVASAPPPAAPV
QSLPPSTHMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLITAQLHTASPATA
DDVVCPLVRVMEMREDELSSKNNCRVDTLLEKNQYALIIFIASTYTNGAAPPQSQAFESM
LKDAFEDHRIPRNTLSRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGLGAPPFVVPPVY
ATEAKTQSLFRVFSTALLKWVSRATFHTDGTVTVKKKSEVAATCSSAASATETRRHKVGS
AAAAGNTCGKEGGSCACQQSSQQLCGSGASGDGEDGGACCMADTIADGVVSGKSDSDDDD
DNNAENDDMDDVEDLVWDGTDDADVDLSKDPSELPELLYPKLRQNLEKQGYRLVGSHSGV
KLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACANKCVFCWRHHTNPVSRHFRWK
QDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFC
DLLHKHHISSFMVTNAQFPEQLRDLKPVVQLYLSIDAPTPEELKRIDRPLFEDYWDRCLS
CVKELAKKQQRTVFRLTLVNQYNTENVKAYADLVEMGQPDFIEVKGVTYCGTSNSSTLNM
KDNVPRHDEVIGFCKALCDEMASRHPHYRTPQMDIEEEGGDDVIVISAEERNRPYHVACE
HEHSCCVLIALDKFFFDGHWHTWIDYERFYELVESGRTDFTSLDYAAVTPAWATYNSKEK
GFDPEQTRVVRKNARPTIVTASC
>A0A3P3Y2C6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodiophora brassicae|TrEMBL
MTGDDAVLILYGTRAGHARRVALKLQAELHRAGKISSMRSMAKFDPEDLVSHGRVLAVMS
TDSGGMPPPDARFFCQWLRDAVEDVRVPGDYLSGTRFAVFGLGDRAYEEQFNLAALNLDE
SFLKLRGRQLTAPFLSDGTDDDGDVSRWVKAVCIALDDAADGTAAADEAADDVVDVEDMG
SMMSTPTEGPGGRRPEMVTSRVRSNLAKQGYKIIGSHSGVKICRWTKAQLRGRGGCYKHT
FYGINSYQCMEMTPSLACANKCVFCWRHQTNPVGTSWRWAMDDPREILDGAIDRHCRMIN
EMKGVPGVLPDRLAEAYTVRHCALSLVGEPIMYPEINTLLGMMHERKISTFLVTNAQFPD
LIQTLRPVTQLYVSIDAADKDTLKAVDRPLFGDYWDRFLGSLDAIRESKQRTVFRLTLLK
GYNMDDVARYAQLVARGAPCFIEVKGVTFCGAGETSELTMKSVPFHHEVKSFCEALCREI
GDDQYDLACEHEHSCCVVIGHTKFKVDGVWHTWIDYDRFHELSQSGDAFSPTDYACPTPS
WAIYNNDEKGFDPNDTRHYRNRHRARPTERDTDGAAVFTPSPSTRPA
>A0A4Q7JHJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pochonia chlamydosporia 123|TrEMBL
MSAVCEKTDPLQGVFGVHPGTKFDEKDIVELWHGHRTPIIFCALIVLVAIRFYIHNVEDA
EPLKSIPKQFETKAIPGGTSKQSDMDVSEKTTAKSNGPRRIKGGVTKRPATKENDQYDKS
RPIKIMVFFSSVTTKTEKIARQYLSSLEHSVDQLSRETERQFLKPELHDLADIDFEDFFV
SPAKTADNAYLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLAPLLGYSVFGFGD
REGWPDEAEGYCFQAKEVDKWMSKLTGRKRAYPVGMGDMKSDHVDRFQEWTLGVQEVIGH
VARTGTLGEGVPGSGDAMESDAEDVAEEDDGEVLFEDDASSDDKESSRPLDDVEDLGRMI
RPSNGGRTANAANGKKAPLAVDFTSYGSSTKKRTPVAPVIKEMVAKNSPTYAALTKQGYT
IVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNP
VGTTWRWVVDPPDMIFAGVKEGHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIF
YPHINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHR
DFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTY
CGTSTSSNAGLSMSNVPFYWEVCEFVRALERKLKDKGLPYGIAAEHAHSCCILLASERFL
VDGKWHTHIDYKRFFELLEERGPDGEWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGR
KIENVVVREAPPPESW
>A0A6I8NT17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ornithorhynchus anatinus|TrEMBL
MSSEAAEPRPMRSRPPRPAPPPPEAPSPFPPARPGPDVPPGGRSGGTRGAVVCGSGVQRA
RGLPSPPPRSRPGGGPEALTSAKPTLAQDPQPVLWPTGRWVEGRPSLRLAAARRRLPAMD
AFSEPGSFIYTHSATLWRNRFYIYSCVALGLSLWFFFRLVSRKRGDQSRRKAAPARGSEA
TLPNGLAPLRNPDDRVAAVRIFYGSQTGTAKGFATILAGAAAALPSPVDVVDLRDYDPED
RLVGEAANGNVCVFLLATYADGRPPENATWFCKWLEEAAHDFRVGRTYLKDLNYAVFGLG
DSLYARDFNTVGRRVDRWLRMLGARRLLPRGEGDGNVARSARGSLEADFDAWRAGFLARL
RALRRGEPGEGRRTSWRTAGLDGGPPSDAQVPAGGGGWGATPGRESGRAGRGKPRGPVSP
GVGLRPARPLPVPGAPGPAPSGPIPSHPRRGGCRGGGAGSGRASAGGTASLLSLGVRDGE
EPAGSVGEDEESGTEEAPVPGAVVDVEDLGGVVAAVKTAKGGRERGEGGEPRAMITPALR
DALTKQGYRLLGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHANPVGTRWRWRMDRPETILQEAIESHQSMIRQFKGVPGVRADRFAEGMAVKHCA
LSLVGEPIMYPEINRFLQLLHQRGISSFLVTNAQFPAEIRTLGPVTQLYVSVDAGTEAAL
KRVDRPLFKDFWRRFLDSLRALAAKPQRTVYRLTLVKAWNVDELRAYADLVSLGEPDFIE
VKGVTYCGESSASSLTMANVPWHEEVLHFVRELASLLPNYDIASEHEHSNCLLLAHTKYK
IGGEWWTWIDYDRFQQLVRKHELSGGTETFTAADYVAKTPPWAVFGAKERGFDPRDIRFQ
RKNKAKEASGC
>A0A4Z1H9X4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis hyacinthi|TrEMBL
MPYDSWISRPIWSYEIDDVVALWHLYRIPIILTTATILILVRITLRPRTVREKLSASPLP
SSPVLPAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQAGPEKIQPLVFFSS
LTGTTEKTANSFVESIRGDLSGRAIGQKIQFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEDEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTTGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGEDKVAENSTKDDLAF
>A0A7J4BA88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MSRLKNQKYHLIGSHSAVKKCLWVHNALTQGRFCYKCKFYGIESHRCIQFTPATLWCWNA
CLHCWRVRPQDLGLRDEDLMRLPSVDDPEVIADLAIEEHRRTVSGYRNVAPKIMWEEAMN
PKHVAISLTGEPTLYPRLGELIEVFHGKGLTTFLVTRGIRPEVLASLEEEPTQLYVSLEA
WSREMYNFFNKPLVSRGWEKTLETLELLPSFSSPTVLRITLIKGFNMSEEDVRGFAKLID
KASPTYIEPKAYMHVGGSTERLSRDNMPSMNEVLDFAGRLANETSYRVASYSIPSRVVLL
TRLAGPIIRYGKGCPEAWRTEEVGDEFSGEYGVTDF
>A0A7C4JPE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MHLESERLQKAGYRIIGRHSAVKVCHWTKKSLLDRGVCYKEEFYGRELGIKSHLCLQMTP
ALWFCDHKCVHCWRDTRVTSSVWEGEPDDPSLILDLAIRAQRELLSGFGGNPVVNRKKFE
EAKNPKHCAISLAGEPTFYPKIAELIEECAKRGMTSFLVSNGMHPKVLEKIPSPSQLYIS
VLAPNEELYRRLCSPLIQDGWNRLLQSLDVLRSFKGRTAIRITLIRGMNMDDPAAYAPLV
IRAEPDFVEVKGYMWVGYSRSRLKLENMPSHADVTSFANELSSATGYQISGEQPASRVVL
LKR
>A0A8J7YII4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Sysuiplasma superficiale|TrEMBL
MDPQRKAVLEKQHYKVIGEHSAVKICHWTRESMLRDRGCYKQSFYGIESHRCMQMTPAVN
QCSENCQFCWRFQDFQEDHIEVEDDPEFILEQSIQAQKRLMSGYKGDARCSAEKWEESQK
PKHVAISLTGEPTAYSRLGEYIELCHRNGMTTFLVTNGTNPDVLRKLEPLPTQLYVTVAA
PTKEIFTKICAPIRSNAWEQLMETLSILPSLDTRKVIRHTLVRDWTLGFEETYSKLDAIA
EPHFIESKGYVHVGYSRERLSISNMPSHAEIRHFAERLGGLLGNYEIQSEREDSRVVLLV
RKGVDRWLPGLKRPLDEEIRYNRSANAVTV
>A0A1J3H7J7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Noccaea caerulescens|TrEMBL
MAASSSLRARLAFVVLLSATTFYCIHKYRRLKRLKNLSLNPSTPTSKASRGKIFFISQTG
TAKDLAQRLHELCAANDIAFDLVDPRSYEPEDLPKESLVIFIASTWDGGKPPQNGEFLVN
WLSESAEDFRVGSLLLSECKFAVFGVGSRAYGESYNAVAKELSSRMVGLGGLEMIPVGEG
DVDDGEVDSAFQEWCAGVIRALKGGSEQESNVVLQNGAVENDDEYIDTTDDEDDNNAEAD
IVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTK
SQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEI
VKGALDLHTKMIKQMKGVPGVTPEKLQEGLNPRHCALSLVGEPIMYPEINALVDELHGKR
ISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQE
KQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHA
DVKAFSEALSLKSEGEYEVACEHAHSCCVLLGRTQKFKKNGKWFTWIDYEKFHDLVASGE
LFTSTDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQAVLA
>A0A367I2J0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPAIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSETLNKVDSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NQEIFNRICKPKFDSHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDVMSFSNALAPLVGREVLSDRRESRVALIGK
EMIPVTLPEKTRDFPADLGIAKPQNFKLPSF
>A0A1L3Q188|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus halophilus|TrEMBL
MASDLLPDIGTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGISSHRCLQMT
PTLCCNQRCLHCWRPVELDVPIPSEWDSPVEIMGSSIECQRNLISGFGGSASRELWQQAN
EPAHVAISLSGEPTLYPYLDELVEEFRSRGVSTFVVTNGTVPEMIKSIKPSQLYMSLDAP
DRQTYMEVCSPKDPCLWDNINESLSILKDKECRTAIRITLIKGVNMFDVKGYADHIRKAQ
PDIIEVKAYMHLGFSRNRLGRDAMPGHEEVLDFANQLGCELGYEVADQVEISRVVMLCRD
ESVAASKLPV
>A0A534N4D7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDSEKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLACQFCWRTQEWGSDSLLLADDPTMIVEDSIRAQRELLSGFKGNPNVSRERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDEFQRRRMSTFLVTNGTTPAALRRLHSEGRLPTQLYVT
VAAPNETIYRTLVVPKSGHEWLKLKETLALLPTLPTRTVLRHTLVEGWNLGWEDEYAELD
RPAKPMFIECKGYSFVGESRLRLEANNVPSHASIRTFAERLGERLDYKIAAEREDSRVVL
LTRDGELHPLSR
>A0A1D6L6E5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zea mays|TrEMBL
MPPFPAATTTSHLALLVLFSSSSLFFLYKSLRLRRKPSPARTATPTLLFASVTGTSKTLA
ARLSARLTADAGFPVRATDAATFDPDDLPSVHLLLLVIPTHDGGATPPSAAFLSRWLEES
AADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARNFSRWLRALGAVEVVPLGEGDIDSG
DLEAVFEEWNRRVLRVVKGEEVGYGANEKNNGLDELELEGEDWDDDDEEMVDAEVDMEDI
AGKAPARRKNGNLEGVLANGVHNGVKDMVTPIIRTSLEKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDDPLDIVN
AAIDQHTKMVKQMKGVPGVKPEKLDEGLSPRHCALSLVGEPIMYPEINALVDELHRRHIS
TFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSLHEKD
QRTVYRLTLVKGWNAEEIDAYAKLLDLGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDV
KEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELVTSGKPF
NSRDYMAMTPSWAVYGAEEGGFDPDQSRFKKERRHGTAALRS
>A0A813Y7J8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta ricciae|TrEMBL
MSVDLYLFAAGSALTALLFYAFIGVQWSIWHMFTIPLYIIIFLVFSSLSALKRFKSSVKS
KTPRKPIVQEKNGITIAFASVKGNCRTFAQSTYDKLSNDLTRQVILQDLADITDPEEFLQ
TQAKNQRTLLIFISTYEDATPPPSAKWFLMHLQEAATDFRVSKNELEKLTYAVFGCGNSL
YRDNFNKVAKEVDRCLAEIGAKRLLPTELADENTVKSTYGGLEGHYSKWTSQLKTALESP
KPEKCDCSNNNSTTCCQSTTNGEQATKNDSDDNEQERIESDDDDEAGGCKNGGDDVMDLE
DMGDYIENTSITKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAQTVCQGAIDNH
YKMINIFKGVPGVLPHRLAEGMQIRHCALSLVGEPIMYPHINELIDILHSKNISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASNLTMANVPWHEEVVTFVRL
LCERLPQYGLACEHEHSNCLLLANTKFQIDGKWHTWIDYERFHELAARHKATDGKESFTS
LDYMAVTPDWAVVGSNERGFDPQDTRWHRKATAKKDLSGC
>A0A8J7XKP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theionarchaea archaeon|TrEMBL
MHEELEALLKRQRYRIIGKHSAVKLCHWLRKSLLEDRFCYKQRFYGIKSHRCLQMTPSVT
ACTQKCLFCWRPVQFTENNLSQHDAPALIVEESLKAQQVLLNGYFGLLDRVSPAKLKESL
EPTNVAISLAGEPTLYPELSELIREYKRRGMTTFLVTNGTSPHVLETLELPWNLYLTLAA
PTESCYKKLCHPQTNGWEKIMESLTVFSKLETQRVIRLTLVKGFNLTNPREYSQLIEKAS
PDFLEAKAYMYVGYSRHRMTIDNMPSFGEIMEFAREIEKYSSYEISDFQEASRVVQLKRI
>A0A075HLH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine group II/III euryarchaeote KM3_72_H01|TrEMBL
MQSPITRIEPKIAARLSKQKYQLVGEHGGVKVCHWTKQSLINDRSCYKGTFYGIESHGCM
QMAPNVDTCNLACTYCWREPHSDTLHKIDDDPYELFLESVRGHRRLITGYGGNPKADPEK
FREAQNPKHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDPLPTQL
YVSVDAPNKEIFDRLCKPKFDQAAFHKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDY
ARLDNIADPDFIEAKGYVYVGNSRNNLTIENMPYHQDILDFSNRLAPLVGREVLSDRRES
RVALIGREMVPITLPEKVRELPKNLGIAKPQQYVLPQA
>A0A2I0BU36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum (isolate NF54)|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDTSNTNDTNN
TNNTNIMNNTNNTNIMNNTNNTNIMNYTNNIRTGENCVSESETSSNQSYPDDEDEQIEVE
DLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSY
QCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYG
IIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPQELENLNT
VTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMEN
EIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINKKKALSH
IYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVETPHWAI
YGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A671PI08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
DPLFYIDLCKLYSRAFTGVLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGVCFTMNMLFK
KKKTVDPVSPWLYKSAKKQDLSAETEKVIHVSGVKVFYGSQTGTAKGFAKELAGDVSAQG
IQCDIIDMKEYDPEDRLTEECTSKMICVFLVATYRDGQPTESAEWFSKWLEEASTDFRYG
KTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSV
QADFQAWKMKFLSRLQALAKGEKKACSGKCKNGSCKNKKKHKKEAEDSHSLEELMESSSD
AESSSEEEKSHGSVIDVEDLGNVMNHMKKAKVKTKPAPPTLYIARYKLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAE
KIIQEAVENHRNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQ
QNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRSL
GEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPW
HEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDREWWTWIDYERFQELIQEYE
ESGGTKSFSAMDYMAKTPSWAIFGAQERGFDPSDTRFQRKNKTKDISGC
>A0A2L2TF68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium venenatum|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFATCIILVAVRIYFQFNGQKTEVVAFKKA
YEEPAKPKVVVEEVKVEQVQIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDLTRSVLPLIFFCSVTTKTAKIAQEYAEKLGGKLDELSKRSGRQFLKPETLDLTEIDFD
DYFLTPYKAHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERMQEWAQGVEE
VIEYVARTGNLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTIQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKMNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A671Q508|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
HSLFYIACLSHQKLLCKLYSRAFTGALNDVWEFTESYLLTVWRNRLCVYTTAAVLIGVWL
TVNMLFKKKKMVDPISPLLYKSVKNQELSPETEKVLHVSGVKVLYGSQTGTAKGFAKELA
GGISAQGIQCEVIDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEA
SMDFRYGKTFLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVV
KSRHGSVQADFQAWETKFLKRLQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDTLFGFQ
EELMESSSDAESSAEEEKSRGSVIDMEDLGNVMNRMKKAKGDEEDSQRVKLSKQNGVRKS
ESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHR
CMETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKIIQEALENHRNMIRQFRGVPGV
HPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPV
TQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELK
AYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACE
HEHSNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIF
GARERGFDPSDTRFQRKNKTKDISGC
>A0A822IGZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MKEMTSLPETTKTILKKHGYHLAGTHSAVKTCLWLNKSIRNTGACYKSRFYGMASHRCIQ
MTPTLVCNHRCLHCWRAVEVPVEVPPVWDSPKDIVKGVFDEHKRLISGYGGSEFMDKTRW
KEAFSPKHVAISLSGEPTMYPYLPELIGEFHKNDMTTFVVTNGTIPDMVEKIKPTQLYIS
LNAPDENTYGKACSPIGNSWENIKQSLEILKRSGTRTAIRITLTKGVNMVDPEGYARLIE
LAQPDYVELKAYMHLGFSRKRLSQDNMPSHEEVLGFSRQVAEALEYRIADDSSGSRVVLL
SKDGRKQNI
>A0A6P3GWJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bison bison bison|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
CLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALRKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHQSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSVIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>A0A7K7KQS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Asarcornis scutulata|TrEMBL
LDVSMDMWNFSYTCLASLWLHRFCIYSVIAFGISLWIVVQLFTTKKKGEKSNGNLSSEVV
EEKQANGYAAQQAKEVYVAGVKIFYGSQTGTARRFAKGLAEAVISLNLPVEVISMGDYDP
DDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLS
CLQALCRGERKPCSGKCKKGKCKSQGKQSKESSDHEHGASDYENAEAELVETTSEEEADA
EEAGGTNSVIDVEDLGNVMSHMKKAKVPLLQQLFQAEIDHLIYLLSSGYKLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMD
QPEMILQEAIENHQNMIKQFKGVAGVKADRFEEAMTAKHCALSLVGEPIMYPEINRFLKL
LHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSL
KALSEKQQRTVYRLTLVKAWNVDELRAYADLVSLGKPDFIEVKGVTYCGESSASSLTMAN
VPWHEEVVRFVQELVELIPDYEIACEHEHSNCLLIAHKKFKVDGEWCTWINYERFQELVR
EHERSGGSKTFTAADYTARTPHWALFGSSQRGFDPLDVRYQRKSKAKDISGC
>A0A3B5LPT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xiphophorus couchianus|TrEMBL
RSVIGQETAIGAPLILTLYFIYLCFILCCVSKSVCVFLVATYSDGRPTKNAEWFCKWLEE
ASTDFRYGNSFLKGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSAKRVLSRGEGDGNV
VKSRHGSVQADFRAWEVRFLSRLKALARGEKKSCSGNCKSGASCKNRKKHGAQEEEENGS
EKNKRFFFLFQVELIESSSEEEESGLSGEKMSRSVVDMEDLGNIMNNVKRAKVRFHPRSK
RLFELHMLEKMCDQVKSFFSILLKLLLLLVSRFVSNRHHTNPVGTEWRWKMDPAEKILQD
SLEKHQNMIRQFRGVPGVKPERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHHISS
FLVTNAQFPEEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQ
RTVYRLTLVKAWNVEELQAYAELIALGQPDFIEVKRLFPTGVSSQASLTMQQVGFIFSSN
FKVNGEWWTWIDYDRFQDLVQAHEDSGGQQSFSALDYTAKTPSWALFGSNEQGFDPADTR
FQRRNKTKDISGC
>A0A6P4XSC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Branchiostoma belcheri|TrEMBL
MAGRRDTFLVAVLCGNVVMLLAGVVLAPETTTADRRDMYSLVQWLWGLLLNMPTAVVLAM
VVNLLLLLRLVYTRGNSKEQVVYVNKDVACYKTSTQDIPTPHLRIFYGTQTGTAKHFAEL
LHTAAQDRGLTCGVTDLAKVTDPEDTFTEEMEAGSICVFILSTYTDGQPPEAAAWVCRWL
EESATDFRVSKTLLGKLQYAVFGLGSSEYGDNFNKASKKLEQWLKTLGAQEVFPRGVGDQ
NVAGSRHGSLEQDFTVWSNQMLGAVRNCQSQQGGCCKQSTDSCQCKGSDNKQGEDKEVQY
ESSSDDGGSLSDDDGALVDVEDLGAVMSKMKQAKKQRQEEEEAAGRGRRKITVKKKGGEP
KEMITPALKKALEKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDDPQAILDGAMKNHYNLIKQFKGVPGVKAERLA
EAMDVQHCALSLVGEPIMYPQINTFVQLLHRHRISSFLVTNAQFPDAIRNMDPVTQLYVS
VDASTKDSLKKIDRPLFRDFWPRFLDSLKALSEKGQRTVYRLTLVKAWNVDEIENYAQLV
EIGKPDFIEVKGVTYCGESKASSLSMANIPWHEEVVNFVQQLADQLPAYEIAAEHEHSNC
VLLANTKFKKGSEWWTWIDYPKFHQLIADYTDSEGDKMFSAEDYMAKTPGWAVFGSREQG
FDPQETRWYRKNRKDISGC
>A0A672UUH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Strigops habroptila|TrEMBL
MDTWSFFSTCLVSLWLHRLYVYSAVAFGITLVSQGEKPTGNPNSSEGVEDKLVNGCATLQ
AKEVYVAGVKIFYGSQTGTAKRFARALAEAVISLNVPVEVISIGDYDPDDCLLEETTSRN
ICVFLVATYTDGQPTESAAWFCRWLEEAANDFRFEKTYLKGLRYAVFGLGNSVYVDHYNT
VGRNIDRWLWMLSASRIMTCAEGDCNVAQSKHGTIEADFEAWKAKFLSRLQALCRGEKKP
CSGKCKKGRCKSPGKQSKESSDHEHGASEYENTEAEALFDTSSEAEADAEEAGGTNSVVD
VEDLGNIMRHMKQAKRERELEEGDVGMSLTRENAGRKEEGGKREMITPALREALTKQGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPEMILQQAIENHQNMIKQFKGVAGVQAARFEEAMTAKHCALSLVGEPIM
YPEINRFVRLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFK
DFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGK
SSASNLTMANVPWHEEVVHFVQELANLIPHYEIACEHEHSNCLLIAHKKFKINGEWCTWI
NYDRFQELVRAQEQSGGSQTFTGADYAARTPHWALFGSRERGFDPLDVKYQRKNKARDIS
GC
>A0A6A8RJU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp|TrEMBL
MKTSLTEGEIKSLEKKGYRFAGKYKHAAAKVCHWTKKSLVDEGVCYKEKFYGIKSHRCLQ
MSPSIPFCHHKCSFCWRDTSITKTEWNEDFDDARTIIDDCVEAQRNLLCGFFGNARVNNK
KIKEAQDPTNAAISLAGEPMLYPDINELISEFNRRNFTTFLVTNGMTPDKLENLEKEPAQ
LYISLDAPNKDYYNEVCQPQIIGGWELLNKSLELMKSFNSRTVLRTTCVKDLNMQLPEEY
AKIITKTDPDFIEIKAYMYVGSSRDRLTFENMPSNREVLDFAETVAALCGRKVKDHAHES
RVVLIE
>A0A1I0AU54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcoides vulcani|TrEMBL
MHQMSLKEKEELMTIPEIPDFEALLKKQGYSLAGTHSAVKTCLWLGRSMKGEGDCYKSRF
YGITSHCCLQMTPTLRCNQRCLFCWRPTEAEVSFPKDWDSPVEIVGSSINAQRKLISGFG
GSAPRERWEEANQPKHVAISLSGEPTLYPYLPELVKEYEKQGFTTFVVSNGTVPDMMERI
EPSQLYMSLDAPDRETYEKVCKPKSAELWDNINRSLEILGKKNNRKAIRITLVKGMNMID
PAGYARLIEIADPDYVEVKAYMHLGFSRSRLPREAMPSHEEVVSFAKELADHLGYSIADE
VEVSRIALLSKDGKVSYLD
>A0A6V8E793|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPMDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDAVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSDEHIQQFAALDN
RADPDFIENKGYVYVGHSRENLAMENMPTHDDIMDFSNKIAPLTARTVLSDSRPSRVALV
GTSITPIPVPEPTLFFPEDLGIAPSVKHLPVVS
>A0A6V8EBM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGIASHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVAREKWLDAQNP
KHVAISLNGEPTLYRRLGEYIDLCHKHGMTTMLVTNGTFPKVLERLDPLPTQLYVSVDAP
NKEIFNKVCKPKWNSRAWEQFEKTIDLLPSLDTRIVARHTLMKGINMSDRNIREFAALDN
RADPDFIENKGYVFVGNSRENLSAENMPSHDDIMEFSAKIAPLTGRKILSDSKPSRVALV
GQQITPIPIPKPTMFFPEDLGIAPPVKHLPIIQ
>A0A168IXB4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor lusitanicus CBS 277.49|TrEMBL
KIIFSTLTGTAKTMAAEIENKINTNERVTVNKIEVMDVTEYDNDNLLQETAVCVFILSTY
NVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAANIDKWLGRL
GATRIYPLGECDKNADQKGQFDVWSNGFVSELEDKHSLEFSPTNIAFQSDDEDDEASAEE
EEQQPDIDIDGSGSGDEMVDLEDMGNMASKIKAAKAKRNKPKTAPQAREMVSPMILKNLT
KQGYKVIGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSLACANKCVFCWR
HHTNPVGTTWRWKVDDPQFILDGAMENHYKMIKQLKGVPGVKAERFQEAFTIRHCALSLV
GEPIFYPHINEFVTKLHENNISSFLVTNAQFPDKIAEMVPVTQLYVSVDAATKDSLKKID
RPLFRDFWERFLNCLEQLALKGQRTVYRMTLVKGHNTAEIDGYVELIRRGKPSFIEVKGV
TYCGYSGASDLTMANVPFHVEVIDFCQKLVSKLDGDYEISAEHAHSCSLLIAHKDFKVNG
EWHTHIDYPKFFELVKSGKPFNSLDYMAKTPDWALHGHEAAGFDPNETRHYRKNR
>A0A504X923|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania donovani|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTAPPAAAEDVICPLVRVMEMREEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGVA
PPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGLG
APPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAASA
TEARSCKGGSATLATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCAK
DPSELPELLYPKLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQC
MEMTPSLACANKCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVT
PERLAMAMQIRHCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRNLKPVV
QLYLSIDAPTPEELKRIDRPLFEDYWDRCLSCVKELARKQQRTVFRLTLVNQYNTENVKA
YADLVEMGQPDFIEVKGVTYCGTSSNSTLNMKDNVPRHDEVVGFCKALCAEMASRHPHYR
TPQMDKEEEGGGDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERF
YDLVESGRTDFTSLDYAAVTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTASC
>A0A7M3XJY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPNANREKFLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCRPKFDQGAFHKLEETLRLLPSLDTRTVCRHTLIKHESMGHHEDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEILEFSEKLAPMVGREVLSDRRESRVALIGK
EMIPIELPLPKKELPKDLGIAKPQRFLLPQA
>A0A662T6T7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Geothermarchaeota archaeon|TrEMBL
MTSRGSVLGKEKFEILRQILRKQRYHLIGTHSAVKKCNWLHKALAYNIPCYKQKFYGIKT
HRCVQMTPAVIYCTLRCVYCWRLQPEDVNISWNQLRPPKWDDPETIVEGSIHEQRRILSG
YKDWVLRGKLDKKTFEEAWNPNQAAISLSGEPTLYPYLSDLIAEYKRRGFTTFLVTNGTI
PKALEKLNEKPTQLYITLPAYNKETFLRVNRPLIKDAWQRLLDSLDLMPSMSTRTVIRLT
LVKGLNMKEPKKYAKLIERANPMFIEPKGYVHVGFSQKRLSRENMPTHVEIRRFAEELAE
ELGYYIADESPSSRVVLLSREKKVRKIGQ
>A0A8G1RII4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus fijiensis CBS 313.89|TrEMBL
MTDFSVDEGVLAFWHLYRLPLLLALVAAFTFIRFYRTLQPKSRTATASSIPPSPRSHSPE
KSEKIAIGYDEEVTKVEKSAIQTIAEKEKAPKTTSGPKRVSGKKPSKVAGRRAGSDQEQQ
PLSFIQPIIFWASLTGSTEKYAQVLLEDLRAAAQERADPENRERAILPPQIHDLSYVDFD
DYFAAAPKPPSNSPGTRYVYCLLIPSYNIDTILNTFLGHLDETHNDFRIDTAPLSSLAGY
AVFGFGDKEGWPTEEEGYCSQAKELDRWMAKLTGRKRAYPLGFGDVKGDAEAALKEWSHG
LQDILGDILEHGGLGEGVPGSGDPLESDEEDLDEEGSDDSSKKNRKRNKAQDVVDLEDIK
FSADGQSGSGAPVPVDFTTAGASPASAIQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWK
VDSPDLIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINQFL
DMLHSERISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLDILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAG
AGLTMQNVPFYEEIQEFVTSLNKELERRGLKYGLAAEHAHSCCALIASERFYVNGKWHSR
IDYDRFFELLEKEKADGTPFKPEDYMSETLEWALWGNGGFDPNDERVYRKGKKKGLQAAA
AAQD
>F7EUZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca mulatta|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKV
QWLTPIIPALWEAKQVNHLRSGVQDHPGQCGETPSPLKIQKISQAWWHMPVVSATLEAEA
GESLVPGIQRLQ
>A0A2J2HEQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulcanisaeta sp. EB80|TrEMBL
MERTTQLIKEQLKYHVIGEVGGRVRLRISDETKVKLMRAGYGIYNHSTVELCHWTRSALT
QEQSCYKFKFYGAPAGGSHRCVEFSPVGMVCSNRCVYCWRPTDTFDSFTPNEGLVDDPEE
LIRGVLMERYRLLTGYFGHPKARERAREALTPTHWSISLSGEPTLYPKLPQLVRYLRGLP
STKSIFIVTNGEHPEMLERLQREDALPTQLYLSCNAPNRELFYRINVPVMYREDAWERWL
RSLELLSKVNTRTVIRITLIRSLNYDPRYIPEFAKLMVIGNPHFIEVKSYMNLGHSVYRL
SRGDMLTHEEVRDWAMKLLDEINRQGGNFRYMDEDPPSRIVVLQNMSRYVDRWIVKPEQQ
PGVLSEADKKKLEDALRKYGGPRVS
>A0A1V5SUY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon ADurb.Bin294|TrEMBL
MHSVQCDQSKKALRGMGYQFFHPDSSAALKPCLWCKRSLSGGDQCYKNQFYGITSHRCVQ
LTPTLRCNHTCLFCWRSFEHEYTGEKDLLPQEIVSRIPFLQKKALGGYKVSPKVTKEKWE
EALQPDQYAISLAGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPDVLKRCHPYQKYISL
TAPDRETYLRIARPREDYWDQVLESISCLGHETDAGDRTAIRVTLVRGINDQDPEGYARI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHDEIEHFTKRMLPHLSYRVLGENTLSRVI
CLERVS
>A0A2G8Y247|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii COUG|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
NQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQIRLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDERH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSANVSKECHTGAKPQGSSAAASAVGENSINEVERMCCRPATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKERGKTKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A3P6GE95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica oleracea|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLNPSTRRGKIFFISETGTSKSL
AQRLHKLLESNGVAFDLVDPTSYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSGCRFGVFGVGSRAYGEEYNAVAKEMSRRMVGLGGAEMVPLGEGDVDDG
ELDRAFQGWCDGVIRVLKGGSAQAQETNEITQNGVVESEDEYIDTTDEEEEDDNNDIVDL
EDIAGKAPSMKNGVVKVAKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVNG
ALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIST
FLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQ
RTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALSVKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFT
SRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>A0A3P9HHC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
AAPQTGSSLSENYLALLWHHRLYLYILGMFNFSLRLCFQKSGEKDAVLSGAIKQEEPEVH
VSGVKIFYGSQTGTAKGFAKVLSEELKALGFPAEVIDMKDYDPDDRLADECVSGSVCVFL
VATYTDGQPTESAEWFCKWLEDASTDFRYGRTYLKGLRYAVFGLGNSVYVGHYNTVCKNV
DKWLWMLSAKRLMTRGEGDCNVVKSRHGSIQADFQAWKGKFLSRLQALATGEKKTCSGKN
CKTGSSCKSKKEEEEASKETGSEVRRREEGVLLTVTELGKNGPQQDGEVVKFSKLNGVKK
IDDDDDGERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFYGLCWKHRSKLILTSSLLVTCLSGVPGVKPERYEEGLAVKH
CALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTKD
SLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYAELIALGQPDF
IEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAAMLPEYEVACEHEHSNCLLIAHKK
FKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDYMARTPSWALFGAREQGFDPADTR
FQRRNKTKDISGC
>A0A3Q7TTY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vulpes vulpes|TrEMBL
MDRFLDTWDFSSPVISLWINRFYIYLGFAFGVSLWICFQIVIRKQLFIFKGKKSQEKSVP
KATGDLMTNDCISLQNKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKE
YDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FLARLQALQKAEKKPCDGNCKRGQCESSVEEEPSESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEEQEKSSLVRNTVKNEDSERRTMITPALREALTKQGYQLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCALSLVGEPIMYPEINRFLK
LLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNS
LKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMA
NVPWHEEVIHFVREFVVLIPDYEIACEHEHSNCLLIAHKRFKIGREWWTWIDYNRFQELV
QGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>H0XFM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Otolemur garnettii|TrEMBL
VKSSCDLYKYYLSLPVFFWLQLSLLLSRPRLGXSLWICIQIIIKKQVSEDRNSREKSVPT
ASQDLMTNGYISLQKKEIFVSGVKIFYGSQTGTAKGFATILAESVTSLDLPVTIINLREY
DPDDHLVEEVTSKNVCVFLVATYTDGKPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAV
FGLGNSAYASHFNKVGKNVDKWLWMLGAHRVVTRGEGDCNVVRSKHGSIEADFRAWKTKF
IYQLQVLLRGEKKKSCSGSCKKGKCESNHHGSEEMEPGSHVQDDLHPRDTEEEELCESTS
EDEFGSENHQGLTSLVDVEDLGKIMDHMKKEKKEKEQQEEKTSLLRNTEKNEDGERRAMI
TPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGVQAERFEEGMT
VKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPVEIRTLEPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVALGN
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVSELVDLIPDYEIACEHEHSNCLLIA
HKKFKIDGEWWTWINYNRFQELVQEYEDSSGSKTFSTKDYMAKTPPWALFGAKERGFDPK
DTRYQRKNRSKDISGC
>A0A897NA97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halapricum desulfuricans|TrEMBL
MSDEGGPRQVGDPDYHSVNHTAVQTCGWTDNALQGEGKCYKYAFYGVESHRCMQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADATIDLQRKLLSGYGGNDDVPRERFEQAM
EPRHVAISLDGEPTLYPHLPELIEEFHDREITTFLVSNGTKPEMIERCDPTQLYISVDAP
DRKTFEETVKPVEEDLWERLIETLDVLAAKDDTRTVLRTTLVGGENDHRPAWYAAMADRA
DVDFFELKAYMHVGHSRGRLDRSSMLDHDDVVSFAREVQAFLPDHDHLVDVPDSRVAMLA
RDSDTWVPKLQQGSQFWADDPAAR
>A0A7C0ZPE7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIPKKLKEILEKQQYRVIGKHSAVKVCYWTKQSLKANRVCYKELWHHPVESHRCMQMTPY
IGCNFHCVHCWRLHSNDRPGLTWQEFPPPVKKWDEPGFIIDECIEQRKILLSGFGGHEKV
DKKKFEEALKPTMMTASLTGEPLFYPYMSEMVEEAKKRGMVMFIVTNGSLPEVLEKMDNL
PFRLYVSIYGPDKRTFIKVARPMIKDAWEKVNETLKLLPSLDTKKVFRILAIKGLNMRNP
KGYASLIKKSEPDFVEVKSYEWVGESQKRLPKEAMPFMEDVRDFAKKIADETGYEIKDEF
EPSGVVLLES
>A0A7C3SEG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MKKLRIDEETKKKLKNSKYGVFGHSTVEICNWTKRALRDEGICYKGKFFGIETHRCMEFS
PAGMYCQNRCIYCWRPTEFYKLLEMKEELVDEPEEIIQNLMNERRKLLTGFGSNKKVKKE
MLKEAYVPTHFAISLSGEPTMYPKLPEMIKYLKSLPQTKSIFLVTNGQEPKMLERLERED
ALPTQIYLSMNAGSKETFFKVNCPLLKDSWERFLSSLEFIRKTRTRTLIRITLIKEVNDS
EEEIPKFAELVKKANPNFVEVKSYMHVGSSTSRLKAENMLEQDEIKAWAEKLLKFLPNFE
YMDEQEESRIVILQNKERFVDRWIIKPKNL
>A0A093NFZ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pygoscelis adeliae|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYSAAAFGISIWIVIQFTTTKTKKKGEKSNGNPASS
EGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPAEAISMGD
YDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWRAK
FLSRLQALCRGEKKPCSGKCKKGKCKSPGKQNKESSDLEHGASEYENTEAEELFETSSEE
EADAEEAGGTNSVIDVEDLGDIMSHMKKAKRERELEEGDVGTSLTRENAGRKEENEKREM
ITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLG
KPDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPGYEIACEHEHSNCLLI
AHKKVRL
>A0A2I0PAE3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon HGW-Methanomicrobiales-2|TrEMBL
MRSEACKALKKQGYQFISPNSSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVTEEEECPPSAIIENLRRIQKRALSGYKVSPYVTPERFAEALA
PTMVAISLSGEPTCYSHLPELIDGLNTEGYTTFLVSNGTRPEVLARCRPYQIYVSLDAPD
RETYLHLCRPREDYWDRIHESLAGLAGRRSAIRTTVVRGYNDFSPEGYAAIYQDSGARFV
EVKGYMYLGYSRNRLQRDQMPEHHEVRAFAAKVTEHCDYFIRDESPVSRVVCLERDV
>A0A0K1E250|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum sp. WP30|TrEMBL
MSCEVEALGRYHVWEGPRIKIRASANRALIERHYGVAGHAAVELCKWTKDAIEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDAFMLDEQFYMEPEEVVKAVLE
ERRRLLSGYWGHPVGRRRVKEALEPTHWAISLSGEPTMYPKLPQLIKLIKSLPSTRSVFL
VTNGQHPEMLRRLVEEDALPTQLYLSTNAPNKELYYKINVPVYHREDAWERWLESLDILA
ATPTRAVLRITLIRSLNYDDKYIPEFAQIVKRGNPHFVEVKSYMHLGHSTFRLKKEDMLS
HEEVKQWAAKLLAELEKMGARFRYMDDDEPSRIAVLQNMDRYVDRWIVPPGN
>A0A833VEE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Carex littledalei|TrEMBL
MTTSLKIHIALLSVFSLSSLYFLLKSRRLRRLSLRSSPPLTWPKIFYLSETNTSKTLAHR
LHSFLLSNSLQFELTEPSLYEPDRLFNENLLLFVVSTWQDGKPPTSSQYFSQFLSDAASD
FRVGSLALSGCKFAIFGVGSASYGDTFNAAARDFSKWLKALGAKEILPVCEGDVDTGDLD
MGFDAWGVKVARVLKGEVEGESCTNGFDEELEEMVEIDEMEETGFGEVDIEDIAGKIPDK
NSLQGLHKGGRNGENGVKEMVTPVIRSSLEKQGYKIIGSHSGVKLCRWTKSQLRGRGGCY
KHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDDPLEIVNGAIDQHRK
MIKQMKGVPGVKQEQLDEGLAPRHCALSLVGEPIMYPEINSLVDELHRRHISTFLVTNAQ
FPDRIKILRPITQLYVSVDAATKDSLKAIDRPLFGDFWERFVDSLKALKDKAQRTVYRLT
LVKGWNADDIDAYSRLLSLGEPDFVEIKGVTYCGSTATSKLTMENVPWHTDVKSFSEALA
LKSNGVYEVACEHVHSCCVLLAKVNKFKIDGKWYTWIDYERFHQLVASEKPFNSKDYMAM
TPSWAVYGAGEGGFDPDQSRYKKERRHGTASLKTDSA
>C5DU29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)|TrEMBL
MRSNPVTAVATALCTGAYLWFGGRISVALAILVSYGIWHEESHKVVEEKPQLPLDGAEEK
TKKKHTCCGGKGGSGCCSSKNGDGGSAHACRCGSKKNKAVEEQKKDTDSYPVAVDFTQAF
KPEKKKKSRQPKVFSKSMPAKKQNEAPKQDNLVKSAMTVSNETLLNSQIYIFYCTLQGAA
ERCANKVMAKLCTMKELKHRPILLNLDDLSDIDDYFVNVPCDNALYLMVLPSYDTDCPLD
FFLQTLEENFHDFRVDRFPLKKLVGYSILGIGDSESWPERFCYQAKKADHWIARLGGRRV
FPVGEVCMKYDGEKKIEDWTNLFAETLKDDEPMLYEYDESVEEENENADGGEEMVDLEDI
GNADGNNSTEIKQMVAKNSPTYKTLTKQGYSIVGSHSGVKICRWTKSDLRGRGSCYKHSL
FNIVSSRCMELTPSLACSSKCVFCWRHGSNPVSKNWRWEVDDPEYILENALTSHYSKIKQ
MRGVPGVKAERFAKAFQVRHCALSLVGEPIMYPYISKFISLLHAKGISSFLVCNAQHPEA
LAKICKVTQLYVSIDASTKSELKKIDRPLYKDFWERLMQCLDILSTTQSHQRTVFRLTLV
KGFNMAEVMSYADLVQRGKPCFIEIKGATFAGSSDGNGNPLTMQNIPFYEEIKAFVRNFA
AELQRRGLGYDISAEHAHSNCILIANTKFKIDGEWYTHIDFDRYFELLNSGKDFQPLDYI
AKTPEWALFGNGGFVPGDTRFYRKGKKKGPEQAEPTPKQTVETAGSIEIA
>W4IVJ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum (isolate Palo Alto / Uganda)|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDH
QIFLSTIGNDEKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYN
DTSNTNDTNNTNIMNNTNNTNIMNNTNNTNIMNTNNTNIMNNTNNTNIMNNTNNTNIMNY
TNNIRTGENCVSESETSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIV
GSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVG
VKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYP
EINKLIDELHKRNISTFLVTNAQFPQELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDF
WDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGS
SQGYQLTMQNIPWHEEVYQFAWNLINKKKALSHIYEISCEHKHSCSILITKKIFKINNKW
NTWIDYEKFHQLVKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQ
S
>A0A7S3DFP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Palpitomonas bilix|TrEMBL
MGSVLSSLLSGVDGSVVVITVLLAVLAPLLLRSNKGGKKEETKKIDANQTQDEAKEGAKD
YRRTAAKERTQQVRRESKVFKLDSNGEGLDEVYILHGGMSGNCADFAEELGKNIHATGKV
SPTTVLSLEQFYEDGMTMKSLARKNAVCILIVATYTGGTPPPTAQAFFDYLEDSTHTKTE
LAGLRFAVVGLGHKDYATNYNVFGRYVDKRMAMLGAKRVYTRGEDDEAQLGEGFRVWQKA
FLSMLERAGFKKVAGAKSANAGSNGGSGRVKIGELQTEEEKKVVIEDPEESDDESAEESD
DDLDDLEDLGLEGEDGSGEAKEMVTESLRKNLTKQGYKIIGSHSGVKLCRWTKAMLRGRG
GCYKHTFYGISSFQCMEMTPSLACANKCVFCWRHHKNPVGREWRWKADDPKMLIDGAIEQ
HRGMMKQMKGVPGVKKDRYEESMNVKHCALSLVGEPIIYPHINEFVGYLHEKNISSFLVT
NAQFPELITALPPVTQLYVSIDASNEEDLKRIDRPLFTDFWQRFLDSIEALGKTGQRTVF
RLTLVKGWNMDELDGYAALVKHGNPCMIEVKGVTYCGGKKPVIGMKEVPWHDEVIRFCSE
LAKLLGDEYEIASEHAHSCCVLLARKDFKINGEWYTWIDFDKFAQLEREGKPFDTSDYLA
KTPYWAVYRGLGVDGDGGFDPAEVHMKRDGSIVESGC
>A0A7J3ELE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MSRLKNQKYHLIGSHSAVKKCLWVHNALTQGRFCYKCKFYGIESHRCVQFTPATLWCWNA
CLHCWRVRPQDLGLSDKDLMRLPSVDDPEVIADLAIEEHRRTVSGYRNVAPKNMWEEAMN
PKHVAISLTGEPTLYPRLSELIQVFHKKGLTTFLVTRGIRPEVLASLEEEPTQLYVSLEA
WNKEMYDFFNRPLISKGWEKTLETLELLPSFSSPTVLRITLIKEFNMSNEDVKGFARLID
KASPTYVEPKAYMHVGGSTERLSRDNMPSMNEVLDFAEKLAIETGYRVVSYSAPSRVVLL
TRLEGPIIRYGKGCPNAWRTEEIGDEFSGEYGQPESF
>A0A7L1B6N2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gymnorhina tibicen|TrEMBL
LDVSMDTWSYFHACLVSIWLHRFYIYSAVAFGISLWIVIQFTTARTKRKVGEDLLQELGA
DKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVVNMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTR
LQALCKGEKKPCSGKCKKEKCKSSGQQSKESSDHEHGMSEHENSEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKVLLLEGVWNALLGSEEVSGTCRHLGVGFLGCLMIFALFS
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALSVKHCALSLVGE
PIMYPQINRFVRLLHQRGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTY
CGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKFQVDGEWR
TWIDYGRFQELVRERERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKAR
DISGC
>A0A7S3VJ08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dunaliella tertiolecta|TrEMBL
MDLLQAAGFLAAPFALLSAASRLSLVTPEEPSHTAADTDEHASAAISASGCCQGGGREAV
NGHNCCKSEQAATSALKEGCSCTSGNAVSQQASGCGCASLGQPAAANSKGVQHVRILYGS
QLGTARRFAEQLAVACAAAGLPDVCCWDMAACDHEVLLSPPTTSSSSISTAHDCGDKNSS
SHNSTGAQHQQQQQGGGGGLAPGTAVLVVVSTYEGGSPPETAKWFCRGLEECSSDFRVGK
AALSHLYGFAVFGCGNSLYKELGNFNACALRLDAALSGLGAPRLGRVAMGDEDNGSMDTA
FKAWTSARITKLLQSLHGEDRRPKQQQQSQGGAASSSQGDDDDDEIEAEEEEDEMSEGGG
DAGSGGEVDMEDLAGRTGPAAHSSGPLSPRHGGGAGPRSSNRKKSRPPGGPAAPAGQGNH
QQPAVSAKDDSPPEMLNHVQRANLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFY
GIASHRCMEATPSLACANKCVFCWRHHTNPVGRSWRWAMDPADEIVARAVSLHRGMVREY
AGAPGVSAERVAEGMDIRHCALSLVGEPIMYPEINALVDELHARRISSFLVTNAQFPDAI
RNLRPVTQLYVSVDAATPETLKAVDRPLFADYWERFTECLRLLRDKRQRTVYRLTLVKGM
NMNDVLAYAKLLDLGRPDFIEIKGVTYCGDSPASGLTMEKNVPWHHEVVEFSQALCDARN
GEYALACEHAHSCCVVLARPDRFLRDGRWHTWIDYHKFHELATSGQPFTSEDYMLPTPSW
AVFGAAEAGFDPAEMRWKRTKGKGKALQPSEHGTDSASNPAATSTSTTAATGNNNSNSNG
GATASTHRTSFEARAAAHAAAAALPSGHISLSRTGSPKLPWAAHAPAPFPQQPLQASGPG
AAAAAAPAVRAAAAAAIEERAARANAARLAAAASQAAHATPRHQAPPAPTVAPV
>G0S6E3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)|TrEMBL
MSTDHPLSDRGRAPTAVISSSPPPSQPHNQALKKRTAQSRLQYQMNSSPPLAGRDSEESR
PFIGNQYGTHHDEFRQRQSETFLSSSGRVSWTYRNQWILLAISSGACAAFNGVFAKLTTT
ELTATLSKSVARGLGFESIEGWIELIVRAIFFALNLAFNGVMWTLFTAALAKGNSTTQVS
IMNTSSNFVITAILGSVIFSEALPPLWWVGAALLVAGNVIVGRKDEGGPKNLDRDQSLTA
SVLTSAGDGEMGPSSGGARNKLTPQVEMDEDEDIIDLRSLDGRPQTQKQTEKHEQQKQGP
KRIRGVPTKKGHGSPDPEVKTRRKIQVLVFFSSLTASTDKAARLFTQQLGKLLLCQASDK
SDSWFLEPKVLDLAEIDYDEYFITPPKSDGADVDFFYLLLIPSYNIDSINDNFLEHLKET
HHDFRIDTSPLSPILGYSVFGFGDSEGWPTEEEGFCFQAREVDKWMAKLSGRKRAFPLGM
GDWKRDAKDRLAEWQSGVVDVLRQLEQTGSLGEGVPGSGDPIESDDEREVGDDDEVFIED
GPELNSSSKSRGSDSLEDVEDIGRILELSQVDGSSGKKQGSKVPLAIDFTTEGKSSGTKK
LATTVKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSFYGINSH
QCMETTPSLSCSNKCIFCWRHGTNPVGTSWRWVVDPPDLIFNGVKEQHYKKIKMMRGVPG
VRAERFAEAMRIRHCALSLVGEPIFYPHINEFLRLLHAERISSFLVCNAQHPDQLAALQH
VTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILRERRFQQRTVFRLTLVKGFNIE
DEVEGYADLVERGLPCFVEVKGVTYCGTSTSSSAGLTMANVPFYQEVCDFVVTLEKALRK
RGLAYGIAAEHAHSCCILLASERFKVNGKWHTLIDYDKFFQLLEEKGPDGDFSPEDYMGP
PTPEWALWGNGGFDPRDQRVDKKGRPIEAAA
>A0A5N5P1Q9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coniochaeta sp. 2T2.1|TrEMBL
MALESTNWSPLTGPLVQDILQLWHSYRIPAIMVTFATLMVLRAYLHGTAEKPDLRVFPAK
EAEQKKPSSKPQKANALPPTQTAAKPKSAPRRIKGDVGRKSSPDRNGSGVREIQVYTFFS
SLTGNTEKIAREYNTKLESSLKAINPQEGESFSFLAPQVFDLAEADYDEYFISPPTVQTQ
NIGRPAEVFYLFLLPSYNIDTINDNLLEHLKETHHDFRIDTAPLSGLLGYSVFGFGSREG
WPTEEEGFCCQAAEVDKWMAKLTGRKRAFPLGMGDVKGDGIMRLEEWSEGVLDVLGMVAR
TGSLGEGVAGSGAPAESDDEEVEEEDDGEVLFDDELPTKPGKSKKGGDLGDVEDLGRIMQ
DSRPDGVDVKAPIAVDFTTYGKDSKGRAKTTTVTVKEMVPKDSPTYNSLTKQGYQIVGSH
SGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTSW
RWVVDPPDLIFSGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHIN
EFLGMLHAERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNRESLRKIDRPLHRDFWER
FQRCLDILRERRFRQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFIEVKGVTYCGTST
SSSAGLTMGNVPFYHEVCDFVKALDEALRRRGLEYGIAAEHAHSCCILIASERFRVEGRW
HTLIDYEKFFELLEAKGPDGDFTPEEYMGAATPEWATWGNGGFDPRDQRVDRKGRAIEI
>A0A2T7C0F1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panicum hallii var. hallii|TrEMBL
MPPSPTATTASATSHLALLFLLSSSSLFFFYKSIRLRRKPSPATATATATGPARTTIPTL
LYASATGTSKTLAARLSARLTADVGVPVNATDATSFDPDDLPSVPLLLLLVPTHDGGAPP
PSAAFLARWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAV
EVVPLGEGDVDGGDLEAVFEEWSGTVLRVVKGEELNEGVEGESDGLDELELEGEESDVDD
EEEAVSGEIDMEDIAGKAPTRMQNGKVEGGLTNGGQNGVKEMVTPIIRTSLEKQGYKILG
SHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGK
SWKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPE
INALVDELHRRHISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAVDRPLFSDFW
ERFLDSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSAT
SKLTMENVPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWID
YDRFHELVISGKPFKSQDYMAVTPSWAVYGAEEGGFDPDQSRFKKERRHGTAALKG
>A0A075GXY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_199_E03|TrEMBL
MIFSMSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRNEGSCYK
HKFYGISTHSCMEFSPAGMYCENRCIYCWRPMEFYDSMEMQPQNVAEPEEIMTKLMAERK
KLIMGHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVT
NGQEPDMIQKLQDENALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDT
RTVIRLTLIRGYNDDKEMIPAFTSLLRQSNAHFVEIKSYMHIGRSINRLEYSDMLEMDEV
RSFANKLTQENNTFTVMDESEISRIVILQNKKRFIDRFIPTYC
>A0A8C8YQ80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prolemur simus|TrEMBL
LDPSLDMWDLSSSLISLWINRFYIYMGLAFGISLWICVQIVIKKQGFATILAEAVTSLDL
PVAIINLKEYDPDDHLVEEVTSKNVCIFLVATYTDGRPTESAEWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSAYASYFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVGRSKHGSIE
ADFRVWKTKFIYQLQALCKGGKKKSCGGNCKKGKCESNQHGSEETEPRPHTPDELHPRDT
EEEEPCESSSEEEFGTEDRQGLNSVVDVEDLGKIMDRVKKEKKEKEQQEEKTSLFRNTGK
NEDGERRAMITPALREALTKQENYDKPRRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVQAGRFEEGMAVKHCAL
SLVGEPIMYPEINRFLKLLHHCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVRELAELIPDYEIACEHEHSNCLLIAHKKFKV
DGEWWTWIDYSRFQELVQEYEDSGGSKTFGAKDYMSKTPHWALFGASERGFDPKDTRYQR
KNRSKDISGC
>A0A6D2JTL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microthlaspi erraticum|TrEMBL
MAASSSLRARLAFVVLLSATTFYCIHKYRRLKRIKNLSLNPSNLTSKASRGKIFFISQTG
TAKALAQRLHELFAANDIAFDLVDPRSYEPEDLPKESLVIFIASTWDGGKPPQNGEFLVN
WLSESAEDFRVGSLLLSDCKFAVFGVGSRAYGESYNAVAKELSSRMVGLGGLEMIPVGEG
DVDDGELDGAFEEWSAGVIKALKGDSELETNLVLQNGDVENDDEYVDTTDDDEDDDNGEA
DIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKE
IVKGALDLHTKMIKQMKGVPGVTQEKLEEGLNPRHCALSLVGEPIMYPEINALVDELHGK
RISTFLVTNAQFPEKILNMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQ
EKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWH
ADVKAFSEALSLKSEGEYEVACEHAHSCCVLLGRTQKFKKNGKWFTWIDYEKFHDLVASG
EPFTSTDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQPQPQAVLA
>A0A0V1LII0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella nativa|TrEMBL
MMAYLTTHIRQGVSFFVPSKQSTFRKITINTMKTPCHVELYNTYNMWKAYYNMYERTLHV
FCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREEVKIFFASQSGNAQKL
AYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDGQCPEKCRWFFKWLEE
CVSDFRVEKSILSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLLKANNILPLYLTEDDN
FDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENENSSDAEDAENSANNVG
DIEDICERCVVMIHFTNVTNDSNKIKEMLTPTLRKSLAKQGYHLVGTHSGVKICRWTKSM
LRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPAEKILS
DSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMHSLNIS
TFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILREKK
QRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKVGVTYCGDSKDSKITMANVPWHAD
VVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAERFKKDG
ISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>Q4WM18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)|TrEMBL
MAEHSTAEGLLVFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSRESSNKATAQKAEQQPALANGSAKPTSGPKRVTGKKPSKVAGRRGQTEDAEPL
AFIQPIIFYASLTGNTERYAKVLLDELRVAAQKRADLRDRERGLLPPQIYDLSYVDLDDY
FTSAPKPPPTSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAETSLKEWSLGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDLLHGEHISSFLVC
NAQHPDQLHALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYADLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEREK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A4Q4SX96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus ibericus|TrEMBL
MSATFWESVADGNRGLTAVLFTVWVYLWLSQRQTKSAGSPKLESGKSLPTEFLAEEKVSL
LTAKESSSGPRRIKGELRKAEGPKSAVQLGPQQRVQVLVFFSSLTGSTERTAKQFTAALE
ASLLGQTSESDQVFLRPQLLDLTQIDYDEFFISPPKSTEANQPVDYFYLILLPSYNIDTI
NDNLLEHMKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQAKEVDKWMAKL
TGRKRAYPLGMGDSTRDSKERLAEWTEGVTEVVRQIAKTGCLGDGVPGSGDAVESDDEYV
SGEDDDGEVVVDEPLQPKKTKKSTRDIDDVEDLGRIMKTSRADANDATGRAPIAIDFTTY
SRTSKKPPQTVKEMVPKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKFSF
YGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGVKAGHYQKIKM
MRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLAMLHGERISSFLVCNAQHPEQ
LAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDILRERRFRQRTVFRLTLV
KGFNVEDEVEGYADLVERGLPCFVEIKGVTYCGTSSSGGKEGGLSMANVPFYAEVTAFVE
ALDRTLRERGLGYGIAAEHAHSCCVLLASERFRVGGRWHTRIDYDRFFELLEERGPDGEW
TPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A553IEW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xylaria flabelliformis|TrEMBL
MAMASNHTTDWGDPNPPRDFFEFWHVHREVILVVVISFFSMAYMIYTTLPTRRVINKTPK
RDVAATELASIKPAISGDEKSEVPLEALPPGVVARGPRRIKGELRKPEATRESSSSNSGR
RTQVLVFYSSLTTTTEKIANDFAQKLSASLVGYAAERKDLFFAPNVLDLAQIDYDEYFIS
LPKTADATTPIDYFYLFLIPSYNIDTINDNLLEHLQETHHDFRIDTSPLSGLLGYSVFGL
GDREGWPTEEEGFCFQAKEVDRWMAKLTGRKRAYPLGMGDKKLDLTDRLSEWMGGVMDVL
KLAATTGSLGEGVSGSGDADESDFEYASGDDDDEIVVEEAAAVPKKNGKKKTNIDDVEDL
GRIIKSSQAESNGSKEPAPIAIDFTTYGKSNTKRAPQPVKEMVPKTSPTYTALTKQGYSI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPEMIFEGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRD
FWERLQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYADLVERGLPCFVEIKGVTYC
GTSTSAGAGLTMANVPFYAEVTEFVTALDKKLKDRGLDYGIAAEHAHSCCVLIASGRFRV
DGKWHTRIDYQRFFELLEERGADGDWKPEDYMGPETPEWATWGNGGFDPRDERVDRKGRK
IEAS
>A0A8H7X550|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cadophora sp. M221|TrEMBL
MARDTWTLQPLLPFELADIVAVWHIYRIPIILTTVIALIIFRTYLHLRFPRHKITDTPPV
YPALPALREKPAPAEKKPVAEKVPRRIVGGLKKRKSSQEDIKPAEQKIQVLVFFSSLTGT
TEKTAKVFTEGLTQNTKKLGETTSDTFLEPEILDLSYIDYDEYFINPPKSDSGAQYFYVL
LLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQA
RDVDKWMAKLTGRKRAFPLGMGDTKKDAADRLAEWKEGVEDVLVHIAATGSLGEGVVGSG
DAVESDVEDVNEEEDVLFDEQKVAQRKTKVQKKEALNDLEDIGSTLNKTEIPEADLEELE
LDFTTYSKKPVSKAATVIKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRG
SCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFDGVKAG
HYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTTMLHKEHISSFLVC
NAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRERRFEQRT
VFRLTLVKGFNIEDEAEGYAALVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEV
CAFVEALNAALARRGLGYGIAAEHAHSCCILLASERFRVEGKWHTRIDYQKFFGCLESGE
DFRPEDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTEKQGEVMEI
>A0A7L0RYI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glaucidium brasilianum|TrEMBL
LGVSMDTWNFFYTCLVSLWLHRFYIYSTAAFGISVWIVIQLTTTTTKKKGEKSHGNPAAS
EEDKLVNGHATLQAKEVCVAGVKIFYGSQTGTAKRFAKSLAEAVVALNLPVEVISMGDCD
PDDCLSEETSSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGNMYLRGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
SRLQMLCRGEKKPCSGKCKKGKCKSVGKQSKESSECEQRASGYENTEAEELFETSSEEEA
DAEEAGGTNSVVDVEDLGNIMSHMKKAKVLLLEREGDVGMSLTRENAGRKEEGEREMVTP
ALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKAARFEEAMTAK
HCALSLVGEPIMYPEINRFVKLLHQRSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTK
ESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPD
FIEVKGVTYCGESSASSLTMANIPWHEEVVLFVQELADLIPDYEIVCEHEHSNCLLIAHK
KFKINGEWCTWINYERFQELVQEHERSGGSKTFTAADYTARTPHWALFGSRERGFDPLDV
RYQRKNKARDISGC
>A0A7K5THW9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Urocynchramus pylzowi|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIAIQFTTSRTKRKKSRGNPSSPEG
TADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKDLAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCRGEKKPCSGKCKKGKCKSSGKQSKDSSDHEHGTSEQDNTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNAAGAERREMITPALREALTKQGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEVILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHI
NRFVRLLHRHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSAS
SLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYGR
FQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDERVQRRNKARDTSGC
>A0A7L0XIS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tyrannus savana|TrEMBL
LDVSMDTWSYFHTCLASIWLHRFYIYSAVALGISLWIVIQFTTTKTKKKVTEPGEKSSGN
PTSSRGTEDKLVNGCATPQAKEVYVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVI
NMGDCDPDDCLAEETTSRNVCVFLVATYTDGQPPESAAWFCKWLEEAASDFRVGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRRVDRWLWVLGASRVMTRAEGDCNVARSRHGSIEGDFEA
WKAKFLTRLQALCRGEKKPCSGKCKKGKCKSPGKQSRESSDHEHGASEHENTEAEELFET
SSEEEADAEEAGGTNAVIDVEDLGNIMGHMKKAKVLLSLSSTEAAMLNPLGHPLVWFMSQ
LLQVNISSLLFCALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIQSHCCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILQEAIENHQNMIKQFRGVSGVKADRF
EEALTVKHCALSLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYV
SVDASTRESLRRIDRPLFKDFWQRFLDSLKALAEK
>A0A7J9QJC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilaceae archaeon|TrEMBL
MSCSGEVVDGEEQLIQIKPAITEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLDMLKHLNTRTVL
RITLIRGYNDQMDMIPTFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKRFS
EEVAKQSQIFSVMDESFVSRISILQNNERFIDRWIPTYANTS
>A0A371GX15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucuna pruriens|TrEMBL
MAIARLVRQAKRPHGLWVKMAAVTVLGLCFIFVWAVFSSSSSSVTSQRESFEDIAEPVSS
SPNKAQKLRDEFKKGESQNNNKNEESSRSSATHPHSEQHKGSDGNKDKKKVRKEDKDKGN
HHRGVEDPQHGHEEKDKEKEKEEEKGEEEGEEERVDRESEVDVDVDVDVDGGGDLAESVD
QEDGAVEEELRKPSKGKVKGPLFDPNASYRWKLCSSRSKHNYIPCIDIEVGGGKVLSYRH
TERSCPRTPLMCLVPLPHEGYGFPLPWPQSIFKILYKNVAHPKLAAYIKRHNWLMESGEY
LTFPQNQSEFKGGIQHYLESIEEMVPDIEWGKNIRVVLDIGCTDSSLAAALLDKEVLTLS
LGLKNDLVDLAQVALERGFPAVISPFSRRRLPFPSQVFDAIHCGGCNIPWHSNGGRLLLE
MNRILRPGGYFIMSSKHDSIEEEEAMTTLTASICWNVLAHKSDDVGEVGVKIYQKPEGND
IYELRRKKIPPLCKENENPDATCLHSIPSGIEQHGAEWPEEWPKRLESYPDWVNNKEKVV
ADTNHWNAVVNKSYLNGLGINWTSIRNVMDMKSIYGGLAVALSQQKVWVMNVVPVHAPDT
LPIIFERGFFGVYHDWCESFATYPRTYDLLHADHLFSRLKNRCKQPVTIVVEMDRILRPG
GWTIIRDKVEILNPLEEILKSMQWEIRMTFAQDKEVPARLTLLALFSATTFYCLYKSRRL
RHLKLSLYPNHNPNPNPNPKPKILFLSETGTAKSLAVRLHRLLASNDVAFDLVDSQHYEP
EDLPKETLLLLVASTWQDGGPPAASRFFATWLADASADFRAGSLLLSRCAFAVFGVGSRA
YGNEAFNAVARGLATHLRALGAKEVVPLCEGDVDGDDVDAVFNRWCEKVVAVLKDGGGVV
EDGDDVVAGECGVVSSSEEDSDVESSEIVDLEDIAGKAPSRKSVANGEESNGKLNGRREM
VTPVIRANLQKQGYKIIGSHSGVKICRWTKAQLRGRGGCYKHSFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGKSWQWQMDDPIEIVNSAIDLHTNMIKQMKGVPGVTLERLNEGL
SPRHCALSLVGEPIMYPEINALVDELHKRRISTFLVTNAQFPEKIKSLKPITQLYVSVDA
ATKDSLKAIDRPLFGDFWERFIDSLTALRQKHQRTVYRLTLVKGWNTEDVEAYSKLFSIG
EPDFVEIKGVTYCGSSTTSKLTMENVPWHTDVKAFSEALALKSQGEYEVACEHAHSCCVL
LAKANKFKIDGQWYTWIDYEKFHDLVASGRTFDSRDYMSATPSWALYGSEEGGFDPGQLR
YRKERHHKSNRNQSGLSVGFM
>A0A2T3AZQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amorphotheca resinae ATCC 22711|TrEMBL
MAHENWPQKALWPVEITDIVALWHTYRIPIILSTFTILIVFRTILHIRAPREKLSDSPPP
SSPNLPAEKEKLLVVDSKIPVAKAPRRIVGGLKKRSSSQEDARPREQKIQVLIFFSSLTG
TTEKTAKVFTEQLAKSQADSAIFLEPQLLDLSYIDYDEYFITPPKGEPGISYFYLLLLPT
YNIDTVLDNFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQAREVD
KWMAKLTARKRAFPLGLGDPKRDATERLKEWKEGVEDVLAHIAETGSLGEGVVGSGDAVE
SDVEDVDEDDGEVLFEEQEVAKRKSRLQKKDTLNDLEDIGGTLNKTPSAQNVESSAPLEV
DFTTYSKGGRPTAPPTAPAVTKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALR
GRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFNGV
KAGHYKKIKMMRGVPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFTAMLHKEHISSF
LVCNAQHPDQLAALKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRFQ
QRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFY
EEVCAFVEALNAALARRGLAYGIAAEHAHSCCILIASDRFKKNGKWHTRIDYEKFFECLE
SGKSFTPEDYMGPETPEWATWGKGGFDPRDERVFRKGKNKVALTGSQGEVMGEKEVVEID
S
>A0A4D9ER78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Platysternon megacephalum|TrEMBL
MATSRSGILNFWLVFQVLAACADAHAMDASMDTWSYFYTHLMSIWLNRFYIYSCAAFGIG
IWICFQFIATKAKKQDEKSTEKLTPSKVTQDVLINGYTMPKMKEVYVAGVKVFYGSQTGT
AKGFATILAEAILSLNLPAEIINMRDYDPDDCLAEEATRKNICVFLVATYTDGQPTENAA
WFCKWLEEAVNDFRFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMT
RAEGDCNVAKSKHGSIEADFDAWKARFLARLQALCKGEKKPCSGNCKKGKCKSKGKQSKE
GSDHEQRVSEQENTEVEDLFETTSEEESGAEEDGSRNSVIDVEDLGKIMGHMKKAKKECE
LEEEAGRTGPSQQSSGKNEESERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPETILREA
IENHQSLIKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSF
LVTNAQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQR
TVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVH
FVRELADLIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWIDYDRFQELVQEYENSRGSK
TFTAADYVVKTPHWAVFGARERGFDPLDTRFQRKNKTKDISGC
>A0A0E3SNE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina barkeri 3|TrEMBL
MEEKKENFGENSPEVREKNREEDAVLLPFDIPDFKTLLKKQGYALAGRHSAVKTCLWLRH
AMNDQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDSPEKIVEE
SIVCQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEKRGFTT
FLVTNGTVPEMLAKVSPSQLYMSLDAPDLETYLKVCQPRSPVLWEKINESLSLMKQKKSR
TVIRTTLVKGENLFKPEDYARLIEKASPDFVEIKAYMHLGFSRLRLDRSAMPTHEEVIEF
SQELAKHLGYKIADESEISRVVLLSKDGRKSSVNKKKISC
>A0A7T3FV36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halosimplex litoreum|TrEMBL
MSESDGPKQVSDPEYHSENHTAAQTCGWTANSLRGEGKCYKFAFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPSAVADASLELQKKLLSGFGGNDQVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFRDRDITTFLVSNGTKPEVLAECDPTQLYVSVDAP
DRWTFDETVKAVEDDAWERLIDTLDVLAEKDETRTVLRTTLVDGNNMHHPEWYASMFQRA
DPDFVELKAYMHVGHSRGRLDRDAMPDHEDVRAFTEDVMEHMPEHDYMNDVPVSHVTLLS
KTEDTWVPKLQKDSEFWERDPYAEAGD
>A0A1Q7X7Z4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_20CM_2_38_5|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPLDKVAPPDVIVTNLIEERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRIVVLQNQKRFMDRWIAAYANTN
>A0A6B0SXR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium bonnevillei|TrEMBL
MAESGGMPKQVDDPDYHHENHTAAQTCGWTANALRGEGTCYKHAFYGIRSHRCIQMTPVV
RCNERCVFCWRDHAGHTYELDGVEWDDPEAVVDASISLQKKLLSGFGGNDEVPRARFDEA
MEPRHVAISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEVLAECDPTQLYVSVDA
PERATFDDVVGATEDDAWEKLVDAMDVLYEKDETRTVLRTTLVGGENMANPDWYAGFYDR
ADPDFVELKAYMHVGDSRDRLDREAMPDHEDVLAFAEAVQANMPEHSVLKHQEVSRVALL
ARDHDTWVPKLEADSEFWADATAD
>A0A2J7QXN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cryptotermes secundus|TrEMBL
MLGIETRWFSFEVTEAATLCISHCPNMFTVLGIPLIGTLFLPTLLGVITFYIIWSLSTRR
KDSSCTGGLSSAAREPSDPMLAVNDLTSKPETKVFGNRAVSSPNLQSEDNSCTESDVYSV
TQIKVQYASNSRRKVFRSKAGDQCSQTVQVVSDLTKKNTRKKRCKGKPGCCSKKNGASTI
LEGTIETVKVFFGTQTGKSKIFSTVLAEGCEQRGLSSELVDLASADPEERLLEETSGNSL
CVFILPTYTEGKPPESAAWFYKWLQEASNDFRVEKELLKGMKFAVFGLGNSQYKAHFNEV
GKQVDGWLQELHAARLIKLGIGDEDTVASKHGSIEADFQNWNSQLWARVDKLRAACQCDA
TEQDQAESSCDSSSEGCYSDGDSSEQDSRGNGVLDLEELGSFSNSLLAARERKFEDNSPR
EMVTALLKESLTKQGYRIVGTHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDPPEQIMTEALENHYNMIRQFRGVPGVLPERFAE
GMDVKHCALSLVGEPIMYPEIGSFVRLLHERGISTFLVTNAQFPEALRDLSPVTQLYVSV
DASTKSSLRKIDRPLFKDFWERFIDSLKALSEKGQRTVYRLTLVKSWNADEIADYAKLVA
IGKPDFIEVKFKVNGEWWTWINYDKFHELMRQYYLTDGASTFTAEDYMCKTPSWAVFGAL
ERGFDPAEKRWHRKTLPKKDISGC
>A0A370TWG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Venustampulla echinocandica|TrEMBL
MDNVNGLFGPSWSLDTGDIVELWHLYRIPIVLASFTVLMIVRTILRLRKPREKLSETPPP
TSPSLPAEKTIAPLELTKKTSIEKIKAPRRIVGGLKKSKPSEDDIESGDKKIQVLVFFSS
LTTTTEKTAKVFTEGLAHNIKEFSSSATFLEPEILDLSYIDYDEYFINPPKSEPNTQYFY
LILIPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSSLLGYSVFGFGDREGWPTEEEGFCS
QARDVDKWMAKLTGRRRAFPLGVCDAKTDGPERLKEWKEGVEDVILHIAKTGGLGEGVAG
SGDAVESDVEDVDDDDDNDEVLFQEQDVAQRKTKAQKQDSLNDLEDLGRSLDKPSADPSP
PLEVDFTTYSKKSRKPEAPAIIKEMVPKNSPTYNSLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVEPPEMIFTG
VKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLAMLHNEHISS
FLVCNAQHPDQLAALTPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNACLDILRERRF
EQRTVFRLTLVKGFNIDDEVEGYARLVEQGLPCFVEIKGVTYCGTSTSSSAGLTMANVPF
YSEIQEFVLALTAALNKRGLGYGIAAEHAHSCCVLIASERFKNESGRWCTRIDYKRFFEL
LEKGEPFRPEEYMGEETPEWALWGNGGFDPRDERVYRKGKNKVPLPVKKEEEEIEDEVVV
VGGE
>A0A023F5Z5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triatoma infestans|TrEMBL
LNVYYSTQYGKTKALCEQLSSISAIKINIFDMAKVEAEEVLSRDANAPNIVSLIIIPTVG
DGKPPDNGSWFCKWLHEAATDFRIDKELYKELYYAVFGVGNSAYGENFNIIAKKIDTDLK
KLGAKRILPLTLGNEDASNSINGSLEADFKSWLQELKELIKNSEISSSWLTQKVSNEDSS
DEEENDKDNVVDVEDLVKITNNKESLKEKEMITPSLRQTLTKQGYKLVGTHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWKWKTDQAED
IVNGALRNHYNMIKEFKGVPGVLLPRFEEGLNAKHCALSLVGEPIMYPEINRLIRLLHER
QISTFLVTNAQFPEAIANLDPVTQLYVSVDASTEESLKKIDRPLFKDFWKRFLDSLKELS
KKGQRTVYRLTLVKAWNFDEMQNYANLVNLGNPDFIEVKGVTYCGGDNTGPNKLTMANVP
WHEEVVSFVQQLTSLLPNYEIASEHEHSNCLLIAHKXFYIAGQWCTWIDYDRFHVLMQSY
YKTEGNQNFTTLDYTSPTPSWAVFGARERGFDPIEKRWFRKSKKDISGC
>A0A8C5XFM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microcebus murinus|TrEMBL
LDPSLEMWDLSSPLISLWINRFYIYMGFAFGISLWICVQIVIKKQGFATILAEAVTSLDL
PVAIIDLKEYDPDDHLVEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSAYASYFNKVGKNIDKWLWMLGAHRVMTRGEGDCDVVRSKHGSIE
ADFRAWKTKFIYRLQALCKGEKKKSCGGNCKKGKCESNQHGSEETEPGSHTPDDLHPRDT
EEEEPGENTSEEEFGTEDHQGLNSVVDVEDLGKIMDRVKKEKKEKEQQEEKTSLFRSTGK
NEDGERRAMITPALREALTKQVNASRERRFHRCMETTPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEVILKEAMENHQNMIKQFKGVPGVQAERFEEGMTVKHCALSLVGEPIMYPEI
NRFLKLLHHCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQ
RFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSAS
SLTMANVPWHEEVVRFVRELVELIPDYEISCEHEHSNCLLIAHKKFKIDGEWWTWIDYNR
FQELIQEYEDSGGSKTFSAKDYVAKTPHWALFGANERGFDPKDTRYQRKNRAKDISGC
>A0A3M6W6A2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MGRVSARDVLSAAAACVMILSLSLPDAESRARRMSGSARFGEACALGIPSFVCLMVGFSK
VPLKVNIKRTEIPIAPGECTTARVATSIHPPPTMDMEKILQLPQELLFLWHAHRAEVLLS
AGLIFAILRLAVHWRTRKSKEVLTPPVLTPVDEKPLAVPSAKETLADADHYEEPTPKPTV
QRPKPGPKRVTGTKKSKSAASQEAQVIEKIQPIIFYYTLGGSTKVYAESVAQDLTTSSPS
SILEPQLHDLADTEYDDFFLSIPKAEKTAHFYLLLLPTYNIDTNLSNFLEHLQETHHDFR
IDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQAVDADKWMARLTGRKRGFPLGFGDVSK
KDEADVMLKEWTEGVSSIMKDLAEGKGLGEGVPGSGEPIESADEASEDEDETPTPRKSKR
KPAKRSRTDDLEDLKAPIPVDFTTSKPTSTTQPPPPKPMVPETSPTYSALTKQGYTIVGS
HSGVKICRWTKSALRGRGSCYKFSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTT
WRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVRAERFQEAMRIRHCALSLVGEPIFYPYI
NELLGMLHRERISSFLVCNAQHPDQLEALGPVTQLYVSIDASNKEMLRQIDRPLHRDYWE
RFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEEAEGYANLVETARPGFVEVKGVTYCGTS
TSKGAGLSMQNVPFYQEVTAFVLALEKALANRGLDYGIGAEHAHSCCILLADRERFYRIP
EAEKGNPAAEKKWHTLIDYPRFFDCLESGKPFSPEDYVGPPTPEWALWGNGGFDPRDERV
DRKGRPKEVKEVKVQEVQ
>A0A1U8CKV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mesocricetus auratus|TrEMBL
MGPPLDVWDFSSPLLLLWMNRFYIYLGCALGITLWICVQVVIKKQVIRSQEKSVPGAPDS
SLPLQKKQTHVSGVKIFYGSQTGTAKGFAVTLAKAVTSLDLPVAIINLKEYDPDDNLIGE
ITSKNVCAFLVATYTDGRPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQ
SHFNKVSTNVDKWLWMLGAQRVLTRGEGDRNAVQSKHGSIEADFTAWKTKFISRLQALQS
GEKKACSGDCKKGKCETTQPGAGEVRPHLQGGLRPGGAERERAQQEEKAGVKRNPETSVD
SEGRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIDSHRCME
ATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAE
RFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQHGISSFLVTNAQFPEEIRNLTPVTQL
YVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKCWNVEELQAYA
ELVSLGNPDFIEVKGVTYCGESAASNLTMANVPWHEEVVRFVQELVDLLPDYEIACEHEH
SNCLLIGHKKFKISGEWWTWIDYSRFQELVLQYEESGGSKTFSASDYMARTPQWALFGAR
ERGFDPKDTRYQRKNKAKDVSGC
>A0A512U5X2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metschnikowia sp. JCM 33374|TrEMBL
MAAMVWFHISRRSKAENMPQKPSPILEVDFTHAYMPSEKTVFPKSIPLSAKPKKVSRRAK
SPKIFKGTKTLKSVSESALTANPFKLLESPIYIFYTTLTGSSHRVAKTLYEKLSNIEELS
TPPKLLSLDDDVDDLEEFFLKTPKSSKPNIYLLVLPSYETDSPIDYFLEHLQETSQDFRI
DKYPLRPLAGFAVLGLGDSESWGGAKFCYQAQLADKWMGKLGARRLFPLGQVCMKHEGEP
KAHDWINRFAELLADDEPFHVNENDVIDDSDAEEESEIDPATDVVDVEDMGAIIKASNGS
LTMMEPKQMVAQDSPTFKSLTKQGYTVVGSHSGVKICRWTKSAMRGRGSCYKFAFYGIRS
HLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVDPPEKVLHGALEGHYKKIKQMRGV
PGIQMDRFEEAFRVRHCALSLVGEPIFYPHINEFVGMLHEREISSFLVCNAQHPANLEAL
AKVTQLYVSIDAPTKQDLKKVDRPLNSDFWERLIACLDILRTTQAHQRTVFRLTLVKGFN
MGDIKSYADMVERAQPSQIEVKGATFCGSSAGNGNPLTMQNIPFYDECKEFVESLVKELN
SRGQTYELAAEHAHSCCILIAHTKFHINGTWHTHIDYPKFFELLRSGQEFNALDYVKETP
PWALWGSDEAGFNPDDTRYDRKAEKLKKKEARDAQAAEAQAIQEAQVVHETQEV
>A0A3Q0RHS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amphilophus citrinellus|TrEMBL
PAESYLRWLWHSRLYLYSAAALVFGLWFLMKRVSHVLVPSKGLCNCSSSCCCLHLKTLHR
VFISAFRNASLKTGGGFANELSEEVQALGLPAEVTDMKDYDPDDQLADECVSKSVCVFLV
ATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYAGHYNTVGKNVD
KWLWMLSGRRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLNRLKALAKGEKKSCSGNCK
REGSCKNKETKASXQNHSSEDDLIESSSDEDEAGLPDEKKSVLDVEDLGNIMNSVKKAKV
RLSLPSSQMGLKRLSKLNGVQKIEDEGEGREMITPALREALTKQGYKLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKLDPAE
KILQDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHR
HHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRAL
GEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPW
HQEVVAFVQQLADMLPEYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAYD
ESGGQQSFSALDYMAKTPSWALFGAQEQGFDPAETRFQRRNKSKDITGC
>A0A6A6FTT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cercospora zeae-maydis SCOH1-5|TrEMBL
MDTSRLLGLPQELLLLYRAHRVEVLLSAGIVVAIVRLLVHWRSKKAKVLLTPPLGSSVHE
QPLKLVDEKTPASSDRPDTPPSESSRPKGPKRVKGVRTGKRKSSPTRAIDQIQPYVFYYS
LGGSTRAYAEKLASTIAASERVLTPIVHDLTEIDYDDYFISAPKQARSGTAAFYYVLVPS
YNIDTELSNFLSHLEETHHDFRIDDQSLSGLAGYSVFGFGDRQEWPTEEEGYCSQAVEVD
RWMAKLTGRKRAYPVGTGDVKGDDVDMRLEEWRRGVYNIMDDLGRGQGLGVGVPGSGDAA
ESGDEISEDEDDSTLDPAPRRSTKRITTDDLEDIKAPIPVDFTTTSIKKAPQPAVLKAMV
PKESPTYSSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMEATPSL
ACANKCVFCWRHGTNPVGTSWRWTVDPPDQIFQGMTAGHYQKIKQLRGVPGVRAERFAEG
MQIRHCALSLVGEPIFYPHINELLGMLHANHISSFLVCNAQHPEQLAALGPVTQLYVSID
ASNKHALRKIDRPLHRDYWERFTQCMDILREKRQTHRTVFRLTLVKGFNIDDEAQGYADL
VQRALPAFVEVKGVTYCGTSTSKGAGLSMQNVPFYEEVQAFVLALEEELQRRGLDYGIGA
EHAHSCCILLADKTRFWRPLAAGAGRYHTTIDYPAFFRCVESGGKFGPEDYVSEIPTAEW
ALWGNGGFDPRDERVDRKGRPKEVGEVKRVVEI
>I3M3J7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ictidomys tridecemlineatus|TrEMBL
MGPPLSLLSQSRQGPARPASPLGPPLSLRSGPARQRAAWPVTGLRVLACAAAEEQLSPGL
RAWAPRSMDPPLAAWDLSSPLLSLWMHRFYLYLGFAFGISLWICVQILIKKQGKSSQERS
IPEAAQDLMTNDYASLPKKHIFVSGVKIFYGSQTGTAKGFATILAKAVTSLDLPVAVINL
KEYDPDDHLVEEITSKSVCAFLLATYTDGRPTESAEWFCKWLQEASSDFRFGRTYLKGMR
YAVFGLGNSAYASHFNKVGKNVDKWLWMLGARRVLARGDGDCDAVRSKHGSIEADFRAWK
TRFISRLQALQKGETSCGGNCRRGKCESKQHGTEDKEPEPHSLAAQQPRDTEEEEPCESS
SEEEFGAGEHQGPNSVVDVEDLGKVMDLMKKEKREEEQQEEKVLFGSREKKEGREGRAML
TPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILEGAVENHLDMMKQFRGVPGVKAERFEEGMK
VKHCALSLVGEPIMYPEINRFLQLLHQRKISSFLVTNAQFPEEIRKLKPVTQLYVSVDAS
TKDSLRKIDRPLFKDFWTRFLDSLKALAEKQQRTVYRLTLVKSWNVDELQAYAELVSLGS
PDFIEVKGVTYCGESAASSLTMANVPWHEEVVRFVRELVGLIPDYEIACEHEHSNCLLVA
HRRFKIEGEWWTWIDYGRFQELVQEYEDSGGSKSFSAEDYMAKTPPWALFGARERGFDPK
DTRHQRKNKSKDVSGC
>U3T9H5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aeropyrum camini SY1 = JCM 12091|TrEMBL
MPEKWLPLAEVMVKQKYHFAGRHTVVKKCYWTHKALTEDRHCYKCKFYGIESHRDIQMSP
AAFWCWNACLHCWRIRPQDLGVDLDETKLTIVDDPKWLVDELIRIHRRLISGYKGHPKVD
PKKFWEAWNPVHVTLSLTGEPTLYPMLSDLLKEVHRRGMTSFLVTRGVRPDILANLEEEP
SQLYVSLEAWDKKSYNYFTRPLVPRAWELTLETLEMMPSFTSPTVIRITLVSGFNDTDEA
LKGFAKLINLAQPTYVEIKSYMWVGASRMRLSKANMAEHEYVRKVSERLSELTGYPILGE
SRASRVVLLSRLEKPIRLGKGCPEGLNTPEPEEGEYDAPYDPDIMP
>A0A8C9TVQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
RRRLQIILGLIFFCFQGFARNLAEDLHALDLIAEVIDLKDYDPEDSLSDECTSKAICVFL
LATYTDGLPTENAEWFCKWLEEASTDFRYGQTYLKGMRYAVFGLGNSVYTGHYNTVSKNV
DKWLWMLSAARILTRGEGDANVVKSRHGSLEADFGSWKARLLKRLEALVRGEKKACSGKC
KKGTCKSKGKGKVLEQSEHHSSEEQLMETSSDAESATGEEADHRSVVDMEDLGNVMNLMR
KFACFKSQRVPWCEPLGAFTQSLMAHVQLARLYRFSLLPFFFFLSSTGYKLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMD
PPEIILQEALQNHQNMIKQFRGVPGVRPERFEEGLTAKHCALSLVGEPIMYPEINAFIRL
LHRQRISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALGEKQQRTVYRLTLVKAWNVDELKAYADLISLGQPDFIEVKGVTYCGESSASNLTMAN
VPWHEEVVHFVRQLADLLPDYDIASEHEHSNCLLIAHRKFNVEGQWWTWIDYERFQEFAQ
LYEESGGQRTFSAEDYMARTPDWALFGAKERGFDPADTRFQRKNKTKDISGC
>A0A8C9U4B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
VFSPHCVHKIDQQFSSSKYLSFRYYLSFELSCFLWICKLTVLIIRSLLYFTHIGRLQIIL
GLIFFCFQGFARNLAEDLHALDLIAEVIDLKDYDPEDSLSDECTSKAICVFLLATYTDGL
PTENAEWFCKWLEEASTDFRYGQTYLKGMRYAVFGLGNSVYTGHYNTVSKNVDKWLWMLS
AARILTRGEGDANVVKSRHGSLEADFGSWKARLLKRLEALVRGEKKACSGKCKKGTCKSK
GKGKVLEQSEHHSSERVPWCEPLGAFTQSLMAHVQLARLYRFSLLPFFFFLSSTGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGT
EWRWKMDPPEIILQEALQNHQNMIKQFRGVPGVRPERFEEGLTAKHCALSLVGEPIMYPE
INAFIRLLHRQRISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFW
QRFLDSLKALGEKQQRTVYRLTLVKAWNVDELKAYADLISLGQPDFIEVKGVTYCGESSA
SNLTMANVPWHEEVVHFVRQLADLLPDYDIASEHEHSNCLLIAHRKFNVEGQWWTWIDYE
RFQEFAQLYEESGGQRTFSAEDYMARTPDWALFGAKERGFDPADTRFQRKNKTKDISGC
>A0A1V2LUD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pichia kudriavzevii|TrEMBL
MNEHIVALGAFAAFLYLAGKLGLLLLIVMCVGLMYCSKDVANGGDSVTRRSRRGNKSKVI
PPSITKMRKAKDGEELYTGSQNPLGESPIYIFYSSLTGASKRVALQLYDTLNASLGAPLS
LVVKLLSLDDDVEDLDDYFLNVPKLDKPPIYLLVLPSYESDSPIDYFLEMLRETSTDFRV
DKYPLRALAGYAVLGLGDSESWPELFCYQGKLADKWLSKLGGRRVFPFGELCVKSNLQRN
EKRVNLVDKKKMFAFYGINSHRCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWEVDKPDM
ILNGALEGHYKKIKQMRGVPGILIDRFNEAFKVRHCALSLVGEPIFYPYINQFLEMLHDK
EISSFLVCNAQHPDQLSTLGKVTQLYVSIDAPTKEELKVVDRPLFRDYWDRLERCLDILR
TVQSHQRTVFRLTLVKGFNMSDESVGGYADLVERGLPALIEIKGATFCGSSEGNGNPLTM
QNIPFYEECVKFVKRVNEELNNRGLEYGLACEHAHSCCFLIASKKFLVDDKWYTHIDYER
FFELLKSGESFDKMDYISETPEWAYFGSEQGGFNPDDTRWNRKEEKLKKKAERERVAATA
TAIARGETATATTAVDVVVDGPN
>A0A1G4K324|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea dasiensis|TrEMBL
MDLKKDISDHLVLLAVIATYLLSGGRLTIGCSIFVIYALVKHDSVQDEELKASQPLEQES
SLEKKSCCGGKGGSCCSSKLGGKNGGCCGGSCSTKKRLGTGVNDTVPETPSTNDTSVSET
DFTEAFKPLKKVKKAPKVVSGSKLARSKSEPSFFKKALTVSNEKLTDSQIYIFYSSLQGA
AQRSAKAVAKVLSEVEALKHTPMVLNLDDLSDFDDYFVNVPSLNALYVMVLPSYDSDSPL
DFFLQSMDENCNDFRIDKHALRKLTGYAVLGIGDSESWPSKFCYQAKQADLLLAKQGGRR
VFPVGEVCMKFGGDPKVIEWAKLLAETLQDDEPILYEYDESLETEEAEEPLDELTKETLI
DLEDVGKSTELQNVNEIKEMVAKDSPTYKNLTKQGYTIVGSHSGVKICRWTKNDLRGRGS
CYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKTWRWEVDDPEYILENALKGH
YAKIKQLRGVPGVIAERFAKAFEVRHCALSLVGEPIMYPFISKFVSLLHEKNISSFLVCN
AQHPQPLRELGKVTQLYVSIDAPTKTELKKVDRPLYRDFWERLMECLEILKTSQAHQRTV
FRMTLVKGFNMGDVSAYADLVQKGIPCFIEVKGATFCGSSDGNGNPLTMQNIPFYQECVG
FVKNLSAELQRRGLGYDVAAEHAHSNCILIANTKFKVNGEWWTHIDFDKFFELLASGQSF
SHLDYIAKTPEWALFGNGGFAPGNTRFYKKKKPSENKPQADETPVSPQLTQPIAT
>A0A8C2SW61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coturnix japonica|TrEMBL
MAGGLDVSMDTWSFLYTCLVSLWLHRFYIYSVTAFGISLWIAIQFFTTKARRKDENSNGN
LSSSQLVEDKAVNGYAALQTKEVYVAGVKIFYGSQTGTAKRFAEDLAEAVTCFNLPVEVI
SMGDYDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETSNDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNMVGRNIDRWLWMLSARRIMTRAEGDCNVVQSKHGSIEADFDA
WKTKFLSRLQALCRGEKKPCSGKCKKGKCKSQGKQSKESSNNERGAPEFENAEAEELFET
TSEEEADAEEAGGTDSVVDVEDLGKIMNHMKKAKRERELEDGDAGTSLLGETSGRKEAGE
RREMITAALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREALENHRNMIKEFKGVTGVRAERL
EEAMTAKHCALSLVGEPIMYPDINRFLRLLHQRGISSFLVTNAQFPEEIRNLEPVTQLYV
SVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADL
VSLGKPDFIEVKGVTYCGDSSASSLTMANVPWHEEVVRFVQELAQLLPDYGIACEHEHSN
CLLIAHKKFKINGDWYTWIDYERFQELVRAHVDSGGTKTFTATDYTARTPHWALFGSNQR
GFDPLDVRYQRRGKVRDVSGC
>K3WPX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Globisporangium ultimum (strain ATCC 200006 / CBS 805.95 / DAOM BR144)|TrEMBL
MRSTNVGLSPAASAGISVLLVATVALGVIYYAALQRDAHAKPLEFKKSSTTSPKKSKGGR
VKKNGAAANAAVKKAEKQSKRESKKPAPVAVRILYGTQTGTSKTMAETLEKKIFALNIAG
FHFQTSVVSMKDYDQDNLEHESIVIAIMSTWTKGAPPQDARVFCGWINDMALDFRVSKTW
LEKIPHAVFGLGNAEYDEYYGTAAKNLDRELSELGSPVLCPLGLGDDNVDQFDQFEKWSD
NLLAAMCEYNSDQQQQPTDEKPAEKKEWLSQKEFRRQKKAKQEQLEAENGEAIELNEEDY
MNEKVLTGEFSDDDDDDKSTATTKNSDDDVVDVEDIGKSMKESEAANMSREMVTPMQRKA
LLKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFC
WRHHKNPVGRVWRWKTDEAAVLVSGSIERHQNMIKELKGLPGLIQTRWEEAFTVRHCALS
LVGEPIMYPHINEFCRELHKRHISSFLVTNAQFPEKIAALEPITQLYVSVDAATKESLQA
VDRPLFKDFWERFLACLEELKRKGQRTVYRMTLVKSYNMDELDNYAELINIGQPDFIEVK
AVTYCGKSDGSDLTMRNVPWHDEVRDFCAALCERVSGDYGLATEHAHSTCVLLAKKKFCI
EGNWHTWIDYERFHELIAKFYEDGTTFKAEDYMAPTPSWAVYDAPERGFDPIETRFRRTK
DGKVVEFAYEATDSGCG
>A0A673C075|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sphaeramia orbicularis|TrEMBL
MLASWMNLKVYLSFSYFQLSEEVQTLGLTCEVIDMKEYDPDDRLADECTSRSVCVFIVAT
YTDGQPTENAEWFCKWLEEASTDFRYGNTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKW
LWMLSGVRIMTRGEGDCNVVKSRNGSVQADFEAWKVKFLNRLQNLVKGDKKSCSGNCKNG
GSCKNKRKDGHGQEEEEDAVTRQNDGSEEDLMESSSDEDESGLQEGKKSVVDMEDLGDIM
TSVKKAKVRYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWRWKMDPPEKILQDSLEKHENMIRQFRGVPGVKPERYEEGLAVKH
CALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKD
SLKKIDRPLFKDFWPRFQDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDF
IEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTK
FKVDGEWWTWIDYERFQELVQVHEDSGGQQSFSALDYVAKTPRWALFGAEEQGFDPNDTR
FQRRNKTKDISGC
>A0A2R6CT56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QH_10_67_22|TrEMBL
MSESDGPRQVDDPNYHSENHTAAQTCGWTKNALKGEGKCYKNIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPDAVAEASLSLQEKLLSGFGGNEAVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIDAFHERDITTFLVSNGTKPEVLAACDPTQLYVSVDAA
DRQTFDSTVKAVEDDAWERLIETLDVLAAKDETRTVLRTTLVKGHNMHHPGWYATMFHRA
DPDFVELKAYMHVGHSRGRLDRDSMPNHEEVRAFTERVQEHMPDHDVMKEVPVSHVTLLA
RQQDTWVPKLEKDSDFWARDSYAEAGD
>A0A0V0INH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Solanum chacoense|TrEMBL
MPLSLSSYPTRFAILTLLSATTVFFFYKSRRHLSKRLKSLNPISQNPIPKTPRGKIFFIS
QTGTSKTLAKSLHSLLNLNGFEFDLVDPKEYEPEDLHKESFVVIVASTWEDGKPPSNAGF
FVDWLTESADDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVGRDFSKKLKKLGGVEVLEV
CEGDVDEGNLDEVFGKWSKRLLGFXVIWARMERIWGMELVMVVKMKLXVREMNDEEYDDE
FEENDEESGIVDLEDIAGKGPSRKKGVNDKLVNGKSNGGTVNGEKAMVTPVIRASLEKQG
YKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWTWKMDDPIEIVNTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEP
IMYPEINSLVDELHKRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPL
FGDFWERFLDSLRALKEKEQRTVYRLTLVKGWNTEDVDAYSSLFSIGKPDFIEIKGVTYC
GTSATSKLTMENVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKIDGQW
FTWIDYEKFHDLVASGRPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRFKKERHHRSPRQE
NGS
>A0A7N6B777|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anabas testudineus|TrEMBL
LETVVCLLFIKYSGSFCDQERETKDYFMSIWHNRLYLYTAAALFFGIWFALKISLKKVSY
VNSSVNKTEKSSERSDKQKVVHVSGVKIFYGSQTGTAKAFANELSEEVKALGIPAEVTDM
KEYDPDDQLADECTRKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLR
YAVFGLGNSVYFGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSVQADFLAWK
VKFLKRLQALAKGEKKKCSGNCKKGGSCKNKRKDRKVEEEGEKAAQQNNSSEDLMETSSD
EEGSGLEDEKKTGSVVDMEDLGNIMNSVKKAKTDDQIVKLSKLNGVKNIEDEGERREMIT
PALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDPADKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLEV
KHCALSLVGEPIMYPEINAFIRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDAST
KESLRKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAVGQP
DFIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPQYEIACEHEHSNCLLIAH
TKFKVDGEWWTWINYEHFQELVQAYEESGGQQSFSALDYIAKTPSWALFGASEQGFDPAD
TRFQRRNKTKDITGC
>A0A7K7R783|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecile atricapillus|TrEMBL
LDVSMDAWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRIKRKVTEPGTADKLG
NGCATPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVMSLNLPVEVINMGDYDPEDGLA
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQVL
CKGEKKPCSGKCKKGKCKSSGKQSKESSDHEPGTSEHEDTEAEELFESSGEEEAGGTDSV
IDVEDLGNIMGHMKKAKCPASVSGISSHSQASEAWHGQQPVLGDHNISQFCGFRSYKLIG
SHSGVKLCRWTKVCSVSFSHFINTNKARGYKAAEPSRAGDSTLPWAAWQGVTVPCSLRHH
TNPVGTEWRWKMDQPEVILQEAIDKHQNMIRQFKGVSGVEAARLEEALAVKHCALSLVGE
PIMYPHINRLVRLLHQHGISTFLVTNAQFPEEIRKLEPVTQLYVSVDASTKESLRRIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTY
CGESPASSLSMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHCKFQVDGEWR
TWIDYGRFQELVREHERSGGSRSFTAAEYTARTPPWALFGARERGFDPSHVRFQRKNKAG
DTSGC
>M0ZZQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Solanum tuberosum|TrEMBL
MSLSLSSYPTRFAILTLLSATTVFFFYKSRRHLSKRLKSLNPISQNPIPKTPRGKIFFIS
QTGTSKTLAKSLHSLLNLNGFEFDLIDPKEYEPEDLHKESFVVIVASTWEDGKPPSNAGF
FVDWLTESADDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVGRDFSKKLKKLGGVEVLEV
CEGDVDEGNLDEVFGKWSKRIVGLLSNLGENGGDMGNGVGDGSEYEAVSEGDDDEEYDDE
FEENDEESGIVDLEDIAGKGPSRRKGVNDKLVNGKSNGGTVNGEKAMVTPVIRASLEKQG
YKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIDSHRCMEATPSLACANKCVFCWRHHT
NPVGKSWTWKMDDPIEIVNTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEP
IMYPEINSLVDELHKRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPL
FGDFWERFLDSLRALKEKEQRTVYRLTLVKGWNTEDVDAYSSLFSIGKPDFIEIKGVTYC
GTSATSKLTMENVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVDKFKIDGQW
FTWIDYEKFHDLVASGRPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRFKKERHHRSPRQE
NGS
>A0A8H6RBK8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudocercospora fuligena|TrEMBL
MEQSSILQLPEELLLLWHAHRAEVILSAGVLLAVVRLALHWRSRRAKVVLTPLASPVDEQ
RTFPETEHVEKVAVQDEPQVKIQIKAKGPKRVKGVRSVKPKQNEAPAFDRIQPYVFYFSL
GGSTGAHAEKLASDLPRDEKRLPPIVHDLTEIDYDDFFISPPKQESSTTAAFYAILIPSY
NIDTELTNFIDHLQETHHDFRIDTAPLSGLAGYSVFGIGDRIEWPTEELGYCTQAIEIDR
WLAKLTARKRAFPLGQGDAKGDDLGMRLEEWSRGVQNIMQDLSEGKGLGEGAPGSGEALE
SGDEADDDDEGETLVPRKGDAADLEDMKAPIPVDFTTTSKKPGQPAEPKAMVPVTSPTYT
SLTKQGYTIVGTHSGVKTCRWTKSALRGRGSCYKFSFYGIHSHQCMEATPSLSCSNKCVF
CWRHGTNPVGTTWRWQVDEPDLIFDGIKAGHYQKIKQMRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINQLLAMLHAEHISSFLVCNAQHPDQLATLGPVTQLYVSIDASNKETLR
KIDRPLHRDFWERFIRCMDILREKRFTHRTVFRLTLVKGFNVDEEAKGYADLVERALPGF
VEVKGVTYCGTSTAAGAGLSMQNVPFYEEVAAFVVALEKELNSRGLEYGIAAEHAHSCCI
LLADRKRFYKASKTDGTKQWHTIIDYPAFFRCVESGKPFAPEDYVGEATPDWALWGNGGF
DPRDERVDRKGRPKDITTKVGGGKVVEL
>F0NHH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus islandicus (strain REY15A)|TrEMBL
MYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKTLAQY
TGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDIEDDMSGEYKEAEQGCTEGS
T
>H2B185|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 / NRRL Y-8276)|TrEMBL
MEPINPVILSLLGLAASIYVYFGGRISFLAVIAAAYYVIASESSNGKLEQASTVQEEPKQ
KAHACSCSHSGGSSCCKSKSGSNDEKKKKKCCGGKGHHSNKEKTKSNDEFDSLTIDFSDA
FKTKKKSKKDRVKVFNKSKSSMTYVSKYADEENSHGLVKTGLTVSNEALLKSDIYIFYST
LQGNAERSAKIVKENLDIVEELEKEAILVNLDEINDIDEYFVEIPSENAIYILVIPSYDT
DCPLDYFIQTLEENFNDFRLDSFPLRKLVGYTVLGLGDSESWPDKFCYQSNKVDYWLARL
GGRRIFPLGQVCMKYDGNDKIIEWSKLFGEMLKDDEPILYEYDEKVSDANNGEDEEEEDD
TENTSDGETVADVEDLGGKTVNSNSLEIKQMVGKTSPTYKNLTKQGYKIIGSHSGVKICR
WTKNELRGKGSCYKKSLFNIASSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWETDEP
EYILENALEAHYSMIKQMRGVPGVVADRFAKAFKVAHCALSLVGEPIMYPHISKFIELLH
QKDITSFLVCNAQHPESLRTIGKVTQLYVSIDAPTKQELKKVDRPLYKDFWERMMECLDI
LKTVQSHQRTVFRLTLVKGFNMGDISSYASLVERGQPCFIEVKGATFSGSSKDNVNSLTM
QNIPYNEECKQFVESFVKELQRRGLEYDIAAEHAHSNCILIANKKFKINDEWHTHIDFDK
FFQLLKTGEQFTYMDYLSKTPEWALYGNGGFAPGNVREIRKEKKLKNKLKNQTPSVEVVA
>M0JT95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sinaiiensis ATCC 33800|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A7L2T6K2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pomatostomus ruficeps|TrEMBL
LDVLMDTWSYFHTCLVSIWLHRFYIYSAVAFGIGLWIVIQFTTTRTKRKVGEDLLQELGA
DKLGNGCALPQAQEVHVTGVKIFYGSQTGTAKRFARALAEAVTCLNLPVEVINMGDYDPE
DGLSEEASSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYVVFGL
GNSAYADHYNTVGRRIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLTR
LQAFCKGEKKPCSGKCKKGKCKSSGKQSKESLDHEHGTSEHENTEAEELFETSSEEEAEG
TDSVIDVEDLGNIMGHMKKAKVLLLEGGGMVRTDPAAALPSCSPFLSNFLFHFSGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGT
EWRWKMDQPEVILQEALENHRNMIKQFKGVSGVRAARLEEALAVQHCALSLVGEPIMYPQ
INRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFW
QRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSA
SSLTMANVPWHGEVVSFVQELAQLLPDYGIACEHEHSNCLLLAHRKFQVDGEWRTWIDYG
RFQELVREHEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A672RV13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dianchi golden-line fish|TrEMBL
MYKQRLLFDRPQKMLFLALLSCLLYSTVSAAMSGVLNDVWDYTESYLLTVWQNRLYVYTT
AAVLIGVCFTMNMLFKKEKTVDPVSPWLYKSAKKQELSAETEKVIHVSGVKVFYGSQTGT
AKGFAKELAGDVSAQGIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAE
WFSKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMT
RGEGDCNVVKSRHGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGSCKNKKKHKEE
AEDSHSLAEKNNSEEELMESSSDAESSSEEEKSHGSVIDVEDLGNVMNHMKKAKRMEGDE
EDSQRVKLSKQNGVRKSESEEEQREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEA
VENHRNMIRQFRGKDSPERRCLLPSAELFCRLQTNNSGLKGSLVPITQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHNKF
KVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRF
QRRNKTKDISGC
>A0A672RV13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus grahami|TrEMBL
MYKQRLLFDRPQKMLFLALLSCLLYSTVSAAMSGVLNDVWDYTESYLLTVWQNRLYVYTT
AAVLIGVCFTMNMLFKKEKTVDPVSPWLYKSAKKQELSAETEKVIHVSGVKVFYGSQTGT
AKGFAKELAGDVSAQGIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAE
WFSKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMT
RGEGDCNVVKSRHGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGSCKNKKKHKEE
AEDSHSLAEKNNSEEELMESSSDAESSSEEEKSHGSVIDVEDLGNVMNHMKKAKRMEGDE
EDSQRVKLSKQNGVRKSESEEEQREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEA
VENHRNMIRQFRGKDSPERRCLLPSAELFCRLQTNNSGLKGSLVPITQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHNKF
KVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRF
QRRNKTKDISGC
>A0A8C9U6J3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Serinus canaria|TrEMBL
MDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRDKRKGEQSQESPSSPEGTS
DKLGNGCAPRQAQGIHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVDVINMEDYDPE
DGLVEETSSRNICVFLVATYTEGQPPESAVWFCRWLEEAANDFRVGKNFLQGLRYAVFGL
GNSVYVDHYNTVGRRMDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFLTR
LQALRRGEKKPCRGKCKKGKCKSSGKQSKESSDREHGTSEQDNTEAEELFETSSEEEAGS
PDSVIDVEDLGNIMGHMKKAKREQELQEGAAGAERREMITPALRKALTKQGYKLIGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTKWLW
RMDQPEEILQEALEKHRNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHINHL
VRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFL
ESLKALAEKQQRTVYRLTLVKAWNVDELRAYADLISLGKPDFIEVKGVTYCGESSASNLT
MANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYSRFQE
LVRERERSGGSRTFTAAEYMARTPPWALFGAKERGFDPLDVRFQRKNKARDTSGS
>A0A3Q7G9X6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Solanum lycopersicum|TrEMBL
MSLSLSSYPTRFAILTLLSATTVFFFYKSRRHLSKRLKSLKPISHNPISKTPRGKIFFIS
QTGTSKTLAKSLHSLLNLNGFEFDLVDPKEYEPEDLHKESFVVIVASTWEDGKPPPNAGF
FVDWLTESADDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVGRDFSKKLKKLGGVEVLEV
CEGDVDEGSLNEVFGKWSKRIVGILSNLGENGGDMRNGVGGGSEDEAVSEGDDDGEYDDE
FEENDEESGIVDLEDIAGKGPSRKKGVNDKFVNGKSNGGTVNGEKAMVTPVIRASLEKQG
YKIIGTHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGKSWTWKMDDPIEIVNTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEP
IMYPEINSLVDELHRRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPL
FGDFWERFLDSLRALKEKEQRTVYRLTLVKGWNTEDVDAYSSLFSIGKPDFIEIKGVTYC
GTSATSKLTMENVPWHSDVKEFSEALAKKSNGEYEVACEHVHSCCVLLAKVAKFKIDGQW
FTWIDYEKFHDLVASGKPFTSKDYMTPTPSWAVYGAEEGGFDPEQLRFKKERHHRSSRQE
NGS
>A0A2G9NFL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_32_14|TrEMBL
MAMLTDEAKKKLKKQQYIVVGDHSAVKTCGWTKNMIRGKGGCYKLKFYGIMSNQCMQMTT
SMSCANRCTFCWRDYKSPVSKEWKEEWKIDEPEFIYENSVKAHHKLLTGYGGNKNPNPSD
ILYKKSKQIKHVALSLTGEPILYPKMNELLDKFNREGISTFLVTNAQYPQQIRDLKPVTQ
LYISLDAPNPKLLKKVDIPLFRDYWERLNQSLEYLALKKQRTCIRLTLIKGINMNSPDLY
AEMIKKGDPDFIEVKAYMHVGASQERLERSNMPPHEEVKEFAKELLEFLPDYELVSEHEK
SQVVMLAHKKYKFPDENGNSQWHTWIDFDKYNEMVNKGIEPEKMSYMKKTPPGFVIKS
>A0A4V2JUN9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hamiltosporidium magnivora|TrEMBL
MSVNIFYATETNKSLKYAIKLSNALISKNIDVGVHSFDDYFYSEIALFITSTFYDGQVPK
NGRVFFKKLKIAAKNNDLEFKPPKFFAIFGLGSTAYLSLFNLVAKQIYGYLITLNSISML
SPVYSDEYGDMEAVFDNWVSNVCDSLTNNNYQTNQNPKSSEIIDTNNKPDVSDIEDLSLM
LTPSLSKNLKKQGYSLVGTHSAVKLCRWTKSMLKGRGGCYKNTFYGIISSSCMEATPNLA
CANKCVFCWRHYTNPVGTKWRWNADEPDKILKGMLEEQNKLINSVINGVKTEINKFKGVK
HCALSLVGEPVMYVHIYKLIELFHKEKISTFLVTNGQFPDQMRALKDVTQLYLSIDAGDP
VSLREIGRPLFTDYWERLLECIDILKEKRGRTVFRLTLVKGINDETTDSNKEEQERNENI
LGGYISLIKRGTPDFVEIKGVTFCGWTQDSGLSMKNVPYHNDVINFAIQLINGLEGYEIA
CEHEHSCCILIANTKYKKNQKWYTWINFDKFNEDLQGIEYSCETPDWALFGSREKGFNPN
ETRYQRKKNQIK
>A0A368SE77|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Setaria italica|TrEMBL
MTVARGPPGRPSSALLGCWRRRQPLGFGAKVGIAIALGLSFAIIWTSVSPTSSSQQISTE
RSSFAAEVAAPPTASHNRTSTSIAGGHAHRKPRPVPHSHKKRHPAPSGSHSHPHRTNATS
SPDAAAAKADHSEPAPITDPEPKEKEPEQEQEQEPDMEMEPEKEAELPMPEESGDNSGKA
PAEGEEEKPPQLELEEEPGEGDGDEDFEVAKKAAPSKKRKLPPLFSSSAHYHWKHCGAKS
GYHYIPCVDFDGDGSQRHHERSCPRSPVTCLVSLPKDYKQPAPWPERKDKVWYANVAHPR
LSNYVKGHNWLNHSGEYLMFPLDEWEFKGGARHYVESIDEMAPDIDWGKNIRIVLDIKCK
SAGFGIALLEKDVITLSLGLTNDQTDLAQVALERGIPATVGSLGSQRLPFPSGAFDAIHC
GECNIPWHSNGGKLLLEINRILRPGGYFIISSKSADLESEEGISASMTALCWNAIAYNSD
DVSEVGVKIFQRPATNEEYDLRAKKDPPFCKEEQNKANAWYTHIKHCLHKAPVGIEERGS
DWPQEWPKRLDSYPEWLGDLQTRVAADHNHWKAVVEKSYLDGLGIDWSNIRNVMDMRAVY
GGFAAALASKKVWVMNVVPVHASDTLPIIYERGLIGVYHDWCEPFSTYPRSYDLLHADHL
FSRLKIRCRQPVAIVVEMDRILRPGAWAIIRDKLEILDPLETILKSLHWEIVMTFRKDKE
GIMSTLATRLSDRLTANAGVPILATDASSFEPDDLPSVPLLLLVVPTHDGGAPPPSAAFL
ARWLEESTADFRAGALLLSGLRFAVFGVGSRVYGETFNAASRNFSRWLRALGAVEVVPLG
EGDVDGGELEAVFEDWSGKVLRVVKGEELNEGVLGESDGLDELELEGEESDDDDEEETVA
VEIDMEDIAGKAPARQNGKVEGSLANGGQNGVKEMVTPIIRTSLEKQGYKILGSHSGVKI
CRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMD
NPLDIANAAIDQHTKMIKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVDE
LHRRHISTFLVTNAQFPEKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSL
KSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLTMEN
VPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHEL
VTSGKPFKSQDYMALTPSWAVYGAEEGGFDPDQSRFKKERRHGTAALKG
>A0A7L0WP79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alectura lathami|TrEMBL
DASMDAWSLLYTCLVSLWLHRFYIYSVTAFGITLWIAVHFFVTKTQRKGEECNGNLAASG
AEDKLVNGYAALQAKEVHVAGVKIFYGSQTGTAKRFAQGLAEAVISLNLPVEVISMGDYD
PDDCLVEETASRSICVFLVATHTDGQPADSAAWFCRWLEEAASDFRFGRTYLRGLRYAVF
GLGNSVYVDHYNTVGRNVDRWLWMLSASRIMTRAEGDCNVVQSEHGSIEADFEAWKTKFL
TCLLALCRGEKPCSGKCKKGKCKSQGKQSKESSNHEHGTPEYKNTEAEELFETSSEEEAG
AGEAGGTNSVIDVEDLGSVVSHMKKAKRERELEEGGVGTSSCGETAGRKEAGERREMITA
ALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHRNMIKQFKG
>A0A7K5J110|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxostoma redivivum|TrEMBL
DVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKAEKSRGNPSSPK
GTADKLGNGCVPPQALEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDY
DPEDGLVEETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAV
FGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKF
LTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEDRPSEHENTEAEELFETSSEEE
AGGTDSVIDVEDLGNIMGHMKKAKVLLIQGEWNGAAGAGRKEEAERREMITPALREALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVQAARLEEALAVKHCALSLVG
EPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDR
PLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELISIGKPDFIEVKGVT
YCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLLAHCKFQVDGEW
RTWIDYGRFQELVREHELSGGSRTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKA
RDISGC
>A0A7K6T5M4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caloenas nicobarica|TrEMBL
LDVSMDTWNFFYTSLVSLWLHRFYVYSVVAVGISVWIIIQFFTTETKKKVSEDGTSSEGI
EDKLVNGSATLKAKELYVAGVKIFYGSQTGTAKRFAQGLAEAVISLRLPVEVISMGDYDP
DDCLAEEATSRNVCVFLVATYTDGQPTESAAWFCKWLEEAAHDFRFGKTYLKGLRYAVFG
LGNSVYVDHYNTVGRNVDRWLWMLSASRIMTRVEGDCNVAQSKHGSIEADFEAWKAKFLS
RLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDPEHGTSEYENTEAEELFETSSEEEAD
AEEAGGTNSVIDVEDLGNIMSHMKKAKRDRELEDGDVGKNLTQEKAGRKEESERREMITP
ALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEIILQEALENHRNMIKQFKGVLGVRADRLAEAMTAK
HCALSLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTK
ESLKRIDRPLFRDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPD
FIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQDLAELVPDYEIACEHQHSNCLLIAHK
KFKVDGDWFTWIDYGRFQELVREHERSGGAETFTAADYVARTPDWALFGSRERGFDPLDV
RYQRKNKARDISGC
>A0A8D1QY08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKSLS
VSADVPLMGSQIFLRTSPWTPRCGCPSNPEQGSLRMRKRGAEEPLEGERSRRGAGPPTSP
LGKSSPPNPSRRNKLSRMFTRDLIVFSPQVGGGVGAGSLCAKCLGGGGRERRPPGPDDRG
GVPRGCTSHWDRDLAICLEL
>A0A497LF48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MELETHYLYKKFRNSSLVKSQRPVDVNEMENAGSSLEFREILYRQGYRIVGNHCHSAVKI
CQWTKESLRNNRVCYKELWYPPVESHRCMMMTPYLGCNLHCLHCWRLHSGDRLGLVWKEF
PLEIEDLDEPAQIIDEAIKQRKLLLSGWKGNPRVDKKKFEEALNPSMMTMSLTGEPTLYP
MISEMVDEARKRGMITFLVTNGTIPEALERMENLPFQLYISILATSKKDYIRLARPLIRD
AWERLNETIDLLPSLDTRRVLRLTMMKGYNMMDHEGYAEIIERAQPDFVEVKAYEWVGES
QRRLPRSAMPYMNDIEEFAEKLSTLTGYTIKGRFKPSGVVLLVG
>A0A7C3XFM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MGGKIPEEFLSVLKRQKYHLVGSHSAVKKCRWLHESLVRGRHCYKEEFYGINSHRCLQLT
PSVAYCNQACLWCWRVMARDIGIEFDESTVPSPESASSIVEGCIFEQKRILSGYKAQVKS
GIVPARKYEEACDPKHAAISLAGEPTLYPFLGELFLEFRRRGFTTFLVTNGTNPRALEKI
VEPTQLYITVGAPSEEVYRRACRPSRPSLWDGIMESLEMVRSFSCPTVVRLTLAKGMNMV
DPEGYAKLVLRAEPTYVECKAMMSVGYGLMSGRMGQENMPSFQEVRRFSEDISKLTGMNI
IGERSDSRVVLLSRLERPIKLRPE
>A0A7J2YTW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MEQTAASPLLAALKKQKYHLIGAHSAVKRCKWLYESIVNNRPCYKQKFYGIQSHRCIQMT
PSLYYCTQQCLFCWRAQSGDMQVRWDEMRNPNKDTPEQIVEGCFRAQEKIISGYKGNEKT
DWRKFQEAQRPKQVAISLTGEPTLYEPLGELIRLFHQRGLTTFLVTNGTLPSKLSKLSQE
PTQLYVSLCAPNEEVYRRVCRPQFPAAWAKLNETLELLKSFRCPTAIRMTMVKDHNMDQI
DGYAKLVEKAQPTYIEAKAYMHIGFSNLRLGFDRMPMHDEVKKFAAQLAEKTGYRVINEA
PESRVVLLSKLEKPIQLGSG
>A0A842SM65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLPPDFQESYRKQKYGLVGAHSAVKTCHWQRRSLNTRGEEVCYKQKFYGIPTHRCLQMT
PSLGHCTQSCVFCWRATPETLGISWEQTQLLGDPENPEDIIEGCLEEHRRALSGFGGNPN
VSEKMLEEAMDPLHAAISLEGEPTLYPLLGDLVDSFFSRGFKSVFIVTNGTNPEILENLG
TEPSQLYVSLCAPDKETYEETCRPMILGGWERVMKTLDLLESFSCPTVLRHTLIPGLNMI
RPEKYVKLAERASATYMEPKAAMSVGAARDRFGYEEMAWFKDIKEFAVRMAEAGSYNIID
EHRWSNIVLLSRLESPIQLY
>A0A3R7FBH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MRKAKVKTLENTIPQSLIETMKKQKYHFVGKHSSVKRCRWLYETLIHNRPCYKQKFYGIK
THQCIQMTPATFYCTQRCLFCWRAQSGDLQIKWNEMKFPKWDPPEEIVEGSIKAQLAILS
GYKGNPKTNQQKLREALTPKHAAISLTGEPTLYEHIGELIQAFHRRGFTTFLVSNGTMPE
VLAKLSEEPTQLYISVCAPNESTYKRVCRPQIPKAWERLNETLSLLPSFKCPTVIRITLV
RGLNMENVEEYAKLIEKANPTYVEPKAYMHVGFSRLRLSYDNMPSYTEIREFAAKLSEEI
DYNIINESEDSRVVLLSKLEKAIKFGNS
>A0A842XT86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MFRKASITWESDVLETLVPSSLIQALKKQKYHLVGKHSAVKRCRWLYETLIHDRPCYKQK
FYGIKTHQCIQMTPALFYCTQQCLFCWRAQSGDLGITWNEMKMPKWDSPEEIVEGSIKAQ
LKILSGYKGNPKTNQKKLKEALKPKHAAISLTGEPTLYKPIGELIQAFHRRGFTTFLVSN
GTVPSALANLSEEPTQLYISVCAPNKETYKQVCRPQIPKAWEKLNETLELLPSFKCPTVI
RITSVRNLNMKNAEAYAKLVEKANSTYVEPKAYVHVGFSRLRLNYENMPSHKEIRDFATR
LGKETGYNMIDESKESRVVLLSRLEKPIKFADN
>A0A2T8I0F6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panicum hallii|TrEMBL
MPPSPTATTASATSHLALLFLLSSSSLFFFYKSIRLRRKPSPATATATGPARTTIPTLLY
ASATGTSKTLAARLSARLTADVGVPVNATDATSFDPDDLPSVPLLLLLVPTHDGGAPPPS
AAFLARWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVEV
VPLGEGDVDGGDLEAVFEEWSGTVLRVVKGEELNEGVEGESDGLDELELEGEESDVDDEE
EAVSGEIDMEDIAGKAPTRMQNGKVEGGLTNGGQNGVKEMVTPIIRTSLEKQGYKILGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
KWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEIN
ALVDELHRRHISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAVDRPLFSDFWER
FLDSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGLQLQS
>A0A2V1DZA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Periconia macrospinosa|TrEMBL
MPLTELLDQLPAELLLIWHTHRVPILLSAVSFAALIHLTIYLRTKRTKISVSPAPSSPIE
KIEIKLRPEWLPENTTLVAPELNLDNHAEDSNVVPEAPIAKVKKGPKTVKGKRKTSKKSP
APAPSFDHKVDKIQPIVFFQSLAGTTERYAAAFEKVLTEWTLGCDQASSFLEPQLQDLSY
IEYDDYFITPPKTEDNIKHFYIILIPSYNIDTVLSTFLENLQETHNDFRIDTSPLNGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKSDAEERLVEWRV
GVQEALVEIAEGRGLGEGVPGSGDPAESDEEDIEAAEDSDSEGSNPSNNRVKKTARVDEI
EDLGSMVDPSSTSSPIPIDFTSYKSTTKPSKAAPAPKEMVPTTSPTHAALTKQGYTIIGS
HSGVKICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTT
WRWVTDAPDLIFDGITAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHI
NELLSIMHKNRISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFCACLDILRHRRFEQRTVFRLTLVKGFNMADEVRGYADLVERALPGFVEVKGVTYCGTS
AAGSAGLTMQNVPFYEEVAAFVTALAEELRNRGLTYGIAAEHAHSCCVLLADSTRFQRDG
KWATRIDFERFYDLYERKVQGTRVDEKGEVVGWRPEDYVGMETPEWALWGNGGFDPRDQR
VWRKGKGKKDGEKEKEKDEGEVKGGNVRLVEI
>A0A395SNV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium longipes|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAVRIYFQFNGQKTEVVAFKKA
YQEPAKPKVVVEEVKVEEVKIEEKTPTKEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDVTRPVVPLVFFCSVTTKTAKIAQAYVEQLGGRLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKVHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWAKGVEE
VIEHVARTGSLGEGLPGSGAAEESDVEDIAEDEDDGEVIIEDDATNKKTKGGRDLDDVED
LGRMIRKDDGSTTQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPELIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
ATSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFNVDG
KWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A650CNB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stygiolobus azoricus|TrEMBL
MESKSTFRIDTLSVIMKELEKEKYHIVGSHSVYKKCHWTHEALTSGRYCYKGKFYGIESH
RCVQMSPSAAWCWFRCIHCWRLEPEDIGVEWDETKIPIEDDPEIIAEKSIEEHMRAVSGY
FGREGVPKEKAKEATMPKHVAISLTGEPTLYNRLGELISEYHKRGMTTFLVTSGVRPDVL
ASLEEEPTQLFVSLQAPNEKKHKIINRPIVANSWNLVMKTLKILPSFSSPTVIRMTMIKG
FNMSEEDAREFAKLIELSQPTYIEVKAYMHVGPSTYRLTKDAMPRHSEVREFAKILSNYT
GYKILSEHVPSRIVLLSKLDRPIQIGNAWSEKWNWSTKDVEDDISGEYKEAEQDCSEGVS
>A0A1V4UJQ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon PtaB.Bin108|TrEMBL
MCYKHQFYGIDSHRCVQMTPTLRCNQRCLFCWRSFEHEYPGERDLSPAEIVGSVRKYQKK
ALSGYKPSPYVTQERFSEALDPKHVAISLSGEPTLYPYLPELIDLFSSEGFTSFLVSNGT
RPGVLAKCRPFQTYISLTAPDRETYMKVCRPLEDTWDAIQESLSLMGSRRSAVRITLVKG
YNDHEPGSYARMIQESGTSFAEVKGYMFLGYSRNRLERGNMPSFAHVKGFAEKVAAECEY
RVRDENPLSRVVLLERVE
>A0A7K6JTB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreocharis arfaki|TrEMBL
LDLSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPASSEG
TADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVASLNLPVEVINMGDYD
PEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCGGKCKKGKCKSPGKQSKESSDHEHGTSEHENTEAEELFESSSEEEA
EGTDSVIDVEDLGNIMGHMKKAKAKLNCLMIFALFSGYKLIGSHSGVKLCRWTKSMLRGR
GGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIE
NHRNMIKQFKG
>A0A5B6VD95|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium australe|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRRLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPQTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGSLLLSDCKFAVFGVGSRIYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFVGWSEKVVTVLKGGLVMENGNGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGEFTRPIVAGVTQERLMEGLSPRHCALSLVGEPIMYPKINALVD
ELHRRRISTFLVTNAQFPEKIKMLKPLTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDS
LKALKEKHQRTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTME
NVPWHSDVRAFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHD
LVASGRPFDSEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A3R7NBL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma conorhini|TrEMBL
MFQPLAEALMALPPELLLWTLLGALLPVVIMTIGTLLDRWRLRRKPQQTQAEATEGDATG
SGREAQGDGCCTRRQAPANGGAGKKILIAYATQSNTACKLAHKLFSTLNAALHEAAGEVA
QRGSACCGAASYVPEVRVLRLAEEARQCSVEHLLESHAYSFVVLIASTYTNGTAPASSQM
FADLLQDAYTDFRVPRDTLARTRFAVFGLGDVAYGANHFNRFAKNLYTWCKGLGATFVTP
PVYASEANTVPLFNVFTASVVKWVGRVVFTADGVVVVRKPRRAETTRPPAVANAAPDSED
DDDDDDAAAAEGESEACGDDVEDAVTDDDDDGAAAAAAAAGDPPELLHPRLRQNLQRQGY
HLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIASHQCMEMTPSLACANKCVFCWRHHTN
PVSRTFRWKVDPPQQLVAGGIAGHQQMMKQMRGVPGVTAARLEEGMQVRHCALSLVGEPI
MYPEINAFVDLLHERGISSFMVTNAQFPEQLRLLKPVTQLYLSIDAPTPEELKRVDRPLF
EDYWERCLACVRELRRKPQRTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCG
TSSTSTLTMKENVPRHEEVVRFCADLCAALAADTAPKDKRTWLAQAPAEAELHGSASQRS
DNETGNNVSNGNPAQEGVAAASSGPYSIACEHEHSCCVLIALRRFLVQGVWHTWIDYDKF
TALAGSGRTDFTAAEYAAPTPSWAVFRSDEKGFDPTQVRVHRKSGKPAVVTSGC
>A0A0E3P9J0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina siciliae T4/M|TrEMBL
MPLEERKEEKKDSGESFPEIPEENRGEEQASLPFDIPDFATLLKKQSYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLICNHRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIDCQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDIMK
EKCSRTVIRTTLVKGENIFSPEGYAELIKKASPDFVEIKAYMHLGFSRLRLDRSAMPAHA
EVLEFSKELAKHLGYDIADESEISRVVLLSKDGKKSPVRKVSFKD
>A0A534JMC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDVQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGIGCYKQTFYGIESHRCLQMTPTVD
ACNLACQFCWRTQEWGSDSLPLADDPGLIVEESIRAQRELLSGFKGNPNVPREKFLEAWH
PTNVAISLTGEPTLYRRLGEMIDEFKRRNMSTFLVTNGTTPAALRRMHSEGRLPTQLYVT
VAAPNEEIYRRLMVPKSGNEWRKLKETLALLPSLPTRTVIRHTLVEGWNLGWEDEYAELD
RIGKPMFIECKGYSFVGESRLRLEAGNVPSHSSIHAFAEHLANRIGYEIAAEREDSRVVL
LTADGELHPLSR
>A0A2E8JUY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVESHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKQVFDEVCRPKYNHGAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDEHIAQFAALDN
RADPDFIENKGYVFVGHSRENLSMENMPSHDDIMDFSNKIAPLTDRKVLSDSRPSRVALV
GRNITPIPIPEPTMFFPEDLGIAPSVKHLPIAS
>A0A2E1MDH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFYKLEETLELLPSLDTRTVCRHTLIKHESMGHHDDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEVLEFSQKLAPMVGREVLSDRRESRVALIGK
EMIPVELPVANTELPKDLGIAKPQRFLLPQA
>A0A831JX20|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MPVLPHVREMLRKQHYYLVGEHGAVKLCHWLKKKLTEGRACYKENFYGINSHRCLQMTPA
VDICNHACIYCWRYQAPQEWPLNVRSSGGWDDPRELVEGLIEGQRALLTGYKGNPKTNLR
LWEEAQNPNQAAISLSGEPTLYPHLSELIEEFHRRGFTTFLVTNGTMPEVLERLDPLPTQ
LYISVDAPNERIYKSLCRPYIRDGWERIKKTLELLPSLDTRKVVRHTLVEGWNLGYVKDY
ARLDKVASPEFVEAKAYMFVGYSRQRMRIDNMPSFERIKSFAEELSRELSYTYHAEQPPS
RVSLLISDPKRIKVRLDN
>A0A816QVI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica napus|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLNPSTRRGKIFFISETGTSKSL
AQRLHKLLESNGIAFDLVDPTSYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSGCRFGVFGVGSRAYGEEYNAVAKEMSRRMVGLGGAEMVPLGEGDVDDG
ELDRAFQGWCDGVIRVLKGGSAQAQETNEITQNGVVESEDEYIDTTDEEEEDDNNDIVDL
EDIAGKAPSRKNGVVKVTKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVNG
ALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIST
FLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQQ
RTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALSVKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFT
SRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>A0A7C5FC28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MPIQDAYRKILAKQQYRIVGRHSGVKLCHWMRQKLIFGRACYKEDFYGIQCHRCLQMTPT
INQCTLKCLFCWRHQGFSETLLEECDDPREILDKAIEAQRKLISGFKGDERCNLELWKEA
QNPNQVAISLSGEPTLYSGLGDFIAECKRRGFTTFLVTNGTKPEVLEKLNPLPTQLYVTV
AAPNEDIFKKLCVPMVDGAWNNLKKTLELLPSLKYRTRTVIRHTLVENWNVANVEEYAKL
DAIAKPDFIEPKGYVFVGYSRMRMSINNMPSQERIREFSKKLAELVGYEYVREKADSRVT
LLSSKGPAVRLNLNTL
>A0A2E6G179|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPNANREKFLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCRPKFDQGAFHKLEETLRLLPSLDTRTVCRHTLIKHESMGHHEDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSXENMPTHQEILEFSEKLAPMVGREVLSDRRESRVALIGK
EMIPIELPPPKKELPKDLGIAKPQRFLLPQA
>A0A1B8X074|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp. DAL1|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVRGEGECYKARFYGIDSHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A7K7T3Z0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapayoa aenigma|TrEMBL
LDPSMDTWNYFHTCLASIWLHRFYIYSAVAFGISLWIVLQFSTTKAKGKGGKSNGNPASS
KGTEGKVVNGCAPPEAKQVCVAGVKIFYGSQTGTAKRFAKALAEAVTSLHLPVEVINMGD
CDPDDCLVEETRSRNICVFLVATYTDGQPPEGAAWFCKWLEEAANDFRFGKTYLKGLRYL
VFGLGNSEYVDHYNTVGRRVDRWLWTLGASRVLSRAEGDCNVARSRHGSVEADFEAWKTK
FLSRLQALCRGEKKPCGGKCKKGKCKSPGKQSKESSDHEHGPSDHDDTEAEELFETSSEE
EADAEEAGGTNSLIDVEDLGNIMGHMKKAKGRRELEEGDVGMRENSGRKEEGEKREMITP
ALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEKILQEALENHQNMIKQFRGVSGVKAARFEEALTAK
HCALSLVGEPIMYPQINSFVRLLHQHNISTFLVTNAQFPDEIRSLEPVTQLYVSVDASTR
ESLRRIDRPLFKDFWQRFLDSLKALAEKRQRTVYRLTLVKAWNVDELQAYADLISLGKPD
FIEVKGVTYCGESSASSLTMANVPWHQEVLGFVQELTDLLPDYEIACEHEHSNCLLIAHT
KFRVDGQWFTWIDYGRFQELVREHERSGGSRTFSAADYMARTPPWALFGAREQGFDPLDV
RHQRKNKARDISGC
>A0A834BCJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MGPSLDSWDFSPLISLWINRFYVYLGFAFAISLWICFQIAIRKQDKNSQKKSVPKATRDL
MTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPVAIINLKDYDPDDN
LVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEASSDFRFGKTYLKGMKYAVFGLGN
SVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEADFRAWKTKFVFQLQ
VLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEEEEPCESSSGEESGT
EDHQSLTSIVDVEDLGKIMSHVKKEKREKEQQEEKTGLFRNTVKKEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGVKEERFKEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPVEIRNLTPVTQLYVSVDASTRDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVRELVALIPDYEIACEHEHSNCLLIAHKKFKI
EREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMAKTPPWALFGANERGFDPKDRRYQR
KNKSKDISGC
>A0A3Q2YFM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hippocampus comes|TrEMBL
MRQLYTILSIVICFLSPGLHSSHSASENYAMYIWHNRFYVYAAFALALTLWVSFKMILKK
VHWQKKDSALLKLNINTIKKGCYNGDTGFTPTTLQGFAKQLSADVRSLDLATEVIDMKDY
DPDDQLADECSSKCVSVFLVSTYTDGQPTDNAEWFCKWLEEASTDFRYGRTYLKGLRYAV
FGLGNSLYAAHYNTVGKNVDKWLWMLSASRILTRGEGDCNVAKSIHGSIQADFLAWKVKF
LKRLRDLCQDDDNCCRKRKEGTSCIQTDGQEVEEGKNTALDNNNSEIPSDGGQVAKRSRK
VARKNQEGKEERREMITPALREALSRQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIQSHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILEEALEKHQNMIRQF
RGVPGVKSDRYEEGLTAQHCALSLVGEPIMYPEINRFVRLLHSRRISSFLVTNAQFPEEI
RTLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWTRFLDSLKALAEKRQRTVYRLTLVKAW
NVEEITAYSELVALGQPDFIEVKGVTYCGESSASSLTMANIPWHQEVVVFVQQLVNMLTD
YEIACEHEHSNCLLIAHKKFKVNGKWHTWIDYDRFQDLARAYQESGGEKVFSSSDYTAQT
PDWALFGASEQGFDPAETRFQRRNKGKDLSGC
>A0A087RSA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote SCGC RSA3|TrEMBL
MSCSGEVVEGEEQLIQIKPAISEQLKKAKYGVSNHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFVKINKPKYDDSWERWNRTLGMLKHLDTRTVL
RITLIRGYNDQTDMIPAFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMQEVKRFS
EQVAKQSQIFSVMDESFVSRISILQNNERFIDRWIPAYANTN
>A0A8J8PQ23|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. B5|TrEMBL
MLAMQSNIRIDTLSEIYKELKKEKYHIVGTHSAYKKCHWTHESLVTNRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDDTKMPAYDDPEYIVERSIEEHKRAVSG
YFGREGVKLEKVKDAMKPAHVAISLTGEPTLYEKLGELIREYHKRGLTTFLVTSGIRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLLMKTLEILPSFSSPTVIRLTMIK
GYNMSDEDAKEFAKLFQIAMPTYIEVKAYMHVGPSTYRLSKDAMPRHNEIREFAKLLSNY
TGYKILSEHVPSRIVLLSKLDEPIKIGNAWNERWDWRTVDIEDDINGEYKEAELGCTEGS
T
>A0A443N1H2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cinnamomum micranthum f. kanehirae|TrEMBL
MTEKPSSSLLPARFALLALLSATAFCFWKSRRLRHLKLLSSSQNPRNQTTQNPKPKPKLF
FASQTGTSKTLALRLSGLLSSHNLPFDLLDPNDYEPEDLPNETLIILVASTWEDGRSPPN
AGFLARWLAESADDFRVGSLILSCCSFAVFGVGSRSYGASFNAFAKEFSWRMRALGAREM
LPLCEGDVDGGDLDGVFDLWSKRLLAALEGKEGNSPGSVLENGGVSESESFGGSEDDESD
ADEESGVVDLEDIAGKGPSRNSANKGLNSKSVVKPLASMNGEEKGVKEMVTPIIRTNLEK
QGYKIIGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGKSWQWKMDNPLEIVNAAIDQHTKMIKQMKGVPGVKPKRLSEGLAPRHCALSLVG
EPIMYPEINTLVDELHRRRISTFLVTNAQFPERIRMLRPITQLYVSVDAASKDSLKAIDR
PLFADFWERFIDSLTSLHEKQQRTVYRLTLVKGWNAEDIDAYTNLLRIGKPDLIEIKGVT
YCGSSATSKLTMENVPWHSDVKAFSEAMALKCNGEYEIACEHAHSCCVLLARVDKFKVNG
QWFTWIDYEKFHDLVASGQPFSSEDYMAATPSWAIYGAEEGGFDPNESRYRKERRHGADA
LRN
>A0A2P4ZDN9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma gamsii|TrEMBL
MDAGIRLQLGTAVADLVELWHAYRTSIILCALVLLVGLRTLLHAAEDREPLAVLPKIYNQ
EKPEANEKTAREAPPVAVAEKKSTGPRRIKGGVTRKPSHEKKATAVDTDRPTKVLVFFSS
ITTKTEKIAHEYIKTLETFLDQKAGETESKFLKPELLDLTEIDFEDYFVSPPKSAENAAY
VYLFLLPSYNIDSINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEGF
CFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHTERFTEWTTGVQDVISQAVQTGFLGEGV
PGSGDAVESDEEDAEADDGEVVFDDEESGDGKSSDDSRPLDDVEDLGKMIRPNKDGNGTT
RKAPLAVDFTTYPSATKKKAQAPIIKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEAEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLQEKGLDYGIAAEHAHSCCVLLASKRFNVNGKWHTHIDYQRFF
ELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVTREAPE
>A0A366RLD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium coffeatum|TrEMBL
MDWTNQSSHSRLDSLVDDLVDVWHIHRVPILLTTCVILVAVRLYFQFNGQKTEVIAFKKA
YEEPAKKAYEEPLKPKIVVEEVNPEVKIEEKTAIIEPAEEKKNAKSQGPRRIKGGVARKP
SKKTEEEKDVTRPVVPLVFFSSITTKTAKIAEAYVEELGGKLDEISKKSGRQFLKPETRD
LTEIDFDDYFLTPYKAHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSS
LMGYSVFGFGDKENWPTEADGFCFQAKEVDRWMAKLTARKRAYPVGMGDMQSDHEQRLQE
WAKGVEEVIEHAARTGNLGEGLPGSGAAEESDVEDISEDEDDGEVIIEDDATGNKTKGGR
DLDDVEDLGRMIRKDDGSTTQKAPLAVDFTNYGSSTKKSVPQGPKKMVAEESPTYKALTK
QGYAIVGSHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRH
GTNPVGTTWRWVVDPPELIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVG
EPIFYPYINEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRKIDR
PLHRDFWERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVK
GVTYCGTSTSSNAGLSMSNVPFYWEVCDFVKALNKRLEEKGLKYGIAAEHAHSCCILLAS
ERFNVDGKWHTLIDYKKFFELLEERGPGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDR
KGRKIEAS
>A0A0P6JHT2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Heterocephalus glaber|TrEMBL
MDPSLDVWDLSSPLLSLWINRFYIYLGFAFGLSLWICFQIVIKKQTKNSQEKSIPEATQD
LMTNGYISLQKKEIFVSGVKIFYGSQTGTAKGFAAILAKAVTSLDLPVEVINLKEYDPDD
RLTEEVTSQNVCAFLVATYTDGCPTESAEWFCRWLEDAARDFRFGKTYLKGMRYAVFGLG
NSAYPSHFNKVGKSVDKWLWMLGANRVLARGEGDCDVVRSKHGSIEADFMAWKARFISRL
QMLRKGENKSCGGRCKKGKCEPKPRGSEEAEPGSHPPPGSHPRDAKEEEPCESSSEEGSG
PDEHLSLNSVVDVEDLGEIMNHMKKEKREKDRQEENTSLFGNTGKSDGSEGRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAMENHQNMIKQFKGVPGVKLERFEEGMKVKHCA
LSLVGEPIMYPEINRFLKLLHHCKISSFLVTNAQFPVEIINLKPVTQLYVSVDASTKDSL
KKIDRPLFKNFWQRFLDSLTALAAKPQRTVYRLTLVKSWNVDELQAYAELVSLGCPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVWELVDLIPDYEVACEHEHSNCLLIAHRKFK
IGGEWWTWIDYNRFQELIQEYEDSGGARTFCAEDYMARTPHWALFGASERGFDPKDTRHQ
RKSGSKNIARC
>A0A098VSA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mitosporidium daphniae|TrEMBL
MIFSFLLLSLKVVSVLVLCYLIVSRKNKRSILPPERKPKVIASSSVGVKIFFASNSGHSE
KYAILMHESLCRFFAKHPSAKRKFALCGPKSLEYYDPDDLYTEDSVLFLFVPTYTDGQPP
LAAKWFSAFLEDAANDFRVDRSSLKRLKFGVFGLGDSAFAPEHFNTAGRCIDKNLSLLGA
TRIISFGNGDQQIDRLSVLGDWINRAQLLLSCYSENPEWISIPMEDFSQALPYESDEDIS
SEPVIDMEDLEILDSQEKTMQEDSNGRYFSGVAIQSKRKSRLANVVPALEEEDDPSFSKF
ILEPSPSEVPMVTPEIGRSLTKQRYKVVVSHSGVKLCRWTKAMLRGRGGCYKHTFYGIES
HRCMEATPSLACANKCVFCWRHHTNPVGTRWVWKLDSAESIVSGALAGHASMVKQMMGVP
GASPERLLEAQVVKHCALSLVGEPIIYPHINELVALLHEKSISTFLVTNAQFPDRIAQLS
PITQLYVSVDASTKASLKKIDRPLFSDFWERFLCSLKALKEKKQRTVYRLTLVNDYNTEN
LKEYANLVNVGVPDFIEIKGVTFSGAGSTATTTGADTSASLRMSNCPFHHEVVSFCQQLC
ALLGGMYSIASEHAHSNCVLIAHEKFFIDGKWFTWIDYEKFQQLIRLGQPFTSLDYAKET
PQWAMFGSEHRGFDPCETRHYRNKQPKEAAVEVTKTGSPDVCCSTQSSSKDTENLPNYNL
ATCSSGDCCMGQRPESEPAMCGDAESRP
>A0A6J1UAU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Notechis scutatus|TrEMBL
MDTPADTWDNIHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKTRLAELNLSK
ITAAKKEQQDPSFEKVHVAGVKVFYGSQTGTAKRFALVLTEAVASINLPAEIIDLQDYDP
DDSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDSNVVKSQHGSIEADFEAWKAKLLM
RLQALAKGEQKACSGRCKKEQCRSKSKVSQEAKEQETSEHAEKEEEDFFETTSEEESDTE
NGRGADQVVDVEDLGKVMDQMKKSQKEHQTNGEVPIGVGTQHGRGEDERREMITPALRDA
LTKQVNASWERRLLQAHLLWHESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQ
PEMILKEAIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALSLVGEPIMYPQINQFLKLL
HHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLQ
ALAEKRQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEIKGVTYCGESSASNLTMANV
PWHEEVTHFVQDLADLLPDYEIASEHEHSNCLLIAHKKFKIEGKWHTWIDYDRFQELVHE
YEQSGGIKTFTSADYVALTPPWAIFGAKERGFDPVDTRFQRKNKIKDISGC
>A0A3R7V2B1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED248|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKVLENLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNSRAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDKHIEQFAALDN
RAEPDFIENKGYVFVGHSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GHEITPIPIPEPTMFFPDDLGIAPSVKHLPIIQ
>A0A2H9MMS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon CG01_land_8_20_14_3_00_38_12|TrEMBL
MNPNLRKILEKQHYKIVGSHSGVKACHWLKEKLIHNRCCYKEKFYGIKSHRCLQLTPTIN
QCTQNCLYCWRYQDFTEQELESFDEPEFVLEKSIDAQRLLISGFKGDERCDKKMFEEASN
PNQVAISLSGEPTIYPKLAEFIEVCHKKNMTTFVVSNGTQPEMIENLKPTQMYITVAAPN
KEIYKKLCAPMIKNSWEKINESLDILSSLNTRTVVRHTLVDKWNIGLENSGEGSSPSRQI
SSKFVDEYAELDMKAEPDFIECKAYMFVGYSRQRMNLENMPSHEKIKGFAEKLSDLTGYE
VAGEKKDSRVVVLAKDKRKMKI
>A0A7J6JDR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum fructicola (strain Nara gc5)|TrEMBL
MASPLDRPGILSVLNNFHDVWQEIRIPVILFTAFGLLVLRFYLHSVEEKDELKAFPKALN
REKPESKPLPKPVDEKKDAKPTPVVETKAPKSNGPKRIKGGLVKRPSEELKNGEASTRTV
RPLIFFSSITANTPKIAKDYAERLEKELEKVTADTDCSFNTPEVLDLAEIDFDDYFITPP
KSEDPVELFYMFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREG
WPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYVERLSEWSEGVVDVLGMLAK
TGSLGEGLPGSGAPEESDDESAAEDDDEVLIEEDAKPEKLKSRKNIDDVEDLGRIMKSSN
PDADTKPAAAPIAVDFTTYGKSASAPKKTPTNAAKEMVPKNSPTYASLTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINE
FLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERF
QRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYCGTSTA
SNAGLSMSNVPFYWEVAEFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKDGKWH
PRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A0P1KTJ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea quebecensis|TrEMBL
MSLSTNLTDHLLVCAVVAVYLISGGRVSIGCSIVVLYALSMYDSAKNLKVSEAESDQVSL
EGAEKQKKKTCCGGKGGSSCCSSGGSGKKGGCCGGACASKKKAQEELTLTSPNPEPSVDE
PIAIDFTHAFKPARSSKSKTGTKKMPRLISRTAGGAKKDTGFFKKALTVSNEKLSNSQIY
VFYSSLQGAAERSAKTVLETLSGMPELKRTPKLLNLDDLSDFDDYFVNVPGPDALYILVL
PSYDSDSPLDFFLQSLQENANDFRIDKFVLRKLVGYAVLGIGDSESWPEKFCYQARQADL
LLAKQGGRRVFPVGEICMKFGGDPKVAEWSKLLSETLRDDEPILYEYDETLDDEEPQGPE
DELTKEPLIDLEDVGKSSELQDVSSVKKMIGKDSPTFKNLTKQGYTVVGSHSGVKICRWT
KNDLRGRGSCYKHSLFNIVSSRCMELTPSLACSSKCIFCWRHGTNPVSKTWRWEVDDPEY
ILENALQGHYAKIKQMRGVPGVIAERFAKAFKVRHCALSLVGEPIMYPFISKFVSLLHQK
EISSFLVCNAQHPEPLRDLGKVTQLYVSIDAPTKNELKKVDRPLYRDFWERLMECLDILR
TTQSHQRTVFRMTLVKGFNMADVSAYADLVQRGLPCFIEVKGATFCGTSDGNGNPLTMQN
IPFYEECAKFVKSLATELQRRGLEYDVAAEHAHSNCILIASTKFKINNEWHTHIDFDKFF
ELLNSGKDFDHMEYLQKTPEWALFGNGGFAPGNTRFYKKKRGQEIQDKEGQNLPESANTQ
PIVV
>A0A3Q1F706|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acanthochromis polyacanthus|TrEMBL
MSVWHNRLYVYSAAALLFGVWFSLKMTLKNVNWQLLHAKMTTLQCLISFSFYSSFVQGFA
HELSEEVKTLGIPAEAIDMKDYDPDDQLADECVSKSVCVFLVATYTDGQPTENAEWFCKW
LEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGD
CNVVKSRNGSVQADFQAWKVKFVNRLQALARGEKKSCSGNCKTGGSCKNKKKEKQEEERE
ELIESSSDEEESSPSDEKKSGSVVDVEDLGNIMNSVKKSKVRLPVYSYEALFFPRCSLSF
CAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQFRGVPGVKPERYEEGLSVKHCALSLV
GEPIMYPEINAFIRLLHFHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWPRFLGSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGV
TYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGE
WWTWIDYERFQELAKAHEESGGQQSFSAMDYVAKTPSWALFGAQEQGFDPADTRFQRRNK
TKDISGC
>A0A498H9A8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus sp. WG1-DM|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A5C0SMC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus aciditolerans|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPSQLYVSLTAPDIETYNRVNVPMVPDGWEKIKETLRLMKDAQTRTVIRLTLVKDE
NMHSPEGYAELIKLANPMFVEAKAYMFVGYSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTGIGGRFIKH
>A0A421J691|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Meyerozyma sp. JA9|TrEMBL
MFGKALFSVCCALYLLSGGRWTFALAGFIILALASTKKPKKNSTLSPKTTSTKKRQSPIV
AVDFTTSSISSRSAPTASTRTRPVPRKRTPKIFKGSRPSAEEPSSSLTESTNLSTTKIHI
FYTTLTGTSLRVAQSLQSELKSLKLEFDPKLVSLDDDVDDLEEYFLRCPPNSLYVLVLPS
YETDSPIDYFLEHLRETYNDFRVDKYPLQKLVGYAVLGMGDSESWPEKFCYQATSADKWL
AKLGGRRVFPLGKMSIKHQGEEKAQEWIEQFSRLVADPEPFYLDREIEDSDNEAGSDDAD
TLVDVEDMGDIIRKSGDKPEVKQMVAQDSPTYKSLAKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSTWRWELDPPEKVFEG
ALEGHYKKIKQLRGVPGVQMDRFQEAFTVRHCALSLVGEPIFYPYINELVGMLHASHISS
FLVCNAQHPDQLAKLAKVTQLYVSIDAPTRTDLKKVDRPLNADFWERLMSCLDILRTVQS
HQRTVFRLTLVKGFNMNDVASYADMVERARPSQIEIKGATFCGSSNSNGNPLTMQNIPFY
EECKSFVESLAQELQARGSDYQIAAEHAHSCCILMAHGKFKINEKWHTHIDYPRFFELLE
SGQDFVDLDYVKETPEWALWGSDEAGFFPDDTRFDRKAEKLRRRLEREEMEP
>A0A1Q3AT06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cephalotus follicularis|TrEMBL
MTKSILTMSSPSLTTRLTLLALLSASTFYFLFKSRRLKLLKTLLNPNPNFTLSSSNPKIF
FLSQTGTAKTLAHRLHTYLSLNNFFFDLVDTHNYEPEDLAKETLVLIVASTWEDGKPPQS
SRFFTSWLVESAHDFRVGSLLLSKCRFAVFGLGSRSYGDTYNAVAKDLSVKMRELGGVEM
LNVGEGDVDGGDLDGEFEDWCKQVVAVLKRDNDSHNSNNMVENGVALENGIEESDYELVD
EDEQNGLQSEVVDLEDIAGKAPPRTRSTVTGLVAETNGKMNGKRDMVTPVIRASLEKQGY
KIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGKSWQWKMDDPLDIVNSAIDLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPI
MYPEINALVDELHCRRISTFLVTNAQFPEKIENLKPVTQLYVSVDAATKESLKAIDRPLF
GDFWERFIDSLKALKAKQQRTVYRLTLVKGWNTEDIDAYFNLFSIGNPEFVEIKGVTYCG
SSATSKLTMENVPWHSDVKAFSEALALKSNGEYEVACEHAHSCCVLLARTEKFKVNGQWF
TWIDYEKFHDLVASGRPFSSRDYMAATPPWAVYGAEEGGFDPDQSRYKKERHHKSNH
>A0A895A8Z1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium sp. GSL-19|TrEMBL
MSESDGPKQVDDPDYHHENHTAAQTCGWTANAMRGEGTCYKHAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHSGHTYELDGVAWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEAM
EPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPAVLRECDPTQLYVSVDAP
ERATFDDVVGATEDDAWERLVDTMDVLHAKDDTRTVLRTTLVGGQNMANPDWYAGFFERA
APDFVELKAYMHVGDSRDRLGRAAMPDHEDVLAFARAVKTHLPHSVLREQPASRVALLAR
DEDTWVEDLRPESAFWTEGARPTAD
>A0A3N6MBC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrarchaeobius halalkaliphilus|TrEMBL
MSDSADSGAQAASDGHQDGGKRNDGDGSDDGDGGPAQVSSPDYHSENHTAAQTCGWTANA
LRGEGKCYKNIYYGIESHRCIQMTPVVRCNERCVFCWRDHKGHAYEMDDVEWDDPEAVVD
ASITLQKKLLSGFGGNDEVPREVFDQAMEPRHVAISLDGEPSLYPYLPELIEAFHDREIT
TFLVSNGTRPEMLRECDPTQLYVSVDAPERHTFDQVVKAMEDDAWERLLETMDVLAEKDD
TRTVLRTTLVDGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSSMPTHEEVI
EFAESIKEYMPAFTECMGVPASRVALLSKTRDTWVPKLEKDSEFWARDPVTGD
>A0A662WCT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobales archaeon|TrEMBL
MEEKPEIERTIPQKLLKDLKGYQIVGSHSAVKLCLWLKKSMKDLGVCYKQKFYGISSHRC
LQMTPALLCNQNCIYCWRPRELLPGVKGWDPPEFIAEESIKAQHRLLSGFGGIKVNERKL
REAYEPNQVAISLIGEPTLYPYLDGLVEEYKARGMTTFVVTNGTNPAVIEKIEPYQLYIS
LTAYSEESHMALNRPAKSFWDRIMQSLKIMAEKDGRRVIRLTLIKGYNMDPEKFVPFIDR
ASPDFIEAKAYMHLGYSRLRLPRTAMPEHSDVKAFAEKLAKLTGYEVKDESEISRVVLLA
R
>A0A1Y2WGD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypoxylon sp. CI-4A|TrEMBL
MASSMGGHGLSETGSLKGIIELWHQHRPAILFATTCLLALVWLYIEFRQKNTTSEDPLKL
IQQTTKSGISIDDSRVLVEKVIPRTEKPKEPPAGPRRIKGELRRTESARKDAGSAHKKPI
QVLVFYSSLTGGTERTVAGFAQALEALLRLQGSDSENVFLKPAVLDLAQVDCDEYFISAP
KPADPNTPVDYFYLLLVPSYNIDSINDNFLEHLQETYHDFRIDTTSLSGILGYSVFGFGD
REGWPTEDEGFCFQAKEVDKWLARLTGRKRAYPLGMADTKRDLKERLDEWTDGVKDILKH
ISDTGSLGEGVPGSGDAVESDDEYGSGDDDDGEVLIDESVTAKKSKKGNSGNIDDVEDLG
RIMKASQGNSERPKKSGAIAVDFTTYGKSTSKKPMQTVKEMVPKNSPTFASLTKQGYSIV
GSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVG
TTWRWVVDPPEMIFNGVKAGHYQKIKMLRGIPGVRAERFAEAMRIRHCALSLVGEPIFYP
HINEFLALLHGERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDF
WERFQRCLDILREKRFKQRTVFRLTLVKGFNVEDEVEGYANLVEKGLPCFVEIKGVTYCG
TSSSAGAGLSMANVPFYAEVTEFVTALEKKLRERGLEYGIAAEHAHSCCVLIASERFRVD
GKWHTRIDYQRFFELLEERGADGDWTPEEYMGPETPEWATWGNGGFDPRDQRVDRKGRKI
EA
>A0A7K9VEL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anseranas semipalmata|TrEMBL
LDVSMDMWNFSYTCLVSLWLHRFYIYSVIALGISLWIVVQFFTTKTKKKGEKSNGNLSSE
VVEDKLVNGYAALQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDY
DPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKF
LSCLQALCRGERKPCSGKCKKGKCKSQGKQSNESSDHEHRASEYENTEAEELVETSSEEE
ADAEEAGGTNSVIDVEDLGNIVSHMKKAKRERELEGDVGTSLSGEAAERKEAGEKREMIT
AALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHRNMIKQFKGVSGVKADRFEEAMTA
RHCALSLVGEPIMYPEINRFLKLLHQHDISSFLVTNAQFPDEIRNLEPVTQLYVSVDAST
KESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLVSLGKP
DFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVQELAELIPDYEVACEHEHSNCLLIAH
KKVRL
>A0A7C3VAP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MISEEERKVLRRQGYKLFGRNSSAKLCHWTRKSIYGEGVCYKERFYGIHCHRCIQMTPAT
TSCTHNCIFCWRAGDFSKIEVNDPDEPKDIVEGSIAAQREIVSGFGGEARADKKKWMEAR
EPKHVAISLSGEPFAYPLLGELISEFHNRRMTTFVVSNGTFPERLAELNPLPTQLYLSLV
APSEDIYSRVCAPLISDGWGRLNESFALLNSLPCRRVIRITAVKGFNMTNPNGYAKMILK
AEPEFVEVKSYMHRGSSIHRLAQSNMPSHNEIIEFAKSIAAESGYTFADESPPSRVVLLA
RDEKAARSRVIAFD
>A0A7S2RFR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizochromulina marina|TrEMBL
MSGTRFAVYGLGSSEYESNWCRAAVDIDSAFRSLGSQSLLSAVGKGDDSTDIQGHFREWR
KSVLSALGAGGSQAAGSGGGKSTSSSQATECCGGSGEGTTSQDCGCSASGDGSPTRKKRA
EGPVHKVKPKRIKVQRPVGGKRGAADAATEAVVRMPEDMVNELMLDITVDSDASDTESLK
EAAPQSASAAGEVEGMVDLEDLGSTMAASSAHVNSISRSLASTDPASRPEMVTPLQRQSL
TKEGYKIIGSHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVFCW
RHHKNPVGREWRWRTDEPAAIVAEGVDKHVKMIHEFKGAKGVKPERLAEAYTVRHCALSL
VGEPIMYPRINELIRELHKRRISSFLVTNAQFPDQIRNLEPVTQLYVSIDAATKDSLKAV
DRPLFKDFWERFLECLRQLREKQQRTVYRLTLVKSWNMEEVDQYVKLLEIGQPDLIEIKA
VTYCGTSDASSLTMSNVPWHHEVLAFAQAIADRHAKSVAALGGPAEGRYGIATEHAHSCC
VLLARRDIYFSSPDDQPGAEPRWRTWINYDRFHELVDQYYQDGTRFTSADYLADTPSWAI
YGAEERGFDPAEVRFRKNRKGEKVPLEYKASESGCG
>A0A665U0Y7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
MALKKKSISKDINPWVYKAVKIQNCPDRAAVVHVSGVKIFYGSQTGTAKGFAKELSEEVT
NLGIPSEVIDMKDYDPDDQLPDECTSKSVCVFLVATYTDGQPTENAEWFYRWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGMRVMTRGEGDCNVVKSHN
GSIQADFQAWKVKFLNRLQALAKNEKSCSGNCKTGSSCKNKRNDGQLEVEKENASPQNAV
AEVMAEKLHLDYLSLNISMKKLADEEERREMITPALKEALTKQGYKLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEK
ILQDSLEKHQNMIRQFRGVPGVRPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSH
QISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALG
EKRQRTVYRLTLVKAWNVEEMQAYSELIAMGQPDFIEVKGVTYCGESSASNLTMANVPWH
QEVVAFVQQLAGMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYQRFQELAHVHEE
SGGLQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A662H3K7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVIKKTQQALYQTYRKLDILRLVYRRLGYHFAGVQAVVKPCHWLKKSLLTRGKSFCYKQL
WYGIPSHRCLQMSPVIVCNFQCLYCWRAHESDLHLTPIDPKMYEKIPYDPPKRIVDETLR
AWRSILAGFKGNPKVDPKMFEEALNPIHVTLSLTGEPTLYPWVGEVIDQYFKQGFKSVFL
VTNGSMPQVLRELKREPSQLYVTVPAPDRHTFRIITRPLIPDAWERLVETLRELENIRPP
TVIRLTLVKGLSLKNPEKYAELISLARPTYVEVKAAMSVGYFRRRLNKDNMPKHAEIKQF
AEKLSDHLRKDGYKIIGEFLPSRVVLLSTLEQPMKIIGEKG
>A0A662J3V9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MPIPEALAKMLRQQKYQLIGSGWTAAVKKCHWLHAALTSNKFCYKNWYGIESHRCIQMTP
VLACPNSCLHCWRVERGDLGGQVKWSEEDLMTYDDEHELFNQAIRAQFRILTGYKSNPKV
IRERYIEALHPKHFAISLAGEPTLYPKLGDFIKLCRSKGFTTFLVTNGMYPQRLLKLLDG
GQPSQLYLSVNSSSEEEFKALSRSSLPDGWSRLLESLSLLKHFKCPTVVRITLIQGVNDH
DVDGFAKLISLGEPWYVEVKGYMYLGFSRFRLKLENMPRHKRIVEFAEKLGEAIGYKLVA
DSLSSRVALLSRIGSPVKVKP
>A0A662I6A9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MRDAYKKQGYHFVGVQAVVKPCHWMKRSLLTRGEKFCYKQKFYGIPSHRCLQLSPIIQCS
QRCLYCWRAQPQDLGIDYNELDVKVYDDPYTIVENSVKEWQKILSGYLGNPKVDPVMLQE
AMRPTHAAISLVGEPTMYPKIGELVEAFFEYGFRTTFIVTNGNFPEVISNLEKEPSQLYV
SLSAPDEETFRKVCRPMLKDAWKRVLKTLELLKSLSCPSVVRITLVRGLNMKGIDKYAKI
LSRAEPTYIEPKAAMSLGYFRYRLGVEPMPRHEEIRAFAEKLAEYTGYNIIDEAMDSRIV
LLSRLNKPLKLM
>A0A0L8R9M4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces eubayanus|TrEMBL
MDGFSLAGAVSVGTLIAAYLYFGGRFSIALVILVGYGIYCNEAGGQVEEKVISSPEKKKS
CCSDKKNADGEKTGGCCSEKKKNGAGGGGCCSSKDGKKKSGGGCCSSKDGKKGKGGGCCS
SKKKTSNDEDENENVDVVPQVQESKNFPVTVDFTDVFKKPTKKRSGTPKVFSKNNSSKSK
IGKKLSVSKKIGQDGLIKTALTISNETLLSSQIYVLYSSLQGAASKAATTVFDKLTGLDE
LVNKPKLLNLDDLSDFDDYFVDVPAENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVD
SFPLRKLVGYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGEICMKTSGNTKI
DEWTSLLAETLKDDEPIIYEYDENADSEEDEGEEDNGSDELGDVEDIGGKDNNGKFSSAD
EIKQMVAKDSPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCM
ELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIA
ERFAKAFEVRHCALSLVGEPILYPHINKFVQLLHQKGITSFLVCNAQHPEALRNIVKVTQ
LYVSIDAPTKTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVS
AYADLVQRGSPCFIEVKGATFSGSSDGNGNPLTMQNIPFYEECIKFVKAFTAELQRRGLY
YDIAAEHAHSNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALF
GNGGFAPGNVRVYRKDKKNQNKENQEIQKIKAPLPPIPV
>C1H3B2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01)|TrEMBL
MTGIVLGLLSLWHKYRIPILFLAPVVLAVVRLLPKYPTSDPSHSSGSSPSPSSKETINSG
DVQDRELLLSKTEPPSATLTKHDPSRSSSPDSDKRTKRTLNGPKRVHGTKPLKNDVNRLT
GHARLPQDIAIQPLVFYASLTGSTEAYAKSFCDRLQGVAQSSLNNGNGIFLAPQLHDLSY
IEFDDFFIAAPNPTDSAPNTKFFYCILIPTYNVDTMINTFLDHLNETHNDFRINTSPLSG
LVGYSVFGFGDGVGWPTEEAGFCSQAKEVDRWMAKLTGKKRAYPLGLADVKGENLQIVLS
EWCDGLSDVLSDLVALGGGLGEGVPGSGDPIESDEEEDIDGEPTENKTNGGNRLKKDQEQ
QLIVDMEDIKFAISDEKKTSADSQLLPIDFTTQSGTQSFKPAAQLEMVPTSSPTHAALTK
QGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRH
GTNPVGTTWRWRADPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVG
EPIFYPHINKFLELLHGEHISSFLVCNAQHPDQLATLDRVTQLYVSIDASNRESLRKIDR
PLHRDFWERFQRCIAILREKRYFQRTVYRLTLVKGFNVDEEVVGYADLVEKGLPCFVEVK
GVTFCGTSTSASAGLTMKNVPFYEEVVSFVVALNAELSRRGLGYGIAAEHSHSCCILLAS
KRFFVNDRWHTRIDYDKFFILLQREKSDGIQFRPEDYMRETEGWALWGNGGFDPNDNRVY
TRGKNKAKQNATIEESQAQGASVNG
>A0A5E4JZJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MIPEKVKEVLRKQHYGLVGKHSAVQICRWTKKSLREEGVCYKEKFYGIKSHLCCQMTPAV
MWCPNKCLHCWRAIEMTIGDELKGKVDSPKEIIDGCIKEQRRLLQGFNISEKSKKKQLSR
ANQKKYSEAQEPMQFAISLSGEPMVYKHIGGIIEELRKRGKTSFLVTNGLYPEKIKELEE
KKQLPTQLYISVNTPNKELYEKFHRSSKKDAWERLNKSLEIMSNLRKKTRTVFRMNLVKD
LNMITPEIYAEMIRKANPMFVEVKGVMSVGFARQRIPYEKMPYHKDIVNFSKKILKFLPG
YKILAEKKESRVLLLGKDKEEMKIREI
>A0A5E4JCD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MNKRELLADFAHKKYGFFEDASVQVCEWNKKSLRGQGNCYKQDFYGADTISCHQIAPTTF
WCNNSCVFCWRPKEYMKGTPKKTADPKKMIEALIEERRNLISGFGGHDKVSKETYSRARE
SRHWAISLSGEPTLYKKLPELISLLKKRKGTETVFLVSNGQNPKMLQKLWSESKKAKSEN
ENSLPTQLYISMVAPEEKLWKGITLNREKGGWKKYLRSLALLKLLPCRTVIRLTVIKGMN
DSKETQEKFAELLEAVQTDFIEVKSYMWLGLSRKRLTAENNPSHEYTKDFALSLLKRMPS
YKFESEKANSRIALLKNKGSKYKTKIIERN
>A0A3R7YCY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED141|TrEMBL
MDPTLKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLTGFGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYTRLAEYMDLCHQHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQIFDDVCRPKWNSGAWEQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAALDR
RADPDWIEAKGYVYVGHSREHLSIDNMPSHEDILAFSESLAPQVDMRILSESRPSRVALI
GNEMVPIPIPEASMHFPEDLGIASPVKKLKLADLS
>A0A5E4KUY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MTFISDSTKFLLKKHGYHLAGTHGAVKTCLWLNKSLRSEGGCYKSKFYGITSHCCIQMTP
TLVCNHRCLHCWRAIESPVDVPEQWDSPQEIVESCLAEQRRLVSGYGGSETMDKAKWKEA
FEPKHVAISLSGEPTLYPYLPELIDEFHKKNLTTFVVSNGTNPEMVGKIKPTQLYISLNA
PDRETYSKVCAPLGDTWGNLKQSLELMKDSRIRTAVRTTLAKGVNMTNPEGFARLIALAE
PEYVELKAYMHLGFSRKRLAQDNMPSHEEVLCFSEKVAQALGYCIADEAVNSRVVLLSKD
GAKHNIV
>A0A7L0BUX7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spizaetus tyrannus|TrEMBL
LDVSMDTWNFYTCLVSLWLHRLYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASFE
GIEDKVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDY
DPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKF
LSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKDCSDHEHGASEYENTEAEELFETSSDEE
ADGEEAGGTNSVIDVEDLGSIMSHMKKAKRERELEEGDTGTSLTHKNAGRKEEGEKREMI
TPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMT
AKHCALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDAS
TKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGK
PDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIA
HKKFKINGEWWTWIDYDRFQELVREHERSSRSKTFTAADYAARTPCWALFGSRERGFDPL
DVRYQRKNKARDISGC
>A0A5E4JIP8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MDKTVYEKRRYKMVGSHSAVKLCTWTRNSLVGKGHCYKEEFYNVKSHRCLQMTPVVAWCE
HSCLFCWRPCEFTQGTSMKDVKIDEPEDIINNAVEAQRKLLIGFKGNDKTPKKMYEEAIN
PNQAAISLAGEPTLYPKINGLLDIFKKKNFTTFLVTNGMNPKVLEQLSPLPTQLYITLVA
GNPKDYAKITNSCYKEKGFQRLLDSINVMKSLNTRKVLRLTLVKDYNMKNPGEYAKIIEN
SGCDFVEAKAYMHVGSSIERLGRENMPSFSEIKIFSKNLADELGWKIIDEQEVSRVCLIA
KEDYSWRKINKD
>A0A069DZD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panstrongylus megistus|TrEMBL
TNKEAIIRNSFIKKECKENGIIIPIKVLNVYYSTQYGRTKALCEQLPEISTIKINIFEMA
KVEAEEVLLRDANAPDIISLIIIPTVDDGKSPDNGSWFCKWLHEAATDFRIDKELYKGLH
YAVFGLGNSVYGENFNIIAKKLDSDLKKLGAKRILPLTLGNEDASNSINGSLEADFKSWL
QELKELIKHSEISSSWLTQKVSNEDSSDGEENDKDNVVDVEDLVKITNKKESLKEKEMIT
PSLRQTLSKQGYKLVGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIQSHRCMETTPSLACA
NKCVFCWRHHSNPVGTEWKWKTDKAEDIVNDALKNHYNMIKEFKGVPGVLFPRFEEGLIA
KHCALSLVGEPIMYPEINRLIRLLHERQISTFLVTNAQFPEAIANLDPVTQLYVSVDAST
EESLKKIDRPLFKDFWKRFLDSLKELSKKGQRTVYRLTLVKAWNFDEMQNYANLVNLGNP
DFIEVKGVTYCGGDNTGPNKLTMANVPWHEEVVSFVQQLTSLLPNYEIASEHEHSNCLLI
AHKKFYIAGQWHTWIDYDRFHVLMQSYCKTEGSQNFTTLDYTSPTPSWAVFGAKERGFDP
IEKRWFRKSKKDISGC
>W9RQ06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Morus notabilis|TrEMBL
MAKPEKLLPAMCISSVPARLTLLALLSATTFYCFYKFHRLRSLRISLNPNPNSKSSSCFR
RGKLLFISETGTSKTLARRLLDLLNSNDLAFDLVDAKAYEPEDLPKETQVLIVASTWEDG
KAPPSGRFFANWLAESVEDFRVGSLLLSQCKFAVFGVGSRAYGATYNVVARDLSKRMRGL
GAAEMLPVWEGDVDGGDLEEAFDAWSAKMVKVLNDDVVENGGALSNGVGAESDAESDYET
DEEYSVESEIVDLEDIAGKGPSRRSPVVVQTNGTSNGKKDMVTPVIRASLEKQGYKIIGS
HSGVKVCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WQWKMDDPLEIVNSAIDQHTKMIKQMKGVPGSHFGRGDLERPEWAIQSGLLWTSVSEAWW
YLGSWLSPTLLKYGLSISSCAGVTLERLTEGLSPRHCALSLVGEPIMYPEINTLVDELHR
RRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLKAL
RDKQQRTVYRLTLVKGWNTEDVDAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPW
HSEVKAFSEALALKSQGEYEVACEHVHSCCVLLAKTEKFKINGQWFTWIEYEKFHDLVAS
GKAFDSKDYMAATPSWAVYGAEEGGFDPDQSRYKKERHHNRPNRATARPVFTLFLIKKCV
FPSSTCSKFYKRELLYPSSIAFSAQLKSGYNKLPIGTGVRAAWVPLKESVNSRIALDK
>A0A8H8U1B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachnellula hyalina|TrEMBL
MYHDTWSLRALWNVYATDIFALWHTYRIPIILSTFAVLIIIRTILHLRVNREKISDTPPP
LSPTLQAAKDKGAVEYLEKKTNGEKVPRRIVGGLKKRKSSEENIVPREKKIQVLVFFSSL
TTTTEKTAKVFTEGLAQCAKDIASSTSTIFLEPEILDLSYIDYDEYFINPPKSDPEVQYF
YLILIPTYNIDTVLDNYLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPSEEEGFC
SQARDVDKWMAKLTGRKRAFPLGMGDPKTDAVERLREWKEGVEDTLRHIAETGSLGEGVA
GSGDAVESDVEDVDDEDDVLFEEQKLAKRKNKEKKGDLNDLEDLGGSIPKAEDETLEVDF
TTYSKKPSTTTPIIKEMVPKNSPTYNSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYK
YSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPDLIFSGVKAGHYQK
IKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHAEHISSFLVCNAQH
PDQLAALAPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRARRFEQRTVFRL
TLVKGFNIDDEVEGYAKLVEQGLPCFVEIKGVTYCGTSSSAGAGLTMQNVPFYSEIQAFV
VALNTALEKRGLGYGIAAEHAHSCCVLIASERFRNERGKWCTRIDYEAFFRCLESGKPFR
PEDYMGEETPEWATWGQGGFDPRDERVYRKGKNKVPLKEVGEKGEEGKLVEI
>A0A8C1PZM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MPLIVCLHKCANYIPVHSFTGALNDVWEFTESYLLTVWQNRVYVYTTAAVLIAVCFTVNM
LFKKKKMVDAVSPLLDKSVKNQKHSPEAEKVIHVSGVKVFYGSQTGTGKGFAKELAGDVI
AQGIQCEVMDMKEYDPEDRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDF
RYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRH
GSVQADFQAWKTKFLNRLQALAKGEKKACSGKCKKGSCKNKKKHKEEAEDSHSLAEKNNS
EEELMESSSDAESSAEEEKSHGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYSLWYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPV
GTEWSWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMY
PEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKD
FWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGES
SASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWID
YERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISG
C
>A0A7J3D3B3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSTYPTQLLQKLKVQQYHLAGSHSAVKKCSWLHKSLVLDRVCYKEKFFGIKSHRCLQMSP
SLFHCNLRCLHCWRIMPEDLNLDWDELSPPLKGWDEPEKIYEESIKAQRRILSGYKSLVL
KGRILPRKYEEALHPNQVAISLTGEPTLYPYLSDLIHLYKKNGFTAFLVTNGTLPHALSN
LDTLPTQLYLSLTSYDRDSFFRLNRPISVYLWNSISKSLSMLNSLGCPTVLRITAIKGLN
IEKPEAFAKIINKYEPLYVETKAYMNIGYSIYRLSKENMPLHEDMRSFARSLASLTGYNV
IGDSKDSRVVLLSKKLSTPQRFN
>R1GMS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryosphaeria parva (strain UCR-NP2)|TrEMBL
MASSNPLRLVSDDLLSLWHTTRVPVLLTVCAVIALARLVQRLRQPREKLSASPIPGSPTS
KVEDIAAPWVNAEIIPPISEKPAKSIDDGHVEDITIAEQPLVRPKAGPKKVTGTKVARQI
AKRVSSFDAARDKVQPLVFFSSLGGTTEAAANKLAEDLGLWIDALESESTAAPLKPQIHD
LSYIDYDDYFISAPKGEKNTKYFYFVLLPTYNIDTTLDNFLEHLQETHHDFRIDTAPLSG
ILGYSVFGFGDREGWPTEEEGFCSQGKDVDKWLAKLTGRKRAYPLGIGDVKSDAQERLKE
WRLGVQEILLDVVAGKGLGEGVPGNGDAVESDEEDVDDDDAESDTSQPSKPRRTKAKSNL
DDVEDLGKMVKNEINPDEPMEVDFTTYKKSARPITTSAPKEMKIFEGVTEGHYKKIKMMR
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFMALLHKQHISSFLVCNAQHPAQLA
TLKHVTQLYVSIDASNKESLRKVDRPLHRDFWERFCACLDILREKRFEQRTVFRLTLVKG
FNMADEIKGYADLVARGLPCFVEIKGVTYCGTATSAAAGLTMQNVPFYAEVQEFVEALNA
ELNSCGLEYGIAAEHAHSCCVLLASTRFRKQVGGEWKWCTLIDYDRFFELLESGEEFKPE
DYMGEPTPEWALWGNGGFNPEDERVYRKGKNKEKAAVEEGSKAVVEI
>A0A167XTC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Moelleriella libera RCEF 2490|TrEMBL
MSDRRKRGADDVIDLTRDSDGSRAKKSRDLPAKSPSGIDGTFVYRAAGDITFSTASVGEG
SSLSCSQVSNPSQIGARDGEAWDSTQEDDDRVRELYGSFDTKVVGIQYYKGHASEGEVVL
CKREPHNQYDRNAIRVDNVMSHQVGHLPRKVVEKLAPYIDSGDIIVEAQLNGRKNPYDCP
VRLSFYGPSDPPERTRIEHSLKADKLVKATELKRTKKDAEAQRTIMGLKAGGATYGMGAS
AIEEPEISLEDILKYSEFVGFKNGTDAIKTFSMDEKSLSEMPMSAQPAALRSTLLPYQLQ
GLAWMTAKENPSLPKKDLGNIVQLWKQDGRGYYWNIATDFVCQSPPTLLSGGILADDMGL
GKTLQIISLILTGGRGTTLIVAPVSVMSNWKQQIERHVQSECAPSVIIYHGDKKMAGSQL
MTFDIVITSYGKLARERDAGVPQVLLASEWKRVVLDEGHTIRNSRTKVALAACALQAKSR
WVLSGTPIINSVKDLHSLVKFLHITGGIEQAEIFNTKVTRKLSAQDPAAEAILQALLQDI
CLRRRKDMKFVDLKLPEKKEFLHRVTFHPEERKRYEVLLGEARGALAEYQAKDTGGKGQF
QGVLERLLRLRQTCNHWKLCRDRIDGLMKLFEGQDIVPFDKANKALLQQALRLYIDSQED
CAICYDIPSGPVITNCKHVFCRICIQKAIQMQGKCPMCRNELSEGDLLEPAPEGTLDQSF
DTTAQSSKTVSMMQILRATLTKDPGSKVVVFSQWTSFLDIVQRELKAAGMRFCRLDGSMN
TDSRDRAIQALDNDAETRVMLASLAVCSVGLNLVSANTVILSDSWWAPAIEDQAIDRVHR
LGQTRETTVWRLVVEDSVEERVLHIQEQKRDLVNKAFQDRDKKYIIEVWHSHRTPLILSA
LVVLVVLRMCFHYNDRSGSLKVLPEHVEEKSYAPTRTTKRQATFQAEKPLVPTTGPRRIQ
GGKSKRLPIEETKQHNNDRPFKVWVFFSSVTTKTEKIAQQYLKTLEKSTVRLSHETGRRV
LSPELRDLAEIDFEDFFTSPAKSAEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRI
DTAPLSSLLGYSVFGFGDKEGWPNEPEGYCFQAKELDKWMSKLTGKKRAFPVGMGDMKGD
HVQRFEEWTGGIQEVVAHVARTGSLGQGVPGSGDAAESDVEEAIDYDDGETMIGEEMSAT
EKEPPQPLNDVEDLGRLIRPSDPKPKSRGTKVSLAVDFTSYGPGNEKRDRVAAPVTKEMV
AKNSPTHAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSL
SCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFEGVKDGHYQKIRMMRGVPGVRAERYAEA
LRIRHCALSLVGEPIFYPHINEFLEMLHGERISSFLVCNAQHPDQLAALKAVTQLYVSID
ASNKDSLRKIDRPLHRDFWERFQKCLDILRVKRFRHRTVFRLTLVKGFNVEDEVEGYAQL
VERGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFVRALEKRLKEKKLEYGIAA
EHAHSCCILLASERFFVDGKWHTHIDYEKFFQLLEQRGPEGDWTPEDYMGKPTPEWALWG
NGGFDPRDDRVDRKGRKMDNVVIREAPLPKGVQ
>A0A1B1E1D2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium coatneyi|TrEMBL
MVKMDEAKKRRNLLQTIFEQHAVRKKKKAKINLRIVYGSEGSNSYKKAKGFLNEFIQFFK
DIENICNEVNRIVTEEGGSHHIFNGRKNELYHGDDNRLVKYFKEYSELLQRKNEQSGRNG
KKDSFKTERVNAAHEALQEFQEKEKKCSDKFVNYLDCCISNNVCTVNFDFVNGNEFNDYT
FFERTSEYDLNVMVLFVSTASNGSFPRNCYKFEQLLEDLFNDFRVEKDFLKNIFYTCIGF
GNKQYGSTHFCAPVKKCDKYLTSLGAQKLFRTLKLCDEENNEETFLLWKCSLFKTISLGF
LFYCFNFPQLGSFMPYADRKIYNSLQHYCFFFCAKGENRKGRDENFRVGSRTDVASIEVP
YQGGQHNHVTVQKRESPQAVDPPIEDTLKVDPPTNASCSTCGEGTHNGCTPPNGDEWEEV
PTAQSSDDEMVEKSPHSYGIKKREDVKASTSLCSSGDELEDLIPDKPKDMLTSNQRNKLT
KEGYKIIGSHSAVKLCRWTKSHLRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWR
HHKNPVGTHWKWNKDDAEMIVNEALKKHKGMIKELKGAHGVVKERFDEAANVRHCALSLV
GEPIMYPDINKLIDELHSKNVSTFLVTNAQFPNELQKLHKVTQLYLSIDAPNEEALKNID
RPLFKDFWDRYIRCIKILKKRKERTVFRFTLVKEYNMMSEEILSYSKLVEYGYPDFIEIK
AVTYCGSSDGYQLTMKNIPWHEEVYQFAYSLIHSNGYLSDSYEIACEHRHSCSILIAKKE
FKINDKWHTWIDYEKFQFLVRQNKDFTAADYCAETPSWAVMGAEERGFNPCDERVYTKGK
NKNKPPLTENTSQ
>A7I4Y3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)|TrEMBL
MPSTPCDARIRQGYLFFSPKSSAALKPCLWCKRALTGGDMCYKHQFYGIDSHRCVQMTPT
LRCNQRCLFCWRSFEHEVEEEEECPPETILAGVPKLQKKALAGYNSVLGNTVTDERWQEA
LKPRHVAISLSGEPTLYSRLPELVDLFNANGYTTFVVSNGTNPDMIARCRPFQQYISLDA
PDCETYERACRPMGNAEAFWDRIRESLGKLRAKRSAVRITLVAGVNDTDPEGYARIIQDS
GATYVEVKGYMYLGYSRNRLQRNNMPEHAQVRDFAERVSASCDYTIRDENPLSRVVCMER
EEQ
>A0A843K5D3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MQDTMAEKALARQGYHLVGSGAVKPCLWLNRSMRGGDQCYKNHFYGIASHRCVQMTPTLE
CNHLCLHCWRPIDDPIPGKEPMEPAELLEGILRGQQRFISGYGGSSTTDPVRLEEAREPK
HMAISLMGEPTLYPYLKEFIDLVSRRGMTSFLVSNATRPEVLAELRPTQLYLSLNAPDEE
RYRRICNPSKDLWPRILESLELLKEHRCRSVIRMTLVRGQNMEGLDDYARLIGDAEPDFV
ELKAYMHLGRSRTRLERTAMPQHSEILALADSLAGLLGYHPEADVPLSRVALLSRGRISR
FIEMRDHK
>A0A7K8E7C2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leucopsar rothschildi|TrEMBL
DASMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPSFPEGA
ADKLGNGCVPPQALEVHVAGVKIFYGSQTGTAKRFAKALSEAVTSFNLPVEVINMGDYDP
EDGLVEETSSRSICVFLVATYTDGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFG
LGNSAYVDHYNTVGRRMDKWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKGKFLT
RLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHRTSEHENTEAEELFETSSEEEAG
GTDSVVDVEDLGNIMGHMKKAKVFLLQGEWNGAAGAGRKEEAEKREMITPALREALTKQG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPHINHFIRLLHQHSISTFLVTNAQFPEEIRRLAPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFIDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISIGKPDFIEVKGVTYC
GESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRT
WIDYGRFQELVREHEQSGGSRTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKARD
ISGC
>A0A815XGN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta ricciae|TrEMBL
MSVDLYLFAAGSALTALLFYAFIGAQWSMWHMFTIPLYIIIFLVFSSLSVLKRFKSSVKS
ETPTKSIVQEKNGITIAFASVKGNCRTFAQSTYDKLSNDLTRQVILQDLVDITDPEEFLQ
IQAKNQRTLLIFISTYEDATPPPSAKWFLMHLQEAATDFRVSKNELEKLTYAVFGCGNSL
YRDNFNKVAKEVDRCLAEIGAKRLVPTELADENTVKSTYGGLEGHYSKWTSQLKTALQSP
KTEKCDCSNDNSTTCCQSAANGEQATKQNDSDDNEQERIESDDDDEAGGCKNGGDDVMDL
EDMGDYIENTSMTKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAQTVCQGAIDN
HYKMINIFKGVPGVLPHRLAEGMQIRHCALSLVGEPIMYPHINELIDILHSKNISSFLVT
NAQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKGQRTVY
RLTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASNLTMANVPWHEEVVTFVR
LLCERLPQYGLACEHEHSNCLLLANTKFRIDGKWHTWIDYERFHELAARHKATGGKESFN
SLDYMAVTPDWAVVGSNERGFDPQDTRWHRKATAKKDLSGC
>A0A7J3RCE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MSEFVKHTPERLRKYRRAGYRIVGPNQHTGVEICRWAKSVLRGGRNCYKGIYGIASHRCL
QMSPCIDFCTFSCQFCWRSFGPNRAKAYPKWDSPKEILDAAIAAQRELLSGWKGNPKCDK
AKFEEAMEPKHVAISLDGEPTLYPYLAELIQEIKSRGMTAFLVTNGTMPQKLKELLEKGA
EPTNLYISVYATNPKGYAEICRPAIPDAWEKVLKSLALMKEFKSARTIFRMTLVKGLNLK
DPEGWAKLINLAEPQFVEFKGYTWVGESRARLKAENMPTMADLENFAKALLPHIGYEIIH
RDSVSRVIVFKKKNI
>A0A835TI80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salix dunnii|TrEMBL
MPLTSTPARLTLLAFLSATTVYCFYKSRRLRKISLNPNLNKPKLFFVSQTGTSKTLAHRL
HYHLASNNLHFDLIDPQNYEPEDLFKEKLVIIIASTWEDGKAPQNAKFFANWLAESAGDF
RVGSLMLSDCKFAVFGVGSRAYGETFNALAKDFSRWLRDLGAKEVVGVGEGDVDAGELDM
VFEEWSGRLARVLKGESVENGEVCGNEVVVIDESDDDEDDGGVESDIVDLEDIAGKGPSR
RSLVEARSNGKLNGENGKLNGQKEMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQLRG
RGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNSAI
DLHTKMIKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPEINTLVDELHQRRISTFL
VTNAQFPEKIQMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSLTEKQQRT
VYRLTLVKGWNTEDVDAYFNLFSIGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKSF
SEALALKSKGEYEVACEHVHSCCVLLAKPEKFKVDGQWFTWIDYDKFHDLVVASGKPFNS
KDYMAATPSWAVYGAEEGGFDPDQSRYRKERHHKTTH
>A0A5C6TIC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. cubense|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFYINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A842TT45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MPKLPKELKLLLEKQQNEVIGEHSAVKICTWTKKSLKDEGVCYKEKFYGISSHRCCQLSP
SMNFCQNSCIFCWRPIEHTVGTEMKGKIDDPKTLIDNAIKAQRKLLNGFPGNPKTNMKKF
KQAQDPNQFAISLSGEHTIYPKLGELIAEIKKRKATSYVVTNGMLPDKIKTLSPLPTNLY
ISLDAPNETIFKKVDRPKLKDAWKRLNKSLDILKTLDTTTVLRVTMIKGMNMIKPEKYAE
LIEKAQPDHVELKAYMFVGSSRHRLTIDNMPRHHEVKEFTELILKHLKDYSLKDEKKESR
VVLLKKL
>A0A397CVY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAKPVAVRILYGTHTGTAKGFATTLQQKLFALNVAGYAFEPSVVDMKD
YDQDNLEHEHVLISILSTWTGGVPPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLG
NSEYDEHYGKASKALSKHLSSLGASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGA
LRSPAASSSSSPSVKPKQQPAGWKSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIV
LELDQGDDSDDEDNRPKKQDSGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYK
IIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNP
VGREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIM
YPHINEFCRELHAREISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFK
DFWERFLSCLTQLKAKGQRTVYRMTLVKEHNMKELDNYVELIHLGEPDLIEIKAVTYCGK
SDASDLTMQNVPYHQEVRDFCELLCAKLGGGYELATEHAHSNCVLVAKTKFKIDGHWHTW
IDYDKFHTLIQAYYKDGTPFTTMDYIAPTPAWAVYNAPEAGFDPIETRFRRTKEGKVVEI
EYTATDSGCG
>V9KEW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callorhinchus milii|TrEMBL
LAAWVPLGLALLLLLLLGPRLLGAEQRREDHIFDVWSSLQSYLLSLWNSRLYIYCTIAVA
VGIWAAIEFLSKRHKKQNEDVKSSIVKQEVIENGHIVHEEKGVHVVGVKIFFGSQTGTAK
GFANTLLDAVKLLGLPVEVVDLKEYDPDDNLVDEIVSKTVCIFLLATYTDGKPTESAAWF
CKWLEEATNDFRYGKNYLKGLRYAVFGLGNSAYVGHYNTVGKHVDKWLWMLSAGRVLTRG
EGDGNVVKSKRGSLEADFSAWQVKLLSRLEALGQGDRKECSGNCKNGKCKSKGKKHKDES
RQKEAVPDERLEHSEEEELFETSSEEGSGSDSETGARSVVDVEDLGKVMNSMKRAKRALE
MGAEAVKPKLSKHVNGKSGSVEAREMLTPALRAALIKQGYRLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDEAEQILKEA
IENHQNMIKQFKGVPGVKAERFEEGLAVKHCALSLVGEPIMYPQINHFLKLLHQQRISSF
LVTNAQFPEEIRNLVPVTQLYVSVDASTQDSLKKIDRPLFKDFWPRFLACLQGLADKKQR
TVYRLTLVKAWNVDELKAYSDLIDVGKPDFIEVKGVTYCGDSSASSLTMANVPWHQEVVH
FVQQLADLLTDYEIACEHEHSNCLLIAHRKFKVNGEWWTWIDYERFQDLIAGYEESAGAR
TFSSEDYMAKTPLWALFGAKERGFDPTDVRFLRRKQKDISGC
>A0A674JLH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Terrapene carolina triunguis|TrEMBL
MLNFWLVFQVLTILAACADTHAMDASVDTWGYFYTHLMSIWLNRFYIYSCAAFGIGIWIC
FQFIATKAKKQDEKSTEKLTPSKVTQDVLINGYTMPKTKEVYVAGVKVFYGSQTGTAKGF
ATILAEAILSLNLPAEIINMRDYDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCK
WLEEAVNDFRFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEG
DCNVAKSKHGSIEADFSAWKARFLARLQALCKGEKKPCSGKCKKGKCKSKGKKSKEGSDH
EQRVSEQENTEVEDLFETTSEEELGAEEDGSRNSVIDVEDLGKIMGHMKKAKKECELEEE
AGRTGPSQQSSGKNEESERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREAIENH
QSLIKQFKGVPGVRVDRFAEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTN
AQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYR
LTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRE
LADLIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWIDYDRFQELVQEYENSRGSKTFTA
ADYVAKTPHWAVFGSRERGFDPLDTRFQRKNKTKDISGC
>A0A0J9VHL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax Brazil I|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSKLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSAHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEILSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>A0A6P8FS04|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clupea harengus|TrEMBL
MMFTKLTMLPLTLLADTVSYAFGAELPSNLDNVRRYTEGYVLALWQNRLYIYTAAAVVVG
IWFALNLVLKKKKVVRPASPWRFQTAETKKYPVKEKVEYVSGVKIFYGSQTGTAKGFARE
LAEDVKNLGLVSEVIDLKDYDPDDRLSDECTSKAVCVFLLATYTDGKPTENAEWFSKWLE
EASTDFRYGKTYLKGLRYAVFGLGHSAYEDHFNTVGTSVDKWLWMLSGSRVMTRGEGDCN
VAKSRHGSVQADFQAWKGRLLSRLQALARGEKKSCSGQCKNGTCKSKSKKKQQGAAAEAG
KCSSDQKPHSSEEELMESSSEAESVDDEEPGHGSVIDMEDLGNVMNLIKKVKKKAEGEDR
LKVRLSKLSNGKIPEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDPADKILLEAVENHQ
SMIKQFRGVPGVRPDRFEEGLAVKHCALSLVGEPIMYPEINAFLRLLHQQRISSFLVTNA
QFPDEIRSLVPVTQLYVSVDASTKDSLKRIDRPLFKDFWQRFLDSLRSLGEKQQRTVYRL
TLVKAWNVDELKAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQL
ANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYDRFQELVQAHEESGGARTFSAS
DYMAKTPSWAQFGGSERGFDPSDTRFQRKNKTKDISGC
>A0A6P6ED24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Octodon degus|TrEMBL
MDPSLDVWTLASPLVSLWMYRFYIYLGFALGISLWICFQVLTKKQLFIFKAKNSQEKSVP
KATQGLMTNGYIALQKKQTFVSGVKIFYGSQTGTAKGFAAILAKAVASLDLPVEVINLKE
YDPDDHLMEEIASKNICAFLLATYTDGRPPESAEWFCRWLEDAASDFRFGKTYLKGMRYA
VFGLGNSAYPSHFNKVGKSVDKWLWMLGARRVLARGEGDCDVVRSRHGSIEADFTAWKAT
FISRLQVLQRGEDKACGGRCKKGKCDSTPHGSEEPGPGPHSGGGSHPGDAEEQEPCESSS
EEDLEPGGHPGLNSIVDVEDLGKIMSHTKKEKGEKDHQEEKTSLFRNTRKGDDSEGRAMI
TPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAARFEEGLQ
VKHCALSLVGEPIMYPEINRFLQLLHCCKISSFLVTNAQFPVEIRNLRPVTQLYVSVDAS
TKDSLKRIDRPLFKDFWQRFLDSLKALAAKRQRTVYRLTLVKSWNVDELQAYAELVSLGS
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVGLIPDYEIACEHEHSNCLLIA
HKKFKIDGEWWTWIDYNRFQELVQEYEDSGGSRTFCAEDYMARTPPWALFGAREKGFDPK
DTRHQRKSRSKAIAAS
>A0A2S4PYY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Erysiphe pulchra|TrEMBL
MRCRKPPELALPRRLLHNLLAARTGHGDFATYHRRLKHVDAKLECVCGQETSPTHFIRCR
RHANQMRKLRNGMTIDTFRRKLLGYNRAKKFSEFARITGCFSDQISDSSSAVREENPVEL
WHYHRISVILTAITIFVAFKVLVYLRAARENKNFDYKSSIAVQHPALSPEKKEHVSDGQS
ARLGKNPRRIVGGLKKSVLTKNSYSSSQKIQPFVFFTSLTGSTKKTAEIFVDSLTTGLRK
LEKSQSRSFLDPELLDISDIDFYDYFLKFPNDEDVEARNFYLFLIPTYNIDTIIDNFIEH
LRETHNDFRIDTAPLSSILGYSVFGFGDREGWPTEDLGFCSQARDIDKWMAKLTGGKRAF
PLGMGDSKTDGQENLEKWKEGVEEVLRHVASTGSLGEGVAGSGDADESDYEESDADQSSV
EKPDPLRKKSKTQLKKYIQNDLEDIGRSLNVNSSDNTSQEVDFTTYSSKVSLTSKEMVPK
DSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSC
SNKCVFCWRHGTNPVGTTWRWRVDPPELIYNGVRAGHYQKIKMMRGVPGVRAERFTEAMN
IRHCALSLVGEPIFYPHINEFTDMLHADHISTFLVCNAQHPDQLASLKPVTQLYVSIDAS
NRESLRKIDRPLHRDFWERFNRCLDILRDRRFEQRTVFRLTLTKGFNMEDEIIGYADLIE
KSLPCFIEIKGVTYCGSTSSKNGLGLTMQNVPFYDEVCVFVQELDRELSRRDLDYGIAAE
HAHSCCVLIASKRFQRNGKWHTRIDYDQFFRCLESRKKFGPEDYIGLETPEWATWGRGGF
DPRDERVYRKGKNKVPFSLAIKPELEKN
>C5P685|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccidioides posadasii (strain C735)|TrEMBL
MPDETFASGAQRALSLWHSYRGYALVLLPAVFILSHLIAARDKTAEASPPSISSPPQSSK
AKQSRPTSGTEPPTSSTTPEEGTPSPNGAATRSKGRPPKRVIGTKPAKKGTKLVNGDSDA
TKEISIQPIIFFSSLTGSTERSAKRVLERLNTEPLKDSRHSSRLLAPQLYDLSYVDFDDY
FVSPPKAPESNPNVLYFYCIIIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYAV
FGFGDKEGWPTEEEGFCSQAKEVDKWMAKLTGRKRAYPLGLGDVKADGDKALDEWCSGMQ
EVLCDMVTNNGALGEGVPGSGDPLESDEEDVEDDEGVPNPGSRPRKARRAEITDLEDIKF
GGDASAKQGSDIPIDFTTYSKTSTSFATSTPKEMVPTTSPTYAALTKQGYTIVGSHSGVK
ICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVS
MLHSEHISSFLVCNAQHPDQLAALDRITQLYVSIDASNRDSLRKIDRPLHRDFWERFQRC
LDIIREKTHVQRTVYRLTLVKGFNIDDEVVGYADLVERGLPCFVEIKGVTYCGTSTSAGA
GLTMQNVPFYEEVAAFAVALNEELNRRGLGYGIGAEHSHSCCILLASRRFHVDGKWHTKI
NYERFFELLEREKAEGVSFTPEDYMSETDEWALWGNGGFDPNDQRVYRKGKNKGNMSDAG
SVPKGGVVEI
>L7JKB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Magnaporthe oryzae (strain P131)|TrEMBL
MSHPLGTTSSLGNLPSLILSVVAALILLRFYLEHTQGRDKSSVAFANKFGEENVKDGPSP
PPVETQKKSTSLEKTKPSGPRRIKGDVNKTGKNGGAQADITATGREILPLVFFSCVTGRT
DKVAREYAARLDESLRALPAVAGCSFRESRILDLSEIDYDEYFISVPKIEAQKEGSRVEL
LYLLLLPSFNIDTINDTFLEHLQETHHDFRIDTAPLAAILGYSVFGFGDREGWPTEEEGF
CFQAKEVDRWMAKLTARKRACPLGMGDSKTDAPERLSEWHDGVVDVLSLLARTGSLGEGV
PGSGDAVESEDEGGSNEDDDEVLIEENGWTEKKPKKSKSKALDDVEDIGRMLDTSRANGT
APPVAVDFTTYDKPKGGSRKQPAVQTVKQMVPKSSPTYTALTKQGYAIVGSHSGVKICRW
TKSALRGRGSCYKYSFYGINSHQCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVADPPD
MIFDGIRSGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLQLLHA
EHISSFLVCNAQHPDQLAALGHVTQLYVSIDASNKDSLRRIDRPLHRDFWERLQRCLDIL
REKRFRQRTVFRLTLVKGFNVEDEVEGYADMVEKAMPCFVEVKGVTYCGTSTSAGAGLSM
SNVPFYHEVTEFVTALEKSLRKRGLAYGLAAEHAHSCCVLLASERFLVDGKWHTRIDYEK
FFQLLEQKGPHGDFSPEDYMGPETPEWATWGNGGFDPRDQRVDRKGRPIEA
>A0A157SZY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharolobus solfataricus|TrEMBL
MCDRMYNMQSNLRIDTVSEIFKELQKEKYHIIGTHSAYKKCHWTHSALVANRSCYKGKFY
GIESHRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHRK
AVSGYLGRNDVSIQKVKDAMKPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGV
RPDILASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRF
TMIKGYNMSEQDAKEFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKI
LGQYTGYKILSEHVPSRIVLLSKLDKPIKIGNAWNEKWNWSTIDMEDDMSGEYKEAEQGC
TEGST
>A0A1V5AY26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaU1.Bin055|TrEMBL
MIERFPPTMAEMLKRQGYHLVAHGAVKPCLWLRRSIRGGDQCYKHHFYGIASHRCVQMTP
TLLCNHRCLHCWRPIDEIPTASGDWIEPPELLDGILSEQQRLISGYGGAPETTDLARLEE
ARRPAHVAISLMGEPTLYPMIGELVDEVKRRGMTAFLVTNGTIPEVVGEVRPTQLYISLN
APDEETYLRVSNPRANYWGRFLESLATMRDSPSRTVARLTLARNLNLKDPQGYAKLIEIA
EPDFVEVKAYMHLGLSRKRLERDSMPTHDEVMSFAGELSDILGYTLKNHVPLSRVALLSR
GSSPEKIEL
>A0A172WHA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus piezophilus|TrEMBL
MAIVVKSNPNMPEEIARLFKKQHYALVGNHSGVKLCHWLKESIKHDRFCYKQKFYGIHAH
RCLQMTPVLAWCTHNCIFCWRPMEGFLNVELPKPWDDPVFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMSPDGWEKILRTLELMNGLPTRTVIRLTLVKGE
NMHNPEGYAKFIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVRHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>F6ZQB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xenopus tropicalis|TrEMBL
MTQTLILGILPQAAFVAAQQVDTDMSTNAWDFAYTHLMFLWLNRFYIYSCAAIGITVWFC
SHFITARKKQQNENVHNGSLPLKTKTLKSYNSPSIKEQDVYVAGVKIFYGSQTGTAKGFA
HMLDGEITLLGLPVEIINMKEYDPDDNLIEEATSKNVCVFLVATYTDGQPPESAEWFCKW
LEEASNDFRFGKTYLKGMRYAVFGLGNSVYSTHYNTVGKNIDKWLWMLSASRVMTRAEGD
CNVVKSKHGSIESDFEAWKAKFLSRLKALISGEKKPCSGKCKKGKCKSKMKSSTDAVEEE
AKHSEHEETEEETFETTSDSEPEEHGEPGSGLIDMEDLGKAMSIMKKAKREQDTNEEARN
RGKSLQSDEAKEKEEPREMITPALQEALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILEEAILNHQNM
IKQFKGVPGVKPERYEEGLVVKHCALSLVGEPIMYPEINKFLRLLHNQHISSFLVTNAQF
PEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTL
VKAWNVEELKAYADLVAVGRPDFIEVKGVTYCGESSASNLTMANVPWHDEVVRFVEELAD
LLPDYEVACEHEHSNCMLIAHEKVLFY
>A0A7C9A8H1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Opuntia streptacantha|TrEMBL
MTAMASSTLYSRVTLLALLSATTFYCFYKSRRLKKLSSSASQRLVSSHRNPKLIYITQTG
TSKTLAYRLHKLFSSKDLVFDLVDVKDYEPEDLARESVVVIVTSTWEDGKPPPKAKFFAD
WIEESVNDFRVGALLLSRCKFAVFGVGSGAYGESFNAVAKGISKKLKALGAKEMVPLQEG
DVDGGELGHEIDAWGQKLITVLKGGALDNGVSVPRSVDGGSDSEGAYVSEDEEGQENGAE
LDVVDLEDIAGKGPSRKSRAEVEVNGVKSCSQREMVTPLIRANLEKQGYKIIGSHSGVKI
CRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMD
DATEIVNTAIELHTKMIKQMKGVPGVEEKRLSEGLLPRHCALSLVGEPIMYPEINSLVDE
LHRRRISTFLVTNAQFPEKIRMLKPITQLYVSVDAATKESLKAVDRPLFGDFWERFLDSL
KALREKQQRTVYRLTLVKGWNAEDVDGYFKLFSLGKPDFIEIKGVTYCGSSATSKLTMEN
VPWHADVKAFSEALALKSEGEYEVACEHEHSCCVLLAKVDKFKVNGQWFTWIDYEKFHDL
VASGKAFSSTDYMAPTPSWAVYGAAEGGFDPGQTRYRKERNHKSTRQCS
>F0VJ08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neospora caninum (strain Liverpool)|TrEMBL
MWTSGYLDPRLSSLLSKYGEKRSPSPFPAVHDAESTRAPSSSTNSGDAGSPLSPRTRESE
QGKKQTARPETGRHPPGRAPFRILILFGSSGGTSAAIAFSLFHSLRQQLSSGDGACTPRS
GSVSRGNHGREGSSQEREKNSQPITICRTGDGDSHPEKEERERSDAEPLRDAAVSSSSSA
SVFSLSKKKERKIATSASGGFSEGSRAAETALEKARNFMNEARNASPSSFDPSSRKLWFL
DRACAGGVELLVQSMEFFSFDDLVALLEESPSVHDASSNASSPQTRPSPGASAPCPCPAV
ASSSRSDASEASASSLSASSLSSPSSSSARLLLLFCLSTASQGTPPSAAAAFCADAEDAR
KDFRIGKNILSTCLVAGIGCGSTEYPASTFCRPAKHLFKTLTGHLEALPLLLLPCSSDVP
SPLSASSLASSASAPPRVSAATASSLLLLSDTHTDRSLETKVKKWETEAVRRLVDFLRAS
PNEREIWMSLAKDRKSRERKTLSGGSREAGTTARRGKETSTKVEINGDPQGERVTADEQS
AHGATGRDAKGESETEGEASSVDAFSSAVSSGEESDLDETSSIFSSEDDEAEGRTERLAT
SVSGTDTGGGPCGNAEGNHDLEDVVGAGEDNARSGDRRRQRERETQSLRSCVGGDGEAAG
EARRRRKTMLSEKQATQLKKEGYKLVGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSSQ
CMELTPSLACANKCVFCWRHHKNPVGTSWRWQMDSPDFVVEQGLKNHFAAVKELKGMAEV
NEARLASARAEVRHCALSLVGEPIMYPRIDELVKLLHQQHISTFLVTNAQFPDALRNLPP
VTQLYVSVDAANPKDLKALDQPLFADYWERFVACLELLKEKRQRTVYRLTLVAGYNMDNP
SGSTPDKPDTGENPETRSTPASPPESPQNEAKDRCCRAVASGDTETGHACGCRSPSMLDG
DRAREETRTRGLGRRGEKATQGRAESREGQSLTDRSAAAYAKLVLRGSPDLIEVKAVTYS
GTSKHSKLTMKNIPWHDQALCDALPAGQYAIACEHRHSCCVLIAKTSYRRDGVWHTWIDY
DRFHQLATSGNTAFTGFDYCAPTPSWAVYGSAEAGFSPFEKRVFSKGKQKRLLRDKDRSG
PDADAPNGGN
>A0A150JMF9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MEDVWSTLKRQKYKIVGAHSAVKICHWTKKSLIENRVCYKQKFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDTPYSYDVPEAIVEGCINAQRELLSGYHGFLEKVDINKLKEAEN
PTNVAISLAGEPTLYPDLSGLIEEFRKRKFSTFLVTNGTTPDVLSSMDSYPDNLYITLPA
PTKEXYEHICNPQIKDGWXKLNESLELXQXIKTKRRXLRLTLVKDFNMKXVEEYSKLIEK
TNPDXIEAKAYMFVGYSRKRLEVENMPMFDDVLEFCKELEXKTGYKSIDFAKDSRVILLS
RN
>A0A0P5AZY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daphnia magna|TrEMBL
MMKVVQPPLIGSFFLPSLGLAVLSLIVGYWVTRKKKDNIKSELDINESPSGLENELYSMP
ATENPKRKKKKHVCNCGSTQASNFEKHPSRIKIMYGTLMGKSKKFAEMLLGHVAEDGMEV
SAINLKECDSEDNFVGSDAKDTLFIFIVSTYAEGSPPDDAQWFYKWLEDSAFDFRVPKTL
LADVRFSVFGLGNSLYSENYNVIGRNIDNWLSQLGAERYAPLGLGDENVAESLHGNIEAD
FDHWSEGILNLLKQPQHTTVNKSGCSKGNDCCSKKGKKKITNKFQKKKNNILEEADVTYD
TDSDSDSNEPVLDLEDLGSFVRVENKAVEDSEEEEEINVENGETREMLTPQLRESLTKQG
YRLIGTHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHS
NPVGTEWRWKMDPAELILEGALEQHTKMINQFKGVPGVQPNRLVEGMSPVHCALSLVGEP
IMYPEINRFLRMLHEKKISSFLVTNAQFPEAIRQLEPCTQLYVSVDASTKDSLKRIDRPL
FKDFWERFLDSLRALSAKGQRTVYRLTLVKAWNVEELESYANLVKLGEPDFIEIKGVTFC
GTSKASTLTMENIPWHHEVVTFGEKICTYLEGYGLAAEHEHSNCILLAKRSKFFRDGRWN
TWIDYDKFHQLMLEYYLSGGTHETFHG
>A0A8D0ZTX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYNRFQELIQEYEDSGGSKTFS
>A0A0N0BQ22|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula rubripromontorii|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFEQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMSEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWERDALVEY
>T1FQV4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Helobdella robusta|TrEMBL
MIEKLFETIGLSGLFYFVAGLLLGYVFFYRSTPNKQQDNDDRSHSKHSSNKNKKSQCNRF
KILKIYFATQSGKSEKLAKKLSDAAKERGLDVRLISLSNYDPDGKIQKNLSKDTLCIFIA
PTHTWGQPPEDSRWFFQYVHDASGDFRVSKKLLSNMSYAVVSLGNSEYAEHFCTVGKELD
KDLLHLGARRVLKNFIIDDHLHNGDKRFDIWMNSLWSLIAINAASKNLHHGDNKVMYGDC
GVVNNNGDGNDVISNNNHVCCNSSAGDHACYRKIRSEIKDEEKYNEKGHGDNSGEIRNNH
NGVIDNHNVDDDKDYNIIDGDEDYYDEDDDDEDEQADDGDDNVLDVEDLAGVIDAAATGK
AKRSVGPIDMITPVIRHSLEKQGYKLIGGHSGVKLCRWTKSMLRGRGGCYKHTFYGIESH
RCMETTPSLACANKCVFCWRHHTNPVGTEWRWKVDDPQMILDGAIENHCNLIKQFKGVPG
VEVDRLLEGMTPVHCALSLVGEPIMYPHINQFVHLLHQRKISSFLVTNAQFPEAIKNLIP
VTQLYVSIDAGTKEQLKKIDRPLFKDYWERYISCLSELKNKKQRTVYRLTLVKGYNTSDI
EEYARLVQYGCPEFIEVKGVTYCGDSKSSHGMTMKNVPWLEEVVDFVQKLVSLLPDYEIA
SEHAHSLCLLVGHKKFKRDDRWHTWIDYEKFHELNASFQQDASKTFTSMDYMAPTPTWAC
YGAPERGFDPAHVRFRRKNKDAV
>A0A7C4HJ54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MTSLENTLESFKRNLLKQGYRIVGSHSGVKICEWTKKSLTQGRYCYKQKWYGIESHRCLQ
CSLALFWCLNRCLYCWRSFKIFLGAEMDVKPDEPEWLLNGLVEAQRILLTGYKGNIKVER
RKWEEAQNPTNIAISLIGESVLYPYLSEFIEVARKRGMKTFLVTKGTYPEGLEKLWVEPT
NLYISVCAPDEETFNRLEAPIKQNGWEAQMKSLELMRSFNCRKVVRITLVKGYNMHNVDG
YAKLIERAEPDYIEPKAYMRVGESIKRLPETAMPSCEDVLEFAEKLADKTGYAIKDFFRS
SRVALLSKKN
>A0A072VEV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Medicago truncatula|TrEMBL
MPFSSVPARLTLLALFSATTFYFFYKSRRLRNLKQLTLNSQNPNTNPKILFISQTNTSKT
LANHLHRFLTSNNLAFDIIDGRNYEPEDLPKETLLLIVASTWEDGKPPPEYKFFADWLAE
SSEDFRVGSLILSKCRFAVFGVGSGGYGDNFNAVGKEIVKRMKALGGNEMIPLGEGDVNG
GEVDEVFEKWCGKVVGMLKGVDDGGGDLENGEEESGALSSDEEESDEEEEAESEIVDLED
IAGKAPSRKLVATVKESNGRLNGKKEMVTPVIRANLVKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWVWEMDDPIEIVNS
AIDQHTNMIKQMKGVPGRTVAIFNGCQTRISNNRYVGNAQNYLTRVWSKRRNRELSWLKK
ARQTAIPTTSMFFISNLKWGTQRRLRCTDTAIIDTASASMSNSNESTEIVAVREKLMHDL
KIPADRMEDTILREEREEYTKSLLSRRIRE
>U3FE10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callithrix jacchus|TrEMBL
MDPSVDTWDLSSPLLSLWINRFYIYLGFAFSISLWICVQMVIKKQDRNIQENSFPKTTQD
LMRNGYVSLQKKDIFVPGVKIFYGSQTGTAKGFATVLAEAVVSLDLPVAIINLKEYDPDD
CLIEEVTGKHVCVFLVATYTDGRPTESAEWFCSWLEDASRDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVSRGEGDCDVVKSKHGSIEADFRAWKATFISQL
QALQKGERKKSCGGHCKKGKCKSQQHGSEEREEGSLEQDELHHRDTEEEEPSEDSSEEEF
GGEDQQSVNSIVDVEDLGKIMDHMKKEKREKEQQEAKTSLLVNMGRNEDGEGRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTAWRWKLDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMAVKHC
ALSLVGEPIMYPEINSFLKLLHQRRISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGSEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A8C0Q8T5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus familiaris|TrEMBL
MDPFSDTWDFSSPVISLWINRFYIYLGFAFGISLWICFQIVIRKQLFILKGKKSQEKSVP
KATGDLMTNGCISLQNKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKE
YDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FLARLQALQKGEKKPCDGNCKRGQCESSVEEEPSESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSERRTMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKIGREWWTWIDYNRFQEL
VQGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A1L9C1R1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus portucalensis FDF-1|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPAPSKWDSPVEIVGSSIEGQRNLISGFGGSASRELWQQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIEPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPGHEEVLDFANQLGCELGYEVADQVEISRVVMLCRD
GKFIASKLPV
>A0A126R0E1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter olleyae|TrEMBL
MTFTKEEQEKLEYSGYRFVGEYGHAAAKICHWTKKSMVNEGVCYKEQFYGVKSHRCLQMS
PAVPFCSQKCSFCWRDLSQTRVEWEGEYDNPKTIIEGAIKAQNNLLCGFGGNKKTDEKKL
EESKKPTNAAISLAGEPTLYPEIDELLAEFKRQNFTTFLVSNGMYWEKLGSLECEPSQLY
ISLDAPNEKVYKDLCNPQINNAWSNLNKTLELMNSFDTNTAIRITSVKGKNMINTKEYGE
LINKANPKYVEVKAYMFVGSSRKRLSLDNMPSFKEVCDFAEKIADETSREITKHSEISRV
VLLE
>M8AXY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aegilops tauschii|TrEMBL
MTVVRGPPGRPSALVSWWSRRPPLGFAAKKRRAPPRSRRPNATPSPDAAALRSNLTDPDA
RPEPEQPNKPEPEWEWEDEQEPELSVPEDDGDATGKAPKEEENDDKAPALEWADESSELD
AEEEEDPEAAKGKASKKKKKKKLPPLFSPAAHYHWKLCSAKSGHHYTPCVDFDGDGSQKH
HERSCPRSPVTCLVSLPKEYKLPAPWPERKEKIWYGNVGHPRLSSYAKDHSWLNRTGEHL
VFPPEESEFKGGARHYIDTIDEVTIGGSFTFAVDASFPDFWKVIPRWLSSTVKSFTTLSA
LMAPDLDWGKNIRIALDIGCKSAGFGVALLEKDVITLSLGLTNDQTDLAQVALERGIPAT
IGSLGSRRLPFPSGSFDIIHCSECNIPWHSNGGKLLIEMNRILRPGGYFIISSRHGDLES
EEGISASMASVCWNVIAYNSDDVSELGVKIFQRPASNDEYDLRAKKDPPFCKEEQNKATA
WYTPIKHCLHKAPAGIEERGSEWPEEWPKRLETFPDWLGDLQTRVSADHSHWKAVVEKSY
LDGLGINWTNIRNVLDMKAVYGGFAAALSSEKVWVMNVVPVHAPDTLPVIFERGLVGVYH
DWCEPFSTYPRSYDLLHADHLFSRLKNRCKEPVAILVEMDRILRPGGWAIIREKLEILDP
LEAILKSLHWEIVMTFRKDKEVLILPGWLLIWDEGTYTPAADFRAGALLLSGLRFAVFGV
GSRAYGDTFNAAARSFSRWLRALGAVEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEE
VEEDGVDGETNGFDGLEGEESDYDDDDDEEEEEEVASAEVDMEDIAGKATAKKQNGKVES
ALPNGGQNGARAMVTPIIRASLEKQISVVLACKGYKIVGSHSGVKICRWTKSQLRGRGGC
YKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDDPLDIVNTAIDEHR
KMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINTLVDDLHRRHISTFLVTNA
QFPEKIKALKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSLHDKDQRTVYRL
TLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTYCGSSATSKLTMENVPWHADVKEFSEVL
ASKSGGVYELACEHVHSCCVLLAKVDKFKINGKWHTWIDYDRFNELVTSGKPFKSSDYMA
VTPSWAVYGADEGGFDPDQARFKKERRHGAAALKG
>A0A815D4C3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria magnacalcarata|TrEMBL
MAVDIDILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSSTS
QPSTKNNSDEKNGITIVFGSLKGNSRTFAKLTSEKLSNELNRHVILQDLKDITDPEEFLQ
IQAKEQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAIFGCGNSL
YTENFNKVATEIDRCLSELGATTLLATELADENTGKSIYGGLEGHYSKWSSKLVSALESK
ATGKCGCRANEDSVTCCKSPSTNSHSKETNGTNEVLIESDDDDEGGNKDGEEDVMDLEDM
GDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIDNHYKM
INTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQF
PDEIRVLQPVTQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKTKGQRTVYRLTL
VKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVVTFVRLLCE
RLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGAETFTSLDY
MAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>A0A3L6SBC7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panicum miliaceum|TrEMBL
MPPFPTATTASATSHLALLFLLSSSSLFFFYKSIRLRRKPSPATATGPARTTIPTLLYAS
ATGTSKTLAARLSARLTADVGVPVSATDATSFEPDDLPSVPLLLLLVPTHDGGAPPPSAA
FLARWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAVEVVP
LGEGDVDGGDLEAVFEEWSGTVLRVVKGEELNEGVEGESDGLDELELEGEESDVDDEEEA
VSGEIDMEDIAGKAPARMQNGKVEGGLTNGGQNGVKEMVTPIIRTSLEKQGYKILGSHSG
VKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKW
KMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINAL
VDELHRRHISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFL
DSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGQPDFIEIKGVTYCGSSATSKLT
MENVPWHSDVKEFSEVDKFKINGKWHTWIDYDRFHELVISGKPFKSQDYMAVTPSWAVYG
AEEGGFDPDQSRFKKERRHGTAVLKG
>A0A8J8J3I4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. GR7|TrEMBL
MAITFKSNPNMPGEIARLFKKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPGPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTAPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKITRTLELMNGLPTRTVIRLTLVKDE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A1C8ZVY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. A20|TrEMBL
MQSNIRIDTLSEIYKELKKEKYHIVGTHSAYKKCHWTHESLVTNRSCYKGKFYGIESHRC
VQMTPTAAWCWFRCIHCWRLEPEDIGLEWDDTKMPAYDDPEYIVERSIEEHKRAVSGYFG
REGVKLEKVKDAMKPAHVAISLTGEPTLYEKLGELIREYHKRGLTTFLVTSGIRPDILAS
LEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLLMKTLEILPSFSSPTVIRLTMIKGYN
MSDEDAKEFAKLFQIAMPTYIEVKAYMHVGPSTYRLSKDAMPRHNEIREFAKLLSNYTGY
KILSEHVPSRIVLLSKLDEPIKIGNAWNERWDWRTVDIEDDINGEYKEAELGCTEGST
>A0A671Q4W2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
IKTIHFLSGTNFCSACVIVIIIYLSNLKNYMQLCCDVFVNYYFNSGIQCEVIDMKEYDPE
DRLAEECTSKMICVFLVATYTDGQPTESAEWFCKWLEEASMDFRYGKTFLKGMRYAVFGL
GNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWETKFLKR
LQALAKGEKKACSGKCKSGSCKNKKKHKEEAEDSQSHTEKNNSEASQPSSLMSLNTCSHG
NSSRSAHPESRLFPCSLLRKSESEEERREMITPALRDALTKQGYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHNTNPVGTEWRWKMDPAEKI
IQEALENHRNMIRQFRGVPGVHPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQN
ISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGE
KQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHE
EVVYFVQQLANLLPDYEIACEHEHSNCLSLAHHKFKVDGEWWTWIDYERFQELIQEYEES
GGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A497IV03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MQRKSVNAGLSPDIIATLKRQGYHLVGKHSAVKPCLWLKKSLRGEGLCYKGLFYGIKSHC
CVQMTPSIFCNQRCLHCWRPIEILNFEDVTDVEWDTPASIVDGCLREQQRLISGYKGAKT
TDLKALDEARAPKHAAISLIGEPTLYPHLKELVEEFHKRGMTTFVVTNGTKPEVLRRITP
TQLYLSLNATHEGLYRKISGADFWEEIKESLRVLRRKDEEGVRTVIRITCVEGLNMDDAE
GYASLVKLAAPAFVEVKAYMYLGFSRLRLHRDAMPSHESVRRFAAEIAEAAGYKVAKESE
TSRVVLLARALGG
>A0A7J4FYI0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MRTRPKSGDPSERDGYPIAGRHSAVKPCLWLNRAMRGEGSCYKSQFYGIQSHRCIQMTPT
LSCNHRCLHCWRQIERSVPLPAPTDWDSPVEIKGSIIAEHLRLISGYGGSDTTDPDALKE
AQLPDQVAISLAGEPTLYPHLPELIEEFGRDGMTTFLVTNGTQPEMITKIFPTQLYISLN
APDEATYLRVCNPIGNFWSEIQESLEILGTARSRMRTAVRITLIRGLNIFDPEGYAHLLQ
TCEPDHIEIKAYMHLGFSRKRLKRDAMPGHDEVLLFASKIADEIGYQVADDAELSRVLLL
SRDGRARRVR
>A0A1E4RQ14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hyphopichia burtonii NRRL Y-1933|TrEMBL
MASGLYLLVLCIAVYLVSGGRLSIALAGAAAYYLHQHSVESKKTSQINEARETKESPIYA
VDFTSTTFTPNETSNIPANPTPTKSKTISSLRSRAKRTPKVFKASKPVKKTSTEPVLTKT
TVDLLESQIYIFYTSLTGTSQRIAKSLNEKLNNLYNLKNPPKLLSLDDDVDDLEEYFLKT
PKQNGDTKNIYVMVLPSYEIDSPIDYFLDHLTETYNDFRVDKYPLKSLLGFAVLGLGDSE
SWPEKFCYQARLADKWLGKLGGRRLYPLGEVCMKYEGEPVANEWIQNFAGLLNDNEPFYL
DDDDFEDSDKEEEESDSTDGDGETLVDVEDMGDIMKKQGTDGLKSEAKEMVSKNSPTYKS
LTKQGYSIIGSHSGVKICRWTKSALRGRGSCYKFAFYGIRSHLCMEFTPSLACSNKCVFC
WRHGTNPVAKLTWRWKLDPPDVIVQGALQAHYQKIKQMRGVPGIQMDRFEEAFKVKHAAL
SLVGEPISYLEISSLIKNELHSRGISSFLVCNAQHPDNLRSLCKVTQLYVSIDAPTKTDL
KKIDRPLNSDFWERLMECLDILRTVQSHQRTVFRLTLVKGFNMDEIKGYADMVIRAQPSQ
IEVKGATFCGSSTGNGNPLTMQNIPFYEECRKFVINLSEELKSRGYDYEVAAEHAHSCCI
LIAHTKFKINNKWHTHIDYPRFFELVESGEEFTDMDYIKETPEWAVWGSKEAGFNPLDVK
FDRKAEKLKKKKEREEQARIALEKQPITQES
>A0A075GU40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_201_G04|TrEMBL
MIFSMSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYK
HKFYGISTHSCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEEIMTKLMAERK
KLIMGHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVT
NGQEPDMIRKLEDEDALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLGT
RTVLRITLIRGYNDDEEMIPAFASLLRQSNVHFVEIKSYMHIGRSTNRLEHSDMLEMDEV
RSFADKLVQENNAFTVMDESEISRIVILQNKKRFIDRFIPAYC
>C7Z4G3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4)|TrEMBL
MDWANYSSPSRLDSFVEDLVDVWHIHRTPILVAALVVLGTLRIYLTFIGRKTELVALTEA
YKEPPKPKAVVEAKTPAVETIDEKKDVKPQGPRRIKGGVARKPSKKNEQEKDLTRPIMVL
VFFSSITTKTDKIAQAYLKELEAKQEEIAKQSGRQFLKPELKDLTEIDFDDFFIAPPKMH
GDVDYFYTFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDKENWPT
EGEGFCFQAKEVDKWMAKLTSRKRAYPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDAAEDEDDGEVLFEDDDTSDAKKNGRPLDDVEDLGRMIRKDDG
SMVQKAPLAVDFTTYSSTKKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRWT
KSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDL
IFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHAE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLDILR
EKRFRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALEKRLKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKKF
FDLLEERGPEGDWTPEDYMDPEPNPDWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A2T4AVA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma harzianum CBS 226.95|TrEMBL
MDAGSRLQLEAMVADLVEVWHIHRTTIILASLFLLAGLRIFLHTTEKREPLAALPKIYNQ
EQPKASEKPIVKAQPAVDTEKKSTGPRRIKGGLTRKSSQEGKPATNESTDRPAKVLVFFS
SVTTKTEKIARDYINALETFVDQKAKETDGKFLKPELLDLTEIDFEDYFVSPPKSAEGVA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHAERFAEWTSGVQDVIAQAAQTGFLGEG
VPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDVEDLGKMIRTKDGNEGT
RKAPLAVDFTTYTSANKKKAQAPIIKEMVAKDSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLAEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQKFF
ELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>A0A0D3FPN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza barthii|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPPAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGHNGESDGFDELEEEESDDDDDEEEV
DGGEVDMEDIAGKAPAARRRNGKVEGALSNGGENGVRDMVTPIIRTSLEKQGYKIIGSHS
GVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWK
WKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINV
LIDELHRRHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERF
LDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKL
TMENVPWHSDVKDFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDR
FHELVTSGKPFRSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A7C2RVI3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MIRLQIIRDPYKEINDKLRAQKYHLIGSHSAVKKCLWTHKAIYEGKFCYKGKFYGIESHR
CIQSSVSTQWCWNACMHCWRFRPTDMIDEWDEKALISIDDPRFIVEMSILEHRRTVSGYK
AHGVPEDIIMEAMTPKHVAISLTGENSLYPRLGELIREYHRRGITTFLVTRAVRPDIIAN
LDEEPSQLYISLETYDEESYEFFTAPLVANAWRLTMETIEILPSFTCPTVYRITAVRGWN
MDEKAVKGFARLVEIGMPTFIEIKAYMHVGTSITRLTRDNMPTYDEVLGFAERLARETGY
KLVSQSRPSRVALLSLLDKPLIRHGDAKISWWDPDYEGEDEYEQQSVYGSIITK
>A0A328SI90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. rholeuAM270|TrEMBL
MIITDNERKNLEKKGYRFAGQYAHAANKICHWTRKSIVDDGVCYKEQFYGIKSHRCLQMS
PSVPYCQHKCLFCWRDTDITKTSWDSDDYDDPGTIIEDCVENQKRLLCGYFGNDNANPKK
LEECVKPNNAAMSLAGEPLLYPEINQLIHEFKRRDFTTFLVSNGEYPEGIRRLEEEEPTQ
LYLSLDAPDVETYRRVCLPQVDNGWEKLNESLELLSTLDTRKVLRITSVKDLNMNNPEEY
ARIISGCDVDYVEIKAYMFVGDSRNRLEWENMPKSVDIREFAKEVAMHSGLEVIDEVEKS
RVLLLGEKKPKKYNN
>A0A6G3LS41|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobus sp|TrEMBL
MEVRAEEDVYRLLDQRLIKQGYHLVGRHSSVKKCYWNHAALVEGRFCYKGKFYGIESHRC
IQLSVTNHWCWNACLHCWRLRPQDVGIQWNETRMPFADDPRSIVEGAIREYRRIVSGYKG
RPGVDPKMYQEATNPKHVAISLTGEATLYPMLGELIKEFHRRGITTFLVTRGVRPDVLAN
LEEEPTQIYVSLEAWDKESYDYFNRPLVPRAWELTLETLQMLPSFSSTTVYRITIVKGFN
DNDAALRGFAELVKLGMPDYVEVKAYMYVGASRNRLRLENMPRHEEVKAIARKLSELTGY
PVVSESAPSRVVLLSRLERPIRYGNAPVDWNSPDIPAPGEYEEPNEAATA
>A0A6V8ELU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPKIAARLAKQSYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDKLTKIDDDPYELFLESVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDVCHQHGVSTFLVTNGSLPKVIEELDPLPTQLYVSVDAP
NKEIFNRLCKPKFDTAAFEKLEKTLALLPSLDTRTVCRHTLIKGESLGHWKDYARLDNIA
DPDFIEAKGYVYVGNSRANHTIENMPSHDDVMDFSRKLAPLVGREVLSERRESRVALIGR
EMIPIVLPEKVRELPKDLGIAKPQNFSLPIA
>A0A6V8CW49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPTIRAKLAKQSYHLVGEHGGVKVCHWTKESLKNDRACYKGTFYGIESSGCMQMAPNVD
TCNLACTYCWREPHSETLNKVDSDPEMLFYESVRAHRRLLTGFKGHPSVPLEKWQEAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NQEIFNRICKPKFDSHAWDKLEQTLELLPSLDTRTVCRHTLIKGESLGHHEDYARLDNIA
DPMFIEAKGYVYVGNSRNNLSIENMPSHDDVMSFSNSLAPLVGREVLSDRRESRVALIGK
EMIPVTLPEKTRDLPANLGIAKPQNFKLPSL
>A0A8C6AWE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monodon monoceros|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINKFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A8J8Y5M8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callithrix jacchus|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAFSISLWICVQIVIKKQDRNIQENSFPKTTQD
LMRNGYVSLQKKDIFVPGVKIFYGSQTGTAKGFATVLAEAVVSLDLPVAIINLKEYDPDD
CLIEEVTGKHVCVFLVATYTDGRPTESAEWFCSWLEDASRDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVSRGEGDCDVVKSKHGSIEADFRAWKAMFISQL
QALQKGERKKSCGGHCKKGKCKSQQHGSEEREEGSLEQDELHHRDTEEEEPSEGSSGEEF
GGEDQQSVNSIVDVEDLGKIMDHMKKEKREKEQQEAKTSLLVNMGRNEDGEGRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTAWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMAVKHC
ALSLVGEPIMYPEINSFLKLLHQRRISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGSEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A6P8BKC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Magnaporthe grisea|TrEMBL
MSHPLGTTSSLGDLPSLAVEIWHSYRIQIILSIFTTLILLRFYLEHTQGRDQSSVAFAKK
FGEQTVKEEPTPTPVETPKTSTTLGKTKPSGPRRIKGDVNKTGRNGTAQADITATGREIL
PLVFFSSVTGRTDKVAREYAARLDESLGGLPAVVGCSFRESRILDLSEIDYDEYFISVPN
IEAQKEGSRVELLYLLLLPSFNIDTINDTFLEHLQETHHDFRIDTAPLAPILGYSVFGFG
DREGWPTEEEGFCFQAKEVDKWMAKLTGRKRACPLGMGDSKTDASERLSEWHDGVVDVLS
LLAQTGSLGEGVRGSGDAVESEDEGGSDEEDDEVLIEDNESMEKKPKKSKSKALDDVEDI
GRMLDTSRANGTAPPVAVDFTTYDKPKGGSKKQPAIQTVKEMVPKSSPTYAALTKQGYAI
VGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMEATPSLSCSNKCVFCWRHGTNPV
GTTWRWVADPPDMIFDGIRAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINEFLRLLHAEHISSFLVCNAQHPDQLAALGHVTQLYVSIDASNKDSLRRIDRPLHRD
FWERLQRCLDILREKRFRQRTVFRLTLVKGFNVEDEVEGYADMVEKAMPCFVEVKGVTYC
GTSTSAGAGLSMSNVPFYHEVTEFVTALEKSLRKRGLAYGLAAEHAHSCCVLLASERFLV
DGKWHTRIDYEKFFQLLEEKGPHGDFSPEDYMGPETPEWATWGNGGFDPRDQRVDRKGRP
IEA
>K0KX33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Wickerhamomyces ciferrii (strain ATCC 14091 / BCRC 22168 / CBS 111 / JCM 3599 / NBRC 0793 / NRRL Y-1031 F-60-10)|TrEMBL
MSSKIPTSLVVSGAIITYLLSGGRFTIALFAATVYALFIRKVSQDHQQDSISSNGQNHEH
KHKHKKEGGCGSACTCKDKKKENKKTLSGLKKLKGFGKKSEPQDDGIAVDFTTAFAKKPT
TTTTDKSTGRPANGKPRVKRVPKLIKSKGLQSKQKEPPKQMTKANTSLLDSNIIIFYTSL
TGASERSAKNLYETMSSLNLMGSLKNKPQLMNLDDITDLDDYFMNVPKLDNLIYCLVLPS
YDVDSPIDYFLQTLEDTYQDFRVDKYPLKKLLGFTVLGLGDLESWPEKFCYQAKKTDYWL
GKLGARRIFPVGEMCIKTQGDEKIKEWINLFVDALKDDEPILYEYRDSDAEDSDAEDGDA
NSSSGESEDTLVDVEDMGNMMKSSEKEKISNSSSSEVKEMVAKNSPTFKSLTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKFAFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGT
NWRWQVDQPDVILEGALQGHYSKIKQMRGVPGVVADRFTEAFRVRHCALSLVGEPIFYPY
INDFVGMLHEREISSFLVCNAQHPDQLEALHKVTQLYVSIDAPTKNELKKVDRPLFKDYW
ERLIKCLDILRTSQAHQRTVFRLTLVKGFNMSEAEAYADLVERARPSLIEIKGATFCGSS
SGNGNPLTMQNIPFYEECQNFVKNLTNELNKRGLGYGIAAEHAHSCCILVGSNQFNINGE
WHTHIDYSKFFELLKNGQPFDKLDYIAKTPDWALWGSDSAGFNPEDTRVRKKGKNKEKKA
PVIEEVTV
>A0A6J0UK23|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pogona vitticeps|TrEMBL
MSLEEPWSGLHAHLTFLWLNRFYLYSCAALGISLWICLQLLLKSKKQDGNHLRKESLPEV
TDDQQGQKEPQVLNKVHVSGVKIFYGSQTGTAKRFAFILTEAISSTNLPAEVVDMRDYDP
DDSLIDEASSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKTYLKGLRYAVFG
LGNSLYADHYNIVSRNVDKWLWMLGAQRVLSCARGDANVARSKHGSLEADFEAWKGQFLA
RLRALCAGERKACSGKCKKGRCRSQRKASRAVSEQDPGTSEHEEKEEEELFETTSEEESG
SDEGDSHQVIDVEDLGKVMRQMKKAQKEQDLDNEAAGLAGSPWSGREEERREMITPALRE
ALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPPENILQEALENHQNLIKQFKGVPGVRADRLEEGMEAKHCAL
SLVGEPIMYPQINQFLRLLHRRNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLK
RIDRPIFRDFWQRFLDSLRALSEKQQRTVYRLTLVKAWNVDELKGYSDLVSLGKPDFIEV
KGVTYCGESSASNLTLANVPWHEEVTHFVRELVALLPDYEIACEHEHSNCLLIAHKKFKI
HGVWHTWIDYARFQDLARRYEESGGAQKFTAADYVAPTPPWAVFGAEERGFDPTDTRFQR
KNRTKDISGC
>A0A6J0UNA1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pogona vitticeps|TrEMBL
MEMSLEEPWSGLHAHLTFLWLNRFYLYSCAALGISLWICLQLLLKSKKQDGNHLRKESLP
EVTDDQQGQKEPQVLNKVHVSGVKIFYGSQTGTAKRFAFILTEAISSTNLPAEVVDMRDY
DPDDSLIDEASSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKTYLKGLRYAV
FGLGNSLYADHYNIVSRNVDKWLWMLGAQRVLSCARGDANVARSKHGSLEADFEAWKGQF
LARLRALCAGERKACSGKCKKGRCRSQRKASRAVSEQDPGTSEHEEKEEEELFETTSEEE
SGSDEGDSHQVIDVEDLGKVMRQMKKAQKEQDLDNEAAGLAGSPWSGREEERREMITPAL
REALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDPPENILQEALENHQNLIKQFKGVPGVRADRLEEGMEAKHC
ALSLVGEPIMYPQINQFLRLLHRRNISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDS
LKRIDRPIFRDFWQRFLDSLRALSEKQQRTVYRLTLVKAWNVDELKGYSDLVSLGKPDFI
EVKGVTYCGESSASNLTLANVPWHEEVTHFVRELVALLPDYEIACEHEHSNCLLIAHKKF
KIHGVWHTWIDYARFQDLARRYEESGGAQKFTAADYVAPTPPWAVFGAEERGFDPTDTRF
QRKNRTKDISGC
>A0A3L6NKJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. cepae|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLQEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8C5DVG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
MVVLCVFVANFVCFLSFCVFFLLFYCRFVFYFLSFTIFFYQFVFFLSHLVNFHGRFVFLL
SALCDFVLNFVCNELFLYFFYCRFVYFFFCHLVNLSPNLCFCCHLCVLGVILYILVHLCG
FFEGFCEFPLSCDVCVISRCVQGFAAELSEEVKTLGIPSEVIDMKDYDPDDQLADECTSR
TVCVFIVATYTDGRPTENAQWFCKWLEEASTDFRYGKTYLKGLRYAVLGLGNSAYVGHYN
TVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQDDFLAWKAHFLRRLQALARGDSG
SRSSKSSCMKTDGADHEGEEPTLTNHSSEEELMETSSDEEQSDERTSGSVVDVEDLGNLM
DSVKKSKVPETHVSVIVNMYSRVKSLFAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTF
YGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWLWKMDPAEKILEEAMEKHQNMIRQ
FKGVPGVLPERYQEGLAIKHCALSLVGEPIMYPEINTFLRLLHSQRISSFLVTNAQFPQE
IRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKA
WNVEEMQSYSELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVRQLADMLP
QYEIACEHEHSNCLLIAHTKFKVDGEWRTWIDYERFQELVEAHEASGGTRSFSALDYMSQ
TPHWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A850M3N4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Helarchaeota archaeon|TrEMBL
MKIMKALLPEEFLGKLKKQKYQVVRRHSGVKACRWTRKALTGSGVCYKQKFYGIKSHRCL
QMTPTMGFCTNHCLHCWRVEPDDINIQWDELLLEKLEDPDPPADIVDGCLEAQKRILSGY
KPTGHSKVSWDKWNEAMEPNQVAISLSGEPTLYPYINELIEEFKARRMSTFLVSNGTRPK
VIENLSKPTMFYISLYGPDKSTYLRVARPIEPNNWEKLNESLELMNSFNSNTVLRLTLIN
QVNLLQPEGYAKLIEKANPTFVEAKAYMYVGYSRSRLNFEHMPEFSQIQDFAKQLSAHTG
YDILDVSRPSRVVLLSRLKQKINVSKN
>A0A6A6VK45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sporormia fimetaria CBS 119925|TrEMBL
MDNFTTQRTTMASLTSLEQLPAELLLIWHTHRISLLVSAVALVAAFHLVRLLRTRRAVVE
TPTPIEKEVIELKPEWLPENTTFLAPAVATEAVARPQKTRKAPKTVRGQKASSKTPLSGP
IFNHETDNIQPLVFFQSLSGTTERYAAQVAKALSEWRSQNGDNSSILEPQLHDLSYIEFD
DFFITPPKAEPNTRHFYLILLPSYNIDTVLQNFLDNLQETHNDFRIDSASLNALLGYSVF
GLGDKEGWPTEEDGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGDLEVRLEEWRTGVQE
ALTEIAAGRGLGEGVPGSGDPVESDEEDVDDAEDSDTDSSIQKTSKPKRSARVDDVEDLG
GMVKDTADDATEIDFTTYKVKKKTKPTPVVKEMVPTTSPTYAALTKQGYSIIGSHSGVKI
CRWTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTD
APDVIFDGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLTI
MHRSRISTFLVCNAQHPAQLAALVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFTTCL
DILRARRFEQRTVFRLTLVKGFNMAEEVRGYADLIERALPGFVEVKGVTYCGTSAAGTAG
LTMQNVPFYEEVSAFVEALAQELEERKLPYGIAAEHAHSCCVLLADRTRFQRNGRWATRI
DYEKFFDLFEGKAQGTRIENVAGKEEVVGWRPEDYVGDETPEWALWGNGGFDPRDVRVYR
KGKGPKKVEEKGEAKVSVVEI
>A0A128A100|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotalea devanaterra|TrEMBL
MSCSGETVEVENEFIQIKPMILNQLKKAKYGISDHATVELCHWTKKSFKDDGQCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSALKMPTDKVAPPEVIMSNLMAERRKLIM
GHYGDPKSNKEKLDESLLPSHYAISLSGEPTMYPQLPDLIKYLRNLENTKSIFLVTNGQE
PEMLQRLSDEDALPTQLYLSTNAPDSEIFTLVNRPKYKDAWERWNTSLELLSKLNTRTVL
RFTLIKDYNADEKLIPKYAEMIKRANAHFIEIKSYMHVGRSTNRLEYSNSLDMLEIRQFA
DQLAKQSGMYSTMDESDMSRIVVLQNQQRFIDRWISSYSDTN
>A0A7C2V8W8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MCWRDWGGWILVASGAATLDVLDILNKQKYHIIGEHSAVKKCYWVHKSLTEKMFCYKAKF
YGIESHRCIQFSPSILWCWNLCLHCWRYRPSGWSNFPGHVDDPAYIAEMAIKEHRRTVSG
YKKYPNVDTKMFEEALNPKHVAISLTGEATLYPRLGELIEEFHRRDLTTFLVTRGVRPEV
LANLSEEPTQIYISIEAYDEDSYKRFNNPVKPGLWKKTLDTLELLPSFTSPTVIRITLVK
SFNMHRRAIEGWVRLLRIAEPTFIEVKAYMHIGSSILRLDRHDMPHHDEVKRIAEELARE
LGYNIVSESVPSRVVLLSKLSNPVIRYGNPPNSWYDKDFGDEYSGEYGALQEELI
>A0A429GA29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeum cryptofilum|TrEMBL
MLALGVSTPSHVRKLMEKQGYKFILNHSAVKPCYWFRKSIMEGKTCYKNKFFGIPTWRCI
QMTPTASFCNMQCVYCWRLNASDVPMSQRWVEVPEGKWDDPEEISEESVRVHRMLVQGYK
GVRVFNKDWVREAEEPKHAAISLTGEPTLYPFIGGLVEAFSKRGMTTFIVTNGTMPERIE
GLEREPTQLYVTVPAPNEKLYAEITRPIWPDAWSRLIRTLELLQSLSCPTVIRIPLMKGL
NMDERTLEEFSELIKRYQPTYVEPKAYEWVGYSRRRLNKWNMPWHHEVREFAYRLSDLTG
YRILDESEESGIVLLSRLERAIRFY
>A0A1W6K232|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus manzaensis|TrEMBL
MVVSSFRIDTLSKIMQEMEKQKYHIVGSHSAYKKCHWTHEALTEGRYCYKGKFYGIESHR
CVQMTPTAAWCWFRCIHCWRLEPEDIGMEWDETKLPITDDPEYIAEKSIEEHRKAVSGYF
GRQGVDPNMAKEASNPAHVAISLTGEPTLYERLGELIKEYHKRGLTTFLVTSGIRPDVLA
SLEEEPTQLFVSLQAPNEKKHKLINRPIIANSWNLFMKTLEILPSFSSPTVIRMTMIKGF
NMSEEDAKEFAQLLKIAMPTYIEIKSYMHVGPSTLRLSKDAMPRHNEIREFAKLMEKYTG
YKIISEHVPSRIVLLSKLEKPIQIGNAWTTKWNWSSKDIEDDINGEYREAELGCTEE
>A0A843ETL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp|TrEMBL
MSFNKNQIEKLEKSGYRFVGTHGHAAVKTCHWTRHSIVDKGVCYKEKFYGIKSHRCLQMS
PAVPNCQQECEFCWRDLTYTQTTWEDEEYDDPKTIIDEAIKAQNNLLCGYYGNDKANKQK
LEEMKNPTNAAISLAGEPTLYPKIDELIGEFNRRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPSKKIFNEVCRPRIDDAWSNLNESLETLSSFNSRTCIRNTCVKGKNMENPEGYA
QLIKKADPDYVEVKAYMCVGSSRERLTLDNMPTFNEVKDFAQKIGDACGKEIVNESEISR
VVLLE
>A0A673K6K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
QELSAETEKVIHVSGVKVFYGSQTGTAKDVFERNFLRSLILKMICVFLVATYTDGQPTES
AEWFSKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARI
MTRGEGDCNVVKSRHGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHK
EEAEDSHSLAEKNNSEEELMESSSDAESSSEEEKFHGSVIDVEDLGNVMNHMKKAKVKTK
PAPPTLNLDISFGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCGFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNMIRQFKGVPGVRPERFEEGL
TVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALG
QPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLL
AHHKFKVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDP
SDTRFQRKNKTKDISGC
>A0A8J4N5Q1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eudyptes sclateri|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKYNGN
PASSEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
SMGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WRAKFLSRLQALCRGERKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFET
SSEEEADAEEAGGTNSVIDVEDLGDIMSHMKKAKSGLDSRVGGGMYHPFPRLSRNPIRTR
ILAAQGGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCA
LSLVGEPIMYPEINRFVKLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIE
VKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFK
INGEWCTWINYDRFQELVQEHERSGGSKTFTAADYAARTPLWALFGSRERGFDPLDVRYQ
RKNKARDISGC
>A0A419WRM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halopiger aswanensis|TrEMBL
MSDSESGPKQVDSPDYHSENHTAAQTCGWTANALRGEGRCYKNVWYGIESHRCIQMTPVV
KCNERCVFCWRDHRGHAYELDDVEWDDPEAVADASIDLQKKLLSGFGGNDEVPRERFEEA
MEPRHVAISLDGEPTLYPYLPELLEAFHERDITTFLVSNGTNPDVLRECDPTQLYVSVDA
PERHTFDQVVKAVEDDAWERLLETMDVLREKEETRTVLRTTLVDGENMHHPDWYAGFYQQ
ADPDFIELKAYMHVGHSQGRLDRSSMPDHEDVVAFAEDVREYMPEFDELKGVPPSRVALL
AKTEDTWVPKLKKDSDFWARDPVTGD
>F6V9G2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ciona intestinalis|TrEMBL
VLFLVSTYTDGVPPLTCKWFCQWLHEASNDFRVNKSILAGMKYAVFGLGNSLYSDNYNTV
GRNIDKWLHKLSASRVFPFTEGDENVAQSKQGSLKLDFDSWKNDIISILPGNFARLTMNA
SIGIIESESEDVENSESEEDKEEDDVVDVEDVGKAMSNNVNGVLVKRKSTKAKREMITPE
LSKSLTKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHSNPVGTEWKWKMDSPDIVVKGAVNNHYDMIKQFKKQGVPGVKPERFAEGFSI
KHCALSLVGEPIMYPEINKFVQLLHEKGISSFLVTNAQFPEAITNLIPVTQLYVSVDAAT
QESLKKIDRPLFKDFWPRFIKSLKALSAKGQRTVYRLTIVKAWNSDEIEAYANLVSLGKP
DFIEVKGVTFCGDSKSSDGLTLKNVPWHEEVVNFVDQLAQMLDGYEIASEHEHSNCVLLA
QTKFKISDGGWNTWIDYSRFHELYQRYQATGECFTALDYMKKTPPWALFGAKERGFDPVE
TRWRLGYMQAPKPPSHGA
>A0A2J7ZV97|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetrabaena socialis|TrEMBL
MDVGGVRAGGAVAEVDVESRSADDKSQPSNVNRAVQAASTPVAGAPAAVKILYGSTKGNC
KLLAAELAERLSSALALAGAADNSGCCGGSGAASAAAGGGCCAATTAGAAASSPGACATQ
PRVQVCDVAAFEPEQLLAEAPETLVVLLVSTYEGGTPPESARFFCSWLEDAASDFRLGAA
ALNHLRFAVWGCGNSLYAVNYNAVARRVERQMLELGARRFRPLGLGDEDAGDMREQFLPW
REALVGKLVPTAAGGGTAVGAQQAGARAAEGAAPGSPAEESDAGDDDDEEEEEEEEEEEE
EEDDEGGGGEGQGSEGDMEDIGGSGPRRGKAAKSASAAAAAAGGDGGPPEMLNPLLRGSL
TKQGYKLIGSHSGVKMCRWTKSQLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCW
RHHSNPVGKTWKWKMDPPDVIVDTALELHTRMIREYSGVPGVKPEAVAEGLKAVDRPLFS
DFWDRFTGCLSALAAKRQRTVYRLTLVKGWNMTEVESYAALVDLGRPDFIEIKGVTYCGS
SGASSLTMANVPYHVDVKEFGQAICTARGGEYALVCEHAHSCCILLARADRFLVNGVWHT
HIDYDRFQDLLASGAEFSATDYMLPTPAWAMYGSTEAGFDPAQQRVKKVRRHPGRSDTAS
VAEAGEEDE
>A0A8J6L243|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microtus ochrogaster|TrEMBL
MNRFYIYLGCALGVTLWICVQVVIKKQVVRSQERSVPGAPDGSPSLQQRQTHVSGVKIFY
GSQTGTAKGFAVTLAEAVTSLHLPVAIVNLKEYDPDDNLIGEIASKNVCAFLVATYTDGC
PTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQNHFNKVGTNVDKWLWMLG
ANRVLTRGEGDRNAVQSKHGSIEADFTAWKTKFTSRLQALQSGEKTACSGDCKRGKCESS
QPGSGEVRPHLQGDLHPRDAEEEEPCESSSEEESGSQDYQSLNSVVDVEDLGNIVSPMRK
EKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
LIVKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQ
QGISSFLVTNAQFPEEIRNLTPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKAL
AAKQQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYCGESAASNLTMANVPW
HEEVVRFVQELVALLPDYEIACEHEHSNCLLIGHKKFKVSGEWWTWIDYSRFRELVLRYE
ESGGAKTFSASDYMARTPRWALFGARERGFDPKDTRYQRKNKAKDISGC
>A0A0F4GDA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zymoseptoria brevis|TrEMBL
MEDSYLLRLPRELLLLWHAHRMEILISAGFLVAIVRLTLHWRSTKTKVILTPPLGSPVTE
KPIRFPEVVQEKTVPPAQPVKTNGPRRVKGVKKVKKQEPAKDQRPPIDKIQPYIFYFTLG
GSTKAYAEKLAESFILPDAEARVLPPQVHDLTDIDYDDFFISPPKYDSPGTGAFYTILIP
SYNIDTELHNFLSHLQETHHDFRIDTAPLQTLAGYSVFGFGDMQEWPTEQEGYCVQAIEV
DKWMAKLTGKKRAYPLGMGDVKDDVELRLEEWRRGVQMIVDDLSQGKGLGEGVLGSGDPV
ESGDEADEDYDDGETLITTTADLEDIRAPIPIDFTTSTKKSSSTTTGPPKAMVPVNSPTF
NSLTKQGYSIIGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCV
FCWRHGSNPVGTTWRWQVDPPEQIFEGILAAHYKKIKSLRGVPGVRSERFAEAMRVRHCA
LSLVGEPIFYPHINQLLAMLHAQHISSFLVCNAQHPAHLAALGPVTQLYVSIDASNRDSL
RKIDRPLHRDFWERFCDCMDILRAKRYSHRTVFRLTLVKGFNIADEVAGYADLVQRARPG
FIEVKGVTYCGTSTSAGAGLSMANVPFWEEVQEFVLALAAELKTRGVENDGMEYGLAAEH
QHSCCVLLADKERFYRKNAAGEGKWHTLIDYEKFFKLVERGGEFKAEDYVSAEPTADWAG
WGRGGFDPRDVRVDRKGRPIEAKDEGRVVEI
>Q4CXG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi (strain CL Brener)|TrEMBL
MTESVSEALWWVLLGALIPLVTLTLTTLLDRWVSRRRKRQMEVARAQAAKEGKTTWMEPN
VHNSTGKTNGNGSTIHDAVKGSKGGVDVKKILIAYATQSNTACKLAHKLFSTLSTALHES
RDEMQGGSSSCVCSEGPSSCCATSHTARHLPKLKVLQLTEEGRQCGVEYLLESQAYGLVI
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKFAIFGLGDIAYGEKHFNRFA
KNLYMWCKGLGATFVVPPVYASEANTIPLFNVFAASLVKWVGRVTFTADGVTILKRQQKQ
LKEKKEKGQLKLCNDVKLQGHATYNSEEDEEDEEREEEDEENGRKKRNHNSEGDVEDVVT
DDEDEGEDVNGQSGSVDHAVRALSSEPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTK
AMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRSFRWKVDPPQLL
IAEGIAGHQKMMKQMRGVPGVTPERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHERG
ISSFMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRR
KPQRTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLTMKENVPRH
EEVVRFCAALCEALASDTAPRDKRTWLGTEPETGPLQRDLNCDEKRTSVNNMENNNRRCN
RKDEEEGVGINFSGPYSIACEHEHSCCVLIALRRFLVNGVWHTWIDYEKFNALARSGRTE
FTAAEYAAPTPSWAVFRSNEKGFDPTQVRV
>Q4CKR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi (strain CL Brener)|TrEMBL
TQSNTACKLAHKLFSALSTALHESRDEVQGGSSSCVCSEGPSSCCATSHTARHLPELKVL
QLTEEGRQCGVEHLLESQAYGLIILIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTL
AKKKLAIFGLGDIAYGEKHFNRFAKNVYMWCKGLGATFVVPPVYASEANTIPLFNMFTAS
LVKWVGRVTFTADGVTILKRQQKQLKEKEQLKLCNDVELKGHATYNSEEDEEDEEREEED
EENGRKKRNHNSEGDVEDVVTDDEDEGEDANGQSGSVDHAVQASSSEPPELLYPRLRQNL
QRQGYHLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCW
RHHTNPVSRTFRWKVDPPQLLIAEGIAGHQKMMKQMRGVPGVTSERLEEGMHVRHCALSL
VGEPIMYPEINTFVDLLHERGISSFMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRV
>A0A218ZEF6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marssonina coronariae|TrEMBL
MAHDTWTFRPSLPLLPMEIDGVVALWHLHRIPIILTAVTTLIIIRISLHLRFPRHKITDS
PPNLPYLPAPKENSAPPERKAAAEKAPRRIVGGLKKRKSSQENVIPKEQKIQVLVFFSSL
TGMTEKTAKAFTEGLAQSTKKIAEATSTIFLLPELLDLSYVDFDEYFIDPPKSEAGAQYF
YLLLLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSQILGYSVFGFGDREGWPTEEEGFC
SQARDVDRWMAKLTARKRAYPLGMGDSKKDAAERLEEWKEGVQDVLGHIAATGSLGEGVV
GSGDAVESDAEDVDEEDEILFDMKKVARKKTIVQKKHALNDLEDIGSSMNNQLDKPEADL
EEPLELDFTAYSKKPQPQVATVIKEMVPPNSPTYTALTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDAPELIFD
GVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHIS
SFLVCNAQHPDQLATLAPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRERR
FEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPSFVEVKGVTYCGTSSSAGAGLTMQNVP
FYSEVCAFVVALNAALAKRGLGYGIAAEHAHSCCILLASERFRVAGKWHTRIDYDKFFAC
LESGERFTPEDYMGPETPEWATWGKGGFDPRDVRVFRKGKNKVALAEKQAEVMEI
>A0A849PYF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVIEEDDRLIQIKPAITEQLKKAKYGVADHSTVGLCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMEMKPEEVAEPEAILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEETKSIFLVTNGQE
PDMIQKLQDEDALPTQLYLSTNAADRESFLRINKPKYDDSWERWNKTLGMLKHLNTRTVL
RITLIRNYNDQNEMIPAFAEMVKKASPHFIEIKSYMHIGRSTNRLEHENMLEMYEVKKFS
EQIAEQSKIFSIMDESIISRISVLQNNERLIDRLIPTYANTN
>A0A3M6K6S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVVDGEEQLIQIKPAITEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLDMLKHLNTRTVL
RITLIRGYNDQMDMIPTFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKRFS
EEVAKQSQIFSVMDESFVSRISILQNNERFIDRWIPTYANTS
>A0A3B3ZKF6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Periophthalmus magnuspinnatus|TrEMBL
ALLFGIWFSVKMALKKKSVSSDTNSSHKPAKSSGCSDKEKVVHVSGVKIFYGSQTGTAKG
FAKELSAEVEASGLPCEVIDLKDYDPDDQLADEGTNKIVCVFLLATYTDGQPTENAEWFC
KWLEEASTDFRYGKTYLKGLKYAIFGLGNSVYTGHYNTVGKTVDKWLWMLSASRIMTRGE
GDCNVVNSKHGSIQADFIAWKVKFLNRLKKLVKGDKKTCSGNCKNGGSCKNKTKHEHEHE
EEGDAVQSTNNEEDLFESSSDDEESALQDERKGPVVDMEDLGNIINGVKKAKVRKMEEDK
DEEQMVKLSKLNGFKRAEDEEEKREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRYVYTTWAQSGAGRKILNDSLEKHQ
NMIREFKGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFLHLLHSHRISSFLVTNA
QFPEEIRNLVPVTQLYVSVDASTKNSLKKIDRPLFKDFWPRFLDCLKALGEKKQRTVYRL
TLVKAWNVEEMLAYADLIAMGQPDFIEVKGVTYCGESTASSLTMANVPWHQEVVSFVQQL
ADMLPQYEIACEHEHSNCLLIAHTKFKIDGEWWTWIDYERFQELVQAYEDTGGQQSFSSL
DYMAKTPAWALFGAEEQGFDPADTRFQRRNKTKNISGC
>A0A835VPZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chlamydomonas incerta|TrEMBL
MELLASLYTFGQVLWGIIVGAIIIAILRATKRGDGDDATSKDSGTAQAHASAGDAASPAA
AKDSTAPSSGDGGAASSATRRLPAPAAPAAVAVAATAAIAPVATQAPAPVVSVAAPAVAT
APLPTAAAAPVIARPAAPQPAAPATTASPALAAAPAAAAAAIAAANTTTTNNTAASITSA
ADAAVAPPVKIIYGSTRGTCKGLAEALAERLLAAAAAAAPAPPTDAAAASNNACCGSGAA
AASVADAGGCCRTADGEAAAAPADCCRQQQPASPAAGSPATPATATTATKTAAAAPPPPP
FSTVTVVSAADYEPEQLLTEPRDTLVLLVIATYEGGTPPASAAFFCSWLEDAASDFRLGA
GALGRLRFAVWGAGNSLYEAAYCAAARRAEGQLLDLGARRFRPLGLGDEDAGDLRAQFAA
WAERLVAKLVPQEAAAAAAAAEAGKVEEEALDAAAGAEEGEEQEEDDSFEYEDEDEEGAG
SEVDIEDIGGAGPRRGKKGAAAGAAGAAANGGAEGGPPEMLNALVRGSLTKQGYKIIGSH
SGVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKTW
KWKMDPPDLIVDTALELHCRMVREYSGVPGVKPEAVAEGLAPRHCALSLVGEPIMYPEIN
ALVGRLHARGLSTFLVTNAQFPDRIQQLSPVTQLYVSVDAATPASLKAVDRPLFADFWER
FTGCLAALRDKRQRTVYRLTLVKGWNMEEVLEYAKLVDLGRPDFIEIKGVTYCGSGGASS
LTMANVPYHADVVAFGRAICEARGGEYGLACEHAHSCCILLARVDKFLRGGTWHTWIDYD
RFQQLAAAGGDFGAEDYMLPTPDWAEFGSEAAGFDPGQVRVKKVRRHPGRTGTDSESVVG
ADDVALEEL
>A0A0L6VDN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia sorghi|TrEMBL
MLSLVESITNRFSFINSSENDQLENPFNTQILYSSLSSTTKNLANQLARNLKSSSKHLNP
SLESLDHLDLDQLITQTPVHSSHQLAILLLPSYNVESPVDSVLAQFRDALFDFRLSKNSL
AGLSYAVIGIGHSDYLDDFCKQAVELDQILEKLGARRLIPLKKIDVSVDPERDIEDYCNS
TIQNTLTSSLKSFSELPTIKSEQVNDSSENEEEDQDIDNSDDEFVDYSNSKPLSKAEIAR
QKSKKLLKQKTNQALKNSNGTLDIEDLGAGVPQIENLPANSTKDPANQMIKKDMISPMTR
KSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLACANKCT
FCWRSHTNPVGTSWRWKTDDAEFVVEESLKEHDRLIKQLAGMPGVRPDRFTEARTPRHAA
LSLVGEPVMFQSLLDLPPVTQLYLSIDAGTKESLKSIDRPLHRDFWERFLESIDIVRQKR
IRTVFRLTLVKGENSAEIKEYAELVRRGQPDFIEVKGVTYCGYPGSSNLTIKNSPWHNEV
IKFVEDLCEEINDPRYRAANDTAHVAEYGLAAEHAHSCCVLAAHRKYYFDDRWHTWIDYD
KFFELVESGKKQFDGLEYCVETPEFALFGSPEAGFSPEDQRWFRKKTLAKQALLADPPLV
DAQ
>A0A0V1CQ56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella britovi|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNVRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENEN
SSDAEDAENSANNVGDIEDICERCVVMIHFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLV
GTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVG
TEWKWKTDPAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYP
HINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDF
WQRLMNSIDILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSK
DSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDY
EKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A671WMX0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sparus aurata|TrEMBL
MSSFFVVVLLFVGRVSSSDTKVSQNAYSTTESYFMSIWHNRLYLYSAAALVFGIWFSLKV
ALKKKSFSKDVGTLVYRAVKNNDRDTVVHLSGVKIFYGSQTGTAKGFAQELSEEVKTLGI
PAEVIDMKDYDPDDQLADECSNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGK
TYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRVMTRGEGDCNVVKSRNGSVQ
ADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGSCKSKRRDTQEEEEEEEEKAALKNNGS
EEELIESSSDDEESGPQDEEKSASVVDVEDLGNIMNSVKKAKSKDESRGDGQMVKLSKLN
GMGKIEDEGERREMITPALRDALTKQDITPILWAQSGAGRWILQEKILQDSLEKHQNMIR
QFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQ
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVK
AWNVEEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADML
PQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQTHEESGGRQSFSALDYTA
KTPSWALFGANEQGFDPADTRFQRRNKTKDISGC
>A0A8E7EJU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum sp. J.3.6.1-F.2.7.3|TrEMBL
MHSGQCEPPEKALRGMGYQFFHPDSSAALKPCLWCKRSLTGGDQCYKNQFYGITSHRCVQ
MTPTLRCNHKCLFCWRSFEHEYTGEKDLDPKEIVARIPFLQKKALGGYKVSPRVTKGKWE
DALQPDQYAISLSGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPDVLKQCHPYQKYISL
TGPDRETYLRIARPDEDYWDRILESLSDLGHETDTGHRTAIRVTLVRGINDQNPEGYARI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHDEVERFTQRMLPHLSYKIRGENSLSRVI
CLERDS
>A0A671WG45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sparus aurata|TrEMBL
AIVFIEKIMYSNAYSTTESYFMSIWHNRLYLYSAAALVFGIWFSLKVALKKVNSLLAHII
TSLAHSSVKNNDRDTVVHLSGVKIFYGSQTGTAKGFAQELSEEVKTLGIPAEVIDMKDYD
PDDQLADECSNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVF
GLGNSVYVGHYNTVGKNVDKWLWMLSGMRVMTRGEGDCNVVKSRNGSVQADFLAWKVKFL
NRLQALAKGEKKSCSGNCKTGGSCKSKRRDTQEEEEEEEEKAALKNNGSEELIESSSDDE
ESGPQDEEKSASVVDVEDLGNIMNSVKKAKSKDESRGDGQMVKLSKLNGMGKIEDEGERR
EMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDPKHQNMIRQFRGVPGVKPERYEEGLAVKHCALS
LVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKK
IDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFVEVK
GVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVD
GEWWTWIDYERFQELVQTHEESGGRQSFSALDYTAKTPSWALFGANEQGFDPADTRFQRR
NKTKDISGC
>A0A2G1NW43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ex4572_44|TrEMBL
MSHEIQELLKKHGYQRAGRHSAVKTCLWLKRSINNKGQCYKSQFYGITSHRCIQMTPTLQ
CNQRCLHCWRAIDATIPKTPWDPPEVIVDETLRAQQRLTSGYGGSDQANKKLWEESKNPL
HVAISLAGEPTLYPYLSELINIFHKKGMTTFVVSNGTHPEVIREINPTQLYLSLTAPDRE
TYQQTCKPEREEMWEDLLKSLKILSGKKGRTTIRITLIEGLNDTKPEEYAKLIKLAKPDY
IEIKSYMHLGFSRKRLERNKMPTHTKINKFAQKIIEHTEYKWADENEPSRVVLLSKDGKT
DKL
>V7PS69|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium yoelii 17X|TrEMBL
MITKREDEIVLPPNEVANINIYSIQKKAKINLTLIYGSENITSYNAGKTFLNELINFFND
ILNNFNIINTITKGDKKNDRNFEGSISNEINNIEDYMFKYFRSKLLKKNKDGNSEKKWKN
ESAKLKNESAKLKNEAKDNFDNLKKYEKNIIKCGNTHFNNYLNCSIKNNVSEITFSLVNG
NEFDSYTFFENSENNDLNFLFMFISTYNFGAFPANCYKLEDVLTDLINDFRIEKNYLKNI
FYSCVGFGNKEYGNTYFCTPIKKCDKFLSSLGANKLEKTIKLCSTMDNEEEIIQWKSNLL
TKICLSLFLYNFNYTKFSNNFFHYSNRKNYNTLKYYCTYFCKKNEDVKNRIINDKQNEQT
TNLLNNNNIKKGDSINNDQNKLINNINGHISLFTSNIDGNSDEKCGCTSNNCLNGNDKYI
NKKKIINNNFETPIVNECCKKEYDKNDELINSDVNSESMSENNDEINCNSSEELEDLLSN
KIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMEA
TPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVSEAVKKHKNMIKELKGVQNVINER
FENAKNIKHCALSLVGEPIMYPDINNLIDELHKKNISTFLVTNAQFPNELKKLKKVTQLY
ISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKEKKERTVFRFTLVKEYNMMSDEISSY
AKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLINSKPSISDIYEIS
CEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVKQNANFTAIDYCEETPEWAVIGAPE
CGFNPSDQRVYTKGKNKNKNNINTMEIKT
>A0A7S8DQX9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium pseudograminearum|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEQVEIEEKTPTIEPVEEKKNVKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPLVFFCSVTTKTAKIAQAYVERLGGKLDEVSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKAHGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A024VUC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum FCH/4|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKGDLSIYPMEQLEGCHCN
KAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGNDEKDIVNEH
KTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDTSNTNDTNNTNIMNNTN
NTNIMNNTNNTNIMNYTNNTNIMNYTNNIRTGENCVSESETSSNQSYPDDEDEQIEVEDL
ISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQC
MEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGII
MERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPQELENLNTVT
QLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEI
DSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINKKKALSHIY
EISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVETPHWAIYG
SQESGFSPCEKRVYTKGKYKNKNQQS
>A0A3P8ZRS2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
MLQGSTLLLLDFITDILCADIDGKKTVRSTLESYILLVWQNRLYLYTAAAVFVGIWFSMK
IALKKKILTTPVNPWLYKSVKQNVYSVENVNVVHVSEVKIFYGSQTGTAKGFANELEEEV
KTLGIAAKVIDMKDYDPDDRLADECSTKSICVFLLATYTDGQPTENAKWFCKWLEEASTD
FRYGNNYLKGLRYAVFGLGNSVYDSHFNTVSKNVDKWLWKLSGVRVLSRGDGDCNVVKSR
HGSLHSDFLVWKTKFLSRLQTMVAGPKACRGKCKTGGSCNNRKKPQKTDDEQAAPEQLSS
EEELVESSSEEEAAGTGPDEQHPGSVIDVEDLGNMMNGMRKAKVRPRSGVQICDHITFST
FCSTGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDPPEKILLEAVENHQNMIRQFRGVPGVRLERYQEGLKVKHCALS
LVGEPIMYPEINAFLCLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKK
IDRPLFKDFWTRFLDSLKALGEKRQRTVYRLTLVKAWNVDELKSYSELISLGQPDFIEVK
GVTYCGESSASSLTMANVPWHEEVIHFVQQLVDMLPQYQIACEHEHSNCLLIAHTKFKVD
GEWWTWIDYERFQELVQAYEESGGSQTFSAMDYMAKTPMWALFGASERGFDPTDTRYQRR
HKTKDISGC
>A0A3P8XV76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
VSEIINSIRSTLESYILLVWQNRLYLYTAAAVFVGIWFSMKIALKKKILTTPVNPWLYKS
VKQNVYSVENVNVVHVSEVKIFYGSQTGTAKGFANELEEEVKTLGIAAKVIDMKDYDPDD
RLADECSTKSICVFLLATYTDGQPTENAKWFCKWLEEASTDFRYGNNYLKGLRYAVFGLG
NSVYDSHFNTVSKNVDKWLWKLSGVRVLSRGDGDCNVVKSRHGSLHSDFLVWKTKFLSRL
QTMVAGPKACRGKCKTGGSCNNRKKPQKTDDEQAAPEQLSSEEELVESSSEEEAAGTGPD
EQHPGSVIDVEDLGNMMNGMRKAKVRPRSGVQICDHITFSTFCSTGYKLIGSHSGVKLCR
WTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPP
EKILLEAVENHQNMIRQFRGVPGVRLERYQEGLKVKHCALSLVGEPIMYPEINAFLCLLH
SQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWTRFLDSLKA
LGEKRQRTVYRLTLVKAWNVDELKSYSELISLGQPDFIEVKGVTYCGESSASSLTMANVP
WHEEVIHFVQQLVDMLPQYQIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAY
EESGGSQTFSAMDYMAKTPMWALFGASERGFDPTDTRYQRRHKTKDISGC
>A0A8J4BAA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Volvox africanus|TrEMBL
MDLFSYFVLVIKALWLFGLAKASLNLWRTSRARSTSPKANPANLSSENLGRNAIESAAVK
AIKTAPTQNGCCAQSGATPPATTNCRHAPEQNQNVSFVKVAAEVVAPSVKILYGTTTGTC
KELATHLSELFSVGLLSLSPSVVSVTTCGSANCCRSADAPTAVSAAGAPADLASYEPEQL
LSEPADTLVVFLISTYEGGSPPQSAKFFCSWLEDAASDFRLGSAALSHLRFAVWGCGNSL
YEGHFNVVARRMDRQLRELGANRFRPLGLGDEEAELDLRQQFVPWAKELVVRELRRWQQQ
QQQQQQPPTGPAMEVGANGSAVSRAAAGRGAGATEATPTATEDGVHQDMEDEEYEEDYEE
EEEEGAGSEMDMEDIGGAGPRRSKARTGAGAGAASAASPGPESGPPEMLNPLIRGSLTKQ
GYKLIGSHSGVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHH
SNPVGKTWKWRMDPPDTIVETALDLHTRMVREYSGVPGVKPEAVAEGLQVRHCALSLVGE
PIMYPEINALVDQLHSRGISTFLVTNAQFPDRIEQLNPVTQLYVSVDAATPESLKAVDRP
LFSDYWERFTACLSALRSKRQRTVYRLTLVKGWNMAELQAYASLVDLGRPDFIEIKGVTY
CGSGAASSLTMANVPYHADVVEFGQAICAARQGDYALACEHAHSCCILLARVDKFLVEGQ
WHTWIDYEKFQRLVREGGDFGAEDYMLATPSWAVFGSEQAGFDPEQMRVRKVRRHPGKSD
SAAVSVAGEAVEEDS
>A0A7L2MR38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhadina sibilatrix|TrEMBL
LDVSMDPWSYFHTCLVSIWLHRLYIYSAVAFGISLWIVIQFTATGTKRKVGEGLLQDLGA
DKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFARTLAEAVTSLNLPVEVINMGDYDPE
DGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAASDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVIQSRHGSIEADFEAWKAKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGASEHENTEAEELFETSSEEETGG
TDPVIDVEDLGNIMGHMKKAKVLLLEGVWNGAAGHLCCHSGYHLVCFVCQFLQAKLNCLM
ICALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEVILQEALEKHQNMIKQFKGVSGVKAARLEEALAVKHCA
LSLVGEPIMYPHINRLVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESL
RRIDRPLFKDFWQRFLDSLKALAEKVPTT
>A0A0D9P1N4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium anisopliae BRIP 53293|TrEMBL
MSAVCDKPDPLQGVFGGLPGAKFDDIVELWHGHRTPIIICALVVLVVIRIYIHKIEEAEP
LRALPKQFEKRTEPLSANKLPSAVNSEKPIAKPNGPRRIKGGITKKPATEETKEYDKSRP
IKTMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGTERQFLKPELHDLAEIDFEDFFVSP
AKTVEDAHLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGFGDKE
GWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVQEVIAHVA
SSGTLGEGAPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGRMLRT
SDGNGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYSIVGS
HSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHI
NEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTS
TSSNAGLSMSNVPFYWEVCEFVKALEARLKAKGLKYGIAAEHAHSCCILLASERFLVNGK
WHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIEN
VVVREAPPPDSW
>A0A3M7C3L0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MPIAPGECTAAHVATNIHPPPMLDMEKILQLPEELLFLWHTHRAEVLLSAGLLFALLRLA
VHWRTRKSKEVLTPPVLTPVDEKPLAVPSAKETLADADHYEAPTPKPAVQRPKPGPKRVT
GTKKSKSAASQEAQVIEKIQPIIFYYTLGGSTKVYAESVAQDLTTSSPSRILEPQLHDLA
DTEYDDFFLSIPKAEETAHFYLLLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSKLAG
YSVFGLGDKHEWPSEAEGFCTQAVDADKWMARLTGRKRGFPLGFGDVSKKDEADVMLKEW
TEGVSSIMKDLAEGKGLGEGVPGSGEPIESADEASEDEDETSAPRKSKRKPAKRSKTDDL
EDLKAPIPVDFTTSKPTSTTQPPPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPV
FQGMKEGHYKKIKMMRGVPGVRAERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRER
ISSFLVCNAQHPDQLEALGPVTQLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGR
KRFTHRTVFRLTLVKGFNIEEEAEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQN
VPFYQEVTAFVLALEKALANRGLDYGIGAEHAHSCCILLADRERFYRIPEAEKDNPAAEK
KWHTLIDYPRFFDCLESGRPFSPEDYVGPPTPEWALWGNGGFDPRDERVDRKGRPKEQPK
VQEVQE
>A0A1U8CKH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mesocricetus auratus|TrEMBL
MGPPLDVWDFSSPLLLLWMNRFYIYLGCALGITLWICVQVVIKKQVIRSQEKSVPGAPDS
SLPLQKKQTHVSGVKIFYGSQTGTAKGFAVTLAKAVTSLDLPVAIINLKEYDPDDNLIGE
ITSKNVCAFLVATYTDGRPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQ
SHFNKVSTNVDKWLWMLGAQRVLTRGEGDRNAVQSKHGSIEADFTAWKTKFISRLQALQS
GEKKACSGDCKKGKCETTQPGAGEEEEPCESSSEEESGAQGYQSLNSLVDVEDLGNIMNP
MQKEKRERAQQEEKAGVKRNPETSVDSEGRAMITPALREALTKQGYQLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIDSHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
LILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMYPEINRLLKLLHQ
HGISSFLVTNAQFPEEIRNLTPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKAL
AAKQQRTVYRLTLVKCWNVEELQAYAELVSLGNPDFIEVKGVTYCGESAASNLTMANVPW
HEEVVRFVQELVDLLPDYEIACEHEHSNCLLIGHKKFKISGEWWTWIDYSRFQELVLQYE
ESGGSKTFSASDYMARTPQWALFGARERGFDPKDTRYQRKNKAKDVSGC
>A0A8C3HMX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chrysemys picta bellii|TrEMBL
MLNFWLVFQVLTILAACADAHAMDASADTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWIC
FQFIATKAKKQDEKSTEKLTPSKVTQDVLINGYTMPKTKEVYVAGVKVFYGSQTGTAKGF
ATILAEAILSLNLPAEIINMRDYDPDDCLVEEATSKNICVFLVATYTDGQPTENAAWFCK
WLEEAVNDFRFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEG
DCNVAKSKHGSIEADFSAWKARFLARLQALCKGEKKPCSGNCKKGKCKSKGKKSKEGSDH
EQRVSEQENTEVEDLFETTSEEELGAEEDGSHNSVIDVEDLGKIMGHMKKAKKECELEEE
AGRTGPSQQSSGKNEESERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREAIENH
QSLIKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTN
AQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYR
LTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRE
LADLIPDYDIACEHEHSNCLLIAHKKSHVAGFDVPLMWSPIFCNHSSHLPDGADRRTWRG
ADEM
>A0A8C3HNG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chrysemys picta bellii|TrEMBL
MLNFWLVFQVLTILAACADAHAMDASADTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWIC
FQFIATKAKKQDEKSTEKLTPSKVTQDVLINGYTMPKTKEVYVAGVKVFYGSQTGTAKGF
ATILAEAILSLNLPAEIINMRDYDPDDCLVEEATSKNICVFLVATYTDGQPTENAAWFCK
WLEEAVNDFRFGKTYLKGMRYAVFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEG
DCNVAKSKHGSIEADFSAWKARFLARLQALCKGEKKPCSGNCKKGKCKSKGKKSKEGSDH
EQRVSEQENTEVEDLFETTSEEELGAEEDGSHNSVIDVEDLGKIMGHMKKAKKECELEEE
AGRTGPSQQSSGKNEESERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILREAIENH
QSLIKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTN
AQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYR
LTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRE
LADLIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWIDYDRFQELVQEYENSRGSKTFTA
ADYVAKTPHWAMFGSRERGFDPLDTRFQRKNKTKDISGC
>A1RYH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum pendens (strain DSM 2475 / Hrk 5)|TrEMBL
MSVSPMQEAQRLDVARYLRAGYKLVGNHSAVAVCRWTRSALRGERLCYKSWYGIQSHRCL
QMTPVLNFCDFACKFCWRMHLPGRFKLPPGWRWDEPEDIINGSIVAQRLLLIGFKGNPKV
SRERFLEAMFPRHFTISLDGEPSLYPKLAELVKKVKERNFTAFLVTNGSIPIRLEELVKR
DAQPTNLYLSLYGPNKEVFTATADPRIPNAWENVLRSLELLDRFTESRTVLRLTMVKDLN
MVDPEGYSKLIKLGNPMFVELKGYTWVGESQKRLPISAMPTIEELEKFAKKLEELTGYKV
KVEDDKSRVVMLVRDEDVWERNLKMVEEWRARVAKLDESWRSKVEDFTMEEHGKILYY
>A0A124ITD5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoproteus sp. JCHS_4|TrEMBL
MSCEEEPIGRHHAVVGPRLVIRAGTARRLVEAHYGVAGHATVELCKWTRDALDGEGSCYK
VKFYNAPAGGSHRCVEMSPVGMVCSNRCIYCWRPTQEFDEFIPEEWWAMEPEEVVKGVLK
ERERLLSGYWGHEKARGRVKEALAPTHWAISLSGEPTLYPKLPQLVKLIRSLPHTKSIFI
VTNGQHPEMLERLVKEDALPTQLYLSMNAPNKELYYLINVPVMNKEDAWERWLRSLDLLA
AMPTRTVVRITLIRSMNYDERYIPLFAQLVKRGQPHFVEVKSYMHLGYSTRRLRREDMLA
HEEVVEWAKRLRDELERIGARYAYMDDDERSRIAVLQNLDRYVDRWIVPPQAR
>A0A2T6J3W5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii TgCATBr9|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKVRGKAKPEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGEYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A0L1L0F1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsela sp. CCAP 1560/4|TrEMBL
MESDSDVPCAVVLPMTEIDVDNFASLEESSPSDVMQPTTFSLATREPLQSAPPTIANQKV
LNVFVVSTYAGGSPPQNAVSIFNLIDDMSQDFRVSGNAWENHHFAILGCGEQVYGKNFNR
FAISLQEVLSRKGGYAIFGKPHLSDIDTTERDTAKFIVRLKKYLSAETKCTPVITAKPKK
QRKESAEADIEEAAGTEDGAADEMINPRIRQGLTKQGYTLFGTHSGVKLCRWTKSMMRGH
GGCYKHTFYGISSLACMEMTPSLACANKCVFCWRHHTNPTAREWRWKHDPPEFVINGALD
GHRRMLKVLRGVPGVTEERLREAMQVRHCALSLVGEPIIYPEINKLIQLMHQNEISTFLV
TNAQFPDRIRDLPPATQLYVSVDAGDKASLQAIDRPIFEDFWDRYLECIRLLALKKQRTV
FRLTLVKNYNVEQIDGYISLVRLGKPEFIEVKGVTYCGDNGEDGISMRNVPYHHEVIDFC
KLLLERIGDTYDIACEHEHSCCVLLARKEFKIDGVWHTWINYSKFFELARSGEPFTSMDY
LLPTPDWGVYGSAEKGFDPSQIKKKLRHKGPIAGGC
>A0A8H7TLZ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cadophora malorum|TrEMBL
MAHDTWTLRPLLPFEIADIVAVWHIYRIPIILTTVISLIIVRTFLHLRFPRHKITDTPPI
SPALPALKEKPAPSEKKSVAEKAPRRIVGGLKKRKSSQEDIKPDGNKIQVLVFFSSLTGT
TEKTAKVFTEALAQSTQRLEETTSATFLQPEILDLSYIDYDEYFINPPKSEAGAQYFYLL
LLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEGFCSQA
RDVDKWMAKLTGRKRAFPLGMGDTKKDATDRLSEWKEGIEDVLGHIATTGSLGEGVVGSG
DAVESDVEDVDDEDDVLFDEQKVAQRKTKVQKKEALNDLEDIGSTLNKTEVPEADLEELE
LDFTTYSKKPASKAATVIKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSALRGRG
SCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEMIFDGVKAG
HYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVC
NAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRERRFEQRT
VFRLTLVKGFNIEDEAEGYAALVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEV
CAFVEALNAALARRGLGYGIAAEHAHSCCILLASERFRVEGKWHTRIDYQKFFACLESGE
GFRPEDYMGPETPEWATWGNGGFDPRDERVFRKGKNKVALTEKQGEVMEI
>A0A1Y2VG79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hypoxylon sp. CO27-5|TrEMBL
MASRVGELGADANAPFQSILELWHEHRLAILFATTCILTVFWLYIEPRQKVNLRIETHKS
TQGATKPIADDEPKALGEKVVVRTEKIKDATTGPRRIKGELRRADTARQSPERNPERPIQ
TLVFYSSLTGSTERTASGFAQNLGASLRAQVDGSGKSFLSPIVLDLAEVDYDEYFISVPK
PADPNTSVDYFYLLLVPSYNIDSINDNFLEHMKETCHDFRIDTSSLSGVLGYSVFGFGDR
EGWPTEDEGFCFQAKEVDKWMARLTGRKRAYPLGMADTKRDLRERLDEWMDGVKDTLTHI
ARTGSLGEGVPGSGDAVESDDEYGSADDDDGEVIIEQSAATRKPKKARSGNIDDVEDLGR
IMKASQNGSEKSNNPTAIAVDFTTYNKPTSKRPIQTIKEMVPKNSPTYASLTKQGYSIVG
SHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPEMIFDGVKAGHYKKIKMLRGIPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLALLHGERISSFLVCNAQHPEQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFW
ERFQRCLDILREKRFKQRTVFRLTLVKGFNVEDEVEGYADLVEKGLPCFVEIKGVTYCGT
SSSAGAGLSMANVPFYAEVTEFVTALEKKLRERGLAYGIAAEHAHSCCVLIASERFKVDG
KWHTRIDYQRFFELLEERGADGDWTPEEYMGPETPEWATWGNGGFDPRDVRVDRKGRKIE
TS
>A0A8C5P6M4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptobrachium leishanense|TrEMBL
MKWKMMGMQAFLCASLLHCVCADHVDADTSGTWDFIYTHLMLLWINRFCIYSCAAVGIAL
WICSHFISRKSKEPKYSSQNGSPVLQTEKLEKENHCSPKEIFVSGVKIFYGSQTGTAKGF
AHLLAEDITGLGLPTDIINLMEYDPDDHLAEETTSKNICVFLVATYTDGQPPKSAEWFCK
WLEEASNDFRYGKTFLKGMQYAVFGLGNSVYSNHYNTVGKNIDKWLWMLSASRIVTRAEG
DCNVVKSKHGSIEADFSAWKFKFLERLQALMEGETKACTGKRKKGTCKSMKTSSTEALAE
EENRADNSENEQTEEELYETTSESEPEEAGEGGSSGLIDVEDLGKAMRNMKKSKNVGSDP
GSPGKPVQSEEPREMITPALQKALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCVETTPSLACANKCVFCWRHHTNPVGTEWKWKMDQPEMILEEAIENHQNMIKQF
RGVPGVKADRFEEGMAVKHCALSLVGEPIMYPEISRFIRLLHEREISSFLVTNAQFPEEI
RCLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAW
NVDELRAYADLVTIGKPDFIEVKFKIDNEWWTWIDYEKFQYLIREFKKSGGRQKFTALDY
MAKTPEWALFGSKERGFDPVETRFQRKKTKDISGC
>A0A1V4TJC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. PtaB.Bin024|TrEMBL
MPLSDQALESLEKKGYRFVGTKRHAAAKVCHWTKKSLLDKGVCYKEKFYGIKSHRCLQMS
PSIPFCHHKCLFCWRDVSITNTTWNEEFDEPGEIIDECIQAQRKLLVGYFGNPRANQKKL
KEAQNPTNAAISLAGEPLLYPAIDELLEEYKKRHFTTFLVSNGLSPEKLTNMKIEPTQLY
LSLDAPNLEIYQNICDPQVKKGWENLNQSLELLSSFKCRTVIRITCVSGYNMTNPEEYAK
IISESNPDFVEIKAYMFVGSSRKRLKLDNMPKNDEVYRFAQSIAVLCGRKIVDHSPESRV
VLLA
>A0A6P3QJH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pteropus vampyrus|TrEMBL
MDPPLDTWDFSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQDKNSQEKSVPKTTQDL
MTNGYISLQKKEVFVSGIKIFYGSQTGTAKGFAADLAEAITSLDLPVAVIDLKEYDPDDH
LVEEVTSKSICVFLVATYTDGRPTESAEWFCQWLKEASTDFRFGKTYLKGMRYAVFGLGN
SAYVRHFNKVGKNVDKWLWMLGAHRIMTRGEGDCDVVKSKQGSIEADFRAWKTKFISQLQ
ILLKGEKKPCDGNCKKGKCKSNEHIAEEIEPGSHAQDGLHQRDTEEEEPFESTSEEEPDT
EDHQSLSSVVDVEDLGKIMNRVKKEKREREHKEEKTGLFRNTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKLMLCGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPDINRFLKLLHENKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
DKEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMAKTPHWALFGASERGFDPKDIRYQR
KNKSKDISGC
>A0A8B9VDN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anas zonorhyncha|TrEMBL
WICFFYISQRFAKGLAEAVISLNLPVEVISMGDYDPDDCLAEETTSRNICVFLVATYTDG
QPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNSVYVDHYNTVGRNIDRWLWML
SASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSCLQALCRGERKPCSGKCKKGKCKS
QGKQSKESSDHEHGASEDLGAELVETTSEEEADAEEVGGTNSVIDVEDLGNVMSHMKKAK
LEEGHVGTSLSGETAGRKEAGEKREMITAALRDALTKQGEVLSAWHTFYGIESHRCMEAT
PSLACANKCVFCWRYGCMVQGEVICNLCQFSVFFAGVAGVKADRFEEAMTAKHCALSLVG
EPIMYPEINRFLKLLHQHNISSFVSGLQQFGAEIPCWNLEPVTQLYVSVDASTKESLKRI
DRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELRAYADLVSLGKPDFIEVKG
VTYCGESSASSLTMANVPWHEEVVRFVQELVELIPDYEIACEHEHSNCLLIAHKKFKVDG
EWCTWINYERFQELVREHERSGGSKTFTAADYTARTPRWALFGSSQRGFDPLDVRYQRKS
KAKDISGC
>A0A497JEJ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Hydrothermarchaeota archaeon|TrEMBL
MIEMNEEVRKLLEKQGYRIVGNHSAVKLCHWLRERLLRKRPCYKSKFYGIATHRCLQMSP
SVAWCQHRCLFCWRPVEHTLGEEINVSLDEPSFIVEKSIEAQRSLLSGYWGEKRVDRKDM
EEAWNPKHAAISLAGEPTTYPYIDELIEEYHKHGFTTFLVTNGMHPERLEKVKPYQLYLS
LIGYDEESYKRICRPTIKDGWQRLMKSLEIFSGKKQRKVIRLTLVKGYNLEHAEKFAKLI
ELASPTFIEAKGYVHVGFSRQRLRRENMPTFDEVKEFAIALEKATGYKIKDYVEESKVVQ
LAK
>A0A2I0RTX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cercospora zeina|TrEMBL
MDTSRLLALPQELLLLYHAHRVEVLLSAGILVAIVRLLARWRSKKAKLLLTPPVGSPVQE
KPLQLADGKESASRSTPEAPPAESSKPKGPKRVQGVRTGKRKGGPVRATDQIQPYVFYYS
LGGSTRAYAEKLASTIEASERLLTPIIHDLTEIDYDDYFISAPKQARSGIAAFYYVLVPS
YNIDTELSNFLSHLEETHHDFRIDDQSLSGLAGYSVFGFGDRQEWPTEEEGYCSQAIEVD
RWMAKLTGKKRAYPLGTGDVKGDDADMRLDEWKRGVYSIMEDLGRGKGLGVGVPGSGDAA
ESADEISEDEDDSTLDPTPRRTTKRNTTDDLEDIKAPIPVDFTTTSTKRAPQPAVPKAMV
PKESPTYSSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMEATPSL
ACANKCVFCWRHGTNPVGTSWRWTVDPPDQIFQGMTAGHYQKIKQLRGVPGVRAERFAEG
MQIRHCALSLVGEPIFYPHINELLGMLHANHISSFLVCNAQHPEQLAALGPVTQLYVSID
ASNKDALRKIDRPLHRDYWERFTQCLDILHEKRHTHRTVFRLTLVKGFNIDDEAQGYADL
VQRALPAFVEVKGVTYCGTSTSKGAGLSMQNVPFYEEVQAFVLALERELQKRGLDYGIGA
EHAHSCCVLLADKTRFWRPLGAGQEHAIRTKYEGEGRYHTTIDYPAFFRCVERGGKFGPE
DYVAETPTAEWALWGNGGFDPRDERVDRKGRPKEVEEVKRVVEI
>A0A1B8GX30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus verrucosus|TrEMBL
MANNEYFGADIASHASENYFMALWHTYRIPLILTALALLLITRTVLHLKVGREKIVYTPP
PTPSEKAPLAANPQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLGYKPASKDVKFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLAPIAHDLAELEDYDEYFLGLPK
PEDDSQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAKERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEEAEDDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQDESEEQDEDEGAIDFTTYGKKNPKPTAAPKEMVPKGSPTYNALTKQGYTIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
GAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVEG
EEAEVKVETKPALVEI
>A0A0P4VT25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhodnius neglectus|TrEMBL
SDKEMMVRKDFMKNQFKESGIVPIKVLNVYYCTQYGSTKELCEKLRTLSTVKINIFDMGT
VEAEEVFLRDANAPHTISVIIIPTVGDGMPPDNGSWFCKWLSEAATDFRIDKELYKGLNY
AVFGLGDSAYGENFNIVAKKVDADLKKLGARRILPLTLGNENASNRINGSLADDFRTWLN
DLKELIKHSEISVSWLTQKVSNEDSSDEEVSDNDDVVDVEDLVIRSVKKESLEEKEMITP
PLRQILTKQGYKLIGTHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMEATPSLACAN
KCVFCWRHHSNPVGTEWKWKTDLPEDIVTGALKNHYNMIKEFKGVPGVLLPRFEEGLNAK
HCALSLVGEPIMYPSINKLIRLLHERQISTFLVTNAQFPEAIANLEPVTQLYVSVDASTE
ESLKKIDRPLFKDFWKRFLDSLKELSKKGQRTVYRLTLVKSWNFDEMQNYANLVDLGKPD
FIEVKGVTYCGGDNNGPNKLTMANVPWHEEVVSFVLQLTSLLKDYEIASEHEHSNCLLIA
HKKFFINGQWHTWIDYDRFQKLMKTYYKSDGKENFSTLDYTSPTPPWAVFGAEERGFDPV
EKRWYRKNKKDISGC
>A0A6J1CT11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Momordica charantia|TrEMBL
MSMSSLSARLTLLALLSASTFYFFYKSRRLRKLKLSLNPTVCSRRAKLFFISETGTSKAL
AHRLLNVLNSNELAFDLVDPEDYEPEDLFKESLVLLVASTWEDGGPPPHAKFFANWLSES
AEDFRVGSLLLSECKFGVFGVGSRAYGDTFNAVARGFSKQMRALGAKEILPVGEGDVDGG
DIDKCFDDWSQQVLKVLKVDAVGSGTDLYSAIAGDSDAESVEDDEEDADLGAEDIVDLED
IAGKAPSRKSTNVVETNGKLNGKKEMVTPVIRASLEKQGYKIIGTHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPLDIVNSA
IDLHTKMIKQMKGVPGVTQEKLAEGLSPRHCALSLVGEPIMYPEINTLVDELHRRRISTF
LVTNAQFPDKIKSLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKALNDKQQR
TVYRLTLVKGWNIEDIDAYSNLFSIGRPDFVEIKGVTYCGSSNTSKLTMENVPWHSDVKS
FSEALAAKSQGQYEVACEHVHSCCVLLAKTDKFRVNGQWFTWIDYEKFHDLVASGKPFDS
KDYMAPTPSWAVYGSDEGGFDPDQSRYRKERHHRPKPMSS
>A0A133VPU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA382N08|TrEMBL
MFLSSEEKKNLENGGYRLVGKHKHSAIEVCRWTKKSLLDEGVCYKQKFYENIHGNKSHRC
LQMTPSLPFCNNRCIFCWRNSEANSPSWEGEVDDPSDILNEAIEAQKKLLSGFKGNPKAN
KEKWREAQTPNLTAISLDGEPTLYPRISSLIEECRKQNITPFLVTNGQNPKVLEKMVEPD
QLYISASAPDEKTYVEACRPLVSDSWDNLNRSLETMASFSCVKVLRLTLVEKLNLKNPEG
YAELINKAEPDFVEPKGYVAVGHSRSRLGTSYMPTHRKIKKFARNLADLTGYSLVDEFEP
SRVALLKS
>A0A5N7DU71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus pseudonomiae|TrEMBL
MAEPFLTEGLVTLWHSYRLPILIAIASVAIILQAYRRFQPKSKAVTASSIPPSPRSQTPE
KFDQIRTGERETPAVAEKSAPKPAVRNDPAPKVVSGPKRVSGKKPLKVAGRRREDQEPPL
SFIQPIIFFASLTTTTERYAQILLEDLRTAAKERADPENRERGLLPPQIYDLSYIDFDDY
FTTAPKPPPTSPGTRYVYCLLIPTYNIDTVLNTFLSHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAESAFKEWSRGLQ
DIFFDILDNGGLGEGVPGSGDPLESDEEDLDDEENDGKGTKRRNGQDVVDLEDIKMGSDG
QTGSGPVPVDFTTVGKSAAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELI
FQGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLNMLHSER
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVVGYANLVEKALPCFIEIKGVTFCGTSTSAGVGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCALLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTPFRPEDYMRETEEWALWGNGGFDPNDQRVYTKGSKKGLHLAATK
>A0A843KVF4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolinea sp|TrEMBL
MHSEPCDALRRQGYQFFSTESSAALKPCLWCKRALRGGDMCYKHQFYGIESHRCVQMTPT
LRCNQRCLFCWRSFEHEYPGEREISPDEILASVRQLQKKALSGYKPSPYVTQERFAAALD
PKHVAISLSGEPTLYSRLPELIDLFSHEGFSTFLVSNGTRPDVLEQCRPFQTYISLTAPD
RETYLRVCRPLEDTWDAIQESLSLLGTRRSAVRITLVKGYNDHEPGAYGRMILESGATFA
EVKGYMFLGYSRKRLERGNMPSFAHVKEFAEKIAAEAGYRIRDENPLSRVVLLERVQ
>A0A2T7PHN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pomacea canaliculata|TrEMBL
MDDGDGGDVSATGGRYLCLAGACGLRFTAIDRVRWRNQPVVVGDDEGRKTKENEARMLEA
LFQRWGRVHVWSLALAAAGLAWIIYSVRQKSSNKATSDGEIPNNQGKNETETLQVSRKKP
SRRKRKLKIFYGTQTGKSKAFAQRLAAEVKAYGYNVELVDMKTYDPEENLAEEAVDGSVC
VFLVSTYTGGKPPEDTEWFFKWLEDTALDFRVQKTLLSGMCYAVFGLGNSLYKENFNVVG
RNLDSWLQELSAIPLVSMMTGDENTAESRNGGIEEDFLEWKKALWKMLKPALDGRKVKHC
KGDTCSKKCENCKSGKLGEAGDATHEHTKGGCSSDEEIQFETSSEEEEEERETEGMTNSG
LVDVEDLGKLMELAKTARTKEEKEMTQDNGEPREMITPLLRESLEKQGYRLIGSHSGVKL
CRWTKSMLRGRGGCYKHTFYGIESHRCVETTPSLACANKCVFCWRHHTNPVGTEWKWKMD
DPKTIFDGALKNHVNLVKQFKGVPGVKPERLAEALEPQHCALSLVGEPIMYPEINAFVTM
LHEKGISSFLVTNAQFPDAIRALLPVTQLYVSVDAATKESLKKIDRPLFRDYWERFLDSL
KALSEKQQRTVYRLTLVKGWNTEELDNYASLISIGNPDFIEVKGVTYCGESKASNLTMVN
VPWHEEVVDFVKQLAERLPEYELASEHEHSNCLLLANKRFKVDGEWWTWINYPKFHALIQ
QYTSSNGAATFASTDYMAKTPAWAVYGATEQGFDPVETRFYRKKQKDISGC
>A0A6J0LL53|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Raphanus sativus|TrEMBL
MNLTSMSSSSSIHARLALIALLSATTFYCIQKYRRLKLLKHNHLSSNLNPSTTRRGKIFF
ISQTGTSKSLAQRLRDLLASNGIAFDLVDPRSYEPEDLPKETLAIFIVSTWDGGKPPKDG
EFLVDWLSESAEDFRVGSLVLSGCRFAVFGVGGRAYGESYNAVGKELSRRMVGLGGVEMV
PMGEGDVDDGEMDGVFRDWCDGVIRVLKGGSAQETNEISQNGAVVSDGEYIDTTDEEEEE
EDSNDIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKI
CRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMD
DPKEIVKGALDLHTKMIKQMKGVPGVTAEKLQEGLTPRHCALSLVGEPIMYPEINALVDE
LHGKRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSL
KALQEKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMEN
VPWHADVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDL
VASGEAFTSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQVVVA
>A0A497RTR5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MIPPEVKKMLQHQHYHIVGEHSAVKLCHWTKKSILNRGYCYKQKFYGIQSHRCLQMTPAV
AWCTQRCLFCWRNVEQTIGTELERFDDPSKIVENSIMAQRQLLSGYGGIPDRINKKKFEE
AQNPNQVAISLSGEPTIYPRISDLIEEFNRRDFTTFLVTNGTLPERLESLDPLPTQLYLS
LDAPDEEIYKRVCNPIIPDGWRKINETLNLFPSLNTRRVIRLTAVKGLNMVGVEKYSNLI
RIAEPDFVEVKAYMFLGGSRRRLTLENMPSFDDVRRFSEELSEELGYGIKDQKEDSRVVL
LTRDSCNRKIK
>L9YRU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema pallidum DSM 3751|TrEMBL
MSDSANPGADGTSGDATAEGDGGGPAQVSSPEYHSENHTAAQTCGWTANALRGEGKCYKN
IFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVAWDDPEAVVDASIDLQKKLL
SGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRP
EMLRDCNPTQLYVSVDAPERHTFDQVVGAMEDDAWENLLETMHVLAEKDDTRTVLRTTLV
NGENMHNPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPEHEAVVAFAEDVREHM
PGFDEVMGVPASRVALISKTNDTWVPKLQKGSEFWERDPITGD
>A0A167KUN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phycomyces blakesleeanus (strain ATCC 8743b / DSM 1359 / FGSC 10004 / NBRC 33097 / NRRL 1555)|TrEMBL
IFYSGLTGTAKGFATQLEDQIKAVSEAVKVKQIQVLDITDYDNEDLLTETSVCVFVLSSY
NIEGPLDWFTKWLRDIRYDFRVDRIALNKLRYAVCGLGDSAYGDEFNVASQDIDKWLGQL
GATRIYPLGACDKNADQKTQFETWAHQFVSELQDSHSLEYAPTNIEYDSEGEEAEEAEGE
DGSPGSGDEMVDLEDMGNMAAKLKAAKQDPLNDQPKEVREMVSPMLHKSLTKQGYKIVGS
HSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTV
WRWKVDDPKFILDGAMENHYKMIKQLKGVPGVKAERFQEAKTIRHCALSLVGEPIFYPHI
NEFVTMLHERNISSFLVTNAQFPEAITNMVPITQLYVSVDAGTKESLKKIDRPLFRDFWE
RFLGSLESLAEKGQRTVYRLTLVKDHNTEEIDNYVDLIRRGKPSFIEVKGVTYCGYSGAS
NLTMANVPYHVEVVDFCKKVIAKLGSGYEISCEHAHSCSILIASTDFKVNGEWHTHIDYE
RFFALVKSGQPFTSLDYMAKTPDWAIFGTDEAGFDPEETRFYRKNRK
>A0A842MU49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MFIPSDKLLELEKAGYRFVGRNRHAAVKVCHWTRKSLLNRGFCYKQKFYGIQSHRCLQLA
PGLPFCDHSCIFCWRNTEVTSPRWEGGVDEPSEILDGAIAAQRLLISGFGGNPEVDKRKF
REALNPNHCAISLAGEPTLYPKINSLIEECRRRGMTSFLVSNGQHPEVLEKMEEPTQLYI
SLVAPDPEAYKKVCRPVLSDGWDRLMQSLEILSSFSCRRVIRLTLAKGLNFTDPQSYAKM
ISRTDADFVEVKAYMCVGYSRSRLGLENMPLHSEIVDFARAIAAGSGYNFSDEAELSRVA
LLSRG
>A0A8J8DKY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. LS2|TrEMBL
MENVKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKHNRVCYKQKFYGIHSHRCL
QMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQKKLLSGYWGVKDQI
NVKKLEEAMEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEELIKD
DKLPTQLYVSLTAPDIETYNRVNIPMIPDGWERIIKTLELMRDLPTRTVIRLTLVKDENM
HNPKGYAELIMKAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEELVKYLPGYHI
EDEYQPSRVVLIMRDDISKEERFIKH
>A0A341CYW5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neophocaena asiaeorientalis asiaeorientalis|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
TTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVNHFNKVGKNVDKWLWMLGAHRVMSRGDGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKREKREKERQEGETSLIRSTVKNEAGERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELIQEYEDSGGSKTFSAEDYMAKTPHWALFGASERGFDPKDTRYQRK
NKSKDISGC
>Q9YD53|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)|TrEMBL
MPEKWLPLAEVMVKQKYHFAGRHTVVKKCYWTHKALTEDRHCYKCKFYGIESHRDIQMSP
AAFWCWNACLHCWRIRPQDLGVDLDETKLTIVDDPKWLVDELIRIHRRLISGYKGHPRVD
PKKFWEAWNPVHVTLSLTGEPTLYPMLSDLLKEVHRRGMTSFLVTRGVRPDILADLEEEP
SQLYVSLEAWDKKSYNYFTRPLVPRAWELTMETLEMMPSFTSPTAIRITLVAGFNDTDEA
LKGFAKLINLAQPTYVEIKSYMWVGASRMRLSKANMAEHEYVRKVSERLSELTGYPILGE
SRASRVVLLSRLEKPIRLGKGCPEGLNTPEPEEGEYDAPYDPDIMP
>A0A7C5TJB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MEGGMNELKELEGIYYRQGYRIVGSHRHSAVKICEWTKEALRSRRYCFKQKWYGIQSHRC
LQCTTALYWCLNRCLYCWRSFKGMKVLPGDDVKWDEPEILLDEMVEAQRSLLIGFRGNPR
VDRSMLEEAFNPTNVAISLIGESLLYPYLSDFIELTKHRNMTSFLVTKGTTPDELQRLSS
HPTNLYISLCSPDEDTFRKLETPLVPDGWSRVLRSLELFSTFVNSRRVIRITLVKGWNMD
NIDGYAKLIEKANPDFIEPKAYMWVGESTRRLARDAMPTLEDVIGFADKLARATGYRFVD
IFEPSRVALLGR
>A0A497MTZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MDVPESFREILIKQGYRLVGKHSGVKVCEWTRRSLTRGEYCYKQKWYGIESHRCLQCSLA
LFWCLNRCLYCWRSFKLFLGAEMKVEPDDPEWILEGLIEAQRTLLVGYKGNPKVPRWKWE
EAQNPTNLAISLIGESVLYKRLPEFIAIAKERGMNTFLVTKGTYPEMLKKLEVEPTNLYI
SLCAPDKETFESLDRPITPDGWEKQMESLELMRSFSCRKVIRITLVKGYNMHGIDGYARL
IAKAEPDYIEPKAYMWVGESRKRLPGDAMPTHEDVIEFARRLAEETGYRFADFFKPSRVA
LLSAK
>A0A7J3XTJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLPPYIKSLFVKQRYHLIGEREHAAVKKCHWLHKALVEGSFCYKSWYGIQSHRCIQFTPM
LFCPNACLHCWRLERGDVEGWDEPAVEAFDSPEALLQGAIREQLRIVSGYKSNPKVDRRR
LEEARHPKHFAISLAGEPTLYPMVGDLVALLKSKGFTTFLVTNGLYPKALANLSYEPSQL
YVSVNAPSEELYRKVCRPALSNAWGRLMETLDLLRSFKCPTALRITLIKGVNDVEPEGYA
KLIERAAPFYVEVKAYMYLGFSRRRLELEAMPRHSEVADFAKSLERLTGYTFLADSLHSR
VALLSRVGQPLKVSP
>A0A7C3UF00|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSSNVLGVDVQTEGFRGFFKLLKRQKYQLLGGGAAVKKCRWLHKSLTVGKGCYKQKFYGV
ESHRCVQMTPTLRCNLKCRFCWRAHPSDVGLNEKGWVLVSRETLDAESIVKRSLEAQRKI
LSGYKSQVLSGRIERKKYEEALSPRHVAISLDGEPTLWHDLDGLIEAYRRAGLTTFLVTN
GTRPDVLKNLGREPTQLYISLYAPNEKVFKNVCLPSSLSLWRDVLSSLSLLQSFKCPTVV
RLTLVKDLNLLDPKGYGKIVEDAEPTYVEAKAYMYVGFSRMRLAFNNMPSHEDVKRFAEE
VSKETGYRIVDECLESRVVLMSKLDKPIKLNQPISYVNSQV
>A0A843AAL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fervidicoccus fontis|TrEMBL
MNVIEKKENVYDVLSEVMKKQGYHFVDSHTTLKTCSWTRNALTQRRFCYKCKFYGIESHR
CIQMSPAAFWCWNACVHCWRLRPSDTGLKWNEVKMPDYNDDVKRVVDRLIEEQRKMLSGY
KDHKNVDKKMFEEAMDPKHVAISLTGEPTLYNKLEDLIMEFHRRGMTTFLVTRGVRPDVI
LNLKEKPSQLYISMEAYNKEMYEWLNQPLVPNAWELTMETLKGLPEYGRPTVLRITLMKG
INMDEKAINGFAKIVEIMQPTYIEPKGYMYVGASMLRLSRDNMPTHDEVRKFAEELSKAT
GYPIRSESKPSRIVLLSKLDKPIRFGKGCPEGWNSEY
>A0A5J5LHN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula hispanica|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRGTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>B8MEQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)|TrEMBL
MADSSFVQALLETWHNHRIPIIFFLGVLYVSIRWPILYRRAKRQSSSTLPPSPRLESAIP
REKVDAPILDHLSVTTVDKPTSKLGPKRVVGNKDRRASRHPQKAGAASGPSFIKPVIFFA
SLTASTEAHARWLSEQLRAAAQEKSSGSNQEWGLLPPEIYDLSEIDFEDHFISAPKPPPN
SPNTRYVYCFLIPTYNIDTIIDTFLAHLDETHNDFRIDTAPLSNLAGYSVFGFGDKEGWP
TEDEGFCSQAKELDRWMAKLTGKKRAYPLGLGDSKSDGVNALKDWTSGLTEILLEIAETG
GLGEGVAGSGDPLESDEESAAEDEGETSRKKKQTIVDLEDINFAGGAKKRKGDPLPVDFT
TVSKAGNSQPVLKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYS
FYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNGVKEGHYKKIK
MLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHNEQISSFLVCNAQHPD
QLATLNRVTQLYVSIDASNRDSLRRIDRPLHRDFWERFQRCLDILREKRHVQRTVFRLTL
VKGFNVEDEVKGYADLVEKGLPCFIEVKGVTYCGTSSSAGAGLTMRNVPYYEEVIAFVVA
LKDELERRGLGYGIGAEHAHSCCILLASERFHVDGKWHTRIDYDRFFELLEKEKTEGISF
RPEDYMRETEEWALWGNGGFDPNDQRVRTKGKNKDRSIEQVTPV
>A0A2D7W6U2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIANRLSKQKYHLVGEHGGVKVCHWTKQSLVNDRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSETLNRIDDDPYELFLQSVKAHRRLITGYGGNPKADPKKFAEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDPLPTQLYVSVDAP
NKKLFNSLCKPKFDSAAFEKLEQTLELLPSLDTRTVCRHTLIKNESLGYHEDYARLDNLA
DPDFIEAKGYVYVGNSQNNLSIENMPTHQEVLDFSHKLAPLVGREVLSERSESRVTLIGK
EMIPVTLPKKIRDLPRDLGIAKPQKLNLPQI
>A0A2E5ZC49|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIASKLAKQRYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYQLYLESVRAHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIEELDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFHKLEXTLELLPSLDTRTVCRHTLIKNESLGFHEDYARLDNIA
DPDFIEAKGYVFVGNSRNNLSIDNMPSHADVMEFSETLAPMVGREVLSDRRESRVALIGR
EMIPVTLPDKVRDLPADLGIAKPMKLSLPQA
>A0A850TL56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Grus americana|TrEMBL
LDVSMDMWSIFSTCLVSTWLRRFYIYSAVAFGISIWIVVRFFTTKKKGEKSNGNPAASEG
REDKLVNGYATLQAKEVCVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDYD
PDDCLAEETTGRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKMYLKGLRYAVF
GLGNSVYVDHYNTVGRNMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
SRLQALCRGEKKPCSGKCKKGKCKSAGKQSKESRDHDHGASEYEDTEAEELFETSSEEEA
ADAEETSSVIDVEDLGNIMSHMKKAKDYKNARIHVWALASVLSLVDPWLNCATVFKTQCL
NLNVVIYCYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTAWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINRFVKLLHQRSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKF
KINGEWCTWINYGRFQELVQEHERSGGSKTFTAADYTAKTPRWALFGSRERGFDPSDVRY
QRKNKARDLSGC
>A0A2E0NCR2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDERLKARLQNQRYHLVGEHGGVKVCHWTKESLLRDRMCYKGKFYGVESHNCLQMSPVVD
QCNLACSYCWREPHMDTLELTDQDPLELLHESVRAQRRLLSGFGGNDKVNKEKLADAQNP
KHVAISLNGEPTLYRRLGEYIDECHKHGMTTMLVTNGTLPKVLEKLDPLPTQLYVSADAP
NKEVFDRICKPKWNSGAWHKFEETIDLLPSLDTRIVVRHTLIKDENMFGYEEEYAKIDER
AEPNWIEAKGYVHVGHSQNNLDITNMPYHDEILEFSNTLANLTGLEVLDDSKPSRVALIG
KEKIPLPIPEIVKEFPKDLGIAPPTKHLPLV
>A0A816Z1X9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica napus|TrEMBL
MASSSSSIHSRLALIALLSATTFYCIHKYRRLKRLKTLSSKLNPSAATIRGKIFFISQTG
TSKALAQRLRDLLASNGVAFDLVDPRSYEPEDLPKETVAIFVASTWEGGKPPKDGEFLVE
WLSESAEDFRVGSLILSGCRFAVFGVGSRAYGEAYNAVGKELARRMVGLGGVEMVPVGEG
DVDDGEMDGVFRDWCDGVIRVLKGGSAREGAEILQNGDVGLVSDGEYVDSTDDEEEEEGN
GDIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPK
EIVKGALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHG
KRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKAL
QEKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPW
HADVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVAS
GEPFTSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQAVLA
>A0A8J8A4W7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. LS1|TrEMBL
MAITFKSNPNMPEEIARLFQKQHYALVGHHSAVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGIELPQPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTAPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKILRTLELMNGLQTRTVIRLTLVKGE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVRHLPGY
HIEDEYEPSRVVLIMRDDVGKTERFIKH
>A0A7J6K3T6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARSRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIGDERATGEGNDIDTKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKVRGKAKPEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGEYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A6P8H8V5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Actinia tenebrosa|TrEMBL
MIFKPVMGVVAGILGIWLWTTLKAKQDEEKLPKTRDPNQADKLTTSAIKIFYGTQTGTAK
KFAEMLQELSTRQGTDCSVTSLKDYEPEDNLPNESCTCVFIVSTYTDGQPPEDAVWFCKW
LEESSNDFRVQKSLLGGVKYAVFGLGNSLYKDNFNMVAKNIDQWMTALSAQPAVPLRLGD
ENHINSKHGGIEADFEAWTKELLATFKSTSSCECGSQETCCKDEKNPQPLLKDSDEDAMY
ESSTDEDNDDESDKNRKKDPKSSGMVDLEDLGPALRKMKKAKEMENGSLVNEPKEMVTTV
IRESLTKQGYKIIGSHSGVKICRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWKWQMNEPEMIVDGAMQNHFNMIKQFRGVPGVKLEKFEEAMKIKH
CALSLVGEPIMYPKINELIKLLHGHEISTFLVTNAQFPDAIKNLVPVTQLYVSVDASTKE
SLKKIDRPLFRDFWPRFLDSLKALSDKGQRTVYRLTLVKSWNTDELKSYADLVALGKPDF
IEVKGVTYCGESKASTLTMANVPWHQEVVGFVQQLVALLPDYELACEHEHSNCLLIAHKK
FNIDGDWHTWIDYSKFHELIRDYEDSEGKASFSSLDYMAKTPNWAVFGDEHRGFDPDETR
WYRKNRKDISGC
>A0A832C4R0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylicus sp|TrEMBL
MVVLVEGPFRTLRAQGYQIVGRHSAVKTCHWVRKALTEGKICYKGRFYGIETHRCLQMSP
AVVYCTNRCVYCWRPLPGERGFEWVGGRIPAEDEPKEIVDGAVEAHRRALSGYKGNLKVP
EERYEEAIRPRHVAISLSGEPTLYSRLSELIEEFHRRGMTTFLVTNGTNPKALEELREPT
QLYVSVSAPSEGVYRRVCRPGDEGNWESLMRTVSMLKTFKCPTVVRITLVKGLNMEDPDG
YARVLNMGNPTYVEVKAYMHVGSSIWRLGAEAMPSHEEVLEFAGEVAKRSGYDLIDDVPA
SRVALLSRAPRRVQFCEDRRYSLRDKQNA
>A0A7C4CZB9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylicus sp|TrEMBL
MQVFKILKKQGYQIVGKHSGVKTCHWVRKALISNTICYKGKFYGIKTHRCLQMSPSVIFC
TNRCIYCWRILPGEGGIQWEGTRILEEDDPKFIIENAIEAHRRALSGYKGNPKVIKEKIE
EAMNPKHVAISLSGEPTLYSRISELIEEFKKREMTTFLVTNGTIPEVLEKIIEPTQLYIS
ISAPSKHIYNKVCRPVYEENWDKLMKSISMIKSFNCPTVIRITLVKGLNMEDPEGYANII
KNGRPKYVEVKAYMHVGYSIWRLGVEAMPNHNEVLQFAKLIAKHSGYEIIDEVPASRVVL
LTGD
>A0A1G9VEI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarchaeobius iranensis|TrEMBL
MSESDGPMQVDDPDYHSVNHTAAQTCGWTKNALTGDGKCYKYAFYGIESHRCMQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPAAVADATLELQRELLAGYGGNDEVPREVFEQAM
EPRHVAISLDGEPTLYPYLPELIDEFHARDITTFLVSNGTAPEMLARCDPTQLYVSVDAP
DRHTFDNVVKAVEDDAWERLVDTMDVLAAKDETRTVLRTTLVNGENMRDPDWYAAFYRRA
RPDFVELKAYMHVGHSRGRLDRSAMPDHEDVLAFAEDVAAHMPEHDEIKDVPSSRVALLA
RDADTWVPKLRKDSEFWAQDPLVDY
>L9ZAC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema gari JCM 14663|TrEMBL
MSDSANPGADGATRDAAEADGGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNI
FYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVAWDDPEAVVDASIDLQKKLLS
GFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPE
MLRDCDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMHVLAEKDDTRTVLRTTLVK
GENMHNPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPEHDEVIEFAEEIRDHMP
GFDEVMGVPASRVALLSQTKDTWVPKLQKGSEFWERDPVTGD
>A0A2B7XMC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blastomyces parvus|TrEMBL
MAGEDVEIAAQGLLALWHRYRAPILLLAAVVFTAVRLALRNYKRNTPQPDSLTASQNKSK
NQNAKSELESFPNNDPAPAGLSNRDRSRSSSVDSRSKQAKQPANGPKRVRGIKPTKNGAK
HQTGGGGLPQDIVIQPLVFYASLTGATETYAKSFCDRLQKTAQSLLENNNSKSNLLTPEL
LDLSYIELDDFFITAPKPPDAPNIRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRIDTS
ALSGLAGYSVFGFGDREGWPTEQEGFCSQAKEVDRWMAKLTGKKRAYPLGMVDVKGDNTQ
KVLNEWCDGLTDVIVDLMTAGGLGEGVPGSGDPVESDEEDIDDDGEESDETGENRRNKGK
KEQIVDLEDINFGGSNSRKASANPQPLPVDFTTQSRAQVSKPVSKLEMVPTSSPTYAALT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWR
HGTNPVGTTWRWKVDPPDLIFDGVKTGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLV
GEPIFYPHINEFLALLHNERISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKID
RPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCFVEV
KGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELARRGLGYGIAAEHKHSCCVLLA
SNRFYVNDRWHTRIDYDKFFTLLDKEKNDGTSFRPEDYMRETEEWALWGNGGFDPNDTRV
YTRGRNKAKLNAALKESQETTVSAEG
>A0A0L1IFD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum IGH-CR14|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDTSNTNDTNN
TNIMNNTNNTNIMNNTNNTNIMNNTNNTNIMNYTNNIRTGENCVSESETSSNQSYPDDED
EQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTF
YGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKE
LKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPQE
LENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKE
YNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINK
KKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVE
TPHWAIYGSQESGFSPYFFHHHHYLLIIYPHEIPKLICPYRNISSSFAPPGKKKKKKKKK
KKKNIHIYVYIYIYI
>A0A7K4MJV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote|TrEMBL
MSCSAETVEEDDRLIQIKPAIAKQLKKAKYGIADHATVALCHWTKKSFKHEGNCYKHKFY
GISTHGCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPKQVAEPEAILTKLMIERKELIN
GYYGDSRNDKQRLDESLLPSHYSISLSGEPTMYPKLPELIKYLHSLKATKSTFLVTNGQE
PDMIQRLQDEEALPTQLYLSTNAADYESFKRINQPKYDDSWERWNRTLAMLKHLNTRTVL
RITLIRGYNDIKEMIPAFAEMVRKASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEIKNFS
EQVAKQSKIFSIMDESFVSRISVLQNNERLIDRYIPTCVNTN
>A0A522ET06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanoarchaeota archaeon|TrEMBL
MDANYKEALKKQGYVFIGEHSAVKTCAYTGKSLAGKGNCYKQKFYGIQSHRCVQMSVAVN
FCNLDCTFCWRERNNSAFGKIDDPVRLADNAIAAQRRLLSGFGGNPSTPKEKWAESKEPL
HFAISLNGENTAYPRLGEFIAELKRRGHSTFLVTNGQLPEILRKMEREGQLPTQIYISMS
APTEETFKTVDRPLYKDGWERLKKSLQWLSTVSSKTRTVVRLTIIKGVTSQHIKEYAELV
KIASPTYLEVKSYMYLGASKARFERKNMNSHADVLEFCNQLAPLAGYKIIDDQEISRVAL
MMKEDRVDRLMEFPQSLPLFEKDSKRFDVPFKGYMEIQDVESCDGCTSDETIEVPIAHLI
QASPPELAQKEELLKIKL
>A0A6G1GWG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aulographum hederae CBS 113979|TrEMBL
MCTILEKDSEFAEQGDVSTARCGKESSNPNSFAQLYNHTTDQLQPHVFFASLTGTTEKIA
QDLVQKLPGWEQNRPSVPSHIRKPILHDLSYTELDDYFINPPRSDSNVHAFYIILLPTYN
IDTILDNFVEHLKETHHDFRIDNAPLRNILGYSIFGFGDKEGWPTEEEGFCSQAREVDKW
MAKLTARKRAYPLGVGDSKSDANVRLEEWREGVSAVIREIAAGNGLGEGVPGSGAAVESD
EESEDDLSATEEDDTVPVKLAKKKKAGSTLSDLEDLGRMINKGSERDIEKQSGPIPPAVD
FTTYKKSLKPKDPAALKEMVPKESPTYNALTKQGYTIVGSHSGVKICRWTKSALRGRGSC
YKFSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWRVDPPEEIFQGVTDGHY
RKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEFTDLLHKQHISSFLVCNA
QHPDQLEALQHVTQLYVSIDASNKESLRKIDRPLHRDYWERFQRCLDILREKRFIQRTVF
RLTLVKGFNIEDEVEGYADLVQRGLPCFVEVKGVTYCGTTTSSAGLSMQNVPFYEEVSAF
VVALNAALQRRGLDYGIAAEHAHSCCVLIASTRFRNSEGQWCTLIDYDAFFKCLESGKEF
TPEDYMGTPTPEWALWGNGGFDPRDERVDRKGRKKVEASVDE
>A0A834TYJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Senna tora|TrEMBL
MPLSSVPARLTLLALFSVTTFYCLYKSRRLRHLKLSLYPKPSLPSTRGKILFVSQTGTSK
ALAQRLHQLLTSNDLAFDLIDPKDYEPEDLPKETLVLIVASTWEDGKPPPSAKFFATWLA
ESAKDFRVGSLLLSKCRFSVFGVGSRAYGATFNAVARDFARQMKALGASEILPVWEGDVD
GGDVDGVFDLWCAKIAGFLKGTVLENGGVSESSFGGECNAPSLEESEEDSDGENDMKSEI
VDLEDIAGKAPSRKSVPVVETNGKLDGQREMVTPVIRANLEKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPVE
IVNSAIDLHSNMIKQMKGVPGVTLERLFEGLSPRHCALSLVGEPIMYPEINILVDELHKR
RISTFLVTNAQFPEKIKLLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALR
EKEQRTVYRLTLVKGWNTEDVDAYFKLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWH
ADVKAFSEALALQSQGEYEVACEHVHSCCVLLAKTDKFKIDGQWYTWIDYEKFHDLVASG
RPFTSKDYMAATPSWAVYGADEGGFDPAQLRYRKERHHKSSR
>A0A1V5ARJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosaeta sp. PtaU1.Bin060|TrEMBL
MDETLAELTNPIRAASRQRRHKPIQSMDKRETAEKALAKQGYHLVGSGAVKPCLWLNRAM
RGGEQCYKHHFYGISSHRCVQMTPTLECNHLCLHCWRPIDDPVSRQAGWTEPDELLNGIL
HEQQRILSGYGGAETTDMSRLKEARSPKHVAVSLMGEPTLYPHLRELIELISKKGMTSFV
VSNGTRPEMLERLRPTQLYISLNASDEALYRRVSQPSGNLWPKVQESLALLREHTCRSVV
RMTLARGLNLQSPEDYARILAKAEPDFVEVKAYMHLGRSRMRLNRDAMPQHTEIFDFAKL
LAEAMGYELAAEVPLSRVVLLSSGRIRRSIT
>A0A1Z5K4H5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fistulifera solaris|TrEMBL
MNMSQAQRNQSAAIAAALLGGGITVAWYYSRYLRPTIETPLESSPDVPIREVDCSQSQTT
KEDTKLRILSPGTISIVHASITGTCEKLARQLYTELSLLTTSNRVVQVGSVQEWDWWDEL
LNEDDEDDVKGSRAPLPVLILLLPTYTNGTWPPFAADTLERTLQDVQHDWRVQSLPLKNK
LQVAIFGMGSSEYDDTMGRPARECVRHFQKLGAKCLLRLKVGDDAVGDHAKETFHQWNME
LQRKLKVGKKEVETKDLTKNGGCACGEESKPNGGCHKHAEEPLEVMEERAEYESDDEDEE
DVEEPTVMDLEDMGNAMASEKKQVGNGEPREMVTPRQAQQLKKEGYKLIGTHSAVKLCRW
TKHQLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGKEWRWKTDDPQ
FIVEQAVQTHVNMIKETKGIPGVQMDRWKEAHTVRHCALSLVGEPIMYPRINEFLSELHH
REISTFLVTNGQHPQAIESLLPITQLYVSVDAPTKESLIAIDRPLFQDAWDRLKQSLVSL
KNKGQRTVARLTVVKGWNSDEVSGYAKLIALGHVSLVEIKGVTFCGKSDASNLNMSNSPW
HHEVVDLAKTLQAELNRIRETDNAVPQYDLACEHKHSCSVLLARVDQFLEISPEGERQWH
TWINYPKFQELAARHEADPSFTFHVKDYTAPTPEWALFGAEEEGFDPTDTRHRKATKQPK
YTQYDDRGIPTHDHTGQPLAEEERQRLFELMEARMREIGTGSTVTELRGGAKEIQDASLM
FRGLVVSI
>A0A6P5FFS6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ananas comosus|TrEMBL
MTDASLSSLPPRLASAFFLFKSLRLRRLRISAPSPANPNPKIFFASHTGTSETLARRLSH
RLRSLGLPFDLVDPKHYEPEDLPKETLVLIVASTWEEGRPPPNAEFLARWLAESAEDFRV
GSLLLSRCRFAVFGVGSGAYGEAFNAAARDFSQWMRSLGATEMLPVSEGDVDGGDVDEVF
DAWSEKVIGLLKEKEEEGNGKVIGLLKEKEEEGNGELLGSGVESDASDGMEEESEEEADV
EDSNEVDMEDIAGKAPSRKSSVTLVNGKSSGTLVNGKGDGLREMVTPIIRTSLEKQGYKI
IGSHSGVKLCRWTKSQLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHANPV
GKSWRWKMDDPLEIVDAAIDQHTKMIKQMKGVPGVKQERLDEGLSPRHCALSLVGEPIMY
PEINTLIDELHQRRISTFLVTNAQFPDRIKMLKPITQLYVSVDASTKESLKAIDRPLFGD
FWERFLDSLKALHDKEQRTVYRLTLVKGWNAEEIDAYANLLTMGKPDLVEIKGVTYCGSS
ATSKLTMENVPWHSDVKAFSEALAVKSNGIYEVACEHVHSCCVLLAKVDKFKVDGKWYTW
IDYERFQELVASGTPFRTEDYTALTPSWAVYGAEEGGFDPGQSRYKKERRHGARS
>A0A849R391|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MEPKAISNYHEATLEKQGYHFVAPHKHSAVKTCLWLRRSIRAEGNCYKGKFYGISAHRCV
QMTPCIFCNQRCIHCWRPLEAFNMGEEAVAWDTPLEIVEGCIKEQRRLISGFKGSSKTSK
TAFAEAEEPKHAAISLIGEPTLYPHLQELTQEFHSHGMTTFVVTNGTNPAVLREIHPSQL
YISLNAPDEAIYKRVAHADYWAQIQESLEVMKGMKERTVIRITAMAGTNMVDPGGYAKLL
ETANPDFVEVKAYMHIGYSRKRLTRDVMPSHTEVKKFAGEIAEHLTASGGNYKIVDESEI
SRVVLISNLSSEVKALPKL
>A0A0F8SCN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 1.H.T.1A.1|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPSMLAKINPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDFMK
EKSSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISCLD
>F9CY40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosarchaeum koreense MY1|TrEMBL
MSCSGEIVDEEKLIQIKPGILQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVSEPKEILTKLMEERKKLIMG
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEP
DMIQRLQDKDALPTQLYLSTNAADYDSFLKINRPKYDDSWQRWNRTLEMLKHLDTRTVLR
ITLIRNYNDQKEMIPAFAAMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVRRFSE
EVAKHSEIFSIMDESLVSRIVILQNNQRSINRWISAYSNTN
>A0A2H6H1H8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon BMS3Abin17|TrEMBL
MIPEKVKKVLKRQHYEIVGKHSAVQTCRWTKKSLIDEGICYKEKFYGIKSHLCCQMTPSV
MWCPNKCLHCWRAIELTLGDKLERDTDSPKEIIDGCIKAQRKLLQGFKVDKHSKKKQLSK
ANQDKYIEAQEPMQFAISLSGEPTIYRKIGELISELRKRGKTSFLVTNGLYPEKIKELVD
KNQLPTQLYVSINTPNKKLYQKFHRSSKKDAWERLNKTLEIMSKLKNKTRTVARINLVKN
LNMIEPENYAKLIKKAKPLFVEIKGFMSVGFARERLGYDKMPYHEDIVAFSKKIIKELKK
LKQDYKLLDEHYFSRVVVLGKSKKDLKIKKKEF
>A0A6A6LHD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hevea brasiliensis|TrEMBL
MSLSSAYARLTLLALLSASTFYCFYKSRRLKLLKISLNPKDNLNANPISSSNKGKLFFIS
QTGTSKTLAQRLHNLFKLNDLLFDLIDIKDYEPEDLSKETVVIIIASTWEDGKPPSNASF
FANWLADSADDFRVGSLLLSKCKFAVFGVGSTAYGGTFNAVAKDFSRRLRELGANEIVEV
GKGDVDGGELDGIFDQWSGKVLRILKGGSMQNGLVFSNGCTGGESDNENIEDGFESEDDE
NGDVESGIVDLEDIAGKGPSRRSNTVAEVNGKANGQKEMGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKNWQWKMDDPLEIVNS
AIDQHTKMIKQMKGVPGVTQERLTEGLSPRHCALSLVGEPIMYPEINKLVDELHRRQIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKSLKEKQQ
RTVYRLTLVKGWNTEDVDAYFNLFKIGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVK
AFSEALALKSKGEYEVACEHAHSCCVLLAKTEKFKVASGKPFNSMDYMAATPSWAVYGAQ
EGGFDPDQSRYRKERHHRSSH
>M3K4H0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida maltosa (strain Xu316)|TrEMBL
MGSGNYIFGICSLFYLLSGGRWTLVLLAFVIYAFSQQPHREPDAIPPQQTKQVKESPVYA
VDFTSTSFTPSSTTVLPKTTIRTRAKRSPKIIKAANGKSKSPTEPVLTRSTVDLTKSQIY
IFYTTLTGSSQRIAKSLHEKLSNMESLEKTPKLMSLDDDVDDLEEYFLKVPQENAIYLLV
LPSYETDSPIDYFLEHLIDTFQDFRVDKYPLRKINGFSVLGLGDSESWGGDKFCYQSKLA
DKWLGKLGARRLYPLGQVCMKYEGDPKAQEWIQNFASLLDNDEPFYIDENDEVDDSDAED
GSADDADTLVDVEDMGDIIRKSGKSAGITTETKQMVAKDSPTFKSLTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRW
ELDPPEKVMQGALEGHYQKIKQMRGVPGIQMDRFEEAFRVRHCALSLVGEPIFYPHINEF
VGMLHEQHISSFLVCNAQHPDALARLAKVTQLYVSIDAPTKKDLKKVDRPLNSDFWERLM
SCLDILRTVQSHQRTVFRLTLVKGFNMEDIESYAEMVERARPSQIEIKGATFCGSSNGNG
NPLTMQNIPFYEECKNFVEKLNKELQNRGLDYDIAAEHAHSCCILVADQKFKINGKWHTH
IDYPKFFELLESGKDFVDLDYVKETPEWAVWGSEGAGFNPEDTKYDRKAEKLKKKIAREE
QLQKVLNSENV
>A0A7L0LL84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sylvietta virens|TrEMBL
LGVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRAKRKVTEPGRADKLG
NGCAPPQAQDVHVAGVKIFYGSQTGTAKTFSKTLAEAVTSLNLPVEVINMGDYDPEDGLA
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSLLQGLRYAVFGLGNSA
YVDHYNTVGRRVDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQAF
HKGEKKPCSGKCKKGKCKSSGKQNKESSDREHGTSEHENTEAEELFETSSEEEVGGTDSV
IDVEDLGNIMGHMKKAKREQELQEGAAGAGRKEESERREMITPGLREALTKQGYKLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEW
WWKMDQPEVILQEAIEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHIN
RFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQR
FLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASS
LTMANVPWHGEVVSFVRELARLLPEYGIACEHEHSNCLLLAHSKVSLPPHTW
>A0A8C7YB17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias sinensis|TrEMBL
AAPQTGSSLSENYLALLWHHRLYLYAAAALVVGLWVSLKVALSRVSGGPSLMALEDFGSV
AAACIVTCLTIMACAQGFAKVLSEELKALGFPAEVIDMKDYDPDDRLADECVSGSVCVFL
VATYTDGQPTESAEWFCKWLEDASTDFRYGRTYLKGLRYAVFGLGNSVYVGHYNTVCKNV
DKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQADFQAWKGKFLSRLQALATGEKKTCSGKN
CKTGSSCKSKKEEEEASKETGSEVRRREEGVLLTVTELGKNGPQLDGEVVKFSKLNGVKK
IDDDDGERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIES
HRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQDMIRQFRGVP
GVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLE
PVTQLYVSVDASTKESLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEE
MQAYAELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAAMLPEYEVA
CEHEHSNCLLIAHKKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDYMARTPSWA
LFGAREQGFDPADTRFQRRNKTKDISGC
>A0A814AFH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFKSSPKS
ASSKKIIPLENNGVTIVFGSVKGNSRTFAQSTYDKLSKDLNRQVIIQDFNDVTDPEEFLQ
TQAKNQRTLLVFIPTYEDATPPPSAKWFLLHLQEAATDFRVSKGELEKLTYAIFGCGNSL
YFENFNKVGKEVDRCLSELGAKRLLPTELADENTAKSIYGGQEGHYSKWSSKLKSALETP
KTEKCDCSNDTSTTTCCKTVTNGDHSIKNDDNNNDDDEEEPRIESDDDDEAGGCKDGNDD
IIDLEDMGEYMENSSPTKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAKTVTQG
AIDNHYKMINTFKGVPGVLPARLAEGMKIRHCALSLVGEPIMYPHINELIEILHSKQISS
FLVTNAQFPDEIKTLQPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKGQ
RTVYRLTLVKGFNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASSLTMANVPWHEEVV
TFVQALCERLPQYEVACEHEHSNCLLLANTVDVINIHSMELKVIVVWKLHQVLHVQINVF
FAGDIIQIQSVHHGNGKQMMLKL
>A0A7C1I3S8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MPAGSSDFRSLLPHNRKSVDAFACLRSFGRQHILGQKLVFYAHPGGGGVDVTITKAEFEK
KKYRFHGNSAVQICTWSKKALKGGGECYKQKFYGVPTHRCMQFSPSALFCQNHCIYCWRP
AEYLGLPHEVQWDAPAGMVEALVSHRVKLLEGFGGNPKAGPELYREALEPVHFAISLSGE
PTLYSQLPELVTYLRKRPKTFSVFIVTNGQEPDMLKQLQAKHSLPTQLYLSLSAHTKEAY
RKIVNPGYADGWKRMMASLHFLSKVPTRTVLRITLIKGMNMDLPKDWAGLIWLANPHFVE
FKAYTFIGHSRQRMQDINVPTLDEVRDFASEVAGHLHDQFETMDEDGPSRIVVMRNTRRT
TERLIKGPDPTQNGF
>A0A1U7YS43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nicotiana sylvestris|TrEMBL
MSPSLSSYPTRLAILTLLSATTVYFFYKSRRHLFKRLTSLNPNPKTPKGKIFFISQTGTS
KTLAKNLHSLLNLNGFDFDLVDPKDYEPEDLHKESFVLIIASTWENGKPPSNAGFFIDWL
NESVDDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVARDFSKKLRKLGGVEVLAVGEGDV
DEGNLDEVFGEWSKRVIGVLSNLGENGGYMVNGVGDGSEDEVVSEGDDDDDEEDDDEFEE
NDEESGIVDLEDIAGKGPSRKKGVGDKLVNGKLNGDIVNGEKEMVTPVIRASLVKQGYKI
IGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GKSWTWKMDDPLEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMY
PEINSLVDELHKRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPLFGD
FWERFLDSLKALKEKEQRTVYRLTLVKGWNAEEVDAYFNLFSIGKPDFIEIKGVTYCGSS
ATSKLTMENVPWHSDVKEFSEALAKKSNGGYEVACEHVHSCCVLLAKVDKFKIDGQWYTW
IDYEKFHDLVASGKPFTSKDYMAPTPSWAVYGAEEGGFDPEQLRYKKERRHKSSRKENGS
>A0A7J3B9C4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MISWGRVTIDEETLLRYKKAQYGIVGRHSAVQICSWTKKALRGKGVCYKQKFYGIDCHRC
AQMSPAFAWCQECCVHCWRPAEWMKKIRINENDLDEPALIIDGVVKERRKLLCGIGGAKD
VDKEKFLESIKRFPSHWAISLSGEPTIYPKIGELIELLRKNKEVRSVFLVTNGQEPDVLK
GLKAKKLPTQLYLSISAPNEKLFKRLNRSVYLDGWERLQESIGTLRSLKCRTVIRLTLIR
GVNDMSEHLPEYAAILERSKADFIEIKSYMYIGLSRNRLKEENMAPHSYVKQWAERLLSL
LPSYRLENEDETSRIVLLKRKDSRIDNIIRGS
>A0A6P4TVY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Panthera pardus|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQDKNSKDKSVPKATRD
LMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQEYDPDD
HLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVFGLG
NSAYANHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTKFISRL
QALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDQQNLNSVVDVEDLGKIMNC
VKKEKREKEHQEEKSTLVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
MILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFLKLLHE
CKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLNSLKAL
AAKQQRTVYRLTLVKAWNVDELQAYAELVTLGNPDFIEVKGVTYCGESSASSLTMANVPW
HEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQELVQEYE
DSGGLANFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A662GP39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MSAATGKTYDELISPEYEKLRRAYIKQKYHFVGRYAVVKPCHWMKKSLVTRGEEYCYKQR
FYGIPCHRCLQMSPTIFCNERCIFCWRAHPEDVGAKIDELGPFKYDDPEDIVRNSLIEWR
RILSGYGGNPKVDRMMLEEAMRPTHAAISLVGEPTMYPYIGELIDAYFRYGFKTVFLVTN
GTRPDVLERLEREPSQLYVSVVAPDLETFEAVTRPIIPAKTAWEALMKTLDLLQSFSVPT
VMRITLVKGYNMKDVEKYAKLVERAQPTYVEPKAAMSVGYFKHRLDVSNMPKFSEVKEFG
LRLAELTGYKLIDEVVNSRIVLLSKLDKPIKLV
>A0A665U0Y1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
MALKKKSISKDINPWVYKAVKIQNCPDRAAVVHVSGVKIFYGSQTGTAKGFAKELSEEVT
NLGIPSEVIDMKDYDPDDQLPDECTSKSVCVFLVATYTDGQPTENAEWFYRWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGMRVMTRGEGDCNVVKSHN
GSIQADFQAWKVKFLNRLQALAKNEKSCSGNCKTGSSCKNKRNDGQLEVEKENASPQNAV
AEVMAEKLHLDYLSVLGDVHTVKLSKFTAVKKLADEEERREMITPALKEALTKQGYKLIG
SHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGT
EWHWKMDPAEKILQDSLEKHQNMIRQFRGVPGVRPERYEEGLAVKHCALSLVGEPIMYPE
INTFIRLLHSHQISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFW
PRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAMGQPDFIEVKGVTYCGESSA
SNLTMANVPWHQEVVAFVQQLAGMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYQ
RFQELAHVHEESGGLQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKTKDISGC
>A0A674NUE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Takifugu rubripes|TrEMBL
MKDYDPDDELAVECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGL
RYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRAEGDCNVVKSRNGSVQADFLAW
KVKLLKRLQALARGEKKICSGNCKTEGKCKNKRKVKGEENAALQNNSSEGELIESSSDEE
ESGLQEEKQSGTMLDMEDLGNIMNLVNKTKASTRITQRCFSFLKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQNMIRQFR
GVPGVKLERYEEGLEVKHCALSLVGEPIMYPEINTFVRLLHTHNISSFLVTNAQFPQEIR
SLVPVTQLYVSVDASTKDSLKKIDRPLFKDYWPRFLDSLRALGEKRQRTVYRLTLVKAWN
VEEMLAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQY
EIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVGVYEKTGGQRSFSALDYMAKTP
NWAVFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A397YVB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica campestris|TrEMBL
MAFSSSIHSRLALIALLSATTFYCIHKYRRLKRLKTLSSKLNPSAATTRGKIFFISQTGT
SKALAQRLRDLLASNGVAFDLVDPRSYEPEDLPKETVAIFVASTWEGGKPPKDGEFLVDW
LSESAEDFRVGSLILSDCRFAVFGVGSRAYGEAYNAVGKELARRMVGLGGVEMVPVGEGD
VDDGEMDGVFRDWCDGVIRVLKGGSAREGAEILQNGDVGLVSDGEYVDSTDDEEEEEGNG
DIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWT
KSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKE
IVKGALDLHTKMIKQMKGSLKAIDRPLFADFWERFIDSLKALQEKQQRTVYRLTLVKGWN
TEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVKAFSEALSLKSNGE
YEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFTSRDYMAETPSWAV
YGAEEGGFDPEQLRYKKERHHHPKPQPQAVLA
>A0A1S6HDH8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MISQKDRELLEKQHYAVIGNHSASKMCSWTKKSIKNEGVCYKEKFYGIKSHRCCQMTPCL
ACTNSCLFCWRXXXXXXXXXXXDEWKADDPEFIIEECIKSQKKLXXXXXXLKETNKTKFR
EAQEPMNFAISLTGEPTLYPKLSGLIRSLHKKGKTTFLVTNGLFPEVIKNLEMPTQLYIS
LDAPNEEIYTKIDNSLIDDAWSRLNKTLSLLKNLKTRTAIRLTLVKKLNMCNPKDYGILI
DRASPMFVEVKGFMNLGCSRSRLKWEQMPTFQEVKEFAKSLEKYSSYKIRDEQEASRVVL
MMRKGFMERKLTVQSIK
>A0A5E4LES7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MVGLYKIRPALVLKRFSPGFLFMAPESKQGNNFGSKGRNRIAAKNSAKTSPCEETEFLSQ
MQVSKLRSAKYELAGSHSGVQVCSWSKKALRREGVCYKQKFYGVECEQCCQMSPAVLWCN
ENCIFCWRPMEWMQKRGLSGASIDSPEKIISGSIAARKKLLYGFKGLEVVGPERFEKIAF
PSHWAISLSGEPTLYPKICELIAELKKLPGTKSVFLVTNAQETGVFRKMAKNSGFLPSQL
YVSLDAPNESMFKKVNRPSAGASWENLLRSLEIISGMKTRKVVRITLIKNVNDDNGLIGQ
WVDVIGRMAPEFVEVKSYMHLGESRKRLGRENMPSFSEVMSWTKGFAKASGYIVKDSSRP
SRIVLLVRQDLGGRSTKFKFAREEMAIDGEGIDF
>A0A452IT13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gopherus agassizii|TrEMBL
MDASVNTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWICFQFLATKAKKQDEKSTEKLTLS
KVTQDVLINGYTKPKMKEVYVTGVKVFYGSQTGTAKGFATILAEAILSLNLPAEIINMRD
YDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCKWLEEAVNDFRFGKTYLKGMRYA
VFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEGDCSVAKSKHGSIEADFDAWKAR
FLARLQALRKGKKKPCSGNCKKGKCKSKGRQSKEGSDREQRVSEQENTEVEDLFETTSEE
EAGAEEDGSSNSVIDVEDLGKIMGHMKKAKKECELEEEAGKTGPSQQSSGKNEDSERREM
ITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHKSLIKQFKGVPGVRVDRFEEGM
VVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTNAQFPVEIRNLEPVTQLYVSVDA
STKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKGVTYCGESAASNLTMANVPWHEEVVHFVRELADLIPDYDIACEHEHSNCLLI
AHKKFKIDGEWCTWIDYDRFQELIQEYENSRGSKTFTAADYVAKTPHWAVFGSRERGFDP
LDTRFQRKNKTKDISGC
>A0A0F4ZBL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thielaviopsis punctulata|TrEMBL
MDFSINGLARSNPLTMRDLPASGSVFEKQELLELWHEYRSVVIVAAAVVLIAVRVYLHST
DSGHENLVAIPKALDAEKKPLDTEKKAPDTKTLETDINALKTEVSALLASAKSKNRSETE
TTAVTPNTARPKAKNGPKRIVGGIKNSSSASPKEKNPETAASERKIQPLVFFSSVTTNTE
RIVGEFTPRLNEAIHSLDATPDITLLDAEVLDLAQIDFDDYFISPPASKAGVELVYLFLL
PSYNIDTINDAFLQHLQETHYDFRIDTAALVGLAGYSVFGFGDREGWPDENEGFCFQAKE
LDKWMAKLTGGKRAYPVGMGDTKVDYQQRLDEWLEGIKDVFGLIVETGGLGEGLPGSGNA
EESDIEEVSGDEDEGDDEVYVEAKPKKSKGGDLGDVEDLGKLVTGSETGSNSSSNSGSGS
GSSGPAPLAIDFTTYGKPKKTPVQNAAKEMVPVNSPTYKSLTKQGYSIVGSHSGVKICRW
TKSALRGRGSCYKFSFYGINSHQCMESTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKVLKGMAGVRAERYAEALRIRHCALSLVGEPIFYPHINEFLGMLHN
ERISSFLVCNAQHPDQLAALKAVTQLYVSIDAADRESLRRIDRPLHRDFWERFQRCLDIL
REKRNKHRTVFRLTLVKGFNIDDEVDGYADLVERALPCFVEIKGVTYCGTATSANAGLRM
QNVPFYWEVCDFVRALDAKLKERGLDYGIAAEHAHSCCILMGSGRFRVNGKWHTQINYQR
FFKLVEERGADGDWTPEEYMGDETPEWATWGNGGFDPRDQRVDRKGRPIEGKIEVKREE
>A0A8C2ANT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
VFLCLYKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNS
VYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQA
LAKGEKKACSGKCKSASCKNKKKHKEEAEDSQSHAEKNNSEEELMESSSDAESSAEEEKS
HGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENH
KNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTN
AQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYR
LTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQ
LANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSA
MDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A7C6EJH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSIPEDLKRLYRRQGYHLVGRHSAVKTCLWTRKSLRTSGGEYCYKQRFYGIPCHRCLQMT
PALGRCLQSCVFCWRAMPSDLSLDWDQLGFPQGEADDADSIVEGCIEAHREAVSGFGGNI
LIDRKIFAEANTPLHAAISLEGEPTLYPFIGELVDSFFSHGFKSVFIVTNGLRPDVLSNL
SREPSQLYVSVCAPDEEVYRKTCRPLIKDGWSRLMETLELLGSFNCPTVLRHTLIPKLNM
EDPSGYAKLALKSNATYLEPKAAKSVGFARRRFPYSEMAWHRDIREFSEALSKESGYKIL
DEHPPSSVVLLSKLDKPKKLY
>A0A8H3F1W9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Imshaugia aleurites|TrEMBL
MEVLGRPAAGSKDRGILIHELVLHQWHEYRYLVLLAAVLLGLVVILYFDWRLRKERSTSS
STASTPECRTSVEAGWLDEKPKSTAPAESEDERSERREPYENGAVQLPKVFVRPRSGPKR
VTGSIVDKRPKSESSVTGKIQPLVFFSSLTGTTERCAQSLLGELQESFKDYSSTIIEPQI
HDLSYIDYDDFYVTPPKSHKTDEPVQYFYLLLLPSYNIDTALDNFLAHLQETHHDFRIDT
APLSGLAGYSVFGFGDGEEWSTEAEGFCSQAVEVDKWMAKLTGRKRAYPMGLGDVKSDSQ
RRLGEWRDGVVKVLLDIAAHGGLGEGVAGSGDAVESEEEDADEVVKLGTTPKTGAGRLAK
RGRPQKTSRVDDLEDLGGKASLQSGDDISSQSRSPLPIDFTTSSLASTTPHIPKAMVPAS
SPTHASLTKQGYTIIGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMETTPSLSCS
NKCVFCWRHGTNPTGTTWRWQVDPPEMIFEGAKEGHYKKIKMMRGVPGVRAERFQEAMKI
RHCALSLVGEPIFYPHINEFVAMLHKERISSFLVCNAQHPDQLAALKPVTQLYVSIDASN
AESLRKIDRPLHRDYWQRFLRCLDILREKRFRMRTVFRLTLVKGFNIDEEVEGYADLVAR
GLPCFVEIKGVTYCGTSSSAGAGLTMQNVPFYDEITSFVEALNAALERRGLEYGIAAEHA
HSCCVLIASKRFYVEEKWHTLIDYEKFFERLESGIDFSPEDYMGPPTPTWATWGQGGFDP
ADERVDRKGKPKIEKVR
>A0A1V8UHC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rachicladosporium sp. CCFEE 5018|TrEMBL
MFNQGLLLPEELLRFWHVHRVEALIVAGLVLLAVRLALHWRSKRVNAAKIADGTTTAELA
PTPVITSRHVEDVKHALPSNAPARPKPGPKRVTGLRKAKPRNVQERTSLVRPIVFYYSLG
GSTRSYATQLAALLSQPKGAVETAPVEVLDLTEIDYDDYFISPPEHTATGRSISYFYLLL
IPSYDIDTELSNFLTHLEETHHDFRIDTAPLSGLAGYSIFGLGDQQEWPTERDGFCSQAI
EVDKWMAKLTGRKRAFPVGLADMRGSPEVKLEDWAAGVASMANDLATGTGFGEGVSGSGN
AVESGDEDEDAVLDDTEAKDDREGDVEDIGGRSPIPVDFTTTPRTKPTSPSAPKAMVPVS
SPTYTSLTKQGYSIVGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCS
NKCVFCWRHGTNPVGTTWRWQVDEPELIFDGIKENHYKKIKMMKGVPGVRAERFSEAMQI
RHCALSLVGEPIFYPHINKLLAMLHAEHISSFLVCNAQHPDELAALGPATQLYVSIDASN
KESLRKIDRPLHRDFWERFQRCLDILHTKRNTHRTVFRLTLVKGFNVNKEAEGYAALVDR
ARPSFVEVKGVTYCGTSTAAGAGLTMQNVPFYEEVCAFVLALEAALKRRGLDYGIGAEHA
HSCCILLADRERYYLPSGPSGERRWHTLIDYAKFFQLLESGDAFGPEDYIGDATPEWASW
GKGGFDPRDERVDRKGKPKDILEELPSAVMIREAEVTG
>A0A147JZN9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon YNP_N21|TrEMBL
MAISPPQLSRLEMAGYRFVGEHRHSAVKVCHWTRKSLLNLGVCFKEKFYGRELGLRSHRC
LQITPSIPFCDHRCLFCWRNTEITASSWIGGVDEPRDILDGSILAQRRLLSGFGGNPKVD
AKKFEEAQEPRHCAISLAGEPTLYPKINELVEECGRRGMTSFLVTNGMHPEALEKLVEPT
QLYISVVAPDPETYKKVCRPMAPKGWERLNLSLELMPSFRCRKVIRLTLVKDINLKDAAG
YAKLIEKAKPDFIEPKAYFAVGYSRSRLGVSFMPSHMEIRKFAEELQELTGYLIADESEP
SRVVLLRRSA
>A0A3P8TGG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Amphiprion percula|TrEMBL
MLSLFVTVLVFTGGVCSSDSRASQDVHSPSENYLMSIWHNRLYVYSAAALLFGVWFSLKM
ALKNKSFSKDAALWVRKAEQKNNSSSDRDAEVHVSGVKIFYGSQTGTAKGFANELSEEVN
TLGIPAEVIDMKDYDPDDQLADECVSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDF
RYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRN
GSVQADFQAWKVKFVNRLQALARGEKKSCNGNCKTGGSCKNKKKEKQEEEERAAAQNNSS
EEELIESSSDEEESGPSDEKKSGSVIDMEDLGNIMNSVKKAKGKGEVQGDGQMVKLSKLN
GVKRVEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVEKHQSMIRQFR
GVPGVKPERYEEGLSVKHCALSLVGEPIMYPEINAFIRLLHFYRISSFLVTNAQFPQEIR
SLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWN
VEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQY
EIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELAKAHEESGGQQSFSALDYVAKTP
SWALFGAQEQGFDPADTRFQRRNKTKDISGC
>A0A0B4IG93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metarhizium majus (strain ARSEF 297)|TrEMBL
MSAVCEKTDPLQGVFGGLPGAKFDGPKDIVELWHGHRTPIIICALVVLVAIRIYIHKIEE
AEPLRALPKQFEKQRIEPSSANKLPSAVNSEKPIAKPNGPRRIKGGITKKPATEETKEYD
KSRPIKTMVFFSSVTTKTEKIAQQYLSTLEKSVGQLSRGSERQFLKPELHDLAEIDFEDF
FVSPAKTVEDAYLFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLATLLGYSVFGF
GDKEGWPDEADGYCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHAERFDEWSSGVKEVI
AHVAISGTLGEGVPGSGDAMESDAEDVAEDDDGEVLIGEDISGDDRESSRPLDDVEDLGR
MLRTSDGNGTANGKKAPLAVDFTSYGASSAKKRTPTAPVIKEMVAKNSPTYAALTKQGYS
IVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNP
VGTTWRWVVDPPEMIFEGVKENHYKKIKMMRGVPGVRAERYAEALKIRHCALSLVGEPIF
YPHINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHR
DFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTY
CGTSTSSNAGLSMSNVPFYWEVCEFVKALEERLKAKGLKYGIAAEHAHSCCILLASERFL
VNGKWHTHIDYKRFFELLEERGADGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGR
KIENVVVREAPPPDSW
>A0A1J4UA66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG1_02_47_40|TrEMBL
MGQKPACPKTIPPEVFSELCSQGYHIVGTHSANKRCMWLRECLRGGEFCYKHKFYGISSH
RCVQCTPVLLFCNHACKFCWRIMPEAKEKFEEMPTASFKWDSPQEIAEGLLKAQKDIVSG
YGGNEKTTAKLCEESRSPKHIALSLTGEPTLYPYLGELIGEFHKRGLTTFLVTNGTTPQA
LQALSSLPTQLYISMAAPNKEIYLQTCRPQTPSLWENYCKSLQLMGGKRIREGTRTVLRM
TLVRSLNMGGIDGYAKQIAIARPMFVEVKSYMHVGKGREKRGLALGDMLSMQEIWEYAQN
LAKLTGYLYTDEHPISRVALLCRDKKAQKGRFLKV
>A0A8C6LNE6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
LQNPAAIFNMISSQCVGRSVCVFLVATYTDGRPTENAEWFCKWLEEASTDFRYGKSYLKG
LRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRILTRGEGDCNVVKSRHGNVQADFQA
WKVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNEEVTSQDASAEVTCPFSACFREGGRG
TSYICSDLCNSQMVKMNGGKKTEDDGERREMITPALREALTKQGYKLIGSHSGVKLCRWT
KSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEN
ILQESIEKHQNMIRQFRGVPGVKAERYEEGLEVKHCALSLVGEPIMYPEINTFIRLLHRH
RISSFLVTNAQFPEEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALG
EKRQRTVYRLTLVKAWNVEEMMAYAELITLGQPDFIEVKGVTYCGESAASSLTMANVPWH
QEVVAFVQQLADMLPRYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVVVHEE
SGGQRTFSASDYMSRTPSWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A384AGX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Balaenoptera acutorostrata scammoni|TrEMBL
MGPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKAPRDL
MTNGYISLQRKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGWPTESAEWFYRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKRCGGNCKKGKCESNQHGSEAVEPGPHAQEGSHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSAAKNEASERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQAEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYARLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIADYEIACEHEHSNCLLIAHKKT
>A0A5N5DL88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lasiodiplodia theobromae|TrEMBL
MASNDSPQPILTDLLSLWHSSRVPVLLTVCAVIALTRLFQHLRQPRQKLSASPIPGSPTS
KVDQIAAPWAKIEEIPPVDEKAAELVDVEEITIAERPLVRPKPGPKKVTGSKVPRQAKRT
CSFDAARDQVQPLVFFSSLGGTTEAAAKKVAEELNQWIYALDSDSIPRPLNPQVLDLAEI
DYDDYFISAPKGEKNVKYVYLVLLPTYNIDTMLDNFLEHLQETHHDFRIDTAPLSGILGY
SVFGFGDQEGWPTEDEGFCSQGKDVDKWMAKLTGKKRAYPLGIGDVKSDAQERLKEWRLG
VQDILLDICAGKGLGDGVPGSGDAMESDEEDIDDDEVDSETTQPLKPRKTKAKSSLDDVE
DLGKMVKSEVDPDEPMEVDFTTYKSPVKNAAPAAPKEMVPKTSPTYSSLTKQGYTIVGSH
SGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTW
RWVVDPPEKIFEGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHIN
EFTGMLHKEHISSFLVCNAQHPAQLATLKQVTQLYVSIDASNKESLRKVDRPLNRDFWER
FCACLDILREKRFQQRTVFRLTLVKGFNMADEIAGYADLVERGLPCFVEIKGVTYCGTAT
SAAAGLTMQNVPFYAEVQEFVEALNKELNDRGLEYGIAAEHAHSCCVLLASTRFRRQVNG
EWKWCTLIDYDRFFQLLESGEDFKPEDYMGEPTPEWALWGNGGFNPEDERVYRKGKNKDK
VVEETSKAILEI
>Q8I3L6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum (isolate 3D7)|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDTSNTNDTNN
TNNTNIMNNTNNTNIMNNTNNTNIMNYTNNIRTGENCVSESETSSNQSYPDDEDEQIEVE
DLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSY
QCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYG
IIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPQELENLNT
VTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMEN
EIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINKKKALSH
IYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVETPHWAI
YGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A7J4I7L3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MDAAYKKLLEKQGYKFIGEHSACKTCHYTSASIARKGVCYKQKFYGIQSHRCVQMTVAAN
FCNMDCVFCWRKRNNSPFGKIDDPVALVDRAVETQRKSLSGFGGSANADRQKFIESKKPL
HFAISLNGENTAYPRLGEFIAELNKRGYTSFLVTNGQLPEVLAKITPPTQLYISLSAPNE
KLFKSVDKPMHKDGWQRLLKSLDILQQMRKEGKTRTVIRLTLIKGLTMQPGHAEQFAILI
KRADPMFVECKGYMWIGTSRERLERENMATHEEIKKFAAKTGKHCGYRVIDEQEESRVVL
LSQEDGPERFLKLETEAISF
>A0A1D3S1U8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium chabaudi adami|TrEMBL
MVTKREDELVLPPNEGGNINTYSIQKKTKINLTLIYGSEGITSYKAAKEFLNELIYFFNN
ILNHFNTISTITKGDNKNNTIFEGSISNEINNIEDYMLEYFRSKLLKTNKKNKDGKFVKK
CKNEKTNNESSKCDNEVKDIFDNLKKYEKNMIKCGNTHFNNYLNCSIENNISKIHFDFVN
GNEFDSYTFFENSENNDLNILFMLISTYNFGAFPTNCYKLEDILTDLVNDFRVEKNYLKN
IFYSCVGFGNKEYGSKYFCTPIKKCDKLLSSLGANKLEKTLKLCSTMDNEEEFIHWKSSL
LKKICLSLFLYNFNYTKFSNNFFHYSNRKNYNTLKYYCTYFCKKSESINDEERQASKSVD
NNNIHKCDCITNGVSSEHFDQSKESGDNQNKLTNKINGHISFSTSKMDANNTEKCGCTSS
NCLNGNDKYINEKEVINNNFETSIVNGCCKNEYEQDGELINSDFSNESMNENNDEINCNS
SEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKAQIRGRGGCYKHTFY
GINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKEL
KGVHNIINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNEL
KKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKERKERTVFRFTLVKEY
NMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSK
RSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNANFSAIDYCAET
PEWAVVGAPECGFNPSDQRVYTKGKNKNKNNINTMEVKT
>A0A8D0AFT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sander lucioperca|TrEMBL
MSRFGKLNLNLFLPPVSQNAHSPSESYLMSIWQNRLYLYSAAALVFGIWFSLKLVLKKVS
CHLLRISHLLLCMVIDLLYFSVFLSADLCKTVLSVAAGIRGSGFAEELSEEVKTLGIPAE
VIDIKDYDPDDQLADECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYL
KGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADF
VSWKVRFLKRLQALAKGEKKSCSGNCKTGGLCKSKRKDGQEEEEEKEEEKEEKSSSDEED
SGLQDEKNSGSVVDMEDLGKIMNSAKKAKERQTCEEREFKALYPHFCAVREFEKLSNKCC
SFSFCAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQSMIRQFRGVPGVKPERYEEGLAVKHCA
LSLVGEPIMYPEINTFIRLLHSHRISSFLVTNAQFPKEIRSLVPVTQLYVSVDASTKDSL
KKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIE
VKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLMAHTKFK
VDGEWWTWIDYERFQELVQAHEESGGQQGFSALDYMAKTPSWALFGASEQGFDPADTRFQ
RRNKTKDISGC
>A0A7D5R834|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus ureiphilus|TrEMBL
MSCSGEIVKEDDRLIQIKPAISEQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMEPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEETKSIFLVTNGQE
PDMIQKLQDKDALPTQLYLSTNAADYESFMRINKPKYDDSWERWNRTLDMLKDLNTRTVL
RVTLIRNYNDQKEVIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHANMLEMEEVKKFS
EEIAKQSKIFSVMDESIVSRISILQNNERCIDRFIPTYANTN
>A0A3P9DF16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Maylandia zebra|TrEMBL
SKDASKEKNDKVDKAAKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKSLGLPA
EVIDMKDYDPDDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTY
LKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSIQAD
FLTWKVKFLNRLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKDDLVESSSDEDESG
LPDEKKTVLDVEDLGNIMNSVKKSKEESQRDGQMVKLSKLNGVQKIEDEGERREMITPAL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVKHC
ALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRYNLVPVTQLYVSVDASTQD
SLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPDF
IEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHTK
FKMDGEWWTWIDYERFQELIQAYDESGGQQTFSALDYVAKTPSWALFGAQEQGFDPAETR
FQRRNKSKDISGC
>A0A0V1AWI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella spiralis|TrEMBL
MWKAYYSMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVFDLQHYNPEGHLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKICR
WTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPA
EKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMH
SLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDI
LREKKQRTVYRLTLVNRYNMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKDSKITMANVP
WHADVVDFVQQLVFQLDDYDIAAEHEHSNCVLIAKLNFKIHGQWYTWIDYEKFFSLAERF
KKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A0U1LV84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces islandicus|TrEMBL
MKNNRYSSIMESPAESGLLAAWHAFRIPIILILTALVLLVRFYSQPKAKTSSSSSLPPSP
RLEKVVGLGDKPSLVIPTIDAERNALKDKPTASGPKRIVGNRQPRGANKRQEADSSARAS
FIKPVIYFASLTTSTARRAHWLEEELRTAAQAVSKGADKEYGLLPPEIYDLAEIDFEDHF
VSAPKPPPNSPHTRYFYCFVIPTYNIDTIIDTFLSHLDETHNDFRIDTAPLSGLAGYSVF
GFGDTEGWPTEEEGFCSQAKDLDRWMAKLTGKRRAYPLGVGDTKADPDHALKEWTTGLTE
VLGEIVETGGLGEGVPGSGDPVESDEEDTDDEESEQTAKNSKKAQSMVVDLEDINVGGSA
NKKRGDPLPVDFTTKSDKSSNNQSTVKEMVPSTSPTYAALTKQGYTIVGSHSGVKICRWT
KSAMRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPDM
IFKGVKEGHYKKIKLMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFVGMLHDE
QISSFLVCNAQHPDQLATLDRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILR
EKRNIQRTVFRLTLVKGFNVEDEVKGYADLVEKGLPCFVEVKGVTYCGTSSSASVGLTMK
NVPFYEEVVAFVEALNEELKKRGLKYGIGAEHAHSCCILLASERFFVNEKWHTRIDYDRF
FELLQKEKSEGTSFCPEDYMRETEEWALWGNGGFDPNDTRVRKKGRNKDRPAVEQ
>A0A6P7PCV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Betta splendens|TrEMBL
MLCFLVIVLLFISRVATLDIKVSQGDHSASEKYLMSIWHNRVYVYTAAALFFGLWFALKT
IKRKNSKDASPSVYKAVKNNGRPERESVVHVSGAKIFFGSQTGTAKAFANELSAEVKALG
IPVEVIDMKDYDPDDQLADECTSKSICVFLVATYTDGQPTENAQWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSFYVGHYNTVGKNVDKWLWMLSAMRLMTRGEGDCNVVKSRNGSI
QADFLAWKVKFLKRLQCLVKGEKKKCSGKCKHGGSCKNKTKDRKAEEGEQAAHNNSSEED
LIESSSDEESGLTNERQTGSVVDMEDLGSIMNSVKKAKSKEDGVRTEDEAEEREMITSSL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDPAGKILQDALEKHQNMIRQFRGVPGVKPERYEEGLAVKHC
ALSLVGEPIMYPEINTFIRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDS
LKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFI
EVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHSKF
KVDGRWWTWIDYERFQELIQAHEESGGQQSFSALDYMAQTPSWALFGATEQGFDPTDTRF
QRRNKTKDLSGC
>A0A7M1UP21|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermosphaera aggregans|TrEMBL
MSINFHEVKKKREEFWNSSLVYKAIHDRLVKQGYHLIGTIGAVKRCHWTKEAVVRKRFCY
KCLWYGIESHRCIQMTPVAAWCWNRCLHCWRIQPEDVGMHWDDTRPPVIDDPEVLVEESI
RVHREIMAGYKGNPSADQLMVEEALKPKHAAISLTGEPLLYPRLSELIEEYHKRGLTTFL
VTHGTRPDVLKSLVKEPSQLYISIESWDKESYEYFNRPLVPRAWELFQETLELIPSFKSP
TVFRFTIVKGYNDNEKALESFSRFVEKAQPTYIEVKAYMFLGGSRGRLEHSNMPSHDDIR
NVGRILSEKTGYKLLSESIPSRIVLLSRIDKPIRHGKGCPDGVEHPEKYAPAFSKEYEEL
TD
>A0A2H9M171|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon CG06_land_8_20_14_3_00_37_11|TrEMBL
MNREVYTKKRYNLVGKHSAVKLCNWTRRSLTGKGECYKEKFYNIKSHRCLQMTPAVAWCE
HSCLFCWRPTEFTSGTSMENVELDEPEIIVEKAVEAQRKLLSGFKGNPKTPKKIFEEAVN
PNQAAISLAGEPTLYPKINGLIREFHKRGFTTFLVTNGMNPEVLDKLKPLPTQLYLTIPA
GNEEDYLKITRSAFGKKGWDNLMKSLKIMKKLETRRVIRLTLVKGLNLKNPEEYAELVRK
ANPDFVEAKAYMHVGSSRQRLEEFHMPSLSEIRQFSQRLAQILGWKIIDEHETSRVCLIA
KEDYNWRFL
>A0A0V1PBD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella sp. T8|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKI
CRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTD
PAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHINELISK
MHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSI
DILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSKDSKITMAN
VPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAE
RFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>W9DWS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolobus tindarius DSM 2278|TrEMBL
MPRKRKNKNKDSIDDESGITDFKSLLRKQGYSLAGKHSAVKTCMWLRRSMKDEGECYKSV
FYGITSHRCLQMTPTLMCNQKCLHCWRPTEVDVPMPVGWDSPVEIVGSSIESQRKLISGF
GGSAPLERWKEGNDPKHVAISLSGEPTLFPHLDKLIDEFKAQDFTTFVVSNGTVPEMMAK
INPAQLYMSLDAPDRETYEKVCLPKSPVLWDNILKSLEILKSKETRTVIRITLIKGVNMF
DSEGYAKLIKIAEPDYIEVKAYMHLGFSRKRLPREAMPQHDEVIDFSEKLAQHLGYKVAD
DVEVSRVVLLSKDGSVTHLL
>A0A5D3AES5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium mustelinum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPQTYEPEDLPKESLIIIMASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A2I2EZS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus candidus|TrEMBL
MAQGSLVEGLLTLWHAYRVPILVILFTALLVSRTIGITGSKSKAASAFSNPTSPRSHSPE
KSEKAQLDDARDRPAPAPTPADAPKAAAAGPKRVSGKKPAKVAGRRAGAEPAPQLSAIQP
IVFFASLTGTTEQYAKVLMEELTTAAKDQADAENPERGILPPQLQDISYLDFDDFFTTAP
KPPPNSPGTRYLYCLLIPTYNIDTVLTTFLGHLDETHNDFRIDTGSLSTLAGYTVFGFGD
KEGWPTEDEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDGEAALKEWSRGLQDIMRD
ILDYGGLGEGVPGSGDALESDEEDVDDEESGKSNKNGRKRGKPQAVVDLEDIKMGAGDSG
SAAPIPVDFTTGGQSAPSTQSTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFD
GVKDGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINGFLDLLHAEHIS
SFLVCNAQHPDQLETLHRVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILREKR
HVQRTVFRLTLVKGFNVDDEVKGYADLVEKALPCFVEVKGVTYCGTSSSAGAGLTMKNVP
FYEEIAEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASERFHVDGKWHSRIDYQRFFEL
LEKENADGTSFRPEDYMRETEEWAMWGNGGFDPNDERFYRKGKKKALEAAATEAATDAAT
EF
>A0A7J4RVP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGIASHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVAREKWLDAQNP
KHVAISLNGEPTLYRRLGEYIDLCHKHGMTTMLVTNGTFPKVLERLDPLPTQLYVSVDAP
NKEIFNKVCKPKWNSRAWEQFEKTIDLLPSLDTRIVARHTLMKGINMSDRNIREFAALDN
RADPDFIENKGYVFVGNSRENLSAENMPSHDDIMEFSAKIAPLTGRKILSDSKPSRVALV
GQQITPIPIPKPTMFFPEDLGIAPPVKHLPIIQ
>A0A1E5RDN2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hanseniaspora osmophila|TrEMBL
MSNLEESDKSIIAKTPGSVVFTAIIVIYLVEGGRFTFALAFSTIYTLIRLEISKTESQKP
KKKVCCGGKGGGCCSTKNAATGKSTQXGKKSCCGGACKSKSKADTVLNANVSSSLETESQ
XLGNQFDEYAIDFTNAFKNPSKKXKTTKKKQPKKIVSSKPPVTKALTISKEDLLNSQIYI
FYSTLQGVSERAATTVSERLEFLHPNDLKKKPIRVHIDELDDLEDYFVSVPENAIYIMVV
PSYDSDSPLDVAIDGLEEISNDFRIDKYPLTKLVGFCVFGLGDSESWPEKFCYQAKQLDV
LLAKLGGRRIYPLGEYCTKTNAWGKIEEWSDLLGETLKDDQPILYQYDEAEDDNEEQEPV
IDLEDIGKSEELDTTMNKKMVAKNSPTYKNLTKQGYVVVGSHSGVKICRWTKNDLRGRGS
CYKQSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWEVDEPEYVLEEGLKGH
YSKIKQLRGVPGVIAERFQKAFQVRHCALSLVGEPIMYPHINRFVDLLHEKDISSFLVCN
AQHPQQLRDMYKVTQLYVSIDAPTKTELKKVDRPLYKDFWERMLECLEILKTVQSHQRTV
FRMTLVKGFNMDQVTAYADLVAKGLPCFIEVKGATFCGSSDGNGNPLTMQNIPFYEECVK
FVKALAAELNSRGLAYDVAAEHAHSNCILIASKKFYINDEWYTHIDFDKFFELLNSGKSF
TNMDYIAKTPEWALFGNGGFAPGNTRFYRKNRKEVTPM
>A0A7J4EGI8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MQKELKKILKKQHYAIVGTHSGVKLCHWMRQSLFYGRECYKQTFYGVESHRCLQMTPAIN
QCTQNCLFCWRYQGSTELTIKNVDDPMFILEESIAAQRRLITGFKGDPRCDQRKWREANN
PKHVACSLTGEPTLYPKLGEFFEACHKRGMTTFLVTNGTNPEALENLDPLPMQLYVSVVA
PNKDVYKKLCRPAVPDGWERLQETLELLPSLDTRTVIRHTLVAGLNDDERCIRDYMRLDE
KASPMFIEPKAFVFVGYSRNRLTIANMPSHTKVKSFGEKLAEEMGFFMVNEKPDSRVVLL
SKNKKVERLSKQS
>A0A498GSS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. MSH10X1|TrEMBL
MPLEERKEKAGEDFPEVQEESRDRESATLPFDIPDFQTLLKKQGYALAGRHSAVKTCLWL
RHAMNGQGFCYKSKFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVAVPAPEEWDSPEKIV
EESIACQRKLITGFGGSPNALKERWLEGNEPNNVAISLSGEPTFYPYLPQLIEEYEKRGF
TTFLVTNGTIPDMLAKISPSQLYMSLDAPDLETYLKVCQPRSPALWKKINESLSILNQKK
SRTVIRTTLVKGENMSKPEAYARLIEKASPDFVEIKAYMHLGFSRLRLDRSSMPTHEEVL
EFSKELANHLGYKIADESEISRVVLLSKDGKKSPAKKFSCPD
>A0A662M7C8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDEQLKRIFEKQGYTIVGNHSAVKHCHWVRKSLLFNIPCYKQTFYGIESHRCLQMTPAAN
QCTQKCLFCWRYQGFTEMRIDEKDADSPEFIFEKSLEAHRQQVSGFKGDERCDEKRWEEA
REPKHVACSLTGEPTLYPFLSEFFEICHRHGMTTFLVTNGTMPEVIENMDTLPTQLYVSV
CAPNEEIYKKLCCPMIKNGWERVNKTLEILPSLDTRTVIRHTLVDGWNLGYEKEYARIDR
KAEPWFIEPKGYVHVGYSRERLTIENMPSHDKIRAFGEKLAHETGYEFISEREDSRVVLL
GRGKERKI
>A0A662LAB9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDKEILKILRKQRYAIVGRHSGVKPCHWLRESLLRNRTCYKQKFYGIESHRCLQMTTAIN
HCTQNCLFCWRYQGFTETSIAEPDDPVFILDESIKAQRVFLTGYKGDPRVDRKKWEEANE
PKHIACSLTGEPTLYPRLGEFFEEAHNRGMTTFLVTNGTNPDALMNLDTPPTQLYVSVTS
PNEEVYKKLNRPIIKDGWERLQKTLEILPSIGTRTVIRHTLVKGWNMDEKFIPEYAKLIE
KAEPLFVEPKAYMFVGYSRKRLSIANMPSFDEVREFARKLSEETGYYYLDESRDSRVVLL
GREKGDTRIR
>A0A2H9R272|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon CG_4_9_14_3_um_filter_37_18|TrEMBL
MDENLKKLLEKQQYRFSGNHSVVKICRWTKKSLVEGKVCYKEKWYPPVKSHRCMQMSPSL
VCNHRCLFCWRLHSGDRGFSWKESFEGLVLDEPKDILEKCIEQRKSLLTGFKGFERVDKR
KWEEALKPNMMAISLTGEPTMYPKLDELIQEAKRMNIISFLVTNGTLPDRLQSLNTKPFQ
LYVTLPAPNKETYKKLCQPSTPKLWDKIMETLELIDSFDCRKVIRLTLVKGLNMVEPEEY
AKLIEKANPDFVEAKGYVHVGESQKRLPMDAMPYHEDIIEFSKEIEKHSSFRIKDVFKPS
RVVLLKK
>A0A662MAV3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MVIPQLESILKRQGYYLIGNHSAVKVCYWTKEMLVNRRPCYKGTFYGIRSHRCIQMTPAV
DHCTFACLHCWRFQGFTNVGFEEDPDDPEYIVEESIKGQRILLSGYKGDPRVPKELFEEA
YNPIHVAISLTGEPTLYPRLPELVRAYHRRGFTTFVVTNGSVPETIEKLMDEEEPTQLYI
SITAPNKDLHKKINMPRIKDSWERVNRSLELMSMMNARRTIRITAIKGLNMDKKYVPEYA
RLLEKADPDFVEVKAYMYMGYSRYRLKPENSPKHFEVKDFAVKLAEELGYVVASERDDSR
VVLLTKPDSERRVDIMLKLGH
>A0A662LK93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MINKKIRDVLEKQQYRIVGNHSAVKICHWTKESLTRNRVCYKEKWYGIKSHRCMEFTPST
IWCDHHCLWCWRLQNGDRKELKWKEYPFNSKIDDPAEILDKAIEARKKLLTGFGGNNKVD
KKKFKEALEPTSIAISLSGEPTLYPRISELIEECHKRNIFTFLVTNGTTPEVLEKMTKPS
QLYITLPAPNEKVYLKSCRPIIKNGWKKIMKSLELLKTFDCRTVIRLTLVKNLNMINPEQ
YAELIERANPMFVEAKGYVHVGESQKRLKQENMPTHEEIKDFAKEISKYCSYKIKDDFRP
SRVVLLMQ
>A0A842KK51|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MHVKEILEKQGYAVVGRHSAVKLCYWLKKALVENIPCYKSTFYGIKSHRCLQMTPAAYHC
TQKCLYCWRFQGFTLKEIKREEADDPKFILEKSIEEQRRLLSGYKGNKKVRIEDWKEAIE
PKHVACSLTGEPTLYPFLSEFFEECHKRGMTTFLVTNGTNPEFIEKMDTLPKQIYVTIAA
PNEDLYKKLCCPLVKDGWKKINETIELLPSLNTRTVIRHTLVKDWNLGYEEEYARIDEKS
DAWFIEPKGYMHVGYSKERMHRNNMPNHEEIRNFAEKLSDLTGYKIEDERVDSRVVLLGR
GKKREI
>F4BW35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6)|TrEMBL
MQDTMAEKALARQGYHLVGSGAVKPCLWLNRSMRGGDQCYKNHFYGIASHRCVQMTPTLE
CNHLCLHCWRPIDDPIPGKEPMEPAELLEGILRGQQRFISGYGGSSTTDPVRLEEAREPK
HMAISLMGEPTLYPYLKEFIDLVSRRGMTSFLVSNATRPEVLAELRPTQLYLSLNAPDEE
RYRQICNPSKDLWPRILESLELLKEHRCRSVIRMTLVRGQNMEGLDDYARLIGDAEPDFV
ELKAYMHLGRSRTRLERTAMPQHSEILALADSLAGLLGYHPEADVPLSRVALLSRGRISR
FIEMRDHK
>A0A1D3RHR9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium malariae|TrEMBL
MIMLGGKSDHSALLKTIFEIYSNEKKAKINVKIIYGSESLNSYKRAKEFLNELIEFFKNI
ITFCKEIKRITCENENITRNETNELEVELLEYFRSYLRERKKVLLRKNEGKGLLIKRKET
TDEGSERNVRNVVNVVNVVNNEQNRMHNDKQLSELNNDLLDAFGRNVKTSSDTVFSNYVD
CYIKTSISTVHIDFIDGNEFDHYSFFDNLEYYDLNILLLFVSTSNYGSFPKNCYKLEEHL
KDLLKDNKIENNLMKNIFYSSIGFGNKQYGTNYFCAPISTCDRLLSTLGANKLYRTLKLC
NQEDNEEIISEWKCNLFKMLSLSIFFYCFNYATVGRLAQLSIDKTYMALKYYFSFFCSSK
QKPALEGVQDDKLKRKKKKKKKGKRMEVNMEEREANELEVGVDRGEHMLTQTLAQTQRNK
LHNKTEQCSCSFDSGNESRSGKSKSIICCDEKRMNSEGSLGNEVHNGNASLCNSGSSIGI
GCSSDANNSGHAANKRKGIRQQDECDSNNCEQSTRIISSESRSNGEGEEYSYSSSTDVGT
SNKTAMTNCSSGDEMEDLVSGEPKDMLSINQRNKLTKEGYKIIGSHSAVKLCRWTKSHIR
GRGGCYKHTFYGIISYQCMEATPSLACANKCVFCWRHHKNPVGTKWKWNKDNAESIVEQS
VKKHQGMIKELKGVQSVISERFTNGMNIRHCALSLVGEPIMYPDINKLIDELHKRKISTF
LVTNAQFPEELKKLHKVTQLYISIDAPNKEALRNIDRPLFKDYWERYITCIKILKTRKER
SVFRFTLVKEYNMMGEEILGYSKLIELGSPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEV
YQFAFHLINSKQVLSDIYEITCEHKHSCSILIAKRVFKINNKWCTWINYEKFHLLVKEKK
DFTAIDYCLETPSWALIGAPERGFNPADQRVYTKGKNKVKNVNVNIPIENDASKGGAP
>A0A843ARB6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon|TrEMBL
MKDDLREILQKQQYRLCGDHAGVKLCHWMKQSLLKGRTCYKQDFYGIRSHRCLQMTPAVN
DCTHNCLFCWRVRGFESTVTKWQDPETVLDTCIEGQRQLVTGFKGDPRCSPAMWEEARQP
RQVAISLAGEPTIYPYLGDFIELCHRRGMTTFLVTNGTFPKVLEELSELPTQLYVTVAAP
SKDIYKKLCVPQIDDGWERLMETLELLPSLNTRTVIRHTLVKDWNLGWEKEYAALDRKAD
PTFVEPKGFVFVGDSRRRMSMDNMPSHSEVLEFGRRVADELGMCMLREKSDSRVAVFGES
GTDTKIPGLDQSE
>L8G923|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus destructans (strain ATCC MYA-4855 / 20631-21)|TrEMBL
MANNEYFGADIASHATENYFMALWHTYRIPLILTLLALLLITRAVLHLKFGREKIIYTPP
PTPSEKTHVAANPQREQLVEKAPIPAEVKKAGPKRVVGKVTRKKSLLRDQPASKDVRFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLSPIAHDLAELEDYDEYFLGLPK
PEDASQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEDAEEDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQTESEDQDEDEGAVDFTTYGKKNPKPSAAPKEMVPKGSPTYNALTKQGYIIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVIDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWQRF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTPSS
GAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFERLESGEPFTPEDYMGPETPEWATWGNGGFDPRDERVYRRGKNKVPLRVVG
EEGEEGEEGQKEEKPKLVEI
>A0A7R8X6N9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Darwinula stevensoni|TrEMBL
MKATRDNQLGMNLVKALLPRGPHLARRMSTNPSMTMEEMLKRIGSYLVPHSDKAMLDPTQ
IPGTQAELPERRMQDSFCEVVLPLGSNKDLHPRYLTKAGGVRIGRLLEDMDVFAAWVTLH
HLLNPKEDESQPLPYTIVTALVDEISFIKGKVSPDKDLRLSGHVSWVGKSSVEVSLALHQ
WGPEGQPWNLITHALFVMVLRDAIRDRGVPANPLKLGSESEILLYKRGEANALRRKNTRE
ESLLRKPPNEQERIIIHDLFLSTLDPLRHTFQSRVKPPGHMWMEDAKLKNVIICHAEFRN
RFGKIFGGFIMRQAFELAWANAYVVSRQAPTIEFIDDIWFRRPVEVGSLLYMASQVVFTE
GCHLQVRVSAEVMNPVDGQKEETNVFHFTFVVPKEVDRMLPKAYHESMLYLEGRRQFVAR
CEMWAFLGLPAVSGFTGALFGLLVLFVVWMFLNSDKSVGKSASESFVKAEPPTEEAEPPT
GLADAPMRKVDAPTEKVEAPPGQEPGKAKVKKAKKSCCSDGGTCCSKKDENLLKVLPSIQ
RVLLLYGSQTGTAQRFAEELYEYLGSLGLDVQIHGMKGFDPEDRLVDEVRILVSRCGSHA
SSIADGLLEGTAFLFLLSTHTDGGPPESAAWFHRWVLDAAEDFRVDHTLLQGMAYAAFGL
GNSAYGPDFNKARILRWEGFGCGFCFLASKELDAALVKLGAKYFIPLTLGDEDGAASANG
GLDKDFAEWKKRVQAALFGSDEAGKPRKKKDSGHQCGCGSKDGKGGGDGHQSGSCSSECS
SDEDEGKDEKGGGEKVMDMEDLGSYMSQLLSAKKGKRPTPEGRGESGVKEMITPDLREAL
TKQGYRLVGTHSGVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCW
RHHSNPVGTEWRWKTDDPEDILRDALQHHYGLIRQFKGVPGVKADRMEEGLAAKHCALSL
VGEPIMYPHIDAFLRLLHRRRISSFLVTNAQFPQPMRPRTEKDELTLLLSVKMESRELSP
VTQLYVSVDAATKERLKGIDRPLFGDFWERFLECLEVLKDKGQRTVYRLTLVKGWNDEEV
EAYAQLVDLGSPDFIEVKGVTYCGTSKNATGGLTMERVPWHEEVVRFVEALQRHLDEDYD
FACEHEHSNCVLLAHRKVELRGKFRVNGEWQTWIDYDKFQDLVEEYYESGGFKSFTSLDY
TARTPPWALYASTERGFDPQETRHRGKGKGKAQRPKDGGC
>A0A816MUR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria magnacalcarata|TrEMBL
MAVDIDILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSSKS
QPSTKSNSDEKNGITIVFGSLKGNSRTFAKLTSEKLSNELNRHVILQDLKDITDPEEFLQ
IQAKEQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAVFGCGNSL
YTENFNKVATEIDRCLSELGAKTLLATELADENTGKSIYGGLEGHYSKWSSKLVSALESK
ATGKCGCRANEDSVTCCKSPSTNSHSKETNGTNEVLIESDDDDEGGNKDGEEDVMDLEDM
GDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIDNHYKM
INTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQF
PDEIRVLQPVTQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKTKGQRTVYRLTL
VKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVVTFVRLLCE
RLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGAETFTSLDY
MAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>A0A842U0N0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MSNKSNVKKILEKQGYRFVGNHSSIKICRWTKKSLIDEGECYKSRFYGINTWRCCQISPW
IGCNNKCRHCWRPIEINFNKLINKNKIDSPEFIINNSIKSQQKLLTGFKGNKKINSGKFR
EAQEPMQFAISLTGEPTLYPKLGEFIAELRKKGKTSFVVTNGLQPGVLSNLNKEGNLPTQ
LYLSVNASNKKSYDKWHRSKEKNAWKKFNDTLELFPKLKGKTRTVIRMTLVKDINMKPEM
VEEYVKLIKKARPDFIEVKGFMSVGFARKRLGYEMMPRHNLVRDYAEKIAIALNKKNEKY
KILDEHEASAVILLGKDKKIMKIKRSEV
>A0A4S3J7I9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus tanneri|TrEMBL
MAANNVFEGLLTFWHSYRLPVLVAVFSIVIIVWAYRKLQPKSKTAAASSVPTSPRSQSPR
KAEKETLGDIKQGTEEKNTQRLAENETLAKSASGPKRLSGKKPLKVAGRRGGSDQGAPLS
FIQPIIFFASLTGTTERYAQKLQEDLRVATQNQADPENHERGILSPQIHDLSYVDFDDYF
TTAPKPPPTSPGTRYLYCLLIPTYNIDTVLNTFLDHLNETHNDFRIDTGSLSSLAGYAVF
GFGDKEGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKNDAESALKEWSHGMQD
VMADILASGGLGEGVPGSGDPLESDDEDLEDASDDNKSKSRKKAQNVVDLEDIKMAAENQ
GGSGSPIPVDFTTDGKSSALPSQLTAKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWT
KSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPEL
IFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHTE
HISSFLVCNAQHPDQLEALKRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILR
EKRHVQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQ
NVPFYEEVTAFVVALNKELERRGLQYGIAAEHAHSCCVLIASERFHVNGKWHSRIDYDRF
FELLEKEKADGTSFSPEDYMRETEEWAQWGNGGFDPNDERVYKKGKNKAIQAAPES
>A0A0Q3GRD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brachypodium distachyon|TrEMBL
MTVFRGPPGRPSALVAWWRRRPPLGFAAKVSIAIALGLSFVIVWTTLSPTSASQQISTER
TYFAAEIAEPPTASRNRTSGSHGKPHATRSSRGHKKRHSPTRSHSHRPNATPSPDATASK
TNLTEPALRPDQEPNEKGPEPVTETETEPEEEQEQEVELSVPEDNGENTGKAPKEEDEKA
PELDLVDESSELDGDEEDPEAAKRNPSKEKKKLPHLFSPAAHYHWKQCSAKSGHHYIPCV
DFDADGSQRHHERSCPRSPVTCLVSLPKEYKPPVPWPERKEKVWYENIGHPRLASYAKGH
SWLNRTGEHLVFPPEESEFKGGASHYIESIDEMAPDIDWGKNIRVALDIGCKSAGFGVAL
LEKDVITLSLGLANEQTDLAQVALERGIPATVGSLGSRRLPFPSGAFDVIHCSECNIAWH
SNGGKLLLEMNRILRPGGYFIISSRHGDLESEKGISASMTALCWNAVAYNSDDVSELGVK
IFQRPASNEEYDLRARKDPPFCKEDQNKATAWYIPIKHCLHKAPADIEERGSEWPEEWPK
RLETFPDWLGDMQTRVAADHNHWKAVVEKSYLDGLGIDWSNTRNVLDMKAVYGGFAAALS
SKKVWVMNVVPVHAPDTLPVIYERGLIGVYHDWCEPFSTYPRSYDLLHADHLFSRLKNRC
KQPIVILVEMDRILRPGGWAIIREKLDILDPLEAILRSLHWEIVMTFRKDKEGIMSTLAV
RLSRRIADAGVDARPTDAAAFDPDDLPSVPLLLLVLPTHDAGAPPPAAAFLARWLAESAA
DFRAGALLLSRVRFAIFGVGSRAYGDTFNAAARSFSRLLRELGAVEVIPVVEGDVDDGDL
EIVFEEWCGKVLRVANGEEVEDGANGESGGFDELELEGEESDYDDDDDDEEEEEVVNGEV
DMEDLAGKATARRQNGKVAGLPNGAENGAREMVTPIIRTSLEKQGYKIVGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDDPL
DIVNTAIDEHRKMVKQMKGVPGVKPELLAEGLSPRHCALSLVGEPIMYPEINTLVDDLHR
RHISTFLVTNAQFPEKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSL
HDKDQRTVYRLTLVKGWNAEEIDAYANLLNLGQPDFIEIKGVTYCGSSATSKLTMENVPW
HADVKEFSEVLASKSGGVYELACEHVHSCCVLLAKVDKFKINGKWHTWIDYDRFHELVTS
GKPFKSCDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGTAALKG
>A0A7C4WJD1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MTDTYTECVRKLKEQKYHLIGAHSAVKKCLWVHNALVYGRFCYKCKFYGIESHRCIQMSP
SVLWCWNSCLHCWRMRPQDLGVGSDNLIKLPYVDDPEFIAETAIIEHRRTISGYKGRTSA
KMFKEAMNPKHVAISLTGEPTLYPRLSELISEFHKRGLSTFLVTRGVRPDVLSSLDEEPS
QLYISLEAYDNHTYTYFNRPLIPNAWELTLKTLEILPSFTSPTVIRITLVRGFNMDDTAI
RNFKKLIDLSQPTYIETKAYMHVGRSIGRLEKENMPTFKEVMEFARKLSDAVGYAVVSYS
TASRVALLTRLEKSMIRFGDGCPKGWEDVEECEEGLSEYERVEEVI
>A0A1D8NKU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Yarrowia lipolytica|TrEMBL
MFDEILDLWHGSRLMLIPIIGLVIFIVLFDEKKPVEAENETVEKSAATTTTNTSSRALDE
KPPMAVDFTTSSSVVSSKPKRVPKTFGKGPKKLSVSLSSQVYVFYSTLTGSTERYAQQLF
EYLSTQTKKEPILLNVDYIDDLDEYFVSSKAGSVYCFIVPSYETESPLDYFLDAIKETYN
DFRIDSRPLSKVCFSVFGVGDKESWPEKFCYQAKEVDRGLAKLGARRLNPLGNGCVKTDF
ETNMVEWREHFVDALADGVVPEADDICSDDEEEEEDSKDGIVDVEDMGKIIGSSKPKRKS
AKDIMEADSCSAKEMVAKDSPTYKALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFA
FYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPKEIIDGALAGHYQKIK
MLRGVPGVSAERFAEAFRVKHCALSLVGEPIFYPHINEFVGMLHEKRISSFLVCNAQHPK
ELAAMNQVTQLYVSIDAATKESLKAVDRPLNRDFWERLQECLSILREKRNQRTVFRLTLV
KGFNAEEVENYAKMVAKAMPCFIEVKGMTYCGTSKGNPLTMKNVPYYHEVLDFVEQLNEA
VANEGLEYGIAAEHAHSCCVLIAQKRFYIDGEWHTHINYDKFFDMLEAGQEFGPEDYTSA
TPHWAQYGAEEAGFNPADVRHRRGKVVEV
>A0A1A7Y1L5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Iconisemion striatum|TrEMBL
MLRLLLFLSHITAHVASSDTNAQQEAHSSAENYLRWMWTHRLYVYSAAAVVFGTWFLLKV
THKQIKHTESSGPNSHKAAKTTSNRDPESHVSGVKIFFGSQTGTAKGFAEELSEETEALG
ITAEVVDMRDYDPDDRLADECVGRSVCVFLVATYMDGRPTENAAWFCKWLEEASTDFRYG
KSYLKGLRYAVFGLGDSVYVGHYNTVGKNIDKWLWMLSAKRILTRGEGDCNVVKSRHGNV
QADFQAWKVKFLSRLQALAKGEKSCSGNCKSGGSCKDQKHKRDEEEKVSSPDTSSEVDRM
ESSSDEDESGLADERSSGSVVDVEDLGNIMTSAKKAKSKEQDEDEGQMVKMNGVKKSEDD
EERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQESLEKHQNMIRQFRGVPGVKAE
RYEEGLDIKHCALSLVGEPIMYPEINAFIRLLHRHRISSFLVTNAQFPEEIRNLEPVTQL
YVSVDASTKDSLKKIDRPLFKDFWSRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMMAYA
ELITLGQPDFIEVKGVTYCGESAASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEH
SNCLLIAHMKFKVNGEWWTWIDYERFQELVRVHEESGGQRSFSALDYMSRTPSWALFGAQ
QQGFDPADTRFQRRHKTKDLSGC
>W2GNF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora parasitica|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A7C4NMI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MVIGKTMQNTLSRNDLDVLRKQKYHIIGSHSAVKKCYWVHKTLTERMFCYKAKFYGIESH
RCIQFSPSILWCLNSCAHCWRYRPSKWSEFPGHVDDPEFIVETAIKEHRRTISGYKRYPN
VEPKMFEEALNPKHVAISLTGEATLYPRLSDLIEEFHRRDLTTFLVTRGVKPEILANLAE
EPSQLYVSIEAYDDESYKKFNNPVYTDLWKKTLETLELLPSFTSPTVIRITLVKGFNMHP
KAIEGWSKILSLGEPTFIEVKAYMNIGTSILRLSRYDMPSHEEVKCIAVDLAQKIGYNIV
SESIPSRVVLLSKIDKPFIRHGNAPISWYDKDIGDEYSGEYGALNEFM
>A0A2L1CBP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPEQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPETVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYLDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILGENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A843LC29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp|TrEMBL
MHSEACNVLRRQGYQFITPASSAAVKPCMWCKRALKGGEMCYKAQFYGIESHRCVQMTPT
LRCNQRCLFCWRSFEHEVVEEEECPPEVIIANLRRAQKKALAGYKVSPYVTPERFAEALN
PTMVAISLSGEPTCYSRLPELVDGLNAEGYTTFLVSNGTRPEVLGRCRPYQTYVSLDAPD
RETYLRLCRPKEDYWDLVLESLAGLAGRRSAIRTTLVRGYNDFAPERYAAIYQGSGARFV
EVKGYMYLGYSRNRLLREQMPEHAEIREFSEMVSQHSDYFIKDESPLSRVVCLERDV
>I0FT30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca mulatta|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A8C0Q9F1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus familiaris|TrEMBL
MNFVQLFILKGKKSQEKSVPKATGDLMTNGCISLQNKEVFVSGVKIFYGSQTGTAKGFAT
SLAEAVTSLDLPVAVINLKEYDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWL
EEASSDFRFGKTYLKGMRYAVFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDC
DVVKSKHGSIEADFRVWKTKFLARLQALQKGEKKPCDGNCKRGQCESSVEEEPSESTSEE
ESGTEDHQNLNSVVDVEDLGKIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSERRTMITP
ALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVK
HCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTK
DSLKKIDRPLFKDFWQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPD
FIEVKGVTYCGESSASSLTMANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHK
RFKIGREWWTWIDYNRFQELVQGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDT
RYQRKNKSKDISGC
>A0A8B7GAG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microcebus murinus|TrEMBL
MWDLSSPLISLWINRFYIYMGFAFGISLWICVQIVIKKQDRNSQEKSVSKRTRDLMTNDH
SSLEKKEIFVSGVKIFYGSQTGTAKGFATILAEAVTSLDLPVAIIDLKEYDPDDHLVEEV
TSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVFGLGNSAYAS
YFNKVGKNIDKWLWMLGAHRVMTRGEGDCDVVRSKHGSIEADFRAWKTKFIYRLQALCKG
EKKKSCGGNCKKGKCESNQHGSEETEPGSHTPDDLHPRDTEEEEPGENTSEEEFGTEDHQ
GLNSVVDVEDLGKIMDRVKKEKKEKEQQEEKTSLFRSTGKNEDGERRAMITPALREALTK
QGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDQPEVILKEAMENHQNMIKQFKGVPGVQAERFEEGMTVKHCALSLVG
EPIMYPEINRFLKLLHHCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLKKIDR
PLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVT
YCGESSASSLTMANVPWHEEVVRFVRELVELIPDYEISCEHEHSNCLLIAHKKFKIDGEW
WTWIDYNRFQELIQEYEDSGGSKTFSAKDYVAKTPHWALFGANERGFDPKDTRYQRKNRA
KDISGC
>A0A3F2RXW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora kernoviae|TrEMBL
MPLWSPAASAGVSLLLMATVTVGVLYYLSIHPPTSSNEAASVASPKRKTKAQRKKINKVN
TKDTNEPKPMPVRILYGTQTGASKTMAETLQKTLFALNISGFHFQTSVVSMKDYDQDNLE
QETIVVAVLSTWTHGEPPEDARMFCKWIQDMTQDFRVSKSWLSGVQHAVFGLGNAEYDED
YGTAAKNLENDLSDLGSPGLVALGLGDDNVDQFKQFDTWMDNLVAAMCEYSSERAVAALA
KSDSPVKTAQSNKKEWLSQKEFRRQKRAKKAQEAAANGESVELNEEDMMNEQFLVDEFSD
DEEQSTQNANDDSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAV
KLCRWTKHQLRGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWK
TDDAETLVKGSIERHQGMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFC
KQLHQRHISSFLVTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLA
CLEELKHKGQRTVYRLTLVKSYNMKELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTM
KNVPWHEEVRGFCSALCDRVSGDYALASEHSHSNCVLIAKKKFCREGVWHTWIDYERFHE
LVTKFYEDGTTFTADDYTAPTPFWAVYDSEEQGFDPVETRFRRTKDGKVVEFQYQSTESG
CG
>A0A815I8Z4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTVDLYILAAGSALTGLVFYFFAGAEWSLWHLFTIPLYTFVFIVFLSLSIIKRFKSSSKP
SESLTKIIPQEKNGITIVFGSVKGNCRTFAQSTYDKLSNELNCQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDGTPPPSAKWFVLHLQEAATDFRVSKNELEKLTYAIFGCGNS
FYDDNFNKVATELDRCLSELGAKQFIPTELADENSGKSIYGGLEGHYSKWSSQLKSAFQS
PKTEKCDCSNENSISCCQSSTNNDHSIEKKQNGEQSRIESDDDDEGGGCKDGDDDIMDLE
DMGDYMETHSPNKTAKGPPKEMITPIIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVDGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A0A9XAA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lygus hesperus|TrEMBL
MMLEFLLSINFLGHFLIASVIALLIFKNFCNLYSAETSEPILPTAKRQQKENERQRPQSL
YRNIDTNFRCIEVYFATEYGNTKKLCEKLVEYFTTTKSIDSVLIDLSNIEPEDVLHSKNA
QRKCLSLFVLPTVTDGQPPKAAKWFCKWLSDAATDFRIDKQSQAHVSYAVFGLGNSVYAE
NFNIVAKEVDENLAQLGACRVCKLTLGDEDTSESQNGGLEADFDAWTKVIENVVWSQCTP
PYEVLDTRANEVETSSEEEDVVDIEDLVKPKSKRTNSKSEGAKEMITPQLRGVLTKQGYK
LIGSHSGVKLCRWTKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNP
VGTEWKWKMDDANTILRGALENHYNMIKEFKGVPGVLPEKFAEALAVKHCALSLVGEPIM
YPEINKFCRLLHEEGISTFLVTNAQFPEAIRAMDPVTQLYVSVDASTKESLKKIDRPLFK
DFWERFIDSLKALSEKTVQP
>B7QN38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ixodes scapularis|TrEMBL
MIEIVLCIVFAAPANGRGKCAPRKAFPSLLFYEVKSKGLCIFIVSTYVDGGPPDEAVWFY
DWLKDTYADFRVHKYFLQGLDYAIYGLGDSAFNDNYNKVARDIDFWLSKLHARRVVPLCL
NDESVDEGKYGTGKFGAWKSQLLAQLRLGAKGATQFDAPEEKPAAYETSSDEEGGGDLID
LEDLGTVRIASKNKAKAEGAAGQPKDMLTPPVRESLTKQGYKLIGSHSGVKLCRWTKAML
RGRGGCYKHTFYGIDSHRCMEATPSLACANKCVFCWRHHTNPVGTEWKWNMDPPEMILDA
ALESHYKMIKEFKGVPGVLRERLAEGLAVRHCALSLVGEPIMYPEIGRLVRLLHARRVST
FLVTNAQFPEALEALGPVTQLYVSVDASSREALKRIDRPLFPDFWQRFQDSLIALARKGQ
RTVYRLTLVKEWNMEEMQGYANLVELGKPDFIEVKGVTFCGESKGSSLTMGNIPWHEEVL
SFVERLAALLPDYSIASEHEHSNCVLLAHHKFRVDGVWHTWIDYERFHELVQRHYESREP
FGSLDYAAPLPPWATFGARERGFDPSDTRMLRRSRKDVGGC
>R1CW77|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Emiliania huxleyi|TrEMBL
MSLLRLDLLPAPLLAALSIFALTLVYVIFGAAPSPPEASAAASAADSSAAAAAGRPASGR
QPVVVFYGTLKGGSRRLAERLAAALREAGVAAETVSLIGYDTDGLTSLECAAFVIATYEG
GVPPPGCEAAVDSLASAAADFRGTDLDLRSLRFSVFGCGNSEYPRRDFNAAARRLDGSIR
RLGGVRVARSCWGDDIDNRLSEQFGEWSARAVPSLAAAARPRSGADAAAKRGAARDGSAG
AEQAAGGQDGRAVGLEDENGDEEDEGEGEEDGEEEDADQGGLSDSGGLVDVEDLGARMSK
RAAAAGGEGRKKMVSESLRKSLTKQGYKIVGSHSGVKLCRWTKAMLRGRGGCYKHTFYGI
ASYSCMEATPSLACANKCVFCWRHHDNPVGTSFRWEVDDPHELVEGFEREHLKMVKSLRG
AGRGWAGVDRGGARVGILPERLEDALRRVRHCALSLVGEPIIYPRINAFLAELHRRRIST
FMVTNAQFPKEMEQLVPCTQLYISIDAPTREQLKAVDRPLFSDFWERFNECARVHRQRTV
FRLTLVNGWNDSELDAYAELVRRGAPDLIEVKGVTYCGDSKASPLAHESTAPLLHCPFHH
EVRAYCERLAAAAGPGYTIASEHAHSNCVLIAADAFCRDGVWHTWIDYERFFDLYQDWQA
NGTEFTAAEYAAPTPSWAVYDPLATDGGFDPAERRVAGRGAAKRAASGAAAS
>A0A843EJV5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilaceae archaeon|TrEMBL
MDEDYRNLLIKQQYRIYKDHAAVKLCHWMKESMLHERHCYKQDFYGIESHRCLQMTPAIN
ECSHLCTFCWRVQGSDFEVTDWAEPKEMLDALINEQRKLIQGFKGDPRCDPKRFQEAMNP
NQVAISLAGEPITYPYLSDFLKECHSRGMSTFLVTNGTYPDQLASLDELPTKTYVTVAAP
NKEVYLRVCRPKIKDGWERLMRTLELMPSLNTSTVVRHTLVKEHNLGWVDEYAALDRIAD
PELIEPKGYVFVGGSRQRLSMSCMPSFQEITDFANQLGSRVGMEIIRKREDSRVVLLGHP
GQELDVRKSYQLRV
>W9KKZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum Fo47|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A4Z1J9G8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botryotinia convoluta|TrEMBL
MAYDSWISRPIWSYEIDDIVALWHLYRIPIILTTATILILVRITLRPRTVREKLSASPLP
SSPVLPAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEENLQTGPEKIQPLVFFSS
LTGTTEKTAYSFVESIRGDLSGRAIGQKIQFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGMGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NTPGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGDDKVAENSTKDELAF
>A0A2H6JUF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon BMS3Bbin15|TrEMBL
MLNFIAWAMENVKEILEKQGYSIIGTHSAVKICHWTRERLMRKRSCYKAKFYGISSHRCI
QMTPSFAWCQHSCLFCWRPVEHTLGTDDIKEPQEPSYIVEASLEAQKKLISGYGGEKERV
TQQEFKEANSPAHVAISLAGEPTNYPYIGELIEEYKRRKMSTFLVTNGMNPTRLEEVNPT
NLYISLISPTEEIYRRLNRPKIKDGWERLHESLEIFSTRKTRKVVRITLVKGYNLEVPEL
FSKLIEKAEPDFIEAKGYVHVGYSRKRLERSHMPSYEEVNSFSDRLSRVTDYTIKDSSKD
SKVFLLSKG
>A0A671PQP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus anshuiensis|TrEMBL
MVNILSSQVCKLYSRAFTGVLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGVCFTMNMLF
KKKKTVDPVSPWLYKSAKKQDLSAETEKVIHVSGVKVFYGSQTGTAKGFAKELAGDVSAQ
GIQCDIIDMKEYDPEDRLTEECTSKMICVFLVATYRDGQPTESAEWFSKWLEEASTDFRY
GKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGS
VQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGSCKNKKKHKKEAEDSHSLAEKNNSEE
ELMESSSDAESSSEEEKSHGSVIDVEDLGNVMNHMKKAKVKTKPAPPTLYIARYKLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEW
RWKMDPAEKIIQEAVENHRNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEIN
SFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQR
FLDSLRSLGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFIEVKGVTYCGESSASS
LTMANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDREWWTWIDYERF
QELIQEYEESGGTKSFSAMDYMAKTPSWAIFGAQERGFDPSDTRFQRKNKTKDISGC
>A0A830GJ46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicroarcula pellucida|TrEMBL
MSESDDGPKQVSDPAYHSENHTAAQTCGWTKNAIQGDGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQKRLLSGFGGNENVPRDVFEQA
MEPRHVAISLDGEPTLYPYLPELIEEFHDRDITTFLVSNGTNPEMLAECDPTQLYVSVDA
ADRQTFDATVKAVEDDAWDSLVDTLDVLAGKDDTRTVVRTTLVKGHNMHHPEWYAAMCDR
ADVDFVEMKAYMHVGHSRGRLDRDSMPSHEDVRAFTEEMQAFLPDHDVLKEVEESRVAML
AEDEQTWVPKLEKSSEFWERDSHVEY
>Q4RFU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetraodon nigroviridis|TrEMBL
VSAVKILYGSQTGTAKGFAKELSDEVKALGIPAEVIDMKDYDPDDQFAVECTTKSVCVFL
VATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYTGHYNTVGKNV
DKWLWMLSGKRIMTRGEGDCNVVKSRNGSVQADFLAWKIKFLKRIQALAKGEKKICSGNC
KTEGKCKSKRKVKEQENAALQNNSSEGELIESSSDEDESGLQDENQSGSVLDMEDLGNIM
NRVNQKKVCLPWATIAIYLFFLTKSEEDGRGNDQTVKLSRLNGLKKTEQGEDVREMITPS
LREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWRWKMDPPEKILQDALEKHQNMIRQFRGVPGVKPERFEEGLEVKH
CALSLVGEPIMYPEINTFVRLLHTHNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKD
SLKKIDRPLFKDFWPRFLDSLKALGEKVHEICRVRQRTVYRLTLVKAWNVEEMQAYSELI
TLGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEVACEHEHSNC
LLLAHTKFKVDGAWWTWIDYERFQELVRIYEETGGQRSFSALDYMAKTPSWALFGAQEQG
FDPADTRFQRRSKPKDISGC
>A0A8H5RY93|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium tjaetaba|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKAEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEEDVTRPVAPL
VFFSSITTKTAKIAEAYIEDFRGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTQKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVGDKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A520JUH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MLTSSNFESLLKKHGYHTAGSHSVVKTCLWLNKSLRGEGKCYKFQFYGIASHRCVQMTPT
MQCNQKCLHCWRPTEIDVPETGWDSPELIVEESLKAQQKLISGYGGADIIDKTLWEEAKN
PRHVAISLAGEPTIYPYLDQLIDTFHSKNMTTFVVTNGTYPAMVEQIKPTQLYLSLNAPD
EDTYRQTCNPQEEGLWEHICESLDILQEKQTRTVLRITLTEGLNITNPEGYAALIDRASP
DYIEIKAYMHLGFSQKRLERSAMPTHQRIREFSEKIMQYTDYKQADESPISRIVLLSKNG
YVKKIV
>A0A7K7A1H6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothoprocta pentlandii|TrEMBL
LDVSMDPQNYFYTCLVSLWLHRFYIYSSLALGISVWICIQCFANKTRRKKCNGNPASAEE
TEGKLVNGYATSKAKEVYVAGVKIFYGSQTGTAKRFAESLAEAVISLNLSAEVINMGDYD
PDDSLTEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVSDFRFGKMYLRGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSRHGSIEADFEAWKTKFL
SRLQALCKGEKKPCSGKCKKGKCKSQGKQSKESSDHGHGTSEYVNAEAEEFFETTSEEES
DAEKAGDANSVIDVEDLGEIMSHVKKVKVLLASTEDMMVLSFVLGGALGFSSRFLPHQNS
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRLEEAMTAKHCALSLVGEP
IMYPEINRFLKLLHQQNISSFLVTNAQFPQEIRNLEPVTQLYVSVDASTKESLKKIDRPL
FKDFWQRFLDSLMALSEKQQRTVYRLTLVKAWNVDELKAYAELVSLGKPDFIEVKGVTYC
GESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKINGEWCT
WINYDRFQELAQDYERSGGAKTFTAADYMAKTPHWALFGAKERGFDPLDIRYQRKNKTKD
VSGC
>A0A7J4EJ79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MDNQLHFVSTDYTSALKKQGYHIVGRHSAVKTCLWLNKSLRKEGVCYKSIFYGIQSHRCI
QMTPVLNCNQSCRYCWRPIEIPVPEITELDSPSEIADWVIKEQLRLLTGYGGSKTTDMQK
LKEAQNPKHVAISLIGEPTLYPYLPELINEFHKRHKTTFVVTNGTNPEMLKKINPTQLYM
SLNAPDRETYIKTCNPMQEYWNKITESLKILQDTKTRTAIRVTLVKGLNMFNTIGYANLI
KIANPDFVEVKAYMHLGYSRKRLSRDAMPLHSEVYDFAENIANALDYKIACDVEISRVVL
LTKNGTIQRLCYS
>A0A849QXT0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MNNLSRHQLLPMSTLPEHQLELFKKMGYHIVGTHGAVKPCLWSGRSIKGKGSCYKSQFYD
IQSHRCIQMTPFLGCNQSCLHCWRPVEHPVDTPAEWDSPEEIVGGCITEQRRLMSGYGGL
DDADKVKWKESLEPKHAAISLAGEPTLYPFLPELVREFHKQGLTTFVVTNGTKPDVIEII
RPSQLYMSLDAPDRQTYIRSCAPDHQDQWERILESLEVLSHHPCRIAIRITLTKGLNFKD
APGYARLIELAEPDFVEVKAYMHLGYSRKRLERDAMPQHEEILEFTSELARELGYHMADD
VELSRVALLSREEKVTPVIL
>A0A1R4A9V7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Babesia microti (strain RI)|TrEMBL
MKSVYIAWAGDGTSTLAFAQRFWGILQNTNLEPINPGKSNTHFITCDELVTIDDDSGSLS
GLIGTDKEDSLFILFISTSSCGSPPKGAQIFYKQLEILAENTHKTENLLKEVSYLIVGIG
DSQFGDEYFCLSSLKINNFLQKLGATQMSKQITIDRRFHELYAIENDVFDKILNAITNHG
SGESVWHSNDIIDSVDDIEDFGTKTAEMLSALQKRNLIKEGYRIIGSHSAVKLCRWTKSH
MRGRGGCYKHTFYGIISSRCMEMTPSLACANKCVFCWRHHTNPVGTRWKWNTDDPQFIAK
QAEEQHVKMVKELKGVLDIKSDRFEEAQHIKHCALSLVGEPIMYPHINQLIDILHTRQIS
TFLVTNAQFPDLLNTLKKVTQLYLSIDAFDKESLKKIDRPLFSDFWQRFQQSISILATRG
ERTVFRLTLVKQFNMTEHANELQDLAMLVSLGKPCFIEIKGVTYCGVNSDITMANVPWHD
QVVLYAHALISASEWVGTNYTVICQHRHSCSVLIASNKFFFDGKWHTWIHYDKFHQLVNS
GKDFGPLDYAAETPEWALLDSKHQGFDPEDTRWYRNGSKASNGVNRRKNDCGNCNCNNS
>A0A662RSS9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MEPKATLKYDEEDGTRKTLEKQGYHFVGLHKHSAVKTCLWLWKSIRGEGNCYKGKFYGVS
AHRCVQMTPSIFCNQRCVHCWRPLEAFTIGRETKLMKQPTEWDSPEEVVDGCIKEQKRLI
SGFKGSPKTNRTAFMEAEVPKHAAISLIGEPTLYPYLKELIQEFHSRGMTTFVVTNGTNP
DVLREISPSQLYLSLNAPDEAIYKKVAHADYWSRIKESLEELRMKKGRTRTVIRITCIEG
INMVNPGGYAELLKIANPDFVEVKAYMHIGYSRKRLPREAMPSHSRVKQFASEIEEALAS
ICDYGYKFEDESEKSRVVLISVGHERFLQLNHRITQISTRK
>A0A533UJU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGETIESDNEIIQITPKLVSQLKKAKYGVSDHSTVELCHWTKKSFKGEGDCYKMKFY
GITTHRCMEFSPAGMYCENRCVYCWRPMEFYNSMEMRPDKVASPEEIVTNLMEERRKLIM
GHYGDPRQDRKKLDESLLPSHYAISLSGEPTMYPQLPQLIKYLKTLPETKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAPDEETFQLVNKPRYKDAWERWNTSLEMLSKINTRTVI
RITLIKDYNTSEELIPKFAQILKRANVHFIEAKSYMHVGRSTNRLEYSNTLEMPEVRHFA
DEVVKQSKIYSVMDESAISRIVVLQNQNRFIDRWIPAHANAT
>A0A533WTX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLIGERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRILVLQNQKRFMDRWIAAYANTN
>A0A533U8B0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSDEYISHTGTQNLIQISPLTKAKLKKAKYGVYNHSAVELCHWTKKSFSNEGTCYKHK
FYGISTHRCMEMTPTAMNCENRCIYCWRPTEFYDTLEMPENLVDEPDMIINNLLEERKKL
IVGHYGNTKTDKKKLDESLFPEHYAISLSGEPTMYPKLPNLIRYLKTLKNTKSIFLVTNG
QEPEMLQRLIDEDSLPTQLYLSTNASNKKMFTLVNRPRYKDAWDRWNKSLELLSKMDTRT
VLRMTMIRNFNNSTNYIHEFADLMRRGDPNFIEIKSYMHIGMSTQRLENSDMLEMDEIRS
YSHLLSKSLGTFTIMDESEISRIVVLQNLKRYTERWIEAYEKPIIQ
>G8JP40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582)|TrEMBL
MAKYGELDSSISNILVLLGVIFTYLLDGGRVSIAITAVILYIIVQLESGDGQEASVIAVE
KDSQKVKSSVCNSSGSGGCCSTKTGAKTGAKKKGCCGGKCKSKSVDAVREIAVTSVTGQV
SSGSYPIAIDFTNAFNTKKVKSKTVSKKVRKLISSEVKTRSRDDLVKQALTISNEKLMAS
QVFVFYSSLQGTAKRSAERVTEILSKTYSLKLEPILKNLDELEDFEQYFVDVPCENALYV
LVIPSYDTDSPLDYFLDCLEEYFNDFRIDKYPLRKLVGYAILGIGDSESWPEKFCYQARI
ADLKIAKLGGRRVFPVGEICMKFGGDSEVDSWARLFADTLQDDEPILYEYDESVEDEPDE
SLEQSTGEPLVDLEDIGNSSVAYDSNTAIKQMVAVDSPTYKNLTKQGYSIVGSHSGVKIC
RWTKNDLRGRGSCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKNWRWELDE
PEFILENALKAHYSKIKQMRGVPGVIAERFSKAFEVAHCALSLVGEPIMYPHINRFIELL
HEKHISSFLVCNAQHPEQLEILGKVTQLYVSIDAPTKQELKKIDRPLYKDFWERMLVCLD
LLKTTQSHQRTVFRLTLVKGFNMADVSSYADLVKRGLPCFIEVKGATFCGSSDANGNPLT
MQNIPFYEECIKFVKQLSSELQRRGLGYEIAAEHAHSNTILISSTKFKKNGDWHTYIDFE
KFFELLNSGASFSHVDYMAKTPEWALFGNGGFAPGNVRFYRKKKNQEPPIAEISSSTGTT
ALTP
>A0A6A2WCQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hibiscus syriacus|TrEMBL
MAPSSLSTHLTLLTLLSASTFYFLYKSRRRLKPFKQLPLNSNPRKGKLFFITQRGTSKAL
AQRLLKVLSSNNIPFELVDPQNYEPEDLPKESLIIIIASTWEDGNPPHNSKFFVNWLAEI
STDFRAGSLLLSDCKFAVFGVGSRVYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVDGG
ALESFFEEWGQKVVTVLKGGLVMENHNDIVYESDVDSLESDDDGGGGGGGDIVDLEDIAG
KGPSRKKSVNVVETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLRGR
GGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAID
LHTKMIKQMKGVPGVTQEKLMEGLSPQHCALSLVGEPIMYPEINELVDELHRRRISTFLV
TNAQFPEKIKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLKTLDEKHQRTV
YRLTLVKGWNAEDVDAYFKLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVRDFS
EALALKSEGEYKVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYENFHDLVASGRPFNSED
YMAPTPSWAVYGAEEGGFDPDQSRYRKERHHKSKR
>A0A367IGA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFYKLEETLELLPSLDTRTVCRHTLIKHESMGYHDDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEVLEFSQKLAPMVGREVLSDRRESRVALIGK
EMIPVELPVANTELPKDLGIAKPQRFLLPQA
>A0A2B7WSA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Helicocarpus griseus UAMH5409|TrEMBL
MTGDVLEISAQGLLSWWHRYRLPILLLVPVAFAAAQLFPGNYTKPEIPPSPPPSNEQAKS
NARHTDNLSRNDPAGPSAKRDESRSSSADSNKRPKQPVTGPKRVHGTKPTKNGIKSQAIT
SGSAQDVAIQPLVFYASLTGSTEVYAKSFCDRLQESAQKIKENRGGTLLTPVLHDLSYVE
LDDYFISAPKAPDAAPNTRFFYCILIPTYNIDTMINNFLGHLDETHHDFRIDTSALYGLA
GYSVFGFGDREGWPTEEDGFCSQAKEVDKWMAKLTGRKRAYPLGMADVKGDNVRNVLGEW
CDGLCDVLSDLLRSGGLGEGVPGSGDPVESDEEDVDDDDNESSKKEGKEQIMDLEDIKFG
ASNGKKSSADPLPIDFTTQSKTQSSKPAPQLEMVPTSSPTHAALTKQGYTIVGSHSGVKI
CRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVD
PPDLIFNGVKEGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLEL
LHNEHISSFLVCNAQHPDQLAALHRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCL
DILREKRYYQRTVYRLTLVKGFNVDEEAKGYADLVEKGLPCFVEVKGVTFCGTSTSAGAG
LTMQNVPFYDEVVTFVVALNAELSRRGLGYGIAAEHSHSCCVLLASDRFYVNDRWHTRID
YDKFFALLEKEKSDGTPFLPEDYMRETEEWALWGNGGFDPKDTRVYTRGRNKAKHNAALK
EAEANAVSVEG
>U3E2W3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callithrix jacchus|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAFSISLWICVQMVIKKQDRNIQENSFPKTTQD
LMRNGYVSLQKKDIFVPGVKIFYGSQTGTAKGFATVLAEAVVSLDLPVAIINLKEYDPDD
CLIEEVTGKHVCVFLVATYTDGRPTESAEWFCSWLEDASRDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVSRGEGDCDVVKSKHGSIEADFRAWKATFISQL
QALQKGERKKSCGGHCKKGKCKSQQHGSEEREEGSLEQDELHHRDTEEEEPSEDSSEEEF
GGEDQQSVNSIVDVEDLGKIMDHMKKEKREKEQQEAKTSLLVNMGRNEDGEGRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTAWRWKLDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMAVKHC
ALSLVGEPIMYPEINSFLKLLHQRRISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGSEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A3P9LCE6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
MAKCLMVVLFFARCAFASDVNAPQTGSSLAENYLALLWHHRLYLYAAAALVVGLWVSLKV
ALSRKSGEKDAVLSGAKKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKALGFPAEV
IDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYGRTYLK
GLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQADFQ
AWKGKFLSRLQALAMGEKKICSGKNCKTGSSCKSKKEEEEASKETGSEVELVESSSDEGE
SGLTGEKRSVVDLEDLGNLMKNAKKAKGKNGPQQDGEVVKFSKLNGVKKIDDDGERREMI
TAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALDKHQDMIRQFRGVPGVKPERYEEGLA
VKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLEPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYAELIALGQ
PDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLSAMLPEYEVACEHEHSNCLLIA
HKKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDYMARTPSWALFGAREQGFDPA
DTRFQRRNKTKDISGC
>A0A2U1NCM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Artemisia annua|TrEMBL
MPTTTVTTHLTLLTILSAATLYCLYKSHSLRKPKHPKIKKPLNPNPNTPLNPKPTKTPKI
FYISETNTSKNLAKHLYKILKTNNLKFDLINPETYEPEDLHSEDLVLIIASTWQDGLSPS
NGVFLSNWLNESVSDFRVGSLLLKGVKFGVFGVGSRSYGEERFNKVGRGFSSGMKALGAV
EILPICEGDVDEGDLDEVFEKWCEDVVRVLKSGVLENGENEEVGYEEEGSEYEDYESEEE
EVEEEGIVDLEDIAGKAPTKKDLEKGAGMRNGKKNGVKEMVTPVIRASLTKQGYKIIGSH
SGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSW
QWQMDDPLMIVNSALDQHKKMIKQMKGVPGVTAERLSEGLSPRHCALSLVGEPIMYPEIN
TLVDELHQRRISTFLVTNAQFPEKIISLKPITQLYVSVDAANKDSMKAIDRPLFGDFWER
FVDSLKALKDKQQRTVYRLTLVKGWNTEEVDAYSRLFSIGNPDFVEIKGVTYCGTSATSK
LTMENVPWHADVKEFSEALAQKSNGEYEVACEHVHSCCVLLAKVDKFKVDGQWHTWIDYE
KFHDLVASGKPFDSNDYMALTPSWAVYGANEGGFDPDQARYKKERNHKTKG
>A0A497SZK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MISENLRRELEKKHYKLFNHSGVQICEWTKKSLRGEGVCYKEKFYGIDCHRCMQFSPSVV
FCNLRCLFCWCPNELFINKFPEEIDEPEEIVENLIEQRKKLLSGFGGSVKNKKKFEESLE
PNHFAISLSGEPTLYKKIVELVDYLTERARTVFLVTNGTNPDILQKLKKKKNFQLYLSLS
APEKEKFEKICRPTEKNLWDKFNKSLEIINKFKGRRVVRLTLIKGLNDSDEDLKGFLKLI
EKGNPDFVEVKSYMSLGYSKKRLGDEKMPDFEEVKKFALKISKKSNYKYEDESKDSRIVL
LKNKDSKVVNKFN
>A0A7R9JX79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema genevievae|TrEMBL
MITIFGVPFFGASFMPTLVAVVTIYIAWSWFAKKQNGNKICSLEAINPVTADSLSRQVVE
NGKGPLISIDDKVGLKKIVAKTRKKSCGGKGGKCCGSKKGKSKCLTIEGVIERLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEELANAPVVLSQTTEDGEIETS
GQSLCVFVLPTHAEGKPPEAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQYADH
FNEVGRSVDHWLHKLQAVRVAKLGAGDEDTAASRHGSIEADFDDWQNALMGCVEKWQAKS
NCRCGGKSQPQEERIEEASSCDSRSDAGEASDSEWDSDPSQEVKSAVLDMEELGNFSSAL
RAARKRKESEESEGTREMITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKH
SFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALEAHYKMI
NQFKGVPGVKPDRLAEGFQAKHCALSLVGEPIMYPEINKFVKLLHQKEISSFLVTNAQFP
EAIREMSPVTQLYVSVDASTKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYRLTLV
KAWNVDELENYAKLVEIGKPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQKLADL
LPEYAIASEHEHSNCVLVAHKKFQVDGEWSTWIDYDKFHELVQKFYSTNGESSFTALDYM
RKTPDWAVYGSSEQGFDPVETRWHRKSNTTKDISGC
>X0AEN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. melonis 26406|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEGKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A5Q4BW91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum shisoi|TrEMBL
MASSLQSAGFKDMLNDAHDVWQQVRIPVILFAAFGLLVLRFYLHSTDEKGELKALPKVYN
TEKPQSKPMDEKKDEKKDEKKDEKKGIKQPSSESVTESKAPKSNGPRRIKGGLVKRVSSD
SANAETLVRKIRPLVFFSSITANTPNIAKEYADRLEKELQRSATGTGCSFTTPEVLDLAE
VDFDDYFITPPKSEDDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLL
GYSVFGFGDREGWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWS
EGVVDVLTMLAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLIEDSEAKPEKLKNRKNID
DVEDLGRIMKSSNPDTDTTNRTAAAPIAVDFTSYGKTTQKKTPTSAAKEMVPKNSPTYAS
LTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFC
WRHGTNPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALS
LVGEPIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRK
IDRPLHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFV
EIKGVTYCGTSTASNAGLSMSNVPFYWEVAEFVKALENRLNEKGLKYGIAAEHAHSCCVL
LASERFYVDGKWHPRIDYQRFFELLEERGPDGDWKPEDYMGEATPEWATWGNGGFDPRDE
RVDRKGRKIES
>A0A024U806|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces invadans|TrEMBL
MLVVKPSTLAAAATLAVVSASIAYVLWKQRRHENASSKAQSRKASTGCCTNNTTETSTGC
CQNNSSGHNGDDAEESNKPVAVRILYGTHTGTAKGYAVALQKKLFALNVAGYAFEPSVVD
MKDYDQDNLEHEQVLIAILSTWTGGVPPESAMVFCNWVQDMAQDFRVSKTWLKHVHVAVY
GLGNSEYDENFGKASKALSKHFSTLGASRLCPRGVGDDNHDQTAQFDTWSDHLIASLCEQ
YVILQKPATADADARNSKVAGWKSQNEFRRQKRKEKAAANGEDNEEAMWTAEDQMNEIVL
ELDQGDDSDEDGPSRRTKGNGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYKI
IGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPV
GREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIMY
PHINEFCRELHARQISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKD
FWERFLSCLTQLKAKGQRTVYRMTLVKEHNMKEIDNYVELIHMGEPDLIEIKAVTYCGKS
DASDLTMQNVPYHQEVRDFCELLCAKLGCGYALATEHAHSNCVLIAKTAFKIDGQWHTWI
DYDKFHSLIQAYVTTLLRRR
>A0A7J2U078|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MTYVENLSINPIIKALEVLKKQKYHVIGSHSAVKKCYWVHKALTEKMFCYKAKFYGIESH
RCIQFSPSILWCWNYCLHCWRYRSKDQWSDIWFQFPEGVDDPRFLVEMAIKEHRRTVSGY
KKYPNVDKKMYEEALNPRHVAISLTGEPTLYPRLGELIKEFHRKGITTFLVTRGVRPEIL
ANLDEEPTQLYVSLEAYDLASYTKFNNPISSNLWRKTLETLEMLPSFSAPTVVRITLVKS
FNMNEEAVESWARILKIAQPTFIEIKAYMHIGLSITRLSRSDMPSHAEVRKIAEILAKRL
GYSLVSESVPSRVVLLSTLDSPVIRYGNPPVTWRDIDAGDENSGEYGSSEAP
>A0A7K8KHD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lophotis ruficrista|TrEMBL
LDVSSMDMWNFFSTCLVSLWLHRFYVYSAVAFGISLWIIVQFSTAKTKKKVTEGVSAPDK
LVNGYATLQAEEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVVNMGDYDPDDC
LAEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGN
SVYVDHYNTAGRNVDRWLWMLGASRIMTRAEGDCNVARSRHGSIEADFEAWKAKFLSRLQ
ALCRGRKKPCSGKCKKGKCKSPGKQSKESSDHELQNASEYENPEAEEMFETSSEEEADAE
EAEGTSSVVDVEDLGNIMSHVKKAKVPLFQRGQNFDGWIYFLFSGYRLIGSHSGVKLCRW
TKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPE
VILQEAIENHQNLIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPIMYPQINRFVKLLHQ
RGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLRRIDRPLFRDFWQRFLDSLKAL
SEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEVKGVTYCGESSASNLTMANVPW
HEEVVHFVQELAGLIPDYEIACEHEHSNCLLIAHKKVR
>A0A7L3TSL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Uria aalge|TrEMBL
NVSMDTWNFSYTCLVSLWLHRFYIYSVVAFGISVWIIIQFFTTKTKKKGEKSNGSPASSE
GIKDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFATGLAEAVISLNLPVAVISMGDY
DPDDCLAEETTSRNICVFLVATYTDGQPPESAAWFCKWLGEAANDFRFGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLGASRIMTRAEGDCNVAQSKHGSIESDFEAWKAKF
LSWLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDQEHRASEHENTEAEELFETSSEEE
ADAEEAGGTNAVVDVEDLGNIMSHMKKAKVLLLGLSVRASDPHVGGHSDPAHWAGSLLIY
FLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCALS
LVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFVEVK
GVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSNCLLMAHKKFKVD
GEWCTWINYGRFQELVREHERSGGAKTFTAADYAAKTPRWALFGSRERGFDPLDVRYQRK
NKARDISGC
>A0A673K3U0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
FDRPQKMLFLALLSCLLYSTVGAEMSGVLNDVWDYTESYLLTVWQNRLYVYTTAAVLIGV
CFTMNMLFKKKKTVDPVSPWLYKSAKKQELSAETEKVIHVSGVKVFYGSQTGTAKGFAKE
LAGDVSAQGIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLE
EASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCN
VVKSRHGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHSL
AEKNNSEEELMESSSDAESSSEEEKFHGSVIDVEDLGNVMNHMKKAKRMEGDEEDSQRVK
LSKQNGVRKSESEEEQREMITPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCGFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHRNM
IRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQF
PEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTL
VKAWNVDELKAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVVYFVQQLAN
LLPDYEIACEHEHSNCLLLAHHKFKVDREWWTWIDYERFQELIQEYEESGGTKSFSAMDY
MAKTPSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A0J9XJY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geotrichum candidum|TrEMBL
MIDALIELYKSNRGLILALAVLILGYTLRKGANPAPVAAPAAAPIEAQKVQAKSEPVKEE
TKKQPSQSKPAKKSAAAAVPLAVDFTSISTSSALPEPAAATTRVKRMPKKFTAKASVAAE
RKLRQLQGPGGPVASVDSPVYVFYSTLTGTSQRMAEKLVADLTPVLATPPKLLNLDYVDD
LEPYFVAPEKSTNPPVYLIVVPSYEIESPLDYFIELLKETYNDFRIDSRPLAALAGFSVF
GIGDRESWPEKNRYCYQAALVDKWMSKLGARRVFPLGTGCVKTDLEDSLLTWRTHLSESL
RDPVPVMEPESIVDSDDESEDETSDNSDGSGGSSSTLVDVEDIGGSIAATSEARKGASSS
TNVKTKEMVGKDSPTYNALTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSH
LCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWQVDPPEKIFEGAKAGHYKKIKQMRGVPG
VVADRFTEAFTVKHCALSLVGEPIFYPHINEFVGLLHGEHISSFLVCNAQHPDELERLGR
VTQLYVSIDASNKEDLHRIDRPLHRDYWERFQKCLSILKTKKSQRTVFRLTLVGGFNMED
ACDEYAELIEKGEPCFVEIKGVTYCGTSKGSSLTMKNVPFYEEVKLFVETLNRALAKRGL
EYGIAAEHAHSCCILMAQNRFKIDGVWHTVIDYKRFFELLESGADFGPMDYIAPTAEWAH
YGANEGGFSPDDVRHRRGKVVEVAA
>A0A315VMB7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gambusia affinis|TrEMBL
GFASELSQEVQTLGIPAEVIDMKDYDPDDRLADECVSKSVCVFLVATYTDGRPTENAEWF
CKWLEEASTDFRYGNSFLKGLRYAVFGLGDSVYVGHYNTVGKNVDKWLWMLSARRVLSRG
EGDGNVVKSRHGSVQADFRAWEVRFLSRLKALARGEKKSCSGNCKSDASCKNRKKHGAQE
EEEENGSEVELIESSSEEDESGLSDEKTSRSVVDVEDLGNIMNNVKKAKKQRTVYRLTLV
KAWNVEELQAYAELIALGQPDFIEVKGVKEDQGDGQMVKLSKQNGVMKTADEEERREMIT
PALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NRCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLAA
KHCALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPEEIRNLVPVTQLYVSVDAST
KDSLKKIDRPLFKDFWPRFLECLRALGEKMLPCCNAPESIGGLMATAGVGAVMKPQWLLQ
TAALCFIFRVGYKCLIINHLKSYFSIYRCVAVLPASCLTAVLLYSTWPPAIPPFCRRFGS
CQSCVSVSDSERRQLEISHLPAAADQLSSSLLG
>A0A2J6W2R0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldisphaera sp|TrEMBL
MAELKTEDIYQALNERLERQGYHLIGNHSSVKKCYWNHAAIAEHRFCYKSKFYGIESHRC
IQLSVSNHWCWNACTHCWRLRPQDVGLEWNETKMPYNDDPKFIVENAIKEYRRIMSGYKG
RQGTDMKMYQEAMNPKHVAISLTGEATLYPRLGELIKEFHNRGISTFLVTRGIRPDILAN
LEEEPSQLYISLEAWDKESYNLFNKPLVPRGWELTLETLGMLPSFSSTTVYRITVVKGFN
DSDEAIKGFAKLIKLGLPNYVEVKAYMYVGASKGRLTRENMPNYDEVKEVAKKISNESNY
PIVSESVPSRVVLLSNMEKPIRYGNGMPMGWSSVEEEESPGEYDDEP
>A0A446UNT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRTLRPSPSPSSSPAPAAAAP
TLLYASATGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEEDGVDGETNGFDGLEGEESDYDD
DDEEEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLEKQ
GYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGE
PIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRP
LFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTY
CGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGK
WHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAAL
KG
>A0A4P9ZD45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metschnikowia bicuspidata|TrEMBL
MDLATAIFGTCAVLYVLSGHRTSLLAAAVTAFLFYRRKTASVPPRQMLITEVDFTHSFPA
GEKCPAPAPASVPTLVRKVVSRRARSPKLFSGTKRGALSLTQSTIRLVDSPMYIFYTTLT
GMSKRVAEMLRDRVCALESRTAATTLLSLDDDVGDLEEYFMKVPQKDHAPLYVMVLPSYE
TDSPIDYFLEHLQDTYQDFRVDKYPLRALGGFAVLGLGDSESWGGNLFCYQARLADRWLA
KLGAQRLFPVGQNCVKHHELARATEWMDHFVALLEDKEPFYLDYSVDDSDAEDVADSSED
VVDVEDMGRVIAAAGGKISSSDGLKQMVAQGSPTYRSLTKQGYTIVGLHLGVKICRWTKS
AMRGRGSCYKYAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWKVDPPETV
FEGALAGHYLKIKQMRGVPGIQMERFEEAFQVRHCALSLVGEPIFYPHINEFLGMLHERR
ISSFLVCNAQHPDHLARLNRLTQLYVSIDAPTKTDLKKVDRPLNLDFWERLMACLDILRT
TQAHQRTVFRLTLVKGFNMGDIASYADMVERAQPSQIEVKGATFCGSSNTNANPLTMQNI
PFYDECKTFVEQLVTELQARGQRYALAAEHAHSCCILIAHERFRIDGEWHTHIDYERFFE
LLDAGVPFGDMDYIRKTPAWAVWGSEEAGFSPDDTRYDRKAEKLRKRLEREERDDVQ
>A0A2P6PYN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rosa chinensis|TrEMBL
MSTSSARARLALIALLSATTFYCFYKSRRLKQLSLNPNPSSSPPRKGKLFFISQTGTSKA
LAQRLLKLLASNGLAFELVDPSSYEPEDLPKETLVLIVASTWDDGQPPPSAKFFTNWLAE
SAEDFRVGSMLLSQCRFSVFGVGSRAYGASFNAVGRDLSKWMRALGAAEILPVWEGDVDD
GDIDQVFEAWSGKLMRFLKAGVAENGVALGNGVGVDAEGEAEYSDVSDYDEEEEEEETVV
ESGVVDLEDIAGKAPSRGTVTVAKTKTNGIVNGKRDMVTPVIRASLEKQGYKIIGSHSGV
KICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWK
MDDPLEIVKTAIDLHSKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINTLV
DELHCRRISTFLVTNAQFPEKIRMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFID
SLKALKEKQQRTVYRLTLVKGWNTEEIEAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTM
ENVPWHADVKAFSEALALRSNGEYEVACEHVHSCCVLLAKTKKFKINGQWFTWIDYEKFH
DLVASGKPFDSNDYMAATPSWAVYGAVEGGFDPYQSRYRKERHHRSNQ
>A0A662QQ30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nanohaloarchaeota archaeon|TrEMBL
MSVKMVLKLSETAKKKLLHAQYGLFGHSAVQICSWTKKSLIDKGVCYKEKFYGVDSHKCM
QFTPLSLWCTNNCVFCWRPASYLNNFDEKKMVDNPENIVENLIVERKKLMRGFGGNDKVD
KEKLNDAYVPNHFAISLSGEPTLYPKLCRLIEYLKNEKKARTVFLVTNGQVPDALEKLDR
DKCLPTQLYISVSAPNEEKYIEISRPKQKGAWRLFGKSLDVMNGLKCRTVLRMTMINGLN
TGEEYFEDYAKLIKRANPDFIEVKSYMHIGESQKQLGKENQCDFGQVREIGKKLCEYVDF
DYCDDAANSRICLLKNREGRYGKIIEV
>A0A4P5YKT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilaceae archaeon|TrEMBL
MSCSGETVENEDRLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVAEPKEILTKLMEERKKLIM
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSFLKINKPKYNDSWQRWNKTLEMLKHLDTRTVL
RITLIRNYNDQKEMIPAFASMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVRKFS
EEIAKQSQAFSVMDESLVSRIVILQNDQRVIDRLISTCTNTN
>A0A3N6LQY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrarchaeobius chitinivorans|TrEMBL
MSNSADSVDASAGTETDADGDDSDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCY
KNIYYGIESHRCIQMTPVVKCNERCVFCWRDHRGHAYEMDEVEWDDPEAVVDASISLQKK
LLSGFGGNEEVPRDVFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGT
RPDVLRECDPTQLYVSVDAPERHTFDQVVKPVEDGAWDRLLETMDVLAEKDETRTVLRTT
LVEGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSSMPDHEDVVEFADGIRT
HMPEFTELKDVPASRVALLSKTRDTWVPKLKKDSEFWDADPVAGD
>A0A7G9YTU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-1 ERB6|TrEMBL
MEPEAMLNYNEAEETKTRKTLEKQGYHFVGTHKHSAVKTCLWLWKSIRGEGNCYKGKFYG
ISAHRCVQMTPSIFCNQRCVHCWRPLEAFNININTGAEAEGVVWDSPEEIAEGCLKEQNR
LISGFKGSPKTDRDVFAEAESPKHVAISLIGEPTLYPYLKELIQEFHSYGMTTFVVTNGT
NPDVVREIEPTQLYLSLNAPDETIYKGVAHADYWSRINESLDELRMKKGKTRTVIRITCM
QGRNMVNPAGYAELLKIANPDFIEVKAYMHLGYSRKRLSREAMPAHRQVKEFASEITERL
AAAASDAKAKAKANANYNYRIVDESEISRVVLISNVSLEKHSLFSKQR
>A0A7C1GC79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum adornatum|TrEMBL
MESTQRMEVARYLRAGYKLVGNHSAVAICRWTRSAIRGERLCYKSWYGIQSHRCLQMTPV
LNFCDFACKFCWRMHLPGRFKIPNGWRWDEPEDIINGSIIAQRLLLIGFKGNPKVTKERF
LEAMFPRHFTISLDGEPLLYPKLPDLIKRINERNFTTFLVTNGSIPMRLKEMLKKDAHPT
NLYLSLYGPNKEVFQATADPKIPNAWENVLTSLELLDQFKKSRTVIRLTMVRDLNMVEPE
GYASLIKKANPMFVELKGYTWVGESQKRLPITAMPTLDELEKFAEKIQEITGYKIKVKDD
KSRVVMLVRDKDAWETNLKMVEEWKQKVSKLDENWKSKVEDFTMEEHGYKLLYY
>A0A0V0YE57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LYSNKLCHVELDNTENIWKAYYKMLERILHVFFPSDMITFNLCESVLIIVGISTALIVIL
LYIIMKKKEKEEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLE
NEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRS
TFNKVAINLSKHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSV
HDNKRVSVWHDENENSSDAEDAENSANNVGDIEDICERYELMHFTNVTNDSDKIKEMLTP
TLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACAN
KCVFCWRHHSNPVGTEWKWKTDSAEKILFDSLEGHKKMVYLELKMLDLRNRQRFVIAHCL
WLESQSCTPISMN
>A0A7M4EJV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Crocodylus porosus|TrEMBL
MDASVDIWSYLYTHLMSLWLHRFYIYSCAAFGISIWICIQFFAGKIKKQGGKASRKPASL
EVTDDVLVNGYATPKAKEVYVAGVKIFYGSQTGTAKGFAAVLAEAMIALTLPAEIINMRE
YDPDDCLAEETISKNVCVFLVATYTEGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSVYIDHYNTVGKNIDKWLWMLGANRVMTRAEGDCNVAKSKHGSIEADFAAWRAR
FLLRLQALCKGEKKSCSGNCKKGKCKSKVKQSREGSDHEQRVSEQENSEVEELFETTSEE
ESGAEEDGDVSSVIDVEDLGKLMGHMKKAKKEHELDERAGRMDRSFRTIGKKEESEQREM
ITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHQCMEATPSLA
CANKCIFCWRHHTNPVGTEWRWKLDQPEMILQEAIENHQSLIKQFRGVPGVKADRFEEAM
VAKHCALSLVGEPIMYPEINRFLKLLHGHRISSFLVTNAQFPEEIRNLEPVTQLYVSVDA
STKDSLKKIDRPLFKDFWQRFLDSLKALAKKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKFKINGEWYTWIDYNRFQELVQNYDESGGSKTFTAADYMARTPCWAVFGSRER
GFDPLDTRYQRKNKKDISGC
>A0A1Q7FBL9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrososphaera sp. 13_1_40CM_48_12|TrEMBL
MSCSDEHVSHSTDNLIQITPQLKARLQKAKYGVYNHSAVELCHWTRKSFANEGNCYKHKF
YGISTHQCMEMTPAAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDVIVEQLMAERKKLI
NGYYGNTKNDKRKLDESLLPAHYAISLSGEPTMYPKLPKLIKYLKSLKATKSIFLVTNGQ
EPDMLRRLTAEDALPTQIYLSTNASNKKMFHQINRPLHKDAWERWWESLRFLATVNTRTV
LRMTLIRGYNDSKNFVGEFGEMMAKGNPHFIELKSYMHIGMSNRRLEQDHMLEMQEVRDF
AVQLCEKMSSFKMMDESEVSRIVVLQNQARYTDRWIKEYIMPAS
>A5AHU2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vitis vinifera|TrEMBL
MAADVACCGTKFFIYVVIIVGLVGFAGLMAGLTLGLMSLGLVDLEVLIKSGRPQDRIHAA
KIFPVVKNQHLLLCTLLIGNSLAMESLPIFLDKLVPPWAAILISVTLILMFGEILPQALC
TRYGMTVGATMAPFVRVLLLLFYPIAYPISKVLDWMLGKGHAALLRRAELKTFVDFHGNE
AGKGGDLTHDETTIIAGALELTEKTAKDAMTPISKAFSLDLDGTLTLWVYKFLINLSISI
MFPCHSYVFILFSLRETLNAIMTIGHSRVPVYAGKPTNIIGLILVKNLLMVDPDDAVPLR
KMVIRKIPRVSENMPLYDILNEFQKGHSHIAVVFKDLNETKEAQNKTKDGALQVSMKREQ
DEVGATAVTHNLGVKQELHDAGTAVAKNDADQQQKKNPAVPVFKKRHRGCSFCILDVENA
PLPEFPPNEVAVGVITMEDVIEELLQEEILDETDEYVNIHNRIKVNMHASSQEKDPNSNX
PQPSTKVSSIAGMLTPTLPASTGLNPAQNSPISPCLEPPDHWSLWEMALARFGRQAKRPY
GVCVKMTAVAVLGMCFIFVWSMFSASPSAVTSQRSSFGDINEPVPGSTGVGSSRTGLKKN
EPEKTELSGGSNKVKFESDLEEKDEKKLDGSVTLAANGNNSTNIDKKEEANEGKEGIDKQ
NHGSEGSENKESEKEKEEGEVGGDDKEEAVDREGEANEDVDADGDWAVTVEEEPVGKVEE
ESGGSKSTGKKKKRNGPLFDLKAQYTWKLCSTRSKHNYIPCIDNESGTGRLQSYRHRERS
CPRTPPMCLIPLPAKGYSSPVPWPESKLKVCEELRLSLFGSSVSDEAFVISFYILQDVSF
GAFLLDKEVLTLSLGLKDDLVDLAQVALERGFPAVVSPFGTRRLPFPSGVFDAIHCGGCN
IAWHSNGGKLLLEMNRILRPGGYFILSSKHDNIEDEEEMTSLTASICWNVLAHKTDEISE
VGVKIYQKPESNDIYELRRKKNPPICKEDEKPDAAWYVPMKTCLHTIPAAIEERGTEWPE
EWPKRLDTFPDWLENRDKLIADSEHWKAIVSKSYLTGMGIDWSNVHNILDMKSIYGGFAA
ALSDQKVWVMNVVPVHAPDTLPIIYERGLVGIYHDWCESFGTYPRSYDLLHADHMFSRLK
NRCKQPVAIVVEMDRILRPGGWAIIRDKVEILDPLEGILRSMHWEIRMTFAQDKEGTSEI
LARRLLRLLTSCDLSFDLVHPKDYEPEDLSKETLVLIVASTWEDGNPPPDAGFFSNWLAE
SADDFRVGSMLLSRCKFAVFGVGSRSYGAAFNAVARGFSKRMRKLGGLQVLPVEEGDVDA
GDLDEVFDVWSRKLISVLKGGSVENGVFDGSMAVVESDAETIDGSEEDYDDDDDADRENG
AEGSIVDLEDIAGKGPSRKTKTMTTSSGTINGEKEMVTPVIRASLEKQGYKIIGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRAGRWKMDDPLEIVNSAIDLHTKMIRQMKGVPGV
KAERLSEGLSPRHCALSLVGEPIMYPEINSLIEELHRRRISTFLVTNAQFPEKIKELKPV
TQLYVSVDAATKDSLKAIDRPLFGDFWERFVDSLKALREKQQRTVYRLTLVKGWNTEEID
AYFNLFSIGKPDFVEIKGVTYCGSSATSKLTMENVPWHADVKAFSEALALKSKGEYEVAC
EHVHSCCVLLAKTDKFKVNNQWFTWIDYEKFHDLVASGRPFNSKDYMAATPSWAVYGAEE
GGFDPGQSRYRKERHHRPKTTD
>A0A671WIW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sparus aurata|TrEMBL
LKSMLNDSTHIDTTESYFMSIWHNRLYLYSAAALVFGIWFSLKVALKKVNSLLAHIITSL
AHSSVKNNDRDTVVHLSGVKIFYGSQTGTAKGFAQELSEEVKTLGIPAEVIDMKDYDPDD
QLADECSNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLG
NSVYVGHYNTVGKNVDKWLWMLSGMRVMTRGEGDCNVVKSRNGSVQADFLAWKVKFLNRL
QALAKGEKKSCSGNCKTGGSCKSKRRDTQEEEEEEEEKAALKNNGSEELIESSSDDEESG
PQDEEKSASVVDVEDLGNIMNSVKKAKSKDESRGDGQMVKLSKLNGMGKIEDEGERREMI
TPALRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDPKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVG
EPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFVEVKGVT
YCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEW
WTWIDYERFQELVQTHEESGGRQSFSALDYTAKTPSWALFGANEQGFDPADTRFQRRNKT
KDISGC
>K2QDM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium formicicum (strain DSM 3637 / PP1)|TrEMBL
MPLTDQAIEALEKKGYRFVGSKRHAAAKVCHWTKKSIMDDGVCYKEKFYGIESHRCLQMS
PSIAFCHHKCLFCWRDISITSTTWEEEFDDPGEIIDECIKAQRKLLVGFFGNPNANSQKI
AEAQDPTNAAISLAGEPLLYPSINQLLEEYKKRKFTTFLVSNGLSPDKLGSLDPEPTQLY
LSLDAPNIETYKKLCDPQIKDGWEKLNHSLDLLSSFNCRTVIRMTSVAGYNMTHPEEYAR
IIEKSDPDFVEIKAYMYVGSSRDRLKFENMPRSNDLKNFAQEIASLCGRKIVDESPESRV
VLLA
>A0A830CCE6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phtheirospermum japonicum|TrEMBL
MSPSLPSTRLTLLTLLSATATLYFLYKSRHRHRRLLTRLRQSLAKPDLRSPNPASPKRGK
LFFISQTGTAKTLAQRLQALLTLNDLPFDLVDPKDYEPEDLCKETLVLIVASTWENGGAP
DNGAFLVNWLSESADDFRVGALVLKECKFAVFGVGSGSYGETYNAVARGVSAKLRKLGAS
EVVELGEGDVDEGDLDGVFDGWSKKIVAVLKGNLGENGGNFDNCEVGSESEDEYVSSEED
DDDEVDSEGESGIVDLEDIAGKGPSRRSTVEAKANGKSNGHVSNGEKEMVTPVIRANLEK
QGYKVIGSHSGVKICRWTKCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLVIVD
TAIDLHTKMIKQMKGVPGVKAELLSEGLSPRHCALSLVGEPIMYPEINSLVDELHRRRIS
TFLVTNAQFPEKIEALRPITQLYVSVDAGTKDSLKAIDRPLFSDFWERFVDSLKALKEKQ
QRTVYRLTLVKGWNTEDVDAYSSLFDVGNPDFIEIKGVTYCGSTATSKLTMENVPWHADV
KEFSEALARKSNGAYEVSAGEPFSSKDYMAPTPSWAVYGAEEGGFDPQQSRFRKERRHHK
SKA
>A0A7J9P9L4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVKKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKDLFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A1L0C281|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] intermedia|TrEMBL
MDLKSAIFAVCCALYYFSGGRFSLVVAASTWYVLSTRGKESLTRQKPLPIKEVDFTHAYM
PEPTTVFPKQRKTVKRARSPKVFRGAKPAVKDQGTVLTSTPIRLMDSQVYIFYTTLTGTS
QRVAAALHDKLANLEGIAHEPKLLSLDDDVDDLEEYFLKTPKNSTQNIYLLVLPSYETDS
PIDYFIEHLTDTFQDFRVDKYPLRSLAGFAVLGLGDSESWNGSKFCYQALLADKWLGKLG
ARRLFPVGQVCVKHEGEPKTQEWINGFASLLADDEPFYIDDNDAADDSDAEEDEIDPATD
VVDVEDMGAIIKASGGSFTVEPKQMVAQDSPTFRSLTKQGYTIVGSHSGVKICRWTKSAM
RGRGSCYKYAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWEVDPPEKVLA
GALEGHYKKIKQMRGVPGIQLDRFQEAFQVRHCALSLVGEPIFYPHINEFVGMLHERHIS
SFLVCNAQHPDHLARLAKVTQLYVSIDAPTKKDLKKVDRPLNADFWERLMSCLDILRTTQ
AHQRTVFRLTLVKGFNMDDIESYADMVERAQPSQIEVKGATFCGSSNANGNPLTMQNIPF
YEECRVFVEKLTAELKSRGLSYELAAEHAHSCCILIAHTKFKINDVWHTHIDYPRFFELL
ESGEEFCDLDYVKETPAWAVWGSAEAGFNPEDTKYDRKAEKAKKREAREALAAKVADL
>A0A7J9RYA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLDGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCLRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLDMGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>V4KCW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eutrema salsugineum|TrEMBL
SRGKIFFISETGTSKVLAQRLHELCASNDIAFDLVDPRDYEPEDLPKENLVLFIASTWDG
GKPPQNGEFLVNWLSESAEDFRVGSLLLSECKFAVFGVGSRAYGESYNAVAKELSSRMVG
LGGVEMIPVGEGDVDDGELDRAFQDWCAGVIRFLKVGSAHEKDGVAQNVAAESDHEYIDS
TDDEEEDNSGDIVDLEDIAGKAPSRRNGLVKVPKGDGKKEMVTPVIRASLTKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKS
WQWKMDDPKEIVKGALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEI
NALVDELHGRRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWE
RFIDSLKALDEKQQRTVYRLTLVKGWNTEELDAYFNLFSIGKPDFIEIKGVTYCGSSATS
KLTMENVPWHADVKSFSEALSLKSNGEYEVACEHAHSCCVLLGRTEKFKVNGKWFTWIDY
EKFHDLVASGEPFTSTDYMAPTPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVLA
>A0A8J8EU47|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. GR5|TrEMBL
MAITFKSNPNMPGEIARLFKKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPGPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTAPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKITRTLELMNGLPTRTVIRLTLVKDE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A0U2V5P3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter millerae|TrEMBL
MSFNTSQQEKLEKSGYRFVGTHGHAAVKTCHWTRQSIVDKGVCYKEKFYGIESHRCLQMS
PAVPNCQQECEFCWRDLTYTQTEWEDDEYDDPKTIVDGAIEAQNNLLCGYYGNDKANSKK
LEEIKKPTNAAISLAGEPTLYPKIDELIGEFNKRDFTTFVVSNGQCVDRLRNLENDPYQL
YLSLDAPTSKIYDAVCRPRISNAWDNLNESLETLSSFNSRTCIRNTCVKGRNMVNPEKYA
QLIDKANPDFVEVKAYMCVGSSRQRLTLDNMPTFDEVKDFAQKIGDNCGREISNESEVSR
VVLLE
>A0A832PFW6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp|TrEMBL
MFISKFEKLKRLERMGYRFVGEHAHTAVKTCLWTKKSILDEGTCYKQKFYGIKSHRCLQM
SPSIFFCQQKCLFCWRDLKYTRTEWDGDYDEPADIIDDCINAQRNLLCGFFGNEKANKKK
LLEAQEPNNAAISLAGEPLLYPMINELIKEFHKRKFTTFLVTNGINYKALENLSEEPTQL
YISLDAPSEKIHKKLCRPQTENAWEHLNRSLELLPSFNCRKVLRITAVNGKNMTNPRGYA
TLIKKAQPDFVEVKAYMYLGYSRKRLEMENMPLFFEVYEFADKIAKLTNMNIIDKSKESR
VVLLG
>A0A852L2N7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Urocolius indicus|TrEMBL
LDVSMDTWNFFYTCLVSFWLHRLYIYSAVAVGISIWIIMQFTTIKLKKKMTEHGNLAASE
GVKDKLVNGCATLQAQEVYVAGVKIFYGSQTGTAKRFAKDLADAVVSLNLPVEAVSMGDY
DPDDCLSEETSSRNVCVFLVATYTEGQPPESAAWFCKWLEEAVSDFRFGKAYLRGLRYAV
FGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKF
LSRLQALCRGEKKPCSGKCKKEKCKSLGKQSKDSSDHEHGASEDKKTEAEELFETSSEEE
ADAEGHGGRNSVVDVEDLGSIMSHMKKAKRERELEEGDGGMSLTGENGGRKEEGEKREMI
TPALREALTKQGYRLIGGHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEALT
VKHCALSLVGEPIMYPDINRFVKLLHQHNISSFLVTNAQFPDEIRNLEPVTQLYVSVDAS
TKESLKRIDRPLFKDFWQRFLDSLKALSEK
>A0A851RZM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Certhia familiaris|TrEMBL
LDVSMDTWSYFHTCLVSMWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPGTEYKLG
NGCASPQAQEAHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDCDPEDGLA
EETSSRNICVFLVATYTDGQPPESAAWFCKWLEEAASDFRVGKGFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQVL
CKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELSETSSEEEAGSTESV
IDVEDLGNIMGHMKKAKVLLLEGYGMVSHSGYHLVYFVCQFLQAKLNCLMVYVLFSGYKL
IGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPEVILQEALEKHQNMIRQFRGVAGVKAARLEEALAVKHCALSLVGEPIMY
PHINRFVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKD
FWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGES
SASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKVSLPG
>A0A5E4FB68|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus dulcis|TrEMBL
MSLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSSSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNGLAFDLVDPNHYEPEDLPKETLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGASEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNGVGAECEAESFDGSDEDEEEEDDVESEV
VDLEDIAGKGPSRRRTVTVTKTNGTVNGQKEMVTPVIRASLVKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACSNKCVFCWRHHTNPVGKSWQWKMDDPL
EIVNSAIDLHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHR
RRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSL
KEKQQRTVYRLTLVKGWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPW
HADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSS
GRPFDSKDYMAATPSWAVYGAEEGGFDPYQSRYKKERHHRSNQ
>A0A3R8AJG7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii CAST|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVPE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
IQRSTAASHLIPPRSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQILLLSRATEQKSGKTKELSGKAGRKAGAAECRAGSHELPGAETIDDRH
RMHAIDDERATGEGSDIDTKGGDRELQSAVFPEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGREARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSANVSKECHTGAKPQGSSAAASAVGEDSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKERGKAKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A2N5W4Y8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia coronata f. sp. avenae|TrEMBL
MLIGLLDSITSRLSAISPSTANTTATAHEEPRLSTQILYSSLSSTTKKLAQQLTAEITTS
SPHLNASLESLDHLDLDQLIVQTPVHATHQLAVFLLPSYNVESPVDSVLAQFRDALYDFR
VANNSLAGLGYAVVGIGHSDYRHEFCKQALELDHILDGLGARRLIPIRKIDVSVDPERDI
KDYCHYVLQTTFTPSLKSFAELSSIKSQPVKYSSENEEEQEEEEEVDNSDDEFVDYSSPT
KPLSKAEIARQKSQKLLKRKKGNQDPKSGTLDIEDLGAGVPQIADLGEDPSSNSKEEGLE
AQMIKKDMISPMTRKSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQC
MEATPSLACANKCTFCWRSHTNPVGTSWRWKTDDAEFVVEESLKEHDRLIKQLAGMPGVR
ADRFSEARTPRHAALSLVGEPVMFPHIKKYISLLTEKHISTFLVTNAQFPDSLLDLPPVT
QLYLSIDAGTKESLKSIDRPLHRDFWERFLASIDIVRTKKVRTVFRLTLVKGENSDEIKE
YAELIRRGQPDFIEVKGVTYCGYPGSSNLTIKNSPWHNEVIKFVEDLCEEINDPRYRTST
DSNADEAPVAEYGLAAEHAHSCCVLAAHQKYYFDDQWHTWIDYDKFFELVESGASQFDGL
QYCAPTPEFALFGAPQAGFSPEDQRWFRKKTLAKIALDAAGPAVVADPE
>A0A812DZ92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sepia pharaonis|TrEMBL
MPPFLSCSCHLFSPALATFSLLLLPPFLSCSCHLFSPALATFSLLLLPPFLLPPFLSPPF
LSCSCHLFSPALATFSYHLSSHLPSMFPLSSTFLPSLPTNFSLHNFLLFFSSLCSSFLLH
TSFPCFFFIYLFLFTLIFLFNLLPTVFTPSFLCFLYLLPVSPSYPLFLPLYHPMFLLHVL
FSFLLLYSLTFLPHTLFFFLPFPLPPKPFHHNTFFLLLYLTYQIPSHLIFPHNTEVTNLK
DYDPEDHIKHFRDPKRVYVIIISTFVEGSPPEDAAWFYKWLKESAVDFRVQKNFLEGMKY
AVFGLGSSVYKGNYCVVAKNIDQWLHQLSASKILPIGLGDENVAESVHGDLMSDFNAWRK
KFWKRVAPILKGEELVTATGKCCKENCDNKNCQKEKTNGHLLTEETFEETSSEEDNEEVE
EDIFSSNGLVDLEDLGKVMKNVKITKTKPVTNGYSVLTKKQKEKLDEPKAMITPVFRKSL
EKQGYNLIGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWLMDNAETILKGALEGHCKMIKQFRGVPGVIPEKFNEGMSPKHCALSL
VGEPIMYPEINKFVNLLHNKEISTFLVTNAQFPDAIRNLVPVTQLYVSVDASDKESLKKI
DRPLFRDFWQRFLSSLEALATKRQRTVYRLTLVKGWNTDEIEAYAKLVNYGKPDFIEVKG
VTYCGESKASTLTMKNVPWHEEVAGFVEELADHLPDYEIACEHEHSNCLLIANKKFKKNG
DWYTWINYDRFHELVKEHCVNTNGSRTFSAEDYMARTPDWAVYGAKEKGFNPTETRFHRK
KKKDISGC
>A0A8C6V8Q3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Naja naja|TrEMBL
MGLQANLTNGLGPDTPADTWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQ
NKNCLAELNLSKITVAEKEQRDPSFEKVHVAGVKVFYGSQTGTAKRFALVLTEAVASINL
PAEIIDMQDYDPDDSLIDEISSQNICVFLVATYTDGKPTENAAWFCKWLEEAANDFRVGK
AYLKGLRYAVFGLGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHGSIE
ADFEAWKAKLLIRLQALAKGEQKACSGRCKKGQCRSKSKVSQEAKEQETSEHVENEEEDF
FETTSEEESDTENGRGADQVVDVEDLGKVMDQMKKSQKEHQTNGVIPIGVGTQHGRGEDE
RREMITPALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRDDRF
REGMEAKHCALSLVGEPIMYPQINQFLKLLHHHNISSFLVTNAQFPDEIRNLQPVTQLYV
SVDASTKDSLKKIDRPLFKDFWQRFLDSLQALAEKRQRTVYRLTLVKAWNVEELKAYSDL
VSLGKPDFIEIKGVTYCGESSASNLTMANVPWHEEVTHFVQDLADLLPDYEIASEHEHSN
CLLIAHKKFKIEGKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAKER
GFDPVDTRFQRKNKIKDISGC
>A0A3G3IHI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomethylophilus alvus|TrEMBL
MDEEYRQTLIRQHYRIYRDHAAVKLCGWMKQSLLHQRTCYKQDFYGIQTHRCLQMTPALN
ECTHLCPFCWRVEGKDFEVKEWAEPKEMLDALIDYQRLLISGFKGDERCDPVMFQEAMNP
TQVACSLAGEPTIYPYLSEFFKECHSRGMTTFLVTNGTMPERIEALDTLPRQIYVTVAAP
DKATYAKACRPKIKDGWERLMRTLELFPSLETRTVVRHTLVQGVNLMDPESYARLDRVAD
PDLIEPKGYVFVGGSRQRLTVDGMPAFETIKDFSKRIADILGMDVLREKADSRVVLLGHE
GMELDVRKAWEKGLPPSPRMDRLTADMCQ
>A0A1H8ZJJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema salaciae|TrEMBL
MSDSANPGRDGASDGRDTGDGDAGGPAQVSSPDYHSENHTAAQTCGWTANAMRGEGKCYK
NIFYGIESHRCIQMTPVVRCNERCVFCWRDHKGHSYEMDDVEWDDPEAVVDASIDLQKKL
LSGFGGNEAVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTR
PDVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMDVLAAKDETRTVLRTTL
VKGENMRNPDWYAGFYQQADPDYVELKAYMHVGHSQGRLDRSAMPEHEEVVAFAEDVGEY
MPGFDEVKGVPASRVALLAKTADTWVPKLKKGSEFWDRDPVTGD
>A0A2S6CCP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cercospora berteroae|TrEMBL
MMERLSDLPREVLLLYHAHRVEVLLSAGILLAAIRLLAHWRSKQAKALLTPPLGSPVQEK
PLQLVDEKEAVSGSIPQTLPAEPLKPKGPKRVKGVRTAKRKDSPVRAIDQIQPYVFYYSL
GGSTRAYAEKLASTIETNEKVLTPLVHDLTEIDYDDYFISAPKQARSATAAFYYVLLPSY
NIDTELSNFLSHLEETHHDFRIDDQSLSGLAGYSVFGFGDRLEWPTEGEGYCSQAVEVDR
WMAKLTGKKRAYPLGTGDVKGDDADMRLEEWRRGVYNIIEDLGRGQGLGVGVPGSGDPAE
SGDEASENEDEETLFPAQTRTTKRTTTDDLEDIKAPIPVDFTTTSTKKASQPAVPKAMVP
KESPTYSSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMEATPSLA
CANKCVFCWRHGTNPVGTSWRWTVDPPDEIFQGMTAGHYQKIKQLRGVPGVRAERFAEGM
QIRHCALSLVGEPIFYPHINELLGMLHASHISSFLVCNAQHPEQLAALGPVTQLYVSIDA
SNKDALRKIDRPLHRDYWERFTQCMDILREKRHTHRTVFRLTLVKGFNIDDEAQGYADLV
ERALPAFVEVKGVTYCGTSTSKGAGLSMQNVPFYEEVQAFVLALERELKKRGLDYGIGAE
HAHSCCILLADKTRFWRPLEGRNERNVRTKYEGAGRYHTTIDYPAFFRCVESGEKFGPED
YVSETPTAEWALWGNGGFDPRDERVDRKGRPKEIDEVKRVVEI
>A0A2U4A8Q7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tursiops truncatus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLGLPVALINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKDVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEEEPFGSTSEEESGTE
DHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALREA
LTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCALS
LVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKIG
REWWTWIDYSRFQELVQEYEDTGGSRTFSAKDYMARTPHWALFGASERGFDPKDTRYQRK
NKSKDISGC
>A0A8C9TVL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
MDNHWLRRLQIILGLIFFCFQGFARNLAEDLHALDLIAEVIDLKDYDPEDSLSDECTSKA
ICVFLLATYTDGLPTENAEWFCKWLEEASTDFRYGQTYLKGMRYAVFGLGNSVYTGHYNT
VSKNVDKWLWMLSAARILTRGEGDANVVKSRHGSLEADFGSWKARLLKRLEALVRGEKKA
CSGKCKKGTCKSKGKGKVLEQSEHHSSEQLMETSSDAESATGEEADHRSVVDMEDLGNVM
NLMRKAKVEDSRQELKRRKSEEEEHREMITPALREALTKQGYKLIGSHSGVKLCRWTKSM
LRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEIILQ
EALQNHQNMIKQFRGVPGVRPERFEEGLTAKHCALSLVGEPIMYPEINAFIRLLHRQRIS
SFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALGEKQ
QRTVYRLTLVKAWNVDELKAYADLISLGQPDFIEVKGVTYCGESSASNLTMANVPWHEEV
VHFVRQLADLLPDYDIASEHEHSNCLLIAHRKFNVEGQWWTWIDYERFQEFAQLYEESGG
QRTFSAEDYMARTPDWALFGAKERGFDPADTRFQRKNKTKDISGC
>A0A2V1AY86|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] haemuloni|TrEMBL
MASGTPILALCSLIYWLSGGRTTVLAAAWFAVFVHKQKKHDSKSSPITEPVKSSRIMEVD
FTNAFTPETKTTFPKTVPLKKKTRKTRTAKVFKAKPGKSVGGGGGAVSHLTASSVHLEKC
PVYIFYTTLTGSSLRVAKALHEKIAGIDGVEVPPRLLSLDDDVDDLEEYFLRTPKSENPP
VYLLVLPSYETDSPIDYFLEHLTETYQDFRVDKYPLRTLAGFAVLGLGDSESWGGSQFCY
QAKSADKWLGKLGARRLFPVGEVCMKHEGEPKTQDWINGFSELLVDEQPFLLEDDPAAFD
SDAEEAEAEAEDEKDVVDVEDMGAIIRASKNKDSAVMEPKQMVAEDSPTYKSLTKQGYTI
VGSHSGVKICRWTKSAMRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPV
AKSNWRWEVDPPEKVLFGALEGHYKKIKQMRGVPGIQIDRFQEAFRVRHCALSLVGEPIF
YPHINEFVGMLHERHISSFLVCNAQHPEPLANLAKVTQLYVSIDAPTKTDLKKVDRPLNS
DFWERLMSCLDIVRTIQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGATFC
GSSTGNGNPLTMQNIPFLEECRDFCRQITAELQRRGLDYELAAEHSHSCCILIAHTKFKI
NNVWHTHIDYPKFFELLESGQEFCDLDYICETPEWAVWGAEEGGFNPKDTRYDRKAEKLK
KKQARDDAAAKALQVQKAESIKATTNEFSEHTRELFVS
>A0A8C5LI80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptobrachium leishanense|TrEMBL
MKWKMMGMQAFLCASLLHCVCADHVDADTSGTWDFIYTHLMLLWINRFCIYSCAAVGIAL
WICSHFISRKSKEPKYSSQNGSPVLQTEKLEKENHCSPKEIFVSGVKIFYGSQTGTAKGF
AHLLAEDITGLGLPTDIINLMEYDPDDHLAEETTSKNICVFLVATYTDGQPPKSAEWFCK
WLEEASNDFRYGKTFLKGMQYAVFGLGNSVYSNHYNTVGKNIDKWLWMLSASRIVTRAEG
DCNVVKSKHGSIEADFSAWKFKFLERLQALMEGETKACTGKRKKGTCKSMKTSSTEALAE
EENRADNSENEQTEEELYETTSESEPEEAGEGGSSGLIDVEDLGKAMRNMKKSKNVGSDP
GSPGKPVQSEEPREMITPALQKALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFY
GIESHRCVETTPSLACANKCVFCWRHHTNPVGTEWKWKMDQPEMILEEAIENHQNMIKQF
RGVPGVKADRFEEGMAVKHCALSLVGEPIMYPEISRFIRLLHEREISSFLVTNAQFPEEI
RCLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAW
NVDELRAYADLVTIGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLLPD
YEMACEHEHSNCILIAHKKEEWWGSRIALVLPGGFGH
>A0A497J8W3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Hydrothermarchaeota archaeon|TrEMBL
MIEMNEEVRKLLEKQGYRIVGNHSAVKLCHWLRERLLRKRPCYKSKFYGIASHRCLQMSP
SVAWCQHRCLFCWRPVEHTLGEEINVSLDEPSFIVEKSIEAQRSLLSGYWGEKRVDRKDM
EEAWNPKHAAISLAGEPTTYPYIDELIEEYHKHGFTTFLVTNGMHPERLEKVKPYQLYLS
LIGYDEESYKRICRPTIKDGWQRLMESLEIFSGKKLRKVIRLTLVKGYNLEHAEKFAKLI
ELASPTFIEAKGYVHVGFSRQRLRRENMPTFDEVKEFAIALEKATGYKIKDYVEESKVVQ
LAK
>A0A2H9PYH2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon CG_4_10_14_0_2_um_filter_31_10|TrEMBL
MKLATPTEIAENLKHKHYGLSKHGAVQICLWTKKALRNEGVCYKEKFYDAHCHRCMEMTP
LAVWCNQNCIFCWRPSEWLNLNDLKKELEKPEEMVEKLIEKRKKLLSGFGGSVKKYKTER
LFKESLIPDHFAISLSGEPTLYKKLPGLIKLLKEKYKARTVFLVTNGSQPEMLLKLQKER
ALPIQLYISFESPNENDFLKTNKPRSKNAWKTLMRTFSILPKLDVRKVIRITLMKNINDS
EEKIKQFSMIINESFADFVELKSYMHVGSSRERLKKENMLEHKEIKEISKKFLKYLKNFR
YEDEQKESRIVLLKNKKSPYKTKFD
>A0A843KV01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp|TrEMBL
MHSEACKALRRQGYQFVSPASSAAVKPCMWNKRALRGGEMCYKAQFYGIESHRCVQMTPT
LRCNQHCLFCWRSFEHEVVEEEECPPPAIIENLRRLQKKALSGYKVSPYVAPERFAEALR
PTMVAISLSGEPTCYSRLPELIDGLNTGGYTTFLVSNGTRPDVLSRCRPYQVYVSLDAPD
RETYLGLCRPREDYWDRVQESLAGLAGRRSAIRTTVVHGYNDFAPERYAALYQDSGARFV
EVKGYMYLGYSRNRLQRDQMPEHSDVRAFAEKIAQHCDYTIRDESPASRVVCLERNV
>M1XKB1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronomonas moolapensis (strain DSM 18674 / CECT 7526 / JCM 14361 / 8.8.11)|TrEMBL
MPKQVDDPDYHSENHTAAQTCGWTANALRGEGRCYKNHFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELGDVEWDDPDAVAEASIELQRTLLSGFGGNDAVPEEAFEEAMEPRHV
AISLDGEPTLYPHLPELIEAFHDRGITTFLVSNGTRPEVLERCDPTQLYVSVDAADRKTF
GEVVNALEDDAWDRLVETLDVLADKDDTRTVLRTTLLSGHNTHRPEWYAAMYDRADADFV
ELKAYMHVGNSRDRLDRDVMPDHEAVLAFAEAVGEYLPTHPVVRDVEASRVALLAREPDT
MVPELKGGSDFWREEPYADS
>A0A3Q1J330|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anabas testudineus|TrEMBL
MSIWHNRLYLYTAAALFFGIWFALKISLKKKNSKDVNSSVNKTEKSSERSDKQKVVHVSG
VKIFYGSQTGTAKAFANELSEEVKALGIPAEVTDMKEYDPDDQLADECTRKSVCVFLVAT
YTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYFGHYNTVGKNVDKW
LWMLSGMRIMTRGEGDCNVVKSRNGSVQADFLAWKVKFLKRLQALAKGEKKKCSGNCKKG
GSCKNKRKDRKVEEEGEKAEDVQTDDQIVKLSKLNGVKNIEDEGERREMITPALREALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDPADKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLEVKHCALSLVG
EPIMYPEINAFIRLLHSHRISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKESLRKIDR
PLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAVGQPDFIEVKGVT
YCGESSASSLTMANVPWHQEVVTFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEW
WTWINYEHFQELVQAYEESGGQQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKT
KDITGC
>A0A1Y6LVL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zymoseptoria tritici ST99CH_1A5|TrEMBL
MGDSHLLQLPQELLLLWHAHRTEILISAGFLVAIVRLTLHWRSTKTKAILTPPLGSPVTE
KPIRFPEVVQEKTVPTAQPVKTNGPRRVKGVKKVKKQEQAKDERPPIDKIQPYIFYFTLG
GSTKAYAEKLAESFILPDAKDRVLPPQVHDLTDIDYDDFFISPPKYDSPGTAAFYTILIP
SYNIDTELHNFLSHLQETHHDFRIDTAPLQTLAGYSVFGFGDMQEWPTEQEGYCVQAIEV
DKWMAKLTGKKRAYPLGMGDVKDDVELRLEEWRRGVQTIVDDLSQGKGLGEGVPGSGDPI
ESEDEADEDYDDGETLITITADLEDIRAPIPVDFTTSKKSTSTTTGPPKEMVPVNSPTFN
SLTKQGYSIIGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCVF
CWRHGSNPVGTTWRWQVDPPEQIFEGILAAHYKKIKSLRGVPGVRSERFAEAMRVRHCAL
SLVGEPIFYPHINQLLAMLHAQHISSFLVCNAQHPAHLAALGPVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFCDCMDILRQKRYSHRTVFRLTLVKGFNIADEVAGYADLVQRARPGF
IEVKGVTYCGTSTSAGAGLSMANVPFWEEVQEFVLALAAELKTRGVQNDGMEYGLAAEHQ
HSCCVLLADKERFYRENAAGEGKWHTLIDYEKFFKLVEMGGEFKAEDYVSAEPTADWAGW
GRGGFDPRDVRVDRKGRPIEQKDEGRVVEI
>E5R298|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)|TrEMBL
MATIPLQAALLIWHTYRAHILAVLLLIFLVIVKLSSQCKRLESQSIAEKRNPQTTTVADV
PTQPESKKLAKSIPLRSEAKYEPKRLRGSKAPKAPKGGANTTAEAISAIRPMFFFTSLTG
STEKSARAAFERVKSKLQAAPQNIQCKVLDPELLDLSYVDFDDYFVTAPKPPASEPGTSY
LYCIILPSYDIDSIINNFLNHLDETHNDFRIDTSPLSGLTGYSVFGFGDKEGWPTMEEGF
CSQAVTADKWLAKLTGKRRAYPLGLGDVNSDGGLALQEWCDGIVSVLNDICENGGGLGEG
VPGSGDPLESDEEDAEEDYQSSRNLSRPRRLKAKGSQITDLEDIKFKPEDLLDDEPIDFT
TYSITKRPPPSSKEMVPSTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNS
FYGIKSHLCMESTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPELIFSGVKEGHYKKIK
MLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLSLLHKEHISSFLVCNAQHPD
ELAALQRVTQLYVSIDASNRESLRKIDRPLHRDFWERLQRCLGIIREKRDVHRTVYRLTL
VKGFNIEDEVEGYADLVEKGLPCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVA
LNEELARRGLSYGISAEHAHSCCVLLASNRFLVDGKWHTRINYERFFELLEREKRTGESF
TPEDYMRETEEWALWGNGGFDPNDQRVHTKGKNKGKIGVPPPSGKVVLASTA
>A0A0V0ZP17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella patagoniensis|TrEMBL
MMAYLTTHIWHSKLQYKFGQLRVGSGLYISFAYMQFMLFVKNLLMKSMVLITVRSQNLYL
KNVFQPFTVLNFKVTINTMKTRRLATLNWTILRTCGRLITTFGISTALIVMLLYILMKKK
EKDKHREEVKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIF
IVSTYVDGQCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIK
LSKHLLLLKANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVS
VWHDENENSSDAEDAENSANNVGDIEDIYFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLV
GTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVG
TEWKWKTDPAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYP
HINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDF
WQRLMNSIDILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSK
DSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDY
EKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A7K4A738|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinaceae archaeon|TrEMBL
MSQKTERSLFKIQPEDMSVKDIMKKQSYAPVGAHSAVKTCTWLKNAINDRGVCYKSKFYG
VSSHRCLQMTPTLSCNQKCIFCWRPTEIKVPDLDLEKMDKPELIVYESIKAQRKLLTGFG
GSPNAVSELYNESKTPSNVAISLSGEPTLYPYLPELIDLYKKENMSVFLVTNGTNPEMIQ
KVKPTQLYMSLDAPDFETYLNLCRPENENQWSLILESLKKLNHKRKEGVRTALRITAVKD
LNTSDPKGFSELIKIAEPDFIEIKSYMHVGFSRLRLNRSNMMEMDELKEFASKIAKHLDY
KFAGESEPSRVVLLTKDGTVNRINV
>A0A8H4BTM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saccharomyces cerevisiae|TrEMBL
MDGFRVAGALVVGALTAAYLYFGGRFSIALVIIVGYGIYCNEASGGSQDSQEKLDLNKQQ
KKPCCSDKKIADGGKKTGGCCSDKKNGGGKGGGCCSSKGGKKGGCCSSKGGKKGGCCSSK
KNIGDNENTATEVEKAVNYPVTVDFTEVFRKPTKKRSSTPKVFSKNSSSNSRVGKKLSVS
KKIGPDGLIKSALTISNETLLSSQIYVLYSSLQGAASKAAKSVYDKLKELDELTNEPKLL
NLDDLSDFDDYFINVPVENALYVLVLPSYDIDCPLDYFLQTLEENANDFRVDSFPLRKLV
GYTVLGLGDSESWPEKFCYQAKRADHWISRLGGRRIFPLGKVCMKTGGSAKIDEWTSLLA
ETLKDDEPIIYEYDENADSEEDEEEGNGSDELGDVEDIGGKGSNGKFSGADEIKQMVAKD
SPTYKNLTKQGYKVIGSHSGVKICRWTKNELRGKGSCYKKSLFNIASSRCMELTPSLACS
SKCVFCWRHGTNPVSKNWRWEVDEPEYILENALKGHYSMIKQMRGVPGVIAERFAKAFEV
RHCALSLVGEPILYPHINKFIQLLHQKGITSFLVCNAQHPEALRNIVKVTQLYVSIDAPT
KTELKKVDRPLYKDFWERMVECLEILKTVQNHQRTVFRLTLVKGFNMGDVSAYADLVQRG
LPGFIEVKGATFSGSSDGNGNPLTMQNIPFYEECVKFVKAFTTELQRRGLHYDLAAEHAH
SNCLLIADTKFKINGEWHTHIDFDKFFVLLNSGKDFTYMDYLEKTPEWALFGNGGFAPGN
TRVYRKDKKKQNKENQETTTRETPLPPIPA
>A0A165NAM7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. K1|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDNAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDSLVEY
>A0A061S8Y2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tetraselmis sp. GSL018|TrEMBL
ASIWLDVLAGLHSYILPHLTVIVSTTAVGLFSLSFGRLLLFVRRLDNKATAAQENGKGEN
GLLVLVGTQKGTSLHMARKLVARAKVAGFSTRLVSLKNYEVENLAAEQTAVVIVSTYAEG
SPPDEASWFCRWLSESATDFRVGLALLQRLRFAVFGCGNKVYGDKFNTVARAADENLAAL
GGRRLVPVGLGDEDTNDMEAQFDRWSDDLLVALRGEGAAPAPLPKPSERSVHDGSGSEEE
EEEEVAGESQADSTVTDIEDLAAGTVSSGGADGRKPKEMLTPMLRATLSKQGYKLIGSHS
GVKMCRWTKSMLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKEWK
WAMDPPDMIVRRAVESHVKMVKEFRGVPGVKPARLEEGFKPAHCALSLVGEPIMYPRINA
LVQELHRRGMSTFLVTNAQFPDAIRTLTPVTQLYVSVDAATKESLKAVDRPLFSDFWERF
LECLRLLRGCGQRTVYRLTLVSGWNMAEVDAYAKLLALGEPDFIEIKGVTYCGSSGASNL
TMKNVPYHHEVCAFGEALCGTEGGAGYAIACEHAHSCCILLARRDRFLVGGAWHTWIDYP
RFHALAAAGEPFTAADYTAPTPAWAVYGSPEAGFDPMEQRFRKARNHLSGAESECSSRSA
>A0A7S4ELX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudo-nitzschia australis|TrEMBL
MSRNTSQNNQVLLTTAVSLTVIALGTFWYRRQGTDLAASETNEDQERQQQHQPKERKQPK
VVRGAQRKGKTKEEEEKIEEYNYVDDNKDGNIDIHVPKQQPATFDAPILEIQARSIDTVP
EDEKEEHRSNRRQVLAPNTITIAHGSVTGTCSKLAKDLLACLQEKNLEHDRSIQMGSLEE
WDWWDELLNYEEEDDAKAKKGTTTTAEEQNPPVLLVLLPTHHGGSWPHTATCLESALQDL
KNDWRIEKRPLKDKLQVAVMGMGCSDYGDDTMGKPAKEAFIAFRKLGAKVFGQQVRVGDD
ATGNQDRVLQAWIHHDILPKLIIDDDDEDDEATQDGDNGGEPEVTDMEDLGTIMETSEND
EEGGEVKSSEPREMVTSTQAKSLKKEGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTFYG
ITSYQCMEATPSLACANKCVFCWRHHKNPVGKEWRWKTDDPHFIVDEAVKTHVKMIKETR
GIPGVDIQRWQEAHTVRHCALSLVGEPVMYPRINDLLGDLHDREISTFLVTNGQHPKAIA
DLIPITQLYVSVDAPTPESLIAIDRPLFSDAWERLQEALTLLKDKGQRTVARLTVVKGWN
SDEVEGYARLIALGKVSLVEVKGVTFCGKSDASNLNMSNTPWHHEVVDLVKNLKLELDKL
RLAGQDVPEYDLACEHKHSVSVLLARVDQFSETAPDGRRIWKTWINYPKFNELATKHKED
PSFTYGVEDYTAETPAWALFGSEEEGFDPVELRHRRKKKYPKYTKYDQKGVPTHDDNDEK
LSEEEYLRLNAIMDEKIKQVGCGSTVTALKGGEKVIQDASLMFRGLTIVK
>A0A0A0HS83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paracoccidioides brasiliensis (strain Pb18)|TrEMBL
MTGIVLGISPPVIRTNTLGLLSLWHKYRIPILFLAPVVLAVVRLLPKYPTSDPPHSSGSS
PLPSSKETINSGDVQERELLLSKTEPPLATLTKHDPSPSSSPDSDKRTKRRLNGPKRVHG
TKPLKNDVNRLSGHARLPRDIVIQPLVFYASLTGSTEAYAKSFCDRLQGAAQSSRNNGNG
TFLAPKLHDLSYIEFDDYFIAAPNPTHSAPNTKFFYCILIPTYNIDTMINTFLDHLNETH
NDFRINTSSLSGLIGYSVFGFGDGEGWPTEEAGFCSQAKEVDRWMAKLTGKKRAYPLGLA
DVKDENLQIILSDWCDGLSDVLSDLVALGGGLGEGVPGSGDPIESDEEEDIDGEPAENKT
NGGNRLKKDQEQRPIVDMEDIKFTISDEKTSADSQLLPIDFTTQSGTQSFKPAAQLEMVP
TSSPTHAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLS
CSNKCVFCWRHGTNPVGTTWRWRADPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAM
RIRHCALSLVGEPIFYPHINKFLELLHGEQISSFLVCNAQHPDQLATLDRVTQLYVSIDA
SNRESLRKIDRPLHRDFWERFQRCIAILREKRYFQRTVYRLTLVKGFNVDEEVVGYADLV
EKGLPCFVEVKGVTFCGTSTSARAGLTMKNVPFYEEVVSFVVALNAELSRRGLGYGIAAE
HSHSCCILLASNRFFVNDRWHTRIDYDKFFILLQREKSDGIQFRPEDYMRETEGWALWGN
GGFDPNDTRVYTRGKNKAKQNATIEESLAQGASVNG
>A0A8J8EIK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. ES12|TrEMBL
MAITFVSNPNMPEEIARLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSLTAPDLETYNRVNVPMIPDGWERIKTFLEMMNGLPTRTVVRLTLVKGE
NMHNPEGYAKLIRLASPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVEHLPGY
HIEDEYEPSRVVLIMRDDVDPHGSGRDGRFIKH
>A0A166EIH0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter filiformis|TrEMBL
MVLTKEEQEKLEYSGYRFAGQHSHAGAKICHWTKKSILNEGECYKQKFYGIESHRCLQMS
PAIPFCHQKCSFCWRDLSLTKTEWKGDYDDPKTIIDDCVKAQRNLLCGFFGNEKADKKKL
EESKDPTNAAISLAGEPTLYPEIDDLINEFEKRKFTTFLVSNGLLYEKLRALENEPTQLY
LSLDAPNKKTYNSICNPQINDGWTKLNRSLELLSSFDSRTCIRTTCVKGENMKNPEEYSE
LINKANPDYIEIKAYMCVGYSRKRLTLDNMPEHTEVRDFAEKIANLTGREIVNESEISRV
VLVK
>A0A497RSR7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MIPTEFKKILEKQHYKIVGRHSAVKLCHWTKRSILDEGFCYKQKFYGIESHRCLQMTPAV
AWCTQKCIFCWRNIEQTLGTKLDEFDEPEDIINEAIEAQRKLLSGYGGIPERINKTKFKE
AQDPNQVAISLSGEPTIYPKIGELIGEFNKRKFTTFLVTNGTLPERLEKLENLPTQLYLS
LDAPNEKIYNRICNPILSENWKKINETIVIFPSLETRKVIRITAIKGLNMLSEEGYARLV
QRAEPDFVEVKAYMFIGGSRKRLSLGNMPSFAEVREFSENLSSYLGYSIKDFKEDSRVVL
LSGR
>A0A7J2ICT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MIPTEVKKVLQHQHYHIVGEHSAVKLCYWTKRSILNRGYCYKQKFYGIQSHRCLQMSPAV
AWCTQRCLFCWRNVEQTLGIKLDRFDDPSEIVENSIIAQRQLLSGYGGIPDRINKKKFDE
AQNPNQVAISLSGEPTIYPRISELIEEFNRRDFTTFLVTNGTLPERLESLDPLPTQLYLS
LDAPDEEIYKRVCNPIIPDGWRKINETLNIFPSLNTRRVIRLTAIKGLNMLKVEKYSKLI
RIAEPDFVEVKAYMFLGGSRRRLTLENMPSFDDVRRFSEELSEELGYGIRDQKEDSRVVL
LAKNSCNRKIK
>A0A8C6HQ58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mus spicilegus|TrEMBL
MGPLDVWDLSPLLSLWMNRFYIYMGCALGLTLCICVQIIKKQVTRSQEKSVPGAPDSSLS
PQKKQTHVSGVKIFYGSQTGTAKGFAVVLAKAVTSLDLPVAIINLKEYDPDDSLIGEITS
KTVCAFLVATYTDGRPTESAEWFCKWLEESANDFRFGKTYLKGLRYAVFGLGDSAYRSHF
NKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQRGEK
KACGRNCKRGKCESAQHGPGEARPHPQGELHPGDAEEEEPCESSSEDSEDELGTQDYQSL
TSVVDVEDLGNIMNPVKREKREKSHQDGKAAMQRNPEKTEDGEGRAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILKEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEP
IMYPEINRLLKLLHQHGISSFLVTNAQFPEEIRKLIPVTQLYVSVDASTRDGLKKIDRPL
FKDFWQRFLDSLKALSAKQQRTVYRLTLVKCWNVDELQAYAELVSLGNPDFIEVKGVTYC
GESAASSLTMANVPWHEEVVRFVRELVDLLPDYEVACEHEHSNCLLIGHKKFKIDGEWWT
WINYSRFQELVLQYEESGGSKTFSSRDYMARTPQWALFGARERGFDPKDTRYQRKNKTKD
ISGC
>A0A4R8QJ15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum spinosum|TrEMBL
MAFSLDQPGLMVMLNDFHNVWQQVRIPVILFTLFGLLVLRLYYHSTEKKGELKVLPKVYN
REKPETEPKGLAVDEQQVVNEIVAVKKKELKPIPVAEPKPAKSSGPKRIKGGLVKRPSEE
LKNSEVAQTIRPLIFFSSITANTPKIAKEYAERLGKDLEKTATDTGCQFKTPEVLDLAEI
DFDDYFITPPKSEEPVELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGY
SVFGFGDREGWPTEEEGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYSERLAEWSEG
VVDVLGLVAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLVEEDAKPEKLKNSSKLEDVE
DLGRIMKSSQPDSAPVPAAPIAVDFTTYGKSTTATKKPTQAAKEMVPKNSPTYASLTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPL
HRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYARLVEKGLPCFVEIKGV
TYCGTSTASNAGLSMSNVPFYWEVSEFVTALEKRLNEMGLKYGIAAEHAHSCCVLLASDR
FYKDGKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGKGGFDPRDERVDRK
GRKIEA
>A0A672IHP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarias fasciatus|TrEMBL
MVLKKQNLSSEDVSFISKVERNSHQPHKEIEVHVSGVKIFYGSQTGTAKGFAQQLCQEVK
ALGLPAEVIDMKDYDPDDQLADECVSKTVCVFLVATYTDGRPTENAEWFCKWLEEASTDF
RYGKTYLEGLRYAVFGLGDSVYVGHYNTVRIRVSRHRSVINLSELHGERLVNRFTSIPPG
GEECGQVAVDAQRRAHHDQRRGRLQRGEEPQRQRPGGLPLLEGQVPQPSAGSGERREEEL
QRELQDWRLLQEQEERRGSSSDEDESGLQERKPGSVVDVEDLGNIMSTQFLTHVVPLCFC
AGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDPAHKILEDAVEKHQGMIRQFRGVPGVKPERYEEGLAVKHCALSLVG
EPIMYPEINAFIRLLHQQHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLASLRALGEKRQRTVYRLTLVKAWNVEEMLAYSELIALGQPDFIEVKGVT
YCGESSASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEGEW
WTWIDYQRFQELVEAHEESGGQRSFSASDYMAKTPSWALFGAREQGFDPADTRFQRRNKT
KDISGC
>A0A812A7S0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanoperedenaceae archaeon GB50|TrEMBL
MWEDLLESLEILSEKRRRTAIRVTLIEGVNDRDPGGYASLINRATPDYIEIKAYMHLGFS
RKRLERGAMPTHSKIKRFAQKIIEYTGYRLVDESEPSRVTLLSRDGKNEKIEREDAN
>A0A1Q5TQG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium subrubescens|TrEMBL
MASMPTTTDGLLAAWHTYRLPLLIALCTLFVALRAYRKVQSRSKTPTSSSIPSSPRSLSP
EKSPIPRVPTEKQPPLSIPTNNGKLAPNDEPPKSTSGPKRVQGKKPAKTVSGRRVNNEES
HPLSIQPVIFFASLTTTTERYANVLLEDLRAAAQERADLEKREYGLLPPQIHDISYIDFD
DFFAAAPKPPSTSPGTRYLYCILIPTYNIDTVLNMLLGHLDEIHNDFRIDTAPLSQLAGY
SVFGFGDKEEWPTEEEGFCSQAKEVDRWMAKLTGRKRAYPLGMGDVKSDAETSLKEWSRG
LQDTIFDILESGGLGEGVPGSGDAVESDEEDLGDLEDMDDESRSKKKTTSTMVDLEDIQM
NGDSAGPIPIDFTTVGKAVSAEPTAKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIKSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELI
FDGVKEGHYKKIKMLKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHVER
ISSFLVCNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHIQRTVFRLTLVKGFNVEDEVIGYANLVEKALPGLVEIKGVTFCGTSTSAGAGLTMKN
VPFYEEVSAFVVALNEELQRRGLKYGIAAEHAHSCCVLLASERFNVNGKWHTRIDYDRFF
ELLEKEKEDGTSFRPEDYMRETEEWALWGRGGFNPDDERVFRKGRDANSRARKAQEILGT
AITF
>A0A8H5JK14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium napiforme|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLALCVILVAIRTYFHVNGQKAEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A1J4JSX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tritrichomonas foetus|TrEMBL
MLSFFKKSKGMKAFQDSPLFHFLPNGDIICLCCQHKCVIPPGKLGKCRVRANIDGKPHSP
TWGQYTVCIDPVEKKPLYHFLPGSKVYSYGTVGCNFNCQFCQNSSLSMWKLDIEDVAALD
NSEGRKLAKHTPEEMVRDALRSGCLSIASTYNEPTVSTEYSYEVFKLAKAKGLKTIYVTN
GFESVETLNFIGPYLDAVNIDLKSFREEFYVKVLGGHLKGVCNTIKRCSKMGIHTEVTTL
LIPDANDSDEEITDIANFIAGVDKDIPWHVSAYHDDYKFSGRGRTPVSTLERAVEIGKKA
GLKYIYMGNVRTPEGRNTFCPKCGNTLINREWFDARPSLKKGTCKCGQVIPGVFVDAVNV
KPRVDHVPQELLDEPTTASVALAAGGNTDESTKDGLNFVAYASQGGTSKEFAEKIGQNLG
YKVIDFASLDVATLQAAKNAVFAVSTYGRGHPPATSREAWGKISEMTEKLPNLKFAILGC
GSSSFEATFVGFAKSVNEKLLSLGGTQVTPLCTRDENEDEDDEKVDQWITQLKFT
>A0A5J5SMQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium barbadense|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHRGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPQHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSAGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A226DES1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Folsomia candida|TrEMBL
MATINPPLKEKPRGIIAGLAGRIWYVAETLFSYGYAILESFVFIAFSGLFIAVRSYFIKN
EEDNLIVTSSGGGRNSVKKHVNIYYASQTGTAQRFAEQLFRDVEKMDDAVNCPGDLLSPV
KNLSLTEVEHLSELGLASSSLDSVGVAIFIVPTYEDGAPPDSAEWFFKSLAENAVDFRVS
KSYLKKMNYAVFGLGNSLYCDNFNKVAKQLDYNLAHLGAQRLLPLQLGNENSTESDFGSL
VADFNMWKRRLLKILLSNEAPAFHPLGGITSSSDKNSHPPQDEDLVESSSEDEAADDTVD
QPGTCGSKTEIKINQNNKTSSGDLVDLEDIGSLVITARKKIAREKQDFAEMGNLKEMVTP
ELRKALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIASHQCMEATPSLACAN
KCVFCWRHHSNPVGTEWKWKMDEAQMILDGALQNHYKMIKEFQGVPGVSRERIEEGLHAR
HCALSLVGEPIMYPEINKFVKLLHAKNISSFLVTNAQFPDAIRAMSPVTQLYVSVDAATK
ESLKKIDRPLFKDFWERFLDSLKEIKDKGQRTVYRLTLVKDMNVAELQNYAKLVELGDPD
FIEIKGVTYCGTSKASTLTMENVPWHEEVVSFSQSLCTNHLPNYELACEHEHSNCILLAN
KRIRLEMEVCEQLIKETFPQINEDIYAYVEGKWLIGILTVGREDFEDETQVFDAIGEMLL
EISNVGTTEEDVKAVCTTIYNTLGLGEQNRCNKNGIRKLDSTIQMSTLLSDDKLTDINSI
WMRNAGSNGQSLVDSKKLQKAEAKILQKQEKRAEGGGKPVVSLSTLMANQECQASAAQVI
SKKDNRVSAASGKITDIKIENFDVAFGDKVLIQGATISLAFGRRYGLVGRNGLGKTTLLK
MIAHKQLRIPPGISVLHVEQEVDGDDTPALEAVLEADAVRHHLLQEEKRLVALNSADAAT
ELNEVYAQLTAIEADKAPALASVILAGLGFAPEEQSRPTKTFSGGWRMRLALARALFAKP
DLLLIDEPSNHLDLKAIIWLENYLQSWQSTILVVSHDRQFLNEVATDILFLYQQNIEHYR
GNYENFVKTRGERLKNQQREWDAQQQLRAHTQEFIDKFRYNAKRASLVQSKIKFLERLPE
LRPVDKDGEVVLRFPEVQPLNPPVLQLDDVVFGYTKDKIVLNRVTISAGSDSRICVVGEN
GAGKSTLLKLILGDFPPTGGLVMTHRGIRFGYFSQHHIDQLSLDLTPVGLLQQKFPGATV
EEYRRQLGRFGVSGDLALQSIASLSGGQKSRVAFTAIADTQKHPKFISGKMTTALCLYSL
IFMRFAWKVQPRNLLLLACHITNECAQLTQGARFIQYEYMGGKEKDPETVLTTTTSSSQP
QPQK
>U3IWF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anas platyrhynchos platyrhynchos|TrEMBL
CDTTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNSV
YVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFLSCLQAL
CRGERKPCSGKCKKGKCKSQGKQSKESSDHEHGASEYENAEAELVETTSEEEADAEEVGG
TNSVIDVEDLGNVMSHMKKAKLEEGHVGTSLSGETAGRKEAGEKREMITAALRDALTKQG
EVLSAWAVVLEAMTAKHCALSLVGEPIMYPEINRFLKLLHQHNISSFLVTNAQFPDEIRN
LEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNV
DELRAYADLVSLGKPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVQELVELIPDYE
IACEHEHSNCLLIAHKKFKVDGEWCTWINYERFQELVREHERSGGSKTFTAADYTARTPH
WALFGSSQRGFDPLDVRYQRKSKAKDISGC
>F6D1Y3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)|TrEMBL
MLLSDKDIQNLEKKGYRFAGNERHAAAKVCHWTRKSLVDEGVCYKEKFYGIQSHRCLQMS
PSIPFCHQKCLFCWRDVLITGTTWNEDFDEPKKIIDDCIDAQRNLLCGYFGNSKVNMKKL
KDAQEPNNAAISLAGEPMLYPKIEGLIEEFKRRDFTTFLVTNGMTPSKLKNMETEPTQLY
LSVDAPNKDVYKKLCDPQVDKGWERLNKSLDLLSSFKCRTVIRTTCVKGYNMLKPEEYAD
IIERSNPDFVEIKAYMYVGSSRERLKLENMPFSSDIHEFAESVAKLCGREIVNESRESRV
LLLS
>A0A523SP88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MISLQSLVSNKLIQLLKKQKYHLVGRHSAVKRCRWLYESLVHNRVCYKQRFYGIKSHQCL
QMTPTLFYCTMHCRFCWRAQSGDHGLKWSETQLPEWDDPEDIIEEAIQEQLKILSGYKGN
PKANQEKYKEALTPKHVAISLTGEPTLYSPLDRLIQGFHKRGFTTFVVSNGTVPEVLSRL
SEEPTQLYISVSAFDKKTFLKTCRPQISAAWEKLNETLSLLPSFKCPTVIRITLARNLNL
EHPELYAQLIRKANPTYVEPKAYMHVGFSRLRLGFENMPTHREIQKFAGQLTKEMDYNIL
DESPQSRVVLLSRLEKPIKLSG
>A0A812NAZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium sp. CCMP2592|TrEMBL
MNSNWTSRTCIGDDYRWMYASPRVAEENISMPIPPGQAGGASPSSHSISLFKSAFGWCPE
VTSFEATPFVGKNGVFLVDVGSHSGPAQEVPGSGQINWPNSITTLNASVFGFAAVAVGNG
FLVPTHTTGGVYVMEASTRPSTLQEPVKISKDLSGWFYHQAHFVDMDGDGLLDVLTARCE
YAVWPWAKKRGELVWLKQPAKDALAGPPWEEHELGAGPDFLFCVHPNSSRLALVAPEFVS
GRVVYWFMQQNGTMSSRLLDDTIGPGFSCSWTDLNADGHLDLLVTNHAAVNGSVFAYSFS
SDDIASAQITRHVLATGFTPAKIDKGKASPGDALAFQPHINSTDKPYIFVSGDNSNSIFL
LTPVSKDQSDWTYSLEEVQDFGADIGRPSIGDVDGNGFADIFVPVYDSKRVVHYEFRRGL
AWRLGPGRDRELKLRADAGAPPEAAPSECGSCMPPCQEHPRQQQWRWRSPSAVLCQRLRF
LLRQSCRSASRTCRPLHSTPCSPVRTDAVSTDIVALLLSTYTDGLLPPSSAHFGTLLADH
VHDFRVGRSAMSHLHFAVMGFGSSVYADAGHFCTAAVRADAALAALGGLRVARLLRVTDT
KELANQASEWQLEMQSAISAALRGVEIPKAPGIEGNAAAEAAVSQTADQEGGEASSDSED
DSSTTVSSGEAAAKGSTSDVEELAEGCAGDTVKKPEERQMLTTKHRAQLTKEGYKIVGSH
SAVKLCRWTKHQLRGRGGCYKHSFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGTEW
KWSMDPPDQIVAEGIDQHRRMIRECKGIPGVKKERFEEAMTVRHCALSLVGEPIMYPRIN
ELVGELHQRKISTFLVTNAQFPEAIRNLDPITQLYVSVDAGTPETLKAVDRPLFSDFWQR
YLDSLKALKAKKQRTVYRLTLVKGHNMEEAANYAKLVALGTPDFIEIKSVTFCGESKASS
LTIGCTPWHEEVKAFSEAMLSKEGLESQYELACEHQHSCIVLLANKRYKVDGRWHTWIDY
DRFHELVKAGVEFDATDYWAPTPEWALYGSEEAGFDPNETRVYHNRTKKRAQAGLLSKEQ
LKMYPDNPAKQ
>A0A523BDN4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MVGRHSAVKTCHWVRKALTEGKICYKGRFYGIETHRCLQMSPAVVYCTNRCVYCWRPLPG
ERGFEWAGGRIPAEDEPNEIVDGAIEAHRRALSGYKGNPKVPEERYEEAIRPRHVAISLS
GEPTLYSKLSDLIEEFHRRGMTTFLVTNGTNPRALEGLKEPTQLYVSVSAPSEEVYRRVC
RPCAEGNWESLMRTVSMLKTFKCPTVVRITLVKGLNMEDPDGYARVLNMGNPTYVEVKAY
MHVGSSIWRLGAEAMPSHEEVLEFAGEVAKRSGYDLVDEVPASRVALLSRVSKRVPVCED
RRDSLRDKQNA
>A0A7J3NPL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVSVKSKEALIPLAVASVLKKQKYQLVGRHSAVKRCHWFYRALTGRGYCYKQKWYNIKSH
RCLQMTPCAIFCTNRCLSCWRLEPGDLGFEWDQMAILKEDVDEPEEIVDECIKAQRRILT
GFNPVHHPLVSEKMWREALEPKHAAISLAGEPTLYSKLGDLIETFHKRGMTTFLVTNGAV
PERLAEIEEPTQLYLTLYAPSEGVYKQVCRPLLKDAWNRVIESLALLKSFSCPTVVRLTL
VKGLNFMEPEGYAKLIELAEPTYVECKSYVSVGMSLRRGLRNGNMLKVDELRPFAEKIGE
KLGYNIIGESVSSRVILLSRLSKPIKVA
>A0A419QJQ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MRFSVIFNFLLLLLGFRLIGLQVSVKDILISRFKREKYQLVGSHSAVKKCNWLHQSLVRG
KVCYKQKFYGIQSHRCLQMTPSAFYCTLRCLFCWRVQPEDLGLKFDEVSFPEPDNPEFIV
EESVKAQRRILSGYKAHKEIDTKKYLEALNPNHAAISLTGEPTLYPLIGDLIAEFHRKGF
TTFLVTNGTNPKALSNLSHEPSQLYISLHAPNEKVFAQTCRPQIANAWKNVLESLSMLKS
FSCPTVVRLTLVKNLNMVKVEDYAKIILNAEPTYVEAKSYMYVGFSRKRLAYENMPTHEE
IKVFSEELSNLTGYKILDEARDSRVVLLSKKDKPLRIGKQ
>A0A550GZM9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPPALLQVLKKHKYHLVGKHSAVKRCKWLYESLIHDRFCYKQKFYGIKSHQCIQMSPSIF
YCTQHCMFCWRAQSGDLQIKWDELELPNWDSAEEIVEESLKAQIKILSGYNGHPKANWKK
FTEALTPKHVAISLAGEPTLYEPLGKLIRMFHNKGLTTFLVSNGTAPSKLAELSEHPTQL
YISVCAPNEQVFKRVCRPQVPKAWAKLNETLGMLRNFRCPTVTRMTLVKGLNMEQVDDYA
ELVERGEPTYIEAKAYMHVGFSGIRLGYNNMPSHEEVHNFAKRLAERTGYMIIDEATESR
VVLLSKLGKSNALRPPEQEDNICK
>A0A8B9YGI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus grunniens|TrEMBL
MDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISHPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALCKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHLSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>K0B5Q2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosopumilus koreensis AR1|TrEMBL
MSCSGEVVDNEEQLIQIKPAISEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPKEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLGMLKHLNTRTVL
RITLIRNYNDQKEMIPAFAKMFKESSPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKKFS
EQVAKQSQIFSVMDESFVSRISILQNNKRFIDRWIPAYANTN
>A0A6P5E2E8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos indicus|TrEMBL
MTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDDR
LIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLGN
SVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRLQ
ALXKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESDT
EDHQSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSLK
KIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQR
KNKSKDISGC
>A0A1D8S6I8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halodesulfurarchaeum formicicum|TrEMBL
MTQQVSGPNYHTVDHTAVQTCGWTKNALRGEGTCYKHRFYGIRSHRCVQMTPVVRCNERC
VFCWRDHAGHTYELDGVDWQSPEAVVEASIDLQRELLSGFGGNDDVPDERLEEALDPQHV
AISLDGEPTLYPHLPELIEAYHDRGFTTFLVSNGTRPTVLEAAEPTQLYVSVDAPDRETY
ESVVRPREEAAWDALDESLDVLAAHDSRTTIRTTLVAGENMHDPAAYADLYRRAAPDFIE
IKGYMHVGTSRDRLDRSAMPDHEEVVDFARSVQDHLPAYDVFREAPPSNVAMLSTDPETV
VPELAE
>A0A8H7ANA8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Endocarpon pusillum|TrEMBL
MDMEERHLWPVLVADRIDQILSMWHTHRTPVIALVLTALLLLRAYLRRTTKFKDPNSSSN
PSAPLLLKDDEKPPWSSQDPEKLETVSSRERRVSLQRSAGPKLVTGRRPLKERKNENTKQ
SGGQLRVQPLVFYCSLSGRTAQLARSVVSKLNASLTRDGSILPSELHDISYIDLDDFFIS
GPKVRPSAGDVRYFYCLLIPSYNIDTIMTNFLSHLDETHNDFRIDTAPLSSLLGYSVFGT
GDKEGWPSEIEGFCSQAIEVDRWMAKLTGRKRAYPLGLGDVKGKLQESLHEWTVGIQYTL
YDLSITGTLGEGVPGSGADLESGDEEEADFPDSGRQKRQKTEQVADLEDVRGPVNGPLPI
DFTTTTSYLSSAPTLREMVPKTSPTYAALTKQGYTIIGSHSGVKICRWTKSALRGRGSCY
KNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPRMIFDGAKKGHYQ
KIKMLKGVPGVRAERFEEAMRIKHCALSLVGEPIFYPRINEFVGLLHDEGISSFLVCNAQ
HPDQLASLQRVTQLYVSIDASNRDSLRRIDRPLHRDFWERFQKCLDIIREKRFVQRTVFR
LTLVKGFNIEEEVEGYADLVQKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVVAF
VEALNAALARRGLEYGIAAEHAHSCCVLLASNRFFIDGKWNTIIDYSRFFELLERGEDFS
PEDYCLPTPEWALWGKGGFDPADQRVDRKGRPKVAEAVGYSGHVAQTIAQPA
>A0A2E1MD18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDSLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLDAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFYKLEETLELLPSLDTRTVCRHTLIKHESMGYHDDYARLDNIA
DPNFIEAKGYVNVGNSRNNLSIENMPTHQEVLEFSQKLAPMVGREVLSDRRESRVALIGK
EMIPVELPVANTELPKDLGIAKPQRFLLPQA
>A0A2E9KN55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFHKLEETLELLPSLDTRTVCRHTLIKHESLGFHEDYARLDNLA
DPDFIEAKGYVNVGNSRNNLSVENMPTHQEIIEFSEKLAPLVGRKLLSDRRESRVALIGK
KMIPVDLPIASMDLPKDLGIAKPQRFMLPQV
>A0A2D7Z9B8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDDKLKATLQKQRYHLVGEHAGVKACHWTKESLLRDRSCYKGVFYGIESHRCLQMAPVVD
QCNLACSYCWREPHMDSLEASKDDPFEMLEEAVRGQRRLLTGFKGDPRVKTEKWEEAQTP
KHVAISLNGEPTLYPRLGEYIQHCHDHGMTTMLVTNGTLPKVLEGLDPLPTQLYVSVDAP
NEEVWNRLCKPKFGGGQWKRFEETIDLLPRLDTRTVCRHTLVKGENMTQVEEYAALDNRA
DPDFIEAKAYVFVGHSRQVMSLANMPRHEEVMAFARELAPLVGREVLEEVSASRVALIGK
EKKKIVNPEPNKEFRLDLGVAPPIKKLPLI
>A0A7J3C614|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDQMRKKALEKQGYKLVGEHSAVKLCHWMRQSLYYDRPCYKQTFYGIESHRCVQMTPAVD
WCSENCTFCWRAQGWQGDKIPQEDEAADILEGSITAQRELLTGFKGDSRTDMKKWLDAQQ
PKHMAISLTGEPTLYGKLDDLLAEAKKRKISTFVVTNGTNPEALEKLTVLPTQLYVTVAA
PNEKLFNEILNPIYKDGWERLNRTLEMLPSLDTRTVIRHTLVKNFNLGYVEEYYRLDRKA
DPDFIENKGYVHVGGSKNRLSITDMPSHEEIRDFSFRLNGYLNYDFGGERVDSRIVLLSK
DRRKNMIDFSAL
>A0A2E8S4Z9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPKLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRGRQCYKGRFYGIESHGCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMEXCHKHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKTVFDDICKPKWNQGAWEKFEQTIDLMPSLDTRTVCRHTLIKGKNMSLEHIREFAELDN
RADPDYIEAKGYVHVGHSQENLAASNMPSHEDIMAFSHEIAPLTNRQVLDESRPSRVALI
GTEIIPIQVPEAEMYFPEDLGIAPPVKHLPVI
>A0A8H5ZV06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus burnettii|TrEMBL
MAEVSFIEGLLTFWHSYRLPILIAVTSVAIVLRVYQKSQPKSKAVSASSIPPSPRSQSPD
KFEKVCASNSEKLVVTEKSVPNSAVGNESAPKVASGPKRVSGKKPLKVAGRGRGSDQGPP
VSFIQPIIFFASLTGTTERYAQVLLEDLRAAAKERADPENRDRGLLPPQIHDLSYIDFDD
YFTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYS
VFGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKNDAESALKEWSRGL
QEILLDILNNGGLGEGVPGSGDPLESDEEDLDDEENDGKRSKRRNGQDVVDLEDIKMGSS
DGQAGSGPVPVDFTTTGNSVAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPD
LIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHN
EHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDIL
REKRHFQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCLIEIKGVTYCGTSTSAGAGLTM
QNVPFYEEIQEFVLALDKELQGRGLDYGIAAEHAHSCCVLLASKRFYVNGKWHSRIDYDR
FFELLEKEKADGTPFRPEDYMKETEEWALWGNGGFDPNDERVYRKGKKKALQAPTE
>N1PG76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dothistroma septosporum (strain NZE10 / CBS 128990)|TrEMBL
MDSENYLQLPREILLLWHTHRTDILIGAAVVIGLVRLAIHWRGRRLKIALTPPLGTPVIE
KKETFAVEDEKEGPRYTAIDHKAVPATISKGPRRIQGKRISRPKQEAGAAIDQIQPHVFY
FSLGGSTRDHAVKLAEALSLTEDTERILPPAVHDLTEIDYEDYFVSAPKSSAPNAATFYM
ILIPAYNIDTELSNFLSHLEETHHDFRIDTAPLSGLAGYSVFGFGDQSEWPTEQVGYCQQ
AIEVDKWMARLTGRKRAFPLGMADVKGDELGQRLADWRRGVGTIMQDLSQGKGLGEGVIG
SGEAVESDDEDAADYEDDETMVGNPRRTRRVSDDLEDMKAPVPVDFTTVGRTTATLQAPK
EMVPKTSPTYANLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHLCMEAT
PSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPDLIFTGMKEGHYQKIKMMRGVPGVRSERF
SEAMRIRHCALSLVGEPIFYPHINELLAMLHKEHISSFLVCNAQHPDQLAALGPITQLYV
SIDASNKESLRKIDRPLHRDFWERFIRCMDILCEKRYTHRTVFRLTLVKGFNIEEEASGY
ADLVERALPGFVEVKGVTYCGTSTAAGAGLSMQNVPFYEEVQRFVLALEAELNRRGLDYG
IGAEHAHSCCILLADRTRFNKNGKWHTTIDYPAFFKCVESGKSFSPEDYIGAATPEWALW
GNGGFDPRDERVDRKGNPKEVKAVEYPPGSVPQPKVVEI
>A0A178C1E2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fonsecaea nubica|TrEMBL
MDLGEAGAAPVILADWLDRLLNYWHENRAVVSTLVGLCVLAVVVQRRHASKSAQHGSPTL
EKAAWLAPEDGARVQIGKDQRLQSPSRISPSLTSGQARKPRTPAAAARVVTGRKPASSRG
QAALQRRREPSRMQPLIFFSSLTGTTERLAKQVAADLEGVSTAYPAILRPQVYDLSYVDL
DDYFISGPKTPVPSADVSYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLSTLAG
YTIFGIGDKEGWPTEEKGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKSNVDKSLKDWVG
GVCNVLKEVSKTGALGDGVPGSGEPVESGDEDEPEDGDEETDEFPDSGRNKRRKLANTTD
LEDVGGKANSYAPPIAIDFTTYGSRPAPATTLKAMVPKESPTHAALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQ
VDDPKLIFDGAKEGHYKKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPIFYPRINEFV
GLLHGEKISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFNS
CLDILREKRFVQRTVFRLTLVKGFNIEDEVEGYAHLVAKGLPCFVEIKGVTYCGTSSSAG
AGLTMQNVPFYEEVVAFVEALDKALAKRGLEYGIAAEHAHSCCVLIASKRFLIRDKWHTL
IDYDRFFDLLQSSADFTPEDYCKATPEWALWGNGGFDPRDERVDRKGRPKEKKISGGDDD
DTVSEARSGIKAAEQKAELDF
>A0A7L4QRC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MSSTSLSRSSRARGRRKTAASPWCWRRKILSRRHSRPLALKPSPPCKALRTQGYQFVAPD
SSAAVKPCLWCKKALKGGAKCYKNQFYGVESHRCVQMTPTLRCNHRCLFCWRSFEHEYPG
ERECTPEEIVRKIPDLQKRALSGYKVSPYVTAERFSEALSPKHVAISLSGEPTLYPHLPE
LIDLLTREGYSTFLVSNGTRPWVIERCNPFQTYISLPAPDRDSYLRICRPEDDYWDRIGE
SLSLLGTRRSAIRITLVQGHNTFAPEKYAAILQDSGATFVEVKGYMYLGYSRKRLGRENM
PQHEDVRAFAGRVAGHCDYRITDENPASRVVLLERDV
>A0A1T3CAZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma guizhouense|TrEMBL
MDAASRLQLEAMVADLVEVWHIHRTTIILASLFLLAGLRIFLHTTEKREPLAALPKIYSQ
ELPKTSEKPIVKAQPVVETEKKSTGPRRIKGKLTRKSSQEGKAATNESTDRPAKVLVFFS
SVTTKTEKIARDYINALETFVDQKAKETDGKFLKPELLDLTEIDFEDYFVSPPKSAEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKDLDKWMSKLTGRKRAYPVGMGDMKSDHAERFTEWTSGVQDVIAQAAQTGFLGEG
VPGSGDAVESDDEEAEADDGEVVFDDEEPSEGRKSDDSRPLDDVEDLGKMIRTKDGNEGT
RKAPLAVDFTTYTSANKKKAQAPIVKEMVAKDSPTYTALTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLI
FDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHNER
ISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILRE
KRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMSN
VPFYWEVCEFVKALDKRLAEKGLGYGIAAEHAHSCCVLLASNRFNVDGKWHTHIDYQKFF
ELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>M0C867|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena limicola JCM 13563|TrEMBL
MSDSAPSGTDADDDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIFYGIESH
RCIQMTPVVRCNERCVFCWRDHNGHAYELDDVEWDDPEAVVDASIKLQKKLLSGFGGNEE
VPREVFDQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLAECDP
TQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMAVLADKDETRTVIRTTLVDGENMHHP
DWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSSMPDHEDVVEFTESVAEHMPEFDEVMG
VPASRVALLSKTSDTWVPKLKKDSEFWNRDPVTGE
>A0A8J4QDP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Castanea mollissima|TrEMBL
MSLSSVSARLTLLALLSASTFYCFYESRRLRKLKLSLQNPKPDRSVSKPKLFFVSQTGTS
KALAQRLFDLLAINDLAFDLVDPKDYEPEDLPKETLVLIVASTWEDGKAPASAKFFANWL
AESADDFRVGSLLLSNCNFAVFGVGSGAYGATFNSVARDFSKQMRAMGAREVLPVWEGDV
DSGDVDEVFDAWSVKVVGFLKHGGVVENGGGEVLVSESDGESVADDEDSEEEEGGDEGSE
IVDVEDIAGKVPSRKKAVAVAETNGKLNGKKDMVTPAIRASLEKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
LEIVNSAIDLHTNMIKQMKGVPGVTLERLMEGLSPRHCALSLVGEPIMYPEINTLVDELH
RRRISTFLVTNAQFPEKIEMLRPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKA
LREKQQRTVYRLTLVKGWNTEDIDAYSKLFSIGKPDFVEIKGVTYCGTSATSKLTMENVP
WHSDVKAFSEALAQRSQGEYEVACEHVHSCCVLLAKTDKFKVNGKWFTWIDYEKFHNLVA
SRKPFSSMDYMAATPSWAVYGAEEGGFDPGQSRYKKERRHKSSTD
>A0A834B707|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phyllostomus discolor|TrEMBL
MGPSLDSWDFSPLISLWINRFYVYLGFAFAISLWICFQIAIRKQLFIFKDKNSQKKSVPK
ATRDLMTNGYISHQKKEVFVSGVKIFYGSQTGTAKKFAAVLAEAVTSLDLPVAIINLKDY
DPDDNLVEEVTSKSVCAFLVATYTDGRPTESTEWFCKWLEEASSDFRFGKTYLKGMKYAV
FGLGNSVYVGHFNKVGKNVDKWLWTLGAHRVMTRGEGDCNVVNSKHGSIEADFRAWKTKF
VFQLQVLLKGEKKSCDGNCKKGKCESHQHGSEEVEPGSHTQDGLRQRDTEREKEQQEEKT
GLFRNTVKKEAGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILKEAIENHQNMIK
QFKGVPGVKEERFKEGMTVKHCALSLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPV
EIRNLTPVTQLYVSVDASTRDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVK
AWNVDELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVRELVALI
PDYEIACEHEHSNCLLIAHKKFKIEREWWTWIDYNRFQELIQEYEDSGGSKTFGAEDYMA
KTPPWALFGANERGFDPKDRRYQRKNKSKDISGC
>A0A667YXX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
YSTLMGLPPPFHNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLRGLRYA
VFGLGNSVYVGHYNTVGKDVDKWLWMLSGMRILTRGEGDCNVTKSRNGSVQADFQAWKVK
FLSRLQDLAKGEKKSSTGSCKSGSGSCKSRTKRSQGQSEEEKAALHDNFEVMMEERSIKF
LILLVNGVKKIENEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCY
KHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKILQDALEKHQN
MIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRISSFLVTNAQ
FPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEKRQRTVYRLT
LVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLA
DMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSGGQRSFSALD
YTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A2T4GCN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium culmorum|TrEMBL
MDWANHSSHSRLDSFVDELVDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEHVEIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPLVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKGHGDTDLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A2V3JDZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanophagales archaeon|TrEMBL
MGRRDTSRLNYDEAPMRRLERQGYHFVGAHRHSAVKTCLWLRKSLRGEGNCYKGKFYGIS
AHRCVQMTPSIFCNQRCVHCWRPLEAFNLKGKEKEEAVIWDSPDEIVDECIREQRRLISG
FKGSPRTDPGVFAEANQPRHAAISLIGEPTLYPYLEELIEEFHARGMTTFVVTNGTNPEV
IRAIRPTQLYISLNAPEESIYKKIAHADYWDYIIQSLEELRNKRERTVVRITCIEGLNME
NPEGYAALLQLAKPDFIEVKAYMHIGYSRMRLPRTAMPTASRVRDFATEITAYLVESGYR
IVDESEISRVVLISCRDNRRII
>A0A8H4NKX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium acutatum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILMTVCVILVAIRTYFHINGQKTEIVAFKKV
YEEPVKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNEEEEKDLTRSVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRRFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDIEDITEDEDDGEVVFDDEEPRKKSKSARNLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKVVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPA
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A5C0XRW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)|TrEMBL
MDIKPGKITVQANPNMPEEIANLFRKQHYELVGRHSGVKLCHWLKKSLTEGRFCYKQKFY
GIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTEVPEPWDDPAFIVEESIKAQRKLLVG
YKGNPKVDKKKFEEAWEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPES
LREMIKDDKLPTQLYVSLTAPDIETYNKVNIPMIPDGWEKILEFLELMRDIPTRTVVRLT
LVKGENMHNPEGYARLIMKARPMFVEAKAYMFVGFSRNRLTINNMPSHEDIREFAEALVK
YLPGYHIEDEYEPSRVVLIMRDDVDPSGTGLEGRFIKH
>A0A180GIW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia triticina (isolate 1-1 / race 1 (BBBD))|TrEMBL
MLSLVESITNRLNFGNKPAIIDPYHTPLNTQILYSSLSSTTKKLANQLLIKLQSSSQHLN
SKLDSLDHLDLDQLITQTPVDSTHQLVILLLPSYNVESPVDSVLAQFRDALFDFRLSKNS
LAGLSFAVIGIGHSDYADEFCKQAIELDEILEGLGARRVIPLQRIDVSIDPERDLDVYYH
SILANIFRPSVKSFSELPTVKSQQLKYSSEDEEEEEDSNNSDDEFVDYSNSKPLSKAEKA
RQKSKRLLGKKMNQGEKSSKGTLDIEDLGVGVPQIENLISNSKDGEDQMIKKDMISPMTR
KSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLACANKCT
FCWRSHTNPVGTSWRWKTDDAQFVVEESLKEHDRLIKQLAGMPGVRPDRFNEARTPRHAA
LSLVGEPVMFPHIKKYISLLTEKRISTFLVTNAQFPESLLDLPPVTQLYLSIDAGTKESL
KSIDRPLHRDFWERFLESIDIVRKKRIRTVFRLTLVKGENSDEIKEYAELIRRGQPDFIE
VKGVTYCGYPGSSNLTIKNSPWHNEVIKFVEDLCEEINDPRYRSSQDQGPIAEYGLAAEH
AHSCCVLAAHQKYYFDDQWHTWIDYNKFFELVEAGQKDFEGLDYCDVTPEFALFGSPQAG
FSPEDQRWFRKKTLAKNNQLDQVDDPSSAAAAAAATTEHEQDL
>A0A7L1H9Q0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nycticryphes semicollaris|TrEMBL
LDVSMDTWDFFYTCLVSLWLHRFYIYSAVASGISIWIVAQFFTTKTKKKGNPASSEGTED
KLLNGHGTLQANEVYVAGVKIFYGSQTGTAKKFAASLAEAVISLNLPVEVISMGDYDPDD
CLVDETTSRSICVFLVATYTDGQPTESAAWFCKWLGEAATDFRFGKTYLKGLRYAVFGLG
NSVYVDHYNMVGRSVDRWLWMLGASRILTRAEGDCNVAQSKHGSIEADFEAWKAKLLSRL
QVLCRGEKKPCSGKCKKGKCKSSRKQSKESSNHEHGASEHENTEAEELFDTSSEEEADAD
EAGGTDSVVDVEDLGNIMSHVKKAKVSLLERVQNVRDLSPIIKIDGLIYFLFPGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WQWKMDQPEMILREAIENHQNMIKQFKGVSGVRADRMEEAMAVKHCALSLVGEPIMYPEI
NRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTRESLKRIDRPLFKDFWQ
RFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELIALGKPDFVEVK
>A0A0C4F8I3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Puccinia triticina (isolate 1-1 / race 1 (BBBD))|TrEMBL
MLSLVESITNRLNFGNKPAIIDPYHTPLNTQILYSSLSSTTKKLANQLLIKLQSSSQHLN
SKLDSLDHLDLDQLITQTPVDSTHQLVILLLPSYNVESPVDSVLAQFRDALFDFRLSKNS
LAGLSFAVIGIGHSDYADEFCKQAIELDEILEGLGARRVIPLQRIDVSIDPERDLDVYYH
SILANIFRPSVKSFSELPTVKSQQLKYSSEDEEEEEDSNNSDDEFVDYSNSKPLSKAEKA
RQKSKRLLGKKMNQGEKSSKGTLDIEDLGVGVPQIENLISNSKDGEDQMIKKDMISPMTR
KSLTKQGYAIVGSHSAVKTCRWTKASLRGRGFCYKHAFYGIQSHQCMEATPSLACANKCT
FCWRSHTNPVGTSWRWKTDDAQFVVEESLKEHDRLIKQLAGMPGVRPDRFNEARTPRHAA
LSLVGEPVMFPHIKKYISLLTEKRISTFLVTNAQFPESLLDLPPVTQLYLSIDAGTKESL
KSIDRPLHRDFWERFLESIDIVRKKRIRTVFRLTLVKGENSDEIKEYAELIRRGQPDFIE
VKGVTYCGYPGSSNLTIKNSPWHNEVIKFVEDLCEEINDPRYRSSQDQGPIAEYGLAAEH
AHSCCVLAAHQKYYFDDQWHTWIDYNKFFELVEAGQKDFEGLDYCDVTPEFALFGSPQAG
FSPEDQRWFRKKLLLKTTSLTKLMTPLLLLLLLLLPLNMSKIFEPSAFFV
>W7FUN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum Santa Lucia|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYKNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDTSNTNDTNN
TNIMNNTNNTNIMNNTNNTNIMNNTNNTNIMNTNNTNIMNNTNNTNIMNYTNNIRTGENC
VSESETSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCR
WTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKA
EIIVEEIIKKHKAMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELH
KRNISTFLVTNAQFPQELENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKI
LKNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQN
IPWHEEVYQFAWNLINKKKALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFH
QLVKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A8H6N5H7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum sojae|TrEMBL
MALPNDQFGFKAMLNNAHDAWQEIRVPVILFTAFGLFILRFYLHSTEEKSELKALPKVLG
REKKPETKSKPVEEKKDAKPKPIPTPVPESKAAKSTGPKRIKGGLVKRASEELKDGEPLA
RRIRPLVFFSSITANTPKIAKDYAERLENELQKTAADTGCSFTTPEVLDLAEIDFDDYFI
TPPKTEEPVDLVYLFLLPSYNIDTINDTFLEHLKETHHDFRIDTAPLSPLLGYSVFGFGD
REGWPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYKERLSEWSEGVVEVLGM
LAKTGSLGEGLPGSGAPEESDDESAAEDDEEVLIEDAEAKPEKLKSRKNIDDVEDLGRIM
KNSQPDTEVKSTSAAPIAVDFTTYGKSATQKKTPTQGPKEMVPKNSPTYASLTKQGYSIV
GSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVG
TTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYP
YINEFLGMLHAERISSFLVCNAQHPDQLATLKAVTQLYVSIDASNKESLRKIDRPLHRDF
WERFQRCLDILREKRFKHRTVFRLTLVKGFNVEDEVEGYAQLVEKGLPCFVEIKGVTYCG
TSTASNAGLSMSNVPFYWEVADFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKD
GKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKI
EA
>A0A6P7THZ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Octopus vulgaris|TrEMBL
MLEELLQYEVSEYLRLPVWLLLLAVISFTYLSRFWMKQTKTKVAEVKESVEKTVSKDCKT
EVKEWKRSLHILYGSQTGHSKILAESLAQNAEQQGVQVEVLNIKDYDPEDHIKHFKSPDR
IYVIIISTYVQGSPPDDAVWFYKWLKETAVDFRVQKNFLEGMIYAVFSHGNSEYKENFSV
VGKNIDAWLHQLEANRILPVGIGDEDTTQSSHGGLTEDFNAWNKKFWKKSIPVLKGGTLP
VESNKCCKETCEKKCCDKDNNSSNQEVLMETSSEEEEDDADNIESSGSLPVTQSNGLVDL
EDLGKVMKHVKKTKTKPEINGYIVSTNKQTKNEEPKPMITEIFKKSLEKQGYSLIGTHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRW
LMDDPEYIFKGAIANHTKMIKQFRGVPGVLPERFNEGMSPKHCALSLVGEPIMYPEINKF
IDLLHNKEISTFLVTNAQFPDAIHNLIPVTQLYVSVDASNKESLKKIDRPLFRDFWQRFQ
DSLLALAEKKQRTVYRLTLVKGWNTDEIEAYANLVDYGKPDFIEVKGVTYCGESKASTLT
MKNVPWHEEVCGFVQQLADLLPDYEIACEHEHSNCLLVANKKFKVNGEWWTWIDYEKFHE
LVQNRKNNSEMIFTAEDYMAKTPDWAVYGAKEHGFDPSDKRFFRKKQKDISGC
>A0A7L3F7K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zapornia atra|TrEMBL
LDVSMDTWSFFHACLVSVWLHRFYIYSAAVLGISLWIAALFFTTKNKGRKSSRHPAAPEG
TGDKLVNGYVTLRAKEACVAGVKIFYGSQTGTAKRFAKALSEAVTSLHLPVEVISLGDSD
PDDRLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKMYLKGLRYAVF
GLGNSVYVDHYNTVGRNIDRWLWMLGARRIMTRAEGDCNVAQSKHGSIEADFKAWTAKFL
SQLQALCRGEKQPCSGKCKRKKCKSQGKQSKESSDHDHGASECENTEAEELFETSSEEEA
GAEEAGGTSAVMDVEDLGSIVSHVRRAKVQLCRAAGTSSTQGNLGRKEEGEKREMITLAL
REALTKQGYRLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEALENHQNMIKQFKG
>A0A8E0QSA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus udagawae|TrEMBL
MLTDSSFIGLLAFWHSYRLLFLVALSTVFLGLRFYRILQSRTKTTASSSIPPSPRSQSPE
KTDKGTSLKSSNPATTQKAERQLPLANGPAKGTSGPKRVTGKKPSKVTGRQGQTEDAEPL
SFIQPIIFFASLTGTTERYAKILFEELRAAAQKRADLQDRERGLLPPQIHDLSYIDLDDY
FTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTVLDHLNETHNDFRIDTGSLSSLAGYSV
FGLGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGLGDVKSDAESSLKEWSQGLQ
DILFDILENGGLGEGVPGSGDPVESDEEVDDEDVDKSNAQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSGQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFEGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGERISSFLVC
NAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTFCGTSTSAGAGLTMQNVPFYEEV
AQFVTALDAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKEK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDKRVYTKGKKKNMQITVEP
>A0A151DUM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon SM1-50|TrEMBL
MDPDLQKILQRQHYAIIGKHSGVKLCHWVKQSLLFGRQCYKQTFYGINSHRCLQMTPAIT
HCTQMCLFCWRFQNFTEKELHDIDEPEYILNHAIEAQKTLLTGFKGDPRCDQKKWREANE
PNMLACSLSGEPTLYPRLGEFFELCHHKGITTFLVTNGTNPEAFEKLDTLPTQLFVSIVA
PTKEIYKKLCAPLISNGWEKIQQTLALLPSLNTRIVIRHTLVHGWNMDEKHVDAYARLDA
QASPLFIEPKGYVFVGSSRKRLHFSNMPRHDQIRDFGQKLAERLGYEQVMEKNDSLVVLL
SSKSTNNK
>A3AN61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza sativa subsp. japonica|TrEMBL
MPPPFPTATAAASTTSHLALLLLLSSSSVFFLYKSLRLRRNNPPSPPPGQGPAPTPTLLY
ASATGTSKALAAGLSRRLAEAGVTAHPADAAAFDPDDLPSLPLLLLVLPTHDGGAPPSAA
AFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAEVV
AVGEGDVDGGDLEVVFEEWCGRVVRVVKGEEIGEGTTERAMALMSWKRRNPMMTTTKRRS
MAGRSTWRTLPGRHRRQGGGMGRWRGLCPTEGRMGYKIIGSHSGVKICRWTKSQLRGRGG
CYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDDPLDIVNAAIDQH
TKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPEINVLIDELHRRHISTFLVTN
AQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLKSLHDKDQRTVYR
LTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKDFSEA
LALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELVTSGKPFRSQDYM
ALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A6P9BYI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pantherophis guttatus|TrEMBL
MDTPAETWDNLHAHLTFLWLNRFYLYSCAAFGISLWFCFQFLNKAKEQNKNRLAELNLPK
IPAAEKEQQDPSLGKVHVAGVKVFYGSQTGTAKRFALVLTEAVASINLPAEIIDMQDYDP
DDSLIDEISSQNICMFLVATYTDGKPTENAAWFCKWLEEAANDFRVGKAYLKGLRYAVFG
LGNSVYADHFNTVSRNVDKWLWMLGARRILSCARGDGNVVKSQHGSIEADFEVWKVKLLT
RLQALAKGEQKACSGKCKKGPCRSKSKVSQEAKEQETSNHVEKDEEDFFETTSEEESDIE
NGRGADQVVDVEDLGKVMGQMKKSQKEHQIDGEVPIGVGTQHSRKEDERREMITPALRDA
LTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILKEAIENHQNLIKQFKGVPGVRDDRFREGMEAKHCALS
LVGEPIMYPQINQFLKLLHHRNISSFLVTNAQFPEEIRNLQPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLQALAEKHQRTVYRLTLVKAWNVEELKAYSDLVSLGKPDFIEVK
GVTYCGESSASNLTMANVPWHEEVKRFVQELADLLPDYEIASEHEHSNCLLIAHKKFKIE
GKWHTWIDYDRFQELVHEYEQSGGIKTFTSADYVALTPPWAVFGAQERGFDPTDTRFQRK
NKTKDISGC
>A0A1E4S8S3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyberlindnera jadinii (strain ATCC 18201 / CBS 1600 / BCRC 20928 / JCM 3617 / NBRC 0987 / NRRL Y-1542)|TrEMBL
MPSAILVPLAVAIYYAAGGRLSIALAIGVIGYIVIYESKKLKGTTGQKTVTNSENEHNHE
HTHTHKHKHKEGGCGKLCTCKNKGLKPKKTLSALKNKKGFGQKKAANGSEKDMAVDFTST
FARPTKVSSADREEPAKKKRVPKIIKSKGATRGIPKTTWTKAPTSLLDSNIIIFYSSLTG
ASQRSSQYLYDNLCAIGDLKNKPQLLNLDEVADLDDYFIKTPDLENLVYCLVLPSYDVDS
PIDYFLETLEDTYQDFRIDKYPLKKLMGFTVLGLGDSESWPEKFCYQAKKTDYWLGKLGG
RRIFPVGEICMKTGGDLKVHEWISLFTDALKDDEPILYEYIDSDNEEDSDNSEASEKSQD
TLVDVEDMGKMMSSSKEPETTSETKQMVAKNSPTYKSLTKQGYTVVGSHSGVKICRWTKS
ALRGRGSCYKFAFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWQVDEPDVIL
EGALAGHYAKIKQMRGVPGVVAERFAEAFRVRHCALSLVGEPIFYPHINEFLSMLHEKEI
SSFLVCNAQHPDQLEKLTQVTQLYVSIDASTKSELKKVDRPLFRDYWERLMRCLDILRTT
QSHQRTVFRLTLVKGFNMGDVSGYADFVEKAAPALIEIKGATFCGSSAGNGNPLTMQNIP
FYEECQKFVVSLNEELNRRGLGYGIAAEHAHSCCILMASNQFKIDGEWHTHIDYPRYFEL
LRSGKPFDKLDYISKTPDWALWGSESAGFNPEDTRVRKKGKYKKLTT
>A0A662FWS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MVDSAITTIRRAYIKQKYHFVGRYAVVKPCHWVKKSLNTRGREHCYKQKFYGIPTHRCLQ
MSPTIFCNEECVFCWRAHPRELGVKIDETGEFKYDAPEDIVRNSLLEWRRILSGYGGNPN
VDRLMLEEALRPIHAAISLIGEPTLYPYLGELVKEFFKNGFKTVFIVTNGTRPEVLANLE
VYPSQLYVSVVGPNREVFEKTTRPLIPNAWDKLNETLEILSSFNIPTVMRLTLVKGLNMV
DIEGYAKLVLKAEPTYVEPKAAMDVGWFRRRLDRTNMPTHEDIRRFSEKLSELTGYRIID
ESIPSRIVLLSKLDRPIRLVPIEEATHLDYLREILRQGKSVLPEEH
>A0A7L4BH85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phaetusa simplex|TrEMBL
LNVSMDMWSFSYTCLVSLWLHRFYIYSVVAFGIGIWIIIQFFTTKTKKKGEKSNGNPAAS
EGTKDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFATGLAEAVTSLNLTVEVISMGD
YDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLGEAANDFRFGKTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSSKKQSKESSDHEHGASEHENTEAEELFETSSEE
EADAEEAGGTNAVVDVEDLGNIMSHMKKAKVLLLERMSHIAGLNLLICHPVMEKSCGHPL
LIYFLFPGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHC
ALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKES
LKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFV
EVK
>A0A662V489|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MLAKLRHQKYHLIGSHSAVKKCLWVHNALVHSRFCYKCKFYGIESHRCIQFSPSTLWCWN
ACLHCWRVRPQDVGFTYRDLIRLPYVDDPEFIAEMAILEHRRTVSGYRARVPEHLWREAM
DPKHVAISLIGEATLYPRLGELIEVFHRKGLTTFLVTRGIRPEVLASLDEEPTQLYVSLE
SWNKMMYDDFNRPLTSRGWERTLETLEILPSFTCPTVLRITVIKGFNMDHESLKGFAKLI
NIAEPTYVEVKAYMHVGKSIERLSRESMPSFNDVLEFSKKLAEEISYNLASYSIPSRVTL
LTKFKKSVIRYGKGCPKGWYEEEKGDEFSGEYGRVEEVI
>A0A395HZR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus homomorphus (strain CBS 101889)|TrEMBL
MAESSVADGLLAFWHLYRLPLLLALVAAFTFLRAYRTLQPRHKTATASSIPSSPRSQSPE
KNEKIAVAYDEEATKNGETNAKLIVEEETSPKATAGPKRVSGKKPLKVAGRRAGSDQETP
LSFIQPIIFYASLTGTTERYAQVLLEDLRAAAQERADPDNRERGILPPQIHDLSYVDFDD
YFATAPKPPSTSPGTRYVYCLLIPSYNIDTVLNTFLGHLDETHNDFRIDTAPLSSLAGYC
VFGFGDKEGWPTEEEGYCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAEAALKEWSHGL
QDILGDILANGGLGEGVPGSGDPLESDEEELDEEGSDGNNRKTNRKRNKAQDVVDLEDIK
FSADSQSGSGAPVPVDFTTAGTSSALAPQASEKEMVPKTSPTYAALTKQGYTIVGSHSGV
KICRWTKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWK
VDSPELIFNGIKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINSFL
SMLHSEHISSFLVCNAQHPDQLETLSRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQR
CLDILREKRHMQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAG
AGLTMQNVPFYEEIQEFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFYVNGKWHSR
IDYDRFFELLEKEKADGTPFKPEDYMKETLDWALWGNGGFDPNDERVYKKGKKKGLQAAA
SAQD
>A0A7K6LJA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Falcunculus frontatus|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVTEPGNPASSE
GTEDKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDY
DPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAV
FGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKF
LTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEEE
AGGTDSVIDVEDLGNIMGHMKQAKVLLGQTSHAFGRDRVCADKGQSATPAPVSTPALGSW
EKSFPSYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEVILQEAIEHHQNMIKQFKGVSGVKAARLEEALRVKHCAL
SLVGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLR
RIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLLAHSKFQV
DGEWRTWIDYGRFQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQR
KNKARDISGC
>A0A0V0SGA7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella nelsoni|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVFDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLNKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVCEVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDICERCVMIHFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLVG
THSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGT
EWKWKTDPAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPH
INELISKMHSLNISTFLVTNAQFPSAIKNLIPVTQLYLSVDAASKESLKEIDRPLFRDFW
QRLMNSIDILREKKQRTVYRLTLVNRYNMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKD
SKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYE
KFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A7L4QG08|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosa archaeon|TrEMBL
MEKVWSILKRQKYRIVGAHSAVKICHWTKQSLTEGRVCYKQRFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEDAPAKYDDPEEIIEGCIEAQRELLSGYHGFLEKVDINKLKEAEN
PTNVAISLAGEPTLYPDLSGLIEGFRKRNFSTFLVTNGTTPEVLSSMSAYPDNLYITLPA
STKDTYEHVCNPQISNGWEKLNESLELLPKIKTKRRILRLTLVKDFNMGDIGKYSKLIEK
ANPDFIEAKAYMYVGYSRKRLEVGNMPTFEDILEFCKKLEEESGYRAIDSASDSRVVLLS
RD
>A0A423WPN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Valsa sordida|TrEMBL
MELEPFEVSPWLAQLSDSGVEYWHTNRTAIILLALTVLLLVRIYLHLTEGKEPLHLLPKL
YDTEDKIAKVEEKFEEKIQEKVEVAARIKSNGPRRIKGDLAKRKDTEVQPGRRQIKTIVF
YTSLTGNTEKTVKEFVKTLAGLLDTVTTSSTCAFSNPEVLDLAELDLDEYFITPPKLEEQ
DDVRTEIFYLFLLPSYNIDSTNDTFLEHLKETHHDFRIDTAPLAPILGYSVFGFGDREGW
PTEESGYCFQAKELDKWMAKLTGRKRAYPLGMGDLKRDGTQRLGEWTTGLLDVLGQLARD
GTLGEGVVGSGDAVESDDEADVDDDDGEVVFEDDAQFKPSKAKSSGDLGDLEDIGRILQS
SKDDGNAKPAAPLAVDFTTSSKRKQPVQTVKEMVPKNSPTYNSLTKQGYSIVGSHSGVKI
CRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTNWRWVVD
PPDLIFNGVRENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGM
LHKERISSFLVCNAQHPDQLAALNHVTQLYVSIDASDKESLRKIDRPLHRDFWERFQRCL
EILREKRFKQRTVFRLTLVKGFNIDEEAKGYADLVEKALPCFVEVKGVTYCGTSTSSSAG
LTMANVPFYEEVCSFVTALNLELERRGLKYGIAAEHAHSCCILMGSERFKVDGKWRTLID
YDRFFDLLEERGPDGDFTPEDYMGEETPEWATWGNGGFDPRDQRVDRKGRPIER
>A0A147JSJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon DG-33-1|TrEMBL
MAISAHELVDLERSGYRFVGKNKHSAVKVCHWTRKSLLNRGFCYKQQFYDIRSHRCLQLT
PSLPFCDHKCLFCWRNIDVTYPSWIGEVDEPNDILDEAILAQRQLLSGFGGNPNVNRKKL
QEAQSPKHCAISLAGEPTIYPKISEFIEECHKREMTTFLVTNGLHPDRLAEISEPTQLYI
SVTAPDPKTYRTICQAQVNDGWGRLNRSLGLMPSFKCRKVIRLTLVEGLNLKDAPGYAKL
IERAECDFVEAKAYMHVGFARARLSLENMPSHAEIKDFAQELMRESGYEIADESEPSRVV
LLKK
>A0A420U6H6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella intermedia|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVGFEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTREEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIADDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A8C6NSL5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothobranchius furzeri|TrEMBL
MKNYDPDDRLADEVSEVPQRTELLFNQRDTGERLAAGLSPTEPGRAQPAEETWVPLPMGS
PLVGGAKGVRCSCLFLKVCPVFVFLLLPSAAIFNMISSQCVGRSVCVFLVATYTDGRPTE
NAEWFCKWLEEASTDFRYGKSYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKR
ILTRGEGDCNVVKSRHGNVQADFQAWKVNLLSRLQALAKGEKKSCSGKCKGGSSCKDKNE
EVTSQDVLMFQVDRIESSSEEDESGLADERTSGSVVDVEDLGNIMTSAKKSKAENDEGQM
VKMNGGKKTEDDGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKH
TFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAENILQESIEKHQNMI
RQFRGVPGVKAERYEEGLEVKHCALSLVGEPIMYPEINTFIRLLHRHRISSFLVTNAQFP
EEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLV
KAWNVEEMMAYAELITLGQPDFIEVKGVTYCGESAASSLTMANVPWHQEVVAFVQQLADM
LPRYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVVVHEESGGQRTFSASDYM
SRTPSWALFGAQEQGFDPADTRFQRRNKTKDVSGC
>A0A5N6F800|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus novoparasiticus|TrEMBL
MAELSLAEGLVTFWHSYRLPFLIAIASVAILLRAYRKFQTKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKPATGNDPAPKVVSGPKRVSGRKPLKVAGRRLEDQGPPL
SFIQPIIFYASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSQGLQ
DILIDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAALSQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKGLQAATE
>I3XS18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcus amylolyticus DSM 16532|TrEMBL
MTMNWDEVRKKREEFWSSSPVYKAIYDRLVKQGYHLIGTIGAVKRCHWSKEAVLRNRYCY
KCLWYGIESHRCIQMTPVVAWCWNRCLHCWRLQPEDIGMHWDDTRPPVIDDPEILVEESI
RAHREIMAGFKGNPRADQKLVEEALNPKHAAISLTGEPILYPRLGELISEYHKRGITTFL
VTHGTRPDTLRNLETEPSQLYISIESWDKDSYEHFNRPLVPRAWELFNETLELIPSFKSP
TVFRFTIVKGFNDHEIALKNFAKFVEKAQPSYIEVKAYMYIGGSRGRLFKNNMPSHIEIR
EIARKIAELTGYTVMSESVPSRIVLLSRVGKPKRHGRGCPDGVENPEKYVPVLTEEYEEI
QD
>A0A8H4Q6A3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps camponoti-floridani|TrEMBL
MEVPGWLPLYGAIDGPRLALADVIDLWHAYRTSLILCVVAILFAFRLFLRSHEEETLLAL
PSVYRHGEHAPVEKTSSGPRRIKGRAVKKAKRPVDDAASTIPPVKLIVFYSSVTDTTAKL
ARVYHHGLFSVVERLARETGRSFLKPELLDLAEMDLDDFFVAPPTTPAEAGLFYLFLFPS
YNIDSINDTVLQHLRETHHDFRIDTAPLASLLGYSIFGYGDREGWPDEERGFCFQAIELD
KCMSKLTGRKRAYPVGMGDVKGDHEERFAEWAAGVEDVVANVARTGHLGLGVRGSGDAVE
SDDEEVDGGDGGGGGGEDASDQRRERPLDDVEDLGKLLRTSGANSGANSGANSGANSGAN
SGANSGAKPPLAVDFTTYSQQQTPAVVKEMVPRDSPTYAALTKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDAPD
VIFRGVKEGHYSKIRMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHA
EGISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRKIDRPLHRDFWERFLRCLDIL
REKRFRHRTVFRLTLVKGFNVADEVEGYARLVERGLPCFIEVKGVTYCGTSTSANAGISM
SNVPFYWEVCDFVRALDARLADMGLAYGIAAEHAHSCCVLLASERFRVDGLWRTHIDYRR
FFQLLGQRGADGDWSPEDYMGDPTPEWALWGNGGFDPRDTRVDRKGRSMDVTVVRHRPPE
MEHMS
>A0A509AQV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium berghei (strain Anka)|TrEMBL
MIKKREDELVLPHNEVGNINIYSIQKKAKINFTLIYGSESITSYKEGKEFLNELIVFFND
ILNHFNIISTITKGDEKNDTIFEKSINNEINNIEAYMFEYFRSKLLKTKKKNKDGNSEKK
CKNEKADNESPKCNNEVKDIFDNLKKYEKNIIKCGNTHFNNYLNCSIENNISEINFDFVN
GNEFDNYTFFENSENNDLNILFMFISTYNFGAFPANCYKLEDALTDLVNDFRIEKNYLKN
IFYSCVGFGNKEYGNAYFCTPIKKCDKFLSSLGANKLEKTLKLCSTMDNEKEIIQWKSNL
LTKICLSLFLYNFNYTKFSNNFFHYSNRKNYNTLKYYCTYFCKKKEDVKSMAINNDRENK
QTTKSSGNNNINKCECISNDMSLKYLDTPKEPNNDQNKLINNINGHISFFTSNTDVNSTE
KCGCTSNNCSNGNDKYINKKKIINNNFETPIINECCKKEYDKNIENDELINSDFNSESMS
ENIDEINCNSSEELEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQLRG
RGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPIGTKWRWNKDEANFIVDEAV
KKHKNMIKELKGVQCVINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFL
VTNAQFPNELKKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKGKKERT
VFRFTLVKEYNMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVY
QFAFHLINSKRYISDIYEISCEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVKQNAN
FTAIDYCEETPEWAVIGAPECGFNPSDQRVYTKGKNKNKKNINTMEVKT
>A0A7C5K1K9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MVDSKLRRALEKQNYALVGKHSAVKICTWTKKALRDEDVCYKQKFYGIRSHLCCQMTPSV
DYCPNHCLFCWRAIELTPGSEIPAEEADEPQDIIDGSIKAQRKLLSGFPGNPKANPKKVR
DAMEPMHFAISLAGEPASYPKLDELIGLLHMRGKTTFLVTNGQFPETLSKLKNLPTQLYL
SLTAPDEATYLRTAAPSFRDAWARLNRSLEIMAGLRDKTRTTIRMTLVKGLNMHSPEKYA
ELIKKANPLFVEAKAYMYVGFSRDRLSMENMPSHSEIREFAEQVGSRCGYKIVDEKENSR
VVLLMQKDFPGRIMKFD
>A0A7J2NEV0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MQDKAQVRKTLKKQQYGFSGGHTAVKICTWTKRSLLNRDVCYKQVFYGIQAHLCCQMSPS
VNYCQNSCIFCWRSFADTKGFDEIPRDLADKPEAIIEKSFSQQRKLLSGFGGNEKVSLEK
LKQAQNPKHFAISLTGEPTLYPFLPELIEALHKRGITTFVVTNGLNPGMLKKIFPTQLYQ
SVSAPDEKTFLEIEKPKIKSAWNLFNESLGVMSEKRNSKTRTCLRITLIKGINDFAPERY
AQLIKSANPLFVEVKSYMHVGSSIYRLEKTNMPLHNDIKEFAGKISAFCEWKPADEKKES
RVVLLMKPEDHGKRFLKDFSNISV
>A0A2R6D8V3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QH_7_65_31|TrEMBL
MSDSGPKQVDDPEYHSRNHTAAQTCGWTASALRGEGRCYKNRFYGIQSHRCIQMTPVVKC
NERCVFCWRDHTGHAYELDEVEWDDPEAVVDASIDLQRTLLSGFGGNDQVPSGMFEEAME
PRHVAISLDGEPTLYPYLPELIEAFHDRGITTFLVSNGTRPEVLRACDPTQLYVSVDAAD
RHTFDETVAATEDDAWERLLNTLDVLAEKEETRTVIRTTLVDGFNMHTPEWYAVMCERAD
IDFLEMKAYMYVGHSRSRLGHEHMPSHDEVRAFTERVGSFLPDHDTLREVADSRVTLLAR
DEDTWVPKLKGDSEFWA
>W4GWK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAKPVAVRILYGTHTGTAKGFATTLQQKLFALNVAGYAFEPSVVDMKD
YDQDNLEHEHVLISILSTWTGGVPPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLG
NSEYDEHYGKASKALSKHLSSLGASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGA
LRSPAASSSSSPSVKPKQQPAGWKSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIV
LELDQGDDSDDEDNRPKKPDSGVVDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYK
IIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNP
VGREWRWKTDDAKELVEGAISRHQTMIKEVKGLPGLIQSRWEEAFTVRHCALSLVGEPIM
YPHINEFCRELHAREISSFLVTNAQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFK
DFWERFLSCLTQLKAKGQRTVYRMTLVKEHNMKELDNYVELIHLGEPDLIEIKAVTYCGK
SDASDLTMQNVPYHQEVRDFCELLCAKLGGGYELATEHAHSNCVLVAKTKFKIDGHWHTW
IDYDKFHTLIQAYYKDGTPFTTMDYIAPTPAWAVYNAPEAGFDPIETRFRRTKEGKVVEI
EYTATDSGCG
>A0A8D0AFP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sander lucioperca|TrEMBL
MLISQKYGCTQHQLQRTVYFNTPIANMLSFFVIIVLCINRVSTLDTKVSQNAHSPSESYL
MSIWQNRLYLYSAAALVFGIWFSLKLVLKKKSFSKDVGPWVYKAVKSNDIPDRDTSVHVS
GVKIFYGSQTGTAKGFAEELSEEVKTLGIPAEVIDIKDYDPDDQLADECTNKSVCVFLVA
TYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDK
WLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFVSWKVRFLKRLQALAKGEKKSCSGNCKT
GGLCKSKRKDGQEEEEEKEEEKEEKAALQNNSSEEDLIESSSDEEDSGLQDEKNSGSVVD
MEDLGKIMNSAKKAKSKEEGRGDGQMVKLSKLNGVKKIEDDVERREMITPALRGALTKQG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHT
NPVGTEWRWKMDPAEKILQDALEKHQSMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEP
IMYPEINTFIRLLHSHRISSFLVTNAQFPKEIRSLVPVTQLYVSVDASTKDSLKKIDRPL
FKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVTYC
GESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLMAHTKFKVDGEWWT
WIDYERFQELVQAHEESGGQQGFSALDYMAKTPSWALFGASEQGFDPADTRFQRRNKTKD
ISGC
>A0A418BKY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aphanomyces astaci|TrEMBL
MLVFKPATVAVAVAVVSASIAYVLWKQRQQEQGTSPKQSARKESSGCCGKDSATTTGCCQ
SSTNDDNVEAEEHAEPVAVRILYGTHTGTAKGTALSHVVDDNLEHEHVLISILSTWTGGV
PPESALVFCNWLQDMAQDFRVSKTWLKHVHVGVYGLGNSEYDEHYGKASKALSKHLSSLG
ASRLCPRGVGDDNQDQAAQFDSWSDHLIAALCEQYGALRSPAASSSSSPSVKPKQQPAGW
KSQNEFRRQKRKEKAAANGEDTEEAMWTAEDQMNEIVLELDQGDDSDDEDNRPKKQDSGV
VDVEDIGVVMKESEAAALSREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGG
CYKHTFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDDAKELVEGAISRH
QTMIKEVKGLPGLIQSRWEKAFTVRHCALTLVGEPIMYPHINEFCRELHAREISSFLVTN
AQFPEKIAALEPITQLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLNQLKVFERAL
>A0A2H5NSG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Citrus unshiu|TrEMBL
ISYCRLWGVREMAIARFARLGRHAKRPHGLCVKMTAVAILGLCFIFAWSTFSSSANSVTT
QRESFDDIAEPVSADTKVISSKPQYTERKRQWHEIGKEEDKKVKLESDLDKAKEKKINGS
ASVTVIKHESRKKNEKTVPNVKKQKHTVKSVNEETNEENEKSESDDSLKEDEEEQEQEVV
DGKEEESVSESEVNGETEGDVDLVQQENEQSVVTVEGESGRSRSTGKKRKVKGPVFDPKA
HYSWKLCSTRSKHNYIPCIDNESGFGKFQSYRHTERSCPRSPLMCLVPLPHAGYGSPVSW
PDSKLKILYKNVAHPKLAAYIKKHNWLVESGEYLTFPQNQSEFKGGVLHYLESIEEMVPD
IEWGKNIHVVLEIGSADSSFVASLLDKEVLTLTVGLKDDLVDLAQVALERGFPAVVSPLG
NRRLPFPSGVFDAIHCDGCSITWHAHGGKLLLEMNRILRPSGYFILSTKHDSIEEEEALT
TLTASICWNILAHKTDEISEMGVKIYQKPESNDIYELRRKKNPPLCKENENPDAAWYVPM
KTCLHTIPSSIEQHGTEWPEEWPKRLETYPDWLNDKEKLSSDTRHWKAIVDRSYLTGLGI
DWSKIRNVMDMKSIYGGFAAALAQQKIWVMNVVPVHAPDTLPVIYDRGLVGIYHDWCESF
GTYPRSYDLLHADHLFSRLKSRCRQPVSIVVEMDRILRPGGWAIVRDKVEILDPLEGILR
SLHWEIRMTYAQDKEATTFYFAYKSRRLNKFLRHSDYRKKPENPNPNKGKLFFISQTGTS
KTLAKRLHALLTSNDLLFDLVDPQTYEPEDLSKEALVLIVASSWEDGKPPEAAKFFMNWI
DESANDFRVGSLLLSNCKFAVFGVGSKSYEKTFNMVAKDLSKKMRELGAGEVLPVVEGDV
DGGELDVVFEDWSKRVVAILKSGGDRLENGIVNGEASIVGVESDPVYHEYDDDEEEEDVV
ESEMVDLEDIAGKGPSRRSVNVAETNGKVKDGKRDMVTPVIRASLEKQGYKIIGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKM
DDPIEIVNTAIDLHTKMIKQMKGVPGEYSIFVLLDFFYFGTVSSAIDKQIPPSDGEEKES
SVTLERLNEGLTPRHCALSLVGEPIMYPEINTLVDELHRRRISTFLVTNAQFPDKIKLLK
PVTQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLKALRDKQQRTVYRLTLVKGWNTED
IEAYSKLFSIGNPDFVEIKGVTYCGSSATSKLTMENVPWHADVKAFSEALALRSEGEYEV
ACEHVHSCCVLLAKTERFKVNGQWFTWIDYEKFHDLVASGRPFSSKDYMAASPHWAVYGA
EEGGFDPDQSRYRKERHHKSISIAHCNTIKQFSTHGSICVKLKIVLTGEQILRFFISILS
MKDVCRVCSVRSDPYPK
>A0A7L0ZDW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oxyruncus cristatus|TrEMBL
LDVSMDTWSYFPTCLASIWLHRFYIYSAVALGISLWIVIQFTTTKTKRKVTERTEDKLVN
GCAAPQAKEVYVAGVKIFYGSQTGTAKRFAKALAEAVNSLSLPVEVISMGDYDPDDCLAE
ETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRVGKTYLKGLRYAVFGLGNSVY
VDHYNTVGRRVDRWLWMLSASRVMTRAEGDCNVARSRHGSIEGDFEAWKAKFLTRLQALC
RGEKKPCSGKCKKGKCTSPGKQSKESSDHEHGASEHENTEAEELFETSSEEEADAEEAGG
TNSVIDVEDLGNIVGHMKKAKVLLLLWVGNGGEALAQVAQRSCGCPSPASVQAGLEQPGL
VEGVPARGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPELILQEAIENHQNMIKQFRGVSGVKAARFEEALTVKHC
ALSLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTRES
LRRIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLGKPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVGFVQDLAELLPDYEIACEHEHSNCLLLAHTKV
SL
>A0A7L0V2A6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leptocoma aspasia|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRSYIYSAVAFGISLWIVIQFTTTRTKSKVTEPKSHGNPS
SREGTADKLQNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVASLNLPVEVINM
GDYDPEDGLAEETCSGNICVFLVATYTEGQPPESAAWFCKWLEESANDFRVGKSFLQGLR
YAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWK
AKFLTRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSS
EEEAGGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNVHGVNHSGYHLVYFVCQFLQAKVS
CLMICALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACAN
KCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKAARLEEALAVK
HCALSLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRQELQEIPPKLPPETLEL
EPVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVD
ELKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGI
ACEHEHSNCLLLAHSKFQVDGEWRTWIDYGRFQELVREHEQSGGSRTFTAAEYTARTPPW
ALFGARERGFDPLDVRFQRKSKARDVSGC
>A0A162FIR4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter oralis|TrEMBL
MSLTKEQQKKLEKSGYRFVGNNGHAATKICHWTKQSILDKGVCYKEQFYGVKSHRCLQMS
PAVPHCQQECEFCWRDLSYTNTDWDGNYDDPKTIIDGAINAQNNLLCGFFGNDKANREKL
AESKTPTNAAISLAGEPTLYPEIDELIAEFNRRNFTTFLVSNGQNVDKLKNLSEDPYQLY
LSLDAPTRKTYNEVCRPQIMNGWENLNESLETLASFNTRTCIRTTCVKGRNMINPELYAK
LIKKANPKFVEIKAYMCVGYSRERLTLGNMPTFDEVVDFACQIGDECGREITNESEISRV
VLLE
>A0A1X0NJY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma theileri|TrEMBL
MMIVNFLSDVFWWVFILLLIPAATLLLGKWLDAYFHTQRKAKLSAASQQEEKNGKEEKKN
GNIPIIPSSSSSSCCCNTTTTTTTTTTTRKGEVKKILIAYATQSNTACKLAHKLFSTMTA
ALYEAANSVDGMDSCCANNNNNNNNNNKDNNNNNKRSDCCRDRVREVPEVKVLQLAEDAH
QCSVEHLLESNAYGLVVLIASTHTNGTAPEASQSFAEMLLDAYNDFRVSRDVFAKTKFAV
FGLGDIAYGETYFNRFAKNLYTWCKGLGATFVVPPVYASEANMVNLFNVFSAALMKWMGR
VQFTEEGVVVITRKKQQLLLQRQQKKLNKNNKNNNNKGEEEEEEENGIPRVNAERDSEDD
EEDENDEENNNNNNDSAEEDDDMENLVMDDMDENNNNNNNNNNNNNNDPPELLYPRLRAN
LQKQGYHLIGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIASHQCMEMTPSLACANKCVFC
WRHHTNPVGRSFRWRVDPPQLLINEAVNGHQRMLRQMRGVPGVTAERLEEAMQVRHCALS
LVGEPIMYPAINEFVDLLHEKHISSFMVTNAQFPEQLRDLKPVTQLYLSIDAPTPEELKR
VDRPLFEDYWERCLNCVRELRRKPQRTVFRLTLVNKYNTENVAAYADLVRLGWPDFIEVK
GVTYCGTSSTSTLTMKENVPRHAEVVEFCEALCAALENCTPPRDKTVWMPTGNEEVVSSS
NNNNNNNNNNNNSDNEEKEDDTTITTTITSTGPYAIACEHEHSCCVLIALRRFCVNGVWH
TWIDYDKFMQLAQSGRKDFTSAEYAAPTPAWAVFRSHEKGFDPQQERVRRKGGKPVIVTS
GC
>A0A5N5HCR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrus ussuriensis x Pyrus communis|TrEMBL
MSLSSTPARLTLLALLSATTVYCFYKSRRLRRLKLSLNPNPGSSPRRGKLFFVSQTGTSE
ALARRLLDFLKLKGVAFDLVDPNNYEPEDLPKETLVLIVASTWDDGKPPPNAKFFSDWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDLARRMRALGASEMFPIWEGDVD
GGDLDEVFDAWSGKVVRFLKGGAAENGGVLGNGVSDECEAESFDVSDEEDEEEEDGGESG
VVDLEDIAGKGPSRRNPVAATKTNGTVNGKKEMVTPVIRASLTKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
LEIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALIDELH
RRRISTFLVTNAQFPEKIKMLNPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLTS
LKDKQQRTVYRLTLVKGWNTEDIDAYYNIFSLGSPDFVEIKGVTYCGTSATSKLTMENVP
WHADVKAFSEALALKSNREYEVACEHVHSCCVLLAKTSKFKIDGQWFTWIDYEKFHDLVA
SGKHFDSKDYMAPTPSWAVYGAEEGGFDPYQSRYKKERHHRTNQ
>A0A0V1PAY3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella sp. T8|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKKEKDKHREE
VKIFFASQSGNAQKLAYSLHSRLKSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDG
QCPEKCRWFFKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYGSTFNKVAIKLSKHLLLL
KANNILPLYLTEEDNFDHIQSDFLKWSLQLIKYLEVREVSKFSSLHDNKRVSVWHDENEN
SSDAEDAENSANNVGDIEDICERCVVMIHFTNVTNDSNKIKEMLTPTLRKSLTKQGYHLV
GTHSGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVG
TEWKWKTDPAEKILSDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYP
HINELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDF
WQRLMNSIDILREKKQRTVYRLTLVNRYNMNEVSQYAALINRGQPDFVEVKGVTYCGDSK
DSKITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDY
EKFFSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKGS
>A0A2Z2NCK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus radiotolerans|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPSQLYVSLTAPDVETYNRVNVPMIPDGWDRIKTFLEMMNGLPTRTVVRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGYSRNRLTINNMPRHEEIKAFAEELVKNLPGY
HIEDEYEPSRVVLIMRDDVDPRGSGREGRFIKH
>A0A662XX02|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothophytophthora sp. Chile5|TrEMBL
MAETLEKTLFALNIAGFHFQTSVVSMKDYDQDNLEHEAIVVAVLSTWTHGVPPEDARVFC
NWIADMTQDFRVSKSWLAGVPHAVFGLGNAEYDEDYGTAAKNLDRDFAELGSPALVALGL
GDDNVDQFQQFDVWMDNVVAAMCEYSSERAVAASGKAGDGSETEQASKKAWLSQKEFRRQ
KKAKKAQQDAASGVAVELNEEDLMNEQFLTDAFSDDEEEQIGQEANDDSGMVDVEDLGKS
MKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHAFYGI
TSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIERHQSMIKELKG
LPGLIPQRWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHERHISSFLVTNAQFPEKIAA
LDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKRKGQRTVYRLTLVKSYNM
EELDNYAELIDIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFCSALCDRVSGDY
ALASEHAHSNCVLLAKKKFCRDGVWHTWIDYDRFHQLVAKFYEDGSPFTADDYTAPTPAW
ALYDSKEQGFDPVETRFRRTKDGKVVEFEYQATESGCG
>E9AKI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania mexicana (strain MHOM/GT/2001/U1103)|TrEMBL
MIAFLLQLFTSLGLPLVAFLLYSHLADSVHTRGNVAQGDAGAVDGTDTFSRQVRAELEQL
DVASAPPSAAVAVPPAPVPAEILITYATQSKNSLALAHKLFSLITAHLHTAPLATAEDVV
RPLVRVMEMREEEGNSRNVCRVDTLLEQNQYALTIFIASTYTDGVAPPRSQAFEAMLKDA
FEDHRIPRNTLGRKHFAVFGLGDIAYGEEKFNAFAKNLHEWCRGLGAPPFVVPPVYATEA
KTQSLFRIFSTALLKWMSRAFFHADGTVTVKKKSEMAAASPAAASATEARSCKGGNTPII
SAGAEGERCACRQSSQPLCGSSAGGDGDDGSACCKAGTMADGVAASKSDDDDDDDNNNAG
NDDMDDVEDLVWDGTDDADFDLNKDPSELPELLYPKLRQNLEKQGYRLVGSHSGVKLCRW
TKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACANKCVFCWRHHTNPISRHFRWKQDPPE
LLIAQGMAGHYQMIKQMRGVPGVTPERLATAMQIRHCALSLVGEPIMYPQINGFCDLLHQ
HRISSFMVTNAQFPEQLRDLKPVVQLYLSIDAPTPEELKRIDRPLFEDYWDRCLSCVKEL
ARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQPDFIEVKGVTYCGTSSSSTLNMKDNVP
RHDEVVNFCKALCAEMASRHPHYRTPQMDREEAGGSDVIVIPAEERNRPYHVACEHEHSC
CVLIALDKFFFDGHWHTWIDYERFYDLVESGRTDFTSLDYAAVTPPWATYNSKEKGFDPE
QTRVVRKNARPTTVMASC
>A0A6A7G624|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hirondellea gigas|TrEMBL
RRESFYRRDAMGSTTSKDIPKISRHELASAEGICCAIDGKVYDLTRFASLHPGGEEVLRE
VSGTDASEEFEAAFHSENAISLMDQYCIGELVDTAEVPSPVGDSSCSDALPDPSVSSASV
EPITKECCSEEPNSQQIHVKVLYGSQTGTARNFAKSLALQIGGRFEGKIRSSTAIAMDDI
DPEDLSSESLIIILLSTYSEGNPAKNAEFFSNWIRDAVSDWRVDNSFLRKLRFAIFGLGN
SLYSDHYNEASRNLYQWLRKLSAHPLLPPYDGDNSIERSDSGSLETDFQSFGESLLSQIE
LAINDPSYFPDDVEVPEVKEFEDVPENLQYEDLGDEDEQKVQDQESSLVDLEELGSVMKE
QKKHKEQLVEEKKKEILREMVTPALRRNLTKQGYRIIGSHSGVKMCRWTKAMLRGRGGCY
KHTFYGISSYQCMEMTPSLACANKCVFCWRHHTNPVGREWRWVMDPPEFLLEEATKNHRQ
LIKQMKGVPGVLPERFKEAMTIKHCALSLVGEPIMYPKIQEFLDLLHSQQISSFLVTNAQ
FPGQIRKIKKVTQLYVSIDASTRESLKAIDRPLFKDFWERFLDSLSALKQKNQRTVYRLT
LVKAMNMDEVANYARLVARGQPSFIEIKGVTFCGSSNASNLTMENVPFHIEVRNFAQKLC
EYLLDEYELACEHVHSCCIVIARKEFKIDGVWHTWINYDKFHQLLKSGAEFGPLDYVSRT
PDWAVFGAKEEGFNPTDTRFVKKRKPPSERANLARLKAEKSVEESQRKTSGDKTLVYNDA
KRDLEALSISNDLASNKIAR
>A0A550D2V1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. F3|TrEMBL
MLAMQSNIRIDTLSEIYKELKKEKYHIVGTHSAYKKCHWTHESLVTNRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDDTKMPAYDDPEYIVERSIEEHKRAVSG
YFGREGVKLEKVKDAMKPAHVAISLTGEPTLYEKLGELIREYHKRGLTTFLVTSGIRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLLMKTLEILPSFSSPTVIRLTMIK
GYNMSDEDAKEFAKLFQIAMPTYIEVKAYMHVGPSTYRLSKDAMPRHNEIREFAKLLSNY
TGYKILSEHVPSRIVLLSKLDEPIKIGNAWNERWDWRTVDIEDDINGEYKEAELGCTEGS
T
>F0LLG4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus barophilus (strain DSM 11836 / MP)|TrEMBL
MENVKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKHNRVCYKQKFYGIHSHRCL
QMTPVLAWCTHNCVFCWRPMEGFLGTELPKPWDDPAFIVEESIKAQRKLLSGFGGIKDRI
NVKKYEEAQEPKHAAISLSGEPTLYPYIGDLVEEFHKRGFTTFIVTNGTVPEAIEQMKKE
GKLPTQLYVSLTAPDIETYNRVNIPMIPDGWERIIKTLELMRDLPTRTVIRLTLVKGENM
HNPKGYAELIMKAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEELVKYLPGYHI
EDEYQPSRVVLIMRDDISKEERFIKH
>A0A8I6AB63|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rattus norvegicus|TrEMBL
MGPPLDVWDFSSPLLSLWMNRFYIYMGCALGVTLWFCVQIIIKKQVTRSQEKSVPGAPDS
SLSPQEKHTHVSGVKIFYGSQTGTAKGFAVVLAKAVTSLDLPVAIINLKEYDPDDNLIGE
ITSKNVCAFLVATYTDGRPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYR
SHFNKVSTNVDKWLWMLGAQRVLTRGEGDCNAVQSKHGSIEADFTAWKTKFISRLQALQR
GEKKGCGGDCKRGKCESAQHGPGEVRSHPHGELHPGDAEEEEPCESSSEDEHGTKGYQSL
NSVVDVEDLGNIMNPVKREKREKAQPEEKVVVHRNSEKNEDSEARAMITPALREALTKQG
YQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPELILKEAIENHRNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEP
IMYPEINRLLKLLHQHGISTFLVTNAQFPEEIRNLTPVTQLYVSVDASTKDSLKKIDRPL
FKDFWQRFLDSLQALSAKGVTYCGESAASSLTMANVPWHEEVVRFVRELVDLLPDYEIAC
EHEHSNCLLIGHKKFKIGGEWWTWIDYSRFQELVLQYEESGGSKTFSSKDYMARTPQWAL
FGARERGFDPKDTRYQRKNKTKDISGC
>A0A7J2M9D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MSSDIRKLLEDQRYALVGEHSAVKLCHWLRKSLLEDKPCYKHTFYGIESHRCLQMTPAVF
HCTQKCLYCWRYQGFTLTEMSGTVDEPSDILQQCLDAQYRLLTGYKGDERVSSKKWREAI
EPKHVACSLTGEPTLYPFLSDFFEECHKRGMTTFLVTNGTVPEALEKMDTLPTQLYVTVA
APNEDIYKKICCPLIPHAWEKLNATLELMPSLDTRTVIRHTLVKGWNLGYETEYAKLDEK
AHPWFIEPKGYMFLGYSRQRMTMEHMPSHEEIRAFAERMASVTGYTIESERRDSRVVLLG
RGKERFIT
>A0A8D2E830|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theropithecus gelada|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKMQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKPGLFRNMGRNEDGERRAMITTAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFNDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A091ERU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Corvus brachyrhynchos|TrEMBL
LGVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVVQFTTTRTKRKKSHGNPASSEG
TADKLGNGCALPQPQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHENTEAEELFETSSEEEA
GGTDSVVDVEDLGNIMGHMKKAKVLLLEGVWNGAAGTGRKEEAERREMITPALREALTKQ
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHH
TNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALTVKHCALSLVGE
PIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRP
LFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLITLGKPDFIEVKGVTY
CGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKVRLP
>A0A6A9SDZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium sp. CBA1126|TrEMBL
MPKQVDDPDYHHDNHTAAQTCGWTANSLRGEGTCYKHAFYGIRSHRCIQMTPVVRCNERC
VFCWRDHAGHTYELDGVEWDDPEAVVDASIELQKKLLSGFGGNDDVPRERFEEAMNPRHV
AISLDGEPTLYPYLPELLEEFHDRGLTTFLVSNGTRPEVLEECDPTQLYVSVDAPERATF
DDVVGATEDDAWEKLVDTMDVLREKKATRTVLRTTLVGGENMQNPDWYAGFYDRADPDFV
ELKAYMHVGDSRDRLDREAMPSHEDVVEFAEAVQEHMPEHTVLRDQEVSRVALLAREEDT
WVPKLEADSEFWAGSTAD
>F2EH66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hordeum vulgare subsp. vulgare|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSITLRRLRRSPRPSPSPSSSPPAAATAP
TLLYASTTGTSKALAARLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAP
PPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGA
VEVLPVGEGDVDEGDLDHVFEEWCGRVLRVVKGEEVEEEDGVNGEANGFDGMEGEESDYD
DFDDEDEEEEEVASGEVDMEDIAGKATAKKQNGKVEGALPNGGQNGARAMVTPIIRASLE
KQGYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLV
GEPIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVD
RPLFSDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEVKGV
TYCGSSATSKLTMENVPWHADVKEFSEVLATKSGGVYELACEHVHSCCVLLAKVDKFKIN
GKWHTWIDYDRFNELVMSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAA
ALKG
>A0A7J4RLV1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thalassarchaeaceae archaeon|TrEMBL
MEPRIAAKLSKQKYQLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLESVKAHRRLLTGFGGNPKADKEKFLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHNHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQGAFHKLEETLELLPSLDTRTVCRHTLIKHESLGFHEDYARLDNLA
DPDFIEAKGYVNVGNSRNNLSVENMPTHQEIIEFSEKLAPLVGRKLLSDRRESRVALIGK
KMIPVDLPIASMDLPKDLGIAKPQRFMLPQV
>A0A8J8DCU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. M39|TrEMBL
MENVKPNMPEEIARLFKKQHYALVGRHSGVKLCHWLKESIKHNRVCYKQKFYGIHSHRCL
QMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQKKLLSGYWGVKDQI
NVKKLEEAMEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEELIKD
DKLPTQLYVSLTAPDIETYNRVNIPMIPDGWERIIKTLELMRDLPTRTVIRLTLVKDENM
HNPKGYAELIMKAKPMFVEAKAYMFVGFSRNRLTINNMPKHEEIKAFAEELVKYLPGYHI
EDEYQPSRVVLIMRDDISKEERFIKH
>A0A0V1PZG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Debaryomyces fabryi|TrEMBL
MSLGNTVLALCCILYLLSGGRWSIVLAVGTLSFLYTKNKQTTQVITKSISEEKTVKEQNN
KPSPIYAVDFTSTSFTPDATTRIPENKLRSIKPVSSLRPRGRRSPKIIKASKPITNTSEP
TLTRSAVNLLDSQIYIFYTTLTGSSQRVAKALYEKLEHLPNLTNKPKLLSLDDDVDDLEE
YFLKTPNAEKDKSIYLLVLPSYETDSPIDYFLEHLKETYQDFRVDKYPMRSLLGFAVLGL
GDSESWAGEKFCYQAKLADRWMGKLGGRRLYPVGEVCMKYDGEPKTNTWIQSFASLLADD
EPFYLDANEEIDDSDYENDSDGEDANTLVDVEDMGDIIKKQGTKGLSSQTEVKQMVAKDS
PTFKSLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSN
KCVFCWRHGTNPVAKLNWRWELDPPEKVMEGALQGHYQKIKQMRGVPGIQMDRFEEAFKV
KHCALSLVGEPIFYPYINEFVGMLHEQHISSFLVCNAQHPDQLAKLNRVTQLYVSIDAPT
KTDLKKVDRPLNSDFWDRLMSCLDILRTTQSHQRTVFRLTLVKGFNMNDISSYADMVIRA
QPSQIEIKGATFCGSSNSNGNPLTMQNIPFYEECKQFVISLSEDLKSRGYDYEIAAEHAH
SCCILMAHKRFFRNGKWHTHIDYPKFFELLESGEEFNDIDYIRETPDWAVWGSEEAGFNP
VDTKFDRKAEKMKNRLEREEKAKKVLEQQKIH
>A0A2D3VI54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ramularia collo-cygni|TrEMBL
MNFLDLPSELLFLWHAHRTEFLVAAGVFIALIRLTAHWRSTRSKVVLTPRSSTPTTEKPD
PISIPAVKDTPARIAVKKVPRRVKGVKNLKQTSQVQETTPISAIQPYVFYFTLGGSTKSH
AERLASTFPTSDSRILPPQLHDLAEIDHDDFXISPPATQDAETAAFYMILLPSYNIDTEL
ANFLGHLDETHHDFRIDTAPLRGLAGYAVFGFGDLEEWPSEEEGFCSQAVEVDRWMAKLT
GRKRAFPLGMGDVKDKVGMEVQLEGWRRGVLSVMNDLSEGKGLGEGVRGSGDAVESEDEG
EEAQDGDEETLISKPQDLEDIRPPIPVDFTTTSTKTSTSHITNIPKEMVPINSPTHTSLT
KQGYSIIGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHRCMEATPSLSCSNKCIFCWR
HGTNPVGTTWRWQVDPPDMIFKGMLEAHVKKIKMLRGVPGVRAERFQEGMEVRHCALSLV
GEPIFYPHINELLGMLHAQHISSFLVCNAQHPDQLASLGPVTQLYVSIDASNKESLRRID
RPLHRDFWERFQKCMEILREKRDTHRTVFRLTLVKGFNIEEEVSGYADLVEKALPSFIEV
KGVTYCGTTTAAGAGLSMQNVPFYEEVQGFVLALEKELGRRGLEYGIGAEHAHSCCVLLA
DRGRFFKEGRWHTLIDYEKFFQLVESGKAFGPEDYVGGPTAEWAAWGKGGFDPRDERVDR
KGKPKEVQAANYPDLVDGKRVVEI
>A0A151FBV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theionarchaea archaeon DG-70|TrEMBL
MDEELKSLLKRQRYRIVGNHSAVKLCHWLRKSLLEDRFCYKQKFYRIKSHRCLQMTPAVT
ACTQKCLFCWRPTQFTEPELTEHDDAAFIVEESLKAQKVLLTGYFGLPERVSAVKLKEAL
TPTNVAISLAGEPTLYPELSELIRIYKKKGMTTFLVTNGTNPEVLETLELPWNLYLTLAA
PTEAVYKKLCHPQTKGWESLIKTVNLFSTLDTQRVIRLTLVKGYNLIHPEVYSQLIEKAS
PDFVEAKAYMYVGYSRYRMTIDNMPSYDEIEDFARKIEHFSSYEIADSQKASRVVLLKRT
>A0A0F8DUM3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 2.H.T.1A.8|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFYIPDFATLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPSMLAKINPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDFMK
EKSSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISYLD
>F0UN90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces capsulatus (strain H88)|TrEMBL
MAGDVLQIFAQRLLTSWHRYRIPIFFLAAVVSIVIWLSTRYHKRNTPLSDSLSPCQSEKQ
NRNDKAEPCRVESPSNNDPAAAFYPNSDHSGSSIESQVRQAKQSANGPKRVHGSKPVKKG
ANNRTNPGELSRDINIQPMVFYVSLTGSTEAYAKSFCHRLQKATHALIENHSKTAILTPQ
LHDLSYIELDDYFITAPKPPDSSPNTRFFYCILIPTYNIDTMINTFLGHLDDTHNDFRID
TSSLSGLAGYSVFGFGDREGWPSEEEGFCSQARDVDRWMAKLTGKKRAYPLGMADVKGDN
TQMVLNDWCDGLSGIMFDLISSGGLGEGFPGSGDPIESDEEDIRDDEENDENGQSLRNKR
KEEQIVDLEDIKFGVTDGKGTSTDRQLLPIDFTTHSHPQASKPVSQPQLEMVPTSSPTFT
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWKVDPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINEFLALLHNEHISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLR
KIDRPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCF
VEVKGVTFCGTSTSASAGLTMQNVPFYEEVVAFVVALNAELTRRGLGYGIAAEHKHSCCV
LLASNRFYINDRWHTRIDYDKFFTLLEKEKNNGISFRPEDYMRETEEWALWGNGGFDPND
TRVYTRGRNKAKLNAVLKASEQNATSVEG
>Q5UY61|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A183IHP2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Soboliphyme baturini|TrEMBL
MAILFIAVFLFVVVVYLSVSLTYGKSRLNDAALRLFGIRKLNIFYATNGGIAKKYAVELA
VRLKPICTIRLVNLETYDPEDSLQHENDISLFIVSTFINGFPPENCRWFFTWVNDAASDF
RYDHHLLHKLKFAVFGIGDSVYGEDYNKVAKSFRNGLLKLEAKEIIPLKLADESCSVDEG
GYHSYTWRLISRLFSAGIDESFELWANRLMEYLSRVIDDKNDCQPTSTVVTWGDKETLPS
VTVEVTDLEDILLTIPKQGIQLREMITPSLRQSLSKQGYKLIGSHSGVKLCRWTKSMLRG
RGGCYKNTFYGINSHQCMEVTPSLACANKCVFCWRHHSNPVGTSWNWKMDDPEFIFQEAI
RQHLKIIKENRGLPGVKEDRFEEAHNVKHCALSLVGEPIMFPKINEFVDILHRHGISTFL
VTNAQFPEEIRKLQPVTQLYCSIDASTEGSLKQIDRPLFKDFWKRFIDSLTALRDKQQRT
VYRLTLVKGYNTSEIEQYAKLVELGSPDFVEVKGVTYCGTSKDSHLTMENVPWHSEVICF
GIKLMEHLKDYEIATEHKHSNCILLAKTKYKINGVWHTWIDYAKFQELYQLYVTSGKRFS
SMDYIAETPHWALFESEEHGFNPADVRWYRKNRKVVPE
>A0A2G4JCS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosarchaeum sp|TrEMBL
MSCSGETVEEEDQLIQIKPGIVQQLKKAKYGVADHSTVELCHWTKKSFKHEGNCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSMKMDPQKVAEPKEILTKLMEERRKLIM
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLETTKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSFLKINKPKYDDSWQRWNKTLGMLQHLDTRTVL
RITLIRNYNDQNEMIPAFAAMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEIRKFS
EEIAKQSEIFSIMDESLVSRIVILQNNHRTIDRMISSYANTN
>A0A4Q4PRF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria tenuissima|TrEMBL
MALLELLEHLPAELLFIWHQHRLPILLAALVVATVVRLAIYSRDRREKLSVSPAPSSPVP
VEEKPTVQLKPEWLPEYTTLNSSELNVDNHAEDDTRAVAAAAKVKKGPKMVKGRKTPKKL
IAPPTFNHQTDRIQPLVFFQSLSGTTERYAKQFAGVLAEWTRGCDQSKSFLEPQTLDISY
IEHDDYFISPPKGDANVKYFYIILVPTYNIDTVLDVFVESLQETHNDFRIDTAPLSGLVG
YTVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMADVKSEAEERLQDWRV
GVQDALVEIAEGRGLGEGVPGSGDPIESDEEDVAEENGQSTRVDDVEDLGSMVNSSAGPI
PVDFTTYKKSPAKSQSLQAPKEMVPTTSPTYAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDMIFDGIT
TAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLGIMHSNRISTFL
VCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMENVPFYE
EVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRNDRWATRIDFERFFDLYE
GKVEGTRVEDGKVVGWRPEDYVGEETPEWALWGNGGFDPRDARVYRKGKGPKVSEEGGKA
TAAALEF
>A0A7C5P3S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLAPSPLISVLKRQRYHIVGRHSAVKRCRWLYETLIHDRPCYKQKFYGIKSHQCIQMTP
VLYHCTQRCLFCWRAQSGDLQIFWDETKLPPWDSPEEIVEGCINAQLQILSGYKGNPKAN
PQKFKEALIPRHVAISLTGEPTLYEPIGDLIEAFHKRGFTTFLVSNGTVPSALAKISHEP
TQLYISVCAPNEEIYNKVCRPLNPDSWRKLNETLELLNSFKCPTVIRITAVRGLNMGPIS
DYAKIIGKANPTYVEPKAYMHVGFSRLRLGYESMPSHREIREFALQLAKELSYNFLDESE
DSRVVLLSRLKSPIKFSK
>I1RZH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEHVEIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPFVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKEYGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>L0AHZ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronobacterium gregoryi (strain ATCC 43098 / DSM 3393 / CCM 3738 / CIP 104747 / IAM 13177 / JCM 8860 / NBRC 102187 / NCIMB 2189 / SP2)|TrEMBL
MSEPADSGVGPGIDADDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIWYGI
ESHRCIQMTPVVKCNERCVFCWRDHQGHAYELGDVEWDDPEAVVDASIDLQKKLLSGFGG
NDEVPREVFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTNPDVLRE
CEPTQLYVSVDAPERHTFDEVVKAVADDAWERLLETMAVLAEKDETRTVLRTTLVDGENM
HHPDWYAGFYRLADPDFVELKAYMHVGHSQGRLDRSSMPDHETVAAFAREVGEYMPEFTE
CKEVPPSRVALLSKTDDTWVPKLKKESEFWAREPDR
>A0A3A5WCM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPLEMLYESVRAQRRLLSGFGGNPKVPQEKFLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHSHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKEVFDEICRPKWNSAAWDKFDETIDLLPSLDTRIVCRHTLIKGKNMKPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHDDILEFSNALAPLTDRKLLDDSPPSRVALV
GREIVPIPIPEASMHFPEDLGIAESIKHLKIVQ
>A0A2H3FRT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella zeae|TrEMBL
MDWANHSSPSRLDSFVDELVDVWHLHRTPILFTTCIILVAIRIYFQFNGQKTEVIAFKKA
YEEPAKPKVAVEEVKVEHVEIEEKTPTIEPVEEKKNAKSQGPRRIKGGLARKPSKKTEEE
KDISRPVVPFVFFCSVTTKTAKIAQAYVEKLGGKLDELSKQSGRQFLKPETRDLTEIDFD
DYFLTPYKEYGDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVF
GFGDKENWPTEADGFCFQAKEVDKWMAKLTGRKRAYPVGMGDMQSDHEERLQEWTQGVEE
VIEYVARTGSLGEGLPGSGAADESDVEDIAEDEDDGEVIIEDDATDKKTKGGRDLDDVED
LGRMIRKDDGSTVQKAPLAVDFTNYGSSTKKAVPQGPKKMVAEESPTYKALTKQGYAIVG
SHSGVKTCRWTKSALRGRGSCYKWSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGT
TWRWVVDPPDLIFDGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPY
INEFLGMLHAERISSFLVCNAQHPDQLADLKAVTQLYVSIDAADKESLRRIDRPLHRDFW
ERFNRCLDILREKRFSHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGT
STSSNAGLSMSNVPFYWEVVDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDE
KWHTLIDYKKFFELLEERGAGNFTPEEYMGAPTPEWALWGNGGFDPRDDRVDRKGRKIEA
S
>A0A101DCZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus fulgidus|TrEMBL
MMNEKLLSELKGYQIVGKHSAVKTCLWLKKSLKDEGVCYKQKFYGINSHRCLQMTPALMC
NQNCLYCWRPLELLKGFRGWDEPEFIVEESIRAQHRLLSGFHGTEGVNRKKLEEAYEPNQ
VAISLIGEPTLYPMLPELIEEYKKRGFTTFLVTNGTNPDMLEKVKPTQLYLSLTAFDEDS
HLVLNRPGKSNWERVLRSLEVMRDSGSRTVIRLTLIRGYNMDEEAIRKYSELIEIAEPDF
IEAKAYMYLGYSRLRLRWENMPEHADIVEFSRKLADSTGYEVKRESEPSRVVLLERVK
>A0A662PE42|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococci archaeon|TrEMBL
MQRELLLRQGYKLVGKAGGVKLCHWTKESLRGDRYCYKQKFYGIESHRCIQMTPSVFHCN
LNCLFCWRYNNYPYVEMKEWDDPSYLLEKSIEAQRALISGFGGNPKVNKEKFEEAMEPKH
IAISLAGEPTLYPELGEFIEEAHRKGFTTFLVTNGTNPKALEELDPLPTQLYVSVTAPNE
RVFEALNLPRVPRAWESLIETLRLLPSLGTRRVIRHTLVKGWNMPFVEDYVKLDSIAEPD
FIEPKAYMNLGYSRYRLNPGNMPKHWEILKFSEELSKELGYHIVSESKESRVVLISKRKS
GIKIAQ
>A0A2E0BU31|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRSCYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPKEKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSSHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNRDVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLIQN
>A0A2H3SKC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella fujikuroi|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILIAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKGVKSQGPRRIKGGIARKPSKTKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYVEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>E6N924|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldiarchaeum subterraneum|TrEMBL
MTGLTQVVPLNEVEKPRREGVKGVEKFSNAGYRIVGRHSAVKVCHWTKSALKGGKMCYKS
WYGIASHRCIQMTPSVQYCNMMCVFCWRFHTLNRVQPYDGEWDKPEEILERMIAEQRQLL
SGFGGNPNVSKERFREAMEPMHIAISLDGEPTLYPYLAEFIQLASSRGMTTFLVTNGTMP
ERLEELLQKAQPTSLYISLYGPDKETHVKTCKPLIKDSWERLLKSLELMGRFSCRKIIRL
TLVKDVNMHSPEKYGALIRNASPDFVECKGYTHVGESQLRLKKENMPSLEEINKFAAELA
ASIGFIKVAEDEVSRVVLLANPSSPHYLEAIKQGSSA
>A0A6A3MZQ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora rubi|TrEMBL
MLSPSASAGVSLLLVAVGVLLYLSSHPHTLPRNAAAIDSPKRKAKKSPRKAQDKPKDKPS
EPKPMTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEDIV
VAVLSTWTHGKPPEDALVFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAA
KNLDRELSELGSPSLVQLGLGDDNIDQFKQFDVWMDNLVAAMCEYSSEKAVAALKKSDSP
VKAGKKEWLSQNEFRRQKRAKKAEVAAANGETVELNEEDLMNEQFLVDEFSDDEEQNQEK
ADDDSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKH
QLRGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLV
KGSIERHQGMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHI
SSFLVTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKHK
GQRTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEE
VRGFCSALCDRVSGEYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELVTKFYED
GTPFTADDYTAPTPHWAVYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A817J0C8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sp. Silwood2|TrEMBL
MAVDLYIFAAGTALTGLKSSSKSQSLTKIISQEKNGITIVFGSVKGNSQTFAQLTYDKLS
NELNRQVILQDLNDITDPEEFLQIQTKNQRILLIFISTYEDGTPPPSAKWFVLHLQEAAT
DFRVSKNELEKLTYAIFGCGNSLYNDNFNKVAQELDRCLLELAAKQLIPTELADENTAKS
LEGHYSKWSSQLISAFQSPKTEKCDCSNENSINCCQSSKNNEHSIEKKDNGEQLRIESDD
DDEDGGCKNGNDDVMDLEDMGDYMETHSPNKTTKGPPKEMITPLIRKSLEKQGYKLIGTH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSW
QWKTDDAQTVCQGAIENHYKMINTFKGVPGVLPSRLAEGMKIRHCALSLVGEPIMYPHIN
ELIDLLHSKQISSFLVTNAQFPHEIRSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWER
FLDSLRALKDKGQRTVYRLTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSSASH
LTMANVPWHEEVVTFVQLLCDRLPQYDLACEHEHSNCILLAHNKFRVDGKWHTWIDYERF
HELVTRHKATSGVETFTSLDYMAVTPDWAVLGSNERGFDPSDTRWYRKATAKKNLSGC
>A0A6G1FX88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eremomyces bilateralis CBS 781.70|TrEMBL
MDIAPEFPAWPFELLELWHENRLNLLAAIVIVGLAVRLISWKRETIKETRPKETTQLHNE
KISSGETSRRVLENRLPKRVTGVRQSKPARDASITGIRAIQLHVFYFSLTTTTEKTAKRV
QQELDEWSGKPSSAGGPDCDVSVVLYDLSEIEYDDFFVSPPRHTESTTKSFYLMLIPSYN
IDTVMDTFIEQLKETHHDFRIDTASLSGLLGYSVFGIGDREGWPTESEGFCCQAIEVDKW
LARLTGQKRAYPMGLGDAKSDATERLQEWVQGIERAVRDIFLAGGLGEGVSGSGEALESG
DEDDEIMDPKKNPSKRRRAERIDDMEDLDRMIQKDASDDAPLAIDFTTYGKSKPGPPIVE
RKEMVPKSSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCME
TTPALSCSNKCVFCWRHGTNPVGTTWRWKIDPPELIFEGVKAGHYKKMKMMKGVPGVRAE
RFEESMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNAQHPDELAALKPITQL
YVSIDASNKESLRKVDRPLHRDFWERLMRCLDILRERRFRQRTVFRLTLVKGFNIEDEAE
GYADLVEKGLPCFVEIKGVTYCGTSTSASAGLTMQNVPFYEEVTEFVVQLNAALERRGLK
YGIAAEHAHSCCVLLASTRFHIDGKWHSTIDYDKFFECLESGKEFGPEDYIGPPTPEWAT
WGNGGFNPEDTRVFRKGKNKTIQQTVEI
>A0A8J7Y0S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theionarchaea archaeon|TrEMBL
MHPELKTLLKRQRYRIVGNHSAVKLCHWLRRSLLEDRFCYKQKFYGIKSHRCLQMTPSVT
ACTQKCLFCWRPTQFTETQLREHDPPDFIAEESLKAQKVLLTGYFGLPDRVSADKLKEAL
TPTNVAISLAGEPTLYPELSDLITEYKKRGMTTFLVTNGTSPEVLETLELPWNLYLTLAA
PTKSIYKKLCHPQTNGWEKILKSVHLFSALPTQRVIRLTLVKEFNLTNPQEYARLIEKAA
PNFVEAKAYMYVGYSRYRMTIDNMPSFEDIMDFARAIEVNSSYTISDFQKASRVVLLKRE
>A0A8B9JZJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
VSNIWYVEFHIYASWISCHAVRKSYFLFLSLQCTSKMICVFLVATYTDGKPTENAEWFCK
WLEEASTDFRYGKTYLKGMRYAVFGLGNSEYVGHYNTVGKNVDKWLWALSASRVLSRGEG
DCNVVKSRNGSVQADFQAWKAKFLTRLQALARGEKKACSGKCKKSSCKNKKEHQQEAVDE
HQEKHSSEELFESSSDSESAGEEEKAHGSVIDMEDLGNVMNHMKKAKSEEESQRGKLSKL
NGVMKTEGEEEAREMITPALREALTKQGTACLCQLHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCA
LSLVGEPIMYPEINAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSL
KKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIE
VKGVTYCGESSASSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFK
VEGEWWTWIDYERFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQ
RKNKTKDISGC
>A0A6B0HGN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba sp. INN-245|TrEMBL
MSDSADTGDSLTGAGTDAEGGDDGGPAQVSSPNYHSENHTAAQTCGWTANALRGEGKCYK
NIYYGIESHRCIQMTPVVRCNERCVFCWRDHNGHAYEMDDVEWDDPEAVVDASIDLQKKL
LSGFGGNEEVPREVFEESMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVKAMEDDAWDRLLKTMDVLAEKDETRTVLRTTL
VKGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSSMPDHDEVVEFAESIREY
MPAFTECKGVPASRVALLSKTTDTWVPKLKKDSEFWERDAVTGD
>A0A4Q4NER6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Alternaria alternata|TrEMBL
MALLELLEHLPAELLFIWHQHRLPILLAALVVATVVRLAIYSRDRREKLSVSPAPSSPVP
VEEKPTVQLKPEWLPEYTTLNSSELNVDNHAEDDTRAVAAAAKVKKGPKMVKGRKTPKKL
IAPPTFNHQTDRIQPLVFFQSLSGTTERYAKQFAGVLAEWTRGCDQSKSFLEPQTLDISY
IEHDDYFISPPKGDANVKYFYIILVPTYNIDTVLDVFVESLQETHNDFRIDTAPLSGLVG
YTVFGFGDREGWPTEEEGFCSQSREVDKWMARLTGRKRAYPLGMADVKSEAEERLQDWRV
GVQDALVEIAEGRGLGEGVPGSGDPIESDEEDVAEENGQSTRVDDVEDLGSMVNSSAGPI
PVDFTTYKKSPAKSQSLQAPKEMVPTTSPTYAALTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDMIFDGIT
TAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINELLGIMHSNRISTFL
VCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMENVPFYE
EVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFKRNDRWATRIDFERFFDLYE
GKVEGTRVEDGKVVGWRPEDYVGEETPEWALWGNGGFDPRDARVYRKGKGPKVSEEGGKA
TAAALEF
>A0A1G0ADP1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon RBG_19FT_COMBO_69_17|TrEMBL
MDPERKEVLERQGYRIVGEHSGVKLCHWTKASLSKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLGCMFCWRTQEWGSDGLLEADDPSSIVDGSLEAQRALLSGYKGHPGVTRERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDDFKRRGMSTFLVTNGTTPAVLRRMREEGRLPTQLYVT
VAAPNEDVYRRLMAPKSDHEWAKLLETLALLPEIPTRTVIRHTLVEGWNLGWEDEYAALD
RVAKPMSIECKGYSFVGESRLRLREENMPSHASIRTFARALADRLGYAVAAEREDSRVVL
LTPDGELHPVSS
>A0A2K6QU09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhinopithecus roxellana|TrEMBL
MDLSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRNLQEKSVPKAPQN
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKVTSKNVCVFLVATYTDGRPTESAEWFCKW
LEEASSDFRFGKSYLKGMRYAVFGLGNSAYSSHFNKVGKNVDKWLWMLGAHRVMSRGEGD
CDVVKSKHGSIEADFRAWKTKFISQLQALQKGERKKYCGGHCKKGKCESHQHGSEEREEG
SHEQDELHHRDTEEEEPFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQ
EEKSGLFRNMGRNEDGERRAMITAALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQ
NMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNA
QFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRL
TLVKAWNVDELQAYAQLVFLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVREL
VDLIPDYEIACEHEHSNCLLIAHKKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAK
DYMARTPHWALFGANERGFDPKDTRHQRKNKSKAISGC
>A0A7M5WQH8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clytia hemisphaerica|TrEMBL
MLKIIIKALIALSVVEAVICQSTTLSHDFVIWWSYARFPITGFVFGTIILTWVWIYLNRD
RFVEKKNESKNDQKLIDEYEQQRNQPTLKIFYGTQTGTSEKFAGDLMKAAAEQGLSATVI
DIKEKDPEQLLTNQTDGKSICVFIVSTFVDGTPPESCNNFWTFISDSVNDFRVSKLMLKG
MKYTVFGLGNSLYKDSQDVDNYNVFGMNLDENLERLSATRYCKLGLGDDNIQRKDLGNIS
EDFKEWYGQLLKQIAKDSVTKEEKINGVTPHEDSNGSVKKVSDEKPATNGDVNYESESDS
ENTTSGGGGCKSGAGDDGGLVDVEDIGVVMGKVKQTESEFDEGFVGEKSAPNNREMITPM
LKKSLEKQGYKLIGSHSGVKICRWTKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANK
CVFCWRHHTNPVGTEWKWKMDEPKKIVDGALENHYKMVKQFRGVPGVKAERYTEAMNVQH
CALSLVGEPIMYPEINELINLLHSKMISTFLVTNAQFPDAIRNLKPVTQLYVSVDASTKE
SLKKIDRPLFRDFWQRFLESLTSLSDKGQRTVYRLTLVKAFNTEEIEGYAKLVSLGKPGF
IEVKGVTYCGDSKASSLTMENVPWHQEVVGFVQQLAESLPDYEIASEHEHSNCVLLAHKR
FKINNKWHTWIDYPKYHQLMKDYEESNGTKTFKDIDYMEITPEWAVFGNPHRGFDPDETR
WHRKKKADVTGGC
>A0A835ERQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Digitaria exilis|TrEMBL
MTVGRGPPGRPSSSALLGCWRRRPPLGFGAKVGIAIALGLSFAIIWTSVSPTLSSQQIST
ERSSFAAEVAAPPTATDNRTSASAGGGHAHRKPRPAPHSHKKRHPAPSGSHPHPHRSNAT
ASPDAADEKADHSDSAPITDPEPKEKEPQQEQEPDMEMEPEQEAELPMPEESGDKSGKAP
AEGEEEKPPQLELEEEPGEGDGDEDFEEAAKKTAPSKKRKLPPLFNPGAHYHWKHCGAKS
GYHYIPCVDFDGDGSQRHHERSCPRSPVTCLVSLPKDYKQPAPWPERKDKVWYGNVAHPR
LSNYVKGHSWMNHSGEYLMFPPDEWEFKGGARHYVQSIDEMAPDIDWGKNIRIILDIGCK
SAGFGIALLEKDVITLSLGLTNDQTDLAQVALERGVPATVGSLGSRRLPFPSGTFDAIHC
GECNIPWHSNGGKLLLEINRILRPGGYFIISSKSADLESEEGISASMTALCWNAISYNSD
DVSEVGVKIFQRPATNEEYDLRAKKDPPFCKEEQNKANAWYTHIKHCLHKAPVGIEERGS
DWPEEWPKRLESYPEWLGDLQTRVAADHNHWKAVVEKSYLDGLGIDWSNIRNVMDMRAVY
GGFAAALASKKVWVMNVVPVHAADTLPIIYERGLVGVYHDWCEPFSTYPRSYDLLHADHL
FSRLKIRCRQPVAIVVEMDRILRPGGWAIIRDKLEILDPLETILKSLHWEIVMTFRKDKE
GIMSRLSARLTADAEAGVPVRATDASAFDPDDLPSVPLLLLVVPTHDGGAPPPSAAFLAR
WLEESAADFRAGALLLSGLRFAIFGVGSRAYGETFNAAARSFSRWLRALGAVEVVPLGEG
DVDGGDLDSMFEDWSGKVLRVVKGEELDEGLLGESNGLNELELEGEESDDDDEEEAVAGE
IDMEDIAGKAPARRQNGKVESSLANGGQNGVKEMVTPIIRTSLEKQGYKILGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWKWKMDE
PLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGLSPRHCALSLVGEPIMYPEINALVDEL
HRRHISTFLVTNAQFPEKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFWERFLDSLK
SLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLNLGLPDFIEIKGVTYCGSSATSKLTMENV
PWHSDVKEFSEVLAAKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWIDYDRFHELV
TSGKPFKSQDYMSMTPSWAVYGAEEGGFDPDQSRFKKERRHGTAALQA
>A0A7K5VDP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Platysteira castanea|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVGEDLLQELGA
DKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRCLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTR
LQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGKSEHENSEAEELFETSSEEEAGG
TDSVIDVEDLGNIMGHMKKAKVLLLEGVWNGSKEEAERREMITPALREALTKQGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WRWKMDQPEVILREAIENHQNMIKQFKGVSGVKAARLEEALSVKHCALSLVGEPIMYPQI
NSFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSAS
SLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHRKFQVDGEWRTWIDYGR
FQELVRERERSGGSRAFTAAEYTARTPPWALFGARERGFDPLDVRFQRKSKARDISGC
>A0A7J3XGT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MVTCIGGVDPLTRAYERLRKQGYHLIGSHAAVKKCLWVHNALAYGKFCYKCRFYGIESHR
CIQFSPAVLWCWNSCLHCWRLRPSDFGLEGVELLKLPYVEDPEVLAELAIAEHRRTVSGY
AKRASNEMYKEAIDPKHVAISLTGEATLYPRLGELIQVFHRKGLTTFLVTRGVRPDVLAN
LEEEPTQLYVSLEAWNEEMYKYFSRPMGGGLWRLTLKTLELLPSLSTRTVIRITLVKGFN
MGDDDVRGFAKLIERANPTYVEPKAYMHVGASVGRLSRASMPTYEEVMEFAKQLAEETGY
RLVSSSRPSRVALLTRL
>B7R050|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. AM4|TrEMBL
MAIVVKANPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQFYVSLTAPDIETYNRVNVPMIPDGWEKIKETLKLMRDAETRTVIRLTLVKGE
NMHSPEKYAKLIKIANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPRGRGLTGRFIAD
>A0A3M7JRE6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus flavus|TrEMBL
MAELSLAEGLVTFWHSYRLPILIAIASVAILLRAYRKFQPKSKAVTASSIPPSPRSQTPE
KFEQIRTGESEKPVVVEKSVPKAATGNDPTPKVVSGPKRVFGKKPLKVAGRRREDQGAPL
SFIQPIIFFASLTATTERYAQILLEDLRAAAKERADPENRERGLLPPQIHDLSYIDFDDY
FTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGLGDVKSDAESALKEWSRGLQ
DILVDILDNGGLGEGVAGSGDPLESDEEDLDDEENDGNRSKRRNGQDVVDLEDIKMGSDG
PSGSGPVPVDFTTAGKSAAPNQSTVKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTK
SALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPDLI
FQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHSEH
ISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILRE
KRHVQRTVFRLTLVKGFNVDDEVIGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQN
VPFYEEIQEFVVSLNKELERRGLDYGIAAEHAHSCCVLLASTRFHVNGKWHSRIDYDRFF
ELLEKEKADGTSFRPEDYMRETEEWALWGNGGFDPNDQRVHKKGKKKALQAATE
>A0A6V8CHJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDPKLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRGRQCYKGRFYGIESHGCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNDKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMELCHKHGMTTMLVTNGTLPKVIENLDTLPTQLYVSVDAP
NKAVFDDICKPKWNQGAWEKFEETIDLMPSLDTRIVCRHTLIKGKNMSHDHIREFASLDN
RADPDYIEAKGYVHVGHSQENLAANNMPTHEDIMAFSREIAPLTNRQVLDESRPSRVALI
GTEIIPIPVPEAELYFPDDLGIAPPIKHLPVI
>G0HJA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. (strain CGMCC 1.5172 / 4557)|TrEMBL
MALTFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYNIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPSQLYVSLTAPDVETYNRVNVPMIPDGWDRIKQTLELMKDAETRTVIRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGYSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSHGTGIGGRFIKH
>F7EUX6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Macaca mulatta|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVSKTQDRSLQEKSVPRAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKVTSKNVCVFLVATYTDGRPTESAEWFCKW
LEEASSDFRFGKSYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGD
CDVVKSKHGSIEADFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEG
SHEQDELHHKDTEEEEPFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQ
EEKSGLFRNMGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQ
NMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNA
QFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRL
TLVKAWNVDELQAYAQLVFLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVREL
VDLIPDYEIACEHEHSNCLLIAHKKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAK
DYMARTPHWALFGANERGFDPKDTRHQRKNKSKAISGC
>A0A7K9QVB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Irena cyanogastra|TrEMBL
LDVSMDMWSYFYTCLVSIWLHRFYIYSAVAFGISLWIAIQFTTTRTKRKKSYGNPSSPKR
TADKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFANALAEAVTSLNLPVEVINMEDYD
PEDSLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSILQGLRYAVF
GLGNSAYVDHYNTVGRRMDRCLWMLSASRIMTRAEGDCNVARSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGTSEHDNTEAEELFKTSSEEEA
GGTDSVIDVEDLGNIMGYMEKAKVLLLEGVWNAAGAERREMITPALREALTKQGYKLIGS
HSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTE
WQWKLDQPEVILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCALSLVGEPIMYPHI
NRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFKDFWQ
RFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDFIEVKGVTYCGESSAS
SLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQVDGEWRTWIDYGR
FQELVREHERSGGSRTFTAAEYTARTPRWALFGARERGFDPLDVRFQRKNKARDISGC
>A0A087UCZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stegodyphus mimosarum|TrEMBL
MDNSVLFCWHFAVTISIVGLAYFIVNLFLFRNKNKSIQNSKPETEKYCDIIFGTQMGNAK
VFAEDLAQTLKTINWIVVVHDMKTLDDPEEYLKIQASKEKLCIFIVSTYIDGQPPENCHW
FCKWLDEASCDFRISRVLLKGLKYCVFGLGSSLYEDNFNKVAVGIDDALKKLASTSVLPL
VKADENAETSLEDSYNMWKKDLKETLCTENMLKEEATENEQEKEIISESSEEEEEVMDLE
ELGSAFTKKNPQLEENKGPKEMITPILRKALTKQGYKLLGSHSGVKMCRWTKSMLRGRGG
CYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWKWKMDNPGEIVDLALKSH
YSMIKEFKGVPGVKPERLSEGMEVKHCALSLVGEPIMYPEINTLIRLLHSKKISTFLVTN
AQFPDAIENLDPVTQLYVSVDASNEQSLKKIDRPLFKDFWQRFIDSLQALSKKGQRTVYR
LTLVKSWNTEEIEGYAKLVEIGKPDFIEIKGVTYCGTSNASNLTMDNVPWHEEVHSFGLK
LAESLSGYKIASEHEHSNCILIAHKKFYINGKWHTWIDYEKFHLLVKEFNESNRTKSFAS
LDYVYP
>H2L7B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
AAPQTGSSLAENYLALLWHHRLYLYAAAALVVGLWVSLKVIFGMFNFSLRLCFQKSGEKD
AVLSGAKKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELEALGFPAEVIDMKDYDPDD
RLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYGRTYLKGLRYAVFGLG
NSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSVQADFQAWKGKFLSRL
QALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEVRRREEGVLLTVTKLRDGEVVK
FSKLNGVKKIDDDGERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALDKHQDM
IRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQF
PEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTL
VKAWNVEEMQAYAELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAA
MLPEYEVACEHEHSNCLLIAHEKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDY
MAKTPSWALFGAREQGFDPADTRFQRRNKTKDISGC
>A0A0D2A582|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verruconis gallopava|TrEMBL
MFSLFNIGSLPSEALELWHVHRTPIILAIAVILIVFRVWIRFSCRDQEDIIDLNREKSID
SAETRTMNHKPPIDHAPIEFGFDDNNFKAADVTKTSKVRGKLSPKRVNGKKRQAKPFSNL
PSQGFDPEQDSVKPLVFFCSLGGNTEKAAKDFAADINSWRKTLDAPCKDRILEPEILDLS
YIEYEEYFVTPPADSKVESANKRPKYFYTILLPTYNIDSILDNFLDHLKETHNDFRIDTA
PLSPLLGYSVFGLGDREGWPTEQEGFCSQAREVDKWMAKLTGRKRAFPLGMGDMKLDGKQ
RLFEWRTGLQDVVLEIAKGNGLGEGVVGSGDAIESDEDDTDTEEANASQSLDDVEDLWKS
YRNRMNGPVPVDFTNYNSNSKPADSTPLKEMVPKTSPTYAALTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPP
EMIFEGVKEGHYKKIKMMKGVPGVRADRFAEAMQIKHCALSLVGEPIFYPHINEFTRMLH
KEHISSFLVCNAQHPDQLAALNHVTQLYVSIDASNKDSLRKIDRPLHRDFWERFIRCLDI
LREKRFTQRTVFRLTLVKGFNIDDEAEGYADLVARGLPCFVEIKGVTFCGTSTSSSAGLT
MQNVPFYSEVCAFVVALSKALSNRGLKYGIAAEHAHSCCVLLGDTDRFLINGRWHTQIGY
EKFFQCLESGKEFGPEDYIGDPTPEWALWGNGGFDPRDEKVDRKGNKQDLPVSGARLVEI
>A0A0D2DM46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala oligosperma|TrEMBL
MDLGEGGATPVILADWLDRLLSSWHDYRVPVYSAVALSCLLFWLYRRRLRTTQARTSSDW
LDGKHNIPLPTTNGNPSLENGPQPAAGTNRKPRYSAPKVVTGRKPSPRGGGKGSQAHDEP
LHIQPLVFYTSLTGTTERLSRSVLAKLESLPTVQSLVLKPQLHDLSYVDLDDYFISGPKT
PKSDTNVRYFYILLLPSYDIDTILNTFLDHLDETHNDFRIDTASLSSLAGYTVFGIGDKN
GWPTEEAGFCSQAVEVDRWMSKLTGSKRAYPLGLGDVKGSIEQTLQDWTAGVCDVLQELS
VTGGLGEGVPGSGDAVESADEDDRDEEDMQEDVDFPDSGRNKRRKLRNTTDLEDVGGKGT
TMAVDFTTYSSSPAAVAPLKAMVPKESPTYTALTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQMIFDGAKE
GHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPHINEFVGLLHGEQISSFLV
CNAQHPQQLRDLRRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQSCLEILREKRFIQR
TVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEIKGVTYCGTSTSSNAGLTMQNVPFYEE
VVAFVEALDRALTKRGLEYGIAAEHAHSCCILLASKRFLIDGKWNTIIDYDKFFKLLGDG
VDFAPEDYCKETPEWALWGNGGFDPRDERVDRKGRPKEKKMVKEATTTTMPLEEKQSLEF
>A0A7J2GY70|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MEKEVEMLLRKQHYGIVGENGAVKLCTWLKKSLHDKGFCYKQKFYGIQSHRCLQMTPVAN
LCNHNCLFCWRAMDYSRSRVRKFDPPELIVEESIREQQRLLTGFKGDPTANQEKVKEAFE
PKHAAISLLGEPTLYPYLKELIEGYHKRGMTTFVVTNGTKPEVIRKIKPTQLYVTLPAPN
ERIYVELTRPLIPNGWEKLNETLELMPKIRTRKVMRLTLVKKFNMVEPERYAELLEVAEP
HFVEAKAYMAVGFSVQRLGYDYMPTHEEILEFSRRIEENSDYKIIDEKRESRVVLLAKKD
YEWRNLNKAQPF
>W2Q3D6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora parasitica (strain INRA-310)|TrEMBL
MLSPSTSAGASLLLVAVGVLLYLQTHPRALRSSEVASTSPKRKAKKKPQQNGYTNSEPKP
MTVRILYGTQTGASKTMAETLEKTLFALNISGFHFQTSVVNMKDYDQDNLEQEAIVVAIL
STWTHGQPPEDAKMFCNWITDMTQDFRVSKSWLNGVQHAVFGLGNAEYDEDYGTAAKNLD
RDLSDLGSPSLVSLGLGDDNVDQFKQFDVWMDNLVAAMCEHSSEKAVAALKKNSSPVKAN
KAGKKWLSQKEFRRQKRAKKAEANGETVELNEEDLMNEQFLVDDFSDDEEQSKQNANDDS
GMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGR
GGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSIE
RHQNMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHNRHISSFLV
TNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLKELKHKGQRTV
YRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGFC
SALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYERFHELIATYYEDGTPFT
ADDYTAPTPYWALYDSKEQGFDPVETRFRRTKDGKVVEFAYQSTESGCG
>A0A8A2VCE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena sp. KZCA68|TrEMBL
MSDSADGAAGSAPGDERDEGEDGGPMQVSSPDYHSENHTAAQTCGWTANAMRGEGKCYKN
IWYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDDVQWDDPEAVVDASIRLQKKLL
SGFGGNDEVPREVFEQAMEPRHVAISLDGEPSLYPYLPELIEAFHDREITTFLVSNGTRP
EVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWANLLETMDVLAEKDETRTVLRTTLV
QGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSRGRLDRSAMPDHEDVVDFAESVREYM
PEFTECKEVPASRVALLAKTSDTWVPKLKKDSEFWERDPVTGD
>A0A8J4MK39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spheniscus mendiculus|TrEMBL
LDVSVDMWNFFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKYNGN
PASSEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
SMGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WRAKFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFET
SSEEEADAEEAGGTNSVIDVEDLGGIMSHMKKAKSGLDSRVGGGMYHPFPRLSRNPIRTP
ILAAQGGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCA
LSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIE
VKGVTYCGESSASNLTMANVPWHEEVVHFVQELANLIPDYEIACEHEHSNCLLIAHKKFK
INGEWCTWINYDRFQELVQEHERSGGSKTFTAADYAARTPLWALFGSRERGFDPLDVRYQ
RRSKARDISGC
>A0A8C5DTF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
LDFCVILWSFRVFLWLVCVFLGSFCVCACCQLLIYIYIYIYSTYTFCVFWLFVCFLSHFD
NFIPAVWVFSLSFCVFFGLCDVCVISRCVQGFAAELSEEVKTLGIPSEVIDMKDYDPDDQ
LADECTSRTVCVFIVATYTDGRPTENAQWFCKWLEEASTDFRYGKTYLKGLRYAVLGLGN
SAYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQDDFLAWKAHFLRRLQ
ALARGDSGSRSSKSSCMKTDGADHEGEEPTLTNHSSEEELMETSSDEEQSDERTSGSVVD
VEDLGNLMDSVKKSKVPETHVSVIQKVSSILLLFRKRKLWILYPRVCLRNMYSRVKSLFA
GYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHH
TNPVGTEWLWKMDPAEKILEEAMEKHQNMIRQFKGVPGVLPERYQEGLAIKHCALSLVGE
PIMYPEINTFLRLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRP
LFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVTY
CGESSASTLTMANVPWHQEVVAFVRQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWR
TWIDYERFQELVEAHEASGGTRSFSALDYMSQTPHWALFGAQEQGFDPADTRFQRRNKTK
DVSGC
>G7VB58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrobaculum ferrireducens|TrEMBL
MSCEDVALGRYHVLEGPRLRIRASAGRALVERHYGFVGHAAVELCKWTKDAVEGGKSCYK
VKFYNAPAGGSHRCVEMSPVGLVCSNRCVYCWRPTEEFDAFVLDERLYMEPEEVVRGVLE
ERRRLLSGYWGHPEGRKRVKDALAPTHWAISLSGEPTMYPKLPQLIKLVKSLPHTKSVFL
VTNGQHPDMLRRLIEEDALPTQLYLSTNAPNRELYYRINVPVYNVEDAWERWLESLDIIA
KAPTRTVLRITLIRSLNYDDRYIPEFAQIVKRGNPHFVEVKSYMHLGHSTFRLRKEDMLS
HEEVKEWSRKLLGELERLGARFVYMDDDEPSRIVVLQNLDRYVDRWIVPPGSA
>A0A833DX54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus profundus|TrEMBL
MITKKLLKDLKGYEIVGRHSAVKTCFWLKKSLKNEGVCYKQKFYGIQSHRCLQMTPALIC
NQHCVHCWRPLELLTNIEGWDDPEFIVEESIKAQRKLLSGFWGNEEVDKKKLEEAYNPNQ
VAISLIGEPTLYPYLPELVEEFKKRGFTTFVVSNGTRPEMIESVEPTQLYISLTAYDEES
HLRLNRPVRSFWDNIMKSLEIMSQKTCRTVIRLTLIKGYNMDAEKFAPLIEKASPMFVET
KAYMYLGYSRLRLPREAMPEHEEVRRFAEELAKITGYEIADESVVSRVVLLKAT
>A0A7C8RIF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MAEMYKSRSPDLIELWHTIRIPLIIAIGVLYITIRLRSILRARTPVLTTPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPTKPNVDAPPAVEGG
EEITQPNGKSIQVFIFYSSLTGSTAKYAEKLSNDLFSEPLHIPKPTPPSVDNAEPGPVVE
KATFLAPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFP
IGMGDVKGDALDSMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPPKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLQYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYANLVEKGLPAFVEVKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNEALQKRGLGYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQRFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTA
EEVAAELAAEAAEAESGCG
>A0A7J2VAY5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcaceae archaeon|TrEMBL
MNLSILGDRYNYVIVGSSLSLDLKSLKQKREEFWTKEPVYKAIYDRLIKQGYHLIGTIGA
VKRCHWTKEAVLRHRFCYKCLWYGIESHRCIQMTPVVAWCWNRCLHCWRIQPEDIGMHWD
DTRPPIIDDPEVLVEESIITHRQIMAGYKGNPRADQKMVEEAMNPRHAAISLTGEPLLYP
RLSELIEEYHKRGLTTFLVTHGTRPDVLKNLEKEPSQLYISFESWSRESYEYFNRPLVPR
AWELFQETIDYVRSFKSPVVFRITVVAGFNDHDEALRTFAKYIERGYPHYVEVKAYMFIG
GSRSRLTKSNMPSHREIREVAGKLSDLTGYRVLSESIPSRIVLLSRLEKPIRHGRGCPEG
VEHPEKYTPVITEEYEEIESA
>A0A4T0W424|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum higginsianum|TrEMBL
MASSLQSAGFKDVLNNAHDVWQQVRIPVILFAAFGLLVLRFYLHSTDEKGELKALPKVYN
TEKPQSKPIDEKKDVKKDEKKDIKQSSSDSVTESKAPKSNGPRRIKGGLVKRVSSDSANA
ETLVRKIRPLVFFSSITANTPKIAKEYAERLEKELQRSATGTGCSFTTPEVLDLADVDFD
DYFITPPKSENDPAELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGYSV
FGFGDREGWPTEEDGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYTERLSEWSEGVV
DVLTMLAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLIEDSEAKPEKLKNRKNIDDVED
LGRIMKSSSPDTDTTNRTAAAPIAVDFTSYGKTTQKKTPMSAAKEMVPKNSPTYASLTKQ
GYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPELIFDGVKANHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGE
PIFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRP
LHRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKG
VTYCGTSTASNAGLSMSNVPFYWEVAEFVKALEKRLNEKGLKYGIAAEHAHSCCVLLASE
RFYVDGKWHPRIDYQRFFELLEERGPDGNWKPEDYMGEATPEWATWGNGGFDPRDERVDR
KGRKIES
>A0A101J0Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon 53_19|TrEMBL
MRSKACDALRKQGYLFFSPESSAAVKPCMWSKRALRGGDMCYKHQFYGIESHRCIQMTPT
LRCNQRCLFCWRSLEHEVEEEIELAPEVILSGAQKLHKKGLAGYKPHPDVTPERWQAASE
TPNQVAISLSGEPTCYSQLPALVDLFRENGYTVFVVSNGTHPDVVEQLYPTQLYISLDAP
DEDTYTMLCRPKGDYWEQVLQSLSLLSSRRSAVRVTLVKGLNDHSPEAYGRIIADSAPTF
VEVKGYMYLGYSRSRLSMDQMPDHAYVRSFAEKIAESAGYRIRDESPVSRVVCLEEDL
>A0A832YZ96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ignisphaera aggregans|TrEMBL
MYQKLNNSCVEGYSLLKHAYDILRKQKYHIIGSHSAVKKCYWVHKALVEGKFCYKAKFYG
IESHRCIQFSPAILWCWNYCLHCWRYRPYDGTPANTRITLPLPSIDDPRFIVEMAIKEHQ
RTVSGYKMFSSINKRMYEEARNPKHVAISLTGEATLYPRLDELIYEFHRRGLTTFLVTRG
VRPEILANLREEPTQLYVSIEAYNEEHYLRFNNPISPHLWKKTMETLEMLPSFTCPTVVR
ITLIKSFNMNNEALRQWAAILKRAQPTFIEVKAYMHIGRSTTRLTRNDMPLHSEVREWAE
KLAEKLGYNVVSESKPSRVVLLSLLDKPAIRYGNPPISWHDPDYGDEFSGEYGNPEEAI
>L7LW33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhipicephalus pulchellus|TrEMBL
MCTADFPHGARXVMFQSITRRFVTYLLCALLIFHTVHAKGNVNEKSRSDWYPSSYTTTLC
GGVLAVLFFVIAREKLNLSKIKTRDPFKQRQRKRNGKSVKVLYGTQTGNAKILSEKLTAE
LDALDYDVEMVNLKHVEPEECLLGQVKAKGLCIFIVSTYVDGSPPDEATWFYDWLKDTYA
DFRVHKYYLQGLNYAIYGLGDSAYGDNYNKVAKDMDFWLSKLHATPVVPLCLNDESHDEG
KYGTGKFPGWKDDILAYLEGRPSITTQPREAQVAPEDVAYESSSDEGEPELIDLEDLGNV
RSTAKSKESKTVKNGEARPDMLTPLLRQSLGKQGYHLIGSHSGVKLCRWTKAMLRGRGGC
YKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWKWNMDSPEMIVENALKNHY
KMIKEFKGVPGVLRERLEEGLRARHCALSLVGEPIMYPEIGKLVRLXHYKMIKEFKGVPG
VLRERLEEGLRARHCALSLVGEPIMYPEIGKLVRLLHDQGISTFLVTNAQFPDALRQLGP
VTQLYVSVDASSREALKRIDRPLFPDFWQRFQDSLSTLADKGQRTVYRLTLVKEWNMDEM
QGYANLVALGKPDFIEVKGVTYCGDSKGARLTMSNVPWHDEVLSFVKQLVALLPDYSIAS
EHEHSNCALIAHNKFRVNGQWNTWIDYERFHELVQRFYQTGETFTSLDYAAPLPHWAVFG
AKERGFDPSDTRMFRKSKKDISGC
>A0A5D2RTY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium tomentosum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKFRRRCLKPLKHLPLNPNPRPGKLFFLSQTGTSKA
LSQRLLDLLSSKNNIPFDLVDPQTYEPEDLPEESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A0R2NVH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp. BACL13 MAG-121220-bin23|TrEMBL
MSCSGEIVDNDDDNLIQIRPSIVAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKF
YGISTHQCMEFSPAGMYCENRCVYCWRPMEFYDSMKMEPEKVAEPEQIMTKLMAERKKLI
DGFYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKTLEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLDMLKHLDTRTV
LRITLIRNYNDQKEMIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMSEVKKF
SEQIAKESKIFSIMDESLVSRISVLQNNERFIDRYIPTYSNTN
>A0A673KAB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinocyclocheilus rhinocerous|TrEMBL
IAQGIQCEVIDMKEYDPEDRLTEECTSKMICVFLVATYTDGQPTESAEWFSKWLEEASTD
FRYGKTYLKGMRYAVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSR
HGSVQADFQAWKMKFLSRLQALAKGEKKACSGKCKNGNCKNKKKHKEEAEDSHSLAEKNN
SEEELMESSSDAESSSEEEKFHGSVIDVEDLGNVMNHMKKAKVKTKPAPPTLNLDISFGK
GKTFQNRMSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCGFCWRHHTNPVGTEWRW
KMDPAEKIIQEAVENHRNMIRQFKGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSF
LRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFL
DSLRALGEKQQRTVYRLTLVKAWNVDELKAYSDLIALGQPDFIEVKGVTYCGESSASSLT
MANVPWHEEVVYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDREWWTWIDYERFQE
LIQEYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A2J8Q8K8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pan troglodytes|TrEMBL
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKMQGFATVLAEAVTSLDL
PVAIINLKEYDPDDHLIEEVTSKNVCVFLVVTYTDGLPTESAEWFCKWLEEASIDFRFGK
TYLKGMRDAVFGLGNSAYASHFHKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIE
ANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDT
KEEEPFESSSEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR
NEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHHCMETTPSLACANKCVFCW
RHHNNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVKHCALSL
VGEPIMYPEINRFLKLLH
>A0A1I0Q143|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium jilantaiense|TrEMBL
MSEGESGPKQVDDPDYHSVNHTAAQACGWTKNALTEGRSCYKHAFYGIRSHRCIQMTPVV
RCNERCVFCWRDHSGHTYELDGVEWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEA
LEPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPEVLRECDPTQLYVSVDA
PERATFDDVVGAQEDDAWEKLVDTMDVLYEKDETRTVLRTTLVGGENMANPDWYAGFFER
ADPDFVELKAYMHVGDSRDRLGREAMPSPERVTAFAETVQEHMSSLPVLKTDESSRIALL
ARDEDTWVPELEHGSEFWAEGAQAD
>A0A2J6XGJ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldisphaera sp|TrEMBL
MAQLKVEDVYDALNERLKKQGYHLVGNHSSVKKCFWNHAAITEHRFCYKCKFYGIESHRC
IQLSVSNHWCWNACTHCWRLRPQDVGLEWNETVMPYNDDPKFIMDNAIKEYRRIMSGYKG
RPGTDLKMYEEAMNPKHVAISLTGEPTLYPRLGELIKEIHNRGMSSFLVTRGIRPDVLGN
LEEEPSQIYISLEAWDKESYNLFNKPLVPRGWELTLETLEMLPSFSSTTVYRITLVKGFN
DTDEAVKGFARLIKLGMPSYIEVKAFMYVGASKIRLTKDNMPSYNYVKEIANKISEESGY
PMVSESIPSRIVLLSNLEKPVRYGNGCPMGWSHKEDNKPGEYEVCDEDCS
>A0A518SAJ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salarchaeum sp. JOR-1|TrEMBL
MSESDAPKQVSSPEYHSENHTAAQTCGWTANSLRGEGTCYKYAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHAGHTYELDGVEWDDPEAVVDASIRLQKKLLSGFGGNDEVPRERFEEAM
DPQHVAISLDGEPTLYPHLPELVEAFHDRGMTTFLVSNGTRPDVLRECEPTQLYVSVDAP
ERATFEDVVGAMEEDAWEKLVETLDVLSEKDCRTTLRTTLVNGENMQNPDWYAGLYERAD
PDFVELKAYMHVGHSRGRLDRSAMPRHEDVLDFAREVQSHLPEHSVLKDQEQSSVALLAR
EADTWVEALKHPS
>A0A7K9M5B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oceanodroma tethys|TrEMBL
LDISMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIIIQFTTTKTKKKGEKSNGNPASSE
EDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVISMGDYDP
DDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKMYLKGLRYAVFG
LGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKVKFLS
RLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHERGTSEYENPEAEELFETSSEEEAD
AEEAGGTNSVIDVEDLGNVMSHMKKAKEGDLGTSLTRENAGRKEEGEKREMVTPALREAL
TKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKAGRFEEAMTAKHCALSL
VGEPIMYPEINRFVKLLHQHSISTFLVTNAQFPDEIRNLEPVTQLYVSVDASTKERLKRI
DRPLFKDFWQRFLDSLKALSEK
>A0A8C8YY72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prolemur simus|TrEMBL
LDPSLDMWDLSSSLISLWINRFYIYMGLAFGISLWICVQIVIKKQDRNSQEKSVPKTTLD
LMTNGYVSLEKKEIFVSGVKIFYGSQTGTAKGFATILAEAVTSLDLPVAIINLKEYDPDD
HLVEEVTSKNVCIFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYAVFGLG
NSAYASYFNKVGKNVDKWLWMLGAHRVMTRGEGDCDVGRSKHGSIEADFRVWKTKFIYQL
QALCKGGKKKSCGGNCKKGKCESNQHGSEETEPRPHTPDELHPRDTEEEEPCESSSEEEF
GTEDRQGLNSVVDVEDLGKIMDRVKKEKKEKEQQEEKTSLFRNTGKNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVQAGRFEEGMAVKHC
ALSLVGEPIMYPEINRFLKLLHHCKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMANVPWHEEVVRFVRELAELIPDYEIACEHEHSNCLLIAHKKF
KVDGEWWTWIDYSRFQELVQEYEDSGGSKTFGAKDYMSKTPHWALFGASERGFDPKDTRY
QRKNRSKDISGC
>A0A177A5Y9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus destructans|TrEMBL
MANNEYFGADIASHATENYFMALWHTYRIPLILTLLALLLITRAVLHLKFGREKIIYTPP
PTPSEKTHVAANPQREQLVEKAPIPAEVKKAGPKRVVGKVTRKKSLLRDQPASKDVRFQV
LVFYSTLAGSTERTAQTLTTKLADTLKANAESSQYEFLSPIAHDLAELEDYDEYFLGLPK
PEDASQDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEDAEEDDVEVQSDGAVKLKRKSKKKVTSSMDDVEDIGRI
LQKGQTESEDQDEDEGAVDFTTYGKKNPKPSAAPKEMVPKGSPTYNALTKQGYIIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVIDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLNE
FTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWQRF
QRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTPSS
GAAGLTMQNVPFYEEVCAFVLALTAALDKRGLKYGIAAEHAHSCCILIASDRFKKEGKWH
TRIDYAKFFERLESGEPFTPEDYMGPETPEWATWGNGGFDPRDERVYRRGKNKVPLRVVG
EEGEEGEEGQKEEKPKLVEI
>A0A8C0U0I5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyanistes caeruleus|TrEMBL
MSFQPLGNTWILRNTWILRNTWILCSWLISVKTRCKLQMTVGGCELCSSVRICDIPDLDV
SMDAWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRIKRKGEKSHGNPSAPEGA
ADKLGNGCATPQAQEIHVAGVKIFYGSQTGTAKRFAKALAEAVMSLNLPVEVINMGDYDP
EDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAGSDFRVGKSFLQGLRYAVFG
LGNSAYVDHYNTVGRRMDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLT
RLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEPGTSEHEDTEAEELFESSGEEEAG
GTDSVIDVEDLGTIMGHMKKAKRERELEAGAAGAWRKEEAERREMITPALREALTKQGYK
LIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNP
VGTEWRWKMDQPEVILQEAMEKHQNMIRQFKGVSGVKAALLEEALAVKHCALSLVGEPIM
YPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPLFK
DFWQRFLDSLKALAEKQQRTVYRLTLVKGWNVDELKAYADLISLGKPDFVEVKGVTYCGE
SPASSLSMANVPWHGEVLSFVQELARLLPEYGIACEHEHSNCLLLAHCKFQVDGEWRTWI
DYGRFQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPSHVRFQRKNKAGDSS
GC
>A0A6J3M1R6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dissoconium aciculare CBS 342.82|TrEMBL
MNLNQLHELPQELLYIWHAHRTGILLAAGILFAIVRLGLHWRSNRIDKYVLKHEIIDKTS
DDTPRRSVVAQPEITPVNTQETTQTTNATRTKEPRRVQGNKSRKQTPNQDGDVLEHLQIY
IFYFTLGGSTKAYAERLAANLNGASATNQKILPVEVHDLAEVDYDDYFITPPKSAQRSTA
SVYLILLPSYNIDTELSNFLSHMEDTHNDFRIDTGSLSTLAGYSVFGFGDRQEWPTEAQG
YCTQAVEVDKWMAKLTRRKRAFPLGTGDIRKDVDQRLQEWQSGVEGILADLADGKGLGEG
VSGSGDAVESGDEDDTEEPLASDSKPRRKVRSDAGDLEDIKVPIPVDFTSLGRSAATTNA
PKAMVPKSSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHLCME
ATPSLSCSNKCVFCWRHGTNPVGTTWRWEVDEPDLVFEGMKAGHYSKIKMMRGVPGVRSE
RFAEAMRIRHCALSLVGEPIFYPHINALLAMLHAEHISSFLVCNAQHPDQLAALGPVTQL
YVSIDASNKESLRKIDRPLHRDFWERFIRCMDILREKRFTHRTVFRLTLVKGFNIDDEAS
GYADLVERALPGFIEVKGVTYCGTSTAAGAGLSMQNVPFYEEVSAFVLALEKELLRRGLD
YGIGAEHAHSCCILLADRKRFFRGRWHTLIDYEKFFQCVESKKPFSPEDYIGEATPEWAA
WGKGGFDPRDVRVDRKGKPKVVEI
>A0A7S2T660|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chloropicon primus|TrEMBL
KRESTAMAESEDIDGGNGGLFARIVSLWRKLLKLIKSIFKDEKWLSNLTLGLGLPTLSQL
VRGQGGGVVTSGKVFYGTQKGTSKRLAERLVHLAKKKFGLDLEAVNMADYEVEKLPTERG
LVFFVISTYTDGTPPEPAQWFYRWVEESAHDFRCGADFLKELKFAVFGCGNSQYVENFNK
CAKTLSGNLKLMGAKEVADVFLGDEDKGSLDTQFRDWTGILQLRLADYCKPLETLQLEKP
RNPSVKAKLEKIRKQKEKDGGQSTDIEDIGKALNGLKAGEKPEMLNHTTRGNLKKQGYKI
IGTHSGVKLCRWTKSMLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPI
GKEWKWKMDPPDKIVSEAIACHRGMIKEMKGVPGVKPERLAEGIDVKHCALSLVGEPIMY
PEINELCNRLHGEGISTFLVTNAQFPRAIERLVPVTQLYVSVDAGNKESLKAIDRPLFSD
FWERFLLCLQKLRDKRQRTVYRLTLVNDWNVSEVEQYASLVDIGKPDFIEIKGVTYCGSN
DASSLTMKNVPYHNEVRAFGEKLCSLRNEEYGLACEHEHSLSILLARKDRYLKGRKWHTW
IDYEKFQSLYRSGKPFGAEDYMEETPSWAVWGAEEKGFDPQETRFRKKRNHPGKNVSVDS
DTKQAIKTT
>A0A5N6PCY7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mikania micrantha|TrEMBL
MFTTTTTHLTVLALLSAATVYCFYKSHRLRRLKVSSPSSNPNHSIATRRGKLFFISQTGT
SKTLAQRLFGLLISNNIPFDLVDPNNYEPEDLHTETLVLIIASTWEDGNPPSNGVFLSKW
LSESAEDFRVGSLLLNKCKFAVFGVGSRAYGDSFNAVGRGFSRKMRSLGGVEILPLREGD
VDEGDIDKEFGVWSEEVIRVLKMGELRGNGSAFTGENGGELMNGSDYDEDDDDDYEDEGN
GLESDIIDLEDIAGKSLSKKDMGLITNNGKKNGEKVMVTPVIRASLTKQGYKIIGSHSGV
KICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWK
MDDPLMIVNSAIEQHTKMIKQMKGVPGVTAERLSEGLLPRHCALSLVGEPIMYPEINSLI
DELHKRRISTFLVTNAQFPDKIVSLKPITQLYVSVDAATKDSMKAIDRPLFGDFWERFVD
SLKALKDKQQRTVYRLTLVKGWNTEDVDAYSNLFSIGNPDFVEIKGVTYCGTSATSKLTM
ENVPWHADVKAFSEALAEKSHGQYEVACEHVHSCCVLLAKVDKFKINGQWHTWIDYEKFH
DLVSSGKPFGSNDYMALTPSWAVYGANEGGFDPEQARYKKERNHKSSR
>A0A832RJY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp|TrEMBL
MIISDEQRKNLEKKGYRFAGNFGHAGNKICHWTRKSIVDDGVCYKEQFYGIKSHRCLQMS
PAIPYCQHKCLFCWRDTDITKTSWDSDDYDDPRTIIEDCIANQRQLLCGYFGNDNANPVK
LEECLVPNNAAMSLAGEPLLYPEINQLIHEFKRLDFTTFLVSNGENPERIAALEEEEPTQ
LYVSLDAPDEETYKRTCLPQVSDGWQKLNESLELLSTLDTRKVLRITSVNDLNMNNPEEY
AKIISKCDIDYVEIKAYMFVGDSRERLEWENMPKSVDIREFANSVAEHAGLDVIDEVEKS
RVLLLGDKKPVKYNK
>A0A1Y2XEW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daldinia sp. EC12|TrEMBL
MTSEIGGLSSNDTGSLQGILEVWHDHRPAILFATTGILAVLWLYIELRQKPKVPTNTVKF
DQHLPNPATSNDSKALEEKIDLQKEKPKEPTTGPRRIKGELRRTDSARKHEESTTPVQTL
VFYSSLTGSTEKTASEIAQILGTSLREKAEGSGKSFLNPLVLDLAEVDYDEYFISPPKPA
DSNTPIDYFYLLLVPSYNIDSINDNFLEHLSETHHDFRIDTAPLSGLLGYSVFGLGDREG
WPTEDEGFCFQAKEVDKWMARLTSRKRAYPLGMADTKRDLRERLSEWTVGVVDILKHIAV
TGSLGEGVPGSGNDVESEDEYGSGDDDGEVEIDQTASTNKPKKGRSGNIDDVEDLGKIMR
TSRSDAELPSSPAPIAVDFTTYNKPKSKRPPQTVKEMVPKNSPTYASLTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPEMIFNGVKDGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINE
FLALLHGERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERF
QRCLDILREKRFRQRTVFRLTLVKGFNVEDEVEGYADLIERGLPCFVEIKGVTYCGTSSS
AGAGLSMANVPFYAEVTEFVTALDNKLRERGLKYGIAAEHAHSCCVLIASERFRVDGKWH
TRIDYQRFFELLEERGADGDWTPEEYMGPETPEWATWGNGGFDPRDVRVDRKGRKIEVS
>A0A830FF48|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halocalculus aciditolerans|TrEMBL
MPQQVDSPNYHHEGHTAAQTCGWTANALRGEGTCYKHAWYGIRSHQCIQMTPVVRCNERC
VFCWRDHNGHAYELDGVEWDDPEAVVDASIELQKKLLSGFGGNDEVPRERFEEAMEPRHV
AISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEVLRECDPTQLYVSVDAPERATF
DDVVGAMEDDAWENLVETMDVLHGKEETRTVLRTTLVEGENMRNPDWYAGFYERADPDFV
EMKGYMHVGHSRGRLSRESMPSPERVDEFASDVQEYMDGFDHRFTQEASRVSLLSKTEDT
WVPKLRPDSEFWA
>A0A081RLY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote SCGC AAA799-N04|TrEMBL
MSCSGEVVEGEEQLIQIKPAISEQLKKAKYGVSNHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLNSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFVKINKPKYDDSWERWNRTLGMLKHLDTRTVL
RITLIRGYNDQTDMIPAFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMQEVKRFS
EQVAKQSQIFSVMDESFVSRISILQNNERFIDRWIPAYANTN
>A5ULP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)|TrEMBL
MSLNKKQVEKLESSGYRFVGSHNHAAAKICHWTKQSILDKGVCYKEKFYGIESHRCLQMA
PAVPNCQQKCEFCWRDLSYTQTQWEGEYDDPKTIIDEAVKAQNNLLCGFFGNDKANKEKL
EESKTPTNAAISLAGEPMLYPEIDELIAEFNRRNFTTFVVSNGQCVDKLKNLENEPYQLY
LSLDAPTKKIYNDVCRPQISEGWDNLNQSLDTLASFNSRTCIRTTCVKGRNMTNPEKYAE
LIKKASPDFVEIKAYMCVGSSRHRLTPDNMPTFDEVKSFAQKIGENCGKKIVNESEVSRV
VLLQ
>D2ZPV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter smithii DSM 2374|TrEMBL
MSLNKKQVEKLESSGYRFVGSHNHAAAKICHWTKQSILDKGVCYKEKFYGIESHRCLQMA
PAVPNCQQKCEFCWRDLSYTQTQWEGEYDDPKTIIDEAVKAQNNLLCGFFGNDKANKEKL
EESKTPTNAAISLAGEPMLYPEIDELIAEFNRRNFTTFVVSNGQCVDKLKNLENEPYQLY
LSLDAPTKKIYNDVCQPQISEGWDNLNQSLDTLASFNSRTCIRTTCVKGRNMTNPEKYAE
LIKKANPDFVEIKAYMCVGSSRHRLTPDNMPTFDEVKSFAQKIGENCGKKIVNESEVSRV
VLLQ
>A0A7J9NG25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVKKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYLDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLERGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A455BYP4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Physeter macrocephalus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKQVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVCAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVAKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHECKISSFLVTNAQFPAEIRSLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKR
>A0A2H9LHL9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon CG07_land_8_20_14_0_80_44_23|TrEMBL
MVKEQLRKALEKQNYAVFGRHSAVKICAWTKKALRDEDFCYKQKFYGIRSHLCCQMTPAL
DYCPNSCRFCWRAIELTSGAEIPESEVDEPEDILSGSIAAQRKLLSGFPGNPKANQKKVK
EAMEPMHFAISLAGEPASYPKLDALIELLHKNGKTTFLVTNGQFPEKISSLKHLPTQLYI
SLTAPDEETYRRTAVPTFKDAWQRLNSSLEIMAGLAGKTRTTIRMTLVKGLNMHSPEKYA
ELIKKANPLFVEAKAYMYVGFSRERLKMENMPSHAEVREFAEKTGKHCGYHIVDEKQNSR
VVLLMQKDFPGRIMKFG
>A0A6Q2Z6M7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
MFLKHLSIFTLPQTIALETKAKMLQGSTLLLLDFITDILCADIDGKKTVRSTLESYILLV
WQNRLYLYTAAAVFVGIWFSMKIALKKKILTTPVNPWLYKSVKQNVYSVENVNVVHVSEV
KIFYGSQTGTAKGFANELEEEVKTLGIAAKVIDMKDYDPDDRLADECSTKSICVFLLATY
TDGQPTENAKWFCKWLEEASTDFRYGNNYLKGLRYAVFGLGNSVYDSHFNTVSKNVDKWL
WKLSGVRVLSRGDGDCNVVKSRHGSLHSDFLVWKTKFLSRLQTMVAGPKACRGKCKTGGS
CNNRKKPQKTDDEQAAPEQLSSEEELVESSSEEEAAGTGPDEQHPGSVIDVEDLGNMMNG
MRKAKRRVEGQVDEQMKLPRLNRQKKAEEEEERREMITPALRVALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPPEKILLEAVENHQNMIRQFRGVPGVRLERYQEGLKVKHCALSLVGEPIMYPEINAFLC
LLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWTRFLDS
LKALGEKRQRTVYRLTLVKAWNVDELKSYSELISLGQPDFIEVKGVTYCGESSASSLTMA
NVPWHEEVIHFVQQLVDMLPQYQIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELV
QAYEESGGSQTFSAMDYMAKTPMWALFGASERGFDPTDTRYQRRHKTKDISGC
>D5U0X4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermosphaera aggregans (strain DSM 11486 / M11TL)|TrEMBL
MSINYHEVKKKREEFWNSSLVYKAIYDRLVRQGYHLIGTIGAVKRCHWTKEAVLRKRFCY
KCLWYGIESHRCIQMTPVVAWCWNRCLHCWRIQPEDVGMHWDDTRPPVIDDPEVLVEESI
RVHREIMAGYKGNPLADQSMVDEAMNPKHAAISLTGEPLLYPRLSELIEEYHKRGLTTFL
VTHGTRPDVLKSLVKEPSQLYISIESWDKEMYEYFNRPLVPRAWELFQETLELIRSFKSP
TVFRFTIVKGYNDHEKALESFAKFVEKAQPTYVEVKAYMFLGGSRGRLEHSNMPSHEDIR
RVGRILSEKTGYKLLSESIPSRIVLLSRIDKPIRHGKGCPDGVEHPEKYAPAFSKEYEEL
TD
>A0A1C6YPR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium chabaudi chabaudi|TrEMBL
MVTKREDELVLPPNEGGNINTYSIQKKTKINLTIIYGSEGITSYKAAKEFLNELIYFFNN
ILSHFNTISTITKGDNKNNTIFEGSISNEINNIEDYMLEYFRSKLLKTNKKNKDGKFVKK
CKNEKTNNESSKCDNEVKDIFDNLKKYEKNIIKCGNTHFNNYLNCSIENNISEIHFDFVN
GNEFDSYTFFENSENNDLNILFMFISTYNFGAFPTNCYKLEDILTDLVNDFRVEKNYLKN
IFYSCVGFGNKEYGSKYFCTPIKKCDKFLSSLGANKLEKTLTLCSTMDNDEEFIHWKSSL
LKKICLSLFLYNFNYTKFSNNFFHYANRKNYNTLKYYCTYFCKKSEPINDDEKQASKSVD
NNNIHKCDCIRNGVSSEHLDAAKESGDNHNKLTNKINGHISFSTSKMDANNTEKCGCTSS
NCVNGNDKYINEKEVINNNFETSIVNGCCKNEYEQDGELINSDFSNESMNENNDEINCNS
SEDLEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKAQIRGRGGCYKHTFY
GINSYQCMEATPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVDEAVKKHKNMIKEL
KGVHNIINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFLVTNAQFPNEL
KKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKERKERTVFRFTLVKEY
NMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLVNSK
RSISDIYEISCEHKHSCSILIAKKVFKINNKWHTWINYEKFQSLVKQNVNFSAIDYCAET
PEWAVVGAPECGFNPSDQRVYTKGKNKNKNNINTMEVKT
>A0A4Y1QSY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus dulcis|TrEMBL
MNHSGEFPERTKPEISFPAMSLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNP
SSSPRKGKLFFISQTGTSKALAHRLLDLLTSNGLAFDLVDPNHYEPEDLPKETLVLIIAS
TWDDGKPPANAKFFSNWLAESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAK
RMRALGASEIFSIWEGDVDGGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNAVGAECEAE
SFDGSDEDEEEEDDVESEVVDLEDIAGKGPSRRRTVTVTKTNGTVNGQKEMVTPVIRASL
VKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGKSWQWKMDDPLEIVNSAIDLHTKMIKQMKGVPGVTLERLTEGLSPRHCALSL
VGEPIMYPEINALVDELHRRRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAI
DRPLFGDFWERFIDSLKSLKEKQQRTVYRLTLVKGWNTEDIDAYYNIFSIGNPDFVEIKG
VTYCGSSATSKLTMENVPWHADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTDKFKI
NGQWFTWIDYEKFHDLVSSRRPFDSKDYMAATPSWAVYGAEEGGFDPYQSRYKKERHHRS
NQ
>A0A2R6KTH9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_6_65_46|TrEMBL
MSDSGPKQVDDPEYHSRNHTAAQTCGWTASALRGEGRCYKNRFYGIQSHRCIQMTPVVKC
NERCVFCWRDHAGHAYELDEVEWDDPEAVVDASIDLQRTLLSGFGGNDQVPSGMFEEAME
PRHVAISLDGEPTLYPYLPELIEAFHDRGITTFLVSNGTRPEVLRACDPTQLYVSVDAAD
RHTFHETVAATEDDAWERLLDTLDVLAEKEETRTVIRTTLVDGFNMHTPEWYAVMCERAD
IDFLEMKAYMYVGHSRSRLGHEHMPSHDEVRAFTERVGSFLPDHDTLREVADSRVTLLAR
DEDTWVPKLKGDSEFWA
>A0A6A5SX50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Clathrospora elynae|TrEMBL
MAFLHISEQLPAELLLIWHHHRLPILLCALAAATIVRLVLYSRSRRHKIFASPTPSSPVE
KKTVELKPEWLPAYTTTLSPPNSNTDNHAEDDISAVALVAKAKKGPKTVKGRKTTKKSAV
PAPIFDHKTDKIQPLVFFQSLSGTTERYAVQFAKVFGEWTAECEQASSFLEPQTLDISYI
EHDDYFISPPKTDAGTKYFYIILIPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLGY
SVFGFGEKEGWPTEEQGFCSQAREVDKWMARLTGRKRAYPLGMADVKNDVEDRLQEWRIG
VQEALVEIAEGRGLGEGVAGSGDPAESDEEDIEDAEDSNGQGTRVDDVEDLGSMVTSSST
PIPVDFTTYKSKPKPKLISTPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSALR
GRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDGI
TAAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLEIMHSNRISTF
LVCNAQHPAQLASLVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACLDILRNRRFE
QRTVFRLTLVKGFNMAEEVKGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPFY
EEVAEFVTELEKELNSRGLTYGIGAEHAHSCCVLLADRTRFMKKGKWATRIDFERFFDLY
EGKAQGTREDNGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKMETEGED
KKEQAESKRADSAALEF
>A0A6P6UVE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coffea arabica|TrEMBL
MFPSLSPTRLTLLTLLSATTLFLFYKSHRRLLHRLKTFKTLNPDTRGKIFFISQTSTSKG
LAQRLHNLLTLNNLPFDLIDPKDYEPEDLCRETLVLVIASTWENGEPPQNGAFLVNWVNE
SAEDFRVGAALLVKCKFAVFGVGSRAYGETFNAVGKGLSGNLRKLGAKELLEICEGDVDG
GDLDKVFDGWSKKVVEALKDNWKENGVYFGNLNGVDGEASDEEEYDDEDDEEGENDGESE
LVDLEDIAGKGPSRRKEMVEAKANGELNGVTGKKAMVTPVIRANLEKQGYKVIGSHSGVK
LCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKM
DDPLEIVNTAIELHTKMIRQMKGVPGVKEGRLSEGLAPRHCALSLVGEPIMYPEINTLVD
ELHRRRISTFLVTNAQFPEKIKLLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFVES
LKALKDKQQRTVYRLTLVKGWNTEDVDAYSSLFGTGNPDFIEIKGVTYCGSSATSKLTME
NVPWHYDVKEFSEALCRRSNGEYEVACEHVHSCCVLLAKVEKFKVDGQWYTWIDYEKFHD
LVASGKSFTSKDYMAPTPSWAVYGAEEGGFDPEQTRYKKERHHKNSR
>A0A3M7I6X5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hortaea werneckii|TrEMBL
MDIDKILQLPEELLFLWHAHRAEVLLSAGLLFALLRLAVHWRTRKSKEVLTPPVLTPVDE
KPLAVPSAKETLADADHYEAPTPKPTVQRPKPGPKRVTGTKKSKSAASQEAQVIEKVQPI
IFYYTLGGSTKVYAESVAQDLATSSPSSLLEPQLHDLADTEYDDFFLSIPKAEKTAHFYL
LLLPTYNIDTNLSNFLEHLQETHHDFRIDTAPLSGLAGYSVFGLGDKHEWPSEAEGFCTQ
AVDADKWMARLTGRKRGFPLGFGDVSKKDESDNMLREWTKGVSSIMKDLAEGKGLGEGVP
GSGEPIESADEASEDEDETAAPRKPKRKSANRSKTDDLEDLKAPIPVDFTTSKPTSTTQP
PPPKPMVPETSPTYSALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIQSHLC
MEATPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPEPVFQGMKEGHYKKIKMMRGVPGVR
AERFQEAMRIRHCALSLVGEPIFYPYINELLGMLHRERISSFLVCNAQHPDQLEALGPVT
QLYVSIDASNKEMLRQIDRPLHRDYWERFLRCMEILGRKRFTHRTVFRLTLVKGFNIEEE
AEGYANLVETARPGFVEVKGVTYCGTSTSKGAGLSMQNVPFYQEVTAFVLALEKALAKRG
LDYGIGAEHAHSCCILLADRGRFFRVPAAEKDNPAAKRKWHTLIDYPRFFDCLESGKDFA
PEDYVGPPTPEWALWGHGGFDPRDERVDRKGRPKEPKVQEVQEVQEVQK
>A0A0K8SHK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lygus hesperus|TrEMBL
MMLEFLLSINFLGHFLIASVIALLIFKNFCNLYSAETSEPILPTAKRQQKENERQRPQSL
YRNIDTNFRCIEVYFATEYGNTKKLCEKLVEYFTTTKSIDSVLIDLSNIEPEDVLHSKNA
QRKCLSLFVLPTVTDGQPPKAAKWFCKWLSDAATDFRIDKQSQAHVSYAVFGLGNSVYAE
NFNIVAKEVDENLAQLGACRVCKLTLGDEDTSESQNGGLEADFDAWTKVIENVVWSQCTP
PYEVLDTRANEVETSSEEEDVVDIEDLVKPKSKRTNSKSEGAKEMITPQLRGVLTKQGYK
LIGFHSGVKLCRWTKSMMRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNP
VGTEWKWKMDDANTILRGALENHYNMIKEFKGVPGVLPEKFAEALAVKHCALSLVGEPIM
YPEINKFCRLLHEEGISTFLVTNAQFPEAIRAMDPVTQLYVSVDASTKESLKKIDRPLFK
DFWERFIDSLKALSEKTVQP
>A0A0E3RPE1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina mazei S-6|TrEMBL
MPLEEKKKEQENFGENLPEVQEENTGEEQTSLPFDIPDFATLLKKQGYALAGRHSAVKTC
LWLRKAMNDEGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPGEWDFPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNQPNNVAISLSGEPTFYPYLPELIEEYEK
RGFTTFLVTNGTVPSMLAKVNPSQLYMSLDAPDLETYLRICQPKSPALWDRINESLDIMK
DKSSRTVIRTTLVKGENIFNPEGYAEMIKKASPDFVEIKAYMHLGFSRLRLERSAMPSHE
EVLEFSKELAKHLGYEIADESEISRVVLLSKDGRKSPVKKK
>A0A1Q7NAC0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_2_39_13_1|TrEMBL
MSCSGETVEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFKNGGDCYKHKFY
GISTHKCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVGNLMEERRRLIM
GHYGDERNDKSKLDESLLPSHYAISLSGEPTMYPQLPELIKYLKKLITTKSVFLVTNGQE
PDMLQRLQDEDALPTQLYLSTNAPNEEIFHSVNRPKYKDAWERWNTSLEILSKLDTRTVL
RITLIRNYNCDDELIAEYVKMIKRSNVHFIETKSYMHIGRSTNRLERSDMLEMPEVRHFS
SELAKQTQIFSVMDESEISRIVVLQNRRRIIDRWIASYANTN
>A0A1Q3ACQ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces rouxii|TrEMBL
MRSNPVTAVATALCTGAYLWFGGRISVALAILVFYGIWHEESNKIVEEKPQLPSDGVEGK
KKEKHTCCGGKGGSSCCSSKNGKSGSGHACRCGSQKNKPAEEEKQDADSYPVAVDFTQAF
KPQKKKKSRQPKVFSKSMPVKKQNEVPKQDNLVKSAMTVSNETLLNSQIYIFYCTLQGAA
ERCANKVMAKLCTMKELRHRPILVNLDEITDIDDYFVNVPCDNALYLMVLPSYDTDCPLD
FFLQTLEENFNDFRIDKYPLRKLVGYSILGIGDSESWPERFCYQAKKADHWVARLGGRRV
FPVGEICMKYDGENKVEEWTDLFAETLKDDEPILYEYDESVEENDNADGGEEMVDLEDIG
NADGNNSAEIKQMVAKNSPTYKTLTKQGYSVVGSHSGVKICRWTKNDLRGRGSCYKHSLF
NIVSSRCMELTPSLACSSKCVFCWRHGSNPVSKNWRWEVDDPEYILENALKSHYSKIKQM
RGVPGVKAERFAKAFQVRHCALSLVGEPIMYPYISKFISLLHAKGISSFLVCNAQHPEAL
AMICKVTQLYVSIDASTKSELKRIDRPLYKDFWERLMQCLDILSTTQSHQRTVFRLTLVK
GFNMAEVMSYADLVQRGRPCFIEIKGATFAGSSDGNGNPLTMQNIPFYEEIKTFVRNFAA
ELQRRGLGYDISAEHAHSNCVLIASTKFKIDGEWYTHIDFDKFFELLESGKDFQPLDYIA
KTPEWALFGNGGFAPGDTRFYRKGKKRSPEQSESTTQQQTVETAGSIEIA
>A0A6S6VNI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora teres f. maculata|TrEMBL
MVFLQYAEQLPTELLLIWREHRLEILLSALVVATIARLVIYSRDRKREKVSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLLNVDNHAEDDAAAVRIVSKAKKGPKTVKGRKIQKKNI
VPVSTFDHKADKIQLLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQTLDISY
IEHDDYFISPPKADANIKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIGTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GIQEALIEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSMVNSSS
APIPVDFTTYKKAAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINDLLSIMHNHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNTRGLQYGIGAEHAHSCCVLLADKTRFQKNGRWATRIDFERFFD
LWEGKVKGTRVEGGEVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKTEEKI
EGEGERESKVERAKALEF
>A0A6G1K7Q5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pleomassaria siparia CBS 279.74|TrEMBL
MASSGLLAQLPTELLYLWHTYRVPILLTAVSVFAVVRLALHQRRKRERISTSPLPSSPIE
KKAVQLRPEWLPENTTLNHSVLSLDNHAEEPTTVAVPLEKARKGPKTVKGNKMRSKVAKI
APTFDHTVDQIQPIIFFQSLSGTTERYATEFAKAFTTWNSEASSSLLEPQILDISYIEFD
DYFISPPKSESNIKHFYIILIPTYNIDTVLSIFLESLQETHNDFRIDTAPLNALLGYSVF
GFGDKQDWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGGASLRLDEWREGVQE
ALVEIKEGHGLGEGVPGSGDAAESDEEDISDAENMDSEVTSRKPVRTRKTARVDDVEDLG
SMVDSSNPNSLIPIDFTTYKSQAKPASRQAPKEMVPVTSPTHASLTKQGYSIIGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWIT
DAPDLIFDGITAAHYKKIKMLKGVPGVKAERFAEAMRIRHCALSLVGEPIFYPHINELVE
IMHKNRISTFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCAC
LDIIKNRRFEQRTVFRLTLVKGFNMAEEVKGYADLVERALPGFVEVKGVTFCGTSAAGTA
GLTMQNVPFYEEVAEFVTELEKELSTRGLTYGIGAEHAHSCCILLADSTRFQRNGKWATR
IDFERFFDLYEGKVEGTRVEKGEDGMEKVIGWRPEDYVGGETPEWALWGNGGFDPRDARV
YRKGKGPGGQAEAYAKSEAAKLVEI
>A0A1S3KHL1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lingula unguis|TrEMBL
MDEGTFLADLAAVISQSWLLILLGFLGLAWLTFQQRKSVVPGKPKRRLSDQASKNSDERN
LNKAKSSKKETCLKIFFGTQTGTAKTFADIIKKEASEHSTKCEVIDLKTYDPEDNITDET
DGKNICVFIISTYTEGSPPDDAAWFYKWLEEAASDFRIQKTMLQDMRYCVVGLGNSLYKE
RYNKVARNIDHWFHKLSANRVLGIGLLDENVASSKNGGIEADFEFWKNRFWSMVLGSPQN
KKDVKPNCGTADGDTKEMYETSSEEDTEDEEEEGDGDGEKVQKANGVVDVEDIGKMVNNI
KKAKAKRKVEDDNKSKEPREMITPLLRTSLQKQGYRLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDDPELILEGALQNHC
NMIKQFKGVPGVKSDRFTEGLTPKHCALSLVGEPIMYPEINKFAEMLHSKGISSFLVTNA
QFPDAIRNLTPVTQLYVSVDASTKESLKKIDRPLFRDYWERFLDSLKALSEKGQRTVYRL
TLVKNYNTEDIENYASLVSIGKPDFIEIKGVTYCGESKASRLTMDNVPWHEEVIKFVQDV
VDRLPDYAIASEHEHSNCVLVAHKKFQVNGDWWTWIDYDRFHELVQMYKASEGQKTFSAA
DYMAQTPHWAVFGADERGFDPGETRFMRKKTKDISGC
>A0A2I0D1N0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregula sp|TrEMBL
MPSDPCEPLRKQGYQFFSKSSTAALKPCMWCKRALAGGDMCYKHQFYGIDSHRCVQLTPT
LRCNQRCLFCWRSFEHEPAEADECPPETILAGIHRFQKKALAGYNAVLDNTVTEERWKEA
LDPKHVAISLSGEPTLYSRLPELIDLFNSKGYTTFVVSNGTNPEMLKRCNPFQMYVSLDA
PDKETYERVCRPMGDYWERVQESLRLLGSRRSAVRITLVKGLNDIAPERYAAILQESGAR
FVEIKGYMYLGYSRNRLVRENMPDHAYVRAFAEKVAAACDYRYKDENELSRVVVLERKT
>A0A2R6L5U8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_12_69_24|TrEMBL
MPKQVSDPDYHSENHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELDGVEWDDPEAVVDASIDLQRNLLSGFGGNDDVPREVFEEAMEPRHV
AISLDGEPTLYPYLPELIEAFHDREITTFLVSNGTRPEVLADCNPTQLYVSVDAPDRKTF
GEVVKALEDDAWDRLVETLDVLAAKDDTRTVLRTTLLAGYNMSHPEWYAAMFDRADADFV
EMKAFMHVGNSRDRLDRNVMPDHADVVAFTEAVGGYLPTHPVLRDVEVSRVALLAREEDT
WVPELKGGSEFWERTPYASS
>A0A327H110|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon TMED132|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKILEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNTRAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSAENMPRHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GQEISPMPIPKATMFFPEDLGIAPSVKHLPIIQ
>A0A0A0LPA4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cucumis sativus|TrEMBL
MSLSSRSAKLTILALLSASTLYCFYKSRRLRKLKLSLNPTLPSRKPKLFFISQTGTSKAL
AHRLLNVLNSNGLVFDLVDPKDYEPEDLFKETLVLFVASTWEDGGPPPHAKFLANWLSES
AEDFRVGSLLLSQCKFSVFGVGSRVYGETFNAVARDFSKRLKALGAKEILPIGEGDVDGG
DIDKCFDDWSRKLLKVMKFDAEGNGVELCSGIAGDSDAVSVEEDEEEDDDLGEEDIVDLE
DIAGKGPSRKSTNIVETNGKLNGKKVMVTPVIRASLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWEMDDPLEIVNS
AIDLHTKMIKQMKGVPGVTQEKLEEGLSPRHCALSLVGEPIMYPEINTLVDELHRRRIST
FLVTNAQFPDKIKLLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKALNEKQQ
RTVYRLTLVKGWNTEDIDAYSNLFSIGRPDFVEIKGVTYCGSSTTSKLTMENVPWHSDVK
SFSEALAAKSQGEYEVACEHVHSCCVLLAKTDKFRVDGQWFTWIDYDKFHDLVASGKPFD
SKDYMAPTPSWAVYGSDEGGFDPDQSRYRKERHHKPKPTS
>A0A084B1T4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stachybotrys chartarum (strain CBS 109288 / IBT 7711)|TrEMBL
MDTLWPNHPQADGQVNGVLAIWHTYRTQIILLALVILFGARVILHTKEQRQDLIVLPRVY
EKEVLIPRSSESENAKVNSTKEAKTRGPRRIKGGLVKRPSDDDNAKQTEQRIKTLIFFSS
ITTKTEKFAHAYLESLQSDLKQLAEKTGKVFLEPEVRDLTDIDFDDYFVSPPKLGDDVAL
LYLFLIPSYNIDTINDTFLQHLEETHHDFRIDTGSLASLLGYSVFGYGDKEGWPDEAEGF
CFQAKEIDRWMAKLTGRKRAYPVGMGDMKSDHTERFNEWATGVLEIMEHTARTGNLGEGL
PGSGDAEESDIEDEGDIDDGEVLVEEDTLGDNEKIQSRTLEDVEDLGRTIHPSNGGKRSN
GPVAVDFTTYSAAEKKKAQTNVVKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFE
GVKDNHYKKIKMMRGMPGVRAERYNEAMKIRHCALSLVGEPIFYPYINEFLGMLHAERIS
SFLVCNAQHPEQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREKR
FRHRTVYRLTLVKGFNVDDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSTNAGLTMTNVP
FYWEVCDFVRALEKRLQDKGLNYGIAAEHAHSCCILLASERFNVDGKWHTHIDYQKFFEL
LEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDDRVDRKGRKIEPVVIRDRPQVSEIV
>A0A835I557|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coptis chinensis|TrEMBL
MTSISSSIIKTTLLTLLSFTSLYCFYKSHHLKKKSPSISQNPNPKTNKIFYISQTGTSKT
LANRLLELFNLNANHFNFDIVDIKDYEPEDLLKETLVLFVVSTWDDGMCPQTCRFFENWL
NESAEDFRVGSLILSQCRFGVFGVGSKGYGESYNAVGKEFAKRLRALGAREILGLGEGDV
DSGDLEQVFEVWSEKLVRVLKGGGEGNEVVGDGGGLGYKIIGSHSGVKICRWTKSQLRGR
GGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVAKSWQWKMDDPLEIVNAAID
QHTKMIKQMKGVPGVKAESLLEGMSPRHCALSLVGEPIMYPEINTLVDELHSRRISTFLV
TNAQFPEKIRMLKPITQDSLKALQEKDQRTVYRLTLVKGWNTEDVDAYANLFDIGKPDFI
EIKGVTYCGSSATSKLTMENVPWHSDVKSFSEAIATKSNGVYEVACEHVHSCCVLLAKSD
KFKVDGQWHTWIDYEKFHNLVASGKPFNSKDYMAATPSWAVYGAEEGGFDPEQLRYKKER
HHHKKETVDRVGE
>A0A8F2LEI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] haemuloni|TrEMBL
MEVDFTNAFPETKTEFPKAVPLKKRTRKTRTAKVFKKKETKVSHLTTSSVHLEKCPIYIF
YTTLTGSSLRVAKALHEKVAAIDGVEVPPRLLSLDDDVDDLEEYFLRTPESENPPIYLLV
LPSYETDSPIDYFLEHLTETYQDFRVDKYPLRGLAGFAVLGLGDSESWGGAQFCYQAKSA
DKWLGKLGARRLFPVGEVCMKHEGEPKTQDWINGFAELLVDEQPFLYEDDPSAFDSDASG
DEAEAEEEKDVVDVEDMGAIIRASKNKEILEPKQMVAQDSPTYKSLTKQGYTIVGSHSGV
KICRWTKSAMRGRGSCYKFAFYGIRSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRW
EVDPPEKVLSGALEGHYKKIKQMRGVPGIQIDRFQEAFQVRHCALSLVGEPIFYPHINEF
VGMLHEQHISSFLVCNAQHPDPLARLAKVTQLYVSIDAPTKTDLKKVDRPLNSDFWERLM
SCLDIVRTIQSHQRTVFRLTLVKGFNMTEVESYADMVERAMPSQIEVKGATFCGSSTGNG
NPLTMQNIPFLEECRDFCRQITAELQRRGLQYELAAEHSHSCCILIAHTKFKINDVWHTH
IDYKRFFELLESGEDFCDLDYICETPAWAVWGAEEGGFNPKDTRYDRKAEKLKKKQARDE
AAAKALQAKKGESIKAASEFAEHTRELFSLDRMSQSVDLDPNLLVMPRPSPNRDQELSEN
QIDIRDGLRFYHWVMNSRTAWACPRYVSGVHECITGISKEPLDKIVSPWGLMHSKQFDYS
AHLDSLRPQNPKIHRNVTAIDRGRFKKEESYCLSPSYAMLLDDCLLDYVDSLKELEDTVE
PALEKLKSVFNRGYGVHEVNIIVSDHSLVSETPIPSLGDLSPLKDFDEKVRAISYVSTRL
LVGKVHRLIVSELHGLSQEQWIMFKTIESNITSEFEPADFEWVTLEDELMRKIDSYFDVI
DLDKEDEAFREAWGEFLKNLYGDDLTFAKALRHEFVRLARNLMDRIARMIAKSSKSFNEI
SLTYFDKHMHKEYDITEL
>A0A7S0D3Q3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Micromonas pusilla|TrEMBL
MGAKQSSPADASGGETDASASARAAAPPSAGATKPRAGLDAAARDLSAALPAAEPAAAPV
GGRILFGSQTGTARRLAHKLANSLETRHGVRLETTDASGYDPEDLVREPVVLVLLSTYED
AEGNAVAPESARWLCRWAEESARDERFGALHLKDTRFAVFGCGNREYGAARFNAAARRLD
QDLARLGGERVLRRADGDESSGRMEEQFHEWADKLGERLKKAETREKGDASGASDAPRFG
AGKGRPRGSVAKKDEGSPTSVVADDTAEGRAYDTEEEEGSGDERGEDDDAALEAGSEDDM
DMEDIGGGGGGGERREMVTPQLRAALTKQGYKILGSHSGVKLCRWTKAQLRGRGGCYKHS
FYGIESHRCMEATPSLACANKCVFCWRHHTNPVGREWRWQMDDAETLVTSAISEHKGMIK
QMKGVPGVLPERLAEGMDPRHCALSLVGEPIMYPEIDKFVSLLHAKRISTFLVTNAQFPD
AITNLPPITQLYVSVDAATPETLKAIDRPLFGDYWDRFVGSLTALRDKNQRTVYRLTLVA
GWNASDAAEYAKLIDLGKPDLIEIKGMTYCGATSGASNLTMKNVPYHDDVKKFGEALCTA
RINLVSGRDAEKDAAEDEPLTGGTPRSAEYGLACEHAHSCCILLARKDPYLVDGKWHTWI
DYEKFQELVASGEPFTSDQYMLPTPHWSVWGAEEGGFDPGETRVRKVRNHPGKEKKEEAK
A
>A0A4S8R574|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Botrytis galanthina|TrEMBL
MPYDSWISRPIWSYEIDDIVALWHLYRIPIILTTATILILVRITLRPRTVREKLSASPLP
SSPVLPAVKEKISPPVIDEKKANGVKAPRRIVGGIKKRKSSEDNLQTCFEKIQPLVFFSS
LTGTTEKTANSFVESIRSDLSGRAIGQKIQFLESQLLDLSYIDYDDYFINPPKGESGVSY
FYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEEGF
CSQAKDVDKWLAKLTGRKRAFPLGVGDAKTDAKERLAEWKEGVVDVLEHIAKTGSLGEGV
VGSGDAVESDVEDIEDDDDGEVLFDEQNVASRKAKTQKKDDSLNDLEDIGGVLNNTETID
NATGEEPEELEIDFTTVGLKKGKAKTAPVVAKEMVPTTSPTYAALTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKV
DPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTS
MLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQRC
LEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGA
GLTMQNVPFYEEVCAFVEALTASLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTRI
DYKKFFECLESGEKFGPEDYVGAETPEWATWGQGGFDPRDERVYRKGKNKVPLPESQGMV
MGEVQDGGEDKVVENSTKDDLAF
>G3AU91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spathaspora passalidarum (strain NRRL Y-27907 / 11-Y1)|TrEMBL
MASGKLILGLCNVLYLISGGRWTFVLVTIVLSVLYNIEKNKIPIQTPQESSHIYEVDFTS
TSFTSSSYIPTSDTTITKRSRAKRSPKLIKVKKPVVDSQPQLTRTLVDLPKQAQIFVFYT
TLTGSSHRVAKSLVTKLEGLGLSHAPKLLSLDDDVDDLEEFFLKTPQPEDSEVKNVYLLV
LPSYETDSPIDYFLEHLQDTYQDFRVDKYPLRSLLGFAVLGLGDSESWNGEKFCYQAKLA
DKWMGKLGARRLFPVGTVCMKHEGESKAEEWIDNFTQLLVDEEPFYVDENDSVDDSDNED
SDEVTDSETLVDVEEMGNIIRKSGVESEAKQMVAKDSPTFKSLTKQGYTIVGSHSGVKIC
RWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKSNWRWEVD
PPEKIFNGALAGHYSKIKQMRGIPGIQMDRFQEAFQVRHCALSLVGEPIFYPHINEFIGM
LHGQHISSFLVCNAQHPDHLAKLNKVTQLYLSIDAPTKTDLKKVDRPLNSDFWERLMSCL
DIIRTTQAHQRTVFRLTLVKGFNMGDIESYADMVERAMPSQIEIKGATFCGSSNGNGNPL
TMQNIPFYEECKQFVIALNEELQGRGLDYDIAAEHAHSCCILMAQRKFQINGKWHTHIDY
PKFFQLLESGEDFVDTDYIKETPEWAVWGSDGAGFNPEDTKYDRKAEKLKKKIEREEKAK
LEIEV
>H2C8H1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Metallosphaera yellowstonensis MK1|TrEMBL
MATQFRIDTLSKIREELEKQRYHLIGGHSAYKKCHWTHEALTSGRYCYKGKFYGIESHRC
VQMTPVAAWCWFRCIHCWRLEPEDIGLEWDETKMPYMDDPEYIVERSIEEHKRSVSGYLG
RQGVDPIKAREALKPSHVAISLTGEPTLYEKVGELIREYHKRGITTFLVTSGVRPDVLAS
LEEEPSQLFVSLQAPNEEKHKMINRPIVSNSWNLVMRTLDILPSFSSPTVIRMTMIKGFN
MSDSDAEEFAKLIRFSSPTYVEVKAYMHVGPSTYRLTKDAMPRHGEVRKFAEKLAELSGY
NTLSEHVPSRIVLLSSIERPIQIGKAWNEKWDWRAQDVQDDIEGEYKGAELGCTEEGDGG
ERS
>A0A7S2WQT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eucampia antarctica|TrEMBL
EEMTNSSTTKNNVVVQLLATNEMDWWDELLNEEEEGEALGAASGITTSVGTGQRPPVVLF
VLPTWTGGTLPPEHQPLMNALEEIRSDWRVAKRPLESSGLQIAVFGMGSSAYDPETFGKP
AKSVFSHFLHLGAKPLLSSNHNNNNNNRRKNKTGKSLTLGDDEVGDASAIFQTWMNHTLS
HLSNSNHKRKKGKAAAAARNRQPLKQIQEDKKENDNDLDENGFNEDQDFLSDSEAEEEDE
PDVMDMEDMGSVMQQDSNAAAKEVDTEPKEMVTPKQAVALKKEGYKLIGTHSAVKLCRWT
KHQLRGRGGCYKHTFYGITSYQCMEATPSLACANKCVFCWRHHKNPVGREWRWKTDDPNF
IVREAVKMHISMIKETKGIPGVKME
>C9ZU99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)|TrEMBL
MELLSVTPGDLLVGCWVLTFVGIIFFRWFMHRRRSVEDQPPEAAQTTAGAQIHNGKSIIP
NRRDAGEGSSCRCCSSNDDVITSENVETCGKQQKRKKILVAYATQSNTSYKLSNKLISML
NLALHENSSAYGTCGGSLVLDAASGVSCCCSRDPKAGVAPEIKLLQLKEEATQCSTEHLL
ESGAYGLVVFFVSTYTGGTAPEPSHSFASMLKDAYLDFRVPRDVFAGVNFAIFGLGDIAY
GPEKFNRFAKDLYTWCKGLGGKFVIPPVYASESNTTTLFHVFSTALVKWIGRAAFTADGV
TVMKKKSMNGAQSLNRRLNNKNNEEEEQSVGGECVKDDEAVASGSGNHNSQNGDPSEGCG
SDDGDSDSENSDNNDDKNNNNNNSDDGDAEDVEDIVGEGDDYFSSTTNGEPPELLYPRLR
ENLQRQGYHLVGSHSGVKLCRWTKAMLRGRGGCYKHTFYNIASYQCMEMTPSLACANKCV
FCWRHHTNPVGRSFRWKVDPPRELIEGGLAGHRRMVKQMRGVPGVTPQRLEEALNVRHCA
LSLVGEPIMYPEINTFVDLLHEQNISSFMVTNAQFPEQLRDLKPVTQLYLSIDAPTPEEL
QRVDRPLFEDYWERCLACVRELRRKPQRTVFRLTLVNKYNTENVSAYADLVRLGWPDFIE
VKGVTYCGTSSTSTLTMKDNVPRHTEVVEFCEALCQQLATSNEPKEKRMWLGRDIVEEQQ
GAVAAAESGAETHVEGGMTTSSLCGPYRIACEHEHSCCVLISLRRFFIDGVWHTWIDYDK
FSELARSGRRDFTAAEYAAPTPPWAVFQSEERGFDPTQVRVIRKSGKSEVITSGC
>A0A7K7Z9Z7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Melanocharis versteri|TrEMBL
LDISMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPTSHEG
TADKLGNGCAPPQAQEIHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TRLQALCKGEKKPCSEKCKKGKCKSSGKQSKESSDHEHGMSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVGNVHGVSHSGYRLLYFVSQFLQAKLNCLMI
LALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIRQFKGVSGVRAARLEEALAVKHCAL
SLVGEPIMYPHINRFVRLLHQRGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFVEV
KGVTYCGESSASSLTMANVPWHGEVVSFVRELARLLPEYGIACEHEHSNCLLMAHSKFQV
DGEWRTWIDYSRFQELVREYEQSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQR
KNKARDISGC
>A0A1F9YVT8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon RBG_13_57_23|TrEMBL
MDSRTKEHLERQQYRIIGDTGAVKLCHWMRQKLIHGRPCYKEEFYGIDSHRCMQMTPSVN
ICNFRCLFCWRFHGMTGFEKSGYPEPEQLLEDCVREQALLVSGFKGDSRCDPKLWTEARE
PNQVAISLSGEPTLYPMLGEFIELCKRRGMTTFLVTNGSVPKALEELSTMPSQLYVTVAA
PNRELFERLCVPQTGRAWENLMRTLELLPSLSTRTVIRHTLIDGWNLGWEKEYARLDEIA
RPIFIEPKGYVFVGDSRTRMNASNMPSHSAVKEFSARLAEQLSLDVLREREDSRVVLIGK
KGSRLRVRD
>A0A257AJ60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|ANME-1 cluster archaeon ex4572_4|TrEMBL
MRKTLEKQGYHFVGPHKHSAVKTCLWLWKAMRREGEGNCYKGKFYGIAAHRCVQMTPSIF
CNQRCVHCWRPLEAFNIRKEEEVVWDSPEEIVDGCLKEQQRLISGFKGSHKTDKNTFAEA
QTPKHAAISLIGEPTLYPQLAELVQEFHSRGMTTFVVTNGTNPEVVRKISPSQLYLSLNA
PNEEIYKKVAHPDYNYWSRVKESLEELGRKGKEKEREEGEEAEEEWKRRTRTVVRITCVE
GLNIQNPEGYAELLKIAKPDFVEVKAFMHIGYSRRRLPREAMPSHSRVKAFASEIAEQLG
SGSGADYKVVNESEVSRVVLVSKK
>H2YWM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ciona savignyi|TrEMBL
DNHEHPIQESKMNGPVLFLISTYTDGTPPPSCEWFCRWLQDASNDFRVNKSLLSNMRFAI
FGLGNSLYSDHYNTIGRNLDRWLHKLSATRIFPFTAGDENVVQSKHGSIKLDFNAWKSEI
ISVLEYLLAGNQKNGVVTPVAEIDSVSSTTQCLVCTIHNPHQQEEEEEEEEKGEEGEDVV
DVEDVGDAMSHYPLLTKLGCPNRSNGTNGVSMRKRNSKKPPEMITDELRKSLSKQGTCTF
CIRVQVIRCKIDLHKIVVCMETTPSLACANKCVFCWRHHSNPVGTEWKWKMDPAVDVIKG
AIENHYDMIKQFKGVPGVKADRFAEGFSIKHCALSLVGEPIMYPEINDFIQMLHEKGISS
FLVTNAQFPEAITTLLPTTQLYVSVDAATQDSLKKIDRPLFKDFWPRLIESLKALSLKGQ
RTVYRLTLVKAWNVDELEAYADLVALGKPDFIEVKGVTFCGDSKSSDGLTLKNVPWHDEV
LHFVSQLTDMLDGYEIACEHEHSNCVLVAQTKFKSANGEWRTWIDYARFHELFQRFRATG
ESFTALDYTATTPAWAVLGADERGFDPQETRWRRKEKVTQGC
>S8F4Y2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii (strain ATCC 50611 / Me49)|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHYSGSTGDALSPPEQQDARRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLRLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQRNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ARGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
NQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQIRLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDERH
RMHAIGDERATGEGSDIDTKGGDRELQSTVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGREARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLFCLDLLKEKRQRTVYRLTLVGGYNMDD
PSANVSKECHTGAKPQGSSAAASAVGENSINEVERMCCRPATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREETTGEKADKERGKTKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTSYRRDGVWHTWIDYDKFHQLATSGNTTFTGFDYCAPTPSWAVYGSAEAGFSPLEKRV
FSKGKQKRLLRDKARTEQGENANGAD
>A0A202EBH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronolimnobius baerhuensis|TrEMBL
MPLGSSPRLMSDSEAGPNQVDSPDYHSENHTAAQTCGWTANALRGEGRCYKNIWYGIESH
RCIQMTPVVKCNERCVFCWRDHRGHAYELDDVEWDDPDAVADASLELQKKLLSGFGGNDE
VPRERFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHERDITTFLVSNGTNPDVLRECDP
TQLYVSVDAPERHTFDQVVKAVDDDAWDRLLETMAVLRAKDETRTVLRTTLVDGENMHHP
DWYAGFYDLADPDFIELKAYMHVGHSRGRLDRSSMPDHEEVMAFAEAVGEYMPEFSEVKG
VPPSRVALLSKTEDTWVPKLKKDSEFWERDPVTGD
>A0A176WGU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marchantia polymorpha subsp. ruderalis|TrEMBL
MSRQSTVLVVASCASVLVVSVSVFIYMRNKKTRAEADRELKNLLNKERRPQTEEEDLEEA
EDEEGEDEDEDDEDDDDDGDLEEPEGIGLDSKEQSSKVGGCCKTSRDSEKRSNGSGCCKA
KGTASSCGSKEQNGLAGDTQGNFIDDDVAFLYPAADEETPGATGNTECGNGCASHTTSNE
RSAEVCGKLLFVSETGTSQKLAENLGNQLLGRGVAVKVVDARSYEPEDLAKESLVIIVAS
TWSEGKAPKNGSYLLQWLDESSEDFRVGSGLLQNCKVAIFGVGSSVYGENFNVVAKAFES
HLTALGAHLILASGVGDDDLGDVEEQFETWSQSLVDHIRGTGAGSVLESSTENVPVSKEN
ETLMEEMVEEIYYTDTDEEDKENTDTLVDLEDMAGALGSTVKTKDPKKKGFVRKGKKNVQ
GGQAKKVEKYFQTPNGDDRKEMVTPVLRASLEKQGYKILGSHSGVKLCRWTKSQLRGRGG
CYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWRWKMDDPVEIVNAALDQH
TSMIKQMKGVPGVKPERLLEGMTPRHCALSLVGEPIMYPEINTLVDELHKRRISSFLVTN
AQFPDRITQLSPVTQLYVSVDAATKEKLKAIDRPLFSDFWERFTDSLTALRDKRQRTVYR
LTLVKGWNVAELDAYVQLLQLGQPDFIEIKGVTYCGSTATSSLTMENVPWHQDVKDFAEA
MVAATNGEYELSCEHVHSCCVLLAKVSKFKKDGNWYTWIDYEKFHDLVASGEPFSSEDYM
MQTPSWAVYGAEEGGFDPKEVRVKKERRHGASADPGGCT
>G3TPT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Loxodonta africana|TrEMBL
LDPSLDTWDFSSPLVSLWINRFYIYLGFAFGISLWICVQVVLKKQDKNSQEKSVPKATWD
LMTNGSVSHQKREVFVSGVKIFYGSQTGTAERFAAVLAEAVTSLGLPATIINLKDCEPDD
HLVEEVTNRNVCAFLVATYTDGQPTESAGWFCKWLEEAANDFRFGRTYLKGMRYAVFGLG
NSAYTSHFNKVGKNVDKWLWLLGARRVLTRGEGDCDVVKSKHGSIEADFSAWKTKLISRL
QELRRGEKKPSGSNCKKGKCESGQHGSESREQGSRSAEESPHRDAEEEEPWESSSEEECG
AEDPRGLNSVVDVEDLGGVVGRVKKDEKEKEQQEEKSSLFRSTGKNEDSERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCVETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIANHQNMIKQFKGVPGVRAERFEEGMKVKHCA
LSLVGEPIMYPEINRFLELLHQCKISSFLVTNAQFPEEISTRNLKPVTQLYVSVDASTKD
SLKKIDRPLFKDFWQRFLNSLKALAEK
>A0A2P9BUB3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium sp. gorilla clade G2|TrEMBL
MGIVDQEFLLKNILVTHCNEKKVKINISVIYGSGDGNSYNRAKDFLNELIEYFNNVHLFL
NDINEIINKDIYINHINSKMNDGDMVQKKDYNEKKIEIKNNYKNDKCDNNDNIGSNITFK
SNYINPSLNMNDMNNLENEIIEYFKLRFDQYQVNTNNNNNNKNNKMKNNKEKISRSGYEN
MVTLYFNKNINYLESYKENIKMFNSKFRNYVDCIIDNNKIGKIYFNLIDGNNHDYYSFFD
STENYNLNILFFFISTSSHGSFPNNSFKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNK
EYGDKYFCIPIKKCEKYIHSLGAQKLYKTLKLCDTQDNEETLFLWKCNIFKTLSLSLFFY
SFNYMKRWYMNKTIYDTLSYYCYFFSNHTNFYVNESEDNKYINDQKNQKKKNKKKKKSDD
HSINSMDLLEVSHSNNEYQENNPLIDHNNNKCFNNEIYNTQNGIYYSNFKDVQQMCLSNI
DSEEKKIKDKINTTMNEKREELNVNEDLDLHRGDTEKIEGCTNCNCESMNEYNDKNNTYH
TNNIETYKDSTSESEASSNDSYVDDEEEHIEVEDLISGEKKDMLSSSQRNKLTKEGYKIV
GSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVG
VKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIILERFEKAMNIKHCALSLVGEPIMYP
EINKLIDELHKRNISTFLVTNAQFPIELQNLNPVTQLYLSIDAPNKEALKNIDRPLFKDF
WDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEINSYINLIELGYPDFIEIKAVTYCGS
SQGYQLTMKNIPWHEEVYQFAWNLINKKKSLSDIYQISCEHKHSCSILIAKKIFKINNKW
NTWIDYEKFQQLIKNKQNFNALDYSIETPQWAIYGSQESGFSPCEKRVYTKGKYKNKKN
>A0A091V4L1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Opisthocomus hoazin|TrEMBL
LDVSMDVWGFFCTCLVSVWLHRFYIYSAVAFGISVWIVVQFTTAKTKKKGENSNGNPASS
GGIKEKVVNGYGSLQAKEVYVAGVKIFYGSQTGTAKRFAQGLAGAVVSLNLPVEVISMGD
YDPDDCLAEETSSRSICVFLVATYTDGEPAESAAWFCKWLEEAANDFRFGRTHLKGLRYA
VFGLGNSVYVDHYNTVGRNVDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSSGKQSKESSDHEHRASESENAEAEELFETSSEE
EADAEEAGSTNSVVDVEDLGNIMSHMKKAKREQELAEGDVGLSLTRENAGRKEEGEKREM
ITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAVENHQNMIKQFKGVSGVKADRLEEAM
TAKHCALSLVGEPIMYPAINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDA
STRESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLG
KPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVQDLADLVPGYEIACEHEHSNCLLI
AHTKVRL
>A0A7C5Y032|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
QRQHYKILGSHGGVKLCHWLKKSLKGEGVCYKELFYGIKSHRCLQFTPTVDHCNHRCVYC
WRNTEYTNCAPMASFDEPEFLVSEAERMQKMLLTGFGGILGRIDERKWLEAHHPNQAAIS
LAGEPLYYPKMSGLLQEFHDRGYTTFLVSNGTRSDMIEGLDVLPTQFYISLDAPTHEIYK
KVCRPLVDGWSGLKRSLELMGGMECRTVNRLTLVRDWNIMDAKGYADLISLAEPDFVEVK
AFMLVGGSRNRLTLDNMPTHEEVREFSSELSDILGYKFGGEKVDSRVVLLRK
>W7MM79|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella moniliformis (strain M3125 / FGSC 7600)|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKAEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDSTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSSRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKGARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKTVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A3M6VBK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Peronospora effusa|TrEMBL
MSPSTSTGVSLLLVAVSVLFYLSTRNRTLPDYAPATLHKVKKSHHKQQKNDKLSEPKPMT
VRILYGTQTGTSKKMAEKLEKTLFALNIAGFHFQTSVVSMKDYDQDNLEQEDIVVAILST
WTHGKPPKDAQMFCNWITDMTQDFRVSKTWLIDVPHAVFGLGNAEYDEDYGTAAKNLDRD
LAELGSPSLVALGLGDDNVDQFKQFDVWMDNLVAAMCKYSSEKVAAALNKSGSPVKVGKA
GKKEWLSQNEFRRQKRSEKAKAAAANGESIELNEEDLMNEEFLVDEFSDDEEQNQQNTND
DSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLR
GRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGS
IERHQGMIKELKGLPGLIPARWEEAFTVRHCALSLVGEAIMYPQINEFCKQLHDRHISSF
LVTNAQFPDKIAALDPITQLYVSVDAGTKESLRAVDRPLFKDFWERFLACLEELKHKGQR
TVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRG
FCSALCDRVSGDYALASEHAHSNCVLIAKKKFCRDGVWHTWIDYTRFHELVAKFYKDGAL
FTADDYTAPTPHWALYDSKEQGFDPVETRFRRTKDGKVTEFAYQSTESGLSFCYDYKEGR
KDEVASSTPSSGVAHRNVDKMCLSAMFSHLVELAAPHSTQVEG
>A0A673V0X9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Suricata suricatta|TrEMBL
MDPSLDSWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSKDKSVP
KATRDSMPNGHIALQKKDIFVSGVKIFYGSQTGTAKGFAASLAEAVASLDLPVAVINLQE
YDPDDHLVEEVTSKNICAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMGYA
VFGLGNSAYASHFNKVSKNVDKWLWMLGAHRVVARGEGDCNVVKSKRGSIEADFSVWKTK
FISRLQALQKGEKKPCGGNCKEGQCESSAEEELVESSSEEESGVEDHENPNSVVDVEDLG
KIMNCAKKEKREKEHQEENSALVRSTGKGEGPERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQNMIKQFKGVPGVKEDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWHRFLN
SLKALAAKQQRTVYRLTLVKAWNVEELQAYAELVSLGSPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPDYEIACEHEHSNCLLIAHKRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGATDFSAKDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A8D0J0Y2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQEGSLCVWSEDFLWFPD
WHSKGVSILAEAVTSLDLPVAVVDLKAYDPDDYLLEEVTSKSVCAFLVATYTDGRPTESA
EWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVM
ARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQALRQGERKPCSGNCRKGKCESHQRGTG
QAEPGPQAQEGFRRRDAEEEELLGSTSEEESGSEDQQSGSSVIDVEDLGQVMDRVKKEKR
EKAQQEGETGVLRSAVKNEANEPRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPDIILKEA
IENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRFVKLLHECKISSF
LVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQR
TVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVR
FVSELVGLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQELIQEYEDSGGSK
TFSAKDYMARTVVCNLIS
>A0A2K5ZTW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mandrillus leucophaeus|TrEMBL
MDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICLQIVIKTQDRNLQEKSVPKAPQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVMSLDLPVTIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGRPTESAEWFCKWLEEASSDFRFGKSYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHKDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVFLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRH
QRKNKSKAISGC
>A0A6P8PQ87|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Geotrypetes seraphini|TrEMBL
MDAPVEISDFLYACFMSFWINRFYIYSCTAFAVGVWILFQFITIKKKKQGEPPYQNGVVQ
YGREDLHSTQKEKETHVSGVKIFYGSQTGTAKGFANSLAKEIIALGLPAEVIDMKDVDPD
DILIEQTTSKNVCAFLVATYTDGRPTENAEWFSKWLEEASTDFRVGRTYLKGMRYAVFGL
GNSVYVNHYNTVGKNIDKWLWMLSASRIMTRAEGDCNVVKSKHGSMEADFDSWKSRFLSQ
LQMLCKGEKKSCGGKCTKTKCKSKKNHMGEGLDHDQEALGESEQDKTEEELFETTSEEES
GAEEREGAGSIIDMEDLGKMMGHMKKAKKEQELSERSGKVGPFQEKNGMGEDSEAREMIT
PALRDALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIENHQNLIRQFKGVPGVKADRFEEGLTA
KHCALSLVGEPIMYPEINRFIKLLHRHRISSFLVTNAQFPQEIRILEPVTQLYVSVDAST
KDSLKKIDRPLFKDFWQRFLDSLKALADKQQRTVYRLTLVKAWNVDELKAYADLVSIGKP
DFIEVKGVTYCGESTASNLTMANVPWHEEVIHFVQELTDLLPDYEIACEHEHSNCLLIAQ
KKFKIDGEWWTWIDYDHFQELIRMYEDSGGCKTFKASDYMAKTPRWALFGAKERGFDPKD
TRFQRKNKIKDISGC
>A0A8J4L4V8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eudyptes chrysocome|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKYNGN
PASSEGIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVI
SMGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKG
LRYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEA
WRAKFLSRLQALCRGERKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFET
SSEEEADAEEAGGTNSVIDVEDLGDIMSHMKKAKSGLDSRVGGGMYHPFPRLSRNPIRTR
ILAAQGGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCA
LSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESL
KRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIE
VKGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFK
INGEWCTWINYDRFQELVQEHERSGGSKTFTAADYAARTPLWALFGSRERGFDPLDVRYQ
RKNKARDISGC
>A0A7J2LYN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MEASVVTVPPHVRELMERQGYKFVLNHSAVKPCYWFREALMRGRTCYKQKFFGITTWSCL
QMTPAASFCNLQCLYCWRLNASDLPPEHRWKEIPEEGSKWDDPEDIASESIRIQRMLVQG
YKGVKVFREDWLREAENPRHAAISLTGEPMLYPHIGGLVEAYSRRGMTTFIVTNGTLPER
LENIEKEPTQLYVTVPAYDEKLYKQITRPLIPDAWQRLNRTLELISSLSCPTVMRITTIK
GMNMQHAELWAKLINEYGPTYVEPKAYMYVGYSRRRLSRDCMPSHEEVRRFAEELAKHTG
YRILSEVPESRVVLLSRLEKPIRFDVR
>A0A1V4YZ24|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccales archaeon PtaU1.Bin030|TrEMBL
MTLSQRWSELVGRGLPQGVFRYDGKGPLAHHRFHLRVDSKQKGILIIDASQLVELNGTAL
DYMRCLLEGRTEEDMFRYMSHRYKGLDRSTASDHYSRISDQLARFMQGETSILETMGTDR
PTIGADDFPAPYRMDLALTYRCQNECAHCYNEPRDMKELDEDRWMKVIARTWQLGIPHVV
FTGGEPTLIPYLGRLIARSESYGQVTGLVTNGRNLSAPGYLKDLVEKGLDHVQITVISHR
EDVHDRLSGAPGAWRETVEGLRAALKEDLYVSTNTTLMSANQDDVLETMRFLIGLGVRNI
AFNSVIRSGKGKETEGVAYPVLQDLLTKLSLLAEEAGVHMTWYTPTPYCELNPINLGLGI
KQCTACSINMAVEPDGTVLPCQSYYFPLGNILKDPWAYIWGHDLCKEIRGRMYVEERCSE
CALLDTCGGGCPLSRKMGSRACWDRRPS
>A0A497MJL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MNVPESFRKILIKQGYRLVGKHSGVKICEWTRRSLTRGEYCYKQKWYGIESHRCLQCSLA
LFWCLNRCLYCWRSFKLFLGAEMKVEPDDPEWILEGLIEAQRMLLVGYKGNPKVPRWKWE
EAQNPTNLAISLIGESVLYQRLPEFIAVAKERGMNTFLVTKGTYPEMLAKLEVEPTNLYI
SLCAPDKETFESLDRPITPDGWEKQMESLELMKSFSCRKVIRITLVKGYNMHGIDDYARL
IAKAEPDYIEPKAYMWVGESRKRLPGDAMPTHEDVIEFARKLAEETGYRFVDFFRPSRVA
LLSAK
>A0A7J8QZM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium davidsonii|TrEMBL
RCLKPLKHLPLNPNPRPGKLFFLTQTGTSKALAQRLLDLLSSKNNIPFDLVDPHTYEPED
LPKESLIIIIASTWEDGNPPQNSKFFVNWLADISTDFRAGNLLLSDCKFAVFGVGSRLYG
DTFNAVARDLGKRLRGLGATEMVPVGEGDVDGGELESVFEGWSEKVVTVLKGGLVMENEN
GIVYESDVESLESDDDDDGEGGGEDIVDLEDIAGKGPSRKKSVNVAETNGKLDGKREMVT
PVIRANLEKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTAIDLHTKMIKQTKGVPGVTQERLMEGLSP
RHCALSLVGEPIMYPEINALVDELHRRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAAT
KDSLKAIDRPLFGDFWERFIDSLKALKEKHQRTVYRLTLVKGWNTEDVDAYSKLFVLGKP
DFVEIKGVTYCGSSATSKLTMENVPWHSDVRAFSEALALKSEGEYEVACEHAHSCCVLLA
KTEKFKVNGQWHTWIDYEKFHGLVALGRPFDSEDYMALTPSWAVYGAEEGGFDPDQSRYK
KERHHKSKR
>A0A7K4IP82|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MEELAPSSLTRALVRQKYHFVGRHSAVKGCRWLHETLIHDRPCYKQKFYGIKTHQCIQMT
PTLLYCTQQCLFCWRAQSGDLKMTWDEMKLPTWDSPEKIVEGSIKAQLRILSGYKGNPKT
DQQKFKEALTPRHVAISLTGEPTLYNYIGELIQTFHKRGLTTFLVSNGTMPTVLAKMSEE
PTQLYISACASNEETFKHICRPQISKAWRRLVETLELLPSFKCPTVIRITSVRGLNMNDV
TGYTKLIKKANPTYVEPKAYMHVGFSRLRLGYASTPSHQEIREFAEKIATATSYNIVDES
RESRVVLLSKHKKPIRFGYG
>A0A7J3EEY0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MASQENALESFKRTLLKQGYRIVGSHSGVKICEWTRKSLTQGRYCYKQKWYGIESHRCLQ
CSLALFWCLNRCLYCWRSFRVFLGAEMDVKPDEPEWLLDGLIKAQRELLIGYKGNIKVAP
SRWEEAQNPTNVAISLIGESVLYPYLSEFIELAEKRGMKSFLVTKGTYPEGLEKLRVEPT
NLYISVCAPDGETFNRLERPIKRNGWEAQMRSLELMKSFNCRKVIRITLVKGYNMHNIEG
YAKLIERAEPDYIEPKAYMRVGESIKRLPEDAMPSCENVLEFAEKLAGETGYIVEDFFKP
SRVALLSKNKR
>A0A497JSE9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MVLSAVDADVLGVLAGLYRRQKYHLVGAHSAVKRCRWLYESIVHGRACYKQKFYGIRSHR
CVQMTPSLYYCTMRCLFCWRIQPRDVNPAFKEPEPPDRWDSPEEIVDGAIRAQLRLLSGY
KGNPKADKRRLREAFEPKHAAISLAGEPTLYPFLGELIREYHKRGFTTFLVTNGTNPRVL
AQLEEEPTQLYVSLYATDAKGLARLCRPRIAGAWKRISETLGLLSSFNCPTVIRITLVRG
FNMDDVEGYARVIGKAEPTYVEPKAYMHVGYSRKRLGFSNMPTHAEVQRFAFQLAERLGY
NVLDESKESRVVLLSRLEKPIKIA
>A0A7C5IE65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQLSYNQYSLITLFKKQKYQLINEHSAVKKCRWLHQSLTQNRYCYKQKFYGIQSHRCIQM
TPSLICNMQCKFCWRIHPNEDLKPPLNFLIQKWSNPEEIVEECIKAQKRILSGYKDQVKK
GKIDGKKYFEALNPKHAAISLDGEPTLYPKLSELIQEFHKKNFTTFLVTNGTKPEVLKNL
SEEPTQLYLSIYAPNKKIFMNLCKPVNINFWDKINESLELLSSFKCPTVIRLTLVKGENM
EDLDGYAKLMEKASPTYIEPKAYMFVGYSRLRLKFENMPSYEEVKAFSEKLAEKTSYNII
DESKESRVILLSKLKKPIKFS
>A9A9M3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis (strain C6 / ATCC BAA-1332)|TrEMBL
MIPEQIHNILRKQHYQLKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPRDLGMDSFESPEWKEPEVVAEDILNMHKTIITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIKVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKENWESILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQDELLEMGKILGENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A7K4IAI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MWEESEYLQEIVPSSLIQALDKQKYHFVGRHSAVKRCRWLYETLIHGRPCYKQKFYGIKT
HQCLQMTPTLFYCTQQCLFCWKAQSGDLQIAWDELKLPRWDSPEEIVEGSIKAQLKILSG
YKGNPKANRQKFKEALTPKHAAISLTGEPTLYSQIGELIQTFHKKGFTTFLVSNGTIPSA
LARLSEEPTQLYISVCAPNKKTFKDLCRPQIPNAWERLRETLEFLPSFKCPCVIRITSVR
NLNMKDVDEYAKLIRKANPAYVETKSYMHVGFSRLRLGFKSMPSHQEIREFAEQIAIEIG
YNIIDESQESRVVLLSRLKNPIRFGSV
>A0A850VVW5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fregata magnificens|TrEMBL
LDVSMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIIIWFTTTKTKKKVTESSEGIEDKL
VNGYATVPAKEVYVAGVKIFYGSQTGTAKKFAKGLAETVISLNLPVEVINMGGYDPDDCL
AEETTSRNICVFLVATYTDGQPTESAAWFCKWLEETANDFRFGKTYLKGLRYAVFGLGNS
VYVDHYNAVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLTRLQA
LCRGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGASEYENTEAEELFETSSDEEADAEEA
GGTNSVIDVEDLGNIMSHMKKAKRERELEEGDIGMSLTQENAGRKEEGEKREMITPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMMLQEAIENHQNMIKQFKGVSGVKADRFEEAMTAKHCAL
SLVGEPIMYPEINRFVKLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEV
KGVTYCGESSASNLTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKI
NGEWCTWINYDRFQELVQEHKRSGGSKTFTAADYAARTPHWALFGSRERGFDPLDVRYQR
KNKARDISGC
>A0A1S4B6R5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nicotiana tabacum|TrEMBL
MSPSLSSYPTRLAILTLLSATTVYFFYKSRRHLFKRLTSLNPNPKTPKGKIFFISQTGTS
KTLAKNLHSLLNLNGFDFDLVDPKDYEPEDLHKESFVLIIASTWENGKPPSNAGFFIDWL
NESVDDFRVGSLLLSKCKFAIFGVGSGSYGETFNAVARDFSKKLRKLGGVEVLAVGEGDV
DEGNLDEVFGEWSKRVIGVLSNLGENGGYMVNGVGDGSEDEVVSEGDDDDDEEDDDEFEE
NDEESGIVDLEDIAGKGPSRKKGVGDKLVNGKLNGDIVNGEKEMVTPVIRASLVKQGYKI
IGSHSGVKLCRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GKSWTWKMDDPLEIVDTAIDLHTKMIKQMKGVPGVKAERLSEGLSPRHCALSLVGEPIMY
PEINSLVDELHKRRISTFLVTNAQFPDKIKLLKPITQLYVSVDAGTKDSLKAIDRPLFGD
FWERFLDSLKALKEKEQRTVYRLTLVKGWNAEEVDAYFNLFSIGKPDFIEIKGVTYCGSS
ATSKLTMENVPWHSDVKEFSEALAKKSNGGYEVACEHVHSCCVLLAKVDKFKIDGQWYTW
IDYEKFHDLVASGKPFTSKDYMAPTPSWAVYGAEEGGFDPEQLRYKKERRHKSSRKENGS
>Q2FS62|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)|TrEMBL
MHSVQCDQSKKALRRMGYQFFHPDSSAALKPCLWCKRSLSGGDQCYKNQFYGITSHRCVQ
FTPTLRCNHTCLFCWRSFEHEYTGEKDLLPQEIVSRIPFLQKKALGGYKVSPKVTKEKWE
EALQPDQYAISLAGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPDVLKRCHPYQKYISL
TAPDRETYLRIARPREDYWDQVLESISCLGHETDAGDRTAIRVTLVRGINDQDPEGYARI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHDEIEHFTKRMLPHLSYRVLGENTLSRVI
CLERVS
>A0A136J529|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Microdochium bolleyi|TrEMBL
MAGPTGSGASGLIEAWHQHRTYTLVVATGIACVVWLLVTRKSEHEGPKADAPKAVSSSAR
SASVAQDEKPSQVDQPLPTTAKSKEAQKEPRRIKGEVRKNNAGQNKSPVLATSQPTQVLV
FFSSLTAGTEKRAGAYMQILEPLLAAIQKESQSTFLKPELLNLAEVDYDEYFINPPKSAG
EVDVPASYFYLFILPSYNIDTINDTFIEHLQETHNDFRIDTAPLSGLLGYSVFGIGDREG
WPTEDEGFCFQAKEVDKWMAKLTSRKRAYPVGMADARLDYQDRLSEWTDGIKSVLEMVAR
TGSLGEGVPGSGDAVESDDEGEVDDDDGEVVFEDGSVPLRNTKRKEGRNVDDVEDLGRIM
KSSREDGTDTARAPLAVDFTTYKSSTSKGVPAIKEMVPKNSPTYTSLTKQGYSIVGSHSG
VKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRW
KVDPPELIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINEF
LGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFQ
RCLDILREKRFKQRTVFRLTLVKGFNIDDEVEGYADLVERGLPCFVEIKGVTYCGTSTSA
GAGLSMANVPFYNEVTDFVEALTAKLQERGLGYGIAAEHAHSCCVLIASDRFNVDGKWHT
RIDYQRFFELLEERGADGDWTPEDYMGEATPEWATWGNGGFDPRDERVDRKGRPIAV
>A0A2E1FIZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKILEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNTRAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSAENMPRHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GQEISPMPIPKATMFFPEDLGIAPSVKHLPIIQ
>A0A7J2Y786|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDADRKEVLERQGYRIVGNHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPAVD
SCNLGCLFCWRTQEWGSNSLVEADDPGFIVEASIDAQQALLSGYKGNPSVTREKFLEARH
PTNVAISLTGEPTLYRRLAEMINEFRRRNMSTFLVTNGTTPAVLRRMWAEGCLPTQLYVT
VAAPNERIYAKLMAPKSDHEFSKLKETLALLPRLPTRTVIRHTLVDGWNLGWEDEYASLD
RLGEPMFVECKGYSFVGESRLRLQAENMPPHASIRLFAERLGDRLDYEIAAERADSRVVL
LTKDGKLHPLPS
>A0A7D5M7C7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus oxyclinae|TrEMBL
MSCSGETVEEDDEQLLQIRPVITAQLKKAKYGVADHSTVGLCHWTKKSFKHEGSCYKHKF
YGISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMQMKPEQVAEPEQILTKLMGERKKLI
NGFYGDSRNDKQRLDESLLPAHYAISLSGEPTMYPKLPELIKYLKTFEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFMKINKPRYDDSWERWNRTLDMLKDLKTRTV
LRITLIRDHNDQKESIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEYTNMLEMEEVKSF
SEEIANQSKIFSIMDESIVSRISILQNNERFIDRFIPTYANTI
>A0A2E6C0Q6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDTLELSDQDPLEMLYESVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYNRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNSAAWDKFEETIDLLPSLDTRIVCRHTLIKGRNMNPDHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHDDILEFSNALAPLTGRKLLDDSPPSRVALV
GKEIIPIPIPEATMHFPDDLGIAESIKHLKIVQ
>A0A2E1HZ74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKICHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDTLHLEEQDPLEMLYDSVKAQRRLLSGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYNRLSEYIELCHSHGMTTMLVTNGTLPKVLEKLETLPTQLYVSVDAP
NKEVFDEICRPKWNSAAWDKFDETIDLLPSLDTRIVCRHTLIKGRNMKPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSNALAPLTGRKLLDDSPPSRVALV
GKEIVPIPIPEATMFFPEDLGIAESIKHLKIVQ
>A0A2E2HHY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTXHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKNVFDDVCRPKWNSGAWNQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSXHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLIQN
>A0A7K4DET0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MHSEACKALRKQGYQFVNATSSAAVKPCMWNKRALRGGDMCYKAQFYGIESHRCVQMTPT
LRCNQQCLFCWRSFEHEVTEEEECPPAEIIENLPRLQKRALSGYKVSPYVTPERFAEALS
PTMVAVSLSGEPTCYSHLPELIDGLNAEGYTTFLVSNGTRPDVLDRCRPYQTYISLDAPD
RETYLRLCRPREDYWDLVQESLSGLARRRSAIRTTVVRGYNDFAPEGYAAIYQDSGARFV
EVKGYMYLGYSRNRLQKDQMPKHRDVRAFAAKIVDHCDYFIKDESPVSRVVCLERDV
>A0A178FDI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichophyton violaceum|TrEMBL
MAAIPLQIALSLWHAYRAYILVIIVVTFLAVTKFSSQRKQVENQPRGVEQVTHKTTISDK
PAQPGNTTLAKSTPLKSEPKPGPKRLRGLRPLKGVANVTAQAVSAIRPIFFFTSLTGTTE
KSARAAFESVRSKLQAAPQNAQCKVLDPELHDLSYIDFDDYFVTAPKPPTSEPGLSYLYC
IILPSYDIDSIINNFLNHLDETHNDFRIDTSPLSGLTGYSVFGFGDKEGWPTVEEGFCSQ
AVAVDKWLAKLTGKRRAYPLGFGDAKTDGDHSLQEWCDGIVSVLHDISENGGGLGEGVPG
SGDPIESDEEDAEEDSQQPQNLNRPRRTKTRNSQVADLEDIKFNPEVPLDDEPIDFTTYA
PTKISSLSSKEMVPSTSPTYTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYG
IKSHLCMESTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLR
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLSLLHGEHISSFLVCNAQHPDELA
ALQRVTQLYVSIDASNRESLRKIDRPLHRDFWERLQRCLDILREKRNVHRTVYRLTLVKG
FNIDDEVEGYADLVEKGLPCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNE
ELERRGLSYGLSAEHAHSCCVLLASKRFLINGKWHTRINYERFFELLEREKQTGESFTPE
DYMRETEEWALWGNGGFDPNDQRVHTKGKNKGKIGVPPPSGKVILAGTA
>A0A7J8WNJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium aridum|TrEMBL
PGKLFFLTQTGTSKALAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWED
GNPPQNSKFFVNWLADISTDFRAGNLLLSDCKFAVFGVGSRLYRDTFNAVARDLGKRLRG
LGATEMVPVGEGDVDGGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDD
DDGEGGEDIVDLEDIAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGS
HSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKS
WQWKMDDPLEIVNTAIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEI
NALVDELHRRRISTFLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWE
RFIDSLKALKEKHQRTVYRLTLVKGWNTEDIDAYSKLFVLGKPDFVEIKGVTYCGSSATS
KLTMENVPWHSDVRAFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDY
EKFHDLVALGRPFDSDDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A4U0TSU5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salinomyces thailandica|TrEMBL
MDTTSSLFQLPDELLYLWHAYRTEVLLSAGLVFAVVRLALYWRGGSRKNKEILTPPVLTP
VDEKPLVIQSAKESLQDADHYEAPIPSAKPARPKPGPKRVTGVKKAKRPADPDATLDGIQ
PILFYYTVGGSTQAYAKTLAESLSATTTPTILPPQLHDLAETDYDDFFLGTPKQPGTIPF
YLLLLPTYNIDTNLDSFLEHLRETHHDFRIDTAPLAGLAGYSVFGFGDQTEWPSEAEGFC
TQAVEADKWMARLTGRKRAFPLGFGDVSAKKGVEERLREWTEGVTAIMKDLAAGKGLGEG
VPGSGDAVESGDEEDEEDVDDEQPKRTTTKRSKTADLEDMKAPIAVDFTPSQPAPPKPMV
PKTSPTYTALTKQGYSIIGTHSGVKTCRWTKSALRGRGSCYKHSFYGIASHLCMEATPSL
SCSNKCVFCWRHGTNPVGTTWRWTVDPPDEIYAGITAAHYAKIKTLRGVPGVRADRFAAA
LRIRHCALSLVGEPIFYPHINALLALLHADHISTFLVCNAQHPDHLAALGPVTQLYVSID
ASNAESLRQIDRPLHRDYWDRFLRCMDVLYAKRHTTRTVFRLTLVKNFNIAEEAEGYANL
VLRARPAFIEVKGVTYCGTSTSKGAGLSMANVPFWHEVQLFAAELQRALKARGLDYGVGA
EHAHSCCLLLAERERFFRVPAAGSSTDGKVGAKQWHTQIDYAQFFRCLESGRPFAPEDYV
GTPTPEWALEGKGGFDPRDVRVDRKGRAIEIAGKEES
>A0A178EF12|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenochaeta sp. DS3sAY3a|TrEMBL
MHMVFVNSTMDQLPSELLYIWHTHRIPILLSAVAATAVVRLAIYSRSRRTRVSESPAPSS
PIEKKTVELKPEWLPEYTTLTSTDVLVDTPPEEDAKVADPVAKPKRAPKTVKGRKIQKKA
PPPTAVFDHNNDKIQPLIFFQSLSGTTERFAAQFAKVLTEWTTGCDQSDSFLEPQSLDIS
YIEYDEYFINPPKSDANVKYVYIILVPTYNIDTVLDIFLESLQETHNDFRIDTAPLRELL
GYSVFGFGDREGWPTEEEGFCSQARQIDKWMARLTGRKRAYPLGMGDVKSDAEKLLQDWR
LGVQEALVDIAEGRGLGEGVPGSGDAAESGDEEDETTEENNGQPSRVDDVEDLGSMVTDF
TPPTPVDFTTYKATSKPKPKLVAAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTK
SALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDPPELI
FDGITTAHYKKIKMMKGVPGVRAERFTEAMRIRHCALSLVGEPIFYPHINELLSIMHRNR
ISTFLVCNAQHPAQLATLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRA
RRFEQRTVFRLTLVKGFNMAEEVKGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQN
VPFYEEVAEFVTELEKELNSRGLTYGIGAEHAHSCCILLADRTRFMRGGKWATRIDFERF
FDLYEGTVAGTRVEKDEHGVEKVVGWRPEDYVGGETPEWALWGNGGFDPRDQRVYRKGKG
PKGESDAGSLVEVKAGVGAKAALEF
>A0A4C2ELC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula mannanilytica|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAAKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTQEMGEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWEQDEFVEY
>A0A2H9L189|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_59_7|TrEMBL
MATCAIPQNFIDKYERQQYSLVGEHKHSAVKICSWTKRALLGSGSCYKQKFYGIQSHRCL
QMTPSLFWCTFRCLHCWRSIEANLGFDMSSAVLDDPEKILDGAVAAQRKLLIGFKGNEKA
NAEKWREAQNPNQVAISLAGEPTLYPKLSGLIRCARRRGMTTFLVTNGTQPGALLTLKEQ
DALPTQLYVSLCAFDKESYARVHQPVIDDGLERLLETLRIYPALPTRRVIRLTLSKGLNF
SNPKKYAALIKQADPDWVEAKSYMAVGYSRNRLGPKYMIPHEEIREFSEELARHSGYEIT
DEQKESRVVLLSRDAQAAANRFITQND
>A0A8J8PTL0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. D5|TrEMBL
MADKLAITVLISIAYIFTGSFITSPIFGGRHSAYKKCHWTHESLVTNRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDDTKMPAYDDPEYIVERSIEEHKRAVSG
YFGREGVKLEKVKDAMKPAHVAISLTGEPTLYEKLGELIREYHKRGLTTFLVTSGIRPDI
LASLEEEPTQLFVSLQAPNEIKHKMINRPVVANSWQLLMKTLEILPSFSSPTVIRLTMIK
GYNMSDEDAKEFAKLFQIAMPTYIEVKAYMHVGPSTYRLSKDAMPRHNEIREFAKLLSNY
TGYKILSEHVPSRIVLLSKLDEPIKIGNAWNERWDWRTVDIEDDINGEYKEAELGCTEGS
T
>A0A218ZR73|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuniculiplasma sp. C_DKE|TrEMBL
MENKYAQVYKKQHYGLVGKHSAVKVCHWTKSEMTGGASCYKGTFYGINSHQCIQMTPALN
SCTENCSFCWRFNGFDSMHIGDEDDPEFILNESIKAHLKLISGFKGNPKVTEEKWKEASN
PKHIAISLTGEPTLYTRLGEFIELANKRGMSTFLVTNGTLPMVLEKLNPLPTQLYVTTAG
PDKKTFNELLNPAMGNAWENFQKTLELMPSLDTRKVIRHTLVKDFNMPFIDEYAKMDSIA
QPDFIESKGYVHVGQSIARLSIDNMPSHNDIMDFTVKLGEKVGYEVTAERKESRVSLLAK
DPSKSKINFESI
>A0A7C4H901|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Staphylothermus marinus|TrEMBL
MKTGLNWREIERMREEFWSSNPIYRTIYERMRKQGYHFIGRTGSVKRCYWTREAIVNNRF
CYKCLWYGIESHRCIQMTPVSIWCWNRCLHCWRIQPDDIGMHWDETTLPVVDEPEIIVEE
SIRVFKQIIGGFKGSFKANQQMVREALEPKHVAISLTGEPLLYPRLSDLIKEYHRRGFTT
FLVTRGVRPDVLTTLDEEPSQLYISLEAWCREKYVSYNKPFIPKAWDLILKTIEYLPSFK
SPTVFRITIIKGFNDSDEAIKGFKKLVEIGNPTYIEVKAYMYMGYSKSRLKIENMPSHSE
IRDIARKLSIETGYMYLSESIPSRIVLLSRIEKPIRHGKGCPDGLKHPEKYTPVYTEEYE
ELTEENQ
>A0A2N6NG46|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Beauveria bassiana|TrEMBL
MAMDPLSGANGQSALFNINGGLSGLLDVWHTNRTPIILLALCGLVVLRLYIHAYEEKPDL
KIIPKIYQNTDYKNVAYKKSDNVSPPQVQEKTAVKTVGPRRIKGGVTKKPETTEESIDLN
KPVKVLVFFSSITTKTEKIGQDYIAKLEKSVAQLAAETARPILAPELLDLTEIDFDDYFI
APPKSDDGAQFLYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLMGYSVFGFGD
REGWPDEAEGYCFQAKEVDKWMAKLTARKRAYPVGMGDMKSDHAERFSEWSSGVEEVFGQ
IIRTGYLGQGVAGSGAPVESDDELEEDYDDGEVVFDDEKPSKRENGKSSSNLDDVEDLGR
VIKSQGGDANPRAPIAVDFTTYNNKSNPQNKVKEMVAKNSPTYAALTKQGYAIVGSHSGV
KICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWV
VDPPELIFDGVKENHYKKIKMMRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFL
GMLHKERISSFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNR
CLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSN
AGLTMSNVPFYWEVCEFVRALDRRLQEKGLAYGIAAEHAHSCCVLLASERFHVHGKWHTH
IDYDRFFELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVVR
EAPE
>A0A1Y3GD32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanonatronarchaeum thermophilum|TrEMBL
MKLVSAREELESQGYRFVGRHTAVKLCHWLREGLQGNPGCYKQRFYGIDSHRCLQMTPTV
VHCNQKCLFCWRSYENWTETKLTEHDPAKKLLGGVIKAQKQLLTGFGGSPEKYSQKLLEE
ARNPKHLAISLSGEPTLYPEINQLIEEAHKKQLTTFLVTNGQQPETIKNLTPPTQLYISL
DAPNKKTYNQLCRPTKKNGWQNLQKTLKTLPKHNGRTAIRITLVNGYNDQKHNQYAEILR
EAQPDYIEIKAYMHVGQSRKRLNRQRMPTNQQVKKFSEQIADKTDYTLTDHVPESRVTLL
TKDKTPKINNK
>A0A8J4ZCU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nymphon striatum|TrEMBL
MIAVLDWIFSIFNGIFPLVIVGIIGALSYYFYKRNYCHIKKVEKLFQHVVPTKSLEVSGT
VKKDVSSTCFDCSCEEKSESLEESGIVKKDVSSSCFDCSCEEKSESLEESGTVKKDVSTY
ADYSSQEKSKIKIFYGSQTGKSEEFARILVSEAEAAEIEVDLVNLKDYEPEDQLCHERNI
CIFLIPTYTDGQPPDNAKWFCTWLLEASTDFRTQKSLLETVRYTVLGLGNSMYQDNFNKV
AKSIDHNLHKLGAKRAMPLYLCDENTAQSKHKGLEGDYEAWKSVLLQFMADGGNGEVQYE
SSDEEPDSEIKEDDLVDVEEIGNVMNKMKKSLESKEPKEMINPSLRKSLTKQGYKLVGTH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTEW
KWKMDQPELIINGALENHYKMIKEFKGVPGVQPERLAEGMKVLHCALSLVGEPIMYPEIN
RFVDMLHEKEISSFLVTNAQFPEAITNMSPVTQLYVSVDASTKDSLKKIDRPLFRDFWER
FLDSLKALSDKGQRTVYRLTLVKAWNTDELTNYAKLVSLGNPDFIEVKGVTYCGSSKAST
LTMQNVPWHEEVLGFVQELVDQLPDYEIACEHEHSNCVLIANKKFKVEGKWHTWIDYTRF
HELIKDFKKSNKTFSSIDYMAETPSWSVIGSKEHGFDPIETRWYRKNRKDISGC
>A0A8C8EF28|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Otus sunia|TrEMBL
MDMWNFFYTCLVSLWLQRFYIYSAAAFGISIWIAIQLTTTKTKKKGEKSRGNPAASEEDK
LVNGHATLQAQAVCVAGVKIFYGSQTGTAKRFAKSLAEAVVSLNLPVEAISMGDCDPDDC
LSEETSSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGNMYLKGLRYAVFGLGN
SVYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQ
MLCRGEKKPCSGKCKKGKCKSPGKQSKESSEREQRASGYENTEAEELFETSSEEEADAEE
AGGTNSVVDVEDLGNIMSHMKKAKRERELEEGDVGMSLTRENAGRKEEGAREMVTPALRE
ALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILREAIENHQNMIKQFKGVSGVKAARFEEAMRVKHCAL
SLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEV
KGMTYCGESSASSLTMANIPWHEEVVLFVQELADLIPDYEIACEHEHSNCLLIAHKKFKI
DGEWCTWINYDRFQELVQEHERSSGSKTFTAADYTARTPHWALFGSRARGFDPLDVRYQR
KNKARDISGC
>A0A8J8J8U3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 21S9|TrEMBL
MAIVVKANPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQFYVSLTAPDIETYNRVNVPMIPDGWEKIKETLRLMRDAETRTVIRLTLVKGE
NMHSPEKYAELIKIANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDSRGRGLTGRFISD
>L5K5M3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pteropus alecto|TrEMBL
LDPPLDTWDFSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQDKNSQEKSVPKTTQDL
MTNGYISLQKKEVFVSGIKIFYGSQTGTAKGFAADLAEAITSLDLPVAVIDLKEYDPDDH
LVEEVTSKSICVFLVATYTDGRPTESAEWFCQWLKEASTDFRFGKTYLKGMRYAVFGLGN
SAYVRHFNKVGKNVDKWLWMLGAHRIMTRGEGDCDVVKSKQGSIEADFRAWKTKFISQLQ
ILLKGEKKPCDGNCKKGKCKSNEHIAEEIEPWSHAQDGLHQRDTEEEEPFESTSEEEPDT
EDHQSLSSVVDVEDLGKIMNRVKKEKREREHKEEKTGLFRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKLMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPDINRFLKLLHENKISSFLVTNAQFPMEIRNLKPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
DKEWWTWIDYNRFQELIQEYEDSSGSKTFSAKDYMAKTPHWALFGASERGFDPKDIRYQR
KNKSKDISGC
>A0A3B3XNY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia mexicana|TrEMBL
MLALFTVISFFTGSLSASDTKVPPDVHSPTENYLLWMWNNRLYVYSAAALLLGFCFLLQV
TRRKINHTKDSGSKDSGLKVQKAAKNSSDEDADVHVSGVKIFYGSQTGTAKGFASELSQE
VQALGIPAEVIDMKDFDPDDRLADECVSKSVCVFLVATYTDGRPTQNAEWFCKWLEEAST
DFRYGNSFLKGLRYAVFGLGNSVYVGHYNTVGTNVDKCLWMLSARRVLSRGEGDGNVVKS
RHGSVQADFRAWKVRFLSRLRALARGEKKSCSGNCKSGASCKNRKKHGAPEEEEHGSEVE
LIESSSEEEESGWPDEKTSRSVVDVEDLGNIMNSVKKAKGVKGEQGGQMVKLSKHNGVMK
TEDEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESH
RCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPG
VKPERYEEGLAAKHCALSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPEEIRNLVP
VTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVEEL
QAYAELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPHYQIAC
EHEHSNCLLIAHRKFKVNGEWRTWIDYDRFQDLVQAHEDSGGQQTFSALDYTAKTPSWAL
FGSNEQGFDPADTRFQRRNKTKDISGC
>A0A075HH06|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_63_D09|TrEMBL
MSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHSCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEDIMTKLMAERKKLIM
GHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQKLEDENALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDTRTVL
RITLIRGYNDDEEMIPVFASLLRQSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRCFA
NKLAQENNTFAVMDESEISRIVILQNKKRFVDRFIPAYC
>A0A520KB07|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MKESTRELLRKQRYQLVGDHSAVKLCHWLKESLMRDRVCYKQKFYGIKSHRCLQMTPAVN
WCTQKCLFCWRPVRFTEDVPPDVDAPKYIVEESIEAQRTLLSGYQGVLDRVNKKKLEEAQ
TPNNVAISLSGEPTCYPLLPELIEEYTKEGFTTFLVTNGTNPDVLRDMDPLPWNLYVTLP
APSKDIYQRLCNPTIPDGWERINETLELFESLDTKKVMRLTMVKGINMVDPANYAQLIEK
ASPTYVEVKAYMFVGFSRARLTIEHMPRHEEIREFADRIASESSYRVVDESPESRVVLMS
R
>A0A662TR10|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MIPEEVAKILRKEKYAIVGRHSAVKKCRWLHESLVNNRYCYKQKFYGIKSHRCLQMTPAV
IYCTHQCLYCWRVQKGDIGLDWEMPSEWDEPEIIVEESIKAQRQILSGYKVHKKVPYEKY
LEAIEPKHAAISLSGEPTLYPYLGELIEEFHRKGMSTFLVTNGTQPQRLAEITQPSQLYI
SLSAPDIETYKAICRPLSPKLWNRIMESIELIQSFTCPTVVRITAVKGLNMKKPEKYAKI
ILKGNPTYVEVKAYMYVGLSRQRLKFENMPTHEEVKRFATQLPEELPYDIIDESEPSRVV
LLSRLKKPIKIGKE
>A0A7J9Q078|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|archaeon|TrEMBL
MNPELKKILEKQHYKIVGEHSGVKTCHWLKEKLIHNRCCYKEKFYGIKSHRCLQMTPTLN
NCTQNCLYCWRYQDFTEQKLKKFDEPEFILEESIDAQRLLISGFKGDERCDKKMFEEASN
PNQVAISLSGEPTIYPKLAEFIEVCRKKNMTTFVVSNGTKPEMIENLKPTQLYITVAAPN
REIYKKLCAPVMKDGWEKINESLEILPSLDTRTVVRHTLVDKWNIGYEDYYAKLDMKADP
DFIECKAYMFVGYSRQRMNLENMPSHEKIKSFAEKLSDLTGYEIAGEKKDSRVVVLAKDK
SKMRI
>V6ARG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis uzonensis|TrEMBL
MSCSGEFVEQDDLIQIRPSIVKQLKKAKYGVADHATVELCHWTKKSFKGDVGCYKHKFYG
ISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLQMDPGKVAEPKQMLDKLMEERRKLIMG
HYGDPKSDRKKLDESLMPSHYAISLSGEPTMYPKLPALIRYLKSLPATKSVFLVTNGQEP
HMIQRLVDEDALPTQLYLSTNAADRESFMRINKPRYTDSWERWHNTLQIMSNLNTRTVLR
MTLIRDYNNSLQDIEAFASMIKNSGIHFIEIKSYMHIGRSTNRLERTNMLEFAEVQHFAT
ELAKKSGVYSIMDDSESSRIVVLQNQQKPIDRWIAAYR
>A0A5D2HKP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium darwinii|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKFRRRCLKPLKHLPLNPNPRPGKLFFLSQTGTSKA
LSQRLLDLLSSKNNIPFDLVDPQTYEPEDLPEESLIIIIASTWEDGNPPQNSKFFVNWLA
EISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDNLKAIDRPLFGDFWERFIDSLKALKEKHQ
RTVYRLTLVKGWNTEDVEAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSEGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVASGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKR
>A0A7J3BPG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MELDRETVKKFLNAQYRIAGKHSAVQICSWTKKALRGEGVCYKQKFYGIDCHRCAQMSPA
FLWCQESCVHCWRPAEWMKKKDFDKMGIDDPEIIINQIVKERKKLITGFGGLKDISRALY
EESYNKFPSHWAISLSGEPTIYPKICELIGQLKKHGEVRSVFLVTNGQEPKRLQELINKK
CLPTQLYISLSAWDEKSFAKLNRSVYPDGWKRLLKSLSLIKKMKCRTVVRLTLMRGINDS
EEAKKAFAKILESSKPLFIEIKAYMFLGQSRKRLNEENMPTHEYVKKFADDLLQLLPSYK
MESEDKASRIVLLKRKNSRIKNIITRKLTRQRS
>A0A2E9LGA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Pacearchaeota archaeon|TrEMBL
MKLNNRIVKQLRKEGYRIVGNHSAVKICRWTKKSLRNEGECYKSKFYGINTNSCCQISCS
LLNCQNKCIHCWRDLKYSCPDEIKNPDSANSIIEGCIKEQRKLLEGFKILPETKYKTVSK
VNMKKWEEAQLPTQFAISLTGEGTLYPKIGELILELRKRGKTSFLVTNGLYPEKIKELKN
KKQLPTQLYVSVNSPNEEIYNKFHRSSKKNAWKKLNETLELIAKLKSKTRTVVRLNLVRN
LNMDNKYIKEYAKLIKKASPLFLEIKGYMAVGHARERLGYERMPTDKEMEDFAEEISKKT
GLKILDKHEFSRVLVLGKNKKDLKIKKNGI
>B9WIU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)|TrEMBL
MGFGRILLCACSILYLSTGGRWTVVTLVFVLSILYNKDKHQDEKQLGSSSSAPQPKPKKP
SPIYAVDFTSTTSFTSPTTINIPRRVIGSRAKRSPKVFKASKNAIQQQQPVLTKTTVDLA
KSQIYIFYTTLTGSSQRIAKSLYEKLSGIEKFESPPKLLSLDDDVDDLEEYFLKTPQDNC
IYLMVLPSYETDSPIDYFLEHLIDTYQDFRIDKYPLRKIIGFSVLGLGDSESWNGDKFCY
QGKLADKWLGKLGGRRLYPMGQICMKYEGEPKAQEWIQNFASMIVNDSDNDQPFYIDVGS
DDIDDSDAEDESVGSDDADTLVDVEDMGDIIRKSGKTSSSSFSSGIETKEMVAKGSPTFK
SLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLACSNKCVF
CWRHGTNPVAKSNWRWEVDPPEKVMAGALEGHYQKIKQLRGVPGIQMDRFEEAFRVRHCA
LSLVGEPIFYPHINEFVGMLHQQHISSFLVCNAQHPDALARLAKVTQLYVSIDAPTKQDL
KKVDRPLNSDFWERLMSCSDILRTIQSHQRTVFRLTLVKGFNMEDIESYADMVERARPSQ
IEIKGATFCGSSNGNGNPLTMQNIPFYEECKTFVENLNQELQSRGLDYDIAAEHAHSCCI
LVADKKFMINGKWHTHIDYPKFFELLESGKEFVDLDYVKETPEWAVWGSEGAGFNPEDTK
YDRKAEKLKKKAIRDEQAKKLLDQQKSM
>A0A665U1A1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Echeneis naucrates|TrEMBL
SHPPRTWLLNVISASHLYTESWFMSVWHNRLYLYSAVALVFGVWFSLNMALKKKSISKDI
NPWVYKAVKIQNCPDRAAVVHVSGVKIFYGSQTGTAKGFAKELSEEVTNLGIPSEVIDMK
DYDPDDQLPDECTSKSVCVFLVATYTDGQPTENAEWFYRWLEEASTDFRYGKTYLKGLRY
AVFGLGNSVYVGHYNTVCKNVDKWLWMLSGMRVMTRGEGDCNVVKSHNGSIQADFQAWKV
KFLNRLQALAKNEKSCSGNCKTGSSCKNKRNDGQLEDDLIESTSDEDESGLQDEKKSGAV
VDMEDLGSMMNIARKAKSNEEGRGDVHTVKLSKFTAVKKLADEEERREMITPALKEALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWHWKMDPAEKILQDSLEKHQNMIRQFRGVPGVRPERYEEGLAVKHCALSLVG
EPIMYPEINTFIRLLHSHQISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIAMGQPDFIEVKGVT
YCGESSASNLTMANVPWHQEVVAFVQQLAGMLPQYEIACEHEHSNCLLIAHTKFKVDGEW
WTWIDYQRFQELAHVHEESGGLQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRNKT
KDISGC
>A0A662IP40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MLAQSTTSTIINLLRQQKYQLIGSRKTAAVKKCHWLHAALTSNRFCYKNWYGIESHRCIQ
MTPTLACPNSCLHCWRIERGDPSTPSWKEDDFITYDDEKTIFEQAIKAQFRILSGYKSNP
KVIKERYVEALHPRHFAISLAGEPTLYDKLSDFIELCRSKGFTTFLVTNGMYPERLAKLL
DRGQPSQLYISVNASSEDKFKALSRSSLADGWQRLLKSLELLRGFTCPTVIRITLIKGIN
DHEGDLEGFAKLIVMAEPWYVEVKGYMYLGYSRFRLKLENMPKHSQILEFARSLSKVTGY
QLIADSLSSRVALLSRIGEPAKVKP
>A0A1H8I7A8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halorientalis persicus|TrEMBL
MSDSESGSGGPKQVSNPDYHSENHTAAQTCGWTKNALRGEGKCYKKIFYGIESHRCIQMT
PVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDASIELQTKLLSGFGGNDEVPREMF
EEAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLAECDPTQLYVS
VDAADRATFDETVKAVEDDAWERLIDTLDVLAEKDETRTVLRTTCIEGLNMHNPGWYASM
YERADPDFVELKAYMHVGHSRGRLDRDSMPDHERVVEFAEDVMEHMPHDVLKQVPASRVA
LLATERNTLVPKLQKDSEFWE
>A0A3Q3WCM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mola mola|TrEMBL
MSSLPPVSQNAHSHSENYAMLIWHNRSYLYSAAALLFGIWLSLKLALKKVTCQGYTYCLL
THDKCTVLTPLLDIYIICDSSFVQGFAQELSDEVKTLGIPAEVIDMKDYDPDDQLAEECT
NKSVCVFLVATYTDGQPTENAEWFCKWLEEATTDFRYGKTYLKGLRYAVFGLGNSVYVGH
YNTVGKNVDKWLWMLSGKRIMTRGEGDCNVVKSRNGSVQADFLTWKTKFLNRLQALAKGE
KKSCNGNCKTEGPCKNKRKDEEEKAAEELIESSSDEEESSLQDGKKSSSVFDMEDLGNIM
NRAKKAKSVIPLTCFCFCAGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCM
ETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPGVKP
ERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSQHISSFLVTNAQFPEEIRSLEPVTQ
LYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLAY
SELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVSFVQQLADMLPQYEIACEHE
HSNCLLIAHTKFKVDGEWWTWIDYERFQELVQTHKETGGEQSFSALDYIAKTPSWALFGA
HEQGFDPADTRFQRRNKTKDISGC
>A0A133UKW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA259I07|TrEMBL
MVLTKEEKQNMENGGYRLVGEHEHSAVKICRWTKKSLLDKEICYKQKFYEDIHGIKTHRC
LQMTPSLPFCDNKCVFCWRNSEINSPEWRGAVDDPSEILDEAIESQRKLLSGFKGNPKAN
KRKWEEAQNPNLSAISLDGEPTLYPKISDLIEECYRRDITPFLVSNGQNPQVLTEIKEPA
QLYISTVAPDKKTYINVCRPLVSNPWENLIQSLELLPSFDCVKVLRLTLVKDLSLKDPSG
FSKLIKKADPDFVEPKGYVAVGHSRERLGTSFMPTHSEIKKFSKKLAELSGYEIVDEFKP
SRVVLLS
>W4IL33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum NF135/5.C10|TrEMBL
MGIVEEEFLLKNILGTHYNKKNVKISISVIYGSGDGNSYNKAKDFINELIEYFKNVHLFF
KDINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQINESYNNDDNVDHSNMDGNIIDK
NNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRKEKISNYENMIPLYYNKNINYL
EPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNNHDYYSFFDCTENYNLNVLFFF
ISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFFSCIGFGNKEYGDKYFCTPIKK
CEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKTFSLSLFFYSFNYMKRWYMNKG
IYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEKKKKKNNKIKKKKGDLSIYPME
QLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTHNNIYDNDKDDHQIFLSTIGND
EKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCTNCNCQSVNEYNDTSNTNDTNN
TNIMNNTNNTNIMNTNNTNIMNNTNNTNIMNYTNNIRTGENCVSESETSSNQSYPDDEDE
QIEVEDLISGEKKDMLSSSQRNKLTKEGYKIVGSHSAVKLCRWTKSQVRGRGGCYKHTFY
GINSYQCMEATPSLACANKCVFCWRHHKNPVGVKWRWNMDKAEIIVEEIIKKHKAMIKEL
KGIYGIIMERFEKAMNIKHCALSLVGEPIMYPEINKLIDELHKRNISTFLVTNAQFPQEL
ENLNTVTQLYLSIDAPNKEALKNIDRPLFKDFWDRYIKCIKILKNRKERKVFRFTLVKEY
NMMENEIDSYINLIQLGYPDFIEIKAVTYCGSSQGYQLTMQNIPWHEEVYQFAWNLINKK
KALSHIYEISCEHKHSCSILITKKIFKINNKWNTWIDYEKFHQLVKNKENFNALDYSVET
PHWAIYGSQESGFSPCEKRVYTKGKYKNKNQQS
>A0A8C2KMI1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FTGALKDVWDFTESYLLTVWQNRVYVYTTAAVLIGACFTVNMLFKKKKTVDPVSPWLYKS
ARKQELSAETEKVILVSGVKVFYGSQTGTAKGFAKELSGDVSAQGIQCEVIDMKEYDPED
RLAEECTSKMICVFLVATYTDGQPTESTEWFSKWLEEASTDFRYGKTYLKGMRYAVFGLG
NSVYVGHYNTVRHTWIFLSIFDRIVLHLTLNIFSVFRSAACRPTSKGEKKACSGKCKKGS
CKNKKKHKEEAEDSHSLAEKNNSEELMESSSDAESSSEEEEKSHGSVIDVEDLGNVMNRM
KKAKRMDGDEEDSQRVKLSKQNGVRKSESEEERREMITPALRDALTKQGYKLIGSHSGVK
LCRWTKSMLRGRGGCYKHTFYGIESHRRMETTPSLACANKCVFCWRHHTNPVGTEWRWKM
DPAEKIIQAAVENHRNMIRQFRGVPGVRPERFEEGLTVKHCALSLLGEPIMYPDINSFLR
LLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSIDASTKDNFWQRFLDSLRALGEKVGPL
CCNPDKTRKYIRFALGQPDFIEVKVLLYHLLSFLPLFFPVCLQFKVDGEWWTWIDYECFQ
ELIKGYEESGGTKSFSAMDYMAKTPSWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A8C2AMQ8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
MICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYVGHYN
TVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQALAKGEKK
ACSGKCKSASCKNKKKHKEEAEDSQSHAEKNNSEEELMESSSDAESSAEEEKSHGSVIDM
EDLGNVMNRMKKAKVKTKPCSSTSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCAL
SLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLK
KIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEV
KGVTYCGESSASSLTMANVPWHEEVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKV
DGEWWTWIDYERFQELIQEYEESGGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQR
KNKTKDISGC
>A0A7J2HF01|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MNSALKEASEPMRGELAKLRKAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGIRSHR
CLQMTPSLQYCNMMCLFCWRHHTINRVEGPAEDWDEPEEILDGLIKEQRQLLSGFKGNPI
VDRRLFEEAMEPKHMAISLDGEPTLYPYLGDLIKLARSRGMTTFLVTNGTNPARLRELIE
ENAEPTSLYVSFYGPDPETHRRICRPLIDDSWERLVKSLRLMGEYRKSRRVIRLIMIRGH
TIHSPEKYAEMIKMAEPDFVECKGYMHVGESQRRLRRDAMPSMDEIRTFARKLASLLGYE
YLAEDHASRVSLLANPSSSRYEEVRSRVSRLSSFENAP
>A0A7J2K7J0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MAIAHGDTRLKLDEVNRLRRAGYRIVGRHSAVKICHWTKSVLRGGKNCYKGWYGVKSHRC
LQMTPSLQYCNMMCVFCWRHHTMNRIKPYGGEWDPPEEILDGLIKEQRQLLSGFKGNPKV
DLRLYDEAMEPSNAAISLDGEPTLYPFLGELITLLHERNMTTFLVTNGTMPERLKILLDM
GAEPTNLYISLYGPDRRTHVMTCRPLINDSWERLIDSLRVMRTFTRSRKVIRLTLVKGYT
MRDPERYAELIRIADPDFIECKGYMHVGESQKRLPRSAMPSVMEVEDFAKRLQIHLKGYE
YIAKDVPSRVCLLAKKSSPHYDDVVKNAEKMNELIQNIS
>G1X0R3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Arthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491)|TrEMBL
MAEMYKSRSPDLIELWHTIRIPLIIAIGVLYITIRLRSILRARTPVLTTPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPTKPNVDAPPAVEGG
EEITQPNGKLIQVFIFYSSLTGSTAKYAEKLSNDLFSEPLHIPKPTPPSVDNAEPGPVVE
KATFLAPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFP
IGMGDVKGDALASMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPPKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLQYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYANLVEKGLPAFVEVKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNEALQKRGLGYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKEKTA
EEVAAELAAEAAEAESGCG
>A0A7L0GKS4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Herpetotheres cachinnans|TrEMBL
LDVSMDTWNFYTCLVSLWLHRFYIYSAVGFGISIWIIIQFTTAKPKKKVTEHGNPAASEG
IEDKLVNGRATLQAKEVYVAGVKIFYGSQTGTAKKFAKGLAEAVISLNLPVEVISMGDYD
PDDRLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRYAVF
GLGNSVYVDHYNAVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKARFL
SRLQALCRGEKKPCSRKCKKGKCKSGKQSKESSDREHGASEYENTEAEELFETSSEEEAD
AEVAGGPNSVIDVEDLGNIMSHMKKAKSSIETVMLNIVYQLVWFVYQLLQAKINCLIIFC
LFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMAAKHCALSL
VGEPIMYPEINRFVKLLHQYSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRI
DRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKG
VTYCGESSASSLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAHKKFKING
EWCTWINYERFQELVREHERSGGSKTFTAADYTARTPRWALFGSKERGFDPLDVRYQRKN
KARDISGC
>E9FRP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Daphnia pulex|TrEMBL
MKVAHPPLIGSFFLPTLGLAVFSLALGYWISRRKKGNINNDEPNVTEKSSDDTVGETDSM
SALDNLKKKKKKHDCNCGSKETSKFEKQPSQIKIMYGTLMGKSKKFAEILSEHVSEETPV
SVVNLKECDSEDIFVGPDTKDTLFIFIVSTYAEGSPPEDAEWFYKWLEDSALDFRVPQTF
LAEVRFSVFGLGNSLYFENYNVIGRNIDKWLSKIGAERYAPLGLGDENVSESLHGNIEAD
FDHWCEGILNLLKNPQGTTEKKSGCSKGNDCCSKKGKKKSVNRSQKKKNNIVEETDVTRD
SDSESDTNEAVVDLEDLGSFVRVENKAGEDSEEDEEVTTVDGEPREMLTPQLRESLTKQG
YRLIGTHSGVKLCRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHS
NPVGTEWRWKMDPAEFILEGALEQHAKMINQFKGVPGVQPHRLAEGMNPVHCALSLVGEP
IMYPEINRFMRMLHEKKISSFMVTNAQFPEAIRQLEPCTQLYVSVDASTKDSLKKIDRPL
FKDFWERFLDSLRALSAKGQRTVYRLTLVKAWNVEELESYAELVKLGEPDFIEIKGSVTF
CGTSKASTLTMENIPWHHEVVTFGEKICSYLDAYGLAAEHEHSNCILLAKRSKFFKDGRW
NTWIDYDKFHQLMQDYYLSDGKATFTSEDYMAPTPNWAMFGSPEHGFDPVENRWHRKQPK
KDISGC
>A6UUA6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)|TrEMBL
MEKNENIPNEIYTVLRKQHYQIKEHSAVKLCGWVKKALLENKSCYKSKFYGIATHRCIQC
TPSVIWCQQSCIFCWRALPSDIGMDNNSNYKMPKWDEPEIVAENILKMHNTLITGYKGIL
DRIGEQKYNELANPKHVALSLSGEPTIYPYFKELIEIFHKKGFSTFVVSNGILTEVIEEI
NPTQLYISVDAYDLDSYKKICRGTETQWNKIMDTLDILNDKKRTCLRTTIIRDYNDDIEK
FIPIYEKANANLIELKSYMNVGYSRKRLNLDDMLKHEEILELSKILDNNSFYKLEDDAFD
SRVSVLMNENKKIKLKLFE
>A0A813B0J9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium microadriaticum|TrEMBL
EDLDLLFGSKPSTSSPSVVPAVPRGGVEDPALEQPECLLCACWVLLLMFVPFTFDVQWHA
PTFDVDWAILASARSADASWVKRLRQERELKAVHLELTTRCNAACPQCPRNLQGGVENPV
LAAHHSELSLEDVRAILPPGFLRQLRKVYLCGNFGDPAVAQDCAEVIRYLLSVGGSRVGL
FTNGGARSPVWWEELSIPELGSIMQPPERAFVRFAIDGDESTNHLYRQHVRWERLMANVD
AFLAAGGNAEWDFIVFEHNEHQVEAMRSLAEQKGFTKFNAKKTARFIDKARGAVKPSVPV
KDTSGSVVRTLRPPANPAWQNEAALESVQKAACLVLRELLQAVEKYGSIEAYYDSCEISC
KVAKEKEVYISADGLAFPCCWLAAEMYRADLPNSGREVVRLAKAAFPQEGLHALSALRRG
VGAAVDRRAGLFQQLVPAAMRQPSLREGRLRTCSGVCGVEVNAFAKQFAGAAQHLDPVRR
SRAASAATVAPAPVEGSPVEVWYGSETGTAEQLALRAAEALGSEAAVSVPPPWDQVEARL
HGCRALVLVLATWGQGEPTEDAQGLFRFLRERGGKAKRVFPPLPVAIFGLGSSLWPHFNA
AAREAEELIRSLGAPILIRLGEGDAAKGHLDSDFDAWLQELLVALKKLGLDSSGGPPRVR
RSTDSVAIVPMTVVRVTRLAPRDPVARYFEVQLRGAVSHGFGDALGVLPTHGGFAGARRP
RWYTIASAPTSSDDQLPSQASRDFLQLLPRACREAAMAMTIDCGKLVSKFNSPPAAMSLK
VDGTVRAATPNRGAGVQMDGVLAYALKMFLKVEEARIDPGMNVGSDIMKVPVPELGPMLP
PPQPHSVQRPPKDPRFRPIPLADRANLVFSKGSVGHPFTCAAACRYVKRKGGCRRGADCN
LCHECFWSKDSEMWEQAQEEKVAQAGPVFVPSQEDVTDEFAGLLSEVCMLQPLPQQESYP
ASGFLGSMDSAVGMEGFAGVEMPAMNPGSLGHPHSCGPACKYAQKSRGCKDGDMCSHCHL
CQWTRFSAKSLKL
>A0A6A6IFN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trematosphaeria pertusa|TrEMBL
MASLERLEGLPAELLLIWHTHRVPLLLSAASLIAIVRLTIYMRSRRTKISLSPAPSSPVA
KVNAVELKPEWLPESTTLDSRTSNLDNHTEDTVVVAKLKKGPKTVRGRKLPRRKAEAPPN
FYHQTDKIQPLIFFQSLSGTTERYAAQCSKALTEWTSGCDQSTSFLQPQLHDLSYIEYDD
YFISPPKAEPHIKHFYLVLLPTYNIDTVLSTFLENLQDTHNDFRIDTAPLSGLLGYSVFG
FGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKSDAEMRMEEWRIGVQEA
LVEIAEGRGLGEGVSGSGDPAESDEEDVDVAEHRDARLDDVEDLGATVDASTAPVPVDFT
TYKSRTISKPTPKEMVPVTSPTHAALTKQGYTIIGSHSGVKICRWTKSALRGRGSCYKYS
FYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPELIFDGITTAHYKKIK
MMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLEMMHKERISTFLVCNAQHPA
QLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRFEQRTVFRLTL
VKGFNMAEEVKGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPFYEEVAQFVTE
LEKELISRGLSYGIAAEHAHSCCILLADSTRFKRSGKWATRIDFERFYDLYEGKVQGTRT
DEEGKVVGWRPEDYVGEETPEWALWGNGGFDPRDQRVWRKGKAPKSEGGSVGMGAKKGDV
AVLEI
>A0A8C5LHH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Jaculus jaculus|TrEMBL
MDPPLAVWDLSSSLLSLWMNRFYIYLGFALGITLWICVQIVMKKQVNREKHLPGTTQELM
KKQIFVSGVKIFFGSQTGTAKGFARILAKAVTSLHLPVAIIDLRDYDPDDHLVEEITSKN
VCAFLVATYTDGRPTESAEWFCRWLEDAASDFRFGKTHLKGLRYAVFGLGNSAYSSHFNK
VGTNVDKWLWMLGAHRVLTRGEGDCNVVQSKHGSIEADFRAWKTKFISQLQALCKGEKKK
SCGGKCKKGKCESKPRGSGETQPASGAQGESHHREAEEEEPCESTSEDDFGTDDHQSPSS
VVDVEDLGDIMNHMRKEKRENDQDEKASVLRNTEKNEDNKGRAMITPALREALTKQGYQL
IGTHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPV
GTEWRWKMDQPEMILKEAIENHQNMINQFKGVPGVQSTRFEEGMQIKHCALSLVGEPIMY
PEINRLLKLLHQCGISSFLVTNAQFPVEIKNLIPVTQLYVSVDASTKDSLKKIDRPLFKD
FWQRFLDSLKALAAKQQRTVYRLTLVKSWNVDELQAYAELVSLGNPDFIEVKGVTYCGES
AASSLTMANVPWHEEVVRFVRELVTLIPDYEIACEHEHSNCLLIAHRKFKIGGEWWTWID
YSGFQELMRQYEESGGSKTFSARDYMARTPQWALFGARERGFDPKDTRYQRKNKAKDISG
C
>A0A842W739|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MSKIKPELKKLLENQQYAFIGSHSAVKICAWTKKSLLDEGVCYKEKFYGISSHRCCQLST
TVNHCQNRCIFCWRPTQYTEGIDIKGKLDDPKKLIDKAIKAQQKQISGFGGNKKLNKKKF
KEAQIPNQFAISLSGEPTLYPKLGELINEILKRDATAYVVSNGLCPDVLADLHPLPTNMY
LSLDAPNKELFRKIDQSQIKDAWEKLNKSLEILKKLNTKTVLRITVLKGLNDVHPEQYAS
LIKKASPDFVEVKAYMFVGASRQRLTIDRMPRHHEVKAFSKDILKHLKEYKLKDEKKESR
VVLLAKD
>A0A1Q7FC03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_4_48_7|TrEMBL
MSCSDEHVSHSTDNLIQITPQLKARLQKAKYGVYNHSAVELCHWTRKSFANEGNCYKHKF
YGISTHQCMEMTPAAMNCENRCIYCWRPTEFYDTLEMPEELVDEPDVIVEQLMAERKKLI
NGYYGNTKNDKRKLDESLLPAHYAISLSGEPTMYPKLPKLIKYLKSLKATKSIFLVTNGQ
EPDMLRRLTAEDALPTQIYLSTNASNKKMFHQINRPLHKDAWERWWESLRFLATVNTRTV
LRMTLIRGYNDSKNFVGEFGEMMAKGNPHFIELKSYMHIGMSNRRLEQDHMLEMQEVRDF
AVQLCEKMSPFKMMDESEVSRIVVLQNQARYTDRWIKEYIMPAS
>A0A8J8PG38|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanomassiliicoccus intestinalis|TrEMBL
MNDVTETLKKQQYKLHGDHAAVKLCHWVKQSLLHDRPCYKQEFYGIKSHRCLQMTPVVNM
CTHNCLFCWRVQGFDSENIAWKEPEDILEHCLEQQKKLVSGFGGDPRCSKEMWLEAREPK
QVAISLSGEPTLYPMLGDFIELCKRRGMTTFLVTNGTTPEILEKLDPLPTQMYVTVAAPN
EEVYKRICVPRIPDGWEKLMKTLELFPSLNTRTVIRHTLVQGWNVGWEDEYAKLDETADP
MFIEPKGYVFVGDSRRRMTIDNMPSPASVAEFGKRIASRLGMELLRERPDSRVCLLGDKN
AQVKIPGLE
>A0A7L3ZXS7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Circaetus pectoralis|TrEMBL
LDVSMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHGEKPNGNP
ASFEGIEDKVVNGYATLRSKEVYVAGVKIFYGSQTGTAKRFAKDLAEAVISLNLPVEVIS
MGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGL
RYAVFGLGNSVYVDHYNTVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAW
KAKFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEELFETS
SDEEADGEEAGGTNSVIDVEDLGSIMSHMKKAKSSIETVMLNNFVYQLVCFVYQLLQVKM
NCLIFLFVCLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAM
TAKHCALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDA
STKGSLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLG
KPDFVEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLI
AHKKFKINGEWWTWINYDRFQELVREHERSGGSKTFTAADYAERTPCWALFGSRERGFDP
LDVRYQRKNKARDISGC
>A0A7S1VJU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sexangularia sp. CB-2014|TrEMBL
MVLSKNLVLVGVTAGIGAGVLWWMQRRRVAAPVPVATPTAAPSSSAPISVSVDTPTGDEM
KNMPRAIIYFATNTQTAAQCADRAASVLAGGGWAVTVEDMCLVDPEDALLGSSGGIDTLL
LFIVATGSNASLPDGARGWSDWLHFEAQSPRSGACLARTRFAVFGLGDSAYGANFAVAAR
SLERQLLALGAKRAVRKGTGNTGAGEHKPLDTLLVDWLALLQQAEAARRAALSKRTAAEA
REEARALLAESDSEDEEGSEGPSSDVEMEDIGADSGPAEVDGLREMLTDRVKASLVKSGY
KVIGSHSAVKLCRWTKAQLRGRGGCYKHTMYGITSYRCMEMTPSMACANKCTFCWRDYRN
PVATEFNFVQDPPDWIVQEAIARHTQMIRTLRGVPGVEPDRYQEALQPRHCALSLVGEPI
IYPAIGKLLEELHSRHISSFLVSNAQFPDKMAALPPVTQLYLSVDAADRQSLKDIDRPLF
PDFWERFLASIDALRDRRDRTVFRLTLVKGWNSSTVHGYASLVRRCRPDFIEVKGVTFAG
PGTGARQMTMANVPFHEEVVQFCEALAASIASGAGSDLETELHDESLGAVPE
>M3YXM6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mustela putorius furo|TrEMBL
MVVGRRDKSSQEKSVPKASRDLGTDGSIPLQRKEVSVSGVKIFYGSQTGTAKGFAASLAE
AVTSLDLPVAVVDLKDYDPDDHLVEEVTSKNVCAFVVATYTDGRPPESAEWFCKWLEEAA
SDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWTLGAHRVVARGEGDCDVAN
SKHGSIEADFGAWKTKFLARLHTLEKGEKKPCDGSCRRGQCESSAEEEPFESTSEDESGA
EDRPNPNPVVDVEDLGRIVSCAKREKREKEQQEKSGLLRSSGKNGPGERRAMITPALREA
LTRQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEVILKEAIENHQSMIKQFKGVPGVKEERFEEGMMVKHCALS
LVGEPIMYPEINRFLALLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKK
IDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVK
GVTYCGESSASSLTMANVPWHEEVVHFVQDLVDLIPDYEIACEHEHSNCLLIAHKRFKVG
SEWWTWIDYDRFLELVREYEHSGGSATFGAQDYMARTPRWAVFGARERGFDPKDTRYQRK
NKSKDISGC
>G9KW45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mustela putorius furo|TrEMBL
WTNRFYVYVGLACGISLWICFQMVVGRRDKSSQEKSVPKASRDLGTDGSIPLQRKEVSVS
GVKIFYGSQTGTAKGFAASLAEAVTSLDLPVAVVDLKDYDPDDHLVEEVTSKNVCAFVVA
TYTDGRPPESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDK
WLWTLGAHRVVARGEGDCDVANSKHGSIEADFGAWKTKFLARLHTLEKGEKKPCDGSCRR
GQCESSAEEEPFESTSEDESGAEDRPNPNPVVDVEDLGRIVSCAKREKREKEQQEKSGLL
RSSGKNGPGERRAMITPALREALTRQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYG
IESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILKEAIENHQSMIKQFK
GVPGVKEERFEEGMMVKHCALSLVGEPIMYPEINRFLALLHECKISSFLVTNAQFPVEIR
NLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWN
VDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVHFVQDLVDLIPDY
EIACEHEHSNCLLIAHKRFKVGSEWWTWIDYDRFLELVREYEHSGGSATFGAQDYMARTP
RWAVFGARERGFDPKDTRYQRKNKSKDISG
>A0A395NMH1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma arundinaceum|TrEMBL
MDAGYRLQLEVMVADLVELWHAHRTPIILCALLLLAGLRVFLHTTAEREPLHALPKIYNK
EQLETSEKTIPQAQPVAETEKKSSGPRRIKGGLTRKPSQEDKTTVTDKTDRPSKVLVFFS
SVTTKTEKIAHDYVKALETFLDQKAKETEGKFLKPELLDLTEIDFEDYFVSPPKSAEGAA
YFYLFLIPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLIGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAYPVGMGDMKSDHVQRFVEWTTGVQEVISQVGQTGFLGEG
VPGSGDAVESDDEDAEADDGEVVFDDEESGDSKNSDDSRPLDDVEDLGKMIRPNKDGNET
TRKAPLAVDFTTYPSAGKKKGQAPIIKEMVAKNSPTYTALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDM
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLALLHKE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVRALDKRLQEKGLGYGIAAEHAHSCCVLLASNRFNVNGKWHTHIDYQKF
FELLEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAIVAREAPE
>A0A1J9RHD9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blastomyces percursus|TrEMBL
MAGEELGTVVRGLLALWHRYRAPILLLATVVFTGVWLTPRDSQPNTPNPDSFPASQHKNQ
NQNAKSELELVSSNDQAVADLPNRDRSRSFSVDNRPKQVKQPTNGPKRVRGIKPGKNGAK
HQIVGGGLHQDIVIQPLVFYASLTGTTEAYAKSFCDRLQKAAHPLLGNNSKTNLLTPELH
DLSYIELDDYFITAPKPPDSAPNTRFFYCILLPTYNIDSMINTFLGHLDDTHNDFRIDTS
ALSGLAGYSVFGFGDREGWPTEEEGFCSQAKAVDRWMAKLTGKRRAYPLGMVDVKGDNIQ
KVLNEWCDGLVDVIFDLMTSGGLGEGVPGSGDPVESDEEDIDDDGEESDDNGGNLRNGGK
KQQIMDLEDINKKAFSNLQPLPVDFTTQSLAQASNPPSQLEMVPTSSPTYAALTKQGYTI
VGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWKVDPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINKFLALLHSERISSFLVCNAQHPDELAALDRVTQLYVSIDASNRDTLRKIDRPLHRD
FWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAVGYADLVEKGLPCFVEVKGVTFC
GTSTSASAGLTMQNVPFYEEVVTFVVALNAELTRRGLGYGIAAEHKHSCCVLLASNRFYV
SDRWHTRIDYDKFFTLLDKEKNEGIPFRPEDYMRETEEWALWGNGGFDPKDTRVYTRGRN
KAKLNAALKEAQDIRVSAEG
>A0A7J6LR36|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus chesapeaki|TrEMBL
MLAGGGFYHAILSKHYPPLNRTVKIVYSSRSGTSHGAAKQLEDVLKTEGNRVICLPVEKY
AFEELCEEAYLILLLSTDTDGTPLPNAKELMDQLLDAVNDFRVDKNLLEKCRVAVIGFGS
EEYPAKYYCRVAKDCDDWLAKLGAARLTPLFCISDTRDIDKQVKRCIDQIRKAINRADKA
PEKEEVDLEDGGADSEGSDDSTSDTEDEAADDMEDNGVCGSDPKEMVTKKHRAALTREGY
KLVGSHSAVKLCRWTKHQVRGRGGCYKHSFYGIQSHQCMEATASLACANKCVFCWRHHRN
PVGKSWKWAQDPPDEVVDGWLNNHYGMIKQLKGVPGVTSDRFEQAKKVRHCALSLVGEPI
IYPEINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNPKDMKAVDRPLF
EDFWDRFIDSLTALKHKKQRTVYRMTLVKGYNISEAVEYAELLRLGHPHFVEIKSVTFCG
KGDGSAQMTMGNVPWFEEVVEFAQHMIDSSAWVKERYEIACTHRHSCTVLIAQKSFKVDG
IWHTWIDYDKFTDLALEYSKSGKPFSVEDYWAQTPSWAVYGAEEEGFDPDMKRHYRNGKT
PELGKQIRARQLAEAAKQQSANCCGGSSNDGGGCCGGGGGNCNKD
>A0A7K7RZE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nesospiza acunhae|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVALGISLWIVIQFTTTRTKRKQSHGSPSSPEG
TSDKQGNGCGPRQAQRIHVAGVKIFYGSQTGTAKRFAKALAEAVFSLNLPVEIINMEDYD
PEDGLVEETSSRNICVFLVATYTEGQPPESAVWFCKWLEEAASDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVARRVDRWLWMLSASRIMARAEGDCNVAQSKHGSIEADFEAWKDKFL
TRLQALCRGEKKPCRGKCKKGKCKSSGKQSQESSDREHGTSEQDNTEAEELFETSSEEEA
GGTDSVVDVEDLGNIMGHMKKAKVLLLEGVWNVHSVNHSGYHMVYFMCQFLKAKLSCLMI
CALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVF
CWRHHTNPVGTEWRWRMDQPEQILQEALEKHQNMIRQFKGVSGVKAARLEEALAVKHCAL
SLVGEPIMYPHINHLVRLLHQQGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLK
RIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEV
KGVTYCGESSASSLTMANVPWHGEVLSFVQELARLLPDYGIACEHEHSNCLLLAHSKFQV
DGEWRTWIDYGRFQELVRERERSGGARTFTAADYTARTPPWALFGAKERGFDPLDVRFQR
KNKARDTSGC
>A0A7K7MF71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brachypodius atriceps|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQLTTTRTKRKVTEPGTADKLG
NGCPLPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVSSLNLPVEVINMGDYDPEDGLA
EETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGLGNSA
YVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTLSKHGSIEADFEAWKTKFLTRLQVL
CKGEKKPCNGKCKKGKCKSSGKQSKESSDHEHGTSEHETTEAEELFETSSEEEAGGTDSV
IDVEDLGNIMGHMKKAKVLLLEGVWNVHGVSHSGYHLVYFVCQFLQAKLNCLVICPLFSG
YKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHT
NPVGTEWRWKMDQPEVILQEAIEKHQHMIKQFKGVSGVKAARLEEALAVKHCALSLVGEP
IMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRIDRPL
FKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYC
GESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVDGEWRT
WIDYSRFQELVREYERSGGSRTFTAAEYTARTPPWALFGAKERGFDPLDVRFQRKNKARD
ISGC
>A0A0Q0VPD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanolinea sp. SDB|TrEMBL
MLPEQCKPLLRQGYQFVRSDASAAVKPCLWCKKALKDQDMCYKHQFYGIESHRCVQMTPT
LRCNQRCLFCWRSFEHVFPGETECSPQEIVDAVPRLQKKALSGYKVSPYVREERFLEALD
PKHVAISLSGEPTLYSRLPELVTLFNEKGYTTFVVSNGTRPWVLEECSPFQLYVSLDAPE
RETYLKVCRPDEDYWDYIMQSLSLLGKKRSAIRITLVRGLNDHNPELYGRMIQDSGATYV
EVKGYMFLGYSRKRLTRDRMPPHSHVRSFAEQVAACTDYEVLDENQASRVVCLERRR
>A0A524C3Q2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MVSLTQDMPSELTEKLQSQGYHLLGERGAFKACQWQRKSLTSGKTCYKQRFYGIESHRCL
QMTPTVDKCTQQCQFCWRITPDDMGIQWDQMDVDPEGVLPPDRLLDETLMANLQSLGGYN
PEAGADVPEKKYREARNPKHVAISLAGEPTLYPFLSDFIEAIKKREMTSFLVTNGTRPDT
LRNLVLPTQLYVTLAAPNERVYKTLCRPSIADGWKRIQESQKLLSTLPCRTVNRLTMVEG
YNMTEVRSYADMILIGEPDFVEVKGYMFIGSSRDRLRAANSPSHRSIRAFSDKLETLTGY
HIADEQVESRVVLLSRDVDYDRINGV
>A0A7J4TPY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDPQLKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVSSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTRGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDAVCRPKWNTHAWEKFEETIDLLPSLDTRIVARHTMMKGINMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSIENMPSHDDIMDFSNKIAPLVNREVLSDSRPSRVALV
GREITPIPIPKATMFFPEDLGIAPSVKHLPMAG
>A0A7J4RCL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPIELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLVQN
>A0A0F8F0C6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. 2.H.T.1A.6|TrEMBL
MPLEEKKEEKEDSGEKFPEVQGENRDEEQTSLPFYIPDFATLLKKQGYALAGRHSAVKTC
LWLRHAMNDQGFCYKSRFYGVQSHRCLQMTPTLICNQRCLFCWRPTEVPVPAPGEWDSPE
KIVEESIACQRKLITGFGGSPNALRERWLEGNEPNNVAISLSGEPTFYPYLPELIEEYKK
RGFTTFLVTNGTVPSMLAKINPSQLYMSLDAPDLETYLRVCQPKSPALWDRINESLDFMK
EKSSRTVIRTTLVKGENMFNPEGYARLIKKASPDFVEIKAYMHLGFSRLRLDRSAMPTHA
EVLEFSKELAKHLGYEITDESDISRVVLLSKDGKKSPVKNISYLD
>A0A8J2T2N8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces bailii (strain CLIB 213 / ATCC 58445 / CBS 680 / BCRC 21525 / NBRC 1098 / NCYC 1416 / NRRL Y-2227)|TrEMBL
MTFFFPFSLQKFRAHRTRRHKSQDFVISLHFFNRLISEEFIRLALSLMIRLNGATAAGTF
LLTMVYLWLGGRVTIALAIIVSYAILHKEYNVSNEQGQEKTPAKTEKKEKKHTCCGGKGG
ANCCSSKAGGAGGSGHACRCSSKNKAQEKKEEAKEEKKGLEAGSFPVAVDFTQAFKPQKK
KSTKQPKVFSKPMPTKKKTASRDDDFKKSAMTVSNGTLLNSQIYVFYCTLQGTAERYANR
VMAQLCTMRDLKQRPTLINLDEVTDLDDYFVSVPSENSLYILVLPSYDTDCPLDFFLQTL
EENFNDFRIDKYPLRKLVGYSILGIGDTETWPEKFCYQAKKTDHWIARLGGRRIFPIGEV
CVKTGGEPKVNEWIDLFCETMKDDEPILYEYDESVEDDGTENDEMVDLEDMGNAEGNNST
VIKQMVAKDSPTYKTLTKQGYSVVGSHSGVKICRWTKSDLRGRGSCYKHSLFNIVSSRCM
ELTPSLACSSKCVFCWRHGSNPVSKNWRWEVDEPDYILENALKSHYSKIKQMRGVPGVVA
ERFAKAFQVRHCALSLVGEPIMYPYINRFIGLLHEKGISSFLVCNAQHPEALANLCRVTQ
LYVSIDASTKGELKKIDRPLYKDFWERMLQCLDILNTTQSHQRTVFRLTLVKGFNMGEVM
SYADLVQRGKPCFIEVKGATFAGSSDGNGNPLTMQNIPFYEEIKTFVKKFAAELQRRGLG
YDVSAEHAHSNCVLIASTKFKMNDEWYTHIDFDKFFDLLASGQDFTPLDYVAKTPEWALF
GNGGFAPGDTRFYRKGKKKIPETEKLSSTYSAAFVNSTQQEPVRGETAASFEIA
>A0A5N6FI05|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Petromyces alliaceus|TrEMBL
MAEVSFIEGLLTFWHSYRLPILIAVTSVAIVLRVYQKSQPKSKAVSASSIPPSPRSQSPD
KFEKVCASNSEKLVVTEKSVPNSAVGNESAPKVASGPKRVSGKKPLKVAGRGRGSDQGPP
VSFIQPIIFFASLTGTTERYAQVLLEDLRAAAKERADPENRDRGLLPPQIHDLSYIDFDD
YFTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYS
VFGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKNDAESALKEWSRGL
QEILLDILNNGGLGEGVPGSGDPLESDEEDLDDEENDGKRSKRRNGQDVVDLEDIKMGSS
DGQAGSGPVPVDFTTTGNSVAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPD
LIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHN
EHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDIL
REKRHFQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCLIEIKGVTYCGTSTSAGAGLTM
QNVPFYEEIQEFVLALDKELQGRGLDYGIAAEHAHSCCVLLASKRFYVNGKWHSRIDYDR
FFELLEKEKADGTPFRPEDYMKETEEWALWGNGGFDPNDERVYRKGKKKALQAPTE
>A0A8J7ZZ39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. R1-2|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A7C0X862|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MKEELKIRLEKQGYAIVGEHSAVKLCHWLRQSLLHNRVCYKQVFYGIQSHRCLQMTPAVN
QCTHMCLFCWRHQGFTEKTFKHVDDPEFILEESLKAQRRLITGFKGDPRCNQEKWIEANH
PNMVACSLSGEPTLYPYLGEFFELCHRRGMTTFLVTNGTTPEVLEKLDPLPKQLYVSIVA
PTKEIYKKLCSPLIERGWEKIKETLEILPSLDTRTVIRHTLVRNWNMKHIKEYAKLDEIA
SPMFIEAKGYVFVGASRKRMSIENMPSNSEVVSFAQELSKTLGYEVAMEKEDSRVALLIR
DHSIETKIT
>A0A2Y9PD02|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Delphinapterus leucas|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGKAKGFATVLAEAVSSLDLPVAVINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKNVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPRSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKEQQEGETSLIRSTVKNEAGERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQAEMILKEAIENHQNVMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKIMT
RLGKKSVFSSSSPAPLLEPWRQQLEVGMESSSPAAICLGSARAAPGQDK
>A0A8H5NJT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium phyllophilum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLARPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRRFLKPELQDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFDGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYAKLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A367JM58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhizopus azygosporus|TrEMBL
MSNFFNSLIYNFSNILSIGPEPPREGEEQCGTGCCKEQQSNNEGCCQGSGNSNGCCKDNN
QILEIESVKILYSSLTGTAKTFANEVEEKLKSTKFVKIQKLETMDITDYDNDNLLNETSV
CIFILATYNVEGPLDWFSNWLHDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVAAAN
IDKWLGRLGATRIYPLGECDKNADQKAQFDVWSNGFISELQDKHTLEFAPTNIAYQSDDD
DEEAEEAEATGLEDEMVDLEDMGKMATKIKAAKAKRAEEEEDFEDSKAKAKRAIGEDAKK
QEKPQAREMVSPMILKNLTKQGYKVVGSHSGVKICRWTKSALRGRGFCYKHAFYGIQSHL
CMETTPSLACANKCVFCWRHHTNPVGTTWRWKVDDPKFILDGAMENHYKMIKQLKGVPGV
KAERFQEAFTIRHCALSLVGEPIFYPHINDFVNMLHERNISSFLVTNAQFPDKIAEMVPV
TQLYVSVDAATKESLKKIDRPLFRDFWERFLNCLEQLSLKGQRTVYRMTLVKGHNTEEID
GYVELIRRGKPSFIEVKGVTYCGYSGASDLTMANVPFHVEVIDFCRKLVSKLDGEYEISA
EHAHSCSLLIAHKSFKVNGEWYTHIDYPKFFELVKSGKPFTSLDYMAKTPEWAVFGHEAA
GFDPDETRFYRKNRKNVEPPVIKTEA
>A0A8H5RNH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sp. NRRL 25303|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVIEEKTPTIEPVEEKKSVKSQGPRRIKGGIARKSSKIKEEEKDITRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDGLSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHDERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHS
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A091KN55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chlamydotis macqueenii|TrEMBL
LDVSSMDTWNFFHTCLVSLWLHRFYVYSAVALGISLWIIVQFFTAKTKKKGEKSHGNPAS
SEGTGDKLINGYATLQAKEVCVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLPVEVINMG
DYDPDDCLAEETTSRNVCVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKTYLKGLRY
AVFGLGNSVYVDHYNTAGRNTDRWLWMLGASRIMTRAEGDCNVAQSKHGSIEADFEAWKA
KFLSRLQALCRGKKKPCSGKCKKGKCKSSGKQSKESSDHEHQNASEYENPEAEELFETSS
EEEADAEEAGGTNSVVDVEDLGDIMSHMKKAKRECELQEGDGTSLTGERSGRNEEGEKRE
MITPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSL
ACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQQAIENHQNLIKQFKG
>F7XMG2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5)|TrEMBL
MNYKEQIFNIPDFETLLKKQGYRSAGNHSAVKTCLWLGRSVKGEGSCYKSKFYGINSHQC
MQMTPTMMCNQKCLHCWRPVEVDVRPPEKWDSPVEIVGSAIKSHKKLISGFGDSGKRELW
MQANQPKHAAISLAGEPTLYPYLPELVDEFSRNGITTFVVTNGTNPEMVERINPTQLYMS
LDAPDRETYNSVCSPRSSDYWENIKMSLEILGRKTERTAVRVTLIKGVNMFDPAGYARLL
EMADPDFVELKAYMHLGFSRRRLPRDAMPSHDEVFSFAHKVANEMGYEIIDDVETSRVVL
LSKSEQESYLF
>A0A5Q0UIV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicrobium sp. LC1Hm|TrEMBL
MVAAIPSSTTSVRDPSTYFVSVPRSAGARIRVIPDGRMFEAPGSLSPVMSESDGPKQVDD
PDYHSENHTAAQTCGWTANALRGEGKCYKYIFYGIESHRCIQMTPVVKCNERCVFCWRDH
AGHAYELGDVEWDDPSAVADASLELQKKLLSGFGGNEKVPRERFEEAMEPRHVAISLDGE
PSLYPYLPELIEEFHDRDITTFLVSNGTNPDVLERCDPTQLYVSVDAPDRKTFDDTVKAV
EDGAWDSLIDTLDVLADKDDTRTVIRTTLVKGHNMHHPAWYAAMCQRADADYVEMKAYMH
VGHSRGRLDRDSMPSHDEVRAFTERVGQFLPEHDTLKEVEESHVTLLAEEEQTWVPKLEK
GSEFWERDPVVSY
>A0A5J5LC71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. CBA1129|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRGTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVRAFTQEMGEYLPNHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWEQDALVDY
>A0A832SNU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp|TrEMBL
MIISDEQRKNLEKKGYRFAGNFGHAGNKICHWTRKSIVDDGVCYKEQFYGIKSHRCLQMS
PAIPYCQHKCLFCWRDTDITKTSWDSDDYDDPRTIIEDCIANQRQLLCGYFGNDNANPVK
LEECLVPNNAAMSLAGEPLLYPEINQLIHEFKRLDFTTFLVSNGENPERIAALEEEEPTQ
LYVSLDAPDEETYKRTCLPQVSDGWQKLNESLELLSTLDTRKVLRITSVKDLNMNNPEEY
AKIISKCDIDYVEIKAYMFVGDSRERLEWENMPKSVDIREFANSVAEHAGLDVIDEVEKS
RVLLLGDKKPVKYNK
>A0A150IPJ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MEKVWSILKRQKYRIVGAHSAVKICHWTKKSLTEDRVCYKQKFYGIESHRCLQMTPSVAW
CTHKCLFCWRPIEYNEDNPSKYDDPETIIEGCIEAQRELLSGYHGFLEKVDINRLKEAEN
PTNVAISLAGEPTLYPDLSGLIDGFRKRNFSTFLVTNGTTPEVLASMSTYPDNLYITLPA
PTKDTYEHICNPQIRDGWEKLNESLELLPKIKTKRRILRLTLVKDFNMNEIDQYSKLIEK
ANPDFIEAKAYMYVGYSRKRLEVENMPMFDEIIDFCKELEEKTGYKSIDSASESRVVLLS
RD
>A0A497S0K3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MIPYKIQEILKNRHYHIVGKHSAVKLCLWTKKSILDEGFCYKEKFYGIRSHRCLQMSPAV
IWCTHRCIHCWRYMHNIDLKFDNTKIDEPEFIVENSINAQRILLSGYGGIPDRINLKKYE
ESKIPNQAAISLSGEPTLYPRISELIEEFHKRGFTTFLVTNGTLPERIRNLDELPTQLYL
SLNAPDEETYKIVCRPLIRDGWSRITETLEVLKSIETRSVIRITLIKDVNDRDIDGYGRL
IERAEPDFVEVKAYMFVGESRRRLSLENMPSFQDVRKFSEELSVEIGYDIRDYKEDSRVV
LLA
>A0A3P6BMK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica campestris|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLNPSSRRGKIFFISQTGTSKSL
AQRLHKLLESNGIAFDLVDPASYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSES
AEDFRVGSLLLSCCRFGVFGVGSRAYGDEYNAVAKELSRRMVGLGGAEMVPVGEGDVDDG
ELDRAFNEWCDGVIRVLKGGSAQAREANEITQNGVVESEEEYIDTTDEEEEEDSNDIVDL
EDIAGKAPSRKNGVVKVTKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVKG
ALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIST
FLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFSDFWERFIDSLKALQEKQQ
RTVYRLTLVKGWNTEELEAYFNLFNIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADVK
AFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPFT
SRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>A0A7C8QUW7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Orbilia oligospora|TrEMBL
MAEIFKSRSLDLIELWHTIRIPLIIAIGVLYITIRLRSILRARTPVLTAPPSPSKLEPQL
CAEPDGTVILPEKFEATSPSNKRRKLSPAKNVPKRITGGEARKKKPVKSNADAPPAIERV
WETTQSNGKSIQVFIFYSSLTGSTAKYAEKLSNDLFSEPLHIPTPTPPSVDNAEPEPAVE
KATFLPPIVENLDYLDLDDYFISPATVKGPNTTSVYLLLIPTYEITSPVDAFLEHLSETH
NDFRIDTRPLRSLAGFSVFGFGDKEGWPTEEGRGGGVFCGQAKEADRWMSKLTGGKRVFP
IGMGDVKGDALDSMDEWRKHLEIALNDLATGEILPESTGVDSEDEEDVAQDAATTEPLVD
VEDIGNSIRSSKPPKSKKSSAPLAVDFTTTNPRTSKLKEMVPTSSPTHSALTKQGYTIVG
SHSGVKLCRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVST
TWNWVVDPPEMILSGAMEGHYKKIKILKGVPGIRADRFAEAFRIRHCALSLVGEPIFYPH
INEFLSMLHARHISSFLVCNAQHPDQLARLKYVTQLYVSIDASNKESLRRIDRPLHRDFW
ERFMKCLDIIKAKKDRMRTVYRLTLVKGFNIEDEVEGYADLVEKGLPAFVEIKGVTYCGT
STSVGAGLSMQNVPFYEEVCEFVKRLNEALQKRGLEYGIAAEHAHSCCILIASNDYFIDG
RWHTVIDYQKFFELLEEGKEFGPLDYVGPPTEEWAVWGNGGFNPADERVYKKGKHKGKTA
EEVAAELAAEAAEAESGCG
>A0A7C5U0J2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MRLTGMILMETIKRLKNEYLKQGYKFIGEYSLLKPCYWLKASLISKGKNFCYKQKFYGIP
SHRCLQFSPTITCTHECIYCWRVQASDIGIKWNEQNLPTWDEPEKIVLNGLKMQREVLSG
FKGNRNVDRNMLEEAFRPIHAAISLVGEPTLYPYIDDLIYELFKYNFKTVFLVSNGTRPD
VLGNLCNEPSQLYISLSAPDYETYKKVCRPKIPNGWENIMQSIELIKSFSCPTVIRLTLV
RELNLKKVEDYAKIIEKANPTYVEPKAAMSLGGFQYRLSSTHMPSFEEILEFSKKISELT
SLKIIDTSESSRIVLLSRLDKPIKLI
>A0A420QJK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A818BGL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria socialis|TrEMBL
MAVDINILAAGSGLTGLILYFVTGAQWSSWHLFTLPIFTFVFIVFTSLSIKKRFKDSSKS
QPSTKNNSDEKNGITIIFGSLKGNSRTFAKLTSEKLSNEFTRQVILQDLNDITDPEEFLQ
IQAKQQRTLLIFISTYEDATPPPSAKWFLLYLQDAAIDFRFSKNELGKLTYAIFGCGNSL
YNENFNKVATEIDRCLSELGAKKLLATELADENTGKSIYGGLEGHYSKWSSKLISALESK
ATGKCDCTANEDSATTCCKSTSTNGHSKETNGTNEVLIESDDDDEGGCKDGEEDVMDLED
MGDYIETSLPTKAKGPPKEMVTPLIRKSLEKQGYKIIGSHSGVKLCRWTKSMLRGRGGCY
KHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIGNHYK
MINTFKGVPGVLPSRLAEGMQIRHCALSLVGEPIMYPHINELIDLLHAKKISSFLVTNAQ
FPDEIRVLQPVTQLYVSVDAGTKESLKKIDRPLFRDFWERYLDSLRALKAKGQRTVYRLT
LVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSDASNLTMANVPWHEEVVTFVRLLC
ERLPQFDLACEHEHSNCLLLANTKFRIDDKWHTWIDYEKFHECVARHKATSGAETFTSLD
YMAVTPDWAVIGSNERGFDPIDTRWYRKSTAKKNLSGC
>A0A7J2YL66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrososphaeria archaeon|TrEMBL
MSTIPAHRLSRDEIKALEKFKKAGYRIVGRHSAVKVCHWTKTALRGGKFCYKRWYGIRSH
RCVQMTPTLQYCNMMCIFCWRFHSINRVSPYSGDWDEPKAILDGCIAAQRELLSGFKGNP
KVTAQRFNEAMDPKHVAISLDGEPTLYPYISDLIKEAKLRGMTTFLVTNGTMPEVLKELE
TLPTNLYISLYGPDEETHKQVTRPLITDSWQRTIKSLELMSSLDCRKVVRLTLVKNYTMK
GAEKYASLIKLAMPEFVECKAYMHVGESQRRLPREAMPSMEEVSNFAEGLNRSLGYVLVT
EDSDSRVVLLARPDVELSKIASF
>A0A497HQ33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MPVLPHVREMLRKQHYYLVGEHGAVKLCHWLKKKLTEGRACYKENFYGINSHRCLQMTPA
VDICNHACIYCWRYQAPQEWPLNVRSSGGWDDPRELVEGLIEGQRALLTGYKGNPKTNLR
LWEEAQNPNQAAISLSGEPTLYPHLSELIEEFHRRGFTTFLVTNGTMPEVLERLDPLPTQ
LYISVDAPNERIYKSLCRPYIRDGWERIKKTLELLPSLDTRKVVRHTLVEGWNLGYVKDY
ARLDKVASPEFVEAKAYMFVGYSRQRMRIDNMPSFERIKSFAEELSRELSYTYHAEQPPS
RVSLLISDPKRIKVRLDN
>K7CD59|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pan troglodytes|TrEMBL
MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
QALQKGERKKSCGSHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
GGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDSERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHRKF
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A061HDC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Blumeria graminis f. sp. tritici 96224|TrEMBL
MSYNDTESLRHIWLSGIENAVGNWHNHRIFLLLSGFTLLIILKLLFKLQQLRLNSINPKI
LPKNLPNTSPLKKETHNERKSAGAKGPRRIIGEIKRRKLLQEQDIRSGSVQILVFYSSLT
GTTEQTAKLFTCDLTQTCRNLGAPNYATFHEPKLVDLSAIDFDEYFLNIPKDGADCQYFY
LLILPTYNIDTILDGFIEHLRETHHDFRINTSPLSGLLGYSVFGFGDVEGWPTEKDGFCS
QARDTDKWMAKLTGGKRAFPLGMGDIKKDGYARLDDWKKGVEDVLSYMVKTGNLGEGVLG
SGDAVESDEDTDEDQILDQRNPTQNRLLVQPSSTLNDLEDINVKPASDKTSLSLQEIDFT
TKGNKPNSMIKEMVPKNSPTYAALTKQGYSIIGSHSGVKICRWTKSALRGRGSCYKYSFY
GIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWTVDPPELIFDGAKAGHYQKIKMM
RGVPGVRAERFTEALSIRHCALSLVGEPIFYPHINKFLALLHAERISSFLVCNAQHPDQL
AALGTVTQLYVSIDASNRESLRKIDRPLHRDFWERFNRCLDILRERRFEQRTVFRLTLVK
GFNIEDEVMGYADLVEKSLPCFIEVKGVTYCGTSASVGAALTMQNVPFYEEVCTFVKALD
LELRNRKLGYGIAAEHAHSCCILIASERFKVGGKWHTRIDYEKFFQCLNRRQPFRPEDYM
GPETPDWATWGRGGFDPRDERVYRKGKNKGLRPEIQVAPMEN
>A0A3R7K4K6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phytophthora kernoviae|TrEMBL
MPLWSPAASAGVSLLLMATVTVGVLYYLSTHPPTSSNEAASAASPKRKTKAQRKKINKVN
TKDTNEPKPMPVRILYGTQTGASKTMAETLQKTLFALNISGFHFQTSVVSMKDYDQDNLE
QETIVVAVLSTWTHGEPPEDARMFCKWIQDMTQDFRVSKSWLSGVQHAVFGLGNAEYDED
YGTAAKNLENDLSDLGSPGLVALGLGDDNVDQFKQFDTWMDNLVAAMCEYSSERAVAALA
KSDSPVKNAQSNKKEWLSQKEFRRQKRAKKAQEAVANGESVELNEEDMMNEQFLVDEFSD
DEEQSTQNANDDSGMVDVEDIGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAV
KLCRWTKHQLRGRGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWK
TDDAETLVKGSIERHQGMIKELKGLPGLIPARWDEAFTVRHCALSLVGEAIMYPQINEFC
KQLHQRHISSFLVTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLA
CLEELKHKGQRTVYRLTLVKSYNMEELDNYAELINIGQPDFIEVKAVTYCGKSDGSDLTM
KNVPWHEEVRGFCSALCDRVSGDYALASEHSHSNCVLIAKKKFCREGVWHTWIDYERFHE
LVTKFYEDGTTFTADDYTAPTPFWAMYDSEEQGFDPVETRFRRTKDGKVVEFQYQSTESG
CG
>A0A2E6U8B7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLDLLYESVRAQRRLLTGYGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYTRLAEYMDLCHQHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWEQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAAIDR
RADPDWIEAKGYVYVGHSREHLSIDNMPSHEDILTFSESLAPQVDMRILSESRPSRVALI
GNEMIPIPIPEATMHFPEDLGTAPPVKKLKLADLS
>A0A0D2XW74|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936)|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEGKKNVKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A7L4Q146|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon|TrEMBL
MLSPPCKALRSQGYQFVAPDSSAAVKPCLWCKRSLRGGEKCYKHQFYGVESHRCVQMTPT
LRCNHRCLFCWRSFEHEYPGERECTPDEIVGRIPDLQKRALSGYKVSPYVTAERFSEALT
PKHVAISLSGEPTLYPHLPELIDLLTREGYSTFLVSNGTRPWVIRRCKPFQTYISLPAPD
RDSYLRICRPEDDYWELIGESISLLGTRRSAIRITLVQGLNTFAPEKYAAILQDSGAHFV
EVKGYMYLGYSRKRLGRENMPGHEEVRAFAGRIAGRCDYRITDENPGSRVVLLERNV
>A0A113SD64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium berghei|TrEMBL
MIKKREDELVLPHNEVGNINIYSIQKKAKINFTLIYGSESITSYKEGKEFLNELIVFFND
ILNHFNIISTITKGDEKNDTIFEKSINNEINNIEAYMFEYFRSKLLKTKKKNKDGNSEKK
CKNEKADNESPKCNNEVKDIFDNLKKYEKNIIKCGNTHFNNYLNCSIENNISEINFDFVN
GNEFDNYTFFENSENNDLNILFMFISTYNFGAFPANCYKLEDALTDLVNDFRIEKNYLKN
IFYSCVGFGNKEYGNAYFCTPIKKCDKFLSSLGANKLEKTLKLCSTMDNEKEIIQWKSNL
LTKICLSLFLYNFNYTKFSNNFFHYSNRKNYNTLKYYCTYFCKKKEDVKSMAINNDRENK
QTTKSSGNNNINKCECISNDMSLKYLDTPKEPNNDQNKLINNINGHISFFTSNTDVNSTE
KCGCTSNNCSNGNDKYINKKKIINNNFETPIINECCKKEYDKNIENDELINSDFNSESMS
ENIDEINCNSSEELEDLLSNKIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQLRG
RGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPIGTKWRWNKDEANFIVDEAV
KKHKNMIKELKGVQCVINERFENAKNIRHCALSLVGEPIMYPDINKLIDELHKKNISTFL
VTNAQFPNELKKLKKVTQLYISIDAPNKEALKNIDRPLFKDYWDRYLKCIKILKGKKERT
VFRFTLVKEYNMMSDEISSYAKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVY
QFAFHLINSKRYISDIYEISCEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVKQNAN
FTAIDYCEETPEWAVIGAPECGFNPSDQRVYTKGKNKNKKNINTMEVKT
>A0A078KAW8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium yoelii|TrEMBL
MITKREDEIVLPPNEVANINIYSIQKKAKINITLIYGSENITSYNAGKTFLNELINFFND
ILNNFNIINTITKGDKKNDRNFEGSISNEINNIEDYMFKYFRSKLLKKNKDGNSEKNWKN
ESAKLKNESAKLKNEAKDNFDNLKKYEKNIIKCGNTHFNNYLNCSIKNNVSEINFSLVNG
NEFDSYTFFENSENNDLNFLFMFISTYNFGAFPANCYKLEDVLTDLINDFRIEKNYLKNI
FYSCVGFGNKEYGNTYFCTPIKKCDKFLSSLGANKLEKTIKLCSTMDNEEEIIQWKSNLL
TKICLSLFLYNFNYTKFSNNFFHYSNRKNYNTLKYYCTYFCKKNEDVKNRIINDKQNEQT
TNLLNNNNIKKGDSINNDQNKLINNINGHISLFTSNIDGNSDEKCGCTSNNCLNGNDKYI
NKKKIINNNFETPIVNECCKKEYDKNDELINSDFNSESMSENNDEINCNSSEELEDLLSN
KIKDMLTDNQRTKLTKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMEA
TPSLACANKCVFCWRHHKNPVGTKWRWNKDEADFIVSEAVKKHKNMIKELKGVQNVINER
FENAKNIKHCALSLVGEPIMYPDINNLIDELHKKNISTFLVTNAQFPNELKKLKKVTQLY
ISIDAPNKEALKNIDRPLFKDYWDRYLKCIKVLKEKKERTVFRFTLVKEYNMMSDEISSY
AKLIEYGYPDFIEIKAVTYCGSSEGYQLTMKNIPWHEEVYQFAFHLINSKRSISDIYEIS
CEHKHSCSILIAKKIFKINNKWHTWINYEKFQSLVKQNANFTAIDYCEETPEWAVIGAPE
CGFNPSDQRVYTKGKNKNKNNINTMEIKT
>A0A094CQY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-4516|TrEMBL
MANNDYLGADIASDAMENYIMVLWHTYRIPILLTVFVVLLITRTVLYLKVGREKIIYTPP
ATPSEKAPVAAVSQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLRDQPANKDVKFQV
LVFFSTLAGSTERTAQALTTKLGETLKAGAEKSQYEFLEPVSHDLAELEDYDEYFLGLPK
SEDGGPDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLDEWRQGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEDASDGETEVQSDGAVKLKRKSKKKAESSMDDVEDIGRI
LQKGQAESEDQDDDDSGAIDFTTYGKKTPKPVAALKEMVPKGSPTYNALTKQGYTIVGSH
SGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTW
RWVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLN
EFTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWER
FQRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSS
SGAAGLTMQNVPFYEEVCAFVLALTAALEKRGLKYGIAAEHAHSCCILIASDRFKKEGKW
HTRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVE
GEEGEKEVEAKEEKKVLVEI
>A0A1S3UBM4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Vigna radiata var. radiata|TrEMBL
MAIARLVRQAKRPHGLWVKMAAVTVMGLCFIFVWGVFSSSSSSVTSQRESFEDIAEPVSS
SSSHKPQKLRDESKKGGESEKKSKSNGNGSSHSSATRPHSEQHKGKDNKKEKKHVQHKED
KEKGNHQGSEEPQPQHGQEEKEKENVKEEVEGEEEKVDHESDVDVDVDADGGSDLSESVD
KDDSKVVEDAEELRKKSKVKVKGPLFDPNASYSWKLCSSRSKHNYIPCIDIEVGGGKVTS
YRHTERSCPRTPLMCLVPLPHEGYGSPLPWPESKLKILYKNVAHPKLAAYIKRHNWLMES
EEYLTFPQNQSEFKGGIHHYLESIEEMVPDIEWGKNIRVVLDIGCTDSSFAAALLDKDVL
TLSLGLKNDLVDLAQVALERGFPAVISPFNRRRLPFPSQVFDAIHCAGCSIPWHSNGGKL
LLEMNRILRPGGYFIMSTKHDSIEEEEAMTTLTASICWNVLAHKSDDVGEVGVKIYQKPE
GNDIYELRRKKIPPLCKENENPDAVWYVPMKTCLHPIPSGIEQHGAEWPEEWPKRLETYP
DWVNNKEKVVADTNHWNAVVNKSYISGLGINWTSIRNVMDMKSIYGGLAVALSQQKVWVM
NVVPVHAPDTLPIIFERGLVGMYHDWCESFGTYPRTYDLLHADHLFSRLKNRCKQPVSIV
VEMDRITRPGGWTIIRDKVEILNPLEEILKSMQWEIRMTFAQDKEGILCAQKTFWRPIPL
LHIFSHKSSFSTATMSISNSLSSVPARLTLLALFSATTFYCLYKSRRLRYLKLSLNPNPK
PKPKIIFLSETGTSKTLALRLHRLLASNGVAFDVVDSRHYEPEDLPKETLLXLVASTWQD
GAPPDASRFFATWLAEASADFRAGSLLLSSCRVAVFGVGSRAYGESFNAVAKGLATHLRA
LGAKEVVPLCEGDVDGGDLDKVFDRWCEKVLAVLKGGGVXECDDGDGGGALDYGVYSSSE
EESDVESEIVDLEDIAGKAPSRRKTLASGEESNGKLSGRKEMVTPVIRANLVKQGYKIIG
SHSGVKICRWTKAQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGK
SWQWEMDDPVEIVNSAVDLHTNMVKQMKGVPGVTLERLNEGLSPRHCALSLVGEPIMYPE
INALVDELHKRRISTFLVTNAQFPEKIKSLKPITQLYVSVDAATKDSLKAIDRPLFGDFW
ERFIDSLTALREKHQRTVYRLTLVKGWNTEDVDAYSKLFSIGDPDFVEIKGVTYCGTSTT
SKITMENVPWHADVKAFSEALALKSQGEYEVACEHAHSCCVLLAKTNKFKIDGRWYTWID
YEKFHDLVASGKTFDSRDYMTATPSWAIYGSKEGGFDPGQLRYKKERHHKSSHNQSG
>A0A091JME0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Egretta garzetta|TrEMBL
LDVSMDTWNFVYTCLVSLWLHRFYVYSAIAFGISIWIVIQFTTTKTKKKGEKSNGNPASS
EETEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVIALNLPVEVSSLGD
YDPDDCLAEETSSRSICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKAYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLSASRILTRAEGDCNVAQSKHGSIEADFEAWKAK
FLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDREHGASEYENAEAEEFETSSEEE
ADAEEIGGTNSVIDVEDLGNIMSYMKKAKREWEHEEGDVGTSLTGETTGWKEEGAKREMI
TPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMT
AKHCALSLVGEPIMYPEINRFVRLLHQHGISSFLVTNAQFPDEIRNLEPVTQLYVSVDAS
TKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGK
PDFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADHIPDYEIACEHEHSNCLLIA
HKKVRL
>U1GA11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Endocarpon pusillum (strain Z07020 / HMAS-L-300199)|TrEMBL
MDMEERHLWPVLVADWIDRILSLWHTHRTPVIAGVLTALLLLRAYLRRTTKFKDPNSSSN
PSSPLPLKDDEKPPWSSQVPEKLETVSSRERRVSLQHSAGPKLVTGRRPLKERKNENTKQ
GGGQLRVQPLVFYCSLSGKTAQLAQNVVSKLNASLPPDGSVLPSELHDISYIDLDDFFIS
GPKVRPSAGGVRYFYCLLIPSYNIDTIMTNFLSHLDETHNDFRIDTAPLSSLLGYSVFGT
GDKEGWPSEVEGFCSQAIEVDRWMAKLTGRKRAYPLGLGDVKGNLQKSLDEWTVGIQYTL
YDLSITGTLGEGVPGSGADLESADEEEADFPDSGRQKRQKTEQVADLEDVRGPINGPLPI
DFTTTTSYLSSAPTLREMVPKTSPTYAALTKQGYTIIGSHSGVKICRWTKSALRGRGSCY
KNSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQMIFDGAKKGHYQ
KIKMLKGVPGVRAERFEEAMRIKHCALSLVGEPIFYPRINEFVGLLHDEGISSFLVCNAQ
HPDQLASLQRVTQLYVSIDASNRDSLRRIDRPLHRDFWERFQKCLDIIREKRFVQRTVFR
LTLVKGFNIEEEVEGYADLVQKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVVAF
VEALNAALARRGLEYGIAAEHAHSCCALLASDRFFIDGRWNTIIDYSRFFELLERGEDFS
PEDYCLPTPEWALWGKGGFDPADQRVDRKGRPKVAEVVGYPGHAAQTIAQPA
>B0Y8J1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)|TrEMBL
MAEHSTAEGLLVFWHSYRLLFLVALSTVFVGLRFYRKLQSRTKTTASSSVPPSPRSQSPE
KTEKGVSRESSNKATAQKAEQQPALANGSAKPTSGPKRVTGKKSSKVAGRRGQTEDAEPL
AFIQPIIFYASLTGNTERYAKVLLDELRVAAQKRADLRDRERGLLPPQIYDLSYVDLDDY
FTSAPKPPPTSPGTRYVYCLLIPTYNIDSILNTFLDHLNETHNDFRIDTGPLSSLAGYSV
FGFGDKEGWPTEEEGFCSQAKELDKWMAKLTGRKRAYPLGLGDVKSDAETSLKEWSLGLQ
DILFDILENGGLGEGVPGSGDPVESDEELDDEDTDKDNTQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSVQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWKVDSPELIFQGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDLLHGEHISSFLVC
NAQHPDQLHALRRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNIDDEVIGYADLVEKALPCFVEIKGVTFCGTSTTAGVGLTMQNVPFYEEV
AQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVNGKWHTRIDYDRFFELLEREK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKHMQITAEP
>A0A428PYI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium sp. AF-8|TrEMBL
MDWANYSAPSRLDSFVEDLVDVWHIHRTPILVAALVILGTLRIYLTFIGQKTELVALPEA
YKEPPKPKAVVEAKTPAVETIDEKKDVKPQGPRRIKGGIAKKPFKKNEEEKDLTRPIMVL
IFFSSITTKTDKIAQAYLKELEAKQEELAKQSGRQFLKPELKDLTEIDFDDYFIAPPKVH
GDVDFFYTFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGLLGYSVFGFGDKENWPT
EGEGFCFQAKEIDKWMAKLTSRKRAYPVGMGDMKSDHEERLQEWTKGVEEVIEHVARTGN
LGEGLPGSGAAEESDVEDIAEDEDDGEVLFEDDDTSDAKKNGRPLDDVEDLGRMIRKDDG
STVQKAPLAVDFTTYSSTKKMVPQGPKEMVAKNSPTYAALTKQGYAIVGSHSGVKTCRWT
KSALRGRGSCYKFSFYGIHSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDL
IFEGVKTNHYKKIKMLRGMPGVRAERFAEAMQIRHCALSLVGEPIFYPHINEFLGMLHAE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDAADKESLRKIDRPLHRDFWERFQRCLDILR
EKRNRHRTVFRLTLVKGFNVEEEAEGYARLVEKGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALENRLKEKGLNYGIAAEHAHSCCILLASDRFNVNGKWHTRIDYKKF
FDLLEERGPDGDWTPEDYMDPEPNPEWSNWGNGGFDPRDDRVDRKGRKIEAS
>A0A076LF40|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanocaldococcus bathoardescens|TrEMBL
MIPEEIYKILRKQRYQIDNHTAVKLCGWVRKKMLEDKSCYKSKFYGIETHRCIQCTPSVI
WCQQNCIFCWRVLPSDINVSEIKEPKWDEPEVVYEKILAMHKRIIMGYAGVLDRVGEKKF
KEALEPKHVAISLSGEPALYPYLDELIKIFHKNGFTTFVVSNGILTDVIEKIEPTQLYIS
LDAYDLDSYRRICGGKKEYWENILNTLDILKEKKRSCIRTTLIRGCNDDILKFVKLYERA
DVNFIELKSYMHVGYSRRRLNKEDMLQYDEILKLAKILEENSSYKLIDDSEDSRVALLQN
ENRKINPKIFE
>A0A533U5B4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon|TrEMBL
MSCSGETIEPDNEIIQITPKLVSQLKKAKYGVSDHSTVELCHWTKKSFKGEGDCYKMKFY
GITTHRCMEFSPAGMYCENRCVYCWRPMEFYNSMEMSPDKVASPEEIITNLMEERRKLIM
GHYGDPRQDRKKLDESLLPSHYAISLSGEPTMYPQLPQLIKYLKTFPETKSIFLVTNGQE
PNMIQRLQDEDALPTQLYLSTNAPDEKTFQLVNKPRYKDAWKRWNTSLEMLSKLDTRTVI
RITLIRDYNTSEEFIPKFAQMLKRANVHFIEAKSYMHVGRSTNRLEYSNTLEMPEVRHFA
DEVVKQSKIYSVMDESAISRIVVLQNQNRFIDRWIPAHANAT
>A0A8H4PZW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps sinensis|TrEMBL
MEETHHDFRIDTAPLASLLGYSVFGFGDREGWPNEAEGFCFQAKELDKWMSKLTGRKRAY
PVGMGDMKNGHAQRFAEWAAGIREVVGNVARNATLGEGVRGSGDAVESDEEDAADENDQE
ELEDDPDIEKTTSRALDDVEDLGKMLRTSKDDGNAQNPRAPLAVDFTTYGSSTKTSQAPA
VKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCME
TTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDMIFEGVRENHYKKIKMMRGVPGVRAD
RYAEALKIRHCALSLVGEPIFYPHINEFLALLHAERISSFLVCNAQHPDQLAALKAVTQL
YVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAE
GYAQLVERGLPCFVEVKGVTYCGTSTSSNAGLSMSNVPFYWEVCEFVKALEKRLRAMGLA
YGIAAEHAHSCCILLASERFKVDGRWRTHIDYKRFFELLEERGPDGEWTPEDYMGAPTPE
WALWGNGGFDPRDQRVDRKGRAIENTVIREQPPAEVW
>A0A812K2Y1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Symbiodinium sp. KB8|TrEMBL
MLSRCFQPPKQHTGPGEQAPARPAAHVAGSMEGVTSGQVLLAVVVVIVSAWLLQGLLGAS
KAGDSENATEAGQSEVPETPDETQAETAGEDDKRKHALPVRVLYASELGTAKGFAEELTR
DLFGLNIAGFAVDVSCVSLHEYDQDNLELETVVLFLLPTYEGGVPPANGRVFCEWLADMV
LDFRVSRTWLKNTTFAVFGLGNSDYDENHCEAARQLHRGLCKVGAMPLASLAKGDDSVDM
IAQFRKWRDRIIPKLCEMAAARAPAAAGAAEESPAAAAGSCGSGDCGSGGTDGAPTSLKQ
VKSWEEQEAALRPAASAGQAAAAAKQLARDRSKLTRNQRRRLTREATRNKKMREWQEEQH
ARYAAISEEVHSAWESSTAGTSTGDREVLDDDGVPVTSEDIVNDHVLTLDELEARGLAIP
DSDLEGIRDSTQDAAATAGAAGGHGGGGMVDLEDLAAVYAEAKADMVTPKQFKALTKEGY
KIIGTHSAVKLCRWTKHQLRGRGGCYKHSCYGITSYQCMETTPSLACANKCVFCWRHMKN
PTGREWRWKLDEPEMIVEEAIAKHVAMIKMMRGVPGIKMDRWLAAFTVKHCALSLVGEPI
MYPHIGRFVDLLHERGISSFLVTNCQFPEAISTLPPVTQLYVSVDASTKDALKAVDRPLF
KDFWERFLGSLDALRAKRQRTVYRMTLVKRYNMDAVEGYVNLVTRGSPDFIEVKAVTYCG
ESNASDLTIKDVPWHEEVREFCAAMVQRLREQGEDYGLACEHEHSNLVLIAKRKFWNAEE
GRWWTWIDYPKFHELAAKARASDGAFTFGAEDYMAPTPAWAHYDAPEAGFSPNEVRFKRT
KGGGGYRPLHEIEAEAKAKAEAEAEKTAEG
>A0A830F1X6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sebkhae|TrEMBL
MSDADDGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRELLSGFGGNDEVPREVFDQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQMYVSVDA
ADRQTFDSTVQAMEDDAWDSLIDTLDVLAEKDDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMGEYLPDHDVLKEVEDSRVTML
AEDENTWVPKLEKSSEFWEQDPLVEY
>G3IH71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cricetulus griseus|TrEMBL
MTDKERSLYLFDKKFGSVWVIRSQEKSVPGAPDSSFSLQKKQTHVSGVKIFWHRQGEGFA
QCLSFGFSAFKENSRNLPLAGFAVTLAKAVTSLDLPVAIINLKDYDPDDNLIGEITSKNV
CAFLVATYTDGHPTESAEWFCKWLEEAANDFRFGKTYLKGLRYAVFGLGDSAYQSHFNKV
STNVDKWLWMLGAQRVLTRGEGDRNAVQSKHGSIEADFTTWKTKFISRLQTLQSGEKKAC
SGDSPALQEEEPCESSSEEELGTQDYQSLNSLVDVEDLGNIMSPMKKEKREKAQQEEKAG
VNRNPEKSADSEGRAMITPALREALTKQGYLSTLHCVCRHHTNPVGTEWRWKVDQPELIL
KEAIENHQNMIKQFKGVPGLKAERFEEGMEVKHCALSLVGEPIMYPEIRLLKLLHQHGIS
SFLVTNAQFPEEIRNLRPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKTLAAKQ
QRTVYRLTLVKCWNVEELQAYAELVSLGNPDFIEVKVSFPG
>A0A2K5QP29|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cebus imitator|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGFVSLHNKDIFVSGVKIFYGSQTGTAKGFATVLAETVVSLDLPVAIINLKEYDPDD
CLIEEVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSVYASHFNKVGKNVDKWLWMLGARRVVSRGEGDCDVVKSKHGSIEADFRAWKTMFISQL
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSEEQDELHHRDIEEEEPCEGSSEEEF
GGEDQQSINSIVDVEDLGKIMDYMKKEKREKEQQEEKTSLFGNTGRNEDGERRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMMVKHC
ALSLVGEPIMYPEINSFLKLLHQRQISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KVGSEWWTWIDYNRFQELVQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A1M2YH81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeum sp. AZ1|TrEMBL
MPEQLQKRMEKQGYHFVGQHSAVKICEYTANGLRGETLCYKYTFYGIRSWQCIQGTPAIG
CDIGCRFCWRLIPEEEGFKWNELNALSEWDDPEGIVEGMIKEQRRIVSGYKSIADNELKM
RRWNEANEPKHVAISLTGEPTFYPKLAGLLSAFHKKGISTFLVSNGTLPEAIAKLDPLPT
QLYISLQAPDEETYIYVTRPKIKDTWNRFMKSLDMLHTLKTRTVLRMTLIKGLNMKNEEG
YAGLIKRAMPNYVEVKGFSYVGGARNEERGLSLSSMPNHSEIRDFADRLAELTGYKRVSE
HAPSRVVLLARDEESARNRIIDFSKIG
>S7W738|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spraguea lophii (strain 42_110)|TrEMBL
MLKILYATETNRSFSYATNLSVHLTQHNIDHSISCLSEYTIDNLKEESHVVIIVSTFFEG
MPPRNGKQFYDDILDMKNDFRVGRGVFGHLKYSVFGLGSRAYKELFNVVAREMDRALYEL
GGKRIIKTEYGDEYENMDNYFDSWMKKFTKNYVEEIFDGENEEYGNILDDIEDLGAGNNS
KEMATPSLKRALTKQGYKIVGTHSGVKLCRWTKSMLKGRGGCYKNSFYNIESHRCMEMTP
SLACANKCIFCWRHYTNPVGTEWRWEVDNPKLIFGRALEEHRKMVMQMRTAPGVLEHRYK
EGLDVKHCALSLVGEPIMYPYINEFVDMLHSNSISSFLVTNAQFPEQLKSLKTVTQLYLS
IDAPTKEALYKIDRPLHKDYWSRFTECIKILKDRKERTVFRLTLIKNYNNDDIIHYTTLI
NLGQPDFIEIKGVTFCGYTESTPMKMDNVPYHEDVQEFSKKLLKEINNQNENTTNIDINP
EYDIAAEHKHTCSVLIAKTIFKKNNKWHTHIDFNKFHELIKSNEEFSAIDYSIETPEWTL
PGAKEEGFNPVETRHKRNKNKAK
>A0A401S779|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chiloscyllium punctatum|TrEMBL
MQHFLSLVLLCLCRPGCGEQRDDVYIFDTWNSLKTCALSLWHVRHYIYSTIVVAIGVWAT
VEYLSKNHHKQKNEDNSAPNEADEVIQNGHLVQEVKEVTGVKIFFGSQTGTAKRFAATLA
ESVQKLGLPVEVIDLKEYDPDENLVEEVYSKTICAFMISTYTDGKPNESAAWFCKWLEDA
THDFRYGKTYLRGLRYAVFGLGNSLYENHYNTVGKNIDMWLWMLSASRIMTRGEGDCNVV
KSKHGSIEADFDDWRAMFLSRVQALCKEENKECSGSCQKGKCKTNDQKRNKESSQNEEVP
EKMKDHSSEEEELFETTSEEGSGVEDETESSVLDVEDLGNVMNNMKEAKQEREAAKKVKQ
KTSKRAVGKNEGAEPREMITPALKNALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKH
TFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDEADMILKEAIENHQNLI
KQFKGVPGVKVDRFAEGMKVKHCALSLVGEPIMYPKINELVKLLHHNEISTFLVTNAQFP
EEIRKLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLESLKALADKKQRTVYRLTLV
KAWNVDELRSYADLIEIGKPDFIEVKGVTYCGESSASNLTMANVPWHDEVVYFVQQLADL
LIDYEIACEHEHSNCLLIAHKKFKVNGEWWTWIDYDHFHHLVKEYQENNGSKMFCAEDYI
AKTPPWALFGAKQRGFDPVDTRFLRKRKKDISGC
>A0A293N700|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ornithodoros erraticus|TrEMBL
MSLVGTITLLLIAHAASANEADKIIDEGSASKWLSHTFLTLLCGGIVTLLFFMVVKDKFS
KAQARVSEKEAKKGRSVKVFYGTQTGNAQILSDKLFVELDADGYSVEVINLKRIEPEDCL
LKEVKAKGLCLFIISTSVCGSPPEDAQWFYDWLRDTYADFRVQKFFLQGLDFAVYGLGDS
AYAENYNKVAKDIFFWLSKLGGHAVLPLCLNDESIHEGKYGTGRFAEWKENVSSYLREGR
SQTFLEKEVTDKTYETTSEEEEDVLDLEDLAGKGNRETKATPRATRKQMLTPIIRASLTK
QGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIDSHRCMETTPSLACANKCVFCWRH
HTNPVGTEWKWDMDPPAMIVDAALSNHYKMIKAFRGVPGVQQVKLDEAMQVRHCALSLVG
EPIMYPEINALIRLLHERGISTFLVTNAQFPDAIATLEPVTQLYVSVDAPSEEALKKIDR
PLFQDFWKRFQDSLRALSQKGQRTVYRLTLVKAWNMEEVQGYANLVQLGNPDFIEIKGVT
YCGESKGSSLTMQNVPWHEEVVSFVEKFAALIPEYGIASEHEHSNCVLLAHRRFQIRGKW
HTWIDYDRFHELSLMWKQSNGKEGFTSEDYTYPTPAWAVYGARERGFDPKESRVLRKTRK
DIGGC
>M4DH83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Brassica rapa subsp. pekinensis|TrEMBL
MASSSSIHARLALVALLSATTFYCIHKYRRLKRLKTLSLLNPSTRRGKIFFISQTGTSKS
LAQRLHKLLESNGIAFDLVDPASYEPEDLPKETLAIFVASTWDGGKPPKDGEFLVDWLSE
SAEDFRVGSLLLSCCRFGVFGVGSRAYGDEYNAVAKELSRRMVGLGGAEMVPVGEGDVDD
GELDRAFNEWCDGVIRVLKGGSAQAREANEITQNGVVESEDEYIDTTDEEEEEDSNDIVD
LEDIAGKAPSRKNGVVKVTKRGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQ
LRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPKEIVK
GALDLHTKMIKQMKGVPGVTPEKLQEGLTPRHCALSLVGEPIMYPEINALVDELHGKRIS
TFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKALQEKQ
QRTVYRLTLVKGWNTEELEAYFNLFNIGKPDFIEIKGVTYCGSSATSKLTMENVPWHADV
KAFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVASGEPF
TSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQAVVA
>A0A6P3ZTQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ziziphus jujuba|TrEMBL
MPTMSFSSFPTRLTLLALLSATTFYCFYKSRRLKLLSQSLNPNGKTSSSSPRKAKLFFIS
QTGTSKALAVRLFDLLTSNNLAFDLVDPNHYEPEDLPKENLVLIVASTWEDGKAPPTAKF
FANWLSESSDDFRVGSLLLSQCKFAVFGVGSRAYGATFNAVAKDVSKQMRALGAKEILPV
WEGDVDGGDIDEVFDAWSGKVVGFCKGGVVENGGVSTNGVDCESDACSGDETDEEEYSME
SEIVDLEDIAGKGPSRRSATVTKAETNGTLNGKKDMVTPVIRASLEKQGYKIIGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKM
DDPLEIVNSAIEQHTKMIKQMKGVPGVTVERLREGLSPRHCALSLVGEPIMYPEINTLVD
ELHRRRVSTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERLIDS
LKALKEKQQRTVYRLTLVKGWNTEDIEAYSNLFSIGKPDFIEIKGVTYCGSSATSKLTME
NVPWHSDVRDFSEALALRSLGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHD
LVASGRPFDSKDYMAITPSWAVYGAEEGGFDPDQSRYKKERHHRSSK
>A0A3P9J2I8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
MLIEAMAKCLMVVLFYARCAFASDVNAPQTGSSLSENYLALLWHHRLYLYAAAALVVGLW
VSLKVALSRKSGEKDAVLSGAIKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELKALG
FPAEVIDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYG
RTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSI
QADFQAWKGKFLSRLQALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEVELVESS
SDEDESGLTGEKRSVVDLEDLGNLMKNAKKAKGKNGPQQDGEVVKFSKLNGVKKIDDDDD
GERREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALDKHQDMIRQFRGVPGVKPE
RYEEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLEPVTQL
YVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYA
ELIALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAAMLPEYEVACEHEH
SNCLLIAHKKVRAAPRAVSASKVTKMRLGRI
>A0A2U1NCI5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Artemisia annua|TrEMBL
MPTTTVTTHLTLLTILSAATLYCLYKSHSLRKPKHPKIKKPLNPNPNTPLNPKPTKTPKI
FYISETNTSKNLAKHLYKILKTNNLKFDLINPETYEPEDLHSEDLVLIIASTWQDGLSPS
NGVFLSNWLNESVSDFRVGSLLLKGVKFGVFGVGSRSYGEERFNKVGRGFSSGMKALGAV
EILPICEGDVDEGDLDEVFEKWCEDVVRVLKSGIVDLEDIAGKAPTKKDLEKGAGMRNGK
KNGVKEMVTPVIRASLTKQGYKIIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHSYG
LSLPICASISNGVKATNSVCISYRRDQGMQNLEWALRCRKPIMAHNSRMLLRMLTWCMEA
TPSLACANKCVFCWRHHTNPVGKSWQWQMDDPLMIVNSALDQHKKMIKQMKGVPGVTAER
LSEGLSPRHCALSLVGEPIMYPEINTLVDELHQRRISTFLVTNAQFPEKIISLKPITQVG
MPAFHFALLYVSVDAANKDSMKAIDRPLFGDFWERFVDSLKALKDKQQRTVYRLTLVKGW
NTEEVDAYSRLFSIGNPDFVEIKGVTYCGTSATSKLTMENVPWHADVKEFSEALAQKSNG
EYEVACEHVHSCCVLLAKVDKFKVDGQWHTWIDYEKFHDLVASGKPFDSNDYMALTPSWA
VYGANEGGFDPDQARYKKERNHKTKG
>W6ZG33|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bipolaris oryzae ATCC 44560|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLPILLSALVVATIARLIIYSRDRREKLPTSPVPQSPIQ
KQKVELKPEWLPEYTTTLSSPDLNVDNHAEDDTGAVVAATKVKKGPKMVKGRKIPKKSVS
PTLAFDHKTDKIQPLVFFQSLSGTTERFAAQFAKTITEWTTGCDQASSFLEPQTHDISYI
EHDDYFVTPPKTDANVKYFYIILIPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKSDAERRFEEWRIG
VQEALVELAEGRGLGEGVPGSGDPAESDEEDVDDAEDGNGQSSRVDDVEDLGSMVNSSSS
PVPIDFTTYKKSAPKPKSTSAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPEMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINQLLDIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRTRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELNSRGLQYGIGAEHAHSCCVLLADRTRFMKEGRWATRIDFERFFDL
NEGKVQGTRVEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKVEAEKS
EGQEKQEKMAALEF
>A0A133UTQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA259I14|TrEMBL
MVLTKEEKQNLENGGYRLVGEHEHSAVKICRWTKKSLLDKEICYKQKFYEDIHGIKTHRC
LQMTPSLPFCDNKCVFCWRNSEINSPEWRGAVDDPSEILDEAIESQRKLLSGFKGNPKAN
KRKWEEAQNPNLSAISLDGEPTLYPKISDLIEECYRRDITPFLVSNGQNPQVLTEIKEPA
QLYISTVAPDKKTYINVCRPLVSNPWENLIQSLELLPSFDCVKVLRLTLVKDLSLKDPSG
FSKLIKKADPDFVEPKGYVAVGHSRERLGTSFMPTHSEIKKFSKKLAELSGYEIVDEFKP
SRVVLLS
>A0A7J4B1M0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MVISIDKKIEKKLRNAHYGIFNHSAVQICSWTKSSLRNENFCYKQKFYGIDCHRCMEFSP
AAVFCENNCIFCWRPMEFMKKIHMKKTHVDEPKDIYENLLLERKKLLSGFLGNKNVDKKI
FKDAIIPNHFAISLSGEPTLYPKLPELILFLRNLPQTKSIFLVTNAQEPGMLKKLERKNS
LPTQLYISMNAPNEELFKKICAPSQKDAWKRFKKSLEIFSGLKTRRVIRMTMIKGMNMDK
KYMSEYANLIKKANPHFIEIKSYMWIGLSRKRLKEENMPTHEEIKEFAKEFAKMIDFDIV
DEKEDSRIVLLQNKKERIDRLIKSPIPGSSNLIL
>A0A0M0BR55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|miscellaneous Crenarchaeota group-15 archaeon DG-45|TrEMBL
MWGRAMDIPKELRRVYRRQGYRIVGGHSAAKTCHWVRRSLSTGGAERCYKERFYAIPCHR
CLQMTPSLGRCLQSCVFCWRATPGDLGVDWDQTRFPEDEADGPDEVVEGCLEAHRRALSG
FGGNPEVSEEMLGEALRPVHAAISLEGEPTLYPRLGELVEAFFGRGFRSVFIVTNGLRPD
ALAGLGREPSQLYVSVCAPDEETYRRTCRPLVRDGWSRLMETLELLGSFRCPTVLRHTLM
PRLNMADPAGYAGLAERADATYLEAKAAMSVGFARQRFGYREMAWHSEVRAFAEALSAES
GYGIVDEHPPSSVVLLSRLEKPRRLY
>A0A8C5G3I3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gouania willdenowi|TrEMBL
MLFVDLCCHFVYFSLLFCVFFFLYISVVILCVIWVILGFCHCFVCFFYLSFWVNFVYFSL
IWCVFQFFVVNVCFLFSGSKDVYSGSEKYLLWVWHNRLYLYTAAALCFGLWFSLKMVLKK
VRKSVPSDLVLWVQKSAEKNDRAEVHVSGVKIFYGSQTGTAKGFAAELSEEVKTLGIPSE
VIDMKDYDPDDQLADECTSRTVCVFIVATYTDGRPTENAQWFCKWLEEASTDFRYGKTYL
KGLRYAVLGLGNSAYVGHYNTVGKNVDKWLWMLSGVRIMTRGEGDCNVVKSRNGSVQDDF
LAWKAHFLRRLQALARGDSGSRSSKSSCMKTDGADHEGEEPTLTNHSSEELMETSSDEEQ
SDERTSGSVVDVEDLGNLMDSVKKSKVPETHVSADGQMVKLAKVKKIKDKEGASREMITP
TLRNALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWLWKMDPAEKILEEAMEKHQNMIRQFKGVPGVLPERYQEGLAIK
HCALSLVGEPIMYPEINTFLRLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTK
DSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPD
FIEVKGVTYCGESSASTLTMANVPWHQEVVAFVRQLADMLPQYEIACEHEHSNCLLIAHT
KFKVDGEWRTWIDYERFQELVEAHEASGGTRSFSALDYMSQTPHWALFGAQEQGFDPADT
RFQRRNKTKDVSGC
>A0A366QZP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gibberella moniliformis|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKAEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNVKSQGPRRIKGGIARKPSKNKEEEKDSTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSSRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRVDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKGARDLDDVEDLGRMIKKDDG
STTQKAPLAVDFTTYGSSTKKTVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>Q0CMS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus terreus (strain NIH 2624 / FGSC A1156)|TrEMBL
MAEVSSEGGLVSFWHSYRVPLLVLFLTGFIVVRAYRNLSSKSKTPTASSIPPSPRSQSPV
NNEKPTEKTSPAAASEKSDITPARSPSPKSTGPKRVTGKKPLKVAGRRATSDETPLSFIQ
PIIFFASLTGSTERYAKILLEELQSAARDRADPDNRERGLLPPQIHDLSYVDFDDFFTAA
PKPPSTSPGTRYVYCMLIPSYNIDTVLNTFLGHLDETHHDFRIDTAPLSSLAGYAVFGFG
DKEGWPTEEEGFCSQAKELDRWMAKLTDRKRAYPLGFGDVKSDAESALKEWSHGLQDILG
DIVEHGGLGEGAPGSGDPLESDEEDVDDEGQTSRRRTKAQTVVDLEDIKMGPDGQNTGGS
PIPVDFTTAGKSAAPASQGTEKEMVPTTSPTYAALTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFNGV
KEGHYKKIKQLKGVPGVRAERFAEAMRIKHCALSLVGEPIFYPHINRFLDMLHSEHISSF
LVCNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHV
QRTVFRLTLVKGFNLDDEVVGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFY
EEIQTFVLALNEELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFELLE
KEKADGTSFTPEDYMKETEEWALWGNGGFDPKDERVYSKGKKKKMALAGAGAE
>A0A7L4NVT7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriaceae archaeon|TrEMBL
MPLTIHDFRDLEKKGYRFVGSKNHAAAKICHWTKKSIVGEGVCYKEKFYGIESHRCLQMS
PSISFCHHKCLFCWRDISITETEWNEEYDEPADIIDGCIEAQRNLLCGFFGNPQSDPKKL
AECKEPNNAAISLAGEPMLYPLIDDLLAEFKRRDFTTFLVSNGLSPSRLENLEVEPTQLY
ISLDAPTQEIYRGLCHPQVENGWEKLNESLDMLSSFNSRTVIRMTCVKDYNMSHPEEYAR
LIERSNPDFVEIKAYMYVGNSRKRLEFSNMPRNQDIYNFASSIAELCGREIVNESRESRV
VLLE
>A0A0V1M9T7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella papuae|TrEMBL
MFERTLHAFCPSDMITFNLCESVLIIVGISTALIVLLLYIIMKKKEKHREDVKIFFASQS
GNAQKLAYSLHSRLKSTFSTAVFDLQHYDPEGHLENEQAVCIFIVSTYVDGQCPEKCRWF
FKWLEECVSDFRVEKSVLSNLRFAVFGLGDKAYRNTFNKVAIKLSKHLLLLKANNILPLY
LTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSLHDNKRVSVWRDENENSSDAEDAENN
ANNVDFTNVTNDSDKIKEMLTPTLKKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYK
HTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPADKILFDSLEGHKKM
VRQFRGVPGVKDARFEESATVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQF
PSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILRDKKQRTVYRLTL
VNQYNMNEVSQYAALIKRGQPDFVEVKGVTYCGDSKNSKITMANVPWHADVVDFVQQLVF
QLDDYDIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMA
KTPDWALFGASQRGFDPEDQRWYRKSKVS
>A0A3G1A5Q0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermofilum adornatus 1505|TrEMBL
MESTQRMEVARYLRAGYKLVGNHSAVAICRWTRSAIRGERLCYKSWYGIQSHRCLQMTPV
LNFCDFACKFCWRMHLPGRFKIPNGWRWDEPEDIINGSIIAQRLLLIGFKGNPKVTKERF
LEAMFPRHFTISLDGEPLLYPKLPDLIKRINERNFTTFLVTNGSIPMRLKEMLKKDAHPT
NLYLSLYGPNKEVFQATADPKIPNAWENVLTSLELLDQFKKSRTVIRLTMVRDLNMVEPE
GYASLIKKANPMFVELKGYTWVGESQKRLPITAMPTLDELEKFAEKIQEITGYKIKVKDD
KSRVVMLVRDEEAWETNLKMVEEWKQKVSRLDENWKSKVEDFTMEEHGYKLLYY
>D3TCK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aciduliprofundum boonei (strain DSM 19572 / T469)|TrEMBL
MDPEIERILRKQGYAIVGKHSAVKLCHWLRESLIHERPCYKQTFYGIKSHRCLQMSPAVN
NCTHNCLFCWRFQGFSEVYMKEVDEPEFIVEESIRQQRRLITGYKGDPRVSLEKWKEAME
PRHVAISLTGEPTLYPRLGELIEEYHKRGFTTFLVTNGTMPEILENLDPLPTQLYVTLAA
PNEEIYKKLMVPLIKNGWDRLKRTLELLPSLDTRKVIRHTLVKGWNMKNVEEYAKLDTLA
EPHFIEPKAYVFVGYSRERLTIENMPSAEEVENFARKLSELTEYKYEDERKDSRVVLLMK
ENVQRFIE
>R9SJB6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter sp. AbM4|TrEMBL
MSLSKEEQKILEHSGYRFVGQHGHAACKICHWTRESIVNRGVCYKQKFYGIESHRCLQMS
PAVPFCQQKCSFCWRDLSLTETEWSGSWDDPETIIDEAIKAHNLLLCGYYGNDKADKKKL
EELKQPTNAAISLAGEPTLYPEIDELIGEFNHRGFSTFLVSNGQYYKKLENLRNEPTQTY
LSLDAPNSKIYRSLCNPQINDGWDNLNKSLNILNGFSNNTAIRITMVKGRNMTSPEDYAK
LIEIADPTYVEVKAYMCVGSSRERLTLDNMPTYNEVKDFASKIGSYCGRKVTDGSEISRV
VLLTKE
>A0A3S3SRG1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanosuratincola subterraneus|TrEMBL
MSEGFKRAAGALEEQYKVLRSQGYHIVGRHSAVKTCHWTREAITGGEFCYKGKFYGIESH
RCLQMTPAVSRCSNMCLYCWRVLPHEHGYPSVDDGAEDPPEAIVDGAIAAQRRALSGYKG
NPKTDPDRFREAMDPKHAAISLSGEPTEYSMLDGLIQEFKRKGMTTFLVTNGTNPKRLGE
IPEPTQLYVSLSAPSEEIYRSVCRPASGASWLRLMESLSLLRSFSCPTVIRMTAVKGLNM
IDPDGYSKLISGASPTYVEVKAYMHVGFSVTRLGYDSMPSHAEIVQFARDLAERTGYELA
GEVPISRVALLSRIGKPKKVSTPI
>A0A2I1DHL6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus campestris IBT 28561|TrEMBL
MAQGSLVEGLLTLWHAYRVPILVILFTALLVSRTIGITGSKSKAASAFSNPTSPRSHSPE
KSEKAQLDDARDRPAPTPADPPKTAAAGPKRVSGKKPAKVAGRRAGAEPAPQMSAIQPIV
FFASLTGTTEQYAKVLMEELTTAAKDQADAENPERGILPPQLQDISYLDFDDFFTTAPKP
PPNSPGTRYLYCLLIPTYNIDTVLTTFLGHLDETHNDFRIDTGSLSTLAGYTVFGFGDKE
GWPTEDEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDGEAALKEWSRGLQDIMRDIL
DYGGLGEGVPGSGDALESDEEDVDDEESGKTNKNGRKRGKPQAVVDLEDIKMGAGDSGAA
APIPVDFTTGGQSAPPTQSTEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFDGV
KDGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINGFLDLLHAEHISSF
LVCNAQHPDQLETLHRVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILREKRHV
QRTVFRLTLVKGFNVDDEVNGYADLVEKALPCFVEVKGVTYCGTSSSAGAGLTMKNVPFY
EEIAEFVVALNKELERRGLDYGIAAEHAHSCCVLLASERFHVDGKWHSRIDYQRFFELLE
KEKADGTSFRPEDYMRETEEWAMWGNGGFDPNDERFYRKGKKKALEAAATEVATEAATEF
>A0A1J7JQR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coniochaeta ligniaria NRRL 30616|TrEMBL
MALEITNWNPLTGPLVQDVIQLWHSYRIPILLVTFTTLMLLRAYLHTTTDKQDLLLFPTL
YNAPEEKKTSIQAPKNDAPAAQTVAKPKEPRRIKGELGRKSSPDRNGSGLREIQVYIFFS
SLTGNTEKIAREYGGRLEQSLKAIVPRDGETFAFLAPQVFDLAEADYDEYFISPPTVQTQ
NIGTPAEVFYLFLLPSYNIDTINDNLLEHLKETHHDFRIDTAPLSGLLGYSVFGFGSREG
WPTEEEGFCCQATEVDKWMAKLTGRKRAFPLGMGDLKEDGMKRLGEWDEGVVDVIGLLAR
TGSLGEGVAGSGAPSESDDEAEAEDDDGEVVFDDELPTKTAKSKKGGDLGDVEDLGRIMQ
DSRPDGVDVKVPIAVDFTTYGKDGKGRAKTTTVTVKEMVPKNSPTYNSLTKQGYQIVGSH
SGVKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTSW
RWVVDPPDLIFSGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHIN
EFLRMLHAERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNRESLRKIDRPLHRDFWER
FQRCLDILRERRFRQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEIKGVTYCGTST
SSSAGLTMGNVPFYHEVCDFVTALNAALERRGLRYGIAAEHAHSCCILIASERFRVDGKW
HTLIDYEKFFELLEEKGPDGDFSPEDYMGAATPEWATWGNGGFDPRDQRVDRKGRAIEI
>H2R594|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pan troglodytes|TrEMBL
MKLSVCVILNLDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKMQEKSVP
KAAQDLMTNGYVSLREKDIFVSGVKIFYDSQTGTAKGFATVLAEAVTSLDLPVAIINLKE
YDPDDHLIEEVTSKNVCVFLVVTYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRDA
VFGLGNSAYASHFHKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEANFRAWKTK
FISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDTKEEEPFESS
SEEEFGGEDRQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAM
ITPALREALTKQGYQLIGSHSGVKLCRFFFFFIQYSMLRGRGACYKHTFYGIESHHCMET
TPSLACANKCVFCWRHHNNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAER
FEEGMMVKHCALSLVGEPIMYPEINRFLKNLEPVTQLYVSVDASTKDSLKKIDRPLFKDF
WQRFLDSLKALAVKQQQTVYRPTLVKAWNMDELQAYVQLVSLGNPDFIGVKGVTYCGESS
ASSLTMAHVPWHEEVVQFVRELVDLIPDYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDY
NCFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKNKSKAISGC
>M7BYX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chelonia mydas|TrEMBL
MSLWLNRFYIYSCAAFGIGIWICFQFITTKAKKQDEKSTQKLTPSKVTKDVLINGYTMPK
TKEVYVAGVKVFYGSQTGTAKGFATILAEAILSLNLPAEIINMRNYDPDDCLAEEAISKN
ICVFLVATYTDGQPTENAAWFCKWLEEAVNDFRFGKTYLRGMRYAVFGLGNSLYVDHYNT
VGKNIDKWLWMLSASRVMTRAEGDCNVAKSKHGSIEADFDAWKARFLARLQALCKGEKKP
CSGNCKKGKCKSKGKQSKEGSDHEQRVSEQENTEVEDLFETTSEEESGAEEDGSRNSVID
VEDLGKIMGHMKKAKKERELGEEAGRTGPSQQSSGKNEESERREMITPGLRDALTKQVNS
TTSSVDAVILVQRYLILVYSVRHLPNYIKLFPGHHTNPVGTEWRWKMDQPEMILREAIEN
HQSLIKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVT
NAQFPVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKVPN
>A0A7K4UI58|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sinosuthora webbiana|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKVRIENLLVQVG
KDKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVINMGDYDP
EDGLVEETSSRSICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFG
LGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVTQSKHGSIEADFEAWKTKFLT
RLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSDHEHGASEHENTETEELFETSSEEEAG
GTDSVIDVEDLGNLMGHMKKAKVLLLGGWNLPFHTSAKADPELQLLKMPSACRFLEFFCY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWRWKMDQPEVILQEALEKHQNMIKQFKGVSGVKAARLEEALAVKHCALSLVGEPI
MYPHINRFVRLLHQHGISTFLVTNAQFVKAAIPFSICRRLEPVTQLYVSVDASTKESLRR
IDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDEVKAYADLISLGKPDFIEVK
GVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIACEHEHSNCLLMAHSKFQVD
GEWRTWIDYGRFQELVGEYEQSGGSRTFTAAEYTARTPPWALFGARERGFDPSDVRFQRK
NKARDISGC
>A0A446TGG3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum turgidum subsp. durum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSIALRRLRRTLRPSPSPSSSSPAAAAXX
XXXXATGTSKALAERLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGAPPP
GAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALGAVE
VLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEDDAVDGETNGFDGLEGEESDYDDDD
DEEEEEEVASGEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEKQGY
KIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPI
MYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDRPLF
SDFWERFLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVTYCG
SSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKINGKWH
TWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAALKG
>A0A818TFZ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTIDLYIFAASSALTGLVFYYLAGAEWSLWHLFAIPLYTFVFVVFLSLSIIKRFKSLSKP
LQSLTKIIRQEKNGITIVFGSVTGNCRTFAQLTYDKLSKELNYQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDDTPPPSAKWFVNHLQDAATDFRVSKNELEKLTYAIFRCGNS
FYNDNFNTVAKELDRCLSELGAKKLIPTELADENSGKSIYGGREGHYSKWSSQLKSAFQS
PKTDKCDCSNENSIKCCQSLTNNDHPIEKKENDEQLRIESDDDDEDGGCKNGNDDIMDLE
DMGDYMATHSPTKTTKGPPKEMITPVIRKSLEKQCYKLIGTHSGVELCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVDGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A815IS99|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rotaria sordida|TrEMBL
MTVDLYILAAGSALTGLVFYFFAGAEWSLWHLFTIPLYTFVFIVFLSLSIIKRFKSSSKP
SESLTKIIPQEKNGITIVFGSVKGNCRTFAQSTYDKLSNELNCQVILQDLNDITDPEEFL
QIQAKNQRKLLIFISTYEDGTPPPSATWFVRHLQEAATDFRVSKNELEKLTYAIFGCGNS
FYDDNFNKVATELDRCLSELGAKQFIPTELADENSGKSIYGGLEGHYSKWSSQLKSAFQS
PKTEKCDCSNENSINCCQSSTNNDHSIEKKQNGEQSRIESDDDDEGGGCKDGDDDIMDLE
DMGDYMETHSPNKTAKGPPKEMITPIIRKSLEKQGYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTSWQWKTDDAQTVCQGAIENH
YKMINTFKGVPGVLPQRLAEGMQIRHCALSLVGEPIMYPHINELIGLLHSKKISSFLVTN
AQFPDEIKSLEPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLNSLRALKDKGQRTVYR
LTLVKGYNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASNLTMANVPWHEEVVTFVKL
LCDRLPQYGVACEHEHSNCLLLAHNKFHVGGKWHTWIDYERFHELVARHKATSGGETFTS
LDYMAMTPDWGVVGSNERGFDPNDIRWYRKATAKKNISGC
>A0A4W6CWS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lates calcarifer|TrEMBL
MLNFFLILLLFIIHVSASDSKGDYFMSIWHNRLYLYSAAALVFGSWFAVKMALKKVNLVC
FPLDKNNNCSDKDTVVHVSGVKIFYGSQTGTAKGFAVELSEEVKTLGIPAEVTDMKDYDP
DDQLADECTSKSICVFIVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFG
LGNSVYVGHFNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWKVKFLN
RLQALAKGEKKSCSGNCKTGGTCKNKRKDRQVMEEEKAEELIESSSDEDESGLQDEKKSG
SVVDMEDLGNIMNSAKKAMSKEEGRGDGQMVKLSKLNGVKKIEDEGERREMITPALREAL
TKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCW
RHHTNPVGTEWRWKMDPAEKILQDAVEKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSL
VGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQEIRSLEPVTQLYVSVDASTKDSLKKI
DRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKG
VTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVEG
EWWTWIDYERFQELVQAHEESGGQQSFSALDYIAKTPSWALFGASEQGFDPADTRFQRRN
KTKDISGC
>W9ZI98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Capronia coronata CBS 617.96|TrEMBL
MDLGEGGATPVILADWLDRLLTSWHDHRVVVSALVLLCLFLVWVRRHKQVRRVTSHPSSP
GLEKADWPGQTADQPSNNVKTASKEAQLAKTDQTRKTRPTAARVVTGRKPTGTKAERSLQ
RQAEPSQIQPMIFFSSLTGTTEQLTKQVAAELEIFSNSQSSILKPQLYDLSYIDLDDYFI
SGPKTPVPRPNVHYFYLLLIPSYDIDTIINTVLAHLDETHNDFRIDTAPLSTLAGYTVFG
IGDKEGWPSEEKGFCSQAIEADKWMAKLTGRKRAYPIGLADVKGNLTGALKDWIAGVCSV
FEELSITGTLGEGVPGSGDAIESADEEEADEGEEEDMEFPDSGRNKRRKLAATTDLEDVG
GKNGSPLAVDFTTYSSSAPVALKAMVPKESPTHAALTKQGYTIVGTHSGVKICRWTKSAL
RGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPQAIFDG
AKEGHYKKIKMMRGVPGVRSDRFAEAMRIRHCALSLVGEPIFYPRINEFVGLLHSEQISS
FLVCNAQHPQQLRDLDRVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQSCLAILREKRF
VQRTVFRLTLVKGFNVDDEVEGYADLVAKGLPCFIEVKGVTFCGTNVSSSAGLTMGNVPF
YHEVVTFVEALDKALVKRGLDYGIAAEHAHSCCVLLASKRFLINDKWHTVIDYDKFFGLL
KQGVEFAPEDYCKPTPEWALWGNGGFDPRDVRVDRKGRPKELNDTVQRGLAAAVEDF
>A0A133UBA5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|candidate division MSBL1 archaeon SCGC-AAA259A05|TrEMBL
MKLSRKALRRLEKGGYRLVGKNKHSAVKICRWTKKSLLEEGICYKQKFYEDIHGIKSHRC
LQMTPSLPFCDNKCVFCWRDVNLNSPYWEGPADDPSEILDEAIEAQRSLLSGFKGNPEAN
KEKWDEAQNPGLAAISLDGEPTLYPKLDGLIEECYRRDIVPFLVTNGLHPDRLEEIREPA
QLYISTVAPDGKTYKKICRPLVSRAWEKLNQSLEVMQSFDCTKVLRLTMVKGWNMKDPSG
YGELIKKVEPDFVEPKGYMFVGHSRKRLKMENMPTHEEIKNFGRALERETGYTITDESEP
SRVVLLSAEN
>A0A8H7SF09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mucor circinatus|TrEMBL
MLAIDPDASNDGSCACTGSVGGTCCKEQPQEQQEQEIVKNEIESLKIIYSSLTGTAKTFG
EELKRQLLAAEKNITIKELELVDITEYDNDDLLTETSVCVFLLSTYNVEGPLDWFTKWLR
DIRYDWRVDRLALQKLRYAVCGLGDSAYGDEFNVASQQIDKWLGQLGATRIYPLGSCDKN
ADQKAQFDEWARQFINELHDKQSLEFSPAKIEYGSDGEEEDEEDTEESSNNKEIDVDGSG
DEMLDVEDMGKMAGKLKAAKANRAREEQEFETAQAKAKRSIGTDEGVVKKANQPRAMVSP
MLHKNLTKQGYKIVGTHSGVKICRWTKSALRGRGFCYKHSFYGIQSHLCMETTPSLACAN
KCVFCWRHHTNPVGTKWRWQVDDPKFILDGAMENHYKMIKQLKGVPGVKADRFQEAFTIR
HCALSLVGEPIFYPHINEFVKLLHEHNISSFLVTNAQFPDKIAEMELVTQLYVSIDAGTR
EGLKKIDRPLFRDFWERFLDSLEALADKGQRTVYRLTLVKDHNTEELDNYVELVRRGRPS
FIEVKGVTYCGYSGASNLTMANVPYHHEVVDFCQKLCDKLGNGYELAAEHAHSCSILIAK
SDFKINGEWHTHIDYNKFFELIKSGEPFTDMDYVAKTPDWAVYGAEAGGFDPEETRFYRK
NRKAEAAAEAAKTAATVAAEKAAAIASA
>A0A075HQI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured marine thaumarchaeote KM3_81_E07|TrEMBL
MSCSGEVVEKEPELIQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFY
GISTHSCMEFSPAGMYCENRCVYCWRPMEFYDSMEMQPQNVAEPEEIMTKLMAERKKLIM
GHYGDPNQDKKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIRKLEDGNALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLNMLSTLSTRTVL
RITLIRGYNDDEEMIPAFASLLQKSNVHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRSFA
DKLVQENNVFTVMDESEISRIVILQNKKRFIDRFIPAYC
>A0A368AXM1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGEVVENEQENLIQIKPAIAAQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHQF
YGILTHRCMEFSPAGMYCENRCVYCWRPMEFYDAMKMEPEQVAEPEQILRKLMGERKKLI
DGFYGDSRNDKQRLDESLLPTHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQ
EPDMIQKLQDEDALPTQLYLSTNAADYESFIKINKPKYDDSWERWNRTLDMLKDLDTRTV
LRITLIRNYNDQKEMIPAFADMFRKASPHFIEIKSYMHIGRSTNRLEHENMLEMSEVKKF
SEEIAKQSKIFSIMDESLVSRISILQNNERFIDRYISAYANTN
>A0A6A6QJI7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lophium mytilinum|TrEMBL
MDFSTRLGQLPTEIFEIWHAHRLPVILSAISLIAAIRLIQNARRKRERLSLSPAPASPAE
KDEDISLPWQLEGRTEKQTLLPEIRAEDSSPPLVQLRNRGPKTVKGVKLKSGQKQAKDFD
HTTDKIQPLIFFSSLAATTEVFATKFAEELATWIEATSDIQSLLRPELLDLSYIEYDDYF
ISPPKTDPNTKYVYLVLLPSYDIDTVLDIFLENLQETHNDFRIDTAPLSGLLGYSVFGFG
DKEGWPTEEEGFCSQAKQVDKWLAKLTGRKRAFPLGMGDVKGAAQERLNEWRMGVQEVVI
EIAAGRGLGDGVAGSGNPVESDEEDMEDVDNSDEESTKARKPQKTARVDDLEDLGRMINT
EEAAESAPLAIDFTTYKSKRKTPAVVQLKEMVPTSSPTHASLTKQGYSIIGSHSGVKICR
WTKSALRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAP
EVIFDGITTAHYKKIKAMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELVAIMH
ANRISTFLVCNAQHPAQLEALIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDI
LKRRRLEQRTVFRLTLVKNFNMADEVRGYADLVERALPGFVEVKGVTYCGTSAAGGAGIT
MENVPFYEEVAAFVEALAKELSSRGLHYGIAAEHAHSCCVLLADEERFLRNGKWATRIDF
EKFFELYEGGGEWRPEDYIGGETPEWALWGNGGFDPRDTRVWTKGKNKGRVIVGGGGVGS
EKAKKQGVETLWNQES
>A0A842P1L5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilus sp|TrEMBL
MSCSGETVEEEELLQIRPLITAQLKKAKYGVADHSTVGLCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMYCENRCVYCWRPMEFYDSMQMKPEQVAEPEQILTKLMAERKKLING
FYGDSRNDKQRLDESLLPAHYAISLSGEPTMYPKLPELIKYLKTFEATKSIFLVTNGQEP
DMIQKLQDEDALPTQLYLSTNASDYESFMKINKPRYDDSWERWNRTLDMLKDLKTRTVLR
ITLIRDHNDQKESIPAFAEMFRKASPHFIEIKSYMHIGRSTNRLEYANMLEMEEVKSFSE
EIAKQSKIFSIMDESIVSRISILQNNERFIDRFIPTYANTI
>A0A841H9S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacterium salinarum|TrEMBL
MSESDGPKQVDDPDYHHENHTAAQTCGWTANAMRGEGTCYKHAFYGIRSHRCIQMTPVVR
CNERCVFCWRDHSGHTYELDGVAWDDPEAVVDASIRLQRKLLSGFGGNDEVPRERFEEAM
EPRHVAISLDGEPTLYPHLPELIEAFHDRGLTTFLVSNGTRPAVLRECDPTQLYVSVDAP
ERATFDDVVGATEDDAWERLVDTMDVLHAKDDTRTVLRTTLVGGQNMANPDWYAGFFERA
APDFVELKAYMHVGDSRDRLGRAAMPDHEDVLAFARAVKTHLPHSVLREQPASRVALLAR
DEDTWVEDLQPESAFWTEGARPTAD
>A0A8H7BM32|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Apophysomyces ossiformis|TrEMBL
MSDIVNSLLYGFSSILSIGPEKPRENEKSGCACSGSAEPNNKEGGCCRSQPTPPKSNGCC
QSQSQAPAQKKTGCCKSQPKQEEETAAAATENHPAGCCGGHNNDSGPTEIASLKILYSTL
TGTTKTLASELQEKLQAASHVSIGQIQVMDITEYDNDDLLTETAVCVFILSSYNVEGPLD
WFTKWLRDLRYDFRVDRDALKKLRYAVCGLGDSAYGDEFNVASQNIDKWLGQLGATRIYP
LGACDKNADQKGQFDEWVHQFICELEDKRSLEFAPANIEYDSEGEDGDEDSEEAAGINEA
IGAGSGDEMVDLEDMGRMMSKMKAAKKDRAEEEAAALANSSKGRAKRVIGDEPKKVEARD
MVSPMLHKNLTKQGYKIVGTHSGVKICRWTKSALRGRGFCYKHAFYGIQSHLCMETTPSL
ACANKCVFCWRHHTNPVGTVWRWKVDDPKFILDGAMENHYKMIKQLKGVPGVKADRFQEA
ATIRHCALSLVGEPIFYPHINEFVTLLHERNISSFLVTNAQFPDKIAEMVPVTQLYVSVD
AGTKEGLKKIDRPLFRDYWERFLGSLESLSHKGQRTVYRLTLVKDHNTEEIDNYVNLIRR
GKPSFIEVKGVTYCGYSGASNLTMANVPYHVEVVDFCKKIIEKLGSGYEIACEHAHSCSI
LIASTDFKVNGEWYTHIDYPKFFELVKSGQPFTSLDYMAKTPAWAIFGTPEAGFDPDETR
FYRKNRKNVEPPVIAAS
>A0A654M077|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosocosmicus oleophilus|TrEMBL
MSCSGEIYSHSNTDADLIQITPAAKQKLKKAKYGVFNHSAVELCHWTKKSFSDGGSCYKH
KFYGISTHRCMEMTPTALNCENRCIYCWRPTEFYDTMEMPAHLVDDPEIIVQNLLEERRK
LVVGYYGKTGVNFSKLDESLFPEHYAVSLSGEPTMYPKLPELIKYLSRLKATKSIFLVTN
GQEPEMLYRLANENALPTQIYLSTNASNKNLFYKINGPRHRNAWERWLQSLDFISQVNTR
TVLRFTLIRNFNDNPIFLEDFAKLVEIGNPHFIELKSYMHIGMSTNRLEESNMLEMDEVR
AFSSGLKTHLDDYSIMDESIVSRIVVLQNKARFISRWIDSYPQ
>A0A1L0C219|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|[Candida] intermedia|TrEMBL
MDLKSAIFAVCCALYYFSGGRFSLVVAASTWYVLSTRGKESLTRQKPLPIKEVDFTHAYM
PEPTTVFPKQRKTVKRARSPKVFRGAKPAVKDQGTVLTSTPIRLMDSQVYIFYTTLTGTS
QRVAAALHDKLANLEGIAHEPKLLSLDDDVDDLEEYFLKTPKNSTQNIYLLVLPSYETDS
PIDYFIEHLTDTFQDFRVDKYPLRSLAGFAVLGLGDSESWNGSKFCYQALLADKWLGKLG
ARRLFPVGQVCVKHEGEPKTQEWINGFASLLADDEPFYIDDNDAADDSDAEEDELDPATD
VVDVEDMGAIIKASGGSFTVEPKQMVAQDSPTFRSLTKQGYTIVGSHSGVKICRWTKSAM
RGRGSCYKYAFYGIKSHLCMETTPSLACSNKCVFCWRHGTNPVAKLNWRWEVDPPEKVLA
GALEGHYKKIKQMRGVPGIQLDRFQEAFQVRHCALSLVGEPIFYPHINEFVGMLHERHIS
SFLVCNAQHPDHLARLAKVTQLYVSIDAPTKKDLKKVDRPLNADFWERLMSCLDILRTTQ
AHQRTVFRLTLVKGFNMDDIESYADMVERAQPSQIEVKGATFCGSSNANGNPLTMQNIPF
YEECRVFVEKLTAELKSRGLSYELAAEHAHSCCILIAHTKFKINDVWHTHIDYPRFFELL
ESGEEFCDLDYVKETPAWAVWGSTEAGFNPEDTKYDRKAEKAKKREAREALAAKVADL
>A0A7J9PRH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVKKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYLDELIEVFHKKGMSTFLVSNGILTDVIVKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLEMGKILGENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A1G4JRN8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lachancea nothofagi CBS 11611|TrEMBL
MDISKDFTDHLLALAVTATYLLSGGRLTIGCSIIVMYALVKHDSVKKSKLANLESSEQGD
APKKKTCCGGKGGSSCCSSKPGGKKGGCCGGNCSSKKKNPSVEKIETVTPLSLSESADDL
AIDFTQAFKPIKKARKMPKLVSGTKPHTKSTFFKKALTVSNEKLIDSQIYIFYSSLQGAA
ERSAKILLDVLSSLKDLTLAPKLMNLDDLSDFDDYFVNVPNSNALYIMVLPSYDTDSPLD
FFLQSMDENYNDFRIDKHALRKLTGYAVLGVGDSESWPDKFCYQAKQADVLLAKQGGRRV
FPVGEVCMKFGGDPKVMEWAKLLAETLQDDEPILYEYDESLETEEAEEPTDELTKESLID
LEDVGKSSELQDVNEIKQMIAKNSPTYKNLTKQGYTVVGSHSGVKICRWTKNDLRGRGSC
YKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVSKTWRWEMDDPEYILENALKGHY
AKIKQMRGVPGVIAERFAKAFEVRHCALSLVGEPIMYPLISKFVGLLHQKRISSFLVCNA
QHPEPLRDLGKVTQLYVSIDAPTKTELKRVDRPLYRDFWERMMECLEILKTSQSHQRTVF
RMTLVKGFNMGEVNAYADLVQKGLPCFIEVKGATFCGSSDGNGNPLTMQNIPFYEECATF
VKTLSAELQRRGLNYDVAAEHAHSNCILIADTKFKIDGEWCTHIDFEKFFELLESGKSFN
HLDYIAKTPEWALFGNGGFAPGNTRFYKKKKNTDESKQSESEAARVASVSPIIA
>A0A178F7N5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichophyton rubrum|TrEMBL
MAAIPLQIALSLWHAYRAYILVIIVVTFLAVTKFSSQRKQVESQPRGVEQVTQKTTISDK
PAQPGNTTLAKSTPLKSEPKPGPKRLRGLRPLKGVANVTAQAVSAIRPIFFFTSLTGTTE
KSARAAFESVRSKLQAAPQNAQCKVLDPELHDLSYIDFDDYFVTAPKPPTSEPGLSYLYC
IILPSYDIDSIINNFLNHLDETHNDFRIDTSPLSGLTGYSVFGFGDKEGWPTVEEGFCSQ
AVAVDKWLAKLTGKRRAYPLGFGDAKTDGDHSLQEWCDGIVSVLHDISENGGGLGEGVPG
SGDPIESDEEDAEEDSQQPQNLNRPRRTKTRNSQVADLEDIKFNPEVLLDDEPIDFTTYA
STKISSLSSKEMVPSTSPTYTALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYG
IKSHLCMESTPSLSCSNKCIFCWRHGTNPVGTTWRWKVDPPELIFNGVKEGHYKKIKMLR
GVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLSLLHGEHISSFLVCNAQHPDELA
ALQRVTQLYVSIDASNRESLRKIDRPLHRDFWERLQRCLDILREKRNVHRTVYRLTLVKG
FNIDDEVEGYADLVEKGLPCFIEIKGVTYCGTSSSSNAGLTMQNVPFYHEIVAFVVALNE
ELERRGLSYGLSAEHAHSCCVLLASKRFLINGKWHTRINYERFFELLEREKQTGESFTPE
DYMRETEEWALWGNGGFDPNDQRVHTKGKNKGKIGVPPPSGKVILAGTA
>A0A6Q2Y8D0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Esox lucius|TrEMBL
MFLKHLSIFTLPQTIALETKAKMLQGSTLLLLDFITDILCADIDGKKTVRSTLESYILLV
WQNRLYLYTAAAVFVGIWFSMKIALKKKILTTPVNPWLYKSVKQNVYSVENVNVVHVSEV
KIFYGSQTGTAKCSTKSICVFLLATYTDGQPTENAKWFCKWLEEASTDFRYGNNYLKGLR
YAVFGLGNSVYDSHFNTVSKNVDKWLWKLSGVRVLSRGDGDCNVVKSRHGSLHSDFLVWK
TKFLSRLQTMVAGPKACRGKCKTGGSCNNRKKPQKTDDEQAAPEQLSSEEELVESSSEEE
AAGTGPDEQHPGSVIDVEDLGNMMNGMRKAKRRVEGQVDEQMKLPRLNRQKKAEEEEERR
EMITPALRVALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPS
LACANKCVFCWRHHTNPVGTEWRWKMDPPEKILLEAVENHQNMIRQFRGVPGVRLERYQE
GLKVKHCALSLVGEPIMYPEINAFLCLLHSQRISSFLVTNAQFPQEIRNLVPVTQLYVSV
DASTKDSLKKIDRPLFKDFWTRFLDSLKALGEKRQRTVYRLTLVKAWNVDELKSYSELIS
LGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVQQLVDMLPQYQIACEHEHSNCL
LIAHTKFKVDGEWWTWIDYERFQELVQAYEESGGSQTFSAMDYMAKTPMWALFGASERGF
DPTDTRYQRRHKTKDISGC
>F4HJH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus sp. (strain NA2)|TrEMBL
MISIKPGKITVQANPNMPEEVAALFKKQHYEIVGRHSGVKLCHWLKKSLTEGRFCYKQKF
YGIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTELPEPWDDPAFIVEESIKAQRKLLI
GYKGNPKVDKKKFEEAWEPRHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPE
RLEEMIREDKLPTQLYVSITAPDIETYNRVNIPMIPDGWDRIVRFLELMRDLPTRTVVRL
TLVKGENMHSPENYAKLILKAKPMFVEAKAYMFVGYSRNRLTINNMPSHEDIKEFAEALV
RHLPGYHIEDEYEPSRVVLIMRDDIDPQGTGVEGRFIKH
>V9D4I3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cladophialophora carrionii CBS 160.54|TrEMBL
MDMGEDAAPVILADWLDRLLTSWHDHRILLASGLVLSVLAIIVRRRRAARITLRDSSPGL
EKADWLAADEGAARTATNEKNETTSIYVDQLTSGQARKPRPAAARVVTGRKPVSSRGHTS
PQRQTNPSYLQPLVFFSSLTGTTEQLSKKVAAELESLATTQSPILKPEVYDLSYIDLDDY
FITGPKTNKSAQNVRYFYLLLIPSYDIDTILNTFLAHLDETHNDFRIDTAPLASLAGYTV
FGIGDREGWPTEERGFCSQAVEVDRWMAKLTRRKRAYPLGLGDVKSNIEQATKEWTGGVC
DVLQELSVSGTLGDGVPGSGAAVESDQEDEPDAGYDNDDDFPDSGRNKRRKLANTTDVED
VGGKSAPVAIDFTKYSTTSTSAPVPLKAMVPRESPTHAALTKQGYTIVGTHSGVKICRWT
KSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDPKM
IFDGAKEGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLHGE
RISSFLVCNAQHPQQLDDLRRVTQLYVSIDASNRDSLRKIDRPLHRDFWERFNACLDILR
AKRFEQRTVFRLTLVKGFNVEDEVEGYADLVAKGLPCFVEIKGVTYCGTSTSSSAGLTMQ
NVPFYEEVVAFVEALNTALAKRGLEYGIAAEHAHSCCALIASNRFLIDGKWHTIIDYDRF
FALLQGGQDFKPEDYCKETPEWALWGNGGFDPRDERVDRKGKPKEATKADEVARGRKTKT
GTVVAVQSGGLDF
>A0A8F5ZFU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanospirillum hungatei|TrEMBL
MHSGQCEPPEKALRGMGYQFFHPDSSAALKPCLWCKRSLTGGDQCYKNQFYGITSHRCVQ
MTPTLRCNHKCLFCWRSFEHEYTGEKDLDPKEIVARIPFLQKKALGGYKVSPRVTKEKWE
EALQPDQYAISLSGEPTLYPHLPELIDLLNQTGGTTFLVSNGTMPNVLKQCHPYQKYISL
TGPDRETYLRIARPDEDYWDRILESLSDLGHETDTGHRTAIRVTLVRGINDQNPEGYARI
IQESGAQFVEVKAYMHVGYSQRRLTIKHMPLHDEVERFTQRMLPHLSYKIRGENSLSRVI
CLERDS
>A0A1U7LTY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neolecta irregularis (strain DAH-3)|TrEMBL
MLGVLVAAVWGDLRFAVLYFILLFTAITCGADFTREIPANIFEKKIKRKIKGSLVVGQKK
KIPQKPVKLTENSVLHIFYSSLNGSTERFAQSIVPILPYGHHLHNIDYLPGLDEYFSNPA
KDSTYLLIVPSYNTQSPLDYLLSTLRDIYHDFRVGKNPLLKVNFAVFGIGDGDYAHEFCY
QAKEADKLMGKLGARRLLKVQCGDIRVDAQGSIEKWATVLHDLLLESPDLTPDDSPSDSE
EDAPPSNSIADLEDMGAIMKISRAPGVKEMVSKDSPTYNALTKQGYKIVGTHSGVKICRW
TKSALRGRGSCYKFSFYGIRSHNCMETTPSLACANKCVFCWRHGTNPVGTSWRWKIDPPA
VILEGAIKGHLEKIKTMKGVPGLRLDRFEEAQTIKHCALSLVGEPIFYPHINEFVSMLHE
RHISSFLVTNAQHPDAMARMGQVTQLYVSIDASTKESLKAVDRPLFKDFWERFLKCLDIL
STKRQRTIYRLTLVKGYNVREIGEYAELVKRGKPCFIEIKGVTYCGNSDQSNLTMSNVPY
FDEVVTFTEKLVSYLGPSYGIAAEHEHSNCILVARKEFSVDGVWHTWINYDRFFELIESG
EEFGPEDYMSPTPAWAVFGMGGFNPEDERWRRKKKEDAKSEKINHAT
>C9S7T0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Verticillium alfalfae (strain VaMs.102 / ATCC MYA-4576 / FGSC 10136)|TrEMBL
MSGSRDSWALMPLLNDLHDAWQQVRIPVLLVVALGLVGLRIYLQVTGERPEQPKALPKKL
AADKTVAEKAALARDAKTEKLPLVTEASAAPKAPKTATGPRRVKGGVVRRRSSDDSVDKA
AARPPRRIQPLIFFSSITATTPKIAKQFAEDLGRDMHRAAPETSCTFEAPELLDLAEVDF
DDYFITPPKAKGDVELLYLFLLPSFNIDTINDTFLEHLKEIHHDFRIDTAPLAPLLGYSV
FGFGDREGWPNEQEGFCFQAKELDKWMARLTGRKRAAPVGMGDPKTDYAERLAEWSEGIV
EILGQLARTGGLGEGMPGSGAPVESDEEDVDEEDDDETLVEDGEAKPEKLKNSKNLEDVE
DLGRIMRDSRPDAAPSTGKGAPIAVDFTTYGKTAAKKAPAPTVKEMVPKNSPTYASLTKQ
GYTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHG
TNPVGTTWRWVVDPPEDIFNGVKAGHYQKIKVLRGMAGVRADRSSPCCTPSASRPFLVCN
AQHPGQLASLRAVTQLYVSIDAADKESLRRIDRPLHRDFWERFMRCLDILRERRLKQRTV
YRLTLVKGFNVDEEVDGYAALVERGLPCFIEVKGVTYCGTSTASNAGLSMSNVPWYWEVC
DFVKKLEARLGEKGLQYGIAAEHAHSCCILLASDRFRVDGKWHTTIDYQRFFELLEERGP
DGEWRAEDYMGPATPEWATWGNGGFDPRDDRVDRKGRKIEAK
>A0A8H3W8T1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum asianum|TrEMBL
MASPLDRPGILPVLNNFHDVWQEIRIPVILFTAFGLLVLRFYLHSVEEKDELKAFPKALN
REKPESKPLPKPVDEKKDAKPTPVVEAKAPKSNGPKRIKGGLVKRPSEELKNGEALTRTV
RPLIFFSSITANTPKIAKDYAERLEKELEKVTADTGCSFNTPEVLDLAEIDFDDYFITPP
KSEDPVELFYMFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSPLLGYSVFGFGDREG
WPTEDEGFCFQAKEVDKWMAKLTGRKRAFPVGMGDTKRDYVERLSEWSEGVVDVLGMIAK
TGSLGEGLPGSGAPEESDDESAAEDDDEVLIEKDAKPEKLKSRKNIDDVEDLGRIMKSSN
PEADTKPAAAPIAVDFTTYGKSASAPKKTPTNAAKEMVPKNSPTYASLTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WVVDPPELIFDGVKVNHYNKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINE
FLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERF
QRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYAQLVEKGLPCFVEIKGVTYCGTSTA
SNAGLSMSNVPFYWEVAEFVTALEKRLNEKGLKYGIAAEHAHSCCVLLASDRFYKDGKWH
PRIDYQRFFELLEERGADGDWKPEDYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A0E0KJL7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryza punctata|TrEMBL
MPPPFPTVTASTSTTSHLALLLLLSSSSVFFLYKSLRLRRLRRNQPSTSPSTDPAPTPTL
LYASATGTSKALAAGLSRRLADAGVTAHPADAAAFDPDDLPSVPLLLLVLPTHDGGAPPP
AAAFLARWLEESAADFRAGAALLSGLRFAVFGVGSRAYGETFNAAARSFSRWLRALGAAE
VVAVGEGDVDGGDLEAVFEEWCGRVLRVVKGEEIGEGHKGESNGFDELELEEEESDDDDE
EEVDGEDVDMEDIAGKAPVARRQNGKVEGALSNGGENGAREMVTPIIRTSLEKQGYKIIG
SHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGK
SWKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPERLAEGLSPRHCALSLVGEPIMYPE
INVLIDELHRKHISTFLVTNAQFPDKIKTLKPITQLYVSVDAATKESLKAVDRPLFSDFW
ERFLDSLKSLHDKDQRTVYRLTLVKGWNAEEIDGYAKLLSLGQPDFIEIKGVTYCGSSAT
SKLTMENVPWHSDVKEFSEALALKSGGVYEVACEHAHSCCVLLAKVDKFKINGKWHTWID
YDRFHELVTSGKSFKSQDYMALTPSWAVYGAEEGGFDPDQSRYKKERRHGAAALKD
>A0A2J6WRY1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aciduliprofundum sp|TrEMBL
MEEAIKLVLRKQGYMLTGENSAVKLCHWFRESILHNRPCYKETFYGIRTHRCIQMTPALN
QCTQNCLFCWRFQGFTETYLKVVDDPVQIVEGSIEAQRKLISGYGGNPDADQQKLREAYN
PRHVAISLTGEPTLYPRLGELIEEYHRRGITTFLVTNGTMPEVLENLDPLPTQLYVTVAA
PNEDIYKRLLVPLISRGWERLNKTLELLPSLDTRKVIRHTLLKGWNMEQIDEYARLDLKA
DPHFIEPKGYVYVGYSRERVTKESMPSHEDIRNFSRKLSDLTGYYFSDEREDSRVVLLEK
YRNFPKISSV
>A0A2D3C8Y3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus portucalensis|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPAPSKWDSPVEIVGSSIEGQRNLISGFGGSASRELWQQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIEPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPGHEEVLDFANQLGCELGYEVADQVEISRVVMLCRD
GKFIASKLPV
>A0A7R9P4Z3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema californicum|TrEMBL
MITIFGVPFFGASFIPTLVAVATIYIAWSWFAKKQNGNKICSLEAIDAVTTDSLSRQVVE
NGKGPLISIGDKVGPRKIVAKARKKSCGGKGGKCCGSKKGKSKCLTIEGVIDRLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEETSGQSLCVFVLPTHAEGKPP
EAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQYADHFNEVGRSVDHWLHKLQAV
RVAKLGAGDEDTAASRYGSIEADFDNWQNSLMGCVEKWRAKSNCRCGGKSPPQEERIEEA
SSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNFSSALRAARTRKESGESLGTREM
ITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFYGIESHRCMETTPSLA
CANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALDAHYKMINQFKGVPGVKPERLAEGF
QAKHCALSLVGEPIMYPEINKFVKLLHQKEISSFLVTNAQFPEAIREMSPVTQLYVSVDA
STKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYRLTLVKAWNVDELENYAKLVDIG
KPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQKLADLLPEYAIASEHEHSNCVLV
AHKKFQVDGEWMTWIDYDKFHELVQKFYSTNGESSFTALDYMRKTPDWAVYGSSEQGFDP
VETRWHRKSNTKDISGC
>A0A7H9AXN6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygotorulaspora mrakii|TrEMBL
MALNWLTACGTLFCAGLYLWLGGRKSVAMAIVVFYGAVHLDSKIERVKSTADKFIENESS
IDEEKPKKKKCCGGKGGSGCCSSKGNKKKGGCSCGHSKNADIEDIADSLESGLVVSTSQE
KDTSSGEKSTSRETNAEKRDNIIAVDFTQAFKRLSKKKGKNGKDARPRKHITKASVLKKP
KEEDDLVKSAMTVSNESLLSSQVYVFYSSLQGGAERSARKVLETLSRLIELKAPPILLNM
DDITDIDDYFVSVPCENALYILVVPSYDTDCPLDYFLQTLEENFNDFRIDKFPLRKLVGY
GILGIGDSETWPEKFCYQAKKVDHWIARLGGRRIFPVGEVCMKTEAESKVQEWADLLCET
IKDDTPILYEYDEEVTSSNEDDRPEEDMIDLEDIGNSDISGNDTKQMVAKNSPTYKKLTK
QGYTIVGSHSGVKICRWTKSDLRGTGSCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRH
GTNPVSKNWRWELDEPDYILENALQGHYSKIKQMRGVPGVVMERFAKAFKVRHCALSLVG
EPIMYPYITKFIELLHEKQISSFLVCNAQHPDALASIGKVTQLYVSIDAPTKTELKKVDR
PLFKDFWERMLQCLDILNSEQSHQRTVFRLTLVKGFNMADVSAYADLVQRGLPSFIEVKG
ATFSGSSDGNGNPLTMQNIPFYEECTKFVKEFAAELQRRGLGYGIAAEHAHSNCILIAST
EFKINGEWHTHIDFDKFFELLASGKQFYPMDYVAKTPEWALFGNGGFAPGDTRVYRKGKK
KRMMQSSEKESNETQA
>A0A1S7HU05|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces parabailii|TrEMBL
MIRLNGVTAAGTFLLTMVYLWLGGRITIALAIIVSYAILHKESNIINEQEQEKTPAKTEK
KEKKHTCCGGKGGANCCSSKAGGAGGSGHACRCSSKNKAQENKEEAKEEKGQEAASFPVA
VDFTQAFKPLKKKSTKEPKVFSKPMPFKKKAASREDDLKKSAMTVSNETLLNSQIYVFYC
TLQGTAERYANRVMAKLCTMRELKHRPTLINLDDVTDLDDYFVSVPSDNSLYILVLPSYD
TDCPLDFFLQTLEENFNDFRIDKYPLRKLVGYSILGIGDTETWSEKFCYQAKKTDHWIAR
LGGRRIFPIGEVCVKTGSEPKVNEWIDLFCETMKDDEPILYEYDESVENDGTENDEMIDL
EDIGNAEGNNSTEIKQMVAKDSPTYRTLTKQGYSVVGSHSGVKICRWTKSDLRGRGSCYK
HSLFNIVSSRCMELTPSLACSSKCVFCWRHGSNPVSKNWRWEVDEPDYILENALKSHYSK
IKQMRGVPGVVAERFAKAFQVRHCALSLVGEPIMYPYINRFIGLLHEKGISSFLVCNAQH
PDALANICRVTQLYVSIDASTKGELKKIDRPLYKDFWERMLQCLDILSTTQSHQRTVFRL
TLVKGFNMGEVMSYADLVQRGKPCFIEVKGATFAGSSDGNGNPLTMQNIPFYEEIKTFVK
KFAAELQRRGLDYDVSAEHAHSNCVLIASTKFKMNDEWYTHIDFDKFFDLLASGQDFTPL
DYVAKTPEWALFGNGGFAPGDTRFYRKGKKKTPETEKLSSADSAAFVNSTQQGQMVGETA
GSFEIA
>A0A6A9QJU0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfuracidifex metallicus DSM 6482 = JCM 9184|TrEMBL
MIHLENGQLRIDTMSRIFKELEKERYHIIGGHSAYKKCHWTHEYLVTGRSCYKGKFYGIE
SHRCVQMTPVAAWCWFRCVHCWRLEPEDIGIDWDDTKMDSFDDPEYIVNGSIEEHKRAVS
GYFGREGVKPDRVKEASQPKHVAISLTGEPTLYEKLGELIKEYHRRGMTTFLVTSGVRPD
VLASLEEEPTQLFMSLQAPNETKHKIINRAVVPNSWNLVMRTLKMLPSFSSPTVLRLTLI
RGMNMSDKDIEEFAKLIKISKPTYIEAKAYMHVGPSTYRLSRDAMPRHSEVREFSKKLEK
ITGYHILSEHVPSRIVMLSELDKPIQIGNAWNNKWDWSTRDMEDDINGEYKEAEKGCTEE
>A0A084QV26|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Stachybotrys chlorohalonata (strain IBT 40285)|TrEMBL
MDTSWPNHPQADGQVDGVLAIWHTYRTQIILLALVILLGVRVILHTKEQRQDLIVLPRVY
EKEVLDPQSSESENAKVNSTKEARKGGPRRIKGGLVKRPSDDDSAKQTEQRIKTLIFFSS
VTTKTEKFAHAYLESLQSDLKQLAEKTGKVFLEPELRDLTDIDFDDYFVSPPKLGDDVAL
LYLFLIPSYNIDTINDTFLQHLEETHHDFRIDTGSLASLLGYSVFGYGDKEGWPDEAEGF
CFQAKEIDKWMAKLTGRKRAYPVGMGDMKSDHTERFNEWASGVLEIMENVARAGNLGEGL
PGSGDAEESDIEDEGDIDDGEVLVEEDTSGDNEKIQSRTLEDVEDLGRTIQPSNGGKRSN
GPVAVDFTTYGAAEKKKAQTNVVKEMVAKNSPTYAALTKQGYSIVGSHSGVKICRWTKSA
LRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVIDPPEMIFE
GVKDNHYKKIKMMRGMPGVRAERYNEALKIRHCALSLVGEPIFYPYINEFLGMLHAERIS
SFLVCNAQHPEQLAALKAVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILREKR
FRHRTVYRLTLVKGFNVDDEVEGYAQLIERGLPCFVEIKGVTYCGTSTSTNAGLTMTNVP
FYWEVCDFVRALEKRLQEKGLNYGIAAEHAHSCCILLASERFNVDGKWHTHIDYQKFFEL
LEERGADGDWTPEDYMGPPTPEWALWGNGGFDPRDDRVDRKGRKIEPVVIRNRPQVSEIV
>A0A6A5TU13|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Byssothecium circinans|TrEMBL
MMLADLLERLPAELLALWHAHRVSVLLSAVHLSIYLWSRRHRHSVSPAPSSPVEKKDVEL
RPEWLPENTTLNAAALNLDSHAEDDVVPTVPVVRARKGPKTVKGKKASKKAPWAAPVFNH
LTDKVQPLLFFQSLSGTTEAFALACAKVLTEWTAGCDRSASFLTPKVLDLSYIEYDDYFI
GPPKAEPNVKHFYLLLLPSYNIDTVLSTFLENLSETHNDFRIDTAPLSGLLGYSVFGFGD
KEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKSDVQTRLEEWRVGVQDALVE
VAEGRGLGEGVAGSGDPAESDEEDADNIEDGVSEDNTSTTKRPKKPSARVDEIEELGSMV
DPSSSATPIPIDFTTYKPSTKSKPVPAPKEMVPTTSPTHTALTKQGYTIIGSHSGVKICR
WTKSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAP
ELIFDGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLDLMH
QSRISTFLVCNAQHPTQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDI
LRNRRFEQRTVFRLTLVKGFNMAEEVKGYADLIERALPGFVEVKGVTYCGTSAAGSAGLT
MQNVPFYEEVTAFVTALAEELAARNLGYGIAAEHAHSCCVLLADSTRFKRNGQWATRIDF
ERFYDLYEGKIEGSRVDGDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDQRVWRKGKGP
KTEKPESVDVKEPVKVVEI
>A0A8C9UAT9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
MWQSRWYGYCAGALLFALWLTVNTAREKKNAVQLANSTQHKIVKANGYLVEKEQKIYVSG
VKIFFGSQTGTAKGFARNLAEDLHALDLIAEVIDLKDYDPEDSLSDECTSKAICVFLLAT
YTDGLPTENAEWFCKWLEEASTDFRYGQTYLKGMRYAVFGLGNSVYTGHYNTVSKNVDKW
LWMLSAARILTRGEGDANVVKSRHGSLEADFGSWKARLLKRLEALVRGEKKACSGKCKKG
TCKSKGKGKVLEQSEHHSSEARIPLTTPTFFSMCGGIQDEVEDSRQELKRRKSEEEEHRE
MITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSL
ACANKCVFCWRHHTNPVGTEWRWKMDPPEIILQEALQNHQNMIKQFRGVPGVRPERFEEG
LTAKHCALSLVGEPIMYPEINAFIRLLHRQRISSFLVTNAQFPEEIRSLVPVTQLYVSVD
ASTKDSLKKIDRPLFKDFWQRFLDSLKALGEKQQRTVYRLTLVKAWNVDELKAYADLISL
GQPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRQLADLLPDYDIASEHEHSNCLL
IAHRKFNVEGQWWTWIDYERFQEFAQLYEESGGQRTFSAEDYMARTPDWALFGAKERGFD
PADTRFQRKNKTKDISGC
>A0A8C9W0B6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scleropages formosus|TrEMBL
FSCIQTGYVWRKQKLVFSPHCVHKIDQQFSSSKYLSFRGRLQIILGLIFFCFQGFARNLA
EDLHALDLIAEVIDLKDYDPEDSLSDECTSKAICVFLLATYTDGLPTENAEWFCKWLEEA
STDFRYGQTYLKGMRYAVFGLGNSVYTGHYNTVSKNVDKWLWMLSAARILTRGEGDANVV
KSRHGSLEADFGSWKARLLKRLEALVRGEKKACSGKCKKGTCKSKGKGKVLEQSEHHSSE
EQLMETSSDAESATGEEADHRSVVDMEDLGNVMNLMRKAKVRRMVEDSRQELKRRKSEEE
EHREMITPALREALTKQGSRRCFLCWRSDHSDVLLAVILQSMLRGRGGCYKHTFYGIESH
RCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDPPEIILQEALQNHQNMIKQFRGVPG
VRPERFEEGLTAKHCALSLVGEPIMYPEINAFIRLLHRQRISSFLVTNAQFPEEIRSLVP
VTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALGEKQQRTVYRLTLVKAWNVDEL
KAYADLISLGQPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVRQLADLLPDYDIAS
EHEHSNCLLIAHRKFNVEGQWWTWIDYERFQEFAQLYEESGGQRTFSAEDYMARTPDWAL
FGAKERGFDPADTRFQRKNKTKDISGC
>A0A135VEW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Thorarchaeota archaeon SMTZ1-83|TrEMBL
MPTELREKLKRQGYHLLGQRGAFKACQWQKKSLLYGDVCYKQRFYGIESHRCLQMTPVVD
KCTQNCDFCWRVTPSDLGTGWNQTSVTKNEVLAPSDLLDEVLMANLRSLGGFNPEIGANV
PENRYREAREPRHLAISLAGEPTLYPFLSELIEEGGNRGMSTFLVTNGTRPDVLSNMTLP
TQLYITLAAPDEQTYRALCKPIIRDGWKLLNESQEVLHSLSCRTVNRLTMVAGHNMYEPR
SFAKLILSGEPDFVEVKGYMFLGSSRDRMSSVNAPSHREIRSFSRKLSALTGYYLQDEQV
ESRVVLLSRSKQIKKIQ
>G8E4B8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dimocarpus longan|TrEMBL
MSSSLRARLTLVAFLSATTFYFVYKSRRLNKLLNLSLTPKTPQNPRNGKLFYISQTGTCR
TLAKRLHSRLTALGLPFDLVDPRNYEPEDLPNETLVLIVASTWEDGKPPDAAKFFADWLT
ESATDFRVGSLLLSHCKFAVFGVGSSAYEKTFNAVARDLSEKMRGLGAAEIFPVVDGDVE
DGELDAVFEDWSKRVVAVSLGDVANGGVERVVGVESDDFDDGGDEDDDEEEEVESEVVDL
EDIAGKGPSRRSVNVAETNRKLSDGKRNMVTPVIRASLEKQGYKIIGSHSGVKICRWTKS
QLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIV
NTAIDLHTKMIKQMKGVPGVTEERLTEGLTPRHCALSLVGEPIMYPEINTLVDELHRRRI
STFLVTNAQFPDKIKLRKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLTALQEK
QQRTVYRLTLVKGWNTEDIDAYFKLFSIGSPDFVEIKGVTYCGSSATSKLTMENVPWHSD
VRAFSEALALKSKGEYEVACEHAHSCCVLLAKTDKFKVDGQWFTWIDYNKFHDLVASGKP
FSSNDYMAATPSWAVYGAEEGGFDPDQSRYRKERHHKSKE
>A0A484GT78|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sousa chinensis|TrEMBL
LDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLGLPVALINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKDVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKEWQEGETSLIRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKFKI
GREWWTWIDYSRFQELIQEYEDSGGSRTFSAKDYMARTPHWALFGASERGFDPKDTRYQR
KNKSKDISGC
>A0A096MET5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia formosa|TrEMBL
LRAVPPDVHSPTENYLLWMWNNRLYVYSAAALLLGFCFLLQVTRRKVSPALDSGLKVQKA
AKNSSDEDADVHVSGVKIFYGSQTGTAKGFASELSQEVQALGIPAEVIDMKDFDPDDRLA
DECVSKSVCVFLVATYTDGRPTQNAEWFCKWLEEASTDFRYGNSFLKGLRYAVFGLGNSV
YVGHYNTVGTNVDKWLWMLSARRVLSRGEGDGNVVKSRHGSVQADFRAWKVRFLSRLRAL
ARGEKKSCSGNCKSGASCKNRKKHGAPEEEEHGSEVTENTREVELIESSSEEEESGWPDE
KTSRSVVDVEDLGNIMNSVKKAKGVKGEQGGQMVKLSKHNGVMKTEDEEERREMITPALR
EALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLAAKHCA
LSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPEEIRNLVPVTQLYVSVDASTKDSL
KKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVEELQAYAELIALGQPDFIE
VKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPHYQIACEHEHSNCLLIAHRKFK
VNGEWRTWIDYDRFQDLVQAHEDSGGQQTFSALDYTAKTPSWALFGSNEQGFDPADTRFQ
RRNKTKDISGC
>A0A5N5M530|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pangasianodon hypophthalmus|TrEMBL
MIVFFITLLTNSLSFVSSAAMPGSLDSAWLYAEAFLLAVWHNRLYVYTAAALLFGLWLTV
NMTRKKKNPVKAQTSKSEKQKEQTPEKEKAVHVAGVRIFYGSQTGTAKGFARELAEDVQA
LGFQSDVIDLKDYDPEDKLSDECTSKMICVFLMATYTDGKPTENAEWFCKWLEEASTDFR
YGKTYLKGMRYAVFGLGNSVYVGHYNTVGKNVDKWLWMMSAARVMSRSEGDCDVAKSRNG
SIQADFQAWKDDFLRRLQALAKGEKKTCSCECKKGSCKNKKKHHEESEGEKHSSEELFES
SSDPESGGEEEKAHGSVIDLEDLGNVMNHMKKAKKQVEEDPSQLRRLSKLNGLKKTEPEE
ERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQEALENHRNMIRQFRGVPGVRLER
FEEGLAVKHCALSLVGEPIMYPEINSFLRLLHQCHISSFLVTNAQFPEEIRSLVPVTQLY
VSVDASTKDSLKRIDRPLFKDFWQRFLDSLKALGEKQQRTVYRLTLVKAWNVDELKAYAE
LIALGQPDFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQQLANLLPDYDIACEHEHS
NCLLLAHHKFKVDGEWWTWINYERFHELIQQYNESNGAKTFTALDYMAKTPSWAVFGARE
RGFDPSDTRFLRKNKTKDISGC
>A0A6L2LUF7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tanacetum cinerariifolium|TrEMBL
MPATTTTTHLTLLTILSAATLYCLYKSHSLRKPKHPKPLNPNTPLNSKPTKTPKIFYISE
TNTSKNLAKHLHSILTKNNLKFDLINPETYEPEDLNTEDLVLIIASTWQDGLSPSNGVFL
SNWLNESVSDFRVGSLLLKGVKFGVFGVGSRSYGEERFNKVGKAFSSGMKALGAVEVLPI
CEGDVDEGDLDEVFGKWCEDVVRVLKLGVLENGENEELDYEEGSEYEDYESEEEEVEEDG
IVDLEDIAGKAPTRKDMEKGVVTRNGKKNGVKEMVTPVVRASLTKQGYKIIGSHSGVKIC
RWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGKSWQWQMDD
PLMIVNSALEQHKKMIKQMKGVPGVTADRLSEGLSPRHCALSLVGEPIMYPEINTLVDEL
HQRRISTFLVTNAQFPEKIASLKPITQLYVSVDAANKESMKAIDRPLFGDFWERFVDSLK
ALKDKQQRTVYRLTLVKGWNTEEVDAYSSLFSIGNPDFVEIKGVTYCGTSATSKLTMENV
PWHADVKEFSEALAQKSNGEYEVACEHVHSCCVLLAKVDKFKVDGQWHTWIDYEKFHDLV
ASGKPFDSNDYMALTPSWAVYGANEGGFDPDQARYKKERNHKTKG
>A0A0A2W0V1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Beauveria bassiana D1-5|TrEMBL
MDPLSGANGQSALFNINGGLSGLLDVWHTNRTPIILLALCGLVVLRLYIHAYEEKPDLKI
IPKIYQNTDYKNVAYKKSDNVSPPQVQEKTAVKTVGPRRIKGGVTKKPETTEESIDLNKP
VKVLVFFSSITTKTEKIGQDYIAKLEKSVAQLAAETARPILAPELLDLTEIDFDDYFIAP
PKSDDGAQFLYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSPLMGYSVFGFGDRE
GWPDEAEGYCFQAKEVDKWMAKLTARKRAYPVGMGDMKSDHAERFSEWSSGVEEVFGQII
RTGYLGQGVAGSGAPVESDDELEEDYDDGEVVFDDEKPSKRENGKSSSNLDDVEDLGRVI
KSQGGDANPRAPIAVDFTTYNNKSNPQNKVKEMVAKNSPTYAALTKQGYAIVGSHSGVKI
CRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVD
PPELIFDGVKENHYKKIKMMRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGM
LHKERISSFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCL
DILREKRFRHRTVFRLTLVKGFNVEDEAEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAG
LTMSNVPFYWEVCEFVRALDRRLQEKGLAYGIAAEHAHSCCVLLASERFHVHGKWHTHID
YDRFFELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVVREA
PE
>A0A831L480|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus sp|TrEMBL
MQSEACKALRKQGYQFFSPTSSAALKPCMWNKRALRGGDMCYKAQFYGISSHRCVQMTPT
LKCNQRCLFCWRSMEYEVVEEEECPPDVIVERLYKLQKKALAGYNPTAHKGTDEAIWKEA
LAPDMAAISLSGEPTCYSRLPELVDMLNARDFTTFVVTNGTRPWVLEKVHPYQTYISLDA
PDRETYLKVCRPMEDYWEDIHASLSLLRSRRSAIRITVVRGLNDFAPEKYAAMIQDAGPD
YVEVKGYMYLGYSRNRLERHNMPDHSEVRAFAGEIAKYCDYDRYDESPISRVVCLTRR
>A0A8H6DRC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cochliobolus sativus|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLLILLSALVVATIARLIIYSRDRREKLPTSPVPQSPIE
KQKVELKPEWLPEYTTILSSPDLNVDNHAEDDTGAVAAATKAKKGPKMVKGRKIPKKSVA
PTLTFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTGCDQASSFLEPQIHDISYI
EHDDYFVTPPKADANVKYFYTILIPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKGDAEKRLEEWRVG
VQDALVELAEGRGLGEGVPGSGDPAESDEEDVDDAEDGNGQSSRVDDVEDLGSMVNSSSS
PIPIDFTSYKKSAPKPKSATAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPEMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINQLLDIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELTSRGLQYGIGAEHAHSCCVLLADRTRFMRDGRWATRIDFERFFDL
NEGKVQGTRVEDGKVVGWRPEDYIGDETPEWALWGNGGFDPRDARVYRKGKGPKAEVEKS
EGLEVQTKKAALEF
>A0A0J9TU66|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax North Korean|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSKLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSAHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEILSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>K7G8C1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pelodiscus sinensis|TrEMBL
LDASVDVWSYFYAHLMSLWLNRFYIYTSAALGISIWICFQFITLKIKKQDEKSRQKLTQL
KVTEDVLVNGYTGPKAMKVYVAGVKIFYGSQTGTAKGFATVLAEAILSLNLPAEIINMRD
YDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCKWLEEAANDFRFGKTYLKGMRYA
VFGLGNSVYVDHYNTVGKNLDKWLWMLSASRVMTRAEGDCNVTKSKHGSIEADFGAWKAK
FLARLQALCKGEREPCSGNCKKGKCKSKGKQSKEGSDHEQRMSEQENNEVEELFETTSEE
ELGSEEDGSHNSVIDVEDLGKMMGHMKKAKKEREVEEETGRTGPFQQSIGKNEERERREM
ITPSLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILREAIENHQSLIKQFKGVPGVRVDRFEEGL
VVKHCALSLVGEPIMYPEINTFIKLLHCHKISSFLVTNAQFPVEIRNLEPVTQLYVSVDA
STKESLKKIDRPLFKDFWQRFLDSLKALAKKEKRDIYRL
>A0A2H1FHV9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotalea okcheonensis|TrEMBL
MSCSGETVKVEDEFIQIKPLILDQLKKAKYGIADHATVELCHWTKKSFKDDGQCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSALKMPVEKVAPPEVIMVNLMEERRKLIM
GHYGDPKSNKEKLDESLLPSHYAISLSGEPTMYPQLPDLIKYLKNLQNTKSIFLVTNGQE
PEMLERLRDEDALPTQLYLSTNAPNSEIFTLVNRPKYKDAWERWNTSLEMLAELDTRTVL
RFTLIKGYNADEKLIPEYVDMVTRSGAHFIEIKSYMHVGRSTNRLEYSNSPDMSEIRYFA
NELAKQSEIYSVMDESDMSRIVVLQNQKRFMDRWISSYSDTN
>A0A8H8DNP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pneumocystis sp. 'macacae'|TrEMBL
MEVLSCFLQTFSGFSKLQAKFNILEKNDFLSLKVTKNDTDDQVLKYKKIKTLKRFTISPE
RRRKMTNFLKDRFKVFQNSDQEMTDIVYITILYQTLMGSTEKYAKLLYNIVFSYFEKQVF
LENIDFVEDLDDYFVSPKNPQSHVFILVIPSYETDSPVDMLISILKDTLNDFRLDAFPLR
DLKGYTVLGLGDQENWPQKFCYQAKEIDRYLSKLGARRIVPMCYGNVKGNITNDIQTWAN
KLLNAIKNIAIPELISDISGESDNDIFEDNQDSVVDMEDIGMLMKIKKNDSNDIVIKEMV
AKDSPTYKALVKQGYTVVGSHSGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMEITPSL
ACANKCVFCWRGHTNPVGTSWRWKTDKPEDILAGVMAGHHDKIKQMKGIPGIQLERLQEA
THIRHCALSLVGEPITYPHINELIKMLHDRRISTFLVTNAQHPDALENIEQVTQLYVSID
ASTKESLKKIDRPLFKDFWERFLSCLEILGRKKLRTVYRLTLVKQFNIQEIEEYANLVFL
AKPCFIEVKGVTYCGNTNSSPLTMQNVPFHEEVVNFSKVLTEKISKIDNMPEYSIATEHV
HSCCVLIAQKKFYINDKWYTHINYDRFFELVQSKMQFSVMDYISETPSWAYFNSVHGGFN
PEDTRWRRKNAKSISLKKDLE
>A0A7D5E4S5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halarchaeum sp. CBA1220|TrEMBL
MPEQVDSPSYHHENHTAAQTCGWTANALRGEGTCYKHAWYGIRSHRCIQMTPVVRCNERC
VFCWRDHNGHAYELDGVEWDDPEAVVDASIDLQKRLLSGFGGNENVPRERFEEALDPKHV
AISLDGEPTLYPYLPELLEAFHDRGLTTFLVSNGTRPEILAECDPTQLYVSVDAPERHTF
DSVVGATEDDAWESLLDTLDVLHGKEETRTVLRTTLVNGENMTNPDWYAGLYRRADPDFV
ELKAYMHVGHSRGRLDRDSMPSPETVESFAARVQEHMPEHPVLKTQEASSVALLARDEET
WVPELAPGGGFYD
>G3PGQ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gasterosteus aculeatus|TrEMBL
PPVSQNALSPSESCLKSVWHNRLYLYSAAALVFGIWFSLKVAQKKKRFSDDPKAGKSNDS
FADTLSHVSAVKIFYGSQTGTAKGFAVELSEAVKKSGVPAEVIDIKDYDPDDQLADECTN
KSVCVFLLATYTDGQPTENAEWFCKWLQEASTDFRYGKTFLKGLRYAVFGLGNSVYVGHY
NTVGTNVDKWLWMLSAVRVMTRGEGDCNVVKSRNGSVQADFVAWKVKFLMRLQALVEGEK
KSCSGNCKTGGSRKSQRSDGETLLPSRWDEQKLSQHAQFQADPVESSSDEEESGPGAGKK
SGSVIDMEDLGNIMSRAKRAKKRFSEKNPLEDSMNGVKTIEDEGERREMITPALREALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRH
HTNPVGTEWRWKMDPAEKILQDATEKHQSMIRQFRGVPGVQPERYEEGLAVRHCALSLVG
EPIMYPEINAFIRLLHCRRVSSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDR
PLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQSYSELIALGQPDFIEVKGVT
YCGESAASSLTMANVPWHQEVVSFVQQLADMLPQYEIACEHEHSNCLLLAHTKFKVDGEW
WTWIDYERFQDLVQVQEENGGQRGFSALDYMAKTPGWALFGAHEQGFDPADTRFQRRNKT
KDISGC
>A0A6J0K2N5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Raphanus sativus|TrEMBL
MSSSSSIHARLALIALLSATTFYCIHRYRRSKRLKNHLLSSNLNPSTSSTNRIGKIFFIS
QTGTSKSLAQRLHNLLASNGIAFDLVDPRSYEPEDLPKETLAIFIASTWDGGKPPKDGEF
LVDWLSESAEDFRVGSLLLSGCRFAVFGVGGRAYGESYNAVGKELSRRMVGLGGVEMVPV
GEGDVEDGEMDGVFKDWCDGVVRVLKGGSAQETNEISQNGAVVSDGEYVDSTDEEEEEED
SNDIVDLEDIAGKAPSRKNGVVKVAKGDGKKEMVTPVIRASLTKQGYKIIGSHSGVKICR
WTKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDP
KEIVKGALDLHTKMIKQMKGVPGVTAEKLQEGLTPRHCALSLVGEPIMYPEINALVDELH
GKRISTFLVTNAQFPEKILMMKPITQLYVSVDAATKESLKAIDRPLFADFWERFIDSLKA
LQEKQQRTVYRLTLVKGWNTEELEAYFNLFSIGKPDFIEIKGVTYCGSSATSKLTMENVP
WHADVKAFSEALSLKSNGEYEVACEHAHSCCVLLGRTDKFKVDGKWFTWIDYEKFHDLVA
SGEAFTSRDYMAETPSWAVYGAEEGGFDPEQLRYKKERHHHPKPQPQVVVA
>A0A2C5ZW98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ophiocordyceps australis|TrEMBL
MVFFSSVTAKTEAIAREYMAALKGSTTQLARDSGRQFLEPELHDLSEIDFEDFFVAPPKS
VANAQFFYLFLIPSYNIDTINDTLLQHLEETHHDFRIDTAPLAPLIGYSVFGFGDREGWP
DEANGFCFQAKHLDKYMSKLTGRKRAYPIGMGDMKSGHALRFSEWAGGIHDVLGHVARTR
SLGEGVPGSGDAEESDDGEAADEDDGEAQLDLDQVGQSSADSSRPLDDVEDLGKMMGSTD
GETLPLAVDFTNYGGLFANTSTKPKATRCKTTAQLGPQVVKEMVAKNSPTYAALTKQGYS
IVGSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNP
VGTTWRWVVDAPDLIFEGVKEQHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIF
YPHINEFLALLHNERISSFLVCNAQHPEQLAALKAVTQLYVSIDASNRESLRKIDRPLHR
DFWERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAALVDRGLPCFVEIKGVTY
CGTSTSSNAGLSMSNVPFYWEVCDFARALEARLRARGLAYSIAAEHAHSCCILLASERFR
VAGKWHTHIDYERFFELLEERGADGEWTPEDYMGQETPEWALWGNGGFDPRDQRVDRKGR
RIENVVVREQPPGEVW
>M2MY98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Baudoinia panamericana (strain UAMH 10762)|TrEMBL
MDYRTIVDLPGELLYLWHAHRTEVVLTGGILVAIVRLALYWRSRKTAQLARHALSLETKQ
VPENVTLLKPPEASSTKRKVSPPSAPKRVTGRRKTRPQDAHSEAVVGKVQPVIFYYTLGG
TTKSYAEKLASALKQTDSSSSVLDPQLRDLAQIDYDDYFISAPKDVEPRTSFFYIIVLPT
YNIDTELSNFLSHLEETHHDFRIDTAPLSALAGYSVFGFGDQQEWPTEQEGFCSQAVEVD
KWMARLTGGRRAFPLGMGDVSGNVELRLAEWARGVGAIMGDLANGQGLGEGVLGSGGAAE
SADEADEVDDMNVVASAKASRKTRLTKRSTGDDLEDLKAPIPFDFTTSKSPSIAPPPRAM
VPPTSPTYSSLTKQGYTIVGTHSGVKICRWTKSALRGRGSCYKYSFYGIASHLCMEATPS
LSCSNKCVFCWRHGTNPVGTTWRWEVDPPDLVFAGMKEGHYKKIKMMKGVPGVRAERYAE
VMGTAAGQGIRHCALSLVGEPIFYPHINELLALLHKEHISTFLVCNAQHPDQLAALAPVT
QLYVSIDASNKDSLRRIDRPLHRDFWERFQRCMDILRSKRFTQRTVFRLTLVKGFNIEEE
AEGYADLVQRALPGFVEVKGVTYCGTSTAAGAGLSMQNVPFYEEVTAFVLSLEAALQRRG
LDYGIAAEHAHSCCILLADRTRFFRPAKDGGPERWHTLIDYPAFFRCLEGGETFGPEDYI
GPPTAEWASFGNGGFDPRDERVDRKGRVKVVER
>A0A673V142|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Suricata suricatta|TrEMBL
MDPSLDSWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKDKNSKDKSVP
KATRDSMPNGHIALQKKDIFVSGVKIFYGSQTGTAKGFAASLAEAVASLDLPVAVINLQE
YDPDDHLVEEVTSKNICAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMGYA
VFGLGNSAYASHFNKVSKNVDKWLWMLGAHRVVARGEGDCNVVKSKRGSIEADFSVWKTK
FISRLQALQKGEKKPCGGNCKEGQCESSAEEELVESSSEEESGVEDHENPNSVVDVEDLG
KIMNCAKKEKREKEHQEENSALVRSTGKGEGPERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQNMIKQFKGVPGVKEDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWHRFLN
SLKALAAKGVTYCGESSASSLTMANVPWHEEVVHFVRELVALIPDYEIACEHEHSNCLLI
AHKRFKIDGEWWTWIDYNRFQELVQEYEDSGGATDFSAKDYMAKTPHWALFGASERGFDP
KDTRYQRKNKSKDISGC
>A0A287A8K7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQDKNSQEKTVQNASRNL
MTNGSLSLERKEVFVSGVKIFYGSQTGTAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDY
LLEEVTSKSVCAFLVATYTDGRPTESAEWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGN
SAYASHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQ
ALRQGERKPCSGNCRKGKCESHQRGTGQAEPGPQAQEGFRRRDAEEEELLGSTSEEESGS
EDQQSGSSVIDVEDLGQVMDRVKKEKREKAQQEGETGVLRSAVKNEANEPRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPDIILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCAL
SLVGEPIMYPEINRFVKLLHECKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVSELVGLIPDYEIACEHEHSNCLLIAHKKSLS
VSADVPLMGSQIFLRTSPWTPRCGCPSNPEQGSLRMRKRGAEEPLEGERSRRGAGPPTSP
LGKSSPPNPSRRNKLSRMFTRDLIVFSPQVGGGVGAGSLCAKCLGGGGRERRPPGPDDRG
GVPRGCTSHWDRDLVICLEL
>A0A8D1MVU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sus scrofa|TrEMBL
MDPLDTWDFSSPLISLWINRFYIYLGLAFGFSLWICFQIVIRKQEVFVSGVKIFYGSQTG
TAKGFAAILAEAVTSLDLPVAVVDLKAYDPDDYLLEEVTSKSVCAFLVATYTDGRPTESA
EWFCKWLEEAASDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVM
ARGEGDCDVVKSKHGSIEADFTAWKAKFISRLQALRQGERKPCSGNCRKGKCESHQRGTG
QAEPGPQAQEGFRRRDAEEEELLGSTSEEESGSEDQQSGSSVIDVEDLGQVMDRVKKEKR
EKAQQEGETGVLRSAVKNEANEPRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPDIILKEA
IENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINRFVKLLHECKISSF
LVTNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQR
TVYRLTLVKAWNVDELQAYAQLVSLGSPDFIEVKGVTYCGESSASSLTMANVPWHEEVVR
FVSELVGLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYNRFQELIQEYEDSGGSK
TFSAKDYMARTVVCNLIS
>A0A7C5EBN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
RLARAGYRIVGRHSAVKVCHWTKRSLLDRGVCYKEEFYGRELGVRSHLCLQMTPSIWFCD
HRCLHCWRDTSVTVGGWEGEADDPSLILDLAVEAQRSLLSGFGGNPAVNRRKLEEARNPR
HCAISLAGEPTLYPRIGDLIEECGRRGMTSFLVSNGMHPEVLERIPSPSQLYVSLLAPDE
ETYRRVCTPLIPDGWARLLRSLEILSGLGGRTAVRVTLVKGLNMFDAGGYSSLILRGEPD
FVEVKGYMWVGYSRSRLKLENMPSHADVKEFAEQIARETGYEVAGEQQASRVVLLKR
>A0A7R7VSU9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus chevalieri|TrEMBL
MSTPIRKCGNQSTPRVSNPKNSIFFRFDQKWFNAASAVISVKGDLQSDAGSISRERPVYI
CDALSGFYQSLLDLISERTESSTLMDCSNAMLEGAVTFWHAYRLPILVTLSTLFVIIQAY
RKLQPKSKTEASSSLPPSPRSHSPEKSEKIPVNDGTKKGTPVFSKSTGPKVVTGKKPVKG
GKRGSDEPQPLSFIQPIVFFASLTGTTERYAHMLVEELRAAAQNRADPENRERGLLPPQL
HDLSYIDFDDFFTSAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDT
GSLSQLAGYSVFGFGDKEGWPTEEEGYCSQAKELDRWMAKLTGKKRAFPLGLGDVKDNAE
QALKEWSHGLQDILYDILQNGGLGEGVPGSGDPLESDEEDLDDEDETDVAKPKSKRGKGQ
SSTVVDLEDIKVNPDSPAPLAVDFTTGGKSSEPQAKEMVPKTSPTYAALTKQGYSIVGSH
SGVKICRWTKSALRGRGSCYKFSFYGIKSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTW
RWKVDDPDMIFNGVKDGHYKKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHIN
RFLDLLHSEQISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWER
FQRCLDILREKRNVQRTVFRLTLVKGFNVEDEVIGYANLVEKALPCFVEIKGVTYCGTST
SAGAGLTMQNVPFYEEITEFVIALNKELERRGLNYGLAAEHAHSCCVLLASDRFHVNGKW
HTRINYERFFELLEKEKADGTSFAPEDYMSETTEWALWGNGGFDPNDERVYKKGKKAKAQ
QAQQQLTNSTPNEA
>A0A497F5W5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MKVIEEMKKIYMKQGYHFIGKYALIKPCHWLRRSLITKGIQHCYKQKFYGIPSHRCLQLS
PTIACTQRCLYCWRVQAADLGLVWNDYVIKDYDNPEDIVLNGILMQRQILSGFKGNPKVN
AEILEEAFRPIHAAISLVGEPTLYPRIGELIAAFFRHGFKTTFLVTNGTLPEALSNIECE
PSQLYVSLSAPNENIYRKLCRPKISDGWKRLKESLEILGSFSCPTVIRITLVKGWNMQNP
EEYAKIIDKAEPTYVEVKAAMSLGGSRLRLPIESMPKHEEVKAFGMKIGEAASYNLIDEA
VESRIILLSKLEKPIKLI
>A0A524A7N2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSVPEELRRVYRKQGYHLVGGHSAVKTCHWVRRSLNTGGQEHCYKQRFYGVPCHRCLQMT
PSLGRCTQSCLFCWRATPEAIGVPWDQTRFPESEAEDPETIVEGCIQAHRKAISGFGGNP
NVQETMWEEAENPLHAAISLEGEPTLYPCLGELVEAFFGKGFESVFIVTNGLNPEALSDL
GTEPTQLYVSVCAPDEETYERTCRPLIPKGWGNLMESLELLRSFSCPTVLRHTLVPNLNM
KDPAGYARLAELSGATYLEPKAAMSVGFARNRFGYHEMAWHDDVRRFAEELARESGYSIL
DEQPLSSIVLLSRLPKPKKLY
>A0A497M8P8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MIPDEAKDRFLKAGYRIVGRHSAVEVCHWTKESLRSGRVCYKEKWYGIKSHRCLEMTPAL
IWCTHMCLFCWRPLKYTVCGEPEADDPEEIIDGCIEARRLLLTGFKGNVKVDRRKWEESI
RPTSAAISLAGEPTLYPRISELLEAFKKRGFTTFLVTNGTRPDRLRGLSTEPTNLYISLC
APDEETYKRVNRPLIPDGWMKLNESLELMKSFKCRTVLRLTLVKGLNLKDPEKYAELILK
AEPDFVEPKAFMHIGEAQGRLPRSAMPTHSEILEFSKTLSRLTGYRIKDEAPQSRVVLLS
KT
>A0A523TBH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLLRQKYHLVGNHSAVKRCRWLYNSIVQDRTCYKQKFYGIKSHRCLQMTPSVFHCTLSCV
FCWRAQSGDHDLRWDETRLPEWNEPEEIIDGCIREQKRILTGYKATPNADQNKRLEAVTP
KHAAISLTGEPTLYPHLDGLIKGFHRRGFTTFLVSNGTVPETLSNLSEEPTQLYISVSAF
DKKKFSQVCRPNVPDAWEKLNETLSLLPSFKCPTVIRFTLARHLNLEYPKLFAQLVRKAN
PTYLEPKAYMHVGFSRLRMDYSNMPTHREIKDFAAQLSTEMGYNLLDEAPDSRVVLLSRL
EKAIKLA
>A0A2J6MZU3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MIGRHSAVKRCRWFYETLIHNRPCYKQKFYGIKTHQCIQMTPALFYCTQQCLFCWRAQSG
DLKLTWNETKLPRWDPPELIVEESIKAQLKILSGYKGNPKANKQKFEEASNPRHVAISLT
GEPTLYGPISDLIKEFHRRNFTTFLVSNGTLPTVLAKLDEEPTQLYISACAPDKETFKEV
CRPQIPEAWEKLNATLELLSSFKCPTVIRITSVKGLNMKNVEGYAKLIDKASPTYIEPKA
YMHVGFSRLRLGFENMPSHQEIRDFAQKIAEETGYNILDEAPESRVVLLSKLKQAIKFSS
NYASLK
>A0A7J2NMB2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQSLVPEEIVRMLQRQKYHLVGSHSAVKRCRWLYNSIVQDRGCYKQKFYGIKSHQCLQMT
PSVFHCTLRCVFCWRAQSGDHDLRWDETKLPEWDDPETVIEGCIREQKRILSGYKANSEA
NQKKRREALTPKHAAISLAGEPTLYPHLDGLIKGFHRRGLTTFLVSNGTVPETLSSLSEE
PTQLYISVSAFDKKTFTKVCRPHVPDAWKKLNETLELLPSFRCPTVIRLTLARHVNLEHP
EVYAQLIRKANPTYVEPKAYIHVGFSRLRLGYSNSPTHPEIKEFAAQLADEMGYNMLDES
EDSRVVLLSRLEKPIKHA
>A0A2I3GFH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nomascus leucogenys|TrEMBL
MKLSVCVILNLDPSVDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGFATV
LAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNLCVFLVATYTDGRPTESAEWFCKWLE
EASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCD
VVKSKHGSIEADFRAWTTKFISQLQALQKGERKKSCGGHCKKGKCDSHQHGSEEREEGSH
EQDELYHRDTEEEEPFESSSEEEFGDEDHQSLNSIVDVEDLGKIMDHVKKEKRETEQQEE
KSGLFRNMGRNEDGERRAMITPALREALTKQVDAPRERRGGCYKHTFYGIESHRCMETTP
SLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFE
EGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVS
VDASTKDSLKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLV
SLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVQIACEHEHSNCLLIAHRKFKI
GGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERGFDPKDTRHQR
KNKSKAISGC
>A0A7J3TXP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MASQKDTLESFKQTLLKQGYRIVGKHSGVKICEWTRKSLTQGRYCYKQKWYGIESHRCLQ
CSLALFWCLNRCLYCWRSFRIFLGAEMDVEPDDPEWLLDGLIKAQRELLTGYKGNVKVER
SKWEEAQNPTNVAISLIGESVLYPYLSEFIELAEKRGMKSFLVTKGTYPEGLEKLSVEPT
NLYISVCAPDEETFNRLERPIKRNGWEAQMKSLELMKSFNCRKVIRITLVKGYNMDNIRG
YAKLIEKAEPDYIEPKAYMRVGESIRRLPEDAMPSCEEVLEFAEKLASEIGYVVKDLFKP
SRVALLSKNKR
>A0A2H9NSX4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon CG_4_10_14_3_um_filter_37_21|TrEMBL
MDENLKKLLEKQQYRFSGNHSVVKICRWTKKSLVEGKVCYKEKWYPPVKSHRCMQMSPSL
VCNHRCLFCWRLHSGDRGFSWKESFEGLVLDEPKDILEKCIEQRKSLLTGFKGFERVDKR
KWEEALKPNMMAISLTGEPTMYPKLDELIQEAKRMNIISFLVTNGTLPDRLQSLNTKPFQ
LYVTLPAPNKETYKKLCQPSTPKLWDKIMETLELIDSFDCRKVIRLTLVKGLNMVEPEEY
AKLIEKANPDFVEAKGYVHVGESQKRLPMDAMPYHEDIIEFSKEIEKHSSFRIKDVFKPS
RVVLLKK
>A0A7L3S5S7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cepphus grylle|TrEMBL
LNVSMDMWNFSYTCLVSLWLHRFYIYSVVAFGISVWIIIQLFTTKTKKKGEKSNGSPASL
EGIKDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKKFATGLAEAVISFNLPVEVISMGD
YDPDDCLAEETTSRNICVFLVATYTDGQPPESAAWFCKWLGEAANDFRFGKTYLKGLRYA
VFGLGNSVYVDHYNTVGRNIDRWLWMLGASRIMTRAEGDCNVAQSKHGSIESDFEAWKAK
FLTWLQALCRGEKKPCSGKCKKGKCKSSRKQSKESSDHEHRASEHENTEAEEFETSSEEE
ADAEEAGGTNAVVDVEDLGNIMSHMKKAKVLLLERDPACAFRRVFSRSCDVEMALRRPSD
WFLNMFSPVLIYFLFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEAT
PSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRF
EEAMTAKHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYV
SVDASTKESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADL
IALGKPDFVEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLVPDYEIACEHEHSN
CLLMAHKKFKVDGEWCTWINYGRFQELVREHERSGGAKTFTAADYAARTPRWALFGSRER
GFDPLDVRYQRKNKARDISGC
>A0A126QWT4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|methanogenic archaeon mixed culture ISO4-G1|TrEMBL
MDEDYRNLLIKQQYRIYKDHAAVKLCHWMKESMLHERHCYKQDFYGIQSHRCLQMTPAIN
ECSHLCSFCWRVQNNDFEVTDWAEPKEMLDALIEEQRKLIQGFKGDPRCDPDRFKEAMNP
NQVAISLAGEPITYPYLSDFIKECHSRGMTTFLVTNGTYPDRIRELEHLPTKIYVTVAAP
NEEIYRKVCRPKIRDGWQKLMETLELMPSLETGTVIRHTLVKGHNLGWIDDYARLDKIAD
PELIEPKGYVFVGGSRQRLSMDCMPSFQEITDFAEQLGSKVGMEIIRKREDSRVVLLGHP
GQDTIVRP
>A0A8I3MMI6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus familiaris|TrEMBL
MDPFSDTWDFSSPVISLWINRFYIYLGFAFGISLWICFQIVIRKQLFILKGKKSQEKSVP
KATGDLMTNGCISLQNKEVFVSGVKIFYGSQTGTAKGFATSLAEAVTSLDLPVAVINLKE
YDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIEADFRVWKTK
FLARLQALQKGEKKPCDGNCKRGQCESSVEEEPSESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSERRTMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKIGREWWTWIDYNRFQEL
VQGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A534JDA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPAKREVLERQGYKVVGEHSGVKVCHWTKSSLTRGVGCYKETFYGIKSHRCLQMTPAVD
SCNLGCLFCWRTQEWGSDSLVHADDPGFVVEESIQAQRALLTGFKGNPKVSTEKFQEAWH
PNQVAISLTGEPTLYRRLGEMIDEFHRREMTTFLVTNGTTPAVLRRMAAEGRLPTQLYVT
VAAPNAEVYRKLMAPKSEHEWEKLNETLALLPSLDTRTVIRHTLVEGWNLGWEDEYAALD
AIAEPMFVECKGYSFVGESRLRLRVENMPEHAVIRQFAGTLGERLGYKIAAEREDSRVVL
LTHDGALYPISEGNPGRAPK
>A0A2D6VUU4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNDKVPREKFLEAQDP
KHVAISLNGEPTLYTRLGEYMDLCHKHGMTTMLVTNGTLPKVLENLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWDQFEKTIDLLPSLDTRIVCRHTLMKGVNMSSTHIKEFAELDN
RADPDFIEAKGYVYVGHSRENLSMENMPSHDDILSFSNELAPQVNREVLSESRPSRVALI
GREIVPIPIPEAELYFPEDLGIAPPVKKLPLIQN
>A0A2E3S3K4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPQIAAKLSKQRYHLVGEHGGVKVCHWTKEELKNDRHCYKGTFYGIQSSGCMQMAPNVD
TCNLACTYCWREPHSETMTKIDDDPEMLFYESVRAHRRLLTGFKGHKDVSIEKWEEAQNP
KHVAISLNGEPTLYSRLAEFLEICHDHGVSTFLVTNGSLPRTIERLDTLPTQLYVSVDAP
NKEIFNKLCKPKFNSNSWEQLEKTLELLPSLDTRTVCRHTLIKNHSLGFHEDYARLDNMA
DPDFIEAKGYVYVGHSQNNHTISDMPTHAEVMEFSQTLAPMVGREVLADRSESRVSLIGK
EIIPVVLPEQKRAFPTDLGIAKPQAFKLPTV
>A0A2E3V1Z6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPKIAARLAKQSYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDALTKIDDDPYELFLQSVKAHRRLLTGFGGHPSVPREKWLDAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NKEIFDRICKPKFDQSAFEKLEQTLELLPSLDTRTVCRHTLIKGESLGHWKDYARLDNLA
DPDFIEAKGYIYVGNSQSNHTIENMPSHDEVMDFSRNLAPLVGREILSDRRESRVALIGK
EMIPVTLPKKIRDLPKDLGIAKPQKFSLPQL
>A0A2D6ACH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVKSHNCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLSEYMDLCHKHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNSNAWDKFSETLDLLPSLDTRIVCRHTLMKGINMSKQHVKEFAALDM
RADPDYIENKGYVFVGHSRENLGVENMPSHEDIMEFSNAIAPLTQREVLSDSRPSRVALV
GREITPIPIPQPTMFFPDDLGIAPSVKHLQMANV
>A0A2E3MBK5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGVASHNCMQMSPVVD
QCNLACSYCWREPHMDSLQLTDQDPLEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHAHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKKVFDEICRPKWNAAAWDKFEKTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRALAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMQFPEDLGIAQSIKHLKIVQ
>A0A2E1LAA0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKVLENLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNSRAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDKHIEQFAALDN
RAEPDFIENKGYVFVGHSRENLSAENMPSHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GHEITPIPIPEPTMFFPDDLGIAPSVKHLPIIQ
>A0A519D070|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGIASHSCLQMSPVVD
QCNLACTYCWREPHMDSLELADQDPLDMLYESVRAQRRLLTGYGGNDKVNPAKFQEAQNP
MHVAISLNGEPTLYSRLGEYIELCHKHGMTTMLVTNGTLPKAIENLDTLPTQLYVSVDAP
NKQVFNKICKPKWGAAAWEKVEQTIDLLPSLDTRIVCRHTLVKGENMAKEHIAQYASIDN
RADPDFIECKGYVFVGHSREVMTIENMPRHEEIMEFAGELAPMVGRKVLDDSPPSRVALV
GNEIIPIPIPEQTMFFPEDLGIAKPIKHLPMA
>A0A2E5XQA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPRIAAKLAKQRYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVRAHRRLLTGFGGNPKADREKWLDAQNP
KHVAISLNGEPTLYSRLGEFLDICHQHGTSTFLVTNGSLPKVIESLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQSAFYKLEQTLEILPSLDTRTVCRHTLIKGESMGHHEDYARLDRLA
DPDFIEAKGYVYVGNSRNNLSIENMPSHDEVMEFSQELAPLVDREVLSERRESRVALIGR
EMIPVKLPEKIRDLPKDLGIAKPQNLSLPTL
>A0A534MN35|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDSQKQEVLERQGYRIVGEHSGVKLCHWTKASLTKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLACQFCWRTQEWGSDSMLLADDPGLIVEDSIRAQRELLSGFKGNPNVTRERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDEFKRRNMSTFLVTNGTTPATLRRMHAEGRLPTQLYVT
VAAPNEEIYQRLMVPRSGNEWRKLKETLALLPSLPTRTVIRHTLVEGWNLGWEDEYADLD
HIAKPMFIECKGYSFVGESRLRLEAENVPSHASIRTFAERLANRIGYRVAAEREDSRVVL
LTADGELHPLSR
>A0A1N7CJ57|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronorubrum thiooxidans|TrEMBL
MSNSAETGVDAGSDAEQNEGDGDGGAMQVSSPDYHSENHTAAQTCGWTANAIRGEGKCYK
NIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASLKLQKRL
LSGFGGNDDVPREVFDQAMEPRHVAISLDGEPSLYPYLPELIEAFHDRDITTFLVSNGTR
PEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWEKLLETMAVLADKDETRTVLRTTL
VKGENMHHPDWYAGFFQQADPDFIEMKAYMHVGHSQGRLDRSAMPDHEEVVEFTERVGEY
MPEFTECKGVPASRVALLSKTNDTWVPKLKKDSEFWARDSVTGN
>A0A6A6AFV1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dothidotthia symphoricarpi CBS 119687|TrEMBL
MALLYDLGQLPNELLLIWHTHRVALLLSAVALVTVVRLAIYLRGQREKVSVSPAPASPVE
KKLVELRPEWLPENTTLNVSNLNLDDHAEEDAIAVATIVKAKKGPKTVKGKKISKKIATP
APSFDHKTDKIQPLVFFQSLSGTTERFAAQFAKVLTEWTTGCEQSASFLEPQTFDLSYTE
FDDYFLSPPKAEPNVKHFYFILLPTYNIDTVLSIFLESLQETHNDFRIDTAPLSGLLGYS
VFGFGDKEGWPTEEDGFCSQAREVDRWMARLTGRKRAYPLGMGDVKADADARLQEWRTGV
QEALVEIAEGRGLGEGVRGSGDAAESDEEDIDDAEDSNGQTTRVDDVEDLGSMVTSSSTA
IPVDFTTYKSAPKSKSTTGPKEMVPTTSPTYASLTKQGYSIIGSHSGVKICRWTKSALRG
RGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPDLIFDGIT
AAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLEIMHKSRISTFL
VCNAQHPAQLAALVPVTQLYVSIDASNKESLRKIDRPLHRDFWERFCACLDILRNRRFEQ
RTVFRLTLVKGFNMAEEVAGYADLVERALPCFVEVKGVTYCGTSAAGSAGLTMQNVPFYE
EVAEFVTHLEKELASRGLTYGIGAEHAHSCCVLLADRTRFQRDGRWATRIDFERFFDLYE
GKAQGTRMENGAVVGWRPEDYVGGETPEWALWGNGGFDPRDQRVYRKGKGPKTEDGGGGG
EQAGKKVDAAALEF
>L0HM98|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aciduliprofundum sp. (strain MAR08-339)|TrEMBL
MDPEVEKILRKQGYAIVGKHSAVKLCHWLRESLLHNRPCYKQTFYGIRTHRCLQMSPAVN
NCTQNCLFCWRFQGFSEVYMKEVDDPEFIVEESIRQQRRLLTGYKGDPRVDLEKWKEAME
PRHVAISLTGEPTLYPRLGELIEEYHRRGFTTFLVTNGTMPEVLENLDPLPTQLYVTVAA
PNEEIYKKLLVPLIRNGWERLRRTLELLPSLNTRKVIRHTLVRGWNIGYEEEYAKLDLLA
EPDFIEPKAYVFVGYSRERLTIENMPRHEEIREFAKKMAEITGYRYEDEREDSRVVLLMN
ENTQRFLSS
>A0A2H3I3W1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Penicillium sp. 'occitanis'|TrEMBL
MADSPFVPGFLATWHNFRIPIIVSLAVFFLFVRFIGSKRSKSPSSSSLPPSPRLESAIPK
EKPVAPILDQTAVTEVKPTPKPVASGPKRVVGNKDRRGGKNTQKSAELSGPSFIKPVIFF
ASLTASTQTHARWLSEQLRTAAQEKSPGNDEEWGLLPPEIYDLAEVDFDDHFITAPKPPA
NSPNTRYVYCFLIPTYNIDTIIDTFIAHLDETHNDFRIDTAPLSSLAGYSVFGFGDKEGW
PTEEEGFCSQAKEIDRWMAKLTAKRRAYPLGMGDTKTDALDCLKDWTSGLAEILLEVAQT
GGLGEGVAGSGDPLESDEESAAEDEDEPSTKKSQTVVDLEDINFGASTKKSKADPIPVDF
TTVSKSQTSQMTLKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNGVKEGHYKKI
KMLKGIPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHTEQISSFLVCNAQHP
DQLATLHRVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILREKRHVQRTVFRLT
LVKGFNIDDEVKEYADLVEKGLPCFIEVKGVTYCGTSSSAGVGLTMKNVPFYEEVVAFVL
ALNNELERRGLGFKVDGKWHTRIDYDRFFELLEKEKTEGIAFRPEDYMRETEEWALWGNG
GFDPNDQRVRKVRDKKPKNDQPAE
>A0A1D2VLA9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ascoidea rubescens DSM 1968|TrEMBL
MMERFTLLCDLVVVGGSGLYCCTGGRLTVGLLAVVLYFCVGRASLKTAHLDNDSQIGKPA
PIVVEKPVSEIGLEKGVIEKPTTLVANSDVRAVQIKPRTKKKRVAKVIKARPPVKSSEKS
NQPIDYLNSNIVIFYSSLTGSSQRNAKYLYDKLNDSKALKNRATLLNLDIDIDDYDNYFF
TVPEKLKNLIYILVLPSYETDSPIDYFIQTINDNANDFRIDKYPLRKKIIGYSVIGIGDK
EHYGGDKFCYQAIQVDQILSKLGGNRIFPLSKFCIKYDTDTKIKEWIDFLVENLLSEEPL
SYSNESESTSGKINLSNYNDNGNSDYENGEDEYNNNEFSDNESNSSNTDQSLIDVEDMGK
YSASSADVQNNLSFNSNSNLNSNSRDIIVPEVKEMISKDSPTYKALTKQGYTIVGTHSGV
KICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTSWRWQ
VDGPELILKGALEGHYKKIKQMRGVPGVKPERFQEAFRVRHCALSLVGEPIFYPYINEFV
GMLHEKEISSFLVCNAQHPEQLRNLKKVTQLYVSIDASTKSSLKKVDRPLFKDFWERLIS
CLDILNSVQKRQRTVFRLTLVKGFNMGEVDGYVDLIERGQPSLIEIKGATFCGSSSGNGN
PLTMQNIPFYEECRRFVIAINEGLRAKGLDYDIAAEHAHSCCILVAQKRYCIDGKWFTHI
DYKRFFELLREKGQEFDEMEYISETPQWAYWGSKEAGFNPDDVKFSRSEEKAKNRAIREA
AAAEAAEAARQEANEIDINLAMAAQ
>A0A667HSQ3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lynx canadensis|TrEMBL
MDPSLDTWDFSSPLISLWINRFYIYLGFAFGISLWICFQIVIRKQLFIFKGKNSKDKSVP
KATRDLMTNGYISLQKKDILVSGVKIFYGSQTGTAKGFAASLAEAVTSLGLPVAVINLQE
YDPDDHLVEEVTSKNVCAFVVATYTDGRPTESAEWFCKWLEEASSDFRFGKTYLKGMRYA
VFGLGNSAYANHFNKVGKNVDKWLWMLGAHRVMARGEGDCDVVKSKHGSIEADFRVWKTK
FISRLQALRKGERKPCGGNCKKGQCESSAEEEPFESTSEEESGTEDHQNLNSVVDVEDLG
KIMNCVKKEKREKEHQEEKSILVRNAVKGEASERRAMITPALREALTKQGYQLIGSHSGV
KLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILKEAIENHQSMIKQFKGVPGVREDRFEEGMMVKHCALSLVGEPIMYPEINRFL
KLLHECKISSFLVTNAQFPVEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLN
SLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTM
ANVPWHEEVVHFVRELVALIPNYEIACEHEHSNCLLIAHTRFKIDGEWWTWIDYNRFQEL
VQEYEDSGGLTNFSAKDYVAKTPLWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A2I4CXK2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Austrofundulus limnaeus|TrEMBL
MLILLSMISLFAGFASPSDIKDPEDVQSSELNCLMWVWTKRLYVYSAAALLFGAWFLLQV
VHKRKSSTEAAASQESRSAKNKIRSEVHVSGVKIFFGSQTGTAQGFAKDLSEEVKALGIP
AEVIDMKNYDPDDRLADECVSKSICVFLVATYTDGRPTDNAEWFCKWLEEASTDFRYGKS
FLEGLRYAVFGLGDSVYVGHYNTVGTNVDKWLWMLSARRIMTRTQGDCNVVRSRHGSVQA
DFQAWKVRFLSRLQALARGEKKSCGGKCKKGGSCEKKKKRQEEEEKASSQNDSEVDLIDT
SSDEDEPGSVDERKSGSVVDVEDLGDIMSSVKKAKALLLVAGKQLNGAELPPAGKVDEEE
EEGQTVKLSKLNGVRKTEDEEDRREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDS
LEKHQHMIRQFKGVPGVKPDRYEEGLEVRHCALSLVGEPIMYPEINAFIRLLHRHHISSF
LVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQR
TVYRLTLVKAWNVEEMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVA
FVQQLADMLPQYEMACEHEHSNCLLIAHTKFRVNGEWWTWIDYERFQELVXAHEDSGGQR
SFSALDYMAKTPGWALFGAQEQGFDPEDTRFQRRNKTKDMSGC
>A0A0B0DWW5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neurospora crassa|TrEMBL
MPFEIPGLNPAAIAEVARYAVELWHEHRIPILLSTVFLLGLLRTYLHLYSEPRQELLVLP
KIYEPNEKTKETTLVETEVKDKKTGAAITKKAKTAKGGPKRIKGDKVRTKKGTNGNDTGS
ESEGPRKIQVLVFYSSLTGNTERYTKDFAKELGDLLVGQSDAESKAESNFLAPQVLDLAE
IDFDDYFLSPMKGPVDYFYCFIIPSYNIDSINDTFLAHLDETHNDFRIDTSPLASLIGYS
VFGYGDRDGWPTEEEGYCVQAKQVDRWMAKLTGRKRAFPLGMGDYKRDGKERLSEWQNGI
VDVLKMIEQTGSLGEGIPGSGDPFESDEEDIAEDDGEVVYEESESKKTLEDVEDLGRIIK
QTQGDGQAAPIAIDFTDFGKTGKTVHARKSATVTVKEMVPKNSPTYTSLTKQGYSIVGSH
SGVKLCRWVKSAMRGRGSCYKYSFYNIVSYCCMEATPSLSCSNKCVFCWRHGTNPVGTSW
RWVVDPPDLIFNGIKENHYKKIKMMRGVPGVISSRFTEALRIRHCALSLVGEPIFYPYIN
ELLGMLHKERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNKDSLRRIDRPLHRDFWER
FQRCLDILRERRFRQRTVFRLTLVKDFNIEDEIEGYADLVERALPCFIELKGVTYCGTST
AGAAGLTMANVPFYQEVCDFVVKLNDALNKRGLGYGIAAEHAHSCCVLLASDRFKVDGKY
HTHIDYEKFFDLLEEKGPDGDFTPEDYMGAAVPEWATWGNGGFDPRDQRVDRKGRPIERP
>A0A8H7PJT6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mortierella isabellina|TrEMBL
MSELVNNIISGFKNIVSFGSEEASSNANSGCCGGNSDGQTACCNSGSAPKDAESGGCQVN
ESGCACSSSNEPSNIDHVKIFYSTLTGTAKKFAEQLETQLNSNPGNVNIEKVTVMDIVDY
DNDDFMAETAVCLFILSSYNVEGPLDWFSKWTQDLRYDWRVDRLSLQKIRFAVCGLGDSE
YGEEFNAASADIDKWFGQLGASRIYPLGSCDKSADQQAQFNSWVSGFISELQDAHSLEFH
PSNIAYDSDDEGEEVDDGELNKDIGAGDDNLSGDEMVDVEDMGKMASKIRAAKVNRAEEE
EAYDNGKSRAKRSIGNTAEPTAAPVPRDMVSPMLHKNLTKQGYKIVGSHSGVKICRWTKA
ALRGRGFCYKHSFYGIQSHLCSESTPSLACANKCVFCWRHHTNPVGKTWRWKVDDPEFIV
QGVLENHYKMIKQLKGVPGVKAERFQEAFDVKHCALSLVGEPIFYPHINEFIKKLHERRI
STFLVTNAQFPEKIAELEQVTQLYVSVDASTKESLKKIDRPLFRDFWERFLSSLDSLATK
GQRTVFRLTLVKDYNTDELANYVELIRRGRPSFIEIKGVTYCGYSGASNLTMANVPYHTE
VIEFCRKLVEAIGGGYELAAEHAHSCSILIASTDFKIDGEWYTHIDYPKFFELLESGKPF
NSLDYVAKTPSWALFGAPEAGFDPNETRFYRKGKNPNQDTTTEVAVAV
>A0A250XFR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chlamydomonas eustigma|TrEMBL
MPWPFSWFKSSKTDKGSIVNVVEETQPKSESINEGTISNIAKTAVTSDNCERGEGAFTSC
SKDAQDCSSSTTACACSSFKTSPSPNLKALNQQSTPQLLILYGSQTGMSKAFAEQLAVAC
KLALASQAEFEDIQCMDMTKFEPERLISDLPEGSVFLIVVSTYEGGTPPDAARWFCRWLE
DAAHDFRVGSSALLERKIRYAVFGCGNSLYGDNFNAVAKRVDSQLSTLGGVSVTDVGLGD
EDTGKLTLQFQEWSNKVIAGLSQDQNSKQSGGSSQNKEVQTQQEGTTSDNYEDTDDDEEE
DLGGEDVDMEDLGGVAPKKAKKSSTRLRDAADADSKHGGERSIVVSAPEMLTPIVSAPEM
LTPIVRASLTKQGYKLIGTHSGVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLA
CANKCVFCWRHHSNPVGRSWKWAMDGPVDIVDQAVSLHQRMVKEYSGVPGVVAERVAEGL
QIRHCALSLVGEPIMYPEINGLVSELHKRHISTFLVTNAQFPDRIKQLSPVTQLYVSVDA
ATPESLKAIDRPLFSDYWERFTACLSCLKEKQQRTVYRLTLVKGWNMAEVQQYASLIDLG
QPDFIEIKGVTYCGDSGASSLTMQNVPYHVDVREFGQAICNARNGEYGLACEHAHSCCIL
LARTDRFLIDGRWHTWIDYEKFQQLVRSGKSFTTQDYLAETPAWAEYGSNEAGFDPIQQR
VKKERKHPGKSSNNNIAETEI
>A0A139Y6N3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Toxoplasma gondii ARI|TrEMBL
MWTSGYLDPRLSSVLSKYGGDVFSRESDPPHVQHNSGSTGDALSPPEQQDVRRIQESETQ
PWEPESPTTNGEAPFRILILFGSSGGTSAAIAFSLFHSLCLQLRREEDAYMPSADFPVQE
PHSGEKTFVKESKGPQPNGVDLEGGADSEKGDWTGISSSEHIQEVAGDSASASDSLASPQ
ACGARVNGQKGKCQRRGDRRERGQSGNEKKGREALDSSDFFSDGGRAAETALGRARRRVK
ETQEPVASGLSSRKLWFLDRAYSGGVEVLIQSMEFFSFDDLLALSEGSALPFEASQGISS
NQRSTAASHLIPPLSCSPPGYSSAFLSASVNSASSSSPTRLLILFCLATGAQGSPPSTAA
AFCAEAEEATKDFRVGKNTLSRCFVAGIGCGSSEYPRPTFCRPAKTLFRNLTGHLGALPL
LFLPLTSQGASAPLSAPSTHRASSAVSTSSSSSLLLLSDTHTERSLEAKVKNWEGEVLRR
LVAFLKASRKEQIRLLSRATEQKSGKPKELSGKAGRKAGAAECRAGSHELPGAETIDERH
RMHAIGDERATGEGNDIATKGGDRELQSAVFSEDSHSSSDSGGESSDRSSLFSSDDNEDG
EAPGWSPGLSVFASGKEASQSPCGTPEGNADLEDMVECGRDARPRSEGGPGSRGSAARGK
KGKSAEKKAMVSEKQAAQLKKEGYKLIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGITSS
QCMELTPSLACANKCVFCWRHHKNPVGTSWRWQLDNADFIVEEGLKNHFAAIKELKGMAE
VNEERLASARAEVRHCALSLVGEPIMYPRIAELVKLLHHQHISTFLVTNAQFPEALRTLP
PVTQLYVSVDAANPKDLKTLDQPLFADYWERFLSCLDLLKEKRQRTVYRLTLVGGYNMDD
PSASVSKECHTGAKPRGSSAAASAVGENSINEVERMCCRSATSGNKDDYAETACGCLSPR
TEGGQEKSPGEETPQSRAAIREEITGEKADKERGKAKTEGQSLTDRSAAAYARLVLRGSP
DLIEVKAVTYAGTSKHSKLTMKNIPWHDEVVAFCQTLCDALPTGDYAIACEHRHSCCVLI
AKTS
>A0A667YXE8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
MCTFGASATTTRVLVFLLCVVKDVCTLDTKGPEDAHRAPEGCLMSLWHGRLYLYSAVALG
FGIWLSLQVAFKKKSFAKQVGPWVCKAVRTSGPSQEKDAVLHVSGVKIFYGSQTGTAKGF
AKDLSDDVKALGIAAEVIDMKDYDPDDRLADECSNKSVCVFLVATYTDGQPTENAEWFCK
WLEEASTDFRYGKTYLRGLRYAVFGLGNSVYVGHYNTVGKDVDKWLWMLSGMRILTRGEG
DCNVTKSRNGSVQADFQAWKVKFLSRLQDLAKGEKKSSTGSCKSGSGSCKSRTKRSQGQS
EEEKAALHDNFEAELVESSSDEEESALPEESQSGSVVDVEDLGRIMNSVRKAKSRDEGRG
DGQMVKLSKVNGVKKIENEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRG
RGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKILQDAL
EKHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRISSFL
VTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEKRQRT
VYRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAF
VQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSGGQRS
FSALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A667YT23|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
LLYFSLLLYGFAKDLSDDVKALGIAAEVIDMKDYDPDDRLADECSNKSVCVFLVATYTDG
QPTENAEWFCKWLEEASTDFRYGKTYLRGLRYAVFGLGNSVYVGHYNTVGKDVDKWLWML
SGMRILTRGEGDCNVTKSRNGSVQADFQAWKVKFLSRLQDLAKGEKKSSTGSCKSGSGSC
KSRTKRSQGQSEEEKAALHDNFESSSDEEESALPEESQSGSVVDVEDLGRIMNSVRKAKV
RDGQMVKLSKVNGVKKIENEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLR
GRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKILQDA
LEKHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRISSF
LVTNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEKRQR
TVYRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVA
FVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSGGQR
SFSALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A8C3T3N5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chelydra serpentina|TrEMBL
MDASVNTWSFFYTHLMSLWLNRFYIYSCAAFGIGIWICFQFITTKAKKQDEKSTQKLTPS
KVTQDVLINGYTMPKTKEVYVAGVKVFYGSQTGTAKRFATILAEAILSLNLPAEIINMRD
YDPDDCLAEEATSKNICVFLVATYTDGHPTENAAWFCKWLEEAVNDFRFGKTYLKGMRYS
VFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEGDCNVTKSKHGSIEADFDAWKAR
FLTRLQALCKGEKKPCSGNCKKGKCKSKGKQSKEGSDHEQRVSEQENTEVEDLFETTSEE
ESGAEEDGSRNSVIDVEDLGKIMSHMKKAKKERELEEEAGRTGPSQQRSGNNEESERREM
ITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPEMILREAIENHQSLIKQFKGVPGVKVDRFEEGM
VVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTNAQFPVEIRNLEPVTQLYVSVDA
STKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYAELVSLG
KPDFIEVKGVTYCGENAASNLTMANVPWHEEVVHFVRELADLIPDYDIACEHEHSNCLLI
AHKKFKIDGEWCTWIDYDRFQELVQVYEKSRGSKTFTAADYVAKTPHWAVFGSRERGFDP
LDTRFQRKNKTKDISGC
>A0A1Q7GCK8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thaumarchaeota archaeon 13_1_40CM_4_38_7|TrEMBL
MSCSGETMEVSSEFIQIKPMILNQLKKAKYGVSDHGTVELCHWTKKSFRNEGDCYKHKFY
GISTHRCMEFSPAGMFCENRCVYCWRPMEFYSAMKMPPDKVAPPDVIVTNLIGERRKLIM
GHYGDSRKDEKKLDESLLPNHYAISLSGEPTMYPQLPQLIKYLKKLPTTKSVFLVTNGQE
PDMLQRLHDEDALPTQLYLSTNAPNYEIFQLVNRPKYEDAWERWNTSLEMLSKLDTRTVL
RITLIRNYNCSDELIPEYAEMIRRSNVHFIEAKSYMHVGRSTNRLEHSDMLEMSEVRYFS
LELAKQSKIFSIMDESEISRILVLQNQKRFMDRWIAAYANTN
>A0A179IER5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cordyceps confragosa|TrEMBL
MDPLGGAHGQSALFNINGLLDVWHTNRTPIILVAFCGLLLLRLYLHVYEEKSDLKTIPKL
YEKLAPQKPENVSQREVQAKAAVKTVGPRRIKGGMAKKPETSEEPIDLTRPVKILVFFSS
ITTKTEKIGQDYIAKLEKSVAQLAADTQRRVLAPELLDLTEIDFDDYFIAPPKSDDGAQF
LYLFLIPSYNIDSINDTFLEHLQETHHDFRIDTAPLSSLLGYSVFGFGDREGWPDEAEGY
CFQAKELDKWMAKLTARKRAYPVGMGDMKSDHAERFTEWTSGFEEVFGQIIRTGYLGQGV
AGSGAAVESDDEAEEEEYDDGEVIFDDEKPAKRENGKSSSSLDDVEDLGRVIKSQGGDAN
PKAPIAVDFTTYNNSKASSQSKPKEMVAKNSPTYAALTKQGYAIVGSHSGVKICRWTKSA
LRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEMIFD
GVKEGHYKKIKMMRGVPGVRAERFAEALKIRHCALSLVGEPIFYPYINEFLGMLHKERIS
SFLVCNAQHPDQLADLKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFNRCLDILREKR
FRHRTVFRLTLVKGFNVEDEVEGYARLIEQGLPCFVEIKGVTYCGTSTSSNAGLSMSNVP
FYWEVCEFVRALDTRLKEKGLGYGIAAEHAHSCCVLLASERFRVDGKWHTHIDYDRFFEL
LEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKKEAIVIREAPE
>A0A4R8RLC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Colletotrichum trifolii|TrEMBL
MAISLDQPGLMAMLNDFHDVWQQVRIPVILFTLFGLFVLRLYYHSTEKKGELKALPKVYN
REKPETEPKGLAVDEKQVVNEIVAVGKKELKPTPVAEPKAAKSSGPKRIKGGLVKRPSEE
LKNSEVAQTIRPLIFFSSITANTPKIAKEYAERLGKDLEKTATDTGCQFKTPEVLDLAEI
DFDDYFITPPKSEEPVELFYLFLLPSYNIDTINDTFLEHLQETHHDFRIDTAPLSSLLGY
SVFGFGDREGWPTEEEGFCFQAKQVDKWMAKLTGRKRAFPVGMGDTKRDYSERLAEWSEG
VVDVLGLVAKTGSLGEGLPGSGAPEESDDESAEEEDDEVLVEEDAKPEKLKNSSKLEDVE
DLGRIMKSSQPDSAPAPAAPIAVDFTTYGKSTTATKKPTQAAKEMVPKNSPTYASLTKQG
YSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGINSHQCMETTPSLSCSNKCVFCWRHGT
NPVGTTWRWVVDPPELIFDGVKANHYTKIKMLRGVPGVRAERFAEAMRIRHCALSLVGEP
IFYPYINEFLGMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPL
HRDFWERFQRCLDILREKRFKHRTVFRLTLVKGFNVDDEVEGYARLVEKGLPCFVEIKGV
TYCGTSTASNAGLSMSNVPFYWEVSEFVTALEKRLNEMGLKYGIAAEHAHSCCVLLASDR
FYKDGKWHPRIDYQRFFELLEERGPDGDWRPEDYMGEATPEWATWGKGGFDPRDERVDRK
GRKIEA
>A0A7R9GXN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Timema cristinae|TrEMBL
MITILGVPFFGASFMPTLVAVVTIYIAWSWFAKKQNGNKICSLEAIDAVTADTLSRRVVE
NGKGPLISIGDKVGPKKIVAKTRKKSCGGKGGKCCGSKKGKSKCLTIEGVIEGLKVFYGT
QTGKSKVFSTILAKSAEEKSLPVELVDLSTYDPEDKLTEETSGQSLCVFVLPTHAEGKPP
EAAAWFYKWLQEAAHDFRVERALLKGMKYAVFGLGNSQYADHFNEVGRSVDHWLHKLQAV
RVAKLGAGDEDTAASRHGSIEADFDNWQNSLMGCVEKWRAKSNCRCGGKSQPQEERIDES
STAEDGEIEVRISASSCDSQSDAGEASDSEWDSDPSQEVKSAVLDMEELGNFSSALRAAR
KRKESEESLGTREMITPLLRESLTKQGYKLIGSHSGVKMCRWTKSMLRGRGGCYKHSFYG
IESHRCMETTPSLACANKCVFCWRHHSNPVGTEWRWKMDQPEEILAGALYAHYKMINQFK
GVPGVKPERLAEGFQAKHCALSLVGEPIMYPEINKFVRLLHQKEISSFLVTNAQFPDAIR
EMSPVTQLYVSVDASTKDSLKKIDRPLFRDFWERFVDSLKALSEKGQRTVYRLTLVKAWN
VDELENYAKLVEIGKPDFIEVKGVTFCGTSKASNLTMENVPWHEEVVSFVQKLADLLPEY
AIASEHEHSNCVLVAHKKFQVDGEWFTWIDYDKFHELVQKFYSTNGESSFTALDYMRKTP
DWAVYGSSEQGFDPVETRWHRKSNTKDISGC
>A0A6B2CLZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldivirga sp|TrEMBL
MRYHEFADGRIVISRDALTTLKKAHYGVYGHATVELCHWTKSALTGGPSCYKVKFYGAPV
GGSHRCVEMGPVGMMCSNKCIYCWRPSESFDPYEPGYGEVMSPEEIINGVLKERRRLLSG
YFGHSRSSRGKVLEALQPTHWAISLSGEPTMYPRLPELIKAIKALPNTKSVFLVTNGLYP
EMIERLWREDALPTQLYLSLNAPNRELFYKIANPVIHRDDAWERVLRSLELLSKIPTRTV
VRITLIRGWNTMEDLIPQFAEVLGIGNPHFIEPKSYMNLGHSVYKLTKDNMLRHSEVREW
SMMLLKALRDKGMDYVFMDEDPNSRITVLQNMKRYVDRWIEKPTNP
>A0A7K4AGU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix soehngenii|TrEMBL
MQDTMAEKALARQGYHLVGSGAVKPCLWLNRSMRGGDQCYKNHFYGIASHRCVQMTPTLE
CNHLCLHCWRPIDDPIPGKEPMEPAELLEGILRGQQRFISGYGGSSTTDPVRLEEAREPK
HMAISLMGEPTLYPYLKEFIDLVSRRGMTSFLVSNATRPEVLAELRPTQLYLSLNAPDEE
RYRQICNPSKDLWPRILESLELLKEHRCRSVIRMTLVRGQNMEGLDDYARLIGDAEPDFV
ELKAYMHLGRSRTRLERTAMPQHSEILALADSLAGLLGYHPEADVPLSRVALLSRGRISR
FIEMRDHK
>A0A2H9L1T4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_59_7|TrEMBL
MMIAADDAARLRKAGYVIVGSHSAAKVCLWTKRALLDRGFCYKQKFYGISSHRCLQMTPT
LPFCTQRCLFCWRDTRLFSTKWEGEADEPAGIIDGCVDAQRLLLNGFKGNPDINLAKFKE
AQNPNQAAISLDGEPTLYPQIGEMIAEFKRRDFTTFLVTNGTNPKTLASLPVLPTNLYVS
SCAPDEATYKKVCAPTIRNGWKRLNETLALFPSLKTRKVMRLTLVRGLNLKDADGYAKLI
AKAEPDFVEAKAYMALGASRLRLGPDYMPTHEEIRAFAKELADASGYKYKDEQTESRVVL
LCK
>A0A317XEP9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus sclerotioniger CBS 115572|TrEMBL
MAETPAAEGLLAFWHSYRLPLLLALATAVVLLRAYRKVQPKSKIASASSIPSSPRSHSPE
KSEKIIHNEKEIGKESNAQVVEESVAEKESAKPGPKRVTGKKPAKVAGRRRGSDQEPAAS
FIQPIIFFASLTGNTERYAKVLLEDLRAAAADRADPENRERALLPPQIHDLSYVDFDDYF
ITAPKPPTTSPGTRYVYCMLVPTYNIDTVLNTFLGHLDETHNDFRIDTAPLAGLAGYSVF
GFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFADVKSDPESALKEWSSGLKD
ILGDIVDSGGLGEGVPGSGDALESDEEDLDDESDSKANKKRNKGQSVVDLEDIKFSSETG
SSAPVPVDFTTGGQQPAPATEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGV
KEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSF
LVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHV
QRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFY
EEVQQFVTSLNKELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLE
KEKADGTSFTPEDYMKETEEWAMWGNGGFDPNDERVYKKGSKKKAIQAAAEAQG
>A0A6F9DWQ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phallusia mammillata|TrEMBL
MFMILLAAIIGVVVYGLIIQVLKFRSQKFYKKAFESKFVNIFYGTQTGTAQRFALKLEKA
LADLHIACKTHSLDDFGFEDNYGEMIGNGTAIFIISTYSDGNAPVNSKWFYKWINETSND
FRIQKCMLKGLQYAVFGLGDSAYTSNYNKVGKNVDKWLHKLGATRIYPFGEGNEHASHSL
HGSQEKDFHAWMVVITDVLVALLKKREWSMEKVGDLEKKSRLSIEDLDESDDAPEELPDD
LVDVEDVADTVYQQMSNSNKINGVAVKAITKKKNLKEMITPELRKNLSKQGYRLVGSHSG
VKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKW
KQDPPQLIVEEAIASHYDMIKQFKGVPGVQPKRFSEGFSIQHCALSLVGEPILYPEINEL
IELVHEKGISSFLVTNAQFPDAIRDLLPVTQLYVSVDAATPESLKKIDRPLFNDYWPRFI
QSLKSLSSKGQRTVYRLTIVKSWNNEEIESYAKLVSLGNPDFIEVKGVTYCGNSSSSDGL
TLRNVPWHEEVLYFVGLLAELLPGYEIACEHEHSNCVLIANTKFKQSNGNWKTWINYTRF
HELFQQYKETGQTFEAHEYSDVTPKWAIYGSEERGFDPCETRWKRKQKVSHGC
>A0A8C9CQ71|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Phocoena sinus|TrEMBL
LDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQGFATVLAEAVSSLDLP
VAVINLKEYDPDDHLVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKT
YLKGVRYAVFGLGNSAYVNHFNKVGKNVDKWLWMLGAHRVMSRGDGDCNVVKSKHGSIEA
DFTAWKARFISRLQALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQ
EEPFGSTSEEESGTEDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKSE
AGERRAMITPALREALTKQGESPQELLACANKCVFCWRHHTNPVGTEWRWKMDQAEMILK
EAIENHQNVMKQLEVFIERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHERKISSFLV
TNAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTV
YRLTLVKAWNVDELQAYAKLVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFV
CELVDLIPDYEIACEHEHSNCLLIAHKKFKIGREWWTWIDYSRFQELIQEYEDSGGSKTF
SAKDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>A0A8J4NGP6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eudyptula minor|TrEMBL
LDVSMDTWNFFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKVTEHASTFVWE
DPKNLCVEVRIEDKLVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVISLNLP
VEVISMGDYDPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGKT
YLKGLRYAVFGLGNSVYVDHYNRVGRNIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEA
DFEAWRAKFLSRLQALCRGEKKPCSGKCKKGKCKSPGKQSKESSDHEHGASEYENTEAEE
LFETSSEEEADAEEAGGTNSVIDVEDLGDIMSHMKKAKSGLDSRVGGGMYHPFPRLSINP
IRTRLLAVQGGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTA
KHCALSLVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDAST
KESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKP
DFIEVKGVTYCGESSASNLTMANVPWHEEVVHFVQELANLIPNYEIACEHEHSNCLLIAH
KKFKINGEWCTWINYDRFQELVQEHERSGGSKTFTAADYAARTPLWALFGSRERGFDPLD
VRYQRKNKARDISGC
>A0A7R8ZIV2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprideis torosa|TrEMBL
MEILGLPLYGDFTGVLAAVILVFLGVIYWLQKRASEEESKVNVVKEDSASMAMAQNDITE
KPEAASTTTTKSQDDDASPSPRRSQKQKRVVTRATGDVRNEEKKVHGCSTGGKCCGECRT
PKSGRKTVPVASPIDKIRIWYASQTGTAEGFAQTLLQYVESTGLEVSVESLSKVEEPLDR
MAEEAIPGTLNLFLVSTYTDGKPPEACDWFFQCLQDDASDFRVEKGSLQFFQFGIFGLGN
SLYEDHYNKVACDLDSSLSSLAGRRVLALTLGDENTAKAKYSVEESFRKWMTEKVMKLIL
ESQEQEKDDEENLQLPSPRVEAVSTEASDESSEEDHGARPSGGGLVDLEDLGQFIAMPLR
GEGAPAEDKEMLTPALREALSRQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIQS
HQCMETTPSLACANKCVFCWRHHSNPVGTKWKWKMDQPQKILDGALVNHYRMIKEFRGVP
GVLSERYQEALEARHCALSLVGEPIMYPEINAFLDLLHEKQISSFLVTNAQFPEQMRSLR
PVTQLYVSVDASNPQSLKKIDRPLFRDFWERFLNSLRALSEKGQRTVYRLTLVKSWNAEE
IEGYASLVELGQPDFIEVKGVTYCGTSKASSLTMENVPWHEEVIRFTEELVAKLPGDKYA
IASEHEHSNCVLVAHKKFFVNQEWHTWIDFEKFHELNERWRATGGQHGFKVEDYMSPTPS
WAVYGHEERGFDPEETRWRRKQTSRDVSGC
>A0A6J3GQT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sapajus apella|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIKKQDRNLQENSFPKATQD
LMTNGFVSLHNKDIFVSGVKIFYGSQTGTAKGFATVLAETVVSLDLPVAIINLKEYDPDD
CLIEEVTGRNVCVFLVATYTDGRPTESAEWFCKWLEEASRDFRFGKTYLKGMRYAVFGLG
NSVYASHFNKVGKNVDKWLWMLGARRVLQALQKGERKKSCGGHCKKGKCESHQHGSEERE
EGSEEQDELHHRDTEEEEPCEGSSEEEFGGEDQQSINSIVDVEDLGKIMDHMKKQKREKE
QQEEKTSLFGNTGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRG
GCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIEN
HQNMIKQFKGVPGVKAERFEEGMMVKHCALSLVGEPIMYPEINSFLKLLHQRQISSFLVT
NAQFPAEIRNLKPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAAKQQRTVY
RLTLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVL
ELVDLIPDYEIACEHEHSNCLLIAHKKFKVGSEWWTWIDYNRFQELVQEYEDSGGSKTFS
AKDYMARTPHWALFGASERGFDPKDTRHQRKNKSKAISGC
>A0A6B2CAU8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcales archaeon|TrEMBL
MDTSRIIDHYTEINRSLRKQKYHLIGGHSAVKKCLWTHKVLMDNLYCYKGKFYGIDSHRC
IQMSVSTQWCWNACLHCWRIRPTDILEEWDERRIPEIDDPEFIVEMSIIEHRRTVSGYKA
HNVDPNKIAEAINPRHVAISLTGENTLYPALGELIKEYHKRNITTFLVTRAVRPDIIANL
DEEPSQLYISLEAYDKEGYEYFNTPLVPRAWEKTLETIEILPSFTCPTVYRITAVRGWNM
SLEAAKGFAKLIERGEPTFVEVKAYMYVGTSTKRLGRENMPSHEEVKEFARILSEISGYK
IVSESRPSRVVLLSKLEKPLIRHGNAPVTWWDPDLTDFSEYEISENIYGEITTK
>A0A3B3YXL3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Poecilia mexicana|TrEMBL
MWNNRLYVYSAAALLLGFCFLLQVTRRKVSPALVTSDEDADVHVSGVKIFYGSQTGTAKG
FASELSQEVQALGIPAEVIDMKDFDPDDRLADECVSKSVCVFLVATYTDGRPTQNAEWFC
KWLEEASTDFRYGNSFLKGLRYAVFGLGNSVYVGHYNTVGTNVDKCLWMLSARRVLSRGE
GDGNVVKSRHGSVQADFRAWKVRFLSRLRALARGEKKSCSGNCKSGASCKNRKKHGAPEE
EEHGSELIESSSEEEESGWPDEKTSRSVVDVEDLGNIMNSVKKAKLILCSAVFSEIFTHQ
HVFPPSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIRQFRGVPGVKPERYEEGLAAKHCA
LSLVGEPIMYPEINTFLRLLHSHRISSFLVTNAQFPEEIRNLVPVTQLYVSVDASTKDSL
KKIDRPLFKDFWPRFLDCLRALGEKKQRTVYRLTLVKAWNVEELQAYAELIALGQPDFIE
VKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPHYQIACEHEHSNCLLIAHRKFK
VNGEWRTWIDYDRFQDLVQAHEDSGGQQTFSALDYTAKTPSWALFGSNEQGFDPADTRFQ
RRNKTKDISGC
>A0A5D6YDV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pythium brassicum|TrEMBL
MVRVVGLTPAAAAGVTVLLTATLALSVAYYVASQRSAHLEHQQKATLAAKRITSKVAKQP
KARAKKASAASSSSPSSPPPPMPVRILFGTQTGTAKRMAEELEKKIFALNIAGFHFQTSI
VSMKDYDQDNLEHEGVVIAILSTWTGGAPPQDARVFCNWINDMALDFRVSKSWLQKTSHA
VFGLGNAEYDEFYGTAAKNLDRELSALGSPVLCPLGLGDDNVDQFHQFEQWADNLVAAMC
ELSSEQQAAPAGATLGGESKQWLSQKEFRRQKKAKQQQLEVESGEAVELNEEDFMNEKVL
TGEFSDDDDDDDDDDGDRADGAVTKPTSGTSGDASGGMVDVEDLGKSMKESEAANLSREM
VTPMQRKALLKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQCMETTPSLA
CANKCVFCWRHHKNPVGRVWRWKTDDAEVLVKGSIERHQHMIKELKGLPGLIQARWDEAF
TVRHCALSLVGEPIMYPHINEFCRELHKRRISSFLVTNAQFPEKIAALEPITQLYVSVDA
ATKDALQAVDRPLFKDFWERFLACLEQLKRKGQRTVYRLTLVKSYNMDELDNYAELITIG
QPDFIEVKAVTYCGKSDGSDLTMKNVPWHDEVRDFCAALCARVSGSYGLATEHAHSTCVL
LAKKKFCIEGQWHTWIDYDRFHELVQQYYADGAEFTADDYMAPTPAWAVYDAPERGFDPV
ETRFRRTKDGKVVEFAYEATDSGCG
>A0A1E7GGJ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina sp. Ant1|TrEMBL
MSLEEKKEDIGENILEVQQEDRNEKQTSFPFDIPDFKTLLKKQGYALAGHHSAVKTCLWL
RHAMNGQGFCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEIPVPDLGEWDHPEKIV
KESIACQRKLITGFGGSPNAIKERWIESNEPNNVAISLSGEPTLYPYLPELIEEYEKRGF
TTFLVTNGTVPEMLAKVSPSQLYMSLDAPDLETYLKVCQPKSAALWEKINESLSLMKQKN
SRTVIRTTLVKGQNMFKPEAYAELIKKASPDFVEIKAYMHLGFSRLRLDRSSMPTHAEVL
EFSQELAKYLEYEIADESEISRVVLLSKDGKKSPVKKVSGLD
>A0A7J2Z1T8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MLYLILNVLLFLNIIISSDFMIPENTLSLLKKQKYRLAGNHSLVKICQYTRDSMTKDSWC
YKNKFYGIRSNQCLQCTTVPYCFNRCLFCWRAQPGEGSDVNEIKIEEWDEPEKIIDEMIK
TQRLLLAGIGGHYNVDKKLWKEAQNPRHVALSVLGEPIVYPKLMELLHEFKKRKMSTFLV
TAGSAPGAIENMLKHKVFPTQLYLSMGAYDKESFEKIMRPTTPNGWERYVKSLELLNDAG
KYTRTVIRMTLIKGLSLKNQEQYAKLIKMAMPHYVEVKAYMAVGFSRKRIGLTGMPLQDE
IREFAEKLAKETGYIYTDEHLPSRIVLLSRDEKAKNERIIDFEKI
>A0A3Q2PZH5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fundulus heteroclitus|TrEMBL
MQQSVVARAYKHNMSRVFFIFLFLYQLADLRLVVCAESFHQIVLLRRLTFGNIDKNRVRL
QHLFHVLLPGRKQQINRFIIVFFYLKDQPKTTEKNIIYLSPTFNTCKEFYASENTRVLKF
ESDSRSGSPAHGFIFVAGDLECVSRSVCVFLMATYTDGRPTENAEWFCKWLEEASTDFRY
GNTFLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAQRIMSRGEGDCNVVKSRNGS
VQADFQAWKVKFLSRLKALARGEKKSCSGSCKSRGSCKNERKHRADEEENAASQDNGSEA
DLIESSSEEEDSVLAEDKRSRSVVDVEDLGNIMNNVKKAKGVKEDQVNGQMVKLSKLNGV
TKAENEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRYATTATCNNVGTSWRMKELYNLLSPLTSFPPGVPGVKP
ERYEEGLAVRHCALSLVGEPIMYPEINTFLRLLHAHKISSFLVTNAQFPEEIRNLVPVTQ
LYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEELQAY
SELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHE
HSNCLLIAHTKFRVNGEWWTWIDYERFQELVQAHQDSEGQQSFSASDYMAKTPRWALFGA
KEQGFDPTDTRFQRRNKTKDISGC
>A0A812F390|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis uzonensis|TrEMBL
MSCSGEFVEQDDLIQIRPSIAKQLKKAKYGVADHATVELCHWTKKSFKGDVGCYKHKFYG
ISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLQMDPGKVAEPKQMLEKLMEERRKLIMG
HYGDPKSDRKKLDESLMPSHYAISLSGEPTMYPKLPALIRYLKSLPATKSVFLVTNGQEP
HMIQRLVDEDALPTQLYLSTNAADRESFMRINKPRYADSWERWHNTLQIMSNLNTRTVLR
MTLIRDYNDSLHDIEAFASMIKNSGIHFIEIKSYMHIGRSTNRLERTNMLEFAEVQHFAT
ELAKKSGVYSVMDDSESSRIVVLQNQQKPIDRWIAAYR
>A0A662IBR9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoprotei archaeon|TrEMBL
MSVSRLSPEDVRRYLRAGYRLVGRHSAVEVCRWTKTALKGGHLCYKRWYGVRSHRCVQMT
PVLNFCNFACIFCWRPHLSGRFKIPPGWEWDEPSEIIEGAIRAQRELLIGFKGNPKVTRE
RFLEAMFPRHMAISLDGEPTLYPKLAELIKGVKARGMTAFLVTNGSVPHRLEELIRKGAE
PTNLYISVYGPNPEVFEKAARPLIPRAWELVLESLDLIPRFSCRTIIRLTMVKGLNMVEP
EGYAKLIERSQPRFVELKGYTWVGESQKRLPREAMPTLEEIERFAKKLEELTGYQIKVSD
SKSRVVMMVRDEETWEWNLKLLEEWRELERRLDSEWRGRIRDFRLKRQPA
>A0A832ZB92|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus okinawensis|TrEMBL
MSTYIPEEIYGILRKQRYQIKDHSAVKLCGWVKKSLLENKSCYKSKFYGIETHRCIQCTP
AVIWCQQSCIFCWRVLPSDIGVSQLYHDNIKWKEPEEVLEDILKMHRKVVMGYKGILDRI
GKRRFKELLNPRHVAISLSGEPTLYPYLDDLINLFHKKGLSTFVVSNGILTEVIQEIKPT
QLYISLDAYDLESYKKICRGREEYWQAILETLDTLRSKERTCIRTTLIRDYNTDIEKFIP
LYERAEVHFIELKSYMNVGYSRRRLTLEHMLKHEEILELARRVEALSHYKLADDSFDSKV
ALLVNEERRIERFIC
>A0A7J4PS02|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanotrichaceae archaeon|TrEMBL
MEYFPNQITERLKRQGYHLVAHGAVKPCLWLKRSIRGGDQCYKNHFYGISSHRCVQMTPT
LLCNHRCLHCWRPIDDMPDTSGEWIEPTEILDGVLFEQQRLISGYGGAPDTTDSARLEEA
KSPAHVAISLMGEPTLYPMLKELIEEIKSRGMTAFLVTNGTMPDVIGEVRPTQLYLSLNA
PDEKTYLKVSNPQSNLWSRFLESLEMMRDSPSRTVARLTMAKNLNMQDPQGYAKLIEIAE
PDFVEVKAYMHLGSSRNRLERDSMPTHEEVMDFANDLSEILGYRLANHVPISRVALLSRG
SEQEKIEP
>A0A5E4JX50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MKRNFDDIKSDLENKKYAVVGNSSGVQICNWTKKALKEEGGCWKQKFYGIKSAGCCQFSP
SLMWCEHKCVHCWRPIELSLGNKLDKVDDPIEILDKIVLARKKLMMGFKGLDKVNKKKFQ
QACEPSLYSFSLSGEPTIYPRLDEMLREIRKRKAISFLVTNGQNPEMIRKLDGASSLPTQ
LTLSTNAPNKELYVKWHNSCNKDAWERFTETIGVVGDLKGKCRRCIRLTLVKPGKDSRFK
LTEPNKLAQSQTQGFAKDITNMTEELVGDYTNLILKADPDFVHVKGFTSIGYARNRMGTD
KMPWFIEVRKYAKKILTQLNKSDKNWKLLASDKKSCVVVLSKLEKKDMKIRTF
>A0A5E4I3L2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MARRRKKEAEKTKYFKEMREQAEAIPQELLKKLLRQKYHIVGKHSAVKMCQWTASTLKGE
GSCYKNAFYGIQSHQCIQSTPVLLFCNHACVFCWRMMPEEGLKFSDMPKKGFSWDAPKEI
VEGFVQAHRKTVSGFGGNPKTGGKVFEEANSPKHVALSLTGEPSMYPYMGELLEEFHKRG
ISTFLVTNGTYPNMVEKWKTLPTQLYVSLVAPNKEVYLKAIRPDSPVLWEQYLKTLEMLP
ELGKKTRTVLRMTLVRDVNMQPIEGYAQQILLAKPHYVEVKSMVFVGGARLKERGLSTGS
MLGMEEIREYAKELAKLTGYIYAAEHAPSRIVLLCKDEKALKSRMIDFSKI
>A0A5E4KGP4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MTTISDSTKVLLKKHGYHLAGTHGAVKTCLWLNKSLRNEGSCYKSQFYGITSHRCIQMTP
TLVCNHRCLHCWRAVEAPVEIPEKWDSPQDIVESCLAGQRKLVSGYGGSEIMEKTRWKEA
FAPKHVAISLSGEPTIYPYLPELIEEFNKKDLTTFVVTNGTNPGTVGDIKPTQLYISLNA
PDKEAYGKVCRPLGDTWENIKQSLEVMKDSKSRTAVRITLTRGVNMSAPEGYARLIEAAE
PDYVELKAYMHLGFSRMRLSRDNMPSHQEVLEFSREVALALGYLIADESEASRVVLLSKD
GEKKNIV
>V4CQI9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lottia gigantea|TrEMBL
MKVFYGTQTGNSKKFAEILAYEYELRGYGTEVVDLKTYDPEDNLVEENANGNICVFIIST
YTDGQPPEGASWFYKWLTDTSDDFRVQKTLLKGLYYTIVGLGNSVYKDNYCTVAKKLDKS
LHDLSATKFSETIFCDENTVNSLNGGLESDFAAWRENFWKKAQPALNGRKVKDCGKKCDG
KCACSKPGVDGQEAGPCSSDEGSGEEENQFNSKNKSSPNKVKPANKTSGVVDLEDLGKIM
KKAKICIILYKRKKLFFFQQNKDIEETGEVREMITPLLRQSLEKQGYKLIGSHSGVKLCR
WTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWKWKMDDA
ETLIAGALKNHTKMINEFKGVPGVIPERFQEGMNPQHCALSLVGEPIMYPEINKFIDLLH
EKHISTFLVTNAQFPDAIRELTPITQLYVSVDANTKETLKKIDRPLFKDFWERFIECLKR
LGEKGQRTVYRLTLVKAWNTEEIENYAKLVDLGRPDFIEVKGVTYCGDSKASSLTMENVP
WHEEVIKFVTDLTDRLPDYEIASEHEHSNCLLLAHKKLKVKGEWWTWIDYPKFHELISEY
TLSNGKKTFTTEDYMAKTPPWAVYGATERGFDPLETRHHRKKQKDISGC
>A0A5E4K309|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured archaeon|TrEMBL
MIPDKIKKLLKKQHYYLVGKHSAVQICRWTKKSLLDEGICYKEQFYGIKSHLCCQMSPAV
MWCPNRCLHCWRAIEMTIDNELKGNVDSPKEIIDGCIKAQRELLIGFNRDEKSKKKQLSR
ANMKKYLEAQEPMQFAISLSGEPMVYENIGGLIEEIRKRGKTSFLVTNGLYPEKLEELKK
AKQLPTQLYISVNTPNEELYKKFHRSLKKNAWELLNKSLEIMSKLKGRRTVFRMNLVKNL
NMNPEMAEEYAEMIKEANPMFVEIKGFMSVGFARERLGYERMPYHQDIVDFSKRILKFLP
KYKMLDEKKESRVVLLGKNKKDMKIKKEEY
>A0A7L0CRJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rostratula benghalensis|TrEMBL
LEVSMDTWNFFYTCLVSLWLHRFYIYSALASGISIWIIAQFFTTKTKKKGNPASSEGAED
KLLNGLGTLQAKEVFVTGVKIFYGSQTGTAKKFAAGLAEAVISLNLPVEVISMGDYDPDD
LVDETTSRSICVFLVATYTDGEPTESAAWFCKWLGEAATDFRFGKTYLKGLRYAVFGLGN
SAYIHHYNMVGRRVDKWLWMLGASRVLTRAEGDCNVAQSKHGSIEADFEAWKTKLLSRLQ
ALCRGEKKPCSGKCKKGKCKSSRKQSKESSSHEHQASEHEDTEAEELFDTSSEEEADAEE
AGGTNSVVDVEDLGNIMSHVKKAKVSLLEQVQNVRDLSPIIKIDGLIYFSFPGYRLIGSH
SGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGTEW
QWKMDQPEMILREAIENHQNMIKQFKGVSGVRADRMEEAMAVKHCALSLVGEPIMYPEIN
QFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDASTRESLKKIDRPLFKDFWQR
FLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYAELIALGKPDFVEVKGVTYCGESSASN
LTMANVPWHEEVVHFVQELADLIPDYEIACEHEHSNCLLIAHKKFKVDGEWWTWINYGRF
QELVQEQERSGGSKTFTAADYVAKTPRWALFGSRERGFDPLDVRYQRKNKARDISGC
>A0A8C1RGW2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
VFLCLYKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNS
VYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKTKFLNRLQA
LAKGEKKACSGKCKKGSCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSDAESSAEEEKS
HGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTKSMLRGRGG
CYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWSWKMDPAEKIIQEAVENH
KNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTN
AQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYR
LTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQ
LANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSA
MDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A1D2J773|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paracoccidioides brasiliensis|TrEMBL
MTGIVLGISPPGLLSLWHKYRIPILFLAPVVLAVVRLLPKYPTSDPPHSSGSSPLPSSKE
TINSGDVQERELLLSKTEPPLATLTKHDPSPSSSPDSDKRTKRRLNGPKRVHGTKPLKND
VNRLSGHARLPRDIVIQPLVFYASLTGSTEAYAKSFCDRLQGAAQSSRNNGNGTFLAPKL
HDLSYIEFDDYFIAAPNPTDSAPNTKFFYCILIPTYNIDTMINTFLDHLNETHNDFRINT
SSLSGLIGYSVFGFGDGEGWPTEEAGFCSQAKEVDRWMAKLTGKKRAYPLGLADVKDENL
QIILSDWCDGLSDVLSDLVALGGGLGEGVPGSGDPIESDEEEDIDGEPAENKTNGGNRLK
KDQEQRPIVDMEDIKFTISDEKTSADSQLLPIDFTTQSGTQSFKPAAQLEMVPTSSPTHA
ALTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVF
CWRHGTNPVGTTWRWRADPPDLIFDGVKAGHYKKIKMLRGVPGVRAERFAEAMRIRHCAL
SLVGEPIFYPHINKFLELLHGEQISSFLVCNAQHPDQLATLDRVTQLYVSIDASNRESLR
KIDRPLHRDFWERFQRCIAILREKRYFQRTVYRLTLVKGFNVDEEVVGYADLVEKGLPCF
VEVKGVTFCGTSTSARAGLTMKNVPFYEEVVSFVVALNAELSRRGLGYGIAAEHSHSCCI
LLASNRFFVNDRWHTRIDYDKFFILLQREKSDGIQFRPEDYMRETEGWALWGNGGFDPND
TRVYTRGKNKAKQNATIEESLAQGASVNG
>A0A2T4CGD4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoderma longibrachiatum ATCC 18648|TrEMBL
MDAAYRLQLEALVADLVDVWHAYRTPIILSSLILLAGLRIFLHTTEDREPLVALPKIYNE
PQQPQAREKTSSEAQPVAETEKKSSGPRRIKGGVTRKSSQEDKIAPAEHDRPAKVLVFFS
SVTTKTEKIAHDYIKALEAYLDNQAKETDAKFLKPELLDLTEVDFEDYFVSPPKSAEGAA
YFYLFLLPSYNIDTINDTFLQHLQETHHDFRIDTAPLSSLVGYSVFGFGDKEGWPNEDEG
FCFQAKELDKWMSKLTGRKRAFPVGMGDMKSDHAERFAEWTSGVQEVIAQASQTGFLGEG
VPGSGDAVESDDEEAEGDDGEVVFDDEEPSNGKESDGSRPLDDVEDLGKMIRPNKDGSDG
PRKAPLAVDFTTYPSATKRKGQAPVIKEMVAKDSPTYNALTKQGYSIVGSHSGVKICRWT
KSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPEM
IFDGVKENHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYPYINEFLAMLHSE
RISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLKKIDRPLHRDFWERFLRCLDILR
EKRFRHRTVYRLTLVKGFNVEDEVEGYAQLIERGLPCFVEVKGVTYCGTSTSSNAGLSMS
NVPFYWEVCEFVKALDRRLREKGLGYGIAAEHAHSCCVLLASDRFNVDGKWHTHIDYQRF
FELLEERGPDGDWTPEDYMGPPTPEWALWGNGGFDPRDERVDRKGRKMEAVVAREAPE
>A0A3N2Q1I9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sodiomyces alkalinus F11|TrEMBL
MSGIWNYWALLPFLNDLHDAWQQVRVPVLLSVAFSLVLLRIYLRAKGGTPELKTLPRKFA
DNPATGKESLVRDAKIKPQTETTAEKETKPVKSQGPKRVKGGIVKRRSSDGERNDQGPRQ
IQPLVFFSSITANTPKISHEFAQRLHADLHPVSSSTGCTFLSPEVLDLAEIDLDDYFVAP
PKAKEGIELLYLFLFPSYNIDTINDTFLEHLKETHHDFRIDTAPLSSLLGYSVFGFGDRE
GWPTEQEGFCFQAKELDKWMAKLTGRKRAAPIGMGDTKRDYARRLAEWSEGVVDILQQLA
KTGSLGEGLPGSGAPVESDEEDIEDVDDEDDGEVQVDDSRTKPQKPKKVKNVEDVEDLGR
IMKESRSDLDSSANRGAPIAVDFTTYDKSTTSKGRAAAQPTIKEMVPKNSPTYASLTKQG
YTIVGSHSGVKICRWTKSALRGRGSCYKFSFYGIASHQCMETTPSLSCSNKCVFCWRHGT
NPVGTKWRWVVDPPEAIFEGVKAGHYQKIKMLRGMAGVRADRYAEALRIRHCALSLVGEP
IFYPHINEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNRESLRRIDRPL
HRDFWERFLRCLDILRERRQKQRTVFRLTLVKGFNVDDEVEGYANLVERGLPCFVEIKGV
TYCGTATAANAGLSMSNVPWYWEVCDFVKALEKRLAEKGLRYGIAAEHAHSCCVLLASER
FRVDGKWHTLIDYKRFFELLEERGPDGDWRAEDYMGPATPEWATWGNGGFDPRDDRVDRK
GRKIATT
>A0A7D5R515|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosotenuis sp. DW1|TrEMBL
MSCSGEIVEPENDIIQIKSSIQEQLKKAKYGVSDHSTVELCHWTKKSFKNEGSCYKHKFY
GISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSLEMDASKVASPEEILARLMKEREKLIM
GHYGDPKSDTKKLDESLLPSHYAISLSGEPTMYPKLPDLIKYLKSLKATKSVFLVTNGQE
PDMLQRLSDEDALPTQLYLSTNAADYKSFIEINKPRYKDSWERWNRSLEMLANLDTRTVL
RVTLIRNYNNSDEMIPAFAEMVKRSDAHFIEIKSYMHIGRSTNRLDRSDMLEYGEVMHFS
SELAKKSQIYSVMDDSQVSRIVVLQNNQRFIDRWISAYSCT
>A0A662FKG4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MVSDALRRDFEKQQYRVVGNHSVVKVCEWTKKSLRGGKLCYKNTFYGIHSWQCVEMSPTW
FCDHRCVFCWRDTKYSWPSWSGPVDDPKLIVDGCIREWKKLLFGFGGFDKTDKKRYQEAM
SPKHFAISLTGEPTFYPRLPELIDEIHSRGMTSFLVTNGTVPDMIEKLLTHQPTQIYVSI
VGPDKETYVKVADPLPKDSWNRLMKTLRLLKNFKRSVLRLTLVKGLNMFDPEGYASLVRL
ADPDWVELKAYMFIGHSRERLEIENMPLHKDIKEFAARLAEILGWKIVSERAESRVVLLA
KNDSEDRFLSF
>A0A842UV25|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon|TrEMBL
MAGIPSDWRKILEKQQYEFAGEHTAVKICTWTKKSLRDEDVCYKERFYGIESHRCCQMSP
SIGYCQNRCMFCWRPTEYTMSFPMRGKVDDPKKLVRECIEAQRKQLSGFGGNKMVNKKKF
REAQDPNHLAISLAGEPLMYPKLNQLIRETHKQGMTTFVVTNALVPERLKEIEPPTQLYI
SLDAPDEELFSKIDRSRLKDAWKRLNKSLDIMKNLKNKTRTCIRITCINGLNMVKPEKYA
ELIRKADPLFVEVKAYMWVGFSQYRLEISNMPMHDEVRHFAEEIGKRCGYKVVDEKEESR
VVLLMEKDFRGRKMKF
>A0A091Q0J9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haliaeetus albicilla|TrEMBL
LDVSMDTWNFYTCLVSLWLHRFYIYSAVAFGISIWIVIQFTTTKTKKKGEKSNGNPASFE
GIEDKVVNGYATLQAKEVYVAGVKIFYGSQTGTAKRFAKGLAEAVIALNLPVEVISMGDY
DPDDCLSEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAVNDFRFGKTYLKGLRYAV
FGLGNSVYVDHYNTVGRNIDKWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKF
LSQLQALCRGEKKPCSGKCKKGKCKSLGKQSKESSDHEHGASEYENTEAEELFETSSDEE
ADGEEAGGTNSVIDVEDLGSIMSHMKKAKVRNCCYRDTGTSLTHKNAGRKEEGEKREMIT
LALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACA
NKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKADRFEEAMTV
KHCALSLVGEPIMYPEINQFVKLLHQHSISSFLVTNAQFPDEIRNLGPVTQLYVSVDAST
KESLKRIDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGEP
DFIEVKGVTYCGESSASNLTMANVPWHEEVVRFVQELADLIPDYEIACEHEHSNCLLIAH
KKVRL
>A0A0H4T7M0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|uncultured euryarchaeote Rifle_16ft_4_minimus_37664|TrEMBL
MDPERKEVLERQGYRIVGEHSGVKLCHWTKASLSKGVGCYKQTFYGIESHRCLQMTPTVD
ACNLGCMFCWRTQEWGSDGLLEADDPSSIVDGSLEAQRALLSGYKGHPGVTRERFLEAWH
PTNVAISLTGEPTLYRRLGEMIDDFKRRGMSTFLVTNGTTPAVLRRMREEGRLPTQLYVT
VAAPNEDVYRRLMAPKSDHEWAKLLETLALLPEIPTRTVIRHTLVEGWNLGWEDEYAALD
RVAKPMSIECKGYSFVGESRLRLREENMPSHASIRTFARALADRLGYAVAAEREDSRVVL
LTPDGELHPVSS
>A0A6J2QW60|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cottoperca gobio|TrEMBL
MLSFFVIIMLCISGVSTSDAKGSQDAHSPSESYLMSIWHNRLYLYSAAALVFGIWFSLKV
ALKKKSFSKEIGPWVYKAVKSNDSSDGDTVVHVSGVKIFYGSQTGTAKGFAKELSEEVKT
LGIPAEVIDFKDYDADDQLADECTKKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFR
YGNTYLKGLRYAVFGLGDSVYAGHYNTVGTNFDKWLWMLSGMRIMTRGEGDCNVVKSRNG
SIQADFLAWKVKFLIRLQALAKGDKKSCTGNCKTGGSCKDEKKEEEDEEEAEAALQNNSS
EEDLMESSSDEESGLQDETQSGSVVDMEDLGNIMNSAKKAKSKQEGREGGLLVKPSKLNG
VKKMEDEGERREMITPALRKALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGI
ESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILLDALENHQSMIRQFRG
VPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPKEIGS
LVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLGSLRALGEKRQRTVYRLTLVKAWNV
EEMQAYSELISLGQPDFIEVKGVTYCGESAASTLTMANVPWHQEVVAFVQQLADMLPQYE
IACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQGFSALDYMAKTPN
WALFGANEQGFDPTDTRFQRRNKTKDISGC
>H3ZLN1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)|TrEMBL
MDVKPNMPEEIANLFKKQHYALIGHHSSVKLCHWLKESIKHDRFCYKQKFYGIQSHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPQPWDEPSYIVEKSIEAQRKLLSGYWGIKDQIN
VKKLEEAMEPKHAAISLSGEPMLYPMIGDLVEEFHRRGFTTFIVTNGTEPEVLEKMIKEN
KLPTQLYVSLTAPDEETYQRVNVPMIPDGWERINRTLELMRDLPIRTVIRLTLVKGENMH
NPEGYAKLIMKAKPMFLEAKAYMFVGFSRNRLTINNMPSHGDIKAFAEELVKYLPGYHIE
DEYPPSRVVLIMRDDISKKDRFIKH
>A0A0D2DDM8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala xenobiotica|TrEMBL
MSRNGRKTMDLGEGGAAPVVLADWLDRLLTSWHNHRVVIWTAFGLAFVFVWLQRRRIRTL
QTRGSSPGLEKANWLEGKDKEQLATTNKKSPSSTERQPTAVASRKPRSSTPRVVAGRKPN
PRGGLGVPRQPEPACIQPLVFFTSLTGTTERLSKTVLTRLESLSALQPAVLKPQVHDLSY
IDLDDFFISGPKTSDSRPDVRYVYVLLIPSYDIDTILNTFLAHLDETHNDFRIDTASLSA
LAGYAVFGVGDKQGWPTEEMGFCSQAVEVDKWMAKLTGRKRAYPLGLGDVKNNVAQALQD
WVSGVCAMLEELSLNGGLGEGVSGSGDAVESADEEELEDDEIDFPDSGRNKRRKLASAAD
VEDVGGKGAPMAVDFTTYSAPSTAPVLLKAMVPQESPTHAALTKQGYTIVGSHSGVKICR
WTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDDP
QMIFDGAKAGHYKKIKMMRGVPGVRSERFEEAMRIRHCALSLVGEPIFYPRINEFVGLLH
NEHISSFLVCNAQHPQQLRDLRRVTQLYVSIDASNRDSLRRIDRPLHRDFWERFQSCLDI
LREKRFVQRTVYRLTLVKGFNIEDEVEGYAGLVEKGLPCFIEIKAATYCGTSTSTNVGLT
MQNVPFYAEVVTFVEALNKALAKRGLDYGIAAEHAHSCCVLLASKRFFINGKWHTIIDYD
KFFKLLDEGVDFAPEDYCMETPEWALWGNGGFDPRDERVDRKGRPKATKEKEVAVKMADE
SGKLEF
>A0A7C1BYC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobia archaeon|TrEMBL
MRKTLEKQGYHFVGPHKHSAVKTCLWLWKAMRREGEGNCYKGKFYGIAAHRCVQMTPSIF
CNQRCVHCWRPLEAFNIRKEEEVVWDSPEEIVDGCLKEQQRLISGFKGSHKTDKNTFAEA
QTPKHAAISLIGEPTLYPQLAELVQEFHSRGMTTFVVTNGTNPEVVRKISPSQLYLSLNA
PNEEIYKKVAHPDYNYWSRVKESLEELGRKGKEKEREKGEAGEEGEAGEEAEAGEEAEAG
EEAEEREEEGKRRTRTVVRITCVEGLNIQNPEGYAELLKIAKPDFVEVKAFMHIGYSRRR
LPREAMPSHSRVKAFASEIAEQLGSGSGADYKVVNESEVSRVVLVSKK
>A0A5D2W6S2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gossypium mustelinum|TrEMBL
MTPSSLSTRLTLFALLSATTFYFLYKSRRRCLKPLKHLPLNPNPRPGKLFFLTQTGTSKA
LAQRLLDLLSSKNNIPFDLVDPHTYEPEDLPKESLIIIIASTWEDGNPPQNSKFFVNWLA
DISTDFRAGNLLLSDCKFAVFGVGSRLYGDTFNAVARDLGKRLRGLGATEMVPVGEGDVD
GGELESVFEGWSEKVVTVLKGGLVMENENGIVYESDVESLESDDDDDGEGGGEDIVDLED
IAGKGPSRKKSVNVAETNGKLDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNT
AIDLHTKMIKQTKGVPGVTQERLMEGLSPRHCALSLVGEPIMYPEINALVDELHRRRIST
FLVTNAQFPEKIKMLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKSLKEKHQ
RTVYRLTLVKGWNTEDVDAYSKLFVLGKPDFVEIKGVTYCGSSATSKLTMENVPWHSDVR
AFSEALALKSAGEYEVACEHAHSCCVLLAKTEKFKVNGQWHTWIDYEKFHDLVALGRPFD
SEDYMALTPSWAVYGAEEGGFDPDQSRYKKERHHKSKH
>A0A8D2IZU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Varanus komodoensis|TrEMBL
MNLPAEVIDMGGYDPEDCLVDEARSKSVCVFLVATYTEGKPTENAAWFCKWLEEAACDFR
VGQTYLKGLRYAAFGLGNSSYADHYNTVGRNVDKWLWQLGARRVLSCGQGDANVAASRHG
SLEADFEAWKHRLLTRLRALCKAGKAACGGGCKKGRCAPKDEKRRRTAERELGTQEQEEE
PCETTSEEDSGDEAGRRARQVVDVEDLGHMVGHMRRAQRERELDREAAGVAGSQQSAGEG
EKREMLTPALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIQSHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEALENHQNLIRQFRGVPGVRTDR
LAEGLEASHCALSLVGEPIMYPQINQFLRLLHQRKISSFLVTNAQFPEEIRSLVPVTQLY
VSVDASTPDSLRRIDRPLFKDFWARFLGSLQALAEKRQRTVYRLTLVKAWNVDELRAYAA
LVSLGRPDFIEVKGVTYCGESSASSLTMANVPWHEEVCRFVQELADLLPEYEIACEHKHS
NCLLIAHKKFKIGGKWHTWIDYERFQDLVYRYEQSGGAETFTSEDYLAPTPPWAVFGAQE
KGFDPTDTRFRRKNKTKDISGC
>A0A7J6SB75|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus olseni|TrEMBL
MLAGGFYHALLSKHYSGPSRTVKVVYSSRTGTSKAAAGRLKDTLESDKIRVILLPIEQYS
YEELCEESYLVLLLSTDTDGTPLPGAKDFTEQLRDAVYDFRVDKNLLEKCKVAVIGFGSE
EYPAKHYCKVAKNCDDWLAKLGAQRVSPLLCISDTRDVEKQVGRCIDLIKKAYARLDVEP
TDQRTADLEDDVESVGSEESTSDTEDGDVEDASGACGSSNKEMVTKKHRAALTREGYRLV
GSHSAVKLCRWTKHQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPVG
RSWTWAQDPPEEIVDGWLGNHAGMIKELRGVPGVTPERFEQAKKVRHCALSLVGEPIIYP
QINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAKDMKAIDRPLFEDF
WDRFIDSLTALKHKKQRTVYRMTLVKGYNISTAAEYAELLHLGNPHFLEIKAVTFCGKGD
GSAQMTMENVPWFEEVVEFAQMMIESSPWVKERYEIACTHRHSCTVLIAQKSFKVDGVWH
TWIDYDKFTQLALEYSKTGKPFAVEDYWAPTPAWAVYGAEEEGFDPEMKRHYRNGKTPEL
GKQIRAKQLREEQERSSKYNVTSGLGEDVVEFFD
>A0A3L6JKJ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thorarchaeota archaeon (strain OWC)|TrEMBL
MPMELRAKLERQGYHLFGKRGAYKACQWQKKSLLHGDACYKEKFYGIESHRCVQMTPVVD
KCTQSCRFCWRVTPEDISVSWDQVHVSTDDVVPVDELMNAVLMANIRSLGGYNPDAGADV
PMKKYLEAREPRHVAISLAGEPTLYPYISELIDEISDRNMTSFLVTNGTRPDILRKMSEP
TQLYVTLAAPNEKTYRRLCQPGVRGGWQNVLESQESLQSLDCRTVNRLTMVAGQNMQDPR
AYSELIMRGEPDFVEVKGYMFLGSSRHRLGRNNAPSHREIRAFSKKLTDLTGYYLVDEQT
ESRVVLLSQNRHIKKLQLD
>A0A662Y158|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nothophytophthora sp. Chile5|TrEMBL
MYTCPTAFWQNRNSGGVALRLEAKRLTREDAGSEMAFLSPAASASASVSVLLVATVTIGV
LYYLSMQSSASASSGTSGSPKRKARAKQQQQQQQANKGKSKPAAIKPPPAMPVRILYGTQ
TGASKSTWLSMAVVVRFEKTLFALNIAGFHFQTSVVSMKDYDQDNLEHEAIVVAVLSTWT
HGVPPEDARVFCNWIADMTQDFRVSKSWLAGVPHAVFGLGNAEYDEDYGTAAKNLDRDLT
ELGSPALVALGLGDDNVDQFQQFDVWMDNVVAAMCEYSSERAVAASGKAGDGSETEQASK
KAWLSQKEFRRQKKAKKAQQDVVNGVAVELNEEDLMNEQFLTDAFSDDEEEQNGQDADDD
GGMVDVEDLGKSMKESEAASKSREMVTPMQRKALTKEGYKIIGTHSAVKLCRWTKHQLRG
RGGCYKHAFYGITSYQCMETTPSLACANKCVFCWRHHKNPVGRVWRWKTDDAETLVKGSI
ERHQSMIKELKGLPGLIPQRWDEAFTVRHCALSLVGEAIMYPQINEFCKQLHERHISSFL
VTNAQFPEKIAALDPITQLYVSVDAATKESLRAVDRPLFKDFWERFLACLEELKRKGQRT
VYRLTLVKSYNMEELDNYAELIDIGQPDFIEVKAVTYCGKSDGSDLTMKNVPWHEEVRGF
CSALCDRVSGDYALASEHAHSNCVLLAKKKFCRDGVWHTWIDYDRFHELVAKFYEDGSPF
TADDYTAPTPAWALYDSKEQGFDPVETRFRRTKDGKVVEFEYQATESGCG
>A0A8C6WMR1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neogobius melanostomus|TrEMBL
PQKSHGPVLSYITSIWHNRLFLYSAAALIFGIWFSVKVLQKVNSLCSLLFVQGFAKELLD
EVEASGFPCEIIDMKDYDPDDQLADEGTNKTVCVFLLATYTDGQPTENAEWFCKWLEEAS
TDFRYGKTYLKGLKYAVFGLGNSVYTGHYNTVGKNVDKWLWMLSAARIMTRGEGDCNVVN
SKHGNIQADFKAWKMKFMNRLKKLAKGDKKSCNGKCKSGGSCKNKTKHEHGHEERSEHED
LFESSSDEEESGLQDEKKGPVVDMEDLGIIMNGVKKAKSKDGEQMVKLSKVNGVKMAEDE
EGRREMITPALRDALSKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCME
TTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIREFKGVPGVKPE
RYEEGLAVKHCALSLVGEPIMYPEINVFLRLLHSNRISSFLVTNAQFPREIRNLVPVTQL
YVSVDASTKDTLKKIDRPLFKDFWPRFLDCLKALGEKKQRTVYRLTLVKAWNVEEMLAYA
DLIAMGQPDFIEVKGVTYCGDSTASSLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEH
SNCLLIAHTKFNIDGEWWTWIDYERFQELVQAYEDSGGEQTFSSLDYMAKTPTWALFGAE
EQGFDPTDTRFQRRNKAKNISGC
>A0A2R7Y371|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aigarchaeota archaeon NZ13_MG1|TrEMBL
MSTIPVYGRSRDELKALERFKKAGYRIVGRHSAVKVCHWTKTALKGGKLCYKRWYGIRSH
RCVQMTPALQYCNMMCIFCWRFHSVNRASPYSGEWDEPRSILEGCIAAQRELLSGFKGNP
KVTMERFREAMEPRHVAISLDGEPTLYPYLSDLIKEAKLRGMTTFLVTNGTMPDRLRELE
VLPTNLYISLYGPDEATHKQVTRPLIAESWQRVLRSLELMSTLSCRRVVRLTLVKGYTMK
EAEKYAELIKIATPEFVECKAYMHVGESQKRLPRDAMPSMDEVVAFAEALRKFLNYALVT
EDSDSRVVLLAKPDVELSGIEAL
>A0A421ED83|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloarcula sp. Atlit-47R|TrEMBL
MSDADGGPKQVSDPAYHSENHTAAQTCGWTKNALRGEGKCYKYIFYGIESHRCIQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASVELQRKLLSGFGGNDEVPREVFEQA
MEPRHVAISLDGEPTLYPHLPELIEEFHDRDITTFLVSNGTNTEMLERCDPTQLYVSVDA
ADRRTFDSTVQAMEDDAWDSLIDTLDVLAEKGDTRTVIRTTLVKGHNMHHPEWYAAMCDR
ADADFVEMKAYMHVGHSRGRLDRDSMPDHSEVREFTREMSEYLPDHDVLKEVEDSRVAML
AEDENTWVPKLEKSSEFWERDALVEY
>A0A662MA89|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MDESLRRMFEKQGYAIVGNHSAVKTCHWLKESIMRGRVCYKQSFFGIMSHRCLQMTPVAN
MCNHACRYCWRYQGSDDIQVEWDDPAAIVEGTIEAQRRLVSGFKGDERCDLRVWKEAREP
NQVAISLTGEPTMYPHLGELIGEYHSRGFTTFLVTNGTFPDVLERLDPLPTQLYISIDAP
NESIYRRLCRPKISDGWERLMRTLELLPSLDTRTVARHTLVKGENLGFERQYAELDAIAD
PDFIEPKGYVFVGYSRERMSMDNMPSMDDIRSFAGRMSELTGYGIAGESPPSRVVLLKKD
GVTLRIDETPANET
>A0A7J4PC03|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MREEVRALLKKQHYALVGNHSGVKLCHWLKKSLLSGRLCYKHDFYGITSHRCLQFSPTIN
HCTQKCVFCWRFQGYTESKVENPEDPKTLLDQAIEAQKKLLTGFKGNEKCDLRRWEEANK
PQHLACSLVGEPTLYPYLSELFEECHRRGMTTFLVTNGTNPKAIKELDTLPSQLYVTVAA
PNKEIYRNLCRPLISDGWERLMQTLELLPSLNTRTVIRHTLVDGWNLDGWVDAYVRLDSK
ADPLFIEPKGYVFVGGSRQRLSINEMPPHQKIREFGSRMAQKIGYELIMEREDSRVVLLT
KDKSRMKLVQ
>A0A7C0WZC4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MVRVKISPEQLERYKKAGYRVIGKYLHSGVEICRWTKAALKGERFCYKKWYGVASHRCVQ
MTPTLDFCNFSCIFCWRMFSPDRFKSAMEWDDPKTIVDAAVRAQRELLAGYKGHPKTTTE
RFLEAMHPVHFAISLDGEPTLYPHIVELINEVKKRGWTAFLVTNGTVPHRLKEMLRKNVV
PTNLYISVYATNPEDYKRITNSFIPNPMDMVIKSLKLMPEFEKKRCRTVFRMTLVKGLNL
KDPQGYSKLIKLANPMFVELKGYTWAGESTKRLPREAMPTLEELIEFAKAIEKETGYHIK
EIDEKSRVVMLVRDEETWLKNLEWIKEQNKKIKEYDEKWKEKLKGKDLKHLLKHKLLE
>A0A8J8J8V8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 9N3|TrEMBL
MAIVVKANPNMPEEIALLFRKQHYELVGRHSGVKLCHWLKESLTKGRFCYKQKFYGIASH
RCLQMTPVLAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGNP
KVPKEKFEEAWNPKHAAISLSGEPMLYLYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKIKETLKLMRDAETRTVIRLTLVKGE
NMHSPEKYAELIKIANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDGRGRGLTGRFISD
>A0A0X8HTU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Eremothecium sinecaudum|TrEMBL
MYDEWLKLSRLPNRVVVVGVAATYFFNGGRLSIAVAFVLIYMMAHREMMKAGIDEVTKVK
TTGEKSSCCSGKSGGCGSTNAVDGSKKKTKGCCGGACKSKGGKSVEIKKNNVDESSYPIA
IDFTNAFKAPGGGSAKVKKVPKLISGQKSVKKADGLVKQALTISKEKLLASQVYVFYSSL
QGMASRSARRVVEILKKLEKLEKEPLLMNLDEIDDLNSYFVDVPDEAALYIFVVPSYDSD
SPLDYFLETMQENFNDFRIDKYPLSKLVGYTVLGVGDSESWPEKFCYQAKDVDEWIAKLG
GRRIYPLGRVCVKFGGDPKVEEWAELLAETLKDDEPILYEYDESVDDKENQDIDAADDSL
VDLEDIGGSGDVKQSSELKKMVAKDGPTYKNLVKQGYAIVGSHSGVKICRWTKSDLRGRG
SCYKHSLFNIVSSRCMELTTSLACSSKCVFCWRHGTNPVAKNWRWEVDEPDYILENALQA
HYSKIKQMRGVPNVVAERFALAFKVAHCALSLVGEPIMYPYINRFVKLLHEKHISSFLVC
NAQHPEQLENLGKVTQLYISIDAPTKQELKKIDRPLFSDFWERMLRCLEILRTTQSHQRT
VFRLTLLKGFNMADASAYVDLVMKARPCFIEVKGATFCGSSDGNGNPLTMQNIPFNEECV
KFVKCLTSELQKRYLNYDVAAEHAHSNTILIADTKFKKEDGWYTHIDFERFFELLKSGEP
FTNTDYMAKTPEWALFGNGGFAPGNVRFYRKKKNANKEVTVA
>S2E4T4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosarchaeum limnium BG20|TrEMBL
MSCSGEIVDEERLIQIKPGISQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFYG
ISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMDPEKVAEPKEILTKLMAERKKLING
YYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEETKSIFLVTNGQEP
DMIQRLQDEDALPTQLYLSTNAADYESFLKINKPRYDDSWQRWNRTLEMLKKLDTRTVLR
ITLIRNYNDQEEMIPAFAAMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVRKFSE
SVAEHSQIFSVMDESLVSRIVILQNNQRTIDRWIPAYANTN
>C7P2L0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halomicrobium mukohataei (strain ATCC 700874 / DSM 12286 / JCM 9738 / NCIMB 13541)|TrEMBL
MSESDGPKQVDDPDYHSENHTAAQTCGWTANALRGEGKCYKYIFYGIESHRCIQMTPVVK
CNERCVFCWRDHAGHAYELGDVQWDDPSAVADASLELQKRLLSGFGGNEKVPRERFEEAM
EPRHVAISLDGEPSLYPYLPELIEEFHDRDITTFLVSNGTNPDVLDRCDPTQLYVSVDAP
DRKTFDDTVKAVEDSAWDSLIDTLDVLADKDDTRTVIRTTLVKGHNMHHPAWYAAMCQRA
DADYVEMKAYMHVGHSRGRLDRESMPSHDEVRAFTEEVGGFLPEHDTMKEVEESHVTLLA
REDETWVPKLEKSSEFWERDPVVSY
>A0A1I6RV15|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halostagnicola kamekurae|TrEMBL
MSDSDETLQVSDPDYHSENHTAAQTCGWTANALRGEGKCYKNIYYGIESHRCIQMTPVVR
CNERCVFCWRDHAGHAYELDGVEWDDPEAVVDASISLQKKLLSGFGGNEKVPDEVFEQAM
EPRHVAISLDGEPSLYPYLPELIEAFHDREITTFLVSNGTRPEVIRECDPTQLYISVDAP
ERHTFDQVVQAMEDDAWEKLLETMDVLAGKDETRTVLRTTLIDGENMHSPDLYAAYYQRA
DPDFIELKAYMHVGHSRGRLDRDSMPDHEEIVAFAEDVKEHMPEFTECKGVPASNVALLS
KTKDTWVPKLKKDSEFWADDPLASD
>A0A2H9N0G2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon CG15_BIG_FIL_POST_REV_8_21_14_020_37_27|TrEMBL
MDENLKKLLEKQQYRFSGNHSVVKICRWTKKSLVEGKVCYKEKWYPPVKSHRCMQMSPSL
VCNHRCLFCWRLHSGDRGFSWKESFEGLVLDEPKDILEKCIEQRKSLLTGFKGFERVDKR
KWEEALKPNMMAISLTGEPTMYPKLDELIQEAKRMNIISFLVTNGTLPDRLQSLNTKPFQ
LYVTLPAPNKETYKKLCQPSTPKLWDKIMETLELIDSFDCRKVIRLTLVKGLNMVEPEEY
AKLIEKANPDFVEAKGYVHVGESQKRLPMDAMPYHEDIIEFSKEIEKHSSFRIKDVFKPS
RVVLLKK
>A0A6S6WA64|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrenophora teres f. teres|TrEMBL
MVFLQYAEQLPTELLLIWREHRLEILLSALVVATIARLVIYSRDRKREKVSQSPVPLSPV
EKQTVELKPEWLPEYTTTLSPPLLNVDNHAEDDAAAVRIVSKAKKGPKTVKGRKIQKKNI
VPVSTFDHKADKIKLLVFFQSLSGTTERYAAQFAKTLTEWTAGCDQSASFLEPQTLDISY
IEHDDYFISPPKADANVKYFYIILVPTYNIDTVLDIFIEGLQETHNDFRIDTAPLSGLLG
YSVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMADVKTEAEERLQEWRI
GIQEALIEIAEGRGLGEGVPGSGDPAESDEEDVEDLDDGTGQSTRVDDVEDLGSMVNSSS
APIPVDFTTYKKAAPKSKQVQAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSA
LRGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDLIFD
GITAAHYKKIKMMKGVPGVRAERFSEAMRIQHCALSLVGEPIFYPHINDLLSIMHNHRIS
TFLVCNAQHPAQLASLVPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRR
FEQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVP
FYEEVAAFVTELEKELNTRGLQYGIGAEHAHSCCVLLADKTRFQKNGRWATRIDFERFFD
LWEGKVKGTRVEGGEVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKTEEKI
EGEGEGESKVERAKALEF
>A0A2C6K8R4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cystoisospora suis|TrEMBL
MWAPQNSHPLLFSVLAKYARSHTFAPSSSSASVSPTSSSHNTSRKIPLFPYFRFHSLPSN
FSYSYGLPESSEEKKTSPLRTSSLENLLLSHQETSSSSSSPSSLHCQASPSTRVPPLSSL
HSSSSSSQEPSLLSRGHGGERKETKEDANDRHHEEEQHISSSLSSTKKTTLHISLPSPLS
SSSSSLTPPSRGMGETRNTSKIIPHPSTSQSLHTSGSSSSSSSTPHSSLPLPSSSSLSAK
PFPSSSYHHHHHSSSPPLPLRVVILFGSTGGTSAAVAFSLFHSLVHRLLASSSSSSSSSS
PHASSSSSSCRSVHHPRVSTPRISTSPLSRRDSDKGGETGLFSSSPKANSPSENEENSRK
PSAPQASSSSTPNGMLVNGVEEMDAEKKGGEEDTCKKKKKKSRDSSSVPSSSSSSPRNPK
QDKDLSLQSRTSRLTPRSSSSSSSSSSLPLHERLSSGRSEGARELSRLSSSRLSRHDPNG
GLDHRPEGTPSMKSHLLLRKNSKGEGGDYLHDYDKTRQKGLSTSSHGHFATSSFFSSGEE
RDTGVKGSSSSNSEGSLQGEEDSEFLHAFLSRKRDAAIRAAETASLGLRVASSYADTALK
KAKERMEEKKKKDRSERREKKGMRGRGGDKDDEREMKETEERKRSEEEEERQEDEKDEEA
SDEEDKIWFLDQVKVGHIEVYIQSMEYISFEDLLSFVEESRSIAHRFTSPSSSGVCTPHL
LLFFALSTFSHGTPPPSAEAFYQEVEESSRDFRVDRLALYDCAIAGVGCGSTDYPSSTYC
KPAKSLLALLHNSFGMRLFLSSQPLLFLSDTSADATTEMKLRKWRDGLLSQFSLFIHPET
SYSSRLSLLAHAEKSLSAPRQQQPVSNMSMFPSTSSRLTGKKKSSSLLSSSSSFSLDERS
LIEQQLDAEEATVIPGIRKQRPDDIGPGAGVGGDRRRRKTKEEEEKKRCDENDGDEKEKK
IGVGESPNEREHERIFNKKKDEEESERDIRDKETRAEEEQDNEQAGRRRNRDITVDGEKN
ATEETSSSSSSSSSSLDESSSEEEEDEEVNDGEISMVEKRHPSSQTSLLFSTCHSNVEAE
DLEDLIPNDSHPPPLSSSSLPSQPPATSQKKKATKTSSSLLKPMLSAGQAEKLRKEHYKI
VGSHSAIKLCRWTKSQLRGRGGCYKNTFYGITSSQCMELTPSLACANKCVFCWRHHKNPV
GTSWRWQVDEPDFILQEGLKSHFQTIKELK
>A0A832YQQ7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermococcus okinawensis|TrEMBL
MTTYNTPIPEEVYRILRKQRYQIKDHSAVKLCGWVKKSLLENKNCYKSKFYGIETHRCIQ
CTPSVIWCQQSCVFCWRVLPSDIGVSQLSYPEVKWKEPEEVLEDILQMHRKVVMGYKGIL
DRIGKKKFKELLHPKHVAISLSGEPTLYPYLGELINLFHRKGFSTFVVSNGILTEVIQEI
NPTQLYISLDAYDLESYKTICRGKEEYWQSILDTLDILRYKGRTCIRTTLIRDYNTNIEK
FIHLYEMADVHFIELKSYMNVGYSRKRLTLDHMLKHEEILELSRKVEELSHYKVADDSYD
SRVVLLVNEDRKIERFIK
>A0A5B7B7P0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Davidia involucrata|TrEMBL
MSSASRLTLLALLSATTFYCFYKSRRLRLLKLSSPNPNPNLTSRRAKLFFVSQTGTSKTL
AHRLFNLLTSNDLAFDVIDPKDYEPEDLHKETLVLIVASTWEDGKPPPNGGFFANWLAES
ADDFRVGSLLLTKCKFAVFGVGSRSYGATFNVVARDFSRRMRALGAVEVLPVWEGDVDGG
DLDEVFDVWSRKLIGVLQGGSLENEGYITSGDVNESGSDWSDEDDTEENGVDSGVVDLED
IAGKGPSRKSTAVIESNGKLNGEKEMVTPVIRASLEKQGYKIIGSHSGVKLCRWTKSQLR
GRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWRWKMDDPIDIVNSA
IELHTKMIRQMKGVPGVKLERLSEGLSPRHCALSLVGEPIMYPEINSLVDELHRRRISTF
LVTNAQFPEKIKMLKPVTQLYVSVDAATKESLKAIDRPLFGDFWERFVDSLKALREKQQR
TVYRLTLVKGWNTEDIDAYSSLFDIGNPDFVEIKGVTYCGSSATSKLTMENVPWHSDVKA
FSEALSRKSKGDYEVACEHVHSCCVLLAKVEKFKVNGQWFTWIDYEKFHDLVASGRPFSS
KDYMAATPFWAVYGAEEGGFDPGQSRYRKERHHKSSH
>A0A0Q2M3T5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus thioreducens|TrEMBL
MALTFKSNPNMPEEIARLFKKQHYALVGRHSSVKLCHWLKESIKKDRFCYKQKFYGIHSH
RCLQMTPVTAWCSHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQLYVSLTAPDIETYKGVNVPMIPDGWDKIKEFLRLMGSADTRTVVRLTLVKGE
NMHNPEGYAKLIKLANPMFVEAKAYMFVGFSRNRLTINNMPRHEEIRAFAEELVRHLPGY
HIEDEYEPSRVVLIMRDDVDSHGSGREGRFIGH
>A0A5M3Z1D1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus terreus|TrEMBL
MAEVSFEGGLVSFWHSYRAPLLVLFLTGFIVVRAYRNLSSKSKTPSASSIPPTPRSPSPV
NNEKPKEKAITSAAAEKSDITSPRSPSPKSTGPKRVTGKKPLKVAGRRATSEEAPLSFIQ
PIIFFASLTGSTERYAKILLEELQTAARDRADPDNRERGLLPPQIHDLSYVDFDDFFTSA
PKPPSTSPGTRYVYCMLIPSYNIDTVLNTFLSHLDETHHDFRIDTAPLSSLAGYAVFGFG
DKEGWPTEEEGFCSQAKELDRWMAKLTDRKRAYPLGFGDVKSDAETALKEWSHGLQDILG
DIVEHGSLGEGAPGSGDPLESDEEDVDDEGQTSRKRTKAQTVVDLEDIKMGADGQNAGGS
PIPVDFTTGGKSAAPSSQGTEKEMVPTTSPTYAALTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFNGV
KEGHYKKIKQLKGVPGVRAERFAEAMRIKHCALSLVGEPIFYPHINRFLDMLHSEHISSF
LVCNAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHV
QRTVFRLTLVKGFNLDDEVVGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFY
EEIQTFVLALNEELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFELLE
KEKADGTSFTPEDYMKETEEWALWGNGGFDPNDERVYSKGKKKKMALAGAGAE
>F2TMD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ajellomyces dermatitidis (strain ATCC 18188 / CBS 674.68)|TrEMBL
MAWEDLGIVARGLLTLWHRYRAPIFLLAAVIFTVVWLAPRNSQPNTPEPDSLPASQNKNQ
NQNAKSELESFSSNDQAAADLPKRHRSRSSSVDNRPKQVTQPANGPKRVRGIKPEKNGAK
HQIGGGGLPRGIVIQPLVFYASLTGATETYAKSFCDRLQKASHPLLENNGKTNILPPELH
DLSYIELDDYFITAPKPPESAPNTRFLYCILIPTYNIDTMINTFLGHLDDTHNDFRIDTS
ALSGLVGYSVFGFGDREGWPTEEEGFCSQAKAVDRWMAKLTGKKRTYPLGMVDVKGDNIQ
KVLNEWCDGLTDVMFDVMTSGGLGEGVRGSGDPVESDEEDIDDDGEDINENGVNRRNKGK
NEQIMDLEDINFGGSNSRNAFANAQPLPVDFTTQSRAQASKPASQLEMVPTSSPTYAALT
KQGYTIVGSHSGVKICRWTKSALRGRGSCYKNSFYGIKSHLCMETTPSLSCSNKCVFCWR
HGTNPVGTTWRWKVDPPDLIFDGVKAEHYKKIKMLRGVPGVRAERFAEAMSIRHCALSLV
GEPIFYPHINKFLSLLHNDRISSFLVCNAQHPDELAALHRVTQLYVSIDASNRDSLRKID
RPLHRDFWERFQRCLDILREKRYLQRTVYRLTLVKGFNVDEEAAGYADLVEKGLPCFVEV
KGVTFCGTSTSASAGLTMQNVPFYEEVVTFVVALNAELTRRGLGYGIAAEHKHSCCALLA
SNRFYVNDRWHTRIDYDKFFTLLEKEKNEGIPFRPEDYMRETEEWALWGNGGFDPKDTRV
HTRGRNKAKLNAALKEAQDASVSAKG
>A0A662SYR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Korarchaeota archaeon|TrEMBL
MPPDVRKILRKQGYQIVLRHSGVKLCYWLRRALLDGRTCYKHKFYGIRSWRCIQMSPAVI
YCPNSCLYCWRVQQGDIEGLSWSKHTPEAPEAWDDPEEIAKESIKAQRTCITGYRGVNAI
MKRVEEAMDPKHVAISLSGEPTLYPRLGELIEVYKKMGMTVFLVTNGLYPEKLLSLESEP
TQLYVTIPAPNSEVYRKLCRPSLRDYWSRLMRTVEALSSFSCPTVMRLTLVRGINMIDPE
SYAGIIAAGNPTYVEPKAYMHVGYSRLRLTFAHMPTHEDIREFSEKLAAASGYDIIDESA
DSRVVLLSRLKKPIRFT
>A0A7J9T730|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|ANME-2 cluster archaeon|TrEMBL
MSTSPKHQLLPMSTLPEHQLELFKKMGYHIVGSHGAVKPCLWSGRSIKGMGSCYKSQFYD
IRSHRCIQMTPFLGCNQSCLHCWRPVEHPVDMPAEWDSPEEIVGGCIMEQRRLMSGYGGL
DDADKVKWKESLEPKHAAISLAGEPTLYPFLPELVREFHKQGLTTFVVTNGTKPDVIEII
RPSQLYMSLDAPDKETYIRSCAPDHQDQWEHILESLEVLCHHPCRIAIRLTLTKGLNFKD
VTGYARLIKLAEPDFVEVKAYMHLGYSRKRLKRDAMPGHEEILEFTSELGRELGYHMADH
VELSRVALLSKNEKVTPVTL
>A0A7C4CP30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MSLIPETLIEALKKHRYHIVGKHSAVKRCRWLYEALVHGRPCYKQKFYGIKSHQCIQMTP
ALFYCTQRCLFCWRAQSGDLQITWEETKLPLWDSPEEIVEGSIKAQLAILSGYKGNPKAD
PQKFKEALRPRHAAISLTGEPTLYEPIGELIQAFHKRGFTTFLVSNGTTPSTLAKLSHEP
SQLYVSLCAPNKEIHRKVCRPIIADAWEKLNETLELLQSFKCPTVIRITLVRSLNMGNIE
EYARLIGKANPTYVEPKAYMHVGFSRLRLGYESMPSHSEIREFASKLAEATGYKVIDESE
DSRVVLLSKLEKPLKFSSG
>A0A285GF65|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanohalophilus euhalobius|TrEMBL
MASDLLPDIDTLIKKQGYRLAGSHSAVKTCLWMRRAVREEGECYKARFYGIASHRCLQMT
PTLCCNQRCLHCWRPVELDVPTPSKWDSPVEIMGSSIEGQRNLISGFGGFASRELWKQAN
EPAHVAISLSGEPTLYPYLDELIEEFRSRGVSTFVVTNGTVVEMVKRIKPSQLYMSLDAP
DRQTYLEVCSPKDPCLWDNINESLSVLKDKECRTAIRITLIKGVNMFDVKGYADLIRKAQ
PDIIEVKAYMHLGFSRNRLERDAMPDHEEVFDFANQLGYELGYEVTDQVEISRVVMLCRD
GKFIASKLPV
>A0A367IE55|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MEPKIAARLAKQSYHLVGEHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLACTYCWREPHSDALTKIDDDPYELFLQSVKAHRRLLTGFGGHPSVPREKWLDAQDP
KHVAISLNGEPTLYSRLGEFLDICHQHGVSTFLVTNGSLPKVIEKLDTLPTQLYVSVDAP
NKEIFDRICKPKFDQAAFEKLEQTLELLPSLDTRTVCRHTLIKGESLGHWKDYARLDNIA
DPDFIEAKGYIYVGNSQSNHTIENMPSHDEVMDFSRNLAPLVGREVLSDRRESRVALIGK
EMIPVTLPTKIRDLPKDLGIAKPQKFTLPQL
>U3EYN0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Callithrix jacchus|TrEMBL
MDPSMDTWDLSSPLISLWINRFYIYLGFAFSISLWICVQIVIKKQDRNIQENSFPKTTQD
LMRNGYVSLQKKDIFVPGVKIFYGSQTGTAKGFATVLAEAVVSLDLPVAIINLKEYDPDD
CLIEEVTGKHVCVFLVATYTDGRPTESAEWFCSWLEDASRDFRFGKTYLKGMRYAVFGLG
NSAYASHFNKVGKNVDKWLWMLGAHRVVSRGEGDCDVVKSKHGSIEADFRAWKAMFISQL
QALQKGERKKSCGGHCKKGKCKSQQHGSEEREEGSLEQDELHHRDTEEEEPSEDSSEEEF
GGEDQQSVNSIVDVEDLGKIMDHMKKEKREKEQQEAKTSLLVNMGRNEDGEGRAMITPAL
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTAWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMAVKHC
ALSLVGEPIMYPEINSFLKLLHQRRISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKES
LKKIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVLELVDLIPDYEIACEHEHSNCLLIAHKKF
KIGSEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
QRKNKSKAISGC
>A0A6B0DL17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEEALRLVLKKQGYMLTGENSAVKLCHWFRESLLHNRPCYKETFYGIRTHRCIQMTPALN
QCTQNCLFCWRFQGFTETYLKEVDDPIQIVEGSIEAQKKLISGYGGNPEADQQKLREAYH
PKHVAISLTGEPTLYPRLGELIEEYHKRGITTFLVTNGTMPEVLEKLDPLPTQLYVTVAA
PNEEIYKKLLVPMISRGWERLKKTLEILPSLNTRKVIRHTLLKNWNMEYVEEYAKLDLLA
EPHFIEPKGYVYVGYSRERVTKESMPSHEEIREFSKRLSDLTGYFYSDEREDSRVVLLEK
EKNFPKITTL
>W5K9M1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
MSGLVDGAWSYTEGWLWMVWQSRLYVYTAAAVLLGLWLTVNMTLKKGFARELADDARAAG
FHSEVFDMKDYDPDDRLSDECTSKMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYG
KTYLKGMRYAVFGLGNSEYVGHYNTVGKNVDKWLWALSASRVLSRGEGDCNVVKSRNGSV
QADFQAWKAKFLTRLQALARGEKKACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSEELFE
SSSDSESAGEEEKAHGSVIDMEDLGNVMNHMKKAKKQSEEESQRGKLSKLNGVMKTEGEE
EAREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMET
TPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPER
FEEGLTVKHCALSLVGEPIMYPEINAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLY
VSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSE
LIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHS
NCLLLAHHKFKVEGEWWTWIDYERFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRE
RGFDPSDTRFQRKNKTKDISGC
>A0A2K3CY54|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chlamydomonas reinhardtii|TrEMBL
MDVLASLYTFGQILWAIILGAIIIAILRATKRGDDDSQSQPATSKHARKPQAHASADEAA
TSATELDAVTSSGGDGGAASSSSRSVPTAPDVAPTAAAASAAAAGAVAAAAAPVALQTPK
AANSEAAALPVAATAPPPPPPAVVAPVTAAPAASAPQPAVAPTAAAATPAVPAAPATAAP
APAAAAAVPAAATTTVAAAPPVKIVYGSTRGNCKALAEALAERLLAAAAAAPATAATSAN
ACCGGGGAAAAAASSGADAGGCCRQDTGGEAAAAPSAGDCCRQQPASSSPAPAPAPATAV
AAAAPFSSVTVIDAAAYEPEQLLTEPRDTLVVLVVSTYEGGTPPPSAGFFCSWLEDAASD
FRLGAGALGGLRTAVWGAGNSLYGAHYNAVARRLEAQLLDLGARRFRPLGLGDEDAGDLR
TQFATWAEALVAKLVPQEAAAAAAAAGGKAEEAAEEAGEGEEEEEDDAFEYEDEDDEGAG
SEVDIEDIGGAGPRRGKKGAAAAAAANGGGGGGGADGGPPEMLNALIRGSLTKQGYKIIG
SHSGVKMCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHSNPVGK
TWKWKMDPPDVIVDTALDLHCRMVREYSGVPGVKPEAVAAGLAPRHCALSLVGEPIMYPE
INALVGRLHARGLSTFLVTNAQFPDRIQQLSPVTQLYVSVDAATPASLKAVDRPLFADYW
ERFTACLTALRDKRQRTVYRLTLVKGWNMEEVADYARLVDLGRPDFIEIKGVTYCGSGGA
SSLTMANVPYHADVVAFGEAICQARGGEYGLACEHAHSCCILLARVDKFKVGGAWHTWID
YDRFQQLAAEGGDFGAEDYMLPTPPWAAFGSEAAGFDPGQVRVKKVRRHPGRTGTDSESV
AGPEDVGLEEEP
>W5K9M4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Astyanax mexicanus|TrEMBL
MSGLVDGAWSYTEGWLWMVWQSRLYVYTAAAVLLGLWLTVNMTLKKKKTVLTSSPPLSKS
EKKKEKLPEKEKVIHVEGVRIFYGSQTGTAKGFARELADDARAAGFHSEVFDMKDYDPDD
RLSDECTSKMICVFLVATYTDGKPTENAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLG
NSEYVGHYNTVGKNVDKWLWALSASRVLSRGEGDCNVVKSRNGSVQADFQAWKAKFLTRL
QALARGEKKACSGKCKKSSCKNKKEHQQEAVDEHQEKHSSEELFESSSDSESAGEEEKAH
GSVIDMEDLGNVMNHMKKAKKQSEEESQRGKLSKLNGVMKTEGEEEAREMITPALREALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHTNPVGTEWRWKMDPAEKILQEAVENHQNMIRQFRGVPGVRPERFEEGLTVKHCALSLV
GEPIMYPEINAFLRLLHQRHISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKID
RPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYSELIALGQPDFIEVKGV
TYCGESSASSLTMANVPWHEEVIHFVQQLENLLPDYEIACEHEHSNCLLLAHHKFKVEGE
WWTWIDYERFQELIQRYEDSGGAETFSALDYVAKTPSWALFGGRERGFDPSDTRFQRKNK
TKDISGC
>N4XNZ2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T)|TrEMBL
MALHDLLGQLPAEVLLIWHDHRLPILLSALVVATIARLIIYSRDRREKLPTSPVPQSPIE
KQKVELKPEWLPEYTTTLSSPDLNVDNHAEDDTGAVVAATKSKKGPKMVKGRKIPKKSVA
PALDFDHKTDKIQPLVFFQSLSGTTERYAAQFAKTITEWTTGCDQASSFLEPQTHDLSYI
EHDDYFVTPPKTNANVKYFYIILMPTYNIDTVLDIFIESLQETHNDFRIDTAPLSGLLGY
SVFGFGDKEGWPTEEEGFCSQAREVDKWMARLTGRKRAYPLGMGDVKNDAEKRLEEWRVG
VQDALVELAEGRGLGEGVPGSGDPAESEEEDVDDAEDGNGQSSRVDDVEDLGSMVNSSSS
PIPIDFTTYKKSAPKPKSAPAPKEMVPTTSPTHAALTKQGYSIIGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWVTDAPDMIFDG
ITAAHYKKIKMMKGVPGVRAERFSEAMRIRHCALSLVGEPIFYPHINQLLEIMHKNRIST
FLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILRNRRF
EQRTVFRLTLVKGFNMAEEVRGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQNVPF
YEEVAEFVTELEKELNSRGLQYGIGAEHAHSCCVLLADRTRFMRDGRWATRIDFERFFDL
NEGKVQGTRMEDGKVVGWRPEDYVGDETPEWALWGNGGFDPRDARVYRKGKGPKAEVEKS
EGQEVQTKKAALEF
>A0A497IU18|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon|TrEMBL
MLESQGYHLFGEHKHSATKRCLWLRRALRGGELCYKGKFYGIASHRCIQMTPSIHCNHEC
IHCWRPFIDKNEEIIWDMPSELIEGVLTEHRRLLSGYGGSDKTDHKRLVEAEVPKHVAIS
LIGEPTMYPYLPQLIDEFNKMGLTTFLVTNGTNPDVLKAVRPTQCYISLNAPNKALYEHV
CQPEGDYWENIMESLEIMAKANWRRTIRLTLIKGINMIDPEAYAELIRLAKPDFVEVKSY
MHLGHSRMRLDRGNMPAHHEIKEFADDLLEFMDEYCIRNEVEISRVVMIGKKESSYNCIL
EV
>A0A6J0VWM5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Odocoileus virginianus texanus|TrEMBL
MDPTLDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPRASQD
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLDLPVAVINLKDYDPDD
HLAEEVTSKNVCAFLVATYTDGQPPESAEWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYMSHFNKVGKNVDKWLWMLGARRVMTRGEGDGNVVKSKHGSIEADFTAWKAKFISRL
QALRKGEGKRCRGSCKKGKCESSRRGSEAAEPGSHAQEELHHRDAEEEEPFESSSEEESD
AEDRQSRNSVVDVEDLGRIMGHVTKEKREKEQQEGETGVTRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFK
>A0A3E2HDG8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scytalidium lignicola|TrEMBL
MAEEEPNAALPAAAADCNHSATTDSHEQKAADGPATVRFASVAQEIEPEQSLESYQSAAT
PEELSSKEQEDLRQLSKTLQGTQLQERRMSHFAFEPVSLPASRVPSNEESPSETSRFPTH
SSSGRPSPRQSPRTSAMHSPPITPLATNSREAENTSTKGAHLHKVAAEVDPSAVTPQISP
PPTSPSTVNIDNSRPGSADQISTRPTSLSTESSKERPRHHGSFVIGPSSHSVPASRDTSP
TRAAVPPIYSRPFTPSGDANDPYAAHKRPAQPRNLDVLESRFKFTALNSKHRVSPSSSSI
NLPRSSRSAATSDEKRHSSGSKIHLSHFHDESSTTIQSKGSMSELKRFLKFGGHHKSKRA
ASPASCPXGDDHGLTSKYGKFGKVLGSGAGGSVRLMKRSNDNTTFAVKEFRPRHSYESEK
EYAKKVTAEFCIGSTLHHGNIIETLDIIQEKGKWYEVMEYAPYDLFAIVMTGKMSREEVT
CCFLQILSGVTYLHSMGLAHRDLKLDNVVVNEFGIMKIIDFGSATVFQYPFEHSITPATG
IVGSDPYLAPEVYDERRYDPQPTDIWSLAIIFCCMSLRRFPWKMPRMTDNSYKLFASPPT
PGTDIRRISDVPRASKSTTDLGNPEKESESQPNPGRKSEDGGDKHHGRHANTTEDVSEKI
TEKNTEKNTKSEVIKGPWRLLRLLPRESRHIIGRMLEIDPKKRAILAEILEDPWVTGTPI
CHQEPGGKSTALKSIKSLAPLLDRVLVQRIKAETKTASGIFLPESSVKDLNEARVLAVGP
GGLDKEGKRVTCSVQPGDKVLIPQYGGSPVKVGEEEYQLFRDHEDGLQAWDSSALLKIPL
PPYRNNATTNLLGFREVLGEDGIANLAEHIFQEQFKTASSDRELGASAETTQAQSILKAT
QEFTVRPPDWLRQWQRRHANQEWGFVAIKTCCYDDEELWENFKQQFQRIVEIPFNSKEDD
PDVAEAKVKFQICWVEDPYLEGASTQALQEKYSTLKSSLPSGLSHPIFLSTSSDAIASIL
SVTSSPPSIDSKRWRPSAPYIIATAASPDPGLEEGHEERHWFQEIFKVAVEVLVDEFWLV
IDSDMMPLRKVTRRVKGVNEESGTYSLRGLRSTLVPGSCRPHHETFPSPVINNYTPEVVA
KHSSWYPFDMAYDGPSPIYPWYLSEEIVSLWHLYRILIILSTFAALIVLRTYLHFRYPKA
DLSYSLSEPNLKLPPLEEKISLELTEKTVQTAKAPRRIVGGIKKRSSSESVVGTDFKKIQ
VIIFFSSLTGTTEKAARELRESLGQELLSSNFLDPELLDLSYIDYDDYFITPPKSNGDTR
FFYLILLPTYNIDSVLDNFLEHLQETHNDFRIDTAPLSPLLGYSVFGFGDREGWPTEEEG
FCSQARDVDRWMAKLTGKKRAFPLGLGDCKSDSKKRLSEWKGGVEDVLEQIATTGSLGEG
VVGSGDPVESDDEDVSDDEGEILFGSETTSRKPKSRKKDDMNDLEDLGRSIGNSPAPKTT
ESSEPLEVDFTTFNKKSKAPAPTIVKEMVPKSSPTYASLTKQGYSIVGSHSGVKICRWTK
SALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPQMI
FDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHNEH
ISSFLVCNAQHPDQLAALKQVTQLYVSIDASNRDSLRKIDRPLHRDFWERFQRCLDILRE
KRFQQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQN
VPFYEEVCAFVEALNAALLRRGLDYGIAAEHAHSCCILIASERFKVDGKWHTRIDYEKFF
ERLESGEEFGPEDYMGPETPEWATWGKGGFDPRDERVYRKGKNKTPLQSDS
>A0A8J8ELE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. GR4|TrEMBL
MAITFKSNPNMPGEIARLFKKQHYALVGRHSSVKLCHWLKESIKHDRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPGPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTAPERLEEMI
KEDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWEKITRTLELMNGLPTRTVIRLTLVKDE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDKTERFIKH
>A0A1R4A5U4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuniculiplasma divulgatum|TrEMBL
MENKYAQVYKKQHYGLVGKHSAVKVCHWTKSEMTGGASCYKGTFYGINSHQCIQMTPALN
SCTENCSFCWRFNGFDSMHIGDEDDPEFILNESIKAHLKLISGFKGNPRVTEEKWKEASN
PKHIAISLTGEPTLYTRLGEFIKLAHKRGMSTFLVTNGTLPMVLEKLNPLPTQLYVTTAG
PDKKTFNELLNPAMGNAWENFQKTLELMPSLDTRKVIRHTLVKDFNMPFIDEYAKMDSIA
QPDFIESKGYVHVGQSIARLSIDNMPSHNDIMDFTVKLGEKVGYEVTAERKESRVSLLAK
DPSKSKINFESI
>A0A1N5T6I1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cuniculiplasma divulgatum|TrEMBL
MENKYAQVYKKQHYGLVGKHSAVKVCHWTKSEMTGGASCYKGTFYGINSHQCIQMTPALN
SCTENCSFCWRFNGFDSMHIGDEDDPEFILNESIKAHLKLISGFKGNPKVTEEKWKEASN
PKHIAISLTGEPTLYTRLGEFIELAHKRGMSTFLVTNGTLPMVLEKLNPLPTQLYVTTAG
PDKKTFNELLNPAMGNAWENFQKTLELMPSLDTRKVIRHTLVKDFNMPFIDEYAKMDSIA
QPDFIESKGYVHVGQSIARLSIDNMPSHNDIMDFTVKLGEKVGYEVTAERKESRVSLLAK
DPSKSKINFESI
>A0A8J8DHV7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. MAR1|TrEMBL
MAITFKSNPNMPEEIASLFRKQHYALVGRHSSVKLCHWLKESIKRDRFCYKQKFYGIASH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPQPWDDPAFIVEESIKAQRKLLVGYKGMP
GINMKKFEEAWNPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
REDKLPTQLYVSLTAPDIETYNRVNVPMIPDGWDRIKTFLEMMNGLPARTVVRLTLVRGE
NMANPEGYAKLIKLANPMFVEAKAYMFVGYSRNRLTINNMPRHEEIKAFAEELVKHLPGY
HIEDEYEPSRVVLIMRDDVDPRGSGREGRFIKH
>A0A811TBH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Argoarchaeum ethanivorans|TrEMBL
MNPLKIHGCRRMLTSSNFESLLKKHGYHMAGSHSAVKTCLWLNKSLRGEGKCYKFQFYGI
ASHRCVQMTPTMQCNQKCLHCWRPTEIDVPETGWDSPELIVEESLKAQQKLISGYGGADI
IDKTLWEEAKNPRHVAISLAGEPTVYPYLDRLVDAFHSKNMTTFVVTNGTYPAMVERINP
TQLYLSLNAPDEDTYRQTCNPQEEGLWERICKSLDILREKETRTVLRITLTEGLNITNPE
GYAALIDRASPDYIEIKAYMHLGFSQKRLERSAMPTHQRIREFSERIMQYTAYKQADESQ
ISRIVLLSKNGDVKKIV
>A0A7C5TX16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidilobales archaeon|TrEMBL
MDTSRIIDHYTEINRSLRKQKYHLIGGHSAVKKCLWTHKVLMDNLYCYKGKFYGIDSHRC
IQMSVSTQWCWNACLHCWRIRPTDILEEWDERRIPEIDDPEFIVEMSIIEHRRTVSGYKA
HNVDPNKIAEAMNPRHVAISLTGENTLYPALGELIKEYHKRNITTFLVTRAVRPDIIANL
DEEPSQLYISLEAYDKEGYEYFNTPLVPRAWEKTLETIEILPSFTCPTVYRITAVRGWNM
SLEAAKGFAKLIERGEPTFVEVKAYMYVGTSTKRLGRENMPSHEEVKEFARILSEISGYK
IVSESRPSRVVLLSKLEKPLIRHGNAPVTWWDPDLTDFSEYEISENIYGEITTK
>A7RV91|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nematostella vectensis|TrEMBL
MKLSMQQGMDCSCENLQGYEAEDNLANEVCTKSTCVFIVPTYTDGKPPRGAEWFYSWLED
STNDCRVSKSLLSQINYAVFGLGNSSYEGQFNLVAKNIDKWLSSLSAKRVMPVTLGDENT
VNSRHGGLEADFQVWCKTFFSLVKSHTLCECGKQETCQETSKSQEETSQACDYESTSDGD
SEDEDTADGLVDMEDLGPAVQKIKKAKKQREIEEDSHKNTVAKEMVTPVIRQSLTKQGYK
IIGSHSGVKICRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNP
VGTEWRWQMDDPQMIVEGAMQNHYNMIKQFRGVPGVKPERFEEGMKIKHCALSLVGEPIM
YPKINELIKLLHGHGISSFLVTNAQFPDAIKDLLPVTQLYVSVDAGTKESLKKIDRPLFR
DFWPRFLDSLKALADKGQRTVYRLTLVKSWNVEEIQSYVELVSLGKPDFIEVKGVTYCGE
SKASTLTMANIPWHQEVVGFVRKLEDQLPDYELASEHEHSNCVLLAHKKFKVNGEWHTWI
DYTKFHQLIEKYEESNGEETFTSADYMERNPEWSVFGHSQRGFDPEETRWYRKNRKDISG
C
>A0A6J8F330|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania donovani|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTAPPAAAEDVICPLVRVMEMREEEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGV
APPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGL
GAPPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAAS
ATEARSCKGGSATVATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCA
CRKADTIADGVAVSKSDDDDDDSNAENDGMDDVEDLVWDGTDDADFDLSKDPSELPELLY
PKLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACA
NKCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLAMAMQI
RHCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRNLKPVVQLYLSIDAPT
PEELKRIDRPLFEDYWDRCLSCVKELARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQP
DFIEVKGVTYCGTSSNSTLNMKDNVPRHDEVIGFCKALCAEMASRHPHYRTPQMDKEEEG
GGDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRTD
FTSLDYAAVTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTASC
>A0A3A5UUT5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniales archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKTCHWTKESLLRDRQCYKGKFYGVQSHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPMELLYESVRAQRRLLSGFGGNPKVPREKWLDAQNP
KHVAISLNGEPTLYTRLAEYMDLCHKHGMTTMLVTNGTFPKILEKLDTLPTQLYVSVDAP
NKKVFDEVCKPKWNTRAWEQFEKTIDLLPSLDTRIVCRHTLMKGINMSDKHIEQFAALDN
RADPDFIENKGYVFVGHSRENLSAENMPRHDDIMDFSAKIAPLTGRKILSDSKPSRVALV
GQEITPIPIPEATMFFPEDLGIAPPVKHLPIIQ
>A0A504XT09|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania donovani|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTAPPAAAEDVICPLVRVMEMREEEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGV
APPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGL
GAPPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAAS
ATEARSCKGGSATVATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCA
CRKADTIADGVADLVWDGTDDADFDLSKDPSELPELLYPKLRQNLEKQGYRLVGSHSGVK
LCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACANKCVFCWRHHTNPISRHFRWKQ
DPPELLIAQGMAGHYQMIKQMRGVPGVTPERLAMAMQIRHCALSLVGEPIMYPQINGFCE
LLHQHRISSFMVTNAQFPEQLRNLKPVVQLYLSIDAPTPEELKRIDRPLFEDYWDRCLSC
VKELARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQPDFIEVKGVTYCGTSSNSTLNMK
DNVPRHDEVIGFCKALCAEMASRHPHYRTPQMDKEEEGGGDVIVIPAEERNRPYHVACEH
EHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRTDFTSLDYAAVTPTWATYNSKEKG
FDPEQTRVVRKNARPTTVTASCYRNGSVATDPPSTVFVSPRTSSMHRSPLASFEEAQEGD
GERAPHNSRYASSTNRPRSSTFIHSVSAYLSTATGKRGASSAATTVRASLANGSSITGNS
ASKPRQSRHQPSLIIASGCSGGAQPNRKKSVASPTVASKRLATYTATATTTRCGTLAPGV
HEDSYTKLESPKGRMPESDLNDANEGVDWACVNVGLGDLVLESMQLARASAAAPQADSVA
STSAGNAGQDKNAGGDSGSMALPPQGRTSPAPEDGIATGPAVMVADDDVANADMNILVAV
RVRPRTSLITAKGAPSTSPLTDTAARRLFPASSASSHSAEQQPPCELRSSGGDWDDALST
QASTAGGGSLVEERQRTTNSTPSHSATVRVRRSASRRAILKAEKNDTGNSDSKGSASKEV
CVSADARNGFIDCAVAVAANASGGASTPAANGAAAGQRIRTLRFRFDCILDDSVTQADIM
ACIGQRAVARVLRGYHSTVMCYGQTGSGKTYTIAGPHGGKLSRKALRWLASQPASAGAVE
CDDSNVDQEEQVRVASDVGLLPRILIQLFRGLEARHGADGRLQQASAAPTSSWQVTLSAL
ELYNNNMRDLLPGELPKNEAATLGKKDVSRPSAATRLRHHGNSSSMSGRRDHRKATASAV
TGGRGQLSASPSPCAAPKHTRVSQRVSSRCGNSATTRAPPTAAASTPRANSHAGASTAMG
SAKTMPMKWTAPTTTKAAPQLQIRLGAPASSASQSSPPTKLKKARAVSPPPSSWASLRQP
AHNAGSEAVYIEGLREHQVHDIHAALEAVWLALRQRQAGSTELNKSSSRSHVFFFVRVEQ
YERRSRDGEKPAWATRRSTLSLVDLAGSERVSHTGAHGLQLKEAQNINRSLSVLGNVMRL
LSSASRSSLSKNLATTSASSAAALTGARADQHIPYRDSKLTHILQSSLGGNAITFLLCNV
SPDSRDAQETMSTLRFAKLCKSVKSNARLNETTADTEDAQAAAEAKICQLAVDASTAQNR
LQQLATASIRAVTSSSRARGSSGGRGLVVPEETTAPKVISGERSAGAGNGGMQRCNSLES
SGVENKEVADSGAPGACWAYVAGRRMELQRKLIAAAAAAITIEDAAMLSMLYSTDAAVGE
AEATARDRVIDGTNPLEVSSTASTASTRTRDGGSGVLVSKPTAIPVSMGVSSASEETRAP
TRHLRSSPPEHAPALQPSPSMAAFSSVPLPSLTANQKQPRLECPMNAIDTTLAEERAARA
ATQARLVEVEQSNLLLRLRLAELHGRMRLEGGSTHFAEGHQLMNAEKATRRTVGKDYSWA
PSSLATAPAPLPSPAEASASRVLWPPHYSRASHDASLKGKAHQKPQWTRGDEGDTEAMQD
LPERCDEDGTARMARAAFGVIATATRALPAMDHPHLALALVIVRASRKSEDSSPSEDMKD
FSMEEEEEGGSARAPPSIAVLVMVRGHYQRQTRPAATSPSPPMSTCRRLSYDSSKTGSNS
RSRTRASLSSVASPHSFSHTLSEEHQQHHFWQRCVTVTEVATVTASRRSAVAAARSGVVV
VANACAKRDDSSLVAEARSPSIRIGPAVLPSSLETTTSSSVVDAHAQVTSKPGGAAGAAN
SGNEGVSPFSRVHIRNTRSSKTTTAGGGSASPPSITVVQAAAAAVVTKHGTPVRANGPSS
PSMPSPFSSTSAPVDTPPQRWDDYSRYQHSVHFQPAPTLRNVGIGGPSPFAAEQLAMPRR
PQPRLAVAPTGDGASVAGCAQSGQTNAKVAAPPLQLVRPADLYRGATTATGTATAGVGGP
ASTAMAASLLPGAAAAQDRLQLPRRSRLARTPSATSVQQRRRTPSAGSFGGGGSARKAGP
VASSSPLKRRTSVSSHSDDAVGPVGGSAARVASRRPRSSTPSGTLSVYTTRGASGGRSPL
GHSEPSRDGAGAPALRRRESSSSRTSSAVPGSVTDQAPRIADRLRVPAVAPSSLVRYSSV
ASVHQRRSHATITTIPVSNAAAAASTSVAEWISSMSTSSAPRRSHSRDGTSGTARSSAAG
KSVRSSLHTAAASAAAKTPSMGTAPTARRPNVGATRPTISSTAGAGGPRARPPRDGGSSN
TVSVSQASMISMEESKAFLQDFQRMNDRELALFGTLLATVASEQQNRRGLGITGDATPSA
DKANATRLVGNAADDRKADIAPPTGVVASAEDVTVWTCKRVISLPSDQQQQQPGQTSDMP
PPTTPGEPAVTAQPALHANEELIVLVRRSRSHSAGLHAPPRSSTSGPEAPPSPKQQQRQK
PAKPLLQPDQLTQRADGTEEKGGGHVAASPHAFVRSPLRHPYSQQQARCTVTDAAAGDRG
SSGAVVLHRASRSPSPTPPSAAIARGEKENGQQARSLHSASSSPVPASPLSTAAGARALQ
QQQQVGALASARADRSSSGKLRPREATDVNTSANRTAAGAARKVAVETMATPARKPHKAP
PSSSGAAAAATAGAVGRRAVRNRSSSSAVGRVRGGSRRRCGANDGVHTPSSLQEHQRQLS
VESYTDIMRCYSPKRLEGLHDGNGGSGCDATLKEERMSIDEGPRAAGASASSLSSAVSEA
AAPLAALKRAKELAAELAAAARARTVSADKPSVGMIPTSFTSPATFSSVDSPTSGSLSMG
RASGGYATGAASEISSVRVTAAQLQLLIDSSRSQANYARYQPL
>A0A3P8V9G4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cynoglossus semilaevis|TrEMBL
MVDNCTVYCVQFAKTMIHLLCIIFLSSRVFATDTKASQNEYSITETYFMSIWNKRLYLYT
LAALVFGAWFLLKALWKKKSLKNVDSGVYKAVKNNEQPHTDKVVHVSGVKIFYGSQTGTA
KVFAQELSEEVKTLGITSDVIDMKDYDPDDRLADECTSKSVCVFLVATYTDGEPTENAEW
FCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTR
GEGDCNVVKSRNGSIQADFLAWKAKFLNRLQSLAKGEKKKCSGDCKTNGSCKKKNRKEDQ
VVEKQQQVEEKTSSEEELMESSSDEDETGGKSGSVVDMEDLGNMMSSVRKVKIKEDRRGG
DLLLNGVKKTEDEDERREMITPALRASLTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEEILQDAMEKHQNM
IRQFRGVPGVKPERYEEGLVVKHCALSLVGEPIMYPEINTFLRLLHSHNISSFLVTNAQF
PEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTL
VKAWNVEELQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVSFVQQLAD
MLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQIYEESGGQRSFSALDY
VSKTPLWALFGAQEQGFDPDDTRFQRRSKTKDISGC
>G2Q2H8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myceliophthora thermophila (strain ATCC 42464 / BCRC 31852 / DSM 1799)|TrEMBL
MEKPEVVVTKDEGSEGSESTETGNNRRAAKHGPRRIRGDINKKKRESAEAGSEGRRIQVL
VFYSSLTASTEKIARTFSQELAASLGCSTEKEAESRFLAPRVLDLAEIDFDEYFITPPKS
ESEPADCFYLFIIPSYNIDSINDTFLEHLRETHHDFRIDTSPLATILGYSVFGLGDREGW
PTEEEGFCFQAKDVDKWMAKLSGRKRAYPLGMGDWKRDGKERMSEWTAGLVDVLRQLEQT
GTLGEGVPGSGDPLESDDEGEAEDDGEVPDEEVSVSKAAKGRSSGSLEDVEDIGRIMEAS
QGGDSGKRSAAPLAIDFTTEGKPAAKKAASAAVKEMVPRSSPTYAALTKQGYSIVGSHSG
VKICRWTKSALRGRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRW
VVDPPKLIFDGVKENHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEF
LGLLHGERISSFLVCNAQHPDQLAALQHVTQLYVSIDASNRESLRRIDRPLHRDFWERFQ
RCLDILRERRFRQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSTSS
SAGLTMANVPFYQEVCDFVVALEKALRKRGLQYGIAAEHAHSCCILLASERFRVDGKWHT
LIDYDKFFQLLEEKGPDGDFGPEDYMGPPTPEWATWGNGGFDPRDQRVDKKGRPIEAA
>A0A7L1YQR0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scytalopus superciliaris|TrEMBL
MDMWNYFHTCVASIWLHRCYIYSAVALGISLWIVIQFTTTRTKKKVTEPCQHFRTEAKLV
NGCATPQAKEVYVAGVKIFYGSQTGTAKGFAKALAEAVTALNLPVEVINMGDYDPDDSLS
EEVASRSVCVFLVATYTDGRPTESAAWFCKWLEEAANDFRFGKTYLRGLRYAVFGLGNSV
YVDHYNTVGRSIDRWLWVLGASRVMSRAEGDCNVARSRHGSIEADFGAWQAKFLSRLQAL
CRGEKKPCSGRCKKGKCKSPGKQSKESSDHEHGASEHENTEAEELFETSSEEEADAEEAE
GTNSVIDVEDLGNIMGHMKKAKREGELQEGGVGMRENTGRKEQQEKREMITPALRDALTK
QGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGTEWHWKMDQPEMILQEAIENHQNMIRQFKGVSGVQAARFEEALAVKHCALSLVG
EPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTRESLRRIDR
PLFKDFWQRFLDSLKALAEKRQRTVYRLTLVKAWNVEELRAYADLISLGKPDFIEVKGVT
YCGESSASSLTMANVPWHEEVVAFVQELAELLPDYEIACEHEHSNCLLMAHTKFKVDGEW
HTWIDYGRFQELVRERERSGGSGTFSATDYTARTPAWALFGSRERGFDPLDVRHQRRNKA
RAISGC
>A0A8C0FMS8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bubo bubo|TrEMBL
MDMWNFFYTCLASLWLQRFYIYSAAAFGISIWIVIQLTTKTKKKGAKSHGNPAAAEEDKL
VNGHATLQAKEVCVAGVKIFYGSQTGTAKRFAKSLAEAVVSLNLPVEVISMGDCDPDDCL
SEETSSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRFGNMYLKGLRYAVFGLGNS
VYVDHYNTVGRNIDRWLWMLSARRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQM
LCRGEKKPCSGKCKKGKCKSPGKQSKESSEREQRASEYENTEAEELFETSSEEEADAEEA
GGTNSVVDVEDLGNIMSHMKKAKRERELEEGDVGMSLTRETAGRKEEGEREMVTPALREA
LTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFC
WRHHTNPVGTEWRWKMDQPEMILQEAIENHQNMIKQFKGVSGVKAARFEEAMTAKHCALS
LVGEPIMYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKR
IDRPLFKDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEVK
GVTYCGESSASSLTMANIPWHEEVVLFVQELADLIPDYEIACEHEHSNCLLIAHKKFKIN
GEWCTWINYARFQELVQEHERSGGSKTFTAADYTARTPHWALFGSRERGFDPLDVRYQRK
NKARDISGC
>Q755C2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)|TrEMBL
MCGANLDAEEPFLSGIPGSAILAAVLASYIGTGGRISIGCVVTALYLLANIEAKKNASFA
AALGVPVSGKGKGCCGGKNGGCCSTKAAAKPTGHKCSCSGAKVTKSKAPVAASAAARSQE
EAFPIAIDFTNSFKAPQSKVPPVKKTPKVISGTAKKKQKDAFIKSGLTVSNEKLLASQIY
IFYSSLQGAAKRSAELVLAELRELKPLELEPILLNLDEIDDLDKYFVDVPCENALYVLVL
PSYDSDSPLDLFLETLEENFNDFRIDNYPLRKLVGYSILGIGDSEMWPEKFCYQAREADL
SIAKLGGRRIYPVGEVCVKFGGDPKVEEWARLFVETLQDDEPMLYEYDESVEDELDESSD
AAAEALVDLEDIGNGSGGNGTGALKKMVAKDSPTYKNLTKQGYSIVGSHSGVKICRWTKN
DLRGRGSCYKHSLFNIVSSRCMELTPSLACSSKCVFCWRHGTNPVAKNWRWELDEPEFIL
ENALKEHYSKIKQMRGVPGVIAERFAKAFQVAHCALSLVGEPILYPYITRFIELLHQKNI
SSFLVCNAQHPDQLEALGKVTQLYVSIDAPTKTELKRVDRPLYKDFWERLMRCLELLRTS
QAHQRTVFRLTLVKGFNMADVSSYADLVQKGIPCFIEVKGATFCGSSDGNGNPLTMQNIP
FYEECVSFVKEFVAELQKRGLAYDIAAEHAHSNTVLIAHTKFKRGDKWYTHIDFEEFFKL
LNSGASFTHMDYMAETPEWALFGNGGFAPGNTRFYKKKNRKDEASVREGKLA
>A0A6P3ZTF5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Ziziphus jujuba|TrEMBL
MPTMSFSSFPTRLTLLALLSATTFYCFYKSRRLKLLSQSLNPNGKTSSSSPRKAKLFFIS
QTGTSKALAVRLFDLLTSNNLAFDLVDPNHYEPEDLPKENLVLIVASTWEDGKAPPTAKF
FANWLSESSDDFRVGSLLLSQCKFAVFGVGSRAYGATFNAVAKDVSKQMRALGAKEILPV
WEGDVDGGDIDEVFDAWSGKVVGFCKGGVVENGGVSTNGVDCESDACSGDETDEEEYSME
SEIVDLEDIAGKGPSRRSATVTKAETNGTLNGKKDMVTPVIRASLEKQGYKIIGSHSGVK
ICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKM
DDPLEIVNSAIEQHTKMIKQMKGVPGVTVERLREGLSPRHCALSLVGEPIMYPEINTLVD
ELHRRRVSTFLVTNAQFPEKIKMLKPITQVHILALTRTAASALTLIKFPARETQ
>A0A3B3HU72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oryzias latipes|TrEMBL
MLIEAMAKCLIVVLFFARCAFASDVNAPQTGSSLAENYLALLWHHRLYLYAAAALVVGLW
VSLKVALSRKSGEKDAVLSGAKKQEEPEVHVSGVKIFYGSQTGTAKGFAKVLSEELEALG
FPAEVIDMKDYDPDDRLADECVSGSVCVFLVATYTDGQPTESAEWFCKWLEDASTDFRYG
RTYLKGLRYAVFGLGNSVYVGHYNTVCKNVDKWLWMLSAKRLMTRGEGDCNVVKSRHGSV
QADFQAWKGKFLSRLQALATGEKKTCSGKNCKTGSSCKSKKEEEEASKETGSEVELVESS
SDEDESGLTGEKRSVVDLEDLGNLMKNAKKAKGKNGPQRDGEVVKFSKLNGVKKIDDDGE
RREMITAALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETT
PSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALDKHQDMIRQFRGVPGVKPERY
EEGLAVKHCALSLVGEPIMYPEINAFIRLLHSRRISSFLVTNAQFPEEIRSLEPVTQLYV
SVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVEEMQAYAEL
IALGQPDFIEVKGVTYCGESSASTLTMANVPWHQEVVAFVQQLAAMLPEYEVACEHEHSN
CLLIAHEKFKLDGDWWTWIDYERFQDLVQAQQDSGGRQTFSALDYMAKTPSWALFGAREQ
GFDPADTRFQRRNKTKDISGC
>A0A497TBK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MIPEPLRKSLVNQHYKIIGNHSAVKLCGWLKRSLKDQGYCYKQKFYGIQSHRCLQMTPWL
ACSNRCVYCWRIIEKLNIKPEEIDEPETIIEGSVQAQRELISGFKGYEGTNLKKWKEAKN
PNQAAISLVGEPTMYPKISDLIKEFHRRGFTTFLVTNGLFPERLENLEAPTNLYISLDAP
DPETYERIDRPKLKDYWERLLRSLEIMNSFRTRRVIRLTMVREWNMHSPEKYAKLIEKAN
PDFIEVKGYMWVGESRKRLPSEAMPSHKEIQEFADKLSKETGYVQKDEQEESRVVLLSKV
>A0A7C4CHE5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Aenigmarchaeota archaeon|TrEMBL
MSLIPEDAEKRFFRAGYRIVGNHSAVEVCHWTKESLRRGRVCYKEKFYGIKSHRCLEMTP
ALIWCTHKCKFCWRPLEFTILGEPKPDDPKEIVEGCIEARRLLLTGFKGFEKVDKKKWEE
AIKPTHAAISLAGEPTLYPRISELIKEFHKRKMTTFLVTNGTRPDRLSSLEEEPTQLYIS
LCAPDEKTYLEIHNPLIPDGWKKLNESLELMKSFSCRKVIRLTLVKNLNLKDPEKYAKLI
LKAEPDFVEPKAYMWVGESQKRLKKEAMPSMEDIRNFAEELSFHTGYKIKDEDLASRVVL
LSKK
>K1WQX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marssonina brunnea f. sp. multigermtubi (strain MB_m1)|TrEMBL
MPLDKFFRPLLPFEVADLIALWHIHRIPIILSTVTVLIVARTYLHIRCPRYKIPDTPPIS
PALPALNGKSTPPEKKAVAAVEKAPRRIVGGLKRRKSSQEDIKPRKQKIRVLVFFSSLTG
TTEKIAKAFTEEIAQSTRKIAETTSTTFLEPVILDLSYIDYDEYFINPPKNDSGAQYFYL
LLLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSTILGYSVFGFGDRDGWPTEEEGFCSQ
ARDVDKWMAKLTGKKRAFPLGMGDSKSDATERLAEWKEGVEDVLGHIAATGSLGEGVVGS
GDAVESDMEDVDDEDDVLFDDQKIAQRKTKAQKKDALNDLEDIGSAMNKQASIPGADLDD
EPLEVDFTTYGKNPQSKPTPVIKEMVPKNSPTYTALTKQGYSIVGSHSGVKICRWTKSAL
RGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDAPDLIFDG
VKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFTAMLHKEHISS
FLVCNAQHPDQLAALKPVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILKERRF
EQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAGAGLTMQNVPF
YEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILLASERFRVGGKWHTRIDYVKFFQCL
ESKEPFRPEDYMGPETPDWATWGKGGFDPRDERVYRKGKNKVALTEKQGVVMEI
>A0A1V6N0I0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter arboriphilus JCM 13429 = DSM 1125|TrEMBL
MSNSLINQEKNVSLSLEDQKKLEYSGYRFLGSKGHSAVKICHWTKKSILNEGFCYKEKFY
GIESHRCLQMSPAVPFCHQKCSFCWRDLSLTKTKWVGDYDDPKTIIQDAIHAQNKLLCGF
FGNDKADRKKLEESKKPNNAAISLAGEPMFYPDINDLIAEFKKQDFTTFLVSNGVIYEKL
ANLQNEPTQLYLSLDAPDKKTYVDLCTPQINDAWLNINKSLETLNSFDSRTCIRTTCVKH
KNMFDHENYAKLIDLANPDYIEIKAYMCVGYSRDRLTLDNMPTFNEVIDFAQKIADLTGR
EITNDSEISRVVLLE
>A0A2A3T3X5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosopumilales archaeon|TrEMBL
MQIRPSIVKQLKKAKYGVADHSTVGLCHWTKKSFRGEGTCYKHKFYGISTHRCMEFSPAG
MYCENRCVYCWRPMEFYDSMEMQPQNVAEPEDIITKLMAERKKLIMGHYGDPNQDKKKLD
ESLLPSHYSISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQEPDMIQKLGDENALP
TQLYLSTNAADYKSFLKINRPRYDDSWERWNXTLKMLSTLGTRTVLRITLIRGYNDDEEM
IPVFASLLQKSNAHFVEIKSYMHIGRSTNRLEHSDMLEMDEVRSFANKLAQENSDFTVMD
ESGISRIVILQNKKRFVDRFIPACC
>A0A524I1F3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomassiliicoccus sp|TrEMBL
MKKDLKEILQKQQYRLCGDHAGVKLCHWMKQSLLKGRTCYKQDFYGIRSHRCLQMTPVVN
DCTHNCLFCWRVRGFESTVTKWQDPEVVLDTCIEGQRQLITGFKGDPRCSPAMWQEAREP
KQVAISLAGEPTMYPYLGDFIELCHRRGMTTFLVTNGTFPDVLEKLSTLPTQLYVTVAAP
NEEIYRQLCVPRFPDGWERIRRTLELLPSLNTRTVIRHTLVKGWNLGWEKEYASLDRLAD
PTFIEPKGFVFVGDSRRRMSMENMPSHAEVLEFGRRLAQDLGITLLNEKSASRVAVFGEE
GTSTKIPGLE
>A0A842KSS5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacteriaceae archaeon|TrEMBL
MSKSEKFKRLEKMGYRFVGKHAHTAVKTCLWTKKSILDEGTCYKQKFYGIKSHRCLQMSP
SIFFCQQRCLFCWRDLKYTRTEWDGDYDKPADIIDECINAQRTLLCGFFGNEKANKKKLL
EAQEPNNAAISLAGEPLLYPMINEMIKEFHKRKFTTFLVTNGINYKALENLSEEPTQLYI
SLDAPSEEIYNKICRPQTENAWEHLNRSLELLPSFNCRRVLRITAVHGKNMTNPRDYASL
IKKAQPDFVEVKAYMYLGYSRQRLEMENMPLFFEVYEFADKIAELTEMDIINKSKESRVV
LLGQS
>A0A8H2ZTK6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sclerotinia trifoliorum|TrEMBL
MAYDTWISRPIWSYGIEDIVALWHLHRIPIILTTATILILVRITLRPRASREKLSASPLP
TSPILPAVKEKISAPVIEEKKANGVKAPRRIVGGVKKRKPSEENLQTSPEKIQILVFFSS
LTGTTERTASCFLEQLAGDIRESGFERTTPIKYLDPEQLDLSYIDYDDYFINPPKGEAGT
KYFYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLVGYSVFGFGDREGWPTEEE
GFCSQAKDVDKWLAKLTGKKRAFPLGMGDAKKDARERLTEWREGLVDVLEHIARTGSLGE
GVVGSGDAVESDVEDIEDDDGEVLFDEQNVASRKAKTQTKDDSLNDLEDIGGVLNNTETI
DNTVSEGSEELEVDFTTIGLKKGKTKTAPVVAKEMVPKTSPTYAALTKQGYSIVGSHSGV
KICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWK
VDPPEMIFDGVKAGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFT
SMLHKEHISTFLVCNAQHPDQLATLQPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFQR
CLDILRERRFEQRTVFRLTLVKGFNIDDEAEGYADLVEKGLPCFVEVKGVTYCGTSSSAG
AGLTMQNVPFYEEVCAFVEALTSSLKRRGLGYGIAAEHAHSCCILIASDRFNIAGKWHTR
IDYKKFFECLESGEKFGPEDYVGDETPEWATWGNGGFDPRDERVYRKGKNKVPLPESQGM
VMGEVQDGNEDKVAGDTLAF
>A0A2V3JF67|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|ANME-2 cluster archaeon|TrEMBL
MKPELENLLKKHGYHIAGRHSAVKTCHWLNRAIRGEGSCYKSQFYGVRSHRCVQMTPTLS
CNHRCLHCWRPVEMPVPLPEPADWDSPVEIKGSIMREHARLISGYGGSETTDMDALTEAQ
KPDQVAISLAGEPTLYPYLPELIDLFHKDAMTTFVVSNGTQPDMIARIAPTQLYLSLNAP
DEDTYLKVCNPHGNFWEEIQESLRVLGRSKTRTRTAVRITLIKGVNMFDPEGYARLLRMC
EPDYIEVKAYMHVGFSQKRLDRAAMPDHEEVRIFASEIGDAAGYRIADDSAISRVVLLSR
DGGVERI
>A0A368PDV4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|ANME-2 cluster archaeon|TrEMBL
MKPELENLLKKHGYHIAGRHSAVKTCHWLNRAIRGAGSCYKSQFYGVRSHRCVQMTPTLS
CNHRCLHCWRPVEMPVPLPAPTDWDSPVEIKGSIIREHARLISGYGGSETTDMDALREAQ
KPNQVAISLAGEPTLYPHLPELIDEFHKDAMTTFVVSNGTQPDMIARIAPTQLYISLNAP
DEDTYLKVCNPCGNFWEEIQESLRVLGRSKKRTRTAVRITLIKGVNMFDPEGYARLLHTC
EPDYIEVKAYMHVGFSQKRLSRAAMPDHEEVRLFASEIGDRVGYRIADDSRISRVVLLSR
DGGVEQIQGRG
>A0A8D3CUW3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scophthalmus maximus|TrEMBL
RCRVNDCLLEQSLSQDEHSPGESYFLSVWHNRLYLYSAAALVFGIWFSLKMALKKVNGVL
LIPPPHPHSLTPDPLGEYTVVHVSGVRIFFGSQTGTAKGFANELSEEVKTLGIPAEVTDM
RDYDPDDQLADECTSKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTFLKGLR
YAVFGLGNSVYDGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSIQADFLAWK
VKFLNRLQALAKGEKKGCRGDCKTGASCKNTRKEEQVVEEKANSEEDLMESSSDEDESGL
QDEKKSGSVVDMEDLGNIINIAKKAKSKEEGGGGGQVVKLSKMNGVKKIEDEGEKREMIT
PALREALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACA
NKCVFCWRHHTNPVGTEWRWKMDPAEKILQDAVENHQNMIRQFRGVPGVKPERYEEGLAV
KHCALSLVGEPIMYPEINTFLRLLHSQHISSFLVTNAQFPQEIRTLVPVTQLYVSVDAST
KDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMQAYSELIALGQP
DFIEVKGVTYCGESSASTLTMANVPWHQEVVVFVQQLADMLPQYEIACEHEHSNCLLIAH
TKFKVAGEWWTWIDYERFQELVQAHGDSGGQQSFCALDYMAKTPGWALFGACEQGFDPAD
MRFKRRNKAKDISGC
>A0A842NDV6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosopelagicus sp|TrEMBL
MSCSGEIVDKEDGLIQIKSSISEQLKKAKYGVADHSTVEICHWTKKSFRNEGSCYKHKFY
GISTHQCMEFSPAGMHCENRCVYCWRPMEFYDSMKMDEGKVAEPKDIMSKLMEERRKLIV
GHFGDPKQDKQKIEESLTPSHYAISLSGEPTMYPKLPDLIKYLKSLEATKSIFLVTNGQE
PEMIQRLADENALPTQLYLSTNASDYDTFLKINRPKYDDSWERWNKTLEMLAELDTRTVL
RVTLIKDWNDSEKMITGFASIFEKSNAHFVEMKSYMHIGRSTNRLEYENMVDMADIRKFT
EKISSKSDRFEVMDESEISRIVVLQNKKRFTERFLSAYA
>A0A7K4FYP3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nitrosarchaeum sp|TrEMBL
MSCSGETVEDEDKLIQIKPGIAQQLKKAKYGVADHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLKMEPEKVAEPKEILTKLMEERKKLIM
GYYGDSRNDKQRLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYDSFLKINKPKYDDSWQRWNKTLEMLKQLDTRTVL
RITLIRNYNDQKEMIPAFASMLKQASPHFIEIKSYMHIGRSTNRLEHSNMLEMDEVRKFS
EEIAKQSQIFSIMDESLVSRIVILQNNHRVIDRWISAYANTN
>A0A1V9ZVH4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thraustotheca clavata|TrEMBL
MVSIRAPHVAMAAAGLALIMASIAYVMRKEVAKDRSLPVKKSQENQCCNNGQCEKESKPV
TVRILYGTHTGTARGFAETLQKKIFALNIAGYAFEPSVVDMKDYDQDNLEHEQVVISILS
TWTNGVPPESAKVFCNWLQDMELDFRVSKTWLKHLAVATYGLGNAEYDEHYCTAAKQLSK
NFNTLGASRICKRGDGDDNQDQSKHFEQWSDQLIAALCEQYGGLAQPKNNKEWVSQKEFR
RQKRKEKAIAAGTDNEQVMITDEDRMNEIVLEDEDADEPVNKGDGVVDVEDLGVVMKESE
AAALSREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGITSYQC
METTPSLACANKCVFCWRHHKNPVGREWRWKTDDPVELVEGAISRHQTMIKEVKGLPGLI
QSRWEEAFTVKHCALSLVGEPIMYPHINEFCRELHARNISSFLVTNAQFPDKIAELEPIT
QLYVSVDAATKDSLKAIDRPLFKDFWERFLSCLRQLKEKGQRTVYRMTLVKEHNMKEIDN
YVELIQIGQPDLIEVKAVTYCGKSDASDLTIKHVPYHEEVRSFCELLCSKLDGEYGLATE
HAHSNCVLIAKTQFKIEGQWHTWIDYDKFHQLVQQYYKDGTTFTTMDYIARTPHWAVYDA
PEHGFDPVETRFRRTKEGKVVEIEYTATDSGCG
>A0A061FJV1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Theobroma cacao|TrEMBL
MSPSSLSARLTLLALLSATTFYFLYKSRRRLKPLRQLPINSNPRKGKLFFITQTGTSKAL
AQRLLNLLSSNNIPFDLVDPQNYEPEDLPKESLILIIASTWEDGNPPQGSKFFVNWLAEI
STDFRAGNLLLSSCKFAVFGVGSRVYGETFNAVARNLGKRLRGLGATEMVAVGEGDVDGG
ALESVFKEWSEKVVRVLKGGLVVENENGIVYASDAESFESDDDDNGGGGGEEEIVDLEDI
AGKGPSRKKSVNVAETNGKMDGKREMVTPVIRANLEKQGYKIIGSHSGVKICRWTKSQLR
GRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDDPLEIVNTA
IDLHTKMIKQMKGVPGVTQERLTEGLTPRHCALSLVGEPIMYPEINMLVDELHRRRISTF
LVTNAQFPDKIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLKALRDKQQR
TVYRLTLVKGWNTEDADAYSKLFSIGKPDFVEIKGVTYCGS
>A0A317WFL4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus eucalypticola (strain CBS 122712 / IBT 29274)|TrEMBL
MDASANEGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
REKTISQSTEKDVKADSQPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPPVSFI
QPIIFFASLTANTERYAQVLLEDLRAAARDRADPESRERGLLPPQIHDLSYVDFDDYFIS
APKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGF
GDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGLQDIL
GDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKRNKNQSVVDLEDIKFSSDA
ASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSAL
RGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNG
VKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISS
FLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRH
YQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPF
YEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLL
EKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAAEAQG
>A0A7K7YA81|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thryothorus ludovicianus|TrEMBL
LDVSMDTWSYFHTCLVSVWLHRFYIYSAVAFGISLWIVIQFTTTRTKRKKSHGNPSSSEG
PASKLGNGCASPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVASLNLPVEVIDMGDCD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKGFLQGLRYAVF
GLGNSAYVDHYNTVGRRIDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFL
TQLQALCKGKKKPCSGKCMKGKCKSSGKQSKESSDHEYGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHMKKAKVLLLEGVWNVSHSGYHLVYFVCQFLQAKFNCLMICAL
FSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILQEAIEKHHNMIRQFKGVAGVKAARLEEALAVKHCALSLV
GEPIMYPQINHFVRLLHHHGISTFLVTNAQFPEEIRKLEPVTQLYVSVDASTKESLRRID
RPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKTYAELISLGKPDFVEVKGV
TYCGESSASSLTMANVPWHGEVVSFVQELVRLLPEYGIACEHEHSNCLLIAHSKFQVDGE
WRTWIDYSRFQELVREYEQSGGSRTFTAAEYMARTPPWALFGAREQGFDPSDVRFQRKNK
ARDTLGC
>A0A2R6MGY8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon SW_8_65_20|TrEMBL
MSDSGPKQVDDPEYHSRNHTAAQTCGWTASALRGEGRCYKNTFYGIQSHRCIQMTPVVKC
NERCVFCWRDHTGHAYELDEVEWDDPEAVVDASIDLQQTLLSGFGGNDQVPSGVFEEAME
PRHVAISLDGEPTLYPYLPELIEAFHDRGITTFLVSNGTRPEVLRACDPTQLYVSVDAAD
RHTFDETVAATEDDAWERLLDTLDVLAEKEETRTVIRTTLVDGFNMHTPEWYAVMCERAD
IDFLEMKAYMYVGHSRSRLGHEHMPSHDEVKAFTERVGSFLPDHDTLREVADSRVTLLAR
DEDTWVPKLKGDSEFWA
>M4YUF0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon (strain BRNA1)|TrEMBL
MDEEYRSTLVKQQYRIYNDHAAVKLCGWLKQSMLHERNCYKQDFYGVQSHRCLQMTPALN
ECTHTCPFCWRIEGKDFEVKEWTEPKEMLDALIARQRKLISGFKGDERCDIGMFNEAMEP
NQVACSLAGEPTLYPYLGEFFRECHSRGMTTFLVTNGTMPERIENLSTLPRMLYVTVAAP
DRETYIRTCRPKIRDGWERLMRTLEILPDLRTRTCIRHTLVDGYNFFRPEDYARIDRIAE
PDLIEPKGYVFVGGSRQRLSLSNMPTFEGIREFALKLGEEMGMTLLKEKMDSRVVLLGHE
GMELDVRKAWENGLPPSPRMSRLEGGN
>A0A4W2H3R5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos indicus x Bos taurus|TrEMBL
MFIPNEVGRRLKLDGYCVYFKNKNSPEKTTPKASQNLMTNGYISRPKKEVFVSGVKIFYG
SQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDDRLIEEVTSKNVCAFLVATYTDGQP
PESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLGNSVYLSHFNTVGKNVDKWLWMLGA
HRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRLQALRKGERKHCGGNCKKGKCESNQ
RGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESDTEDHQSSNPVIDVEDLGKIMDHVK
KEKREKEQLEGETSAIRSTVKSEASERRAMITPALREALTKQGYQLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMI
LKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCALSLVGEPIMYPEINKFLKLLHECK
ISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSLKKIDRPLFRDFWQRFLDSLKALAA
KQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESSASSLTMANVPWHE
EVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFKIGREWWTWIDYSRFQELIQEYEDS
GGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQRKNKSKDISGC
>A0A6B9TI39|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothermobacter sp. THM-2|TrEMBL
MYAEKSQRRMERMGYRFVGENRHSAVKTCLWTKKSIINEGFCYKEKFYGIRSHRCLQMSP
SVPFCQQKCLFCWRDLSSTETAWNGPHDEPADIIEGAIEAQRKLLCGYFGNERADKIKVL
EAQDPTNAAISLAGEPLLYPDMDGLLAEFHKRNFTTFLVTNGLASSNLEALSVEPTQLYI
SLDAPDRETYEKLCRPQIPDAWDLLNRSLEIMPSFNCRKVLRITAVRDINMKKPEMFARM
IERAQPDFVEVKAYMYIGYSRKRLEIDNMPLFYEVHEFADSIADSCGMEIVDESRESRVV
LLA
>A0A8C4VV34|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Gopherus evgoodei|TrEMBL
MDASVNTWSYFYTHLMSIWLNRFYIYSCAAFGIGIWICFQFLATKAKKQDEKSTEKLTLS
KVTQDVLINGYTKPKMKEVYVTGVKVFYGSQTGTAKGFATILAEAILSLNLPAEIINMRD
YDPDDCLAEEATSKNICVFLVATYTDGQPTENAAWFCKWLEEAVNDFRFGKTYLKGMRYA
VFGLGNSVYVDHYNTVGKNIDKWLWMLSASRVMTRAEGDCSVAKSKHGSIEADFDAWKAR
FLARLQALRKGKKKPCSGNCKKGKCKSKGRQSKEGSDREQRVSEQENTEKECELEEEAGK
TGPSQQSSGKNEDSERREMITPGLRDALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILQEAIENHKSL
IKQFKGVPGVRVDRFEEGMVVKHCALSLVGEPIMYPEINTFLKLLHRHNISSFLVTNAQF
PVEIRNLEPVTQLYVSVDASTKESLKKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTL
VKAWNVDELKAYAELVSLGKPDFIEVKGVTYCGESAASNLTMANVPWHEEVVHFVRELAD
LIPDYDIACEHEHSNCLLIAHKKFKIDGEWCTWIDYDRFQELIQEYENSRGSKTFTAADY
VAKTPHWAVFGSRERGFDPLDTRFQRKNKTKDISGC
>A0A8J8KD88|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena sp. SYSU A121-1|TrEMBL
MSDSADTGVEGGTDTDADREEGADGGAMQVSSPDYHSENHTAAQTCGWTANAVRGEGKCY
KYIYYGIESHRCIQMTPVVRCNERCIFCWRDHQGHTYEMDDVEWDDPEAVVDASIRLQKK
LLSGFGGNDEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFRDRDITTFLVSNGT
RPEVLRECDPTQLYVSVDAPERHTFDQVVGATEEDAWERLLETMDVLAEKDETRTVLRTT
LVKGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSAMPDHEEVMAFADEVKA
YMPEFTESRGVPESRVALLAKQKDTWVPKLKKGSEFWERDPVVGD
>A0A4S3TLX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Salinadaptatus halalkaliphilus|TrEMBL
MSDSEESPQQVGSPDYHSENHTAAQTCGWTANALRGEGKCYKNIYYGIESHRCIQMTPVV
RCNERCVFCWRDHQGHAYEMDDVEWDNPEAVVDASIELQKKLLSGFGGNEKVPREAFDEA
MEPRHVAISLDGEPTLYPYLPELIDAFHDRNITTFLVSNGTRPEMLADCDPTQLYVSVDA
PERHTFDQVVKAMEDDAWDNLLETMDILAEKDETRTVLRTTLVKGENMHHPDWYAGFYQQ
ADPDFVELKAYMHVGHSRGRLDRSSMPDHDEVVDFAESIAEYMPDFTECKDVPASRVALL
SKTRDTWVPKLKKDSEFWAQDSVAGD
>S8CSW0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Genlisea aurea|TrEMBL
RFALLAVLSATAALFFLYKSRQRRRQLHSRLRGAVNRPLRPPERGKILFLSQTGTSKGLA
RRLHALLTAENLAFDLVDPKDYEPEDLCKEKLVLIVASTWEDGGPPRNGSFLMNWLTDSA
DDFRVGSLLLIDCNYAIFGVGSKSYGATYNAVASSMSLNLQKLGATELIKLWEADVDEDD
VNEAFEQWSKNLVAVLKGSSMKNDLQLSLQGYAFEENESEGEEFSDDDDDDEGVNKLDVV
DLEDIAGKAPTRRSVSEAAKANGKVNGEKREMLTPLVRANLEKQGYKIIGSHSGVKLCRW
TKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWKMDEPL
VIVNTAIDLHVKMINEMKGVPG
>A0A150IWR6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MEKVWSILKRQKYRIVGEHSAVKICHWTKKSLTEGRVCYKQRFYGIESHRCLQMTPSVAW
CTHKCLFCWRPVEYNEEIPSKYDDPETIIEGCIEAQRELLSGYHGFLEKVDINKLKEAED
PTNVAISLAGEPTLYPDISGLIDGFKKRNFSTFLVTNGTTPEVLASMDTYPDNLYITLPA
PTKDTYERVCNPQIKKGWENLNESLELLPKIKTKRRILRLTLVKDFNMADIDEYSKLIEK
ANPDFIEAKAYMFVGYSRKRLEVENMPMFDDIVEFSKELEEKSGYKIVDSAPESRVVLLS
RD
>A0A150J4S9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Methanofastidiosum methylthiophilus|TrEMBL
MENVWSTLKRQKYKIVGANSAVKICHWTKKSLTEGRVCYKQRFYGIESHRCLQMTPSVAW
CSHKCLFCWRPVEYNEEKPSKYDDPETIIEGCIEAQRELLSGYHGFLEKVDINKLKEAEN
PNNVAISLAGEPTLYPEISGLIEGFRKRNFSTFLVTNGTTPEVLSSMDSYPDNLYITLPA
PTKETYEHVCNPQIKNGWEKLNESLELFPKIKTERRILRLTLVKDYNMADIDNYAKLIEK
SKPDFIEAKAYMFVGYSRKRLEIENMPTFEDILEFCKDLEEKSGYKSVDSASDSRVVLLS
RN
>A0A117SW72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caldivirga sp. JCHS_4|TrEMBL
MGESRVKVTLRYHEFADGRIVISRDALATLKKAHYGVYGHATVELCHWTKSALTGGPSCY
KVKFYGAPVGGSHRCVEMGPVGMMCSNKCIYCWRPSESFDPYEPGYGEVMSPEEIINGVL
KERRRLLSGYFGHSRSSRGKVLESLQPTHWAISLSGEPTMYPRLPELIKAIKALPNTKSV
FLVTNGLYPEMIERLWREDALPTQLYLSLNAPNRELFYKIANPVIHRDDAWERVLRSLEL
LSKIPTRTVVRITLIRGWNTMEDLIPQFAEVLGIGNPHFIEPKSYMNLGHSVYKLTKDNM
LRHSEVREWSMILLKALRDKGMDYVFMDEDPNSRITVLQNMKRYVDRWIEKPTNP
>A0A1D2WCY2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosphaera sp. A6|TrEMBL
MIISQTKQKDLEKKGYRFAGKNIHAANKICHWTRKSIVDEGTCYKEQFYGIKSHRCLQMS
PAIAYCQHKCLFCWRDTDITKTSWDSDDYDDPKTIIEDCIENQKKLLCGFFGNENANPEK
LEECVKPNNAALSLAGEPLLYPEINQLIEEFHKQNFTTFLVSNGENPDKIEALGKHEPTQ
LYISLDAPNKEIYKKVCKPQVSNGWEKLQESLELLSTIDTRKVLRITSVKDLNMIHTEEY
AKIIEKADVDYVEIKAYMFVGDSRNRLQWENMPKTVDIQEFAQSIAEKTSMDIIDEVEKS
RVLLLGEKKPGKYNN
>A0A7G9YYG0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcinales archaeon ANME-1 ERB6|TrEMBL
MEPEATSNYNEAEETKTRKTLEKQGYHFVGTHKHSAVKTCLWLWKSIRGEGNCYKGKFYG
ISAHRCVQMTPSIFCNQRCVHCWRPLEAFNINRGAEAEEAVWDSPEEIAEGCLKEQKRLI
SGFKGSPKTDREVFAEAESPKHVAISLIGEPTLYPYLKELIQEFHSYGMTTFVVTNGTNP
DVVREIEPTQLYLSLNAPDEPIYKRVAHADYWSRINESLDELRMKKGKTRTVIRITCMQG
LNMLNPAGYAELLKIANPDFIEVKAYMHLGYSRKRLPREAMPAHRQVKEFASEIAERLAA
AASDANTKANANYNYRVVDESEISRVVLISNVSLEKKALLKKP
>A0A1L9US96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus brasiliensis (strain CBS 101740 / IMI 381727 / IBT 21946)|TrEMBL
METSANEGLLAFWHSYRLPLLLALATIVVLVRAYRKLQPKSKIATASSIPSSPRSHSPEK
TEKTINNSMVKDVETENSSVAEKDASQKQAGPKRVTGKKPLKVAGRRKSSDQEPAVSFIQ
PIIFFASLTANTERYAQVLLEDLRAAARDRADPDNRERGLLPPQIHDLSYIDFDDYFISA
PKPPSTSPGTRYVYCMLIPTYNIDTVLNTFLGHLDETHNDFRIDTAPLSGLAGYSVFGFG
DKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKSDAESALKEWSSGLQDILG
EIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSNKENGRKRNKNQSVVDLEDIKFSSDAA
SGSPIPVDFTTGGKTSAPATDKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKYSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGV
KEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSF
LVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHY
QRTVFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFY
EEVQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLE
KEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKALQAAAEAQG
>A0A669BYK6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Oreochromis niloticus|TrEMBL
MRCSAVPRLLFSQLDARSPTESYFMWLWHSRLYLYSAAALVFGLWFLLKKVRHLLIPYSN
LSDKAPKKNDRETKEVHVSGVKIFYGSQTGTAKGFANELSEEVKALGLPAEVIDMKDYDP
DDQLADECISKSVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFG
LGNSVYVGHYNTVCKNVDKWLWMLSGRRIMTRGEGDCNVVKSLNGSIQADFLAWKVKFLN
RLKTLAKGEKKSCSGKCKTEGSCKNKRKERQEEEKKTSPQNNSSEDDLVESSSDEDESGL
PDEKKTVLDVEDLGNIMNSVKKAKVSKEESQRDGQMVKLSKLNGVQKIEDEGERREMITP
ALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACAN
KCVFCWRHHTNPVGTEWRWKMDPAEKILEDALEKHQNMIRQFRGVPGVKPDRYEEGLAVK
HCALSLVGEPIMYPEINNFIRLLHHHQISSFLVTNAQFPQEIRSLVPVTQLYVSVDASTQ
DSLKKIDRPLFKDFWPRFLDSLKALGEKKQRTVYRLTLVKSWNVEEMQAYSELIALGQPD
FIEVKGVTYCGESSASSLTMANVPWHQEVVTFVQQLADMLPEYEIACEHEHSNCLLIAHT
KFKVDGEWWTWIDYERFQELVQAYDESGGQQTFSALDYVAKTPSWALFGAQEQGFDPAET
RFQRRNKSKDISGC
>A0A0V0YD30|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella pseudospiralis|TrEMBL
LDNTENIWKAYYKMLERILHVFFPSDMITFNLCESVLIIVGISTALIVILLYIIMKKKEK
EEHREDVKIFFASQSGNAQKLAYNLHSRLKSTFSTAVFDLQHYDPEGHLENEQAVCIFIV
STYVDGQCPEKCRWFFKWLEECVSDFRVQKSILSNLRFAVFGLGDKAYRSTFNKVAINLS
KHLLLLKANNILPLYLTEEDNFDHIQSDFFKWSLQLIKYLEDCSSKFSSVHDNKRVSVWH
DENENSSDAEDAENSANNVGDIEDIYFTNVTNDSDKIKEMLTPTLKKSLTKQGYHLVGTH
SGVKICRWTKSMLRGRGGCYKHTFYGINSHQCMEMTPSLACANKCVFCWRHHSNPVGTEW
KWKTDSAEKILFDSLEGHKKMVRQFRGVPGVKDARFEESSTVRHCALSLVGEPIMYPHIN
ELISKMHSLNISTFLVTNAQFPSAIENLIPVTQLYLSVDAASKESLKEIDRPLFRDFWQR
LMNSIDILRDKKQRTVYRLTLVNQYNMNEVSQYASLIKRGQPDFVEVKGVTYCGDSKNSK
ITMANVPWHADVVDFVQQLVFQLDDYEIAAEHEHSNCVLIAKLNFKINGQWYTWIDYEKF
FSLAERFKKDGISFTSYDYMAKTPDWALFGASQRGFDPEDQRWYRKSKDS
>A0A445H2S0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Glycine soja|TrEMBL
MSISISLSSVPARLTLLAVFSATTFYCLYKYHRLRHLKLFLNPNPNPNPKIIFVSETGTS
KTLARRLHGLLASNDVAFDLVDAQHYEPEDLPKETLIILVASTWLDGAPSAASRFFATWL
ADAAADFRAGSLLLSRCRFAVFGVGSRAYGDSFNAVARGLAKHLRALGAAEVVPLFEGDV
DGGDVDAVFDRWCEKVVAVLKSGSVVESCDNDGAEESGVVSSSEDESDVDSSEIVDLEDI
AGKAPSWRKAVANGEESNEKLNGRREMVTPVIRANLEKQGYKIIGSHSGVKLCRWTKAQL
RGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWQWQMDDPIEIVNS
AIDLHTNMIKQMKGVPGVTLERLSEGLSPRHCALSLVGEPIMYPGINALVDELHKRRIST
FLVTNAQFPEKIKSLKPVTQLYVSVDAATKDSLKAIDRPLFGDFWERFIDSLTALKEKHQ
RTVYRLTLVKGWNTADIDAYSKLFSLGEPDFVEIKGVTYCGS
>A0A671WMX7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sparus aurata|TrEMBL
MSIWHNRLYLYSAAALVFGIWFSLKVALKKKSFSKDVGTLVYRAVKNNDRDTVVHLSGVK
IFYGSQTGTAKGFAQELSEEVKTLGIPAEVIDMKDYDPDDQLADECSNKSVCVFLVATYT
DGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLW
MLSGMRVMTRGEGDCNVVKSRNGSVQADFLAWKVKFLNRLQALAKGEKKSCSGNCKTGGS
CKSKRRDTQEEEEEEEEKAALKNNGSEVKTEEQRERREMITPALRDALTKQGYKLIGSHS
GVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWR
WKMDPKHQNMIRQFRGVPGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHI
SSFLVTNAQFPQEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEK
RQRTVYRLTLVKAWNVEEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWHQE
VVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQTHEESG
GRQSFSALDYTAKTPSWALFGANEQGFDPADTRFQRRNKTKDISGC
>A0A0V1CPC9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichinella britovi|TrEMBL
MWKAYYNMYERTLHVFCPPDVITFNLCESVLIIVGISTALIVMLLYILMKKLAYSLHSRL
KSTFSTAVLDLQHYNPEGNLENEQAVCIFIVSTYVDGQCPEKCRWFFKWLEECVSDFRVE
KSVLSNVRFAVFGLGDKAYGSTFNKVAIKLSKHLLLLKANNILPLYLTEEDNFDHIQSDF
LKWSLQLIKYLEVREVSKFSSLHDNKRVSVWRDENENSSDAEDAENSANNVGDIEDIYFT
NVTNDSNKIKEMLTPTLRKSLTKQGYHLVGTHSGVKICRWTKSMLRGRGGCYKHTFYGIN
SHQCMEMTPSLACANKCVFCWRHHSNPVGTEWKWKTDPAEKILSDSLEGHKKMVRQFRGV
PGVKDARFEESSTVRHCALSLVGEPIMYPHINELISKMHSLNISTFLVTNAQFPSAIENL
IPVTQLYLSVDAASKESLKEIDRPLFRDFWQRLMNSIDILREKKQRTVYRLTLVNRYNMN
EVSQYAALINRGQPDFVEVKGVTYCGDSKDSKITMANVPWHADVVDFVQQLVFQLDDYEI
AAEHEHSNCVLIAKLNFKINGQWYTWIDYEKFFSLAERFKKDGISFTSYDYMAKTPDWAL
FGASQRGFDPEDQRWYRKSKGS
>A0A7J9P499|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVRKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFEAPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYIDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKDDWESILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLDMGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A7J9NZ80|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus maripaludis|TrEMBL
MIPDQIHNILRKQRYQIKEHSGVKLCGWVKKSFLEGKECYKSKFYGINTHRCVQSTPSVA
WCQQSCIFCWRVLPKDLGLDSFESPKWKEPEAVAEDILAMHKTVITGYKGILDRIGEEKY
LEATKPKHVALSLSGEPTMYPYLDELIEVFHKKGMSTFLVSNGILTDVIEKVNPTQLYIS
LDAYDLESYKKICGGTKEDWDSILNTLDILESKKRTCIRTTVIRNINDNILKFKELFERA
NSNFIELKSYMNVGYSRKRLNLDDMVKQVELLDMGKILSENSIFEIEDDSPESRVVLLTN
KNRKINPKIDFGF
>A0A7J6VBB5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thalictrum thalictroides|TrEMBL
MPLTNLKMTSNSSSSLPLRYTLLVLLSTSTLYCIWKSQRLRKARKLSLQNPNSNSSINRK
GKLLFVSQTGTSKTLANRLYNLLNLNNLSLDLIDSKDYEPEDFLKETLVLIIASTWENGK
PPESSNFFANWLAESAEDFRVGSLILSKCKFAVFGVGSRSYGENFNAVGKEFVVRLKELG
ADEVLNLGQGDVDGGDLDEVFDVWSQKLVRVLKGEVEENGGVYSNGVVSDSEYDSYVESD
DEDFEEKGSDAGMVDLEDIAGKGPSRKSSSVFTEVKKVANGVKEMVTPVIRASLQKQGYK
IIGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHSNP
VGKSWQWKMDDPLVIVNTAIDEHTKMIKQMKGVPGVKSEILLEGLSPRHCALSLVGEPIM
YPEINTLIDELHRRRISTFLVTNAQFPDKIRMLKPITQLYVSVDAATKESLKAIDRPLFG
DFWERFLDSLKALQEKDQRTVYRLTLVKGWNTEDVDAYASLFDIGKPDFIEIKGVTYCGS
SATSKLTMENVPWHYDVKSFSEAIAMKSNGVYEVACEHVHSCCVLLAKSDKFKVNGQWHT
WIDYEKFHDLVASGKPFNSKDYMTTTPSWAVYGANEGGFDPEQSRYRKERHHKGS
>A0A8C9Q1D9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Spermophilus dauricus|TrEMBL
PPLAAWDLSSPLLSLWMHRFYLYLGFAFGISLWICVQILIKKQGKSSQERSIPEAAQDLM
TNDYASLPKKHIFVSGVKIFYGSQTGTAKGFATILTKAVTSLDLPVAVINLKEYDPDDHL
VEEIASKSVCAFLVATYTDGRPTESAEWFCKWLQEASSDFRFGRTYLKGMRYAVFGLGNS
AYASHFNKVGKNVDKWLWMLGARRVLARGDGDCDAVRSKHGSIEADFRAWKTRFISRLQA
LQKGETSCGGNCRRGKCESKQHGTEDEEPEPHALAAQQPRDTEEEEPCESSSEEEFGAGE
HQGPNSVVDVEDLGKVMDLVKKEKREEEQQEEKGLFGSRGKKEGGEGRAMLTPALREALT
KQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEMILEGAVENHLDMMKQFRGVPGVKAERFEEGMKVKHCALSLV
GEPIMYPEINRFLQLLHQRKISSFLVTNAQFPEEIRKLKPVTQLYVSVDASTKDSLRKID
RPLFKDFWTRFLDSLKALAEKQQRTVYRLTLVKSWNVDELQAYAELVSLGSPDFIEVKGV
TYCGESAASSLTMANVPWHEEVVRFVRELVGLIPDYEIACEHEHSNCLLVAHRRFKIEGE
WWTWIDYGRFQELVQEYEDSGGSKAFSAEDYMARKNKSKDVSGC
>A0A0U5G2D9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus calidoustus|TrEMBL
MAESTASDGLLALWHSFRLPLLVALATGLAILRLRRVLQTRSKAATASSIPSSPRSLSPE
KKPRLDELTSTVEKKDTKALDSGRISPKPAVGPKRVTGKKPIKTAGRRTDAAPAEVEQPV
TFIQPIIFWASLTGSTERYAKVLLEDLRAAAQTKTDPENRERGLLPPQIYDLAEVDYDDY
FTTAPKPPSTSPGTRYVYLFLIPSYNIDTILDTFLAHLDETHHDFRIDTGSLSSLAGYAV
FGFGDKEGWPTEEEGFCSQAKELDRWMAKLSNKKRAYPLGFGDVKNDAQAALKEWTEGVQ
DILGDIVEHGSLGEGVPGSGDPLESDEEESDDEESDESKSKIRKGRKPQAVVDLEDIKMG
ADAQVGGSPIPVDFTIAGTSQGIQPTEKEMVPKTSPTYTSLTKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPD
LIFDGIKEGHYKKIKQMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINPFLDLLHS
EHISSFLVCNAQHPDQLETLNRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDIL
REKRHVQRTVFRLTLVKGFNIDDEVVGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTM
QNVPFYEEIQEFVLSLNKELERRGLDYGIAAEHAHSCCALLASRRFYVNGKWHSRIDYPR
FFELLEREKADGTTFRPEDYMMETAEWALWGNGGFDPNDERVYAKGKKKALKAAEPAAAA
EAEAEA
>A0A6A7KEP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermococcus sp. 101 C5|TrEMBL
MDVKPNMPEEIANLFKKQHYALIGHHSSVKLCHWLKESIKHDRFCYKQKFYGIQSHRCLQ
MTPVTAWCTHNCIFCWRPMEGFLGVELPQPWDEPSYIVEKSIEAQRKLLSGYWGVKDQIN
AKKLEEAMEPKHAAISLSGEPMLYPMIGDLVEEFHRRGFTTFIVTNGTEPEVLEKMIERN
TLPTQLYVSLTAPDEETYQKVNVPMIPDGWERINRTLELMRDLPVRTVIRLTLVKGENMH
NPEGYANLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPSHKDIKAFAEELVKYLPGYHIE
DEYPPSRVVLIMRDNVSKEDRFIKH
>A0A5E8C146|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Saprochaete ingens|TrEMBL
MDAWHFARPFVLTTVVVFGIFKYWELSTFSITSEEQPPSLKPDKKASNYNTQKSVDKDFI
NNNDKGNIPVVKSYPLAIDFTTTENQVSQERKIKTKKAPKVFSAKKSIAVSRKLGKLNSE
LSPPSLNSPVYIFYSTLTGTSEKIANLAIEKISLVLSNPPVLLNIDYIDDLDKYFVSPTI
KDFHFPPIYLFIVPSYETESPLDYFIESLKETYNDFRVDSRTLSLIAGFSVFGIGDQESW
PESSKYCYQGKIIDKWLSKLGAPRLFPLGMGCVKTNLDQEFDVWLQHLISTLKDEIVLSE
PNSIADSDSESESESEDIESLESSSNATLVDVEDIGPSIEATANSRSQDSSLIKEMVGKS
TPTFNALTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKYSFYGIKSHLCMETTPSLACS
SKCVFCWRHGTNPVGTTWRWQVDSPEVIFKGALEGHYKKIKQMKGVPGVVASRFAEAFQV
RHCALSLVGEPIFYPYINDFVDLLHSQRISSFLVCNAQHPDELSRLKRVTQLYVSVDASN
EENLKKVDRPLHRDFWTRFLKCLDILREKKEQRTVFRLTLVSGYNMSDYDEYAKLIARGE
PCFVEIKGATFCGTSKTSSLTMKNIPFYQEVKDFVENLNAALGRLGLEYGIAAEHAHSCC
ILIAQNRFKVDGVWHTVIDYDKFFNLLEAGKDFGPMDYIAPTQSWAIYGSEEGGFSPNDL
RFVKKK
>A0A2U1S705|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobrevibacter woesei|TrEMBL
MSLTKEAQKKLEYSGYRFVGQHGHAAAKICHWTKQSILDKGVCYKEKFYGVKSHRCLQMS
PAVPYCQQECEFCWRDLSYTKTEWEGEYDDPKTIIDEAIKAQNNLLCGFFGNDKANREKL
EESKTPTNAAISLAGEPTLYPEIDELIAEFNRRDFTTFLVSNGQYVEKLKNLETEPYQLY
LSLDAPSKKIYDDVCNPQINDGWINLNESLETLASFNSRTCIRTTCVKGKNMENPEEYGN
LIKKADPTFVEIKAYMCVGSSRERLTLDNMPSFDEVKEFARKIGEHCGKEIVNESEISRV
VLLQ
>A0A7S9KM27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Epichloe festucae (strain Fl1)|TrEMBL
MAGVCQKTDPLQGLFKGYSGVKFDDVVELWHENRTPLILCALVLLAAIRVYIRNKVELEP
LKARPKESQSTIVTEDTKRRSNAVITGGINTAGPDGPRRIKGGMVKKPVAENKAYHDKSR
PVKVLIFFSSVTTKTEKIAKQFLATLSRSAAQLSQDTGRRVLKPEVHDLADIDFEDFFVS
PAKSAENAYLFYLFLLPSYNIDTINDTLLQHLEETHHDFRIDTAPLASLLGYSVFGFGDK
EGWPDESEGYCFQAKELDRWMSKLTARKRAYPVGMGDMRGNHVERFDEWALGIQEVIAHV
ARNGSLGEGVPGSGDAVESDAEDVADEDDGEVLFEDDASGGEKESSRPLDDVEDLGRMLR
TSANKPSTNSKKAPLAVDFTSYGSSTKKRTQVAPVIKEMVAKNSPTYAALTKQGYSIVGS
HSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTT
WRWVVDPPEMIFEGVKEGHYKKIRMLRGVPGVRAERYAEALKIRHCALSLVGEPIFYPHI
NEFLAMLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKDSLRKIDRPLHRDFWE
RFQTCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGLPCFVEVKGVTYCGTS
TSSDAGLSMSNVPFYWEVCEFVNALDKRLKDKGLKYGIAAEHAHSCCILLASERFSVNGR
WHTHIDYTKFFELLEERGPDGDWTPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKIEN
VVVREAPPPDSW
>A0A2I0PDR8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanomicrobiales archaeon HGW-Methanomicrobiales-3|TrEMBL
MPSTQCDPLRRQGYQFFSPASTAALKPCMWCKRALQGGEMCYKHQFYGIDSHRCVQMTPT
LRCNQRCLFCWRSFEHEPQEDVECPPETILAGLHKYQKKALAGYNAVLDNTVTDERWQEA
IDPKHIAISLSGEPTLYSQLPELIDRLHDNGYTTFLVSNGTNPEMLRRCNPLQMYISLDA
PDRETYHAICRPQENYWDRIQESLRLLGTRRSAIRITLVKGLNDFAPEQYAAILQESGAT
FVEIKGYMYLGYSRNRLARENMPEHAEVRAFAEKVEAACDYRFKDENKLSRVVVLEHMT
>A0A4V1J5I0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dimargaris cristalligena|TrEMBL
MSCSAGDSPLQSEHCNLVPETAWYQSPWATGALTLAIASYFVYHQIRHTIRVTRKTAAKT
QETTPTTTSPRNIVPTTLPKEKCAASPDSPTSESPACCRGAASPTACQCPSSALKDPATR
EAILSTYYHEAPLKIFTGGQTGTAQKFSQLLKEQLASAGKIPAVIQDIAEYDTESFFTEK
AVCVFLLATYNVENPTEWFLKWLEDAKYDFRLGNECLAHLRFAVFGLGDSAYGDEFGIAG
RNTDRWLGSLGARRMYPLGEGDKNEDQLASFEAWTQGLLSTLLDPEAYTAPIEADARISD
AEDEDENEEDTTPDNKDVLGGSDGEMVDLEDMGGVARRIQEAREQRRDDEASFAASQTSR
VTKRPYRPIGEGAEARPVRAPRAMVSPMIHQNLTKQGYKVIGSHSGVKICRWTKAALRGR
GFCYKHSFYGIQSHLCMETTPSLACANKCVFCWRHHTNPVGTEWRWQMDDPGFILEGALQ
NHYQMIKQLKGVPGVKADRFQEAFQVKHCALSLVGEPIMYPRINEFIRMLHEQNISSFLV
TNAQFPDAIADLDPVTQLYVSVDASTKESLKKVDRPLFRDFWERFLDSLDALRAKGQRTV
YRLTLVKDYNTEELANYVELIQRGRPEFIEIKGVTFCGFSGASNLSMQNVPYHNEVVHFV
QKLVSLLGDEYGIACEHAHSCSILVAHTKFHREGRWHTWIDYAKFQQLVKSGASFNSLDF
TAPTPDWAVFGNEHHGFDPSDTRFYRKKGGKSSG
>A0A6P5TGK1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Prunus avium|TrEMBL
MPLSSVPARLTLLALLSATTFYCFYKSRRLKQLKLSLNPNPSSSPRKGKLFFISQTGTSK
ALAHRLLDLLTSNGLAFDLVDPNHYEPEDLPKETLVLIIASTWDDGKPPANAKFFSNWLA
ESAEDFRVGSLLLSNCKFAVFGVGSRAYGATFNAVGKDVAKRMRALGAYEIFSIWEGDVD
GGDIDEVFEAWSGKVLRFLKGGVAENGGVLSNGVGAECEAESFDGSDEDDEEEDDVESEV
VDLEDIAGKGPSRRRTVTVTKTNGTVNGQKEMVTPVIRASLVKQGYKIIGSHSGVKICRW
TKSQLRGRGGCYKHSFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGKSWQWKMDDPL
EIVNSAIDQHTKMIKQMKGVPGVTLERLTEGLSPRHCALSLVGEPIMYPEINALVDELHR
RRISTFLVTNAQFPEKIKMLKPITQLYVSVDAATKESLKAIDRPLFGDFWERFIDSLKSL
KEKQQRTVYRLTLVKGWNTEDIDAYYNIFSIGNPDFVEIKGVTYCGSSATSKLTMENVPW
HADVKAFSEALALKSNGEYEVACEHVHSCCVLLAKTDKFKINGQWFTWIDYEKFHDLVSS
GRPFDSKDYMAATPSWAVYGAEEGGFDPYQSRYKKERHHRSNQ
>A0A4U5JIG6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronomonas salsuginis|TrEMBL
MPKQVDDPDYHSENHTAAQTCGWTANALRGEGRCYKNHFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELGDVEWDDPEAVADASIELQRTLLSGFGGNEKVPERAFEEAMKPRHV
AISLDGEPTLYPYLPELIDAFHDRGITTFLVSNGTRPSVLEQCDPTQLYVSVDAADRQTF
KDVVKPVEENAWERLIETLDVLAEKDDTRTVLRTTLLSGHNMHHPEWFAAMFDRADADFV
ELKAYMHVGNSRGRLDRDVMPDHEDVVAFTEAVREFLPTHPFVRDVEASRVALLARDEDT
MVPELKGGSDFWRQEPYAES
>A0A833E8W4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrodictium delaneyi|TrEMBL
MDFRPRTVRNKRWKYRISDFPEPYRSLYRILERQGYIIVGRHSVVKKCHWTHAALVENRF
CYKCKFYGIESHRDIQMSPAALWCWNACLHCWRLRPTDTIRWDDTKLPWVDDPELIAEGS
IEAHRESLMGYWGHPKADEEMKRLLEEAMNPVHVAISLTGEPTLYPRLGELIQEYHKRGL
TTFLVTRGVRPDVLANLEEEPTQLYISLEAWDKKSYNEFDKPLVPRAWELTLETLEMLPS
FSSMTVIRFTLVRSFNMHETALKAWAKLVEIAQPTYIEFKSYMHVGAARHRLSSKDMLRH
IEVLAFAKKFADMTGYEILSQQVESRVVLLSRIDKPVRVGKGCKDEIDRERGKLEEMLDM
LKTDSSLDEVEYKMVLEQKI
>A0A0D1ZFX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Exophiala mesophila|TrEMBL
MDLGDGGAMPVILADWLDRGLTVWHESRVILTAVLVVCFLTILVQRRRSTRPFTQSSSPA
LEKADALQGSQIEKLSISETYDVDNKTTLAAAPTQKVKTRPAAARIVTGRKPASTARNGN
LNQVQEEVTHIQPLIFFSSLTGTTERLSKIASESLQALSTRNTSILQPEVHDLSYVDLDD
YFISGPKTPSPRDGTVFFYLLLIPSYDIDTILNTLTAHLDETHNDFRIDTSPLAVLAGYT
VFGIGDKSGWPSEEQGFCSQAIEVDKWMAKLTGRKRAYPLGLGDVKDNATHALREWTDGV
STVLEELISTGSLGEGVPGSGDAIESESEEEPEMVDEEEEFPDSGRNKRRKIANTTDLED
VGGKTKTKNSSLAVDFTTYSSIQVTQPVLKAMVPKESPTYASLTKQGYTIVGTHSGVKIC
RWTKSALRGRGSCYKNSFYGIASHLCMETTPSLSCSNKCVFCWRHGTNPVSTTWRWQVDD
PNLIFEGAKEGHYKKIKMMRGVPGVRSDRFEEAMRIRHCALSLVGEPIFYPHINKFLDLL
HGERISSFLVCNAQHPQQLQDVKRVTQLYVSIDASNKESLRKIDRPLHRDFWERFQACLD
ILREKRFVQRTVFRLTLVKGFNIEDEVEGYVNLVAKGLPCFIEVKGVTYCGTSTSTNAGL
TMQNVPFYEEVAAFVEALNVALAKRGLEYGIAAEHAHSCCILLASNRFHINGKWHTVIDY
DKFFQLLESGQDFRPEDYCKETVEWALWGNGGFDPRDEKVDRKGRPKEASTVTGKKIDSS
KLDF
>A0A1S3H4E9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lingula unguis|TrEMBL
MDEGTFLADLAAVIAQSWLLILLGFLGLAWLTFQQRKTYVPGKPKRRLSVQASKNSDERN
LNKTKSSKKETCVKIFFGTQTGTAKTFADIIKKEASEHSTKCEVIDLKTYDPEDNITDET
DGKNICVFIISTYTEGSPPDDAAWFYKWLEEAASDFRIQKTMLQDMRYCVVGLGNSLYKE
RYNKVARNIDHWFHKLSANRVLGIGLLDENVASSKNGGIEADFEFWKNRFWSMVLGSPQN
KKDVKPNCGTADGDTKEMYETSSEEDTEDEEEEGDGDGEKVQKANGVVDVEDIGKMVNNI
KKAKAKRKVEDDNKSKEPREMITPLLKTSLQKQGYRLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDDPELILEGALQNHC
NMIKQFKGVPGVKSDRFTEGLTPKHCALSLVGEPIMYPEINKFAEMLHSKGISSFLVTNA
QFPDAIRNLTPVTQLYVSVDASTKESLKKIDRPLFRDYWERFLDSLKALSEKGQRTVYRL
TLVKNYNTEDIENYASLVSIGKPDFIEIKGVTYCGESKASRLTMDNVPWHEEVIKFVQDV
VDRLPDYAIASEHEHSNCVLVANKKFQVNGDWWTWIDYDRFHELVQMYKASEGQKTFSAA
DYMAQTPHWAVFGADERGFDPGETRFMRKKTKDISGC
>A0A1S7HDV8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Zygosaccharomyces parabailii|TrEMBL
MTFFFPFSLQKFRAHRTRRHKSQDFVISLHFFNRLISEEFIRLALSLMIRLNGATAAGTF
LLTMVYLWLGGRVTIALAIIVSYAILHKEYNVSNEQGQEKTPAKTEKKEKKHTCCGGKGG
ANCCSSKAGGAGGSGHACRCSSKNKAQEKKEEAKEEKKGLEAGSFPVAVDFTQAFKPQKK
KSTKQPKVFSKPMPTKKKTASRDDDFKKSAMTVSNGTLLNSQIYVFYCTLQGTAERYANR
VMAQLCTMRDLKHRPTLINLDEVTDLDDYFVSVPSENSLYILVLPSYDTDCPLDFFLQTL
EENFNDFRIDKYPLRKLVGYSILGIGDTETWPEKFCYQAKKTDHWIARLGGRRIFPIGEV
CVKTGGEPKVNEWIDLFCETMKDDEPILYEYDESVEDDGTENDEMVDLEDIGNAEGNNST
EIKQMVAKDSPTYKTLTKQGYSVVGSHSGVKICRWTKSDLRGRGSCYKHSLFNIVSSRCM
ELTPSLACSSKCVFCWRHGSNPVSKNWRWEVDEPDYILENALKSHYSKIKQMRGVPGVVA
ERFAKAFQVRHCALSLVGEPIMYPYINRFIGLLHEKGISSFLVCNAQHPEALANICRVTQ
LYVSIDASTKGELKKIDRPLYKDFWERMLQCLDILNTTQSHQRTVFRLTLVKGFNMGEVM
SYADLVQRGKPCFIEVKGATFAGSSDGNGNPLTMQNIPFYEEIKTFVKKFAAELQRRGLG
YDVSAEHAHSNCVLIASTKFKMNDEWYTHIDFDKFFDLLASGQDFTPLDYVAKTPEWALF
GNGGFAPGDTRFYRKGKKKIPETEKLSSTYSAAFVNSTQQEPVRGETAASFEIA
>A0A1J9R2J9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Diplodia corticola|TrEMBL
MASNDSFQMASSDLLSLWHTSRVPVLLTVCAVIAFARLFQHLRQPRQKLSASPIPGSPTS
KIDEIAAPWAKTENIPSIAEKATVPVDDGHVEEITIAERPLVRPKAGPKKVTGTKLPRQA
AKRTCSFDAARDRVQPLVFFSSLGGTTEAAAKKVVEEINQWIYALDSESIPRPLNPQVLD
LAELDYDDYFISAPKGDENVKYFYLVLIPTYNIDTMLDNFLEHLQETHHDFRIDTAPLSG
ILGYAVFGFGDREGWSTEEEGFCSQGKDVDKWLAKLTAKKRAYPLGIGDVKSDAQERLKE
WRLGVQDILLDVCAGKGLGEGVAGSGDAMESDEEDVDDDELDSETTQPLKPKKTKAKSSL
DDVEDLGKMVKSEIDPDEPMEVDFTTYKKPVKAAAPAAPKEMVPKSSPTYSSLTKQGYTI
VGSHSGVKICRWTKSALRGRGSCYKFSFYGIRSHLCMETTPSLSCSNKCVFCWRHGTNPV
GTTWRWVVDPPEKIFEGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFY
PHINEFMAMLHKERISSFLVCNAQHPAQLATLKQVTQLYVSIDASNKESLRKVDRPLNRD
FWERFCACLDILREKRFQHRTVFRLTLVKGFNMADEIVGYADLVERGLPCFVEIKGVTYC
GTATSAAAGLTMQNVPFYAEVQEFVEALNKELNDRGLEYGIAAEHAHSCCVLLASTRFRK
QVDGEWKWCTLIDYDRFFQLLESGEDFKPEDYMGEPTPEWALWGNGGFNPEDERVYRKGK
NKDKAIEEAPKPMVEI
>A0A2A5QXH7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrinema ejinorense|TrEMBL
MSDSANPGRDGAGPDTTTDAADGDGSEAAQVSSPDYHSENHTAAQTCGWTANAMRGEGKC
YKNIFYGIESHRCIQMTPVVRCNERCVFCWRDHQGHSYEMDDVEWDDPEAVVDASIDLQK
KLLSGFGGNEEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNG
TRPEVLRECDPTQLYVSVDAPERHTFDQVVGAMEDDAWENLLETMHVLAEKDDTRTVLRT
TLVKGENMHNPDWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSAMPDHDEVVEFAEDVR
EHMPGFEEVMGVPASRVALLSKTKDTWVPKLQKGSEFWERDPVTGD
>A0A3B6KML2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Triticum aestivum|TrEMBL
MPPSPAAAAASGTSHLALLLLLSSSSLFFLYKSIALRRLRRTLRPSPSPSSSSPAAAAAA
PTLLYASATGTSKALAERLSARLADAGLPARATDAAAFDPDDLPSVPLLLLVLPTHDAGA
PPPGAAFLARWLAETAADFRAGALLLSGLRFAVFGVGSRAYGDTFNAAARSFSRWLRALG
AVEVLPVGEGDVDEGDLDDVFEEWCGRVLRVVKGEEVEDDAVDGETNGFDGLEGEESDYD
DDDDEEEEEEVASGEVDMEDIAGKATAKKQNGKVESALPNGGQNGARAMVTPIIRASLEK
QGYKIVGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRH
HTNPVGKSWKWKMDDPLDIVNTAIDEHRKMVKQMKGVPGVKPERLAEGLSPRHCALSLVG
EPIMYPEINTLVDDLHRRHISTFLVTNAQFPEKIKALKPITQLYVSVDAATKESLKAVDR
PLFSDFWERLLDSLKSLHDKDQRTVYRLTLVKGWNVEEIDAYANLLKLGQPDFIEIKGVT
YCGSSATSKLTMENVPWHADVKEFSEVLASKSGGIYELACEHVHSCCVLLAKVDKFKING
KWHTWIDYDRFNELVTSGKPFKSSDYMAVTPSWAVYGADEGGFDPDQARFKKERRHGAAA
LKG
>A0A2U4A8Q6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tursiops truncatus|TrEMBL
MDPSLDMWDFSSLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSQEKTVPKASRDL
MTNGYISLQKKEVFVSGVKIFYGSQTGTAKGFATVLAEAVSSLGLPVALINLKEYDPDDH
LVEEVTSKNVSAFLVATYTDGRPTESAEWFCRWLEEAANDFRFGKTYLKGVRYAVFGLGN
SAYVSHFNKVGKDVDKWLWMLGAHRVMSRGEGDCNVVKSKHGSIEADFTAWKARFISRLQ
ALCKGERKPCGGNCKKGKCESNQHGSEAMEPGSHAQEGFHQRDAEQEEPFGSTSEEESGT
EDHQSLKSVIDVEDLGKIMDRMKKEKREKERQEGETSLIRSTVKNEASERRAMITPALRE
ALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVF
CWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMMKQFRGVPGVREERFEEGMTVKHCAL
SLVGEPIMYPEINRFLKLLHERKISSFLVTNAQFPAEIRNLKPVTQLYVSVDASTKESLK
KIDRPLFKDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAKLVSLGNPDFIEV
KGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIAHKKR
>A0A8C2Z9N1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyclopterus lumpus|TrEMBL
VSQNALSPSESYLMSVWHNRLYLYSAAALVFGIWFSVKVALKKVNFSFVQGFAEELSEEV
KTLGVPAKVIDIRDYDPDDQLADECTNKSVCVFLVATYTDGQPTENAEWFCKWLEEASTD
FRYGKTYLKGLPYAVFGLGNSVYVGHYNTVGTNVDKWLWMLSAVRIMTRGEGDCDVVKSR
HGSIQADFLAWKVKFLIRLQALVKGEKKSYSGNCKTKGSCKNPKKDGQEEEEETTALQNS
SEDELVESSSDEEESGLQDEEKSGSVVDMEDLGNIMSSAKRAKVFTALLTCFVLSFPAGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTN
PVGTEWRWKMDPAEKILHEAMEKHQGMIRQFRGVPGVQPERYEEGLAVKHCALSLVGEPI
MYPEINAFICLLHSHRISSFLVTNAQFPQEIRNLVPVTQLYVSVDASTRDSLKKIDRPLF
KDFWPRFLDSLRALGEKRQRTVYRLTLVKAWNVEEMLSYSELIALGQPDFIEVKGVTYCG
ESAASTLTMANVPWHQEVVAFVQQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTW
IDYERFQDLVQVQGESGGQRGFSALDYMAKTPSWALFGANEQGFDPTDTRFQRRNKTKDI
SGC
>A0A7K4YRS0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bucorvus abyssinicus|TrEMBL
LDVSMDTWNFISTCLVSLWLHRSYIYSAVAFGITVWIVIQFTTTRTKRKITEQVRTENKL
VNGYATLQAKEVCVAGVKIFYGSQTGTAKRFAKGLAEAVVFLNLPVEVISMGDYDPDDRL
LEETTSRNVCVFLVATYTDGQPAESAAWFCKWLEEAANDFRFGKSFLKGLRYAVFGLGNS
VYVDHYNTVGRNTDRWLWMLGARRIMTRAEGDCNVAQSKHGSIEADFEAWKAKFLSRLQG
LCRGEKKPCSGKCRKGKCKSSGKQSKESSDHEHGTSQYENTKTEELFETTSEEEADAEEA
GGTNSVIDVEDLGSIMSHMKKAKVLLLRLMLNFVYQLVCFVYQLLQVKISCLFFGLFPGY
KLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWRHHTN
PVGTEWQWKMDQPERILQEAIENHQSMIKQFKGVSGVKADRFEEAMTAKHCALSLVGEPI
MYPEINRFVKLLHQHSISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLF
KDFWQRFLDSLKALSEKQQRTVYRLTLVKAWNVDELKAYADLIALGKPDFIEVKGVTYCG
ESSASNLTMANVPWHEEVVRFVQELADLIPNYEIACEHEHSNCLLIAHKKFKINGEWFTW
IDYDRFQELVREHERSGGSTTFTAADYTARTPHWALFGSRERGFDPLDVRYQRKNKARDI
SGC
>A0A532T3J2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Woesearchaeota archaeon B3_Woes|TrEMBL
MSSDIKKKDLKKQGYRLVGNHSAVKVCGWTRKSLRGEDVCYKEKFYDTKCHLCVQMTPAL
NTCTHRCVWCWRDIDFTNPRWSGKVDDPKFIVDGCIKEFIASLEGYHGYKKVDKKKLKET
NKPQQFAISLSGEPTMYPKLPELILELKKRKINSFLVTNGTNPSMLKKLIEKKAQPTQVY
ITLPAPDEETYVRVCNPLIKDGWKKILQSLELVSKFKRNIFRLTLTKDINMDKVEEYALL
IKKYKPKKIECKSYMWVGYSRERLEIQNMPYHNEVKKFAQKLAKLTGYKIIDEKKESRVV
LLSKD
>A0A1A8VUW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium ovale curtisi|TrEMBL
MANGMMEEKRLEHYPPLRPFQMLSIRKKAKINFKVIYGSESGGTYKRAKEFLNELVEFFR
EIGSFFKDINRISLCGDNADGGSTNGCLIDTSELGSRLVAYFKSYLMEKEKNKAGLSRES
RGKRSRGRMTNGETQHLDIFKNGETESNEHFANCVDIFIENSISTVHIDFTSGNEFDSYS
FFENSQEYDLNILLLLLSTCNYGSFPKNCYKIEEILRDLLNDFRVGKNYLENVFYSCVGF
GNKQYGSKHFCAPIKECDKILTSLGAHKLYKTVKLCDEEDNDVTLLEWKSSLFKTLSLSL
FFYHFDFTKLRSNYVQYAMKKVYNSLKYYCSFFCEKDERDSNGHGEKVLSEVDVSFREES
DGAISPNVHVDENKKETIPTNATDEIDSKRRETFNCGSGDEVEDILFDTPKDMLSINQRE
KLTKEGYKIIGSHSAVKLCRWTKSQLRGRGGCYKHTFYGINSYQCMETTPSLACANKCVF
CWRHHKNPVGTQWKWHKDDANMIVEEAIKKHRGMIKELKGVYGIIKERYDNAMNVKHCAL
SLVGEPIMYPDINQLIDELHKRNISTFLVTNAQFPSELKKLHKVTQLYISIDGPNRDALK
NIDRPLFKDFWERYIKCIKLLKKRKERTVFRFTLVKEYNMMSDEILSYAKLVEYGLPDFI
EIKAVTYCGSSEGYKLTMKNIPWHEEVYNFAHHLINCKSSITDAYDIACEHKHSCSILIA
KKIFKINNKWHTWINYENFQLLVKQGKDFTSTDYCAETPHWAVVGAQECGFNPSDKRVYT
KGRNKNRNPDETQRDSPVVVAPT
>A0A087S4G3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Marine Group I thaumarchaeote SCGC AAA799-D07|TrEMBL
MSCSGEIIEKEPELIQIKSSIVKQLKKAKYGVADHSTVGLCHWTKKSFKNEGTCYKHKFY
GISTHSCMEFSPAGMYCENRCIYCWRPMEFYESMEMQPQNVAEPEEIMIKLMAERKKLIM
GHYGDPSQDRKKLDESLLPNHYAISLSGEPTMYPKLPELIKYLKSLDATKSIFLVTNGQE
PDMIQELQDKDALPTQLYLSTNAADYQSFLKINRPRYDDSWERWNRTLKMLSTLDTRTVL
RITLIRGYNDNEEMIPVFASLLRESNAHFVEIKSYMHIGRSINRLEYSDMLEMDEIRRFA
NKLAQENNAFVVMDESEISRIVILQNKKRFVDRFISTYC
>Q6KZS1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)|TrEMBL
MRTKITLNIFIKFICVINNYKLIYKKQHYGLVGKHSAVKVCHWTKSELTGKASCYKNTFY
GINSSQCIQMTPALNSCTENCEFCWRFQGFDSMHIGDEDDPEFILEESIKAHLKLISGFK
GNPNVSSEAWEKAMHPKHMAISLTGEPTLYTRLGELIEAATKRGISTFLVTNGTLPMVLE
KLDPLPTQLYVTVAGPTKEIFNRVLNPAIGNAWENFNKTLELLPSLDTRKVIRHTLVKDV
NMPYYDEYEKLDRKADPDFIESKGYVHVGQSIDRLTADNMPSHEMVLEFSNEMARRLGYT
PYADRRESRVAMIAKDPSKARIDFDSVLKKAMEKIS
>A0A401NX14|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Scyliorhinus torazame|TrEMBL
MREIVSLVLLCLCRPVCGDERSDDQIFDTWNSLQNYALSLWHLRHYVYSTIVVALGVWVA
VEFLSKIHNKPKEDNIVLKVAKEVIQNGHLAQEEKEVHVAGVKIFFGSQTGTAERFATIL
ADAVQKHGLPVEVVDLKEYDPDENLVDEVYSKTICVFMVSTYTDGQPNKSAAWFCKWLED
ATHDFRYGKTYLKGLRYAVFGLGNSVYVNHYNTVGKNIDMWLWMLSASRIMTRGEGDCNV
VKSKHGSIEADFSEWQTTFLSRLQALCKEEKNECSSNCKKGKCKSKVEKHNEESSQNEEV
PEEIKDYSSEEEELFETTSEEESGLEDETEAASVIDLEDLGNVMNNMKQAKEERAAAKKA
VRRKASKYAIGIKEIAEPREMITPALRNALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGC
YKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDEADTILKEAIDNHQ
NLIKQFKGVPGVQAERFAEGMMVKHCALSLVGEPIMYPKINQLVKLLHHKKISTFLVTNA
QFPEEIRKLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLESLKALADKKQRTVYRL
TLVKAWNVDELRSYADLIEIGKPDFIEVKGVTYCGESSASNLTMANVPWHEEVVYFVQQL
ADLLTDYEIACEHEHSNCILIAHKKFKVNGEWWTWIDYDHFQDLIKDYEENNGTKIISAE
DYMAKTPTWALFGAKQRGFDPVDTRFLRKKKKDISGC
>A0A1V4UA50|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon PtaB.Bin056|TrEMBL
MCYKHQFYGISSHRCVQMTPTLRCNQRCLFCWRSFEHEYPGERDLLPGEILARVAALQKK
ALSGYKPSPYVTPERFAEALDPKHVAISLSGEPTLYPHLPELIDLFSREGFSTFLVTNGT
RPDVVARCRPFQTYVSLTAPDAGTYRKVCRPLEDTWEAVQESLSLLGTRRSAIRITLVKG
HNDFSPGAYARMIQDSGATFVEVKGYMFLGYSRKRLERGNMPSFAHVKEFAENIAAACDY
EVRDENPASRVVCMGRVQ
>A0A370BQZ4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus niger ATCC 13496|TrEMBL
MASSSELGHMEDLPTGGYKSIQPFQLKRPVVSEIVWDFFSISQASHIWDTMKERYSSTRT
PLYIGSLSPGTLVNNCQNILEVPPPPPLPPRTPPPPPSPATSSTSNSPNHSPPPPPPPPP
PNTRRRHTSSHYKQRGRHLTCRFAPEAPRDACPIGQFSAGTNQRPRRWSQKIPRKSRGTE
SERTSTDPRTSIDSTLTRRVWAAFVSLCLVLATCIRPSTDSVGYCDVSPGLRQPLSSSSP
SAPRPLYLARLFESFRGDKGSQIPPLSHGSRLFFSIYLRWRDLETKVIMLSLCDRASTNG
SFCLGLLAFWHSYRLPVLLALATLLVLVRAYRKLQPKSKIATASSIPSSPRSHSPEKREK
TFSNSTEKDVGTDSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPAVSFIQPI
IFFASLTANTERYAQVLLEELRAAARDRADPDNRERGLLPPQIHDLSYVDFDDYFISAPK
PPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYSVFGFGDK
EGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDAESALKEWSRGLQDILGEI
VENGGLGEGVPGSGDPLESDEEDLDDEGSESDKANGRKRNKNQSVVDLEDIKFSSDAASG
SPIPVDFTTGGKSPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGR
GSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGVKE
GHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSFLV
CNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHYQR
TVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTYCGTSTSAGAGLTMQNVPFYEE
VQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRFFQLLEKE
KADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKAIQAAAATEAQG
>E8R881|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Desulfurococcus mucosus (strain ATCC 35584 / DSM 2162 / JCM 9187 / O7/1)|TrEMBL
MSIEWSEVKRRREEFWNSSPVYRAIYDRLVKQGYHLIGTIGAVKRCHWSKEAVLRNRYCY
KCLWYGIESHRCIQMTPVAAWCWNRCLHCWRLQPEDIGMHWDDTRPPVVDDPEVLVEESI
RVHREIMAGFKGNPRADQRLVEEALNPKHAAISLTGEPLLYPRLGELIEEYHRRGITTFL
VTHGTRPDVLGSLEVEPSQLYISIEAWDKDSYEHFNRPLVPRAWELFNETLGLIPSFKSP
TVFRFTIVKGFNDHDVALRSFAGFVEKAQPSYIEVKAYMHIGGSRGRLFKNNMPSHGEVR
NVAARLAELTGYQVLSESIPSRIVLLSRVGKPLRHGKGCPDGVEHPEKYAPPLTEEYEEL
QD
>A0A1G8WTX3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoculleus thermophilus|TrEMBL
MHSEACKALKRQGYQFVSPASSAAVKPCMWNKRALKGGEMCYKAQFYGIESHRCVQMTPT
LKCNQHCLFCWRSFEHEVVEDEECPPEAIIANLRRLQKKALSGYKVSPYVAPERFAEALA
PTMVAISLSGEPTCYSRLAELIDGLNAEGYTTFLVSNGTRPDVLSRCRPYQTYVSLDAPD
RETYLSLCRPREDYWDHILESLAGLAGRRSAIRTTVVRGYNDFSPERYAAIYQDSGARFI
EVKGYMHLGYSRNRLERDRMPEHHEIRAFAEKITEHCDYTIKDESPASRVVCLERKI
>A0A2T0FE16|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Wickerhamiella sorbophila|TrEMBL
MGLWTSIRVFVLLACLLTAFLELARRKEENRAKLNEPKKKVPEKERIMAVDFTTPASTIK
KPRKVVKPKTQKTKAIGESASTSSRMTIFYSTLTGSSERYAQKLHNQFKHVMENEPDLLN
LDYVDDIDEFFLSPKTPGAIYILVLPSYETECPLDYFIDSLKETYNDFRIDSRPLSSLAG
FSVFGIGDSESWGQEDKFCYQAKLVDKYLGKLGARRVFPLGTGCIKTTIDESFDEYIEHL
TSELHNPTPASELADIADSDDEGEDDPSVMDVEDMGKPMRVKELAEAKQMVAKDSPTYKA
LTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLSCSNKCVFC
WRHGTNPVGTTWRWQVDPPKAILDGALEGHYKKIKMMKGVPGVQAARFAEAFTVRHCALS
LVGEPIFYPHINEFLEMLHAKHISSFLVCNAQHPTELAALKRVTQLYVSIDSSDKESLRK
VDRPLYRDFWERLEACLDIIREKRTHRTVYRLTLVKNFNAEDVEGYADLIARGEPCFVEV
KGMTYCGTSKNSVLSMENVPYYEEVQAFVEALETELQSRGLEYGLATEHAHSCCVLLAQK
RFYINEKWYTHIDYAKFFELLESGTDFGPMDYIAETPSWAYYGSEEAGFNPVDVKHRRGK
PVE
>A0A6J2VK17|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chanos chanos|TrEMBL
MQGTVENIRGFADGYFLLVWQNRLYLYTAAAVLIGLWLTLSMAFKKKKLVSVVPWLYKTT
KKNEYPPEKEKVVHVAGVKIFFGSQTGTAKGFAKELAEDVRSLGFQSEIIDMKDYDPDDR
LSEECTNKMVCVFLMATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLRYAVFGLGN
SVYVGHYNTVSKNVDKWLWMLSGSRIMTRGEGDCNVVKSRNGSIQADFQAWKAKFLSRLQ
ALAKGEKKACSGKCKNGSCKNKKKHKEEADDNHSQPEKNSSEAELIESSSEEESAAEEDT
GHGSVIDMEDLGNVMNSMKKAKRKMEGEEEESHRVRVSKLNGVKKTEMEEERREMITPAL
REALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
VFCWRHHTNPVGTEWRWKMDPAEKILQEAVENHQSMIRQFRGVPGVRPERFEEGLIVKHC
ALSLVGEPIMYPEINSFLKLLHQKHISSFLVTNAQFPEEIRNLVPVTQLYVSVDASTKDS
LKRIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTLVKAWNVDELKAYAELIALGQPDFI
EVKGVTYCGESSASNLTMANVPWHEEVIYFVQQLADLLPEYEIACEHEHSNCLLLAHYKF
KVDGEWWTWIDYPRFQELIQEYEESGGTKTFSAQDYMAKTPSWAVFGAKERGFDPLDTRW
QRKNKTKDISGC
>A0A1V4Z3R5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanobacterium sp. PtaU1.Bin242|TrEMBL
MPLKTNQQKDLEKKGYRFVGSRKHAAAKICHWTKKSILNEGVCYKEKFYGIKSHRCLQMS
PSISFCHHKCLFCWRDVSITKTQWDEEFDEPADIIDGCIEAQKNLLCGFFGNSQADPEKL
AECKDPNNAAISLAGEPMLYPLINDLLAEFKKRDFTTFLVSNGMTPSRLENLDPEPTQLY
LSLDAPNPQIYKQLCHPQINDGWRRLNESLDLLSSFNCRTVIRMTCVKDYNMIQPEEYAR
IIKKSNPDFVEIKAYMYVGNSRKRLQFDNMPRSKDIQDFATTIAELCDRKIIDQSPESRV
VLLK
>B5YME4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thalassiosira pseudonana|TrEMBL
ILLFVLPTWTDGTLPPDSQVLLQSLEEISTDWRVAPEPLRSSNPQTQLKVGAFGMGSSAY
DAVTVGKPAKDVFSCLVGKLGARPLSLMIGDSEVGDSDVVFEKWMSGIVSSIFTELYTPT
SDTKNGDGSSTDSLSEDEDDDDDDDDAIVDLEDMGNVMKSQSSAMKSSVPKEMVTPKQAK
ALKKEGYKLIGTHSAVKLCRWTKHQLRGRGGCYKHTHYGITSYQCMEATPSLACANKCVF
CWRHHKNPVGREWRWKTDDPAMIVEEAVNMHVDMIKETRGIPGIQMDRWAEAHKVRHCAL
SLVGEPIMYPRINELLHELHEREISTFLVTNGQHPQAINDLVPITQLYVSVDASTPESLE
AIDRPLFRDAWDRLKQSLSCLKRKGQRTVARLTVVKGWNSDEIGGYARLIALGHCSLVEV
KGVTFCGKSDASNLNMTNTPWHHEVVEFTKILRDELNAIREEGGDDPLPEYDLACEHKHS
CSVLLARVDQFAVPDPDDPSNRKWRTWIDYDKFQMLAKKHKVDPTFTFGVEDYIADTPSW
AVFGADEEGFDPTDNRHRRKKKYP
>A0A7K5RGX1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lanius ludovicianus|TrEMBL
LEVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVVQFTTSRTKRKVGENLLQELGA
DKVGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPE
DGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVFGL
GNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWRAKFLTR
LQALCRGEKQPCTGECKKGKCKSSGKQSKESSDHEHGTSEHENSEAEELFETSSEEEAGG
ADSVVDVEDLGNIMDHMKKAKVLLLEGAWNAHGVHHFRYQLVCLVDQFLQAKLNCLMIFA
LFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCW
RHHTNPVGTEWRWKMDQPEVILQEAIENHQNMIKQFKGVSGVKAARLEEALRVKHCALSL
VGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRI
DRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELRAYADLISLGKPDFIEVKG
VTYCGESSASSLTMANVPWHGEVVSFVQELARLLPDYGIACEHEHSNCVLMAHSKFQVDG
EWRTWIDYGRFQELVREHERSGGSRTFSAAEYTARTPPWALFGARERGFDPLDVRFQRKN
KARDISGC
>J9DRC8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Edhazardia aedis (strain USNM 41457)|TrEMBL
MVQIKILYATETGKSLKYASDLSQKLNFPHEVLCFSDYELSQEKALLIIIVSTFFDGKPP
VNGQSLYQQLEDLKNDFRVERNYLKNYKIAIFGLGSLAYDSDFNIVARNMQKFFKDLGAK
IFLKTGLGDEYNDMDTKFLNWTDKLINRIDFLVKEEEAESVFDSYEDIEEAANLDIVSLE
KDSYDQNVDIEDIDKKMLNNSLSKNLEKQGYKLVGSHSAVKLCRWTKSMLKGHGGCYKHT
FYGISSLSCMEITPSLACANKCVFCWRHYTNPVSKTWKWKTDDPLEIFNGLKNGHLEFIN
RFRHTPNVDPLFFENAQKIKHCALSLVGEPIMYPRINELIDILHKNKISTFVVTNAQFPD
ELTTLKPVTQLYLSIDASNEGDLKSIDRPLHNDFWERFIKCIDIIKNRKERTVFRLTVVK
GKNMNDFDGYKNLIKRGMPDFIEVKGVTFCGYKNKDVMNLTNVPFHFEVVEFCKAILIDD
YEIACAHDHSCCVLIAHKKFKSGKIWKTWIDYDLFFAVMNKEDLSSVSYNKPTPSWSEYG
SFEKGFDPNLTPKIRSKNK
>A0A093XD43|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Talaromyces marneffei PM1|TrEMBL
MADSSLVPGLLATWHSFRIPIIVSLAVFFLFVRFTSSKRSKSSLSSSPPPSPRLESAILK
EKPVAPIPEQKSVTALKPAPKPLASGPKRVVGNKDRRVGKNSQKSDGIGGPSYIKPVIFF
ASLTASTQTHAQWLLEQLRTAAQEKSPGNDNEWGLLPPELYDLAEVDFDDHFITAPKAPV
NSPNTRYVYCFLIPTYNIDTIIDTFIAHLDETHNDFRIDTAPLSSLAGYSVFGFGDKEGW
PTEEDGFCSQAKEIDRWMAKLTGKKRAYPLGMGDTKTDAINALKDWTSGLVEILLEVAQT
GGLGEGVAGSGDPFESDEESAAEDEDQPSSKKTQTVVDLEDINFGGSAKKGKGDPIPVDF
TTVSKVQTSQAALKEMVPSTSPTYASLTKQGYTIVGSHSGVKICRWTKSALRGRGSCYKY
SFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWKVDPPEMIFNGVKEGHYKKI
KMLKGIPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLGMLHNEQISSFLVCNAQHP
DQLATLDRVTQLYVSIDASNRESLRRIDRPLHRDFWERFQRCLDILREKRHFQRTVFRLT
LVKGFNIDDEVKEYADLVEKGLPCFIEVKGVTYCGTSSSAGVGLTMKNVPFYEEVVAFVV
ALNDELERRGLGYGIGAEHAHSCCILLASDRFKVDGRWHTRINYDRFFELLEKEKTEGIS
FRPEDYMRETEEWALWGNGGFDPNDQRVRKVRNKKLKNDQTAEQNMTF
>A0A7J2JL19|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon|TrEMBL
MIPTEFKKILEKQHYKIVGRHSAVKLCHWTKRSILDEGFCYKQKFYGIESHRCLQMTPAV
AWCTQKCIFCWRNIEQTLGTKLDEFDEPEDIINGAIEAQRKLLSGYGGIPERINKTKFKE
AQDPNQAAISLSGEPTIYPKIGELIGEFNKRKFTTFLVTNGTLPERLEKLENLPTQLYLS
LDAPNEKIYNRICNPILSENWKKINETIGIFPSLETRKVIRITAIKGLNMLSEEGYARLV
QRAEPDFVEVKAYMFIGGSRKRLSLENMPSFAEVREFSENLSSYLGYSIKDFKEDSRVVL
LSGR
>A0A7R9BXB0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Notodromas monacha|TrEMBL
MLAVSWVFATGWTPFLIALILVVVSFVRSRKEVKIEAPELVQVPKEEPLQVPKKEQLLEA
EKDEVKASKTKKCCSGGGCCSNKEKTHDVMGEVSEVQVFYGTESGTAEKFAEQLVERVGA
LGVEVSLINMKDHDPETLSLLQDKTRVCLFVIPTYEENEPPETAAWFCKWIRDAAQDFRV
SKSLLANFQFAVFGLGDSAYGEDRFCVVAKWLSSSFEELGASRLVSTMFHDLSKANAEQD
FDKWTGNVIKKLFPDRESKDKKCGCNEEEKVVEVVDSSADEQEDEGSALQDLEDLGNIME
LLKKSKEQKMDQESKEMITPALRQALTKQGYKLIGTHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHQTNPVGTEWKWAMDPPDMILSEALEKHAKMIN
EFKGVPGVIVDRFQEGMSPKHCALSLVGEPIMYPEIDKYLRLLHSKGISSFLVTNAQFPD
AIRSVSPVTQLYVSVDASTKQELKRIDRPLFRDFWDRFLNSLKALKDKKQRTVYRLTLVK
SWNAEEIDGYVNLVALGNPDFIEIKGVTYCGTSKNSALTMENVPWHEEVVTFVKGLVEKL
PEYEIACEHEHSNCVLVAHKKFFRDGKWMTWIDYEKFHELMRSFYESDGKLAFSSEDYMA
PTPDWAVFGATEQGFDPAETRTNRKKRETAGVGLYGGHTFEMMRNVTALVGKNSNLRVYL
VALTDPWSAEKALEYEHPHQHSVVLEGKISLLLMPQSLLSLEFHSTKNGNSTKYSLKLIG
FVQLLQAVPRKSILQNLSTMGKTGQNVGRLVS
>A0A2R6LKY9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halobacteriales archaeon QS_9_68_42|TrEMBL
MPKQVSDPDYHSENHTAAQTCGWTANALRGEGRCYKNTFYGIQSHRCIQMTPVVKCNERC
VFCWRDHAGHAYELDGVEWDDPEAVVDASVDLQRKLLSGFGGNDDVPREVFEEAMEPRHV
AISLDGEPTLYPYLPELIKAFDDRGITTFLVSNGTRPEVLKACDPTQLYVSVDAPDRKTF
GEVVKAVEDDAWDRLVETLDVLADKDDTRTVLRTTLLSGYNIHHPEWYAAMFDRADADFV
EMKAFMHVGNSRDRLDRDVMPDHEAVVGFTEAVGEYLPTHPVLRDVEASRVALLAREEDT
WVPKLKGGSEFWEANPYGS
>F2L227|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoproteus uzoniensis (strain 768-20)|TrEMBL
MSCEEEPIGRHHALIGPRLVIRAGTARRLVEAHYGVAGHATVELCKWTKDALDGKGSCYK
VKFYNAPAGGSHRCVEMSPVGMVCSNRCVYCWRPTQEFDTFTPEDWWVMEPDEIVKGVLK
ERERLLSGYWGHEKARERVKEALAPTHWAISLSGEPTLYPKLPELVKLIKSLPHTKSVFI
VTNGQHPEMLERLIKEDALPTQLYLSMNAPNKELYYLINVPVMYREDAWERWLRSLDLLA
SMPTRTVVRITLIRSLNYDERYIPLFAQLVKRGNPHFVEVKSYMHLGYSTHRLKREDMLA
HEEVVEWARKLRDELERIGARFAYMDDDERSRIAVLQNLDRYVDRWIVPPGNN
>A0A8C0JVC6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Canis lupus dingo|TrEMBL
LDPFSDTWDFSSPVISLWINRFYIYLGFAFGISLWICFQIVIRKQGFATSLAEAVTSLDL
PVAVINLKEYDPDDQLVEEVTSKNVCAFVVATYTDGQPTESAVWFCKWLEEASSDFRFGK
TYLKGMRYAVFGLGNSVYASHFNKVGKNVDKWLWMLGAHRVVARGEGDCDVVKSKHGSIE
ADFRVWKTKFLARLQALQKGEKKPCDGNCKRGQCESSRKRERGCESMHEEEPSESTSEEE
SGTEDHQNLNSVVDVEDLGKIMNCVKKEKREKEEQEEKSSLVRNTVKNEDSERRTMITPA
LREALTKQGENPQEVLSQYYPLNPGSNPTSGSRCMEPAPPSACSLEFLPLVLRHHTNPVG
TEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEAMMVKHCALSLVGEPIMYP
EINRFLKLLHECKISSFLVTNAQFPLEIRNLKPVTQLYVSVDASTKDSLKKIDRPLFKDF
WQRFLNSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIEVKGVTYCGESS
ASSLTMANVPWHEEVIHFVRELVDLIPDYEIACEHEHSNCLLIAHKRFKIGREWWTWIDY
NRFQELVQGYEDSGGSATFSAEDYMAKTPHWALFGASERGFDPKDTRYQRKNKSKDISGC
>L8IZI2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos mutus|TrEMBL
LDPALDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISHPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
CLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALRKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHLSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEISFELPRDLKPVTQLYVSVDAS
TKDSLKKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGN
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIA
HKKFKIGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPK
DTRYQRKNKSKDISGC
>A0A523QF56|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon|TrEMBL
MAVSAEELSELELAGYRFVGEHKHSAVKVCHWTRKSLLNRGACYKERFYGRDLGIRSHRC
LQLAPSLPFCDHRCVYCWRNTDVTTPSWVGEVDDPADILDGAISAQRKLLSGFGGNPNAN
KKKFEEAQEPKHCAISLAGEPTFYPNLSELIEECGRRGMTSFLVTNGMHPEVLEHIAEPT
QLYISVVAPDPETYEAVCQPTVPDGWKRLNQSLELMSCFKCRKTIRITLVKGLNLKKPEE
YAKIIEKAGADFIEAKAYMFVGFSRRRLVMENMPLSDEVNGFARELARETGYSIAGESRP
SRVVLLKKA
>A0A1E3PUG5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nadsonia fulvescens var. elongata DSM 6958|TrEMBL
MVHSWHKSRSTVLTVGAVLGSLYYLYTTKPELFNNALQAYQTLTNNNNQSYHKAVKPIPD
EVENNVEEKINPSTAVPMPVDFTTLGKANSTAAVPLKKRAPKKFTSKNSKAQANNCNSNY
AVPSVDSDVIVFYSTLTGTSERYANLLHMKLKEVLTKEPELINIDYIEDLDEYFVAPKRE
NIVYLFVVPSYENESPLDFFLETLKETYNDWRIDSTPLAKLGGYAVFGLGDSENWPEEDK
FCYQAIQTDKWLGKLGARRIFPVGTGCIKTDAEQVLEEWVLHLANTLKDKNIPEMMDIVD
SDDEGTDEEAEAEDNAVVDVEDMGAIIKRTKESNEDVKKQMVAKDSPTYNSLTKQGYTVV
GSHSGVKICRWTKSALRGRGSCYKFAFYGIKSHLCMETTPSLSCSSKCVFCWRHGTNPVG
TTWRWQVDPPKAILDGAMEGHYKKIKQLRGVPGVNSARFAEAMTVKHCALSLVGEPIFYP
HINEFVGMLHEKHISSFLVCNAQHPDELAAMDQVTQLYVSIDAGKKESLKKVDRPLHRDF
WERFQQCLEILREKRNQRTVFRLTLVKDFNTEEIEDYADLVEKGIPCLIEVKGVTYCGTS
KGNPLTMKNVPFYEEVKTFVERLNEALNKRGLAYGIAAEHAHSCCILLAQDRFKIDGVWN
THIDYAKFFELLESGKEFGPIDYVAPTPEWAVYGAEAGGFNPEDTRFRRKTKHNLALAEQ
ERLAQEAKDQAEEKVNSIEEKTTEAVEIVDEEPMEVEFF
>A0A497ELJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Verstraetearchaeota archaeon|TrEMBL
MNKKLLKDLKGYQIVGRHSAVKTCLWLKKSLKDQGVCYKQKFYGISSHRCLQMTPALLCN
QSCIYCWRPLELLKEFDGWDEPEYIVKESIKAQHRLLSGFHGTPGVNKKKLEEAYEPNQV
AISLIGEPTLYPYLDGLIEEYKKKGFTTFLVTNGTNPNILEKVNPTQLYISLTAYDEESH
LILNRPPRSFWDRILRSLKIMRECNSRTVIRLTLIKGYNMSDKAIEKYAKLIDIASPDYI
EAKAYMYLGYSRLRLKYENMPEHADIVEFSERLSKVTSYSIKSESEASRVVLLTR
>A0A7J4F8S3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MPIPQRLIDVYKKQRYHFVGKGAVIKRCHWLYRSLVTRGEETCYKRWYGIRSHRCVQMSP
TLACSARCLFCWRANPLDLNLDWSELHVDVVDEPALIVENSIREQRRILSGYKGNPNVDG
RMLEEAMDPIHAAISLVGEPTLYPHLDELIYEYFSHGFRTVFLVTNGMFPDVLSDLSHEP
SQLYVSVCAPDRDTYRVACRPLLPDGWRRLNETLGLLHSFRCPTVIRITLVRGLNLKDAE
GYAKLVSKANPLYVEPKAAMAVGFFERRLPRGAMPTHTEVRGFAERLAELTGYNVVDESP
PSRVVLLSRLKRPMELV
>A0A7J2TEF6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MLETLVPSTLLQALKKQKYHLIGKHSAVKRCKWLYETLVHDRACYKQKFYGIKSHQCIQM
TPSLFYCTQQCLFCWRAQSGDLKIKWDEMRLPNWDSPEEIFQGSLKIQAKLLSGYKGNAN
TNWKKLMEAFSPRHVAISLTGEPTLYDPIGELIHLFHNKGFTTFLVSNGTMPAKLANLSE
EPTQLYISVCAPNEKVFKQVCRPHFSDAWARLNESLSLLASFRCPTVIRMTLVNGLNMTA
VEEYAELVKKANPTYVEVKAYMHIGFSNLRLSYEHMPKHKDVYNFGTLLAEKTGYKIIDE
AIESRVVLLSKLEKPIRFGFL
>A0A497KJZ9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MKRQPNIKLSSLEFQKILHRQGYRIVGTHCHSAVKICQWTKESLRNNRVCYKELWYPPVE
SHRCMMMTPYLGCNLHCLHCWRLHSGDRPGLRWKEFPLEIEGFDEPAEIIDEAIKQRRLL
LSGWKGNPKVERRKFEEALNPTMMTMSLTGEPTLYPMISEMIEEAEKRNMITFLVTNGTM
PEALEEMDKLPFQLYVSILAPNRKDYIRLARPLVKDAWERLNMTLELLPSLDTRRVLRLT
MIKGWNMNNHESYAKIVNKAQPDFIEVKAYEWVGESQKRLPKNAMPYMSDIEEFAEKLSL
LTGYAIKGRYEPSGAVLLAK
>A0A832GQX8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MQLSYNQHLLITLFKKQKYQLINEHSAVKKCRWLHQSLTQNRYCYKQKFYGVQSHRCIQM
TPSLICNMQCKFCWRIHPNEDLKPPLNFLIQKWSDPEEIVEECIKAQRRILSGYKDQVKK
GKIDGKKYFEALNPKHAAISLDGEPTLYPKLSELIQEFHKKNFTTFLVTNGTKPEVLKNL
SEEPTQLYLSIYAPNKKVFMNLCKPVNISFWDKINESLELLSSFKCPTVIRLTLVKGENM
EDLDGYAKLIEKASPTYIEPKAYMFVGYSRLRLKFENMPSYEEVKAFSRRLAEKTSYNII
DESKESRVILLSKLKKPIKFS
>A0A7J3W746|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Bathyarchaeota archaeon|TrEMBL
MASQENALESFKQTLLKQGYRIVGKHSGVKICEWTKKSLTQGRYCYKQKWYGIESHRCLQ
CSLALFWCLNRCLYCWRSFKVFLGAEMNVEPDDPEWLLDGLIKVQRELLIGYKGNIKVER
SKWEEAQNPTNIAISLIGESVLYPYLSEFIELAGKRGMKSFLVTKGTYPEGLEKLSVEPT
NLYISVCAPDEETFNRLERPIKRNGWKAHMRSLELMKSFNCRKVIRITLVKGYNMHNIEG
YAKLIEKAEPDYIEPKAYMRVGESIRRLPEDAMPSCEEVLEFAEKLANEIGYAVKDLFKP
SRVALLSKNKR
>A0A3M0KCI7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hirundo rustica rustica|TrEMBL
MTVIAVSVGVKTGEKSHGNPSSPEGTADKLGNGCAPAQAQEVHVAGVKIFYGSQTGTAKR
FAKTLAEAVTSLNLPVEVINMGDYDPEDGLAEETSSRNICVFLVATYTEGQPPESAAWFC
KWLEEAANDFRVGKSFLQGLRYAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAE
GDCNVTQSKHGSIEADFEAWKTKFLTRLQVLCKGEKKPCSGKCKKGKCKSSGKQSKESSD
HEHGTSEHENTETEELFETSSEEEAEGTDSVIDVEDLGNIMGHMKKAKRERELEEGAAGA
GRKEEAERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIES
HRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIKQFKGVS
GVKAARLEEALAVKHCALSLVGEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLE
PVTQLYVSVDASTKESLRRIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDE
LKAYADLISLGKPDFIEVKGVTYCGESSASSLTMANVPWHGEVVSFVQELARLLPEYGIA
CEHEHSNCLLMAHSKFQVDGEWRTWIDYSRFQELVGEYERSGGSRTFTAAEYTARTPPWA
LFGARERGFDPLDVRFQRRNKARDISGC
>A0A6P5DYY4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Bos indicus|TrEMBL
MDPAXDTWDFSSPLISLWINRFYIYLGFAFGFSLWICFQIVIRKQNKNSPEKTTPKASQN
LMTNGYISRPKKEVFVSGVKIFYGSQTGTAKGFATILAEALSSLNLPVAMINLKDYDPDD
RLIEEVTSKNVCAFLVATYTDGQPPESAAWFCKWLEEAANDFRFGKTYLKGMRYAVFGLG
NSVYLSHFNTVGKNVDKWLWMLGAHRVMTRGEGDGNVVKSKHGSVEADFTAWKTKFISRL
QALXKGERKHCGGNCKKGKCESNQRGSEVAEPGSHVQEELPHRDAEDEEPFGSTNEEESD
TEDHQSSNPVIDVEDLGKIMDHVKKEKREKEQLEGETSAIRSTVKSEASERRAMITPALR
EALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCV
FCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKEERFEEGMTVKHCA
LSLVGEPIMYPEINKFLKLLHECKISSFLVTNAQFPAEIRDLKPVTQLYVSVDASTKDSL
KKIDRPLFRDFWQRFLDSLKALAAKQQRTVYRLTLVKAWNVDELQAYAELVSLGNPDFIE
VKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEVACEHEHSNCLLIAHKKFK
IGREWWTWIDYSRFQELIQEYEDSGGSKTFSAKDYMAKTPHWALFGANERGFDPKDTRYQ
RKNKSKDISGC
>A0A147JZN5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hadesarchaea archaeon DG-33|TrEMBL
MAVSADELSELELAGYRFVGEHKHSAVKVCHWTRKSLLNRGVCYKERFYGRDLGIRSHRC
LQLAPSLPFCDHRCVYCWRNTDVTTPSWVGEVDEPADILDGAISAQRKLLSGFGGNPNAD
KKKFKEAQEPKHCAISLAGEPTFYPNLSELIEECGRRGMTSFLVTNGMHPEVLEHIAEPT
QLYISVVAPDPETYEVVCQPTVPDGWKRLNKSLELMSCFKCRKAIRLTLVKGLNLKKPEE
YAKIIEKAGADFIEAKAYMFVGFSRRRLVMENMPLSDEVNGFARELARETGYSIAGESRP
SRVVLLKKA
>A0A7C6GZU7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MTIDVKRTLEKQQYRIHGDHAAVKLCHWMKQSLLKGRTCYKQDFYGISSHRCLQMTPVVN
QCTHNCLFCWRVQGFEAAEVPWKDPEEILDHCIEEQRKLVSGLGGDPRCTRDMWQESREP
RHVAISLSGEPTMYPHLAGFIDVCHRRGMSTFLVTNGTLPEVLERLDPLPTQLYVTVAAP
NEEVYKRLCVPRIPDGWERLNRTLELLPSLNTRTVIRHTLVKDWNIGWEHEYAKLDEKAE
PMFIEPKGYVFVGDSRRRMTIDNMPSPAMIGEFSDRLGNELGMEVLKERRDSRVAVLGRP
GAKLSLF
>A0A2E9WFB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPALKATLQKQRYHIVGEHGGVKTCHWTKESLLRDRACYKGTFYGVKSHTCMQMSPVVD
QCNLACTYCWREPHMDTLELTDQDPQELLYESVRAQRRLLTGFGGNDKVNPEKFAEAQDP
KHVAISLNGEPTLYKRLAEYMDLCHQHGMTTMLVTNGTLPKVLEKLDTLPTQLYVSVDAP
NKQVFDDVCRPKWNSGAWKQFEKTIDLLPSLDTRIVCRHTLMKGVNMSENHIREFAAIDR
RADPDWIEAKGYVYVGHSREHLSIDNMPSHEDILTFSESLAPQVDMRILSESRPSRVALI
GNEMIPIPIPEATMHFPEDLGTAPPVKKLKLATIS
>A0A7K5KH76|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Mionectes macconnelli|TrEMBL
LDVSMDTWSCFHACLASIWLHRFYIYSAVALGISLWIVIQFTTTKTKKKVEKSSGNPTSS
RGTEDKLVNGCATPQAKEVYVAGVKIFYGSQTGTAMRFAKALAEAVTSLNLPVEVINMGD
YDPDDCLAEETTSRNICVFLVATYTDGQPTESAAWFCKWLEEAANDFRVGKTYLKGLRYA
VFGLGNSEYVDHYNTVGRRVDRWLWMLSASRVMTRAEGDCSVARSRYGSIEGDFQAWKAK
FLTRLQALCRGEKKPCSGKCKKGKCKSPGKQSKENSDHEHGASEHEITEAEELFETSSEE
EADAEEAGGTNAVIDVEDLGNIMGHMKKAKGAMRKSSTEAVMLNPFGYPLVCFISQLLQV
TISSSLFCALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGTEWRWKMDQPELILQEAIENHQNMIKQFRGVSGVKAARFEEAL
KVKHCALSLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIRSLEPVTQLYVSVDA
STRESLRRIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWNVDELKAYAELISLG
KPDFIEVKGVTYCGESSASSLTMANVPWHEEVVGFVQDLAELLPDYEIACEHEHSNCLLL
AHTKFKVDGEWFTWIDYERFQELVREREQSGGSRTFTAADYMARTPPWALFGARERGFDP
LDVRFQRRNKARDISGC
>A0A327GYG9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MEPKIAARLAKQRYHLVGDHGGVKVCHWTKQSLIADRSCYKGTFYGIESHGCMQMAPNVD
TCNLGCTYCWREPHSDTLNKIDDDPYELYLQSVKAHRRLLTGYGGNPKADREKWLEAQNP
KHVAISLNGEPTLYSRLGEFLEVCHQHGTSTFLVTNGSLPKVIENLDPLPTQLYVSVDAP
NKEIFDRLCKPKFDQAAFNKLEETLGILPSLDTRTVCRHTLIKGESLGYHDEYARLDNLA
DPDFIEAKGYVFVGNSRNNLSIENMPSHEEVMEFSRTLAPLVGREVLSDRKESRVSLIGK
EMIPVKLPEKTRDLPQDLGIAKPQNFSLPVTLN
>A0A2E6KXA2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDLALKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGKFYGIASHNCMQTSPVVD
QCNLACTYCWREPHMDTLELTDQDPLELLYESVRAQRRLLSGFGGNPKVAREKWLDAQNP
KHVAISLNGEPTLYRRLGEYIDLCHKHGMTTMLVTNGTFPKVLERLDPLPTQLYVSVDAP
NKEIFNKVCKPKWNSRAWEQFEKTIDLLPSLDTRIVARHTLMKGINMSDRNIREFAALDN
RADPDFIENKGYVFVGNSRENLSAENMPSHDDIMEFSAKIAPLTGRKILSDSKPSRVALV
GQQITPIPIPKPTMFFPEDLGIAPPVKHLPIIQ
>A0A2D7BXI5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGDHGGVKICHWTKESLLRDRQCYKGRFYGVASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELSDQDPLEMLYDSVKAQRRLLSGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYNRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNSAAWDKFEETIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILEFSRTLAPLTGRKLLDDSPPSRVALV
GKEIIPIPIPEATMQFPEDLGIAKSIKHLKIVQ
>A0A534K9D8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Euryarchaeota archaeon|TrEMBL
MDPAKREVLERQGYRVVGEHSGVKVCHWTKNSLTKGVGCYKETFYGIKSHRCLQMTPTVD
SCNLGCLFCWRTQEWGSDSLVHADDPGFVVEESIEAQRHLLSGFKGNPKVSKEKFSEAWN
PNQVAISLTGEPTLYRRLGEMIDEFHRRKMTTFLVTNGTTPAVLRRMAAEGRLPTQLYVT
VAAPNADVYRRLMAPKSEHEWEKLRETLALLPSLNTRTVVRHTLVEGWNLGWEDEYAALD
AIARPMFIECKGYSFVGESRLRLRVENMPEHAAIREFAERLGERLGYRPAAEREDSRVVL
LTQDGELHPIPS
>A0A093XCI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pseudogymnoascus sp. VKM F-3557|TrEMBL
MANNDYLGADIASDAMENYIMVLWHTYRIPILLTVFVVLLITRTVLYLKVGREKIIYTPP
ATPSEKAPVAAVSQREQLVEKAPISAEVKKAGPKRVVGKVTRKKSPLRDQPANKDVKFQV
LVFFSTLAGSTERTAQALTTKLGETLKAGAEKTQYEFLEPVSHDLAELEDYDEYFLGLPK
SEDGGPDIKYFYILLLPTYNIDTMTDTFIEHLQETHNDFRIDTAPMSALLGYAVFGFGDR
EGWPTEAEGFCSQATEVDRWMAKLTARKRAFPLGMGDTKVDAQERLDEWRKGVEDVLQNL
GQTGNLGEGVVGSGDADESDVEDASDGETEVQSDGAVKLKRKSKKKAESSMDDVEDIGRI
LQKGQAESEDQDDDDSGAIDFTTYGKKTPKPIAALKEMVPKGSPTYNALTKQGYTIVGSH
SGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTW
RWVVDQPEDIFNGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPISYPYLN
EFTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWER
FQRCLEILREKRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSS
SGAAGLTMQNVPFYEEVCAFVLALTAALEKRGLKYGIAAEHAHSCCILIASDRFKKEGKW
HTRIDYAKFFEHLESGKPFTPEDYMGPETPEWATWGNGGFDPRDERVYRKGKNKVPLRVE
GEKGEKEVEAKEEKKMLVEI
>A0A369S0J1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trichoplax sp. H2|TrEMBL
MVVLRTSKFDRSYLPLITIILVIYVSGFSVLANDDESDTETSGSVLTKGTTSCSWKLSTW
LAAILLGSVALIFYKKGLINEQISNTNQGKETSIRVYYGSQTGTAKRFAERLYSDLKALF
SDEQDAHRVTMNIYSLNQQEPEDVIAIKPKSRQICIFLLSTYTGGEPAESARWFYTWLQD
TVSDFRVQKTLLSKLNYAVFGLGNSVYQEHFNSVAKDTDSWLHKLHGNRILPLGIGDNNV
VQSENGGLEEDFVAWKGRILRVLNLEITPSHKPVDNEVNVAPSKVKILYESTSESSDNSE
DEETIAMKKNSTIPIKNDVVDVEDLGMMLNNLGKAKADRELEVSTLQRVQAGPKTSISSL
KKAELRDMVTPSLKEALSKQGYKIIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRC
METTPSLACANKCVFCWRHHTNPVGTEWRWKMDDPEKIFNEALKNHYGLIKQFKGKLGHL
RIRTIILFCKHNGKNLTDFLGVPGVQTERFKEAMEVKHCALSLVGEPIMYPEINKFIELL
HGKEISSFLVTNAQFPNAIRDLTPVTQLYVSVDASTKESLKKIDRPLFKDFWPRFLKSLS
ALSEKGQRTVYRLTLVKAWNAEEIEAYANLVGYGNPDFIEVKGVTYCGESKASKLTMENI
PWHQEVLSFTDKLVDNLPEYEIACEHEHSNCVLVAHKKIAEFASNGGKNFDASDYMALTP
DWAVIGHPAHGFDPVETRWHRKKNNKDIGGC
>A0A8C4EYD3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dicentrarchus labrax|TrEMBL
MALKKKSFPKDVGTLVYKAVKKDDRDAVVHVSGVKIFYGSQTGTAKAFAKELSEEVKASG
IPAEVIDMKDYDPDDQLADECTNKAVCVFLVATYTDGQPTENAEWFCKWLEEASTDFRYG
KTYLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSGMRIMTRGEGDCNVVKSRNGSI
QADFLAWKVKFLNRLQALAKGEKKTCSGNCKTGGSCKNKRKEGHEQEEEEEEEAQQNNSS
EMNGLKKTEDEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHT
FYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAETILQDALEKHQNMIR
QFRGVPGVKPDRYEEGLAVKHCALSLVGEPIMYPEINTFIRLLHSHHISSFLVTNAQFPQ
EIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLRALGEKRQRTVYRLTLVK
SWNVEEMQAYSELIALGQPDFVEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLTDML
PQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVQAHEESGGQQSFSALDYIA
KTPSWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A5Q0SL84|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Sulfolobus sp. E5-1-F|TrEMBL
MYNMQSNLRIDTISEIFKELQKEKYHLIGTHSAYKKCHWTHSALVANRSCYKGKFYGIES
HRCVQMTPTAAWCWFRCVHCWRLEPEDVGLEWDDTKMPAYDDPEYIVERSIEEHKKAVSG
YLGRNDVNIQKVKDAMRPAHVAISLTGEPTLYEKLGDLIKEYHKRGMTTFLVTSGVRPDI
LASLEEEPTQLFVSLQAPNEMKHKMINRPVVANSWQLVMKTLEILPSFSSPTVIRFTMIK
GYNMSEQDAREFAKLMEIAMPTYIEIKAYMHVGPSTYRLSRDAMPKHKEIREFAKILAQY
TGYNILSEHVPSRIVLLSKLDKPIKIGNAWNEKWDWSTIDMEDDMSGEYKEAEQGCTEGS
T
>A0A1V5A155|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregulaceae archaeon PtaU1.Bin222|TrEMBL
MCYKHQFYGIDSHRCVQMTPTLRCNQRCLFCWRSFEHEYPGERDLSPEEIVGSVRKYQKK
ALSGYKPSPYVTQERFSEALDPKHVAISLSGEPTLYPYLPELIDLFSSEGFTSFLVSNGT
RPGVLAKCRPFQTYISLTAPDRETYMKVCRPLEDTWDAIQESLSLMGSRRSAVRITLVKG
YNDHEPGSYARMIQESGTSFAEVKGYMFLGYSRNRLERGNMPSFAHVKGFAEKVAAECEY
RVRDENPLSRVVLLERVE
>A0A7J4QAL2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Nanoarchaeota archaeon|TrEMBL
MLDPKIKADFERQGYRIVGNHSAVKVCLWCKKSITGKDKCYKNTFYGIQSHRCIQSSVSL
LNCTHKCEFCWRCLDFTVPKSVENPDNPSFILDGLIRGHKESLQGFKGNKDVTKKLFNEA
MNPRHVALSLAGEATLYPYLPALLEEIQKRKMTSFLVTNGTMPEMLEKLLKHKPTQLYIT
LPAPDEETYKRTCKPLLKDSWQLLMKSLALLHKFGRGTVRLTLVKGLNMINPEGYAELIK
KAKPLFVELKAAMPVGYAQYRMAYEQMPSHAEILDFAKKICTETGLKTVDEKPNSRVVLL
MKKDKKSRKIKL
>A0A6L0WHS7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Leishmania infantum|TrEMBL
MITFLLQLFASLGLPLVAFLLYSHLADSVHTRGNVAGGDAGAVDDAIIFSQRVRAELEQL
DVASAPPSAAPAQSPPPARMTPSPAVAVPPAPVAAEILIAYATQSKNSLALAHKLFSLIT
AQLQTASPAAAEDVICPLVRVMEMREEEVGIKNVCRVDTLLEQNQYALIIFIASTYTDGV
APPRSQAFEAMLKDAFEDHRIPRNTLGRKRFAVFGLGDIAYGEERFNAFAKNLHEWCRGL
GAPPFVVPPVYATEAKTQSLFRIFSTALLKWVSRATFHTDGTVTVKKKSEMVATSPAAAS
ATEARSCKGGSATVATANTSIISAAAGGTCGKEGGPCACQQSSQQLCGSRAGGDGDDGCA
CRKADTIADGVAVSKSDDDDDDSNAENDGMDDVEDLVWDGTDDADFDLSKDPSELPELLY
PKLRQNLEKQGYRLVGSHSGVKLCRWTKSMLRGRGGCYKHTFYNINSSQCMEMTPSLACA
NKCVFCWRHHTNPISRHFRWKQDPPELLIAQGMAGHYQMIKQMRGVPGVTPERLAMAMQI
RHCALSLVGEPIMYPQINGFCELLHQHRISSFMVTNAQFPEQLRNLKPVVQLYLSIDAPT
PEELKRIDRPLFEDYWDRCLSCVKELARKQQRTVFRLTLVNQYNTENVKAYADLVEMGQP
DFIEVKGVTYCGTSSNSTLNMKDNVPRHDEVVGFCKALCAEMASRHPHYRTPQMDKEEEG
GGDVIVIPAEERNRPYHVACEHEHSCCVLIALDKFFFDGHWHTWIDYERFYDLVESGRTD
FTSLDYAAVTPTWATYNSKEKGFDPEQTRVVRKNARPTTVTASC
>F8AG72|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pyrococcus yayanosii (strain CH1 / JCM 16557)|TrEMBL
MAIVVRSNPNMPEEIAGLFRKQHYIIVGHHSGVKLCHWLKESLTKGRFCYKQKFYGIHSH
RCLQMTPVTAWCTHNCIFCWRPMEGFLGTELPEPWDDPAFIVEESIKAQRKLLVGYKGNP
KVTKETFEEAWHPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMI
KEDKLPTQLYVSVTAPDIETYNRVNIPMIPDGWDRILRTLELMRDLPTRTVIRLTLVKGE
NMHNPEGYAKLIMKAKPMFVEAKAYMFVGFSRNRLTINNMPSHDDIKAFAEALVRHLPGY
HIEDEYAPSRVVLIMRDDVEERFIKH
>A0A317UWE2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus heteromorphus CBS 117.55|TrEMBL
MAETATQGLLAFWHLYRLPLLIALATVFVIVRAYRKLQPKSKIATASSIPSSPRSHSPEK
SEKVASHDEKITEKETNTEVVEKEVPAKPAGPKRVSGKKPLKVASRRGGSDQESPVSFIQ
PIVFFASLTGNTERYAQVLLEDLRAAAHDQADPENRERGLLPPQIHDLSYVDFDDFFLNT
PKAPSTSPGTRYVYCILVPTYNIDTILNTFLAHLDETHNDFRIDTAPLAGLAGYSVFGFG
DKEGWPTEEEGFCSQAKEMDRWMAKLTGRKRAYPLGFGDVKNDAESSLKEWTLGLQDILG
EIVSNGGLGEGVVGSGDPLESDEEEDLDDEGSSTKASGRKRNKAQGVVDLEDIKFSSENG
SGAPIPVDFTTGGKPSAPETDKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWTKSALR
GRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPELIFNGV
KEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSEHISSF
LVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHI
QRTVFRLTLVKGFNVDDEVLGYADLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQNVPFW
EEVQQFVTSLDKELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDKFFRLLE
KEKADGISFTPEDYMRETEDWALWGNGGFDPNDERVYKKGKKKTIQAAEEVQGSS
>A0A146FBK3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus kawachii|TrEMBL
MLDQIFQNRANLVAVYREQDKLKEAENIWGEVFEQVFERIKGMVWIYRRQGKRKEAEELR
DKMLQLKKEIYGLLAFWHSYRLPLLLALATLVVLVRAYRKLQPKSKIATASSIPSSPRSH
SPEKREKTISQSTEKDVKADSKPSVVEKDASQKQAGPKRVTGKKPLKVAGRRRGSDQEPP
VSFIQPIIFFASLTANTERYAQVLLEDLRAAARDRADPENRERGLRPPQIHDLSYVDFDD
YFISAPKPPSTSPGTRYVYCMLIPTYNIDTILNTFLGHLDETHHDFRIDTAPLSGLAGYS
VFGFGDREGWPTEEEGFCSQAKELDRWMAKLTGRKRAYPLGFGDVKSDADSALKEWSRGL
QDILGDIVENGGLGEGVPGSGDPLESDEEDLDDEGSDSDKANGRKRNKNQSVVDLEDIKF
NSDAASGSPIPVDFTTGGKTPAPATEKEMVPKTSPTYASLTKQGYTIVGSHSGVKICRWT
KSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDDPEL
IFNGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINRFLDMLHSE
HISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILR
EKRHYQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFIEIKGVTYCGTSTSAGAGLTMQ
NVPFYEEIQQFVTSLNAELERRGLKYGIAAEHAHSCCALIASERFHVNGKWHSRIDYDRF
FQLLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDERVYRKGKKKAIQAAVETQG
>A0A667YTK7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Myripristis murdjan|TrEMBL
IFFFIFIIVMWTMCLSFYLLSGRPTSPLYIIEFLCSVVSLILLVCFDLLAVQCSNKSVCV
FLVATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLRGLRYAVFGLGNSVYVGHYNTVGK
DVDKWLWMLSGMRILTRGEGDCNVTKSRNGSVQADFQAWKVKFLSRLQDLAKGEKKSSTG
SCKSGSGSCKSRTKRSQGQSEEEKAALHDNFEVMMEERSIKFLILLVWLLVVNVLTPEGS
RLMVKLSKVNGVKKIENEGERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGR
GGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWHWKMDPAEKILQDALE
KHQNMIRQFRGVPGVKQERYEEGLAVKHCALSLVGEPIMYPEINAFLRLLHTHRISSFLV
TNAQFPQEIRNLVPVTQLYVSVDASTKDSLKKIDRPLFRDFWPRFLDSLKALGEKRQRTV
YRLTLVKAWNVEELQAYSDLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFV
QQLADMLPQYEIACEHEHSNCLLIAHTKFKVDGEWWTWIDYERFQELVEAHERSGGQRSF
SALDYTARTPGWALFGAHEQGFDPADTRFQRRNKTKDISGC
>A0A523AAD0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobi archaeon|TrEMBL
MKQLADLKGYQLIGNHSAVKTCLWLKKSLKDLGFCYKQKFYGIQSHRCLQMTPALLCNQS
CIHCWRPLELLKEFKGWDEPEKIVEESIKAQKRLLSGFYGTEGVNLKKLKEAENPNQVAI
SLIGEPTLYPYLPELIECYKRRGFTTFLVTNGTMPEVIARVEPTQLYISLTAFDEKSHIE
LNRPVRSFWERILRSLEVMSESNSRRVVRLTLIKGLNMHEKAVERFDQLIKIAEPDYVEA
KAYMFLGYSRLRLKYENMPSHEEVLEFSRKLGYEIVDESEQSRVCLLRP
>A0A1I3KIB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natronobacterium gregoryi|TrEMBL
MSEPADSGVGPGIDADDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIWYGI
ESHRCIQMTPVVKCNERCVFCWRDHQGHAYELGDVEWDDPEAVVDASIDLQKKLLSGFGG
NDEVPREVFEEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITTFLVSNGTNPDVLRE
CEPTQLYVSVDAPERHTFDEVVKAVADDAWERLLETMAVLAEKDETRTVLRTTLVDGENM
HHPDWYAGFYRLADPDFVELKAYMHVGHSQGRLDRSSMPDHETVAAFAREVGEYMPEFTE
CKEVPPSRVALLSKTDDTWVPKLKKESEFWAREPDR
>A0A7K9BMZ5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Psilopogon haemacephalus|TrEMBL
LGASVDTWDFFSASLVSLWLQRFYIYVAVAFGVSIWLVVRFAATKREKASIGHQTAAEGT
EDKLVNGYATPRAKEVYVAGVKIFYGSQTGTAKRFARGLAEAVAPFNLPVEVISMGDCDP
DDCLSEETSSRNICVFLVATYTDGQPPEAAAWFCKWLEEAANDFRYGKSYLKGLRYAVFG
LGNSVYAEHYNTVGRSVDRWLWMLSASRVMTRAEGDCNVAQSKHGSIEADFEAWKTKFLS
RLQALCTGEKKPCSGECKKGKCKSQGKQSKESSDHEPGVSESETAEAEELFESSSEEEAD
AEEAGGTNSVVDVEDLGSIMSHMKTKVQCGWTWSDFLFFFFPPLLLLFPGYKLIGSHSGV
KLCRWTKSMLRGRGGCYKHSFYGIQSHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWK
MDQPEMILQEAIENHQNMIKQFKGVSGVKAARLEEAMRVKHCALSLVGEPIMYPHINQFV
RLLHQRGISSFLVTNAQFPDEIRNLEPVTQLYVSVDASTKESLKRIDRPLFKDFWQRFLD
SLKALSEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGVTYCGESSASNLTM
ANVPWHEEVVHFVQELADLIPGYEIACEHEHSNCLLIAHEKFKISGEWWTWIDYDRFQQL
VQEHESSGGSQTFTAADYAARTPHWALFGSRERGFDPLEVRYQRRNKVRDISGC
>A0A2P6NGQ6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Planoprotostelium fungivorum|TrEMBL
MDLTLTVGVIAAFLVIFLFRYLSNRQAAPAPVRQPAVVKEFHIEEVTLEEPKKDESCACK
EGNTTDEKTSCCRSNDNDDCKKDQIMNARVLYGSQTGTAKEWAHHLAANLRSEGYKATVS
DLATFEPDELSQLSLVFFVISTYTDGKAPDTCIGFYEWLEDMSHDFRVPKDFYSKLKYSI
FGIGDSIYGDNYCTTAKEMDKMLQRMSAQRVAPIGFGDSGTSVEIKDGYKPWFKGVSAGL
NGSQKQDKKQTKTKPKKKVELGRISEEPDELSDDEEVKENITDVEDMGKFVKPVPQKKKK
VEIQEEEEEEDEEEDDDDEELELVEGQAPKEMLTESLRKSLTKQGYKLLGSHSGVKMCRW
TKAMMRGRGGCYKHTFYGITSSQCMEMTPSLACANKCVFCWRHHKNPVGKEWRWVVDEPD
MLVDAAMKNHYGMIKQFRGVPGVTKESFEEASTIRHCALSLVGEPIIYPYINRFVQLLHE
KNISSFMVTNAQFPDKIETLDPVTQLYVSIDAGTKESLKKVDRPIFGDFWERFLGSIEAL
KRKGQRTVFRLTLINGWNTEEISNYAQLVELGAPTLIEIKGVTYCGTSKASTLTMKNVPY
HQEVLHFSQALCDSTPFMKENYEIACEHEHSCCVLLANKRFKVDGVWHTWIDYPKFHELA
ASGKDFTAEDYMAPTPYWAVVGSEEKGFDPEQVRHKRTKPYAGQGC
>A0A7U3GQF1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeum sp|TrEMBL
MANMPEQLQKRMEKQGYHFVGQHSAVKICEYTANGLRGETLCYKYTFYGIRSWQCIQGTP
AIGCDIGCRFCWRLIPEEEGFKWNELNALSEWDDPEGIVEGMIKEQRRIVSGYKSIADNE
LKMRRWNEANEPKHVAISLTGEPTFYPKLAGLLSAFHKKGISTFLVSNGTLPEAIAKLDP
LPTQLYISLQAPDEETYIYVTRPKIKDTWNRFMKSLDMLHTLKTRTVLRMTLIKGLNMKN
EEGYAGLIKRAMPNYVEVKGFSYVGGARNEERGLSLSSMPNHSEIRDFADRLAELTGYKR
VSEHAPSRVVLLARDEESARNRIIDFSKIG
>A0A6J0HYF8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Lepidothrix coronata|TrEMBL
MDTWSYFRTCLASIWLHRFYIYSAVALGISLWIVIQFTTTKTKKKGEKSSGNPPSSKGTE
DKLVNGCATPQAEEVYVAGVKIFYGSQTGTAKRFAKALAEAVTSLNLPVEVINMGDYDPD
DCLAEEATSRNICVFLVATYTDGQPTESAAWFCRWLEEAANDFRVGKTHLKGLRYAVFGL
GNSVYVDHYNTVGRRMDRWLWMLGASRVMTRAEGDCNVAQSRHGSIEGDFEAWKAKFLTR
LQALCRGEKKPCSGKCKKGKCRSPGKQSKESSDHERGASEHENTEAEELFETSSEEEADA
EEAGGTNSIIDVEDLGNIMGHMKKAKREHELQEGDVGRRENPGRKEEEEEEKREMITPAL
RDALTKQGYKLIGSHSGVKLCRWTKVCSLSFSLLGNKTKLETYSVDAPGPRGLLQTHLLW
DESHRCMEATPSLACANKCVFCWRHHTNPVGTEWRWKMDQPELILQEAMENHQNMIKQFR
GVSGVKAARFEEALTVKHCALSLVGEPIMYPQINRFVRLLHQHSISSFLVTNAQFPEEIR
SLEPVTQLYVSVDASTRESLRRIDRPLFKDFWQRFLDSLKALAEKEQRTVYRLTLVKAWN
VDELKAYAELISLGKPDFIEVKGVTYCGESSASSLTMANVPWHEEVVGFVQDLAELLPDY
EIACEHEHSNCLLLAHTKAVLPWSWRHTV
>A0A8H3P576|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus udagawae|TrEMBL
MAEHPITEGLLAFWHSYRLLFLVALSTVFLGLRFYRILQSRTKTTASSSIPPSPRSQSPE
KTDKGTSLKSSNPATTQKAERQLPLANGPAKGTSGPKRVTGKKPSKVAGRQGQTEDAEPL
SFIQPIIFFASLTGTTERYAKILFEELRAAAQKRADLQDRERGLLPPQIHDLSYIDLDDY
FTSAPKPPPNSPGTRYVYCLLIPTYNIDSILNTVLDHLNETHNDFRIDTGSLSSLAGYSV
FGLGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGLGDVKSDAESSLKEWSQGLQ
DILFDILENGGLGEGVPGSGDPVESDEEVDDEDVDKSNAQNVMDLEDIKFGGDQNAAGSP
IPVDFTTTGKSSSGQPTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRWTKSALRGRG
SCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPELIFEGVKEG
HYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHGERISSFLVC
NAQHPDQLEALHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDILREKRHVQRT
VFRLTLVKGFNVDDEVIGYANLVEKALPCFVEIKGVTFCGTSTSAGAGLTMQNVPFYEEV
AQFVTALDAELQRRGLKYGIAAEHAHSCCVLIASERFHVNGKWHTRIDYDRFFELLEKEK
ADGTSFTPEDYMRETEDWALWGNGGFDPNDKRVYTKGKKKNMQITVEP
>W9Q7S0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Fusarium oxysporum f. sp. pisi HDV247|TrEMBL
MDWANYSSPSRLDSFVDDLVDVWHLHRTPILLTLCVILVAIRTYFHINGQKTEIVAFKKV
YEEPAKPKVVVEEKTPTIEPVEEKKNGKSQGPRRIKGGIARKPSKNKEEEKDLTRPVAPL
VFFSSITTKTAKIAEAYIEDFCGKLDELSKLSGRQFLKPELRDLTEIDFDDYFLAPYKGH
GDADLFYLFLIPSYNIDTINDTFLEHLQETHHDFRIDTAPLSGILGYSVFGFGDSENWPT
EADGFCFQAMEVDKWMAKLTARKRAYPVGMGDMKSDHEERLQEWSKGVQEVIEHVARTGS
LGEGVPGSGAAEESDVEDIAEDEDDGEVVFDDEEPKKKSKSARDLDDVEDLGRLIKKDDG
STTQKAPLAVDFTTYGSSTKKAVPQGPKEMVAKESPTYKALTKQGYAIVGSHSGVKTCRW
TKSALRGRGSCYKYSFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPE
LIFEGVKKNHYQKIKMLRGVPGVRAERFAEAMQIKHCALSLVGEPIFYPYINEFLGMLHA
ERISSFLVCNAQHPDQLAALKVVTQLYVSIDAADKESLRKIDRPLHRDFWERFNRCLDIL
REKRFHHRTVFRLTLVKGFNVEEEAEGYARLVEQGLPCFVEVKGVTYCGTSTSSNAGLSM
SNVPFYWEVCDFVKALEKRLKEKGLKYGIAAEHAHSCCILLASERFYVDGKWHTLIDYKK
FFELLESRGPPDEGGWTPEDYMDATPTPEWANWGNGGFNPEDERVDRKGRKIEA
>A0A4Q9KYW5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Hamiltosporidium tvaerminnensis|TrEMBL
MSVNIFYATETNKSLKYAIKLSNALISKNIDVGVHSFDDYFYSEIALFITSTFYDGQVPK
NGRVFFKKLKIAAKNNDLEFKPPKFFAIFGLGSTAYLSLFNLVAKQIYGYLITLNSISML
SPVYSDEYGDMEAVFDNWVSNVCDSLTNNNYQTNQNPKSSEIIDTNNKPDVSDIEDLSLM
LTPSLSKNLKKQGYSLVGTHSAVKLCRWTKSMLKGRGGCYKNTFYGIISSSCMEATPNLA
CANKCVFCWRHYTNPVGTKWRWNADEPDKILKGMLEEQNKLINSVINGVKTEINKFKGVK
HCALSLVGEPVMYVHINKLIELFHKEKISTFLVTNGQFPDQMRALKDVTQLYLSIDAGDP
VSLREIGRPLFTDYWERLLECIDILKEKRGRTVFRLTLVKGINDETTDSNKEEQERNENI
LGGYISLIKRGTPDFVEIKGVTFCGWTQDSGLSMKNVPYHNDVINFAIQLINGLEGYEIA
CEHEHSCCILIANTKYKKNQKWYTWINFDKFNEDLQGIEYSCETPDWALFGSREKGFNPN
ETRYQRKKNQIK
>A0A4D6H933|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halapricum salinum|TrEMBL
MSESDGPKQVDDPDYHSVNHTAAQTCGWTDNALQGEGKCYKYVFYGIESHRCMQMTPVVK
CNERCVFCWRDHAGHAYELGDVEWDDPEAVVDASIDLQRKLLSGYGGNDNVPDDVFEQAM
EPRHVAISLDGEPTLYPYLPELIEEFHARDITTFLVSNGTNPEVLERCDPTQLYVSVDAP
DRGTFENTVKPVEEDLWERLIETLDVLAAKDDTRTVIRTTLVGGENVHHPEWYAAMCDRA
NADFVELKAYMHIGHSRGRLDRNSMLDHDDVVEFAEEMQRFLPAHDEIKEVPESRVAMLS
TENDTWVPKLKKQSDFWADDPLVEYGD
>A0A3Q2C6F3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinodon variegatus|TrEMBL
MFARFAVMLALFVVISLFKGSFSTLDSEVAQDVHGENYLLWMWSNRLYIYSAAALLLGLF
FFLGRRKIINAKDSGSKIQQAAKNNNRPEKDADVYVSGVKVFYGSQTGTAKGFATELSKD
VQTLGFPAEVIDMKDYDPDDRLADECSSQSVCVFLVATYTDGQPTENSEWFCKWLEEAST
DFRYGNTFLKGLRYAVFGLGNSVYVGHYNTVGKNVDKWLWMLSAKRIMSRGEGDCNVVKS
RNGSVQADFQAWKAKFLSRLKALAKGEKRSCKDEGCCKNRKKHGEEKEEKAVMQENSSEM
DLIESSSEEEESVLPDEKASRSVVDVEDLGNIMNNVKKAKVRKEDQVNGQMVKLSKLNGV
SKTEGEEERREMITPALREALTKQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIE
SHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDALEKHQLMIRQFRGV
PGVKPERYEEGLAVKHCALSLVGEPIMYPEINTFLRLLHSHGISSFLVTNAQFPEEIRNL
VPVTQLYVSVDASTKDSLKKIDRPLFKDFWPRFLDSLKALGEKRQRTVYRLTLVKAWNVE
EMQAYSELIALGQPDFIEVKGVTYCGESSASSLTMANVPWHQEVVAFVQQLADMLPQYEI
ACEHEHSNCLLIAHTKVRAQQLNPMKKANTQPSAVTYGQNE
>A0A818G6M1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Adineta steineri|TrEMBL
MTVDLYLLTAGSALTGLIFYYFGGAEWTFWHLFTVPLFTLVFVIFSSLSVIKRFKSSPKS
ASSKKIIPLENNGVTIVFGSVKGNSRTFAQSTYDKLSKDLNRQVIIQDFNDVTDPEEFLQ
TQAKNQRTLLVFIPTYEDATPPPSAKWFLLHLQEAATDFRVSKGELEKLTYAIFGCGNSL
YFENFNKVGKEVDRCLSELGAKRLLPTELADENTAKSIYGGQEGHYSKWSSKLKSALETP
KTEKCDCSNDTSTTTCCKTVTNGDHSIKNDDNNNDDDEEEPRIESDDDDEAGGCKDGNDD
IIDLEDMGEYMENSSPTKTPKGPPKEMVTPLIRKSLEKQGYKLIGSHSGVKLCRWTKSML
RGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHSNPVGTSWQWKTDDAKTVTQG
AIDNHYKMINTFKGVPGVLPARLAEGMKIRHCALSLVGEPIMYPHINELIEILHSKQISS
FLVTNAQFPDEIKTLQPVTQLYVSVDAATKESLKKIDRPLFRDFWERFLACLRALKDKGQ
RTVYRLTLVKGFNTEEIEQYAKLVELGDPDFIEVKGVTYCGDSGASSLTMANVPWHEEVV
TFVQALCERLPQYEVACEHEHSNCLLLANTKFRIDGKWHTWIDYDRFQELVARHKATSGA
ETFTSLEYMAATPDWAVVGANERGFDPSDTRWHRKSTAKKDLSGC
>A0A7J2ZE11|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MRKQHYHLVGSHSAVKACKWLRESIIGRRTCYKNTFYGINSWQCVQCSPMVGCNLACRFC
WRISPADIGVKWDEMGEPEWDSPEMLAEGFLKEQRRIVSGYKGNPHVVMERWREANNPAH
VAISLIGEVTIYPYLSELIEIFHKKGMSTFVVTNGTFPEMIEKLNPLPTQLYMSLEAPDE
ETYKKTCRPKSNEAWEKMNETLELFPSLKTRKVLRLTLVNGLNMKNPKGYAKLIMKAQPD
YVEPKSFVFVGGARYNRGLKLDDMPKHEEIRKFARELAEETGYIISDEREDSRVVLLCRD
EKAERSRIIQKK
>I0Z6S6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Coccomyxa subellipsoidea (strain C-169)|TrEMBL
MKSLWRLLLSVKTNPVPIQDRVTQQDGSLRDTDHSPKTCQNNSGGAQEPDVVAAASQEAS
CCNGAGAEEKHSTANSSPWGDGCSSNACQCTAKTAASEPLVTAGISPSRGKVLFGSQKGT
SSTLAGQLAEQAAAQGVQLAVMDLGVFEVEQLWKEQLVIIVTSTYEDGTPPNNARWFCQW
LGASSTDCRVGADALKDTSFAVFGCGNSLYEANFNKVAMTVDEQLGGLGGQRLLPCGRGD
EDTGKMEQQFAAWSDALLQALREGPPSDEAAVEQTEGDARSDGYCTTDSDDDEAEQEEEV
ADLEDLAGPVSRNGVGDRAASTSGRAAADIGADAAAGPKEMLTPPLRAALGKQGYKLVGS
HSGVKLCRWTKSMLRGRGGCYKHAFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGRE
WRWKMDGPEEIVEGALSHHVRMINEFRGVPGVKADRLAEGMQVRHCALSLVGEPIMYPEI
NRLIALLHARRISSFLVTNAQFPDRIRQALLCLSLAPVTQLYVSVDAATRDELKAIDRPL
FKDFWQRFLDCLTTLRDKRQRTVYRLTLVKGWNMEAAQEYAQLVALGQPDFIEIKGVTYC
GSSSASSLTMHNVPYHQDICAFGQVLCDACNGEYGLSCEHAHSCCILLARKSRFLIEGRW
HTWIDYNKFQELAAGTSPFSSQDYMLPTPDWAVYGAPEAGFDPLEARVKKARNHPAKAEI
GGCT
>A0A514LC45|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Nitrosopumilus sp. SW|TrEMBL
MSCSGEVVEGEEQLIQIKPAISEQLKKAKYGVSDHSTVELCHWTKKSFKHEGSCYKHKFY
GISTHRCMEFSPAGMHCENRCVYCWRPMEFYDSLEMKPEQVAEPEEILTKLMAERKKLIN
GYYGDSRNDKERLDESLLPSHYAISLSGEPTMYPKLPELIKYLKSLEATKSIFLVTNGQE
PDMIQRLQDEDALPTQLYLSTNAADYESFLKINKPKYDDSWERWNRTLGMLKHLNTRTVL
RITLIRGYNDRMDMIPAFAKMFRESSPHFIEIKSYMHIGRSTNRLEHSNMLEMEEVKRFS
EKVAKQSKIFSVMDESFVSRISILQNNERFIDRWIPAYVNTS
>A0A497IG90|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Micrarchaeota archaeon|TrEMBL
MSSAYVQILRKQHYNVFGKREHSAAKLCTWTKKSIKNQGVCYKQKFYGIQSHRCLQMTPC
IYCQQRCVFCWRTYGPSPDVLPKEWDEPEHIYEESIKAQRKLLSGLGGIPEQIDIQKYEE
AMNPNQVAISLTGEPTLYPYLPELIGVYKRHGFSTFVVSNGLAPEMIDKIEPTNLYISLD
APNRELHKKIDRPLVDKAWDSIMQSLSMLKEKKNNTVVRITMVKGLNDVNPEQYAKILDE
TASTYVEVKAYMFIGGSRQRLSISNMPRHHEVKAFAQQILKHSSLYEYKDEQEASRVVLL
EKRDK
>A0A1E1JSL8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhynchosporium agropyri|TrEMBL
MSKDPSNFTTLRLTTCDNTEYDQAVTFKVYNCKVLEQPCDFAVWLTTLWCCGLCCPSKLL
LSGTVIEFQSYSQQHKLTGTPPISPSLPALKEKPLPAEKKPPAEKVPRRIVGGLKKGKSS
QEEIKPTAQKIQVLVFFSSLTGTTEKTAKVFTESLAQNTKKLGATTSATFLEPEILDLSY
IDYDEYFINPPKSDSGAQYFYLLLLPTYNIDTVLDNFLEHLQETHNDFRIDTAPLSPLLG
YSVFGFGDREGWPTEEEGFCSQAREVDKWMAKLTGRKRAFPLGMGDSKKDAADRLAEWKE
GVEDMLAHIAATGNLGEGVVGSGDAVESDVEDLDDDEDVLFDEQNVAIRKTKTKKKEALN
DLEDIGSTLNKTEAAEDDDDEDDDDDDEELELDFTTYSKKSVTKTAAAVIKEMVPKNSPT
YTALTKQGYSIVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKC
VFCWRHGTNPVGTTWRWKVDPPEMIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHC
ALSLVGEPIFYPHINEFTAMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRES
LRKIDRPLHRDFWERFNRCLDILKERRFEQRTVFRLTLVKGFNIEDEAEGYAALVAKGLP
CFVEVKGVTYCGTSSSAGAGLTMQNVPFYEEVCAFVEALNAALARRGLGYGIAAEHAHSC
CILLASERFRVEGKWHTRIDYEKFFKCLESGEEFRPEDYMGPETPEWATWGNGGFDPRDE
RVFRKGKNKVALKERQGEVMEI
>A0A2V2X554|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Trypanosoma cruzi|TrEMBL
MTESVSEALWWVLLGALIPLVTLTLTTLLDRWVSRRKKRQMEVARAQASKEGERTWMEPN
VHNSTGKTNGNGSTIHDAVRGSKGGVDVKKILIAYATQSNTACKLAHKLFSALSTALHES
RDEVQGGSSSCVCSEGPSSCCATSHTARHLPELKVLQLTEEGRQCGVEHLLESQAYGLII
LIASTYTDGTAPESSQVFANLLQDAYTDFRVPRDTLAKKKLAIFGLGDIAYGEKHFNRFA
KNVYMWCKGLGATFVVPPVYASEANTIPLFNMFTASLVKWVGRVTFTADGVTILKRQQKQ
LKEKEQLKLCNDVELKGHATYNSEEDEEDEEREEEDEENGRKKRNHNSEGDVEDVVTDDE
DEGEDANGQSGSVDHAVQASSSEPPELLYPRLRQNLQRQGYHLVGSHSGVKLCRWTKAML
RGRGGCYKHTFYNIVSHQCMEMTPSLACANKCVFCWRHHTNPVSRTFRWKVDPPQLLIAE
GIAGHQKMMKQMRGVPGVTSERLEEGMHVRHCALSLVGEPIMYPEINTFVDLLHERGISS
FMVTNAQFPEQLHALKPVTQLYLSIDAPTPEELKRVDRPLFEDYWERCLACVRELRRKPQ
RTVFRLTLVNQYNTENVAAYADLVRLGWPDFIEVKGVTYCGTSAASTLRMKENVPRHEEV
VRFCAALCEALASDTAPRDKRTWLGTEPETGPLQRDLNCDEKRTSVNNMENNNRRCNRKD
EEEGVGINFSGPYSIACEHEHSCCVLIALRRFLVNGVWHTWIDYEKFNALARSGRTEFTA
AEYAAPTPSWAVFRSNEKGFDPTQVRVHRKSGNTTVVTSSC
>A0A482YDP7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena hispanica|TrEMBL
MSDSAPSGADADEDGGPAQVSSPDYHSENHTAAQTCGWTANALRGEGKCYKNIFYGIESH
RCIQMTPVVRCNERCVFCWRDHNGHAYELDDVEWDDPEAVVDASINLQKKLLSGFGGNEE
VPREVFDQAMEPRHVAISLDGEPTLYPYLPELIEAFHDRDITTFLVSNGTRPEVLRECDP
TQLYVSVDAPERHTFDQVVGAMEDDAWENLLETMAVLADKDETRTVLRTTLVDGENMHHP
DWYAGFYQQADPDFIELKAYMHVGHSRGRLDRSSMPDHEDVIEFAESVADHMPEFDEVMG
VPASRVALLSKTSDTWVPKLKKDSEFWNRDPVTGE
>A0A8C2JFY6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
ILCKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRYAVFGLGNSVYV
GHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKAKFLNRLQALAK
GEKKACSGKCKSASCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSDAESSAEEEKSHGS
VIDMEDLGNVMNRMKKTKVKTKPCRSTVVTYRYKLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKIIQEAVENHKNM
IRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQNISSFLVTNAQF
PEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGEKQQRTVYRLTL
VKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHEEVIYFVQQLAN
LLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEESGGTKIFSAMDY
MAKTPIWAIFGARERGFDPSDTRFQRKNKTKNISGC
>A0A8C1PZP5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Cyprinus carpio|TrEMBL
FLSRFIHDVCSCTSKMICVFLVATYTDGQPTESAEWFCKWLEEASTDFRYGKTYLKGMRY
AVFGLGNSVYVGHYNTVSKNIDKWLWMLSAARIMTRGEGDCNVVKSRHGSVQADFQAWKT
KFLNRLQALAKGEKKACSGKCKKGSCKNKKKHKEEAEDSHSLAEKNNSEEELMESSSDAE
SSAEEEKSHGSVIDMEDLGNVMNRMKKAKVKTKPCSSTVLTYRYKLIGSHSGVKLCRWTK
SMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWSWKMDPAEKI
IQEAVENHKNMIRQFRGVPGVRPERFEEGLTVKHCALSLVGEPIMYPEINSFLRLLHQQN
ISSFLVTNAQFPEEIRSLVPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLRALGE
KQQRTVYRLTLVKAWNVDELKAYADLIALGQPDFIEVKGVTYCGESSASSLTMANVPWHE
EVIYFVQQLANLLPDYEIACEHEHSNCLLLAHHKFKVDGEWWTWIDYERFQELIQEYEES
GGTKIFSAMDYMAKTPIWAIFGARERGFDPSDTRFQRKNKTKDISGC
>A0A1E4U3E0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Pachysolen tannophilus NRRL Y-2460|TrEMBL
MGVSSFVLVGALFIYLVSGGRWTLVSLVVTVYFLAKNLEKRDGASSERHDNVSSGKIIAS
VAAAKVAKVAKVATAATAATTTVANVPNEVDFTLSFKPKSNLLSERIKAKRVPKIINAKG
KKPTKSLSPTLKSVGSNSWLNSNIIIFYTTLTGSSQRAAEKLYQKLSNDINLTNKPKLLN
LDDDVNDLDDYFVNVPADLPNLVYILVLPSYDTDSPIDYFLETLQETFNDFRVDKYPLKK
LAGFSVLGVGDSESWPERFCYQAKLADKWLGKLGGRRIFPLGTICMKTGGDNRIEEWINL
FAESLKDDTPITLNNNRNNDDGDDIEEIGSDNDNDNDNDNDSGSGESEGTLVDVEDMGKM
IRESSSDSSEVDIMERREIKEMVAKDSPTYKSLTKQGYTVVGSHSGVKICRWTKSALRGR
GSCYKFAFYGIKSHLCMETTPSLSCSNKCVFCWRHGTNPVGTSWRWQVDGPEVILKGALE
GHYKKIKQMRGVPGVVAERFNEAFTVKHCALSLVGEPIFYPYINEFVEMLHEKHISSFLV
CNAQHPEQLNALGKVTQLYVSIDASTRDSLKKVDRPLFKDYWERLLKCLEILKTTQAHQR
TVFRLTLVKGFNMTDVNEYADLVARGQPSLIEIKGATFCGSSSGNGNPLTMQNIPFYQEC
QQFVRNLNQELQKKGFSYDIACEHAHSCCILIAQTKFKINNKWHTHINYNKFFQLLESGD
KFNDLDYVSETPDWAYWESQEGGFNPEDTKYDRKTEKAKNKLAREQQQQADLI
>F4B4Q6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Acidianus hospitalis (strain W1)|TrEMBL
MHYFKLTIMVVSTLRIDTLSRIMEEMEKEKYHIIGNHSAYKKCHWTHEALTEGRYCYKGK
FYGIESHRCVQMTPTAAWCWFRCIHCWRLEPEDIGLEWDETKLPITDDPEYIAEKSIEEH
KRAVSGYLGRKGVDPNMAKEAMKPAHVAISLTGEPTLYDRLGELIHEYHKRGLTTFLVTS
GVRPDVLASLEEEPTQLFVSIQAPNERKHKLINRPIVANSWNLFLKTLEILPSFSSPTVI
RMTMIKGFNMSEEDAKDFAKLIEMAMPTYIEVKAYMHVGPSTLRLSRDAMPRHSEVREFA
KLMEKYTGYKIISEHVPSRIVLLSKLDKPIQIGNAWSDKWNWATKDTEDDIHGEYAEAEL
DSGNNQC
>A0A1V4ZYH6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanoregula sp. PtaU1.Bin051|TrEMBL
MPSGPCDALRRQGYQFFSSQSSAALKPCMWCKRALAGGDMCYKHQFYGIASHRCVQMTPT
LRCNQRCLFCWRSFEHEVTAEEECPPDVILTGIRRLQKKALAGYNAVLDNTVTDEKWQEA
LDPKHVAISLSGEPTLYSRLPELIDLFNANGYTTFLVSNGTNPDVLERCRAYQTYVSLDA
PDEETYRKVCRPLADTWELVNESLRLLGKCRSAVRITLVAGLNDVTPAKYAAILQESGAR
FVEVKGYMYLGYSRNRLQRKNMPEHDAVRAFAEKIAAACDYRVRDENRLSRVVCLEREG
>A0A177CRI4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Paraphaeosphaeria sporulosa|TrEMBL
MSLDRFLVLPDELLLIWHDHRVPLLLSAVSLAVLVHLAIYFRSRRHKISASPAPSSPIEK
KEIELRPEWLPENTTIVTPAVNVDNRAEDSVVSVPVVKAKKGPKTVKGKKVPKKRAPAAA
NFNHKTDKIQPLVFFQSLSGTTERYATQLTKVFTEWTAGCDQSISFLEPQIHDLSYIEFD
DFFLSPPKNDSSVKYFYIILLPTYNIDTVLDNFIENLQETHNDFRIDTAPLSGLLGYSVF
GLGDKEGWPTEEEGFCSQAREVDKWMARLTARKRAYPLGIGDVKSDVDTRLGEWRVGVQE
ALVELAEGRGLGEGVPGSGDPAESDEEDEDVAEDSESEGVSPKPRKAARVDDVEDLGGMV
KSDSADPIPVDFTTYKSRVSKPVSAPKEMVPVSSPTHAALTKQGYSIIGSHSGVKICRWT
KSALRGRGSCYKYSFYGIQSHLCMEATPSLSCSNKCVFCWRHGTNPVGTTWRWITDAPEL
IYDGITTAHYKKIKMMKGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINELLAIMHKN
RISTFLVCNAQHPAQLASLIPVTQLYVSIDASNKDSLRKIDRPLHRDFWERFCACLDILK
QRRFEQRTVFRLTLVKGFNMAEEARGYADLVERALPGFVEVKGVTYCGTSAAGSAGLTMQ
NVPFYEEVAAFVTLLAEELAKRNLSYGIAAEHAHSCCVLLADSTRFQKDGKWATRIDFER
FYELNEGLVEGTRTDADGKVVGWRPEDYVGQETPEWALWGNGGFDPRDVRVWRKGKGPKE
QAGKDAKVVEM
>A0A7L2DWJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Southern penduline-tit|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRIKRKKSHGNPSSPKG
TADKLENGCATPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVMSLNVPVEVINMEDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDKCLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFL
TRLQALCKGEKKPCSGKCKKGKCRSSGKHSQEGLDYEHGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHVKKAKLLLIEGVWNEEGAAGAGKKEEAERREMITPALRQALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKAARLQEALAVKHCALSLV
GEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRID
RPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGV
TYCGESSASSLTMANVPWHGEVVSFVQELAQLLPEYGIACEHEHSNCLLLAHSKFQVGGE
WRTWIDYGRFQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNK
ARDISGC
>A0A7L2DWJ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Anthoscopus minutus|TrEMBL
LDVSMDMWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVIQFTTTRIKRKKSHGNPSSPKG
TADKLENGCATPQAQEVHVAGVKIFYGSQTGTAKRFAKALAEAVMSLNVPVEVINMEDYD
PEDGLAEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGLRYAVF
GLGNSAYVDHYNTVGRRMDKCLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAWKTKFL
TRLQALCKGEKKPCSGKCKKGKCRSSGKHSQEGLDYEHGTSEHENTEAEELFETSSEEEA
GGTDSVIDVEDLGNIMGHVKKAKLLLIEGVWNEEGAAGAGKKEEAERREMITPALRQALT
KQGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKCVFCWR
HHTNPVGTEWRWKMDQPEVILQEAIEKHQNMIRQFKGVSGVKAARLQEALAVKHCALSLV
GEPIMYPHINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKESLRRID
RPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFIEVKGV
TYCGESSASSLTMANVPWHGEVVSFVQELAQLLPEYGIACEHEHSNCLLLAHSKFQVGGE
WRTWIDYGRFQELVREHERSGGSRTFTAAEYTARTPPWALFGARERGFDPLDVRFQRKNK
ARDISGC
>A0A8C2V2N2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Chinchilla lanigera|TrEMBL
MDSSLDVWTLCSPLLSLWINRFYIYLGFAFGISLWICFQIAIKKQLFIFKAKNSQDKSVP
KATQDLMPNGFISLQKKPIFVSGVKIFYGSQTGTAKGFAAILARAVTSLDLPVEVINLKE
YDPDDHLIEEVTSKSVCAFLVATYTDGRPPESAEWFCRWLEEAASDFRFGKTYLKGMRYS
VFGLGNSAYPSHFNRVGKSVDKWLWMLGARRVLARGEGDCDVVRSKHGSIEADFAAWKAK
FISRLQVLREGEDQSCGGRCKKGKCDSKPRGSQEPEPGSHLPDGSRPRDAKEEEPCESSS
EGELGPDDRRSLGSVVDVEDLGKIMNRTKTAKREKDHQEEKTRLLRSTGQSGKGERRAMI
TPALRDALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLAC
ANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAVENHQNMIKQFKGVPGVKAARFEEGMR
VKHCALSLVGEPIMYPQINRFLQLLHHRGISSFLVTNAQFPEEIRNLKPVTQLYVSVDAS
TKDSLKKIDRPLFKDFWQRFLDSLKALAAKRQRTVYRLTLVKSWNVDELQAYAELVSLGR
PDFIEVKGVTYCGESSASSLTMANVPWHEEVVRFVCELVDLIPDYEIACEHEHSNCLLIA
HKRFKIDGEWWTWIDYNRFQELVQEYEDSGGSKTFCAEDYVSRTPPWALFGASERGFDPK
DTRHQRKSRSKNVTGC
>A0A842QEE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Lokiarchaeota archaeon|TrEMBL
MTSEMPEELREKLNRQGYHLLGERGAFKACQWQQKSLLYGDYCYKQRFYGIESHRCLQMT
PVVDKCTQNCQFCWRVTPEDVNVNWDQIVVDESDVLAPVNLLDETKMANLRSLGGYNPEA
GADVSQQMYNEAREPKHVAISLAGEPTMYPFLSDFIEEIDRNGMTSFLVTNGTMPEVLQE
ITLPTQLYVTLAAPNEKTYRRLCRPSVGDGWKRLMESQELLQSLDCRSVNRLTMVAARNM
HHSRLYADLITTGEPDFVELKGYMHLGASRKRLNRRNSPSHKDVKAFAEKISALTGYYLL
DEQVESRVVLLSRRKQIEKI
>A0A1V9YLA3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Achlya hypogyna|TrEMBL
MVSIRAPQLALAAAGLALVLASIAYVVNKDRATTRSLPPKATQCCGGSTKTGCCSAPTSD
EFKPVTVRILYGTHTGTARGFAEMLQKKLFALNVAGYAFEPSVVDMKDYDQDNLEHEQVV
ISILSTWTHGVPPESAKLFCNWLQDMAQDFRVSKSWLKHVFVATYGLGNAEYDEHYCTAA
KQLSKHFNALGATRLVKRGDGDDNQDQTAHFEQWSDQLVASLCEQYGALSAPKDAKEWVS
QKEFRRQKRKEKAIAAGEHDEEVMITDEDRMNEIVLDDDDDETPAPKGDGVVDVEDLGVV
MKESEAAALNREMVTPLQRKALTKEGYKIIGTHSAVKLCRWTKHQLRGRGGCYKHTFYGI
TSYQCMETTPSLACANKCVFCWRHHKNPVGREWRWKTDDPVELVEGAISRHQTMIKEVKG
LPGLIQSRWEEAFTVKHCALSLVGEPIMYPHINAFCRELHARNISSFLVTNAQFPEKIAE
LEPITQLYVSVDAATKESLKAIDRPLFKDFWERFLSCLRQLKEKGQRTVYRMTLVKEHNM
KEIDNYVELIEIGQPDLIEIKAVTYCGKSDASDLTMKNVPYHEEVRAFCELLCAKLGGAY
GLATEHAHSNCVLLAKTQFKIDGHWHTWIDYDKFHALVQQFYKDGTPFSTMDYIAPTPHW
AVYDAPEAGFDPIETRFRRTKEGKVVEIEYTATDSGCG
>A0A843K610|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanothrix sp|TrEMBL
MLSQDNPSETLARQGYHLIGSAAVKPCLWLNRAMRGGDQCYKHHFYGISSHRCVQMTPTL
QCNHLCLHCWRPIDHPQPEKEPLEPAALLEGIIAGQMKFLSGYGGAKTTDPERLAEARQP
KHVAISLMGEPTLYPYLKELLDQIRRRGMTSFLVSNATRPEVLADLRPTQLYLSINAPDE
EMYRRVCRPAADLWPRVLQSLEELKDHRCRSVIRLTLARGLNMQRPKDYARLIEKAEPDF
VEAKAYMHLGRSRDRLTREAMPSHEEILEFAGAVGRALGYELEADVPLSRVALLGSGRVN
RLIDMESPY
>A0A4Q4YLW1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Monosporascus sp. 5C6A|TrEMBL
MPRIRESEDAVILFSLPHLEELKLHGIDGDYGNFPPEISLNSELKKHAHNLRRLAITTLQ
DFRRFLEIGFGPSHRLDCLVDLPVLLELEVELFALVGSRLNMRDTQLEKTLPVSLKKLVL
WEEWWADRADYAADGCVVMFAIVAILFAVLFAVWLYLLLGKRQKKGTGSPKLESGKSLLA
ELLAEEKVSLSTAKEPSSGPRRIKGELRKADGPKSAVHVEPQRRVQILVFFSSLTGSTER
TAKQFTATLEASLLDQISESDQAFLKPQLLDLTQIDYDEFFISPPKSAEGSRPVDYFYLI
LLPSYNIDTINDNLLEHLKETHNDFRIDKASLAGLLGYSVFGLGDQEGWPTEEEGFCFQA
KEVDKWMAKLTGRKRAYPLGMGDSKRDLKERLAEWTEGVTEVVRQSAKTGCLGDGVPGSG
DAVESDDEYVSGGDDDGEVVVDEPVQPKKTKKSTRDIDDVEDLGRIMKTSRADANDATSR
APIAVDFTTYSKTSKKPPQTVKEMVAKSSPTYAALTKQGYSIVGSHSGVKICRWTKSALR
GRGSCYKFSFYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDPPDLIFDGV
KAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLALLHGERISSF
LVCNAQHPEQLAALKAVTQLYVSIDASNRESLRRIDRPLHRDFWERFLRCLDILRERRFR
QRTVFRLTLVKGFNVEDEVEGYADLVERGLPCFVEVKGVTYCGTSSSGGKGGGLSMANVP
FYAEVTAFVEALDRRLRERGLGYGIAAEHAHSCCVLLASERFRVDGRWHTRIDYDRFFEL
LEERGPDGEWTPEEYMGEATPEWATWGNGGFDPRDERVDRKGRKIEA
>A0A0L7KEB8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium falciparum (isolate HB3)|TrEMBL
MGIVEEEFLLKNILGTHYNKKKYINDIINKNIYINNINGNMNYDDILPKKDYIEKKIQIN
ESYKNDDNVDHSNMDGNIIDKNNCVNNSLDIKDMNSLENEIIEYFKLRFDKYQVNKKKRK
EKISNYENMIPLYYNKNINYLEPYEENVKMFNSKFKNYVGCTIDNKNIGKIYFNLIDGNN
HDYYSFFDCTENYNLNVLFFFISTSSHGSFPNNSYKIDEIFTDMLNDFRIEKNYLKDIFF
SCIGFGNKEYGDKYFCTPIKKCEKYIHLLGAQKLYKTLKLCDTQDNDETILLWKCNIFKT
FSLSLFFYSFNYMKRWYMNKGIYDTLSYYCYFFSNYTNFNVNQTQEIKYYMHDQKHETEK
KKKKNNKIKKKKGDLSIYPMEQLEGCHCNKAYQENDLSIDQSNIDYNNNKCCNNEIYNTH
NNIYDNDKDDHQIFLSTIGNDEKDIVNEHKTKVDKTNGMMNEKREEVYIRGDIQGVEGCT
NCNCQSVNEYNDTSNTNDTNNTNIMNNTNNTNIMNNTNNTNIMNNTNNTNIMNNTNNTNI
MNYTNNIRTGENCVSESETSSNQSYPDDEDEQIEVEDLISGEKKDMLSSSQRNKLTKEGY
KIVGSHSAVKLCRWTKSQVRGRGGCYKHTFYGINSYQCMEATPSLACANKCVFCWRHHKN
PVGVKWRWNMDKAEIIVEEIIKKHKAMIKELKGIYGIIMERFEKAMNIKHCALSLVGEPI
MYPEINKLIDELHKRNISTFLVTNAQFPQELENLNTVTQLYLSIDAPNKEALKNIDRPLF
KDFWDRYIKCIKILKNRKERKVFRFTLVKEYNMMENEIDSYINLIQLGYPDFIEIKAVTY
CGSSQGYQLTMQNIPWHEEVYQFAWNLINKKKALSHIYEISCEHKHSCSILITKKIFKIN
NKWNTWIDYEKFHQLVKNKENFNALDYSVETPHWAIYGSQESGFSPCEKRVYTKGKYKNK
NQQS
>A0A0L0NGD2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Tolypocladium ophioglossoides (strain CBS 100239)|TrEMBL
MFTPSSSHFEPPKSHSLKSRDIDDSVHGGLTSPAKFSVEGTLKIDFATLHHREQTPVQAP
LMRAALGYRRLCSQDWLSGLGPGTAVADLVGLWHAHRTPLILCALAILVSIRIYLHLYEE
TEELIALPKVYQKHAPPTTSAQTARGSLDKKTVTKSNGPRRIKGGIARKPSREEKENVDL
TRPVKVLVFFSSVKTKTETFARDYMTRLGKATEQLAQETKREFLKPELHDLSEIDFEDFF
VSPPKSNDDAVFFYLFLLPSYNIDTINDTLLQHMEETHHDFRVDTASLAPLLGYSVFGFG
DGEGWPNEAEGFCFQAKELDKWMSKLTGRKRAYPIGMGDMKSDHAERFEEWAAGVHETIG
QAATTGSLGDGVRGSGDAIESDQEDIADEDDGEVVFEDDENDENETPRALDDLEDLGKMI
RTSGNDGNTGSQKAPLAIDFTTYGLSTKKKAQPQAPVVKEMVAKNSPTYAALTKQGYAIV
GSHSGVKICRWTKSALRGRGSCYKYSLYGINSHQCMETTPSLSCSNKCVFCWRHGTNPVG
TTWRWVVDPPEMIFEGVKEGHYKKIKMMRGVPGVRAERYAEALRIRHCALSLVGEPIFYP
HINEFLAMLHAERISSFLVCNAQHPDQLAALRAVTQLYVSIDASNRESLRKIDRPLHRDF
WERFQRCLDILREKRFRHRTVFRLTLVKGFNVEDEAEGYAQLVERGMPCFVEVKGVTYCG
TSTSSNAGLSMSNVPFYWEVCEFVKALERRLHAKGLKYGIAAEHAHSCCILLASERFKVD
GKWRTHIDYKRFFELLEERGPDGDWRPEDYMGEPTPEWALWGNGGFDPRDDRVDRKGRKI
ENVVVREQPPGEVW
>A0A0J9SDU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Plasmodium vivax India VII|TrEMBL
MVQGDEAKNRRNFFQTIFEQHAVRKRKKAKINLRILYGSEGSNSYKKAKGFLNELIPFFK
DIENICNEINSIVTEEGGSHHLLNGRTNELGHGDDRLVSYFKEYSKLLQRRNEQNVKRGK
KDSLHEEGVNTAYEPLQQFQEKEKKGSDKFANYLDCCLSSNVCTVSFDFVSGNEFNDYTF
FERTSEYDLNVLLLFVSTASHGSFPQNCYKFEQLLEDLFNDFRVEKDFLKNVFYTCIGFG
NKQYGSTHFCSPVKKCDKYLSYLGAQKLFKTLKFCDEENNEEVFLLWKCSLFKTISLGLL
FYCFNFPQLCSFVPYADRKIYSSLQHYCFFFCAKGDSRKGIDADIGVSSKTDSAPIEVPQ
EGGNHTHGVIQKGESPQAGDPHNGDEWEEAPTDAKNGEVEMVEKGALTYGVKKGEDANRS
ASLCSSGDELEDLIPDKPKDMLTCNQRNKLTKEGYKIIGSHSAVKLCRWTKSHLRGRGGC
YKHTFYGINSYQCMEATPSLACANKCVFCWRHHKNPVGTHWKWNKDDAEMIVHEALKKHK
SMIKELKGAHGVVKERFDEASHVRHCALSLVGEPIMYPDINKLIDELHSKNVSTFLVTNA
QFPNELQKLHKVTQLYLSIDAPSEEALKNIDRPLFKDFWDRYVRCIKILKKRKERTVFRF
TLVKEYNMMSEEIVSYTKLIEYGYPDFIEIKAVTYCGSSDGYQLTMKNIPWHEEVYQFAY
NLVHSNGYLSDSYEIACEHRHSCSILIAKKKFKINDKWHTWIDYDMFQWLVRQNKDFTAV
DYCAETPAWAVMGAEERGFNPCDERVYTKGKNKNKPPLAESASR
>A0A7K9WCM2|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rhipidura dahli|TrEMBL
LDVSMDTWSYFHTCLVSIWLHRFYIYSAVAFGISLWIVSQFTTTRTKRKVTEPVSTFFWE
DPKNLGGTKLGNGCAPPQAQEVHVAGVKIFYGSQTGTAKRFAKTLAEAVTSLNLPVEVIN
MGDCDPEDGLSEETSSRNICVFLVATYTEGQPPESAAWFCKWLEEAANDFRVGKSFLQGL
RYAVFGLGNSAYVDHYNTVGRRMDRWLWMLSASRIMTRAEGDCNVAQSKHGSIEADFEAW
KAKFLTRLQALCKGEKQPCSGKCKKGKCKSSGKRSKDSSDHEHGMSEHENTEAEELFETS
SEEEAGGTDSVVDVEDLGNIMGHMKKAKVLLLEGAHGVNHFRYQLVCLVDQFLQAKLNCL
MIFALFSGYKLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMEATPSLACANKC
VFCWRHHTNPVGTEWRWKMDQPEVILQEAMENHQNMIKQFRGVSGVKAARLEEALRVKHC
ALSLVGEPIMYPQINRFVRLLHQHGISTFLVTNAQFPEEIRRLEPVTQLYVSVDASTKES
LRKIDRPLFKDFWQRFLDSLKALAEKQQRTVYRLTLVKAWNVDELKAYADLISLGKPDFI
EVKGVTYCGESSASSLTMANVPWHGEVVGFVQELARLLPDYGIACEHEHSNCVLMAHSKF
QVDGEWRTWIDYGRFQELVREHEHSGGSRTFSATDYMARTPPWALFGARERGFDPLDVRF
QRKNKARDISGC
>M0AWK4|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Natrialba asiatica (strain ATCC 700177 / DSM 12278 / JCM 9576 / FERM P-10747 / NBRC 102637 / 172P1)|TrEMBL
MSDSADAGVEVGADADPDQGRERDRDDGDPGGGPAQVSSPNYHSENHTAAQTCGWTANAL
RGDGRCYKNIYYGIESHRCIQMTPVVKCNERCVFCWRDHQGHAYEMDEVEWDDPEAVVDA
SIELQKKLLSGFGGNDEVPREVFDEAMEPRHVAISLDGEPTLYPYLPELLEAFHDRDITT
FLVSNGTRPEVLRECDPTQLYVSVDAPERHTFDRVVKAVDDDAWDRLLETMAVLRGKDET
RTVLRTTLVKGENMHHPDWYAGFYQQADPDFIELKAYMHVGHSQGRLDRSSMPDHEGVLE
FADAVKSYLPAFSECKGVPSSRVALLSKTSDTWVPKLKKGSEFWARDPVTGTGD
>A0A7T8JTU6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Caligus rogercresseyi|TrEMBL
LKYCVFGLGNSAYGSEYYNATGRNLDKFFRQLNAETFIPLTLKEFMTWAQALGKQMKLNE
WGYESDESEEYSDEEDEVEEGDDLVDMEDLGVVMKKAKDSKSSSGLPKDMVTPSLRKSLT
KQGYKIIGTHSGVKICRWTKAMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWR
HHSNPVGTEWKWSMDPPDMILDGALENHYKMIKQMRGLAEGMDVQHCALSLVGEPIMYPE
INTFRISSFLVTNAQFPDAIKNMDPCTQLYVSIDASTKDSLKKIDRPLFRDFWERFIESL
KELAHKGQRTVYRMTLVKGFNVEELEDYAKLVALGRPDIIEIKGGTYCGTSKGKIIEDIS
>A0A831P684|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Archaeoglobus sp|TrEMBL
MMKDKVLSELKGYQIVGQHSAVKTCFWLKKSLKDKGVCYKQKFYGIESHRCLQMTPALMC
NQSCIYCWRPLELLGEVNNWDPPDYIVEESIKAQHRLLSGFHGTEGVNKKKLNEAYKPNQ
VAISLIGEPTLYPYLPDLIEEYKRRGFTTFLVTNGTRPRMLELSNPTQLYISLTGYDEES
HLLLNRPNRSNWNLILRSLEVMRESKSRTVIRLTLIKGYNMHSNALKRYSELIKLASPDY
IEAKAYMYLGYSRLRLRYENMPGHSDIVSFSKELEKLTGYRIVNESMVSRVVLLSR
>A0A0E3NDU1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanosarcina thermophila (strain ATCC 43570 / DSM 1825 / OCM 12 / VKM B-1830 / TM-1)|TrEMBL
MEEKKRNTGEDFPEVQEKNGGGESTSLPFDIPDFKTLLKKQGYALAGRHSAVKTCLWLRH
AMNGQGSCYKSKFYGVQSHRCLQMTPTLMCNQRCLFCWRPTEVPVPAPEEWDLPEKIVEE
SIACQRKLITGYGGSPNALKERWLEGNEPNNVAISLSGEPTLYPYLPELIEEYEKRGFTT
FLVTNGTVPDMFAKISPSQLYMSLDAPDLETYLKVCQPRSPALWEKINESLSIMKQKKSR
TVIRTTLVKGENMFKPEAYARLIEKASPDFVEVKAYMHLGFSRLRLDRSAMPTHEEVLEF
SKELAKHLGYKIADESEISRVVLLSKDGNKSPVRNLSFPD
>A6UQ85|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)|TrEMBL
MIPDEIYNVLRKQHYQIKGHSSVKLCGWVRKSFLDGNECYKSKFYGINTHRCIQSTPSVA
WCQQECMFCWRILPSDLNTKPYSLPEWKNPENVAEDILKMHRTILMGYKGILNRIGEEKF
NEAMTPKHIALSLSGEPTMYPYLAELIEIFHNLGMSTFLVSNGILTEIIEKVNPTQLYIS
LDAYDLESYKKICNGTEKDWENILNTLDILKNKKRSCIRTTVIRNINDDLLKFKELYSRS
NANFIEIKSYMNVGYSRKRLELSDMLKHEELLRMCENLEKNSSFEITNDSFESRVVLLSN
KDKKLNPKIDFGF
>A0A4V4H7U9|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Musa balbisiana|TrEMBL
MAKTPLAPPLSSSRLALVALLSATSVFFLWKSRRRLRVLLSPYSSMNPPKPSPRGKIIYA
SATGTSRSLAGRLSDYLRSHGLAFDLVDPRHYEPEDLPKEALFLIVASTWEEGRPPPDAQ
FLGRWLAESAADFRVGSLLLAKCRFAVFGVGSKSYGDSFNAAAKDFSKWMRALGASEMAP
VWEGDVDSGDVDEVFELWSRRIVALLKGEDLKKESGHSVSMVESVGFDESDEEVEEEVLE
PVVVDMEDIAGKAPSRRSSLALTNGWENGVRDMVTPVIRVNLEKQGYKIIGSHSGVKLCR
WTKSQLRGRGGCYKHSFYGIESHRCMEATPSLACANKCVFCWRHHTNPVGKSWRWKMDNP
LEIVDVAIDEHTKMIKQMKGVPGVKPERLSEGLSPRHCALSLVGEPIMYPEINTLVDELH
RRHISTFLVTNAQFPDRIKMLKPITQLYVSVDAATKDSLKAIDRPLFGDFWERFLDSLKA
LRDKEQRTVYRLTLVKGWNAEDVEAYANLLGIGKPDLVEIKGVTYCGSSATSKLTMDNVP
WHSDVKAFSEALAMKSSGEYEVACEHAHSCCVLLAKVDKFKINGEWYTWIDYERFHELVA
SGKSFKTEDYMARTPSWAVYGAEEGGFDPDQSRYRKERRHGAASVQT
>A0A8H4FXI3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Aspergillus lentulus|TrEMBL
MAEHSTAEGLTKRDPPTNIMLTDSSFIGLLAFWHSYRLLFLVALSTVFVGLRFYRKLQSR
TKTTASSSVPPSPRSQSPEKTEKGVSLESSNKATTQKAERQPAVANGSARTTSGPKRVTG
KKPLKVAGRRGLTEDAEPLAFIQPIIFYASLTGNTERYAKILLEELRAAAQKRADLQDRE
RGLLPPQIHDLSYVDLDDYFTSAPKPPSNSPGTGYVYCLLIPTYNIDSILNTFLDHLNET
HNDFRIDTGPLSSLAGYSVFGFGDKEGWPTEEEGFCSQAKELDKWMAKLTRRKRAYPLGF
GDVKSDAESSLKEWSQGLQDVLFDILKNGGLGEGVPGSGDPVESDEELDDEDADKDNTQN
VMDLEDIKFGGDQNAAGSPIPVDFTTTGKSSSGQSTEKEMVPKTSPTYAALTKQGYTIVG
SHSGVKICRWTKSALRGRGSCYKYSFYGIRSHLCMEATPSLSCSNKCVFCWRHGTNPVGT
TWRWKVDSPELIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPH
INEFLDMLHAEHISSFLVCNAQHPDQLEALRRVTQLYVSIDASNRESLRKIDRPLHRDFW
ERFQRCLDILREKRHVQRTVFRLTLVKGFNIDDEVIGYANLVEKALPCFVEIKGVTFCGT
STTAGVGLTMQNVPFYEEVAQFVTALNAELQRRGLKYGIAAEHAHSCCVLIASERFYVKG
KWHTRIDYDRFFELLEKEKADGTSFTPEDYMRETEDWALWGNGGFDPNDQRVYTKGKKKH
MQITAEP
>A0A7J6L3Z8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Perkinsus olseni|TrEMBL
MLAGGFYRALLSKHYSGPSRTVKVVYSSRTGTSKAAAGRLKDTLESDKIRVILLPIEQYS
YEELCEESYLVLLLSTDTDGTPLPGAKDFTEQLRDAVYDFRVDKNVLEKCKVAVIGFGSE
EYPAKHYCKVAKNCDDWLAKLGAQRVSPLLCISDTRDVEKQVSRCIDLIKKAYARLDAEP
TDQRTADLEDDVESVGSEESTSDTEDGDVEDASGACGGNDKEMVTKKHRAALTREGYRLV
GSHSAVKLCRWTKHQVRGRGGCYKHSFYGIESHQCMEATASLACANKCVFCWRHHRNPVG
RSWTWAQDPPEEIVNGWLGNHAGMVKELKGVPGVTPERFEQAKRVRHCALSLVGEPIIYP
QINTALDLLHQNGISTFMVTNGQFPEAIRSLIPVTQLYVSVDASNAEDMKAIDRPLFEDF
WDRFIDSLTALKHKKQRTVYRMTLVKGYNISTAAEYAELLHLGNPHFLEIKAVTFCGKGD
GSAQMTMENVPWFEEVVEFAQMIIESSPWVEERYEIACTHRHSCTVLIAQKSFKVDGVWH
TWIDYDKFTQLALKYSKTGKPFAVEEYWAPTPAWAVYGAEEEGFDPEMKRHYRNGKTPEL
GKQIRAKQLREEQERSSKCGDGKECCGGGC
>A0A2I0QHX5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Altiarchaeales archaeon HGW-Altiarchaeales-2|TrEMBL
MAKINPANRKIFERQHYSLVGNHSAVEVCSWTKKSLLNKGVCYKEKFYGVKSHRCIQMTP
ATAWCDFACLHCWRAHEYSQGTNMTGNLDDPKTIIDSSIKAQQKQLSGFKGNEKVNLKKW
QEAQDPFSFAISLNGEPTLYKKLPEFLKELKNRKIISFLVTNGSKPQMIKKLYDENSLPD
QIYISLIARDEEMHKKLNCPLIKNSWAKLLRTLKFFPKLKEKCRTVIRITLIKDKNDDAP
EKFAEIIKLAHPDFVEVKSYMFLGYSRKRLKKENQCSHKEVRAFSKKLAKLTGLKLLDDA
PNSKVVLLGKEKLRRFDNL
>A0A8C6WN04|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Neogobius melanostomus|TrEMBL
FSHGPVLSYITSIWHNRLFLYSAAALIFGIWFSVKVLQKKSVPSATNPLPQPVKSSDSAK
DTVAHVSGVKIFFGSQTGTAKGFAKELLDEVEASGFPCEIIDMKDYDPDDQLADEGTNKT
VCVFLLATYTDGQPTENAEWFCKWLEEASTDFRYGKTYLKGLKYAVFGLGNSVYTGHYNT
VGKNVDKWLWMLSAARIMTRGEGDCNVVNSKHGNIQADFKAWKMKFMNRLKKLAKGDKKS
CNGKCKSGGSCKNKTKHEHGHEERSEHVIQTVNAEEDLFESSSDEEESGLQDEKKGPVVD
MEDLGIIMNGVKKAKVKLYTNLLYNILIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIES
HRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDPAEKILQDSLEKHQNMIREFKGVP
GVKPERYEEGLAVKHCALSLVGEPIMYPEINVFLRLLHSNRISSFLVTNAQFPREIRNLV
PVTQLYVSVDASTKDTLKKIDRPLFKDFWPRFLDCLKALGEKKQRTVYRLTLVKAWNVEE
MLAYADLIAMGQPDFIEVKGVTYCGDSTASSLTMANVPWHQEVVAFVQQLADMLPQYEIA
CEHEHSNCLLIAHTKFNIDGEWWTWIDYERFQELVQAYEDSGGEQTFSSLDYMAKTPTWA
LFGAEEQGFDPTDTRFQRRNKAKNISGC
>A0A7J4MHD7|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Candidatus Poseidoniaceae archaeon|TrEMBL
MDPLLKAKLQKQRYHIVGEHGGVKVCHWTKESLLRDRQCYKGRFYGIASHNCMQMSPVVD
QCNLACSYCWREPHMDSLELTDQDPLEMLYDSVKAQRRLISGFGGNPKVPKEKFLDAQNP
KHVAISLNGEPTLYSRLSEYMELCHSHGMTTMLVTNGTLPKVIEKLDTLPTQLYVSVDAP
NKEVFDEICRPKWNAAAWDKFEQTIDLLPSLDTRIVCRHTLIKGRNMNPEHIPQYAALDN
RADPDWIECKGYVHVGNSRENLTAENMPFHEDILDFSRSLAPLTDRKLLDDSPPSRVALV
GKEIVPIPIPEATMYFPDDLGIAESVKHLKIVQ
>A0A5N7BY96|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Petromyces alliaceus|TrEMBL
MAEVSFIEGLLTFWHSYRLPILIAVTSVAIVLRVYQKSQPKSKAVSASSIPPSPRSQSPD
KFEKVCASNSEKLVVTEKSVPNSAVGNESAPKVASGPKRVSGKKPLKVAGRGRGSDQGPP
VSFIQPIIFFASLTGTTERYAQVLLEDLRAAAKERADPENRDRGLLPPQIHDLSYIDFDD
YFTTAPKPPSTSPGTRYVYCLLIPTYNIDTVLNTFLGHLDETHHDFRIDTSSLSTLAGYS
VFGFGDKEGWPTEEEGFCSQAKELDRWMAKLTGKKRAYPLGFGDVKNDAESALKEWSRGL
QEILLDILNNGGLGEGVPGSGDPLESDEEDLDDEENDGKRSKRRNGQDVVDLEDIKMGSS
DGQAGSGPVPVDFTTTGNSVAPSQSTEKEMVPKTSPTYAALTKQGYTIVGSHSGVKICRW
TKSALRGRGSCYKFSFYGIRSHLCMEATPSLSCSNKCIFCWRHGTNPVGTTWRWKVDSPD
LIFQGVKEGHYKKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLDMLHN
EHISSFLVCNAQHPDQLETLHRVTQLYVSIDASNRESLRKIDRPLHRDFWERFQRCLDIL
REKRHFQRTVFRLTLVKGFNVDDEVIGYANLVEKALPCLIEIKGVTYCGTSTSAGAGLTM
QNVPFYEEIQEFVLALDKELQGRGLDYGIAAEHAHSCCVLLASKRFYVNGKWYSRIDYDR
FFELLEKEKADGTPFRPEDYMKETEEWALWGNGGFDPNDERVYRKGKKKALQAPTE
>A0A1E5WAJ1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Dichanthelium oligosanthes|TrEMBL
MPPFPTATTAPASTTSHLALLVLLSSSSLFFLYKSIRLRRKPSRAIGPAHPTTPTLLYAS
ATGTSKTLAARLSARLTADAGIPVRATDAAAFDPDDLPSVPLLILVVPTHDGGAPPPSAA
FLARWLEESAADFRAGALLLSGLRFAVFGVGSRAYGETFNATARSFSRWLRALGAVEVVP
LGEGDVDGGDLEKVFEEWSGKVLKVVKGEELNEGVEGESDGFDELELEDEEFDDGDEEEA
VSGEIDMEDIAGKAPARRQNGKVEGGLANGGENGVKEMVTPIIRTSLEKQLGSVLYFYYI
YSIPIHILCVLQGYKILGSHSGVKICRWTKSQLRGRGGCYKHSFYGIESHRCMEATPSLA
CANKCVFCWRHHTNPVGKSWKWKMDDPLDIVNAAIDQHTKMVKQMKGVPGVKPEKLEEGL
SPRHCALSLVGEPIMYPEINALVDELHRRHISTFLVTNAQFPEKIKTLKPITQLYVSVDA
ATKESLKAVDRPLFSDFWERFLDSLKSLHEKDQRTVYRLTLVKGWNAEEIDAYAKLLDLG
QPDFIEIKGVTYCGSSATSKLTMENVPWHSDVKEFSEVLASKSGGVYEVACEHAHSCCVL
LAKVDKFKINGKWHTWIDYDRFHELVTSGKPFKSQHYMAETPSWAVYGAEEGGFDPDQSR
FKKERRHGTAALKG
>A0A662LVP0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MKKTLIDRLKKQQYGLVGSHSGVKLCHWMKQSLLHKRNCYKQDFYGIQSHRCLQMTPTVN
HCNHNCLFCWRYQGFTEHVIEKPDDPSFILEQSIKEQQRLITGFKGDERCDLKRWEEANK
PNMVACSLSGEPTLYPRLGEFFELCHKKGMTTFLVSNGTNPEVLKEMDPLPDQLYISLIA
PTKETYKKLCVPYITNGWEKIQETLELLPSLDTRTVIRQTLIKDWNFNHKYIENYAKFIK
KAEPLFVEPKGYVFVGSSRQRMNLSNMPSHQEIKEFGLKLSNEIGYEFINEKKDSRVVLL
CKVKKPKRINK
>A0A497HAC5|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MNEELRKLLEKQHYAIVGNHSGVKLCHWLKQSLLYNRVCYKQTFYGIESHRCLQMTPALT
QCTHNCLFCWRHQGFTEKTFKQVDDPEFILEESIKAQRRLITGFKGDPRCDQRNWEEANN
PNMVACSLTGEPTLYPRLGEFFELSHKRGMTTFLVTNGTTPEVLSNLDPLPTQLYVSIVA
PNKEVYKKLCAPLISNGWEKIMQTLELLPSLDTRTVIRHTLVKNWNMDLKYIPEYAKLDE
IASPMFIESKGYVFVGASRDRMTINNMPSHEDIMEFSRKLSDTMGYNLAMEKEDSRVSLL
IRDSSINPKFNR
>A0A5A7RXE0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmata archaeon|TrEMBL
MQGIREIFESQGYAIVGKHSAVKLCHWLRKSLLENRACYKHTFYGIESHRCLQMSPAAFH
CTQKCLYCWRFQGFTLKKIAEEIDEPKYILMKSIEEQRRLLTGYKGDDRVNLEKWQEAMN
PKHVACSLTGEPTLYPYLSQFFEECHKMGMTTFLVTNGTNPKALEKMDCLPSQIYVTVAA
PNEEIYKKLCCPLIPNGWKKINETLELLPSLNTRTVIRHTLVREWNLGWEEEYAKLDEKA
EPWFIEPKGYMFVGYSRQRMKLTNMPSHEEVKKFGETLASMLGYKVEAEREDSRVVLLGR
GKERKI
>A0A7C1VVF3|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MKDELREILKKQHYAIVGNHSGVKLCHWMRQSLLFGRECYKQTFYGIESHRCLQMTPTIN
QCTQNCLFCWRYQGFTELKIENPDDPLFILEESIRAQRKLITGFKGDPRCDQKKWREAND
PKHVACSLTGEPTLYPRLGEFFEACHKRGMTTFLVTNGTNPEALEKLDPLPTQLYVSVVA
PNKEVYKRLCRPNIPDGWEKLQKTLEILPSLETRIVIRHTLVDEWNNKDKYIKEYVKLDE
KASPLFIEPKAFVFVGYSRKRLTIANMPSHAKVKIFGERLAEELGYFFADEKPDSRVVLL
SKNKKVERIDKQS
>M0C848|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Haloterrigena salina JCM 13891|TrEMBL
MSDSADTGVEGGSDTDAEHDESEDGGAMQVSSPDYHSENHTAAQTCGWTANAVRGEGKCY
KYIYYGIESHRCIQMTPVVRCNERCVFCWRDHQGHTYEMDDVEWDDPEAVVDASIRLQKK
LLSGFGGNDEVPREVFEQAMEPRHVAISLDGEPTLYPYLPELIEAFRDRDITTFLVSNGT
RPEVLRECDPTQLYVSVDAPERHTFDQVVGATEEDAWERLLETMDVLAEKDETRTVLRTT
LVKGENMHHPDWYAGFYQQADPDFVELKAYMHVGHSQGRLDRSAMPDHEEVMAFADEVKA
YMPEFTESRGVPESRVALLAKQKDTWVPKLKKGSEFWERDPVVGD
>A0A7J2SQ27|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Thermoplasmatales archaeon|TrEMBL
MQEELKKILKKQHYAIVGAHSGVKLCHWMRQSLLFGRECYKQTFYGIESHRCLQMTPAIN
HCTQNCLFCWRYQGFTEQEIKNPDNPVFILEGSIKAQRRLITGFKGDERCDQRKWREANN
PKHVACSLTGEPTLYPRLGEFFEACHKRGMTTFLVTNGTNPEALENLDPLPMQLYVSVVA
PNKDVYKRLCRPAIPDGWERLQKTLELLPSLDTRTVIRHTLVAGLNDDERYIKEYARLDE
KASPFFIEPKAFVFVGYSRRRLTIANMPTHTQVKSFGKRLAEETGYFLVDEKPDSRVVLL
SKTKKVERLGKQS
>A0A2S7P7L8|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Rutstroemia sp. NJR-2017a WRK4|TrEMBL
MADETLSFRPFWAFESSDIVALWHLYRIPIILTTATILIIVRITLRPRALREKISASPLP
ASPALSAVKVKEKIAPAEFDEKKSSGSKAPRRIVGGVKKRKSSDENTNSKDQKIQVLVFF
SSLTGTTEKTAQVFTESLKQNLLNANAEEESSKYTEPQLLDLSYIDYDDYFITPPKGYTE
TTYFYLVLIPSYNIDTVLDNFLEHLQETHNDFRIDTAPLSSLLGYSVFGFGDREGWPTEE
EGFCSQARDVDKWLAKLTGRKRAFPLGMGDTKTDAKDRLKEWKEGVEDVLSHIARTGNLG
EGVVGSGDAVESDVEDLEEDDDGEVLFDEQNVASRKAKTQKKDTLNDLEDIGGGLNNTES
ADKEMTEEEAADLEVDFTTYSLKKAKTKAAPAVVKEMVPKSSPTYTALTKQGYSIVGSHS
GVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWR
WQVDPPDMIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPYINE
FTSMLHKEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNRESLRKIDRPLHRDFWERF
QRCLDILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEVKGVTYCGTSSS
AGAGLTMQNVPFYEEVCAFVEALTAALQKRGLKYGIAAEHAHSCCILIASERFRIEGKWH
TRIDYEKFFQCLESGEKFGPEDYVGPETPEWATWGKGGFDPRDERVHRKGKNKVPLTESQ
GGVKAELVEI
>A0A6B0T5J6|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Halovenus carboxidivorans|TrEMBL
MSDSEGGPKQVDNPSYHSDDHTAVQTCGWTKNALRGEGKCYKNIFYGIESHRCVQMTPVV
KCNERCVFCWRDHAGHAYELGDVEWDDPAAVADASIELQRKLLSGFGGNEEVPRERFDEA
MEPRHVAISLDGEPTLYPYLDELIEEFHDRDITTFLVSNGTRPEVLADCDPTQLYVSVDA
PDRQTFESTVNAVEDDAWERLIETLDVLSEKDETRTVIRTTLVDGHNMHHPEWYATMCER
ARADFVELKAYMHVGHSRGRLDRDSMPDHEDVVAFAEEMRQYLPHDELKQVPASRVAMLA
LDDDTWVPKLKKTSEFWARDPLAE
>A0A6I8RVC1|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|Xenopus tropicalis|TrEMBL
MTQTLILGILPQAAFVAAQQVDTDMSTNAWDFAYTHLMFLWLNRFYIYSCAAIGITVWFC
SHFITARKKQQNENVHNGSLPLKTKTLKSYNSPSIKEQDVYVAGVKIFYGSQTGTAKGFA
HMLDGEITLLGLPVEIINMKEYDPDDNLIEEATSKNVCVFLVATYTDGQPPESAEWFCKW
LEEASNDFRFGKTYLKGMRYAVFGLGNSVYSTHYNTVGKNIDKWLWMLSASRVMTRAEGD
CNVVKSKHGSIESDFEAWKAKFLSRLKALISGEKKPCSGKCKKGKCKSKMKSSTDAVEEE
AKHSEHEETEEETFETTSDSEPEEHGEPGSGLIDMEDLGKAMSIMKKAKREQDTNEEARN
RGKSLQSDEAKEKEEPREMITPALQEALTKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYK
HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILEEAILNHQNM
IKQFKGLEMSEAAAVKSCKHAGVPGVKPERYEEGLVVKHCALSLVGEPIMYPEINKFLRL
LHNQHISSFLVTNAQFPEEIRSLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSL
KALAEKQQRTVYRLTLVKAWNVEELKAYADLVAVGRPDFIEVKGVTYCGESSASNLTMAN
VPWHDEVVRFVEELADLLPDYEVACEHEHSNCMLIAHEKFKINGDWWTWIDYERFQELIR
AFDESKGSQKFTAMDYVAKTPEWALFGSRERGFDPLDKRFQRKNKTKDISGC
>A0A1V1STZ0|tRNA 4-demethylwyosine synthase (AdoMet-dependent)|EC 4.1.3.44|fungal sp. No.14919|TrEMBL
MDRGGSQSSRDFLEFWHIHREVILVVAICLSSTVWILYSTLPTKRVVKKPPLRPGATARL
APTKPVTLPTEKSEAPLEALSQDVAAPGPRRIKGELRKPEATRKSSDSDSSRRTQVLIFY
SSLTTTTGKIASDFAQNLSASLEGDAKHKDNFFGPIVLDLAEIDYDEYLISPPKPADSAI
PVDYFYLFLIPSYNIDTINDNLIEHLQETHHDFRIDTAPLSGLLGYSVFGLGDREGWPTE
EDGFCFQAKEVDRWMAKLTGRKRAYPLGIADKKLDLTDRLAEWTEGVTDVLKLAATTGSL
GEGVPGSGDADESDFEYASGNDDDEVMVEESAPKKKKNTKTKTNIDDVEDLGRIMKSNQA
NSNDSKGPTPIAVDFTTYSKSNAKKVAAQTVKEMVPKSSPTYTSLTKQGYSIVGSHSGVK
ICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVV
DPPEMIFDGVKAGHYQKIKMMRGVPGVRAERFAEAMRIRHCALSLVGEPIFYPHINEFLG
MLHAERISSFLVCNAQHPDQLAALKAVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRC
LDILREKRFKHRTVFRLTLVKGFNVDDEVEGYADLVEHGLPCFVEIKGVTYCGTSTSAGA
GLSMANVPFYAEVTEFVTALNKKLNERGLDYGIAAEHAHSCCVLIASGRFRVDGKWHTRI
DYTRFFELLEEHGADGDWKPEDYMGPETPEWATWGNGGFDPRDERVDRKGRKIEAS