Sequence of C1S_HUMAN
EC Number:3.4.21.42
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Cleavage of Arg-/-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-/-Lys bond in complement component C2 to form C2a and C2b: the "classical" pathway C3 convertase
Other sequences found for EC No. 3.4.21.42
General information:
Sequence
0 MWCIVLFSLL AWVYAEPTMY GEILSPNYPQ AYPSEVEKSW DIEVPEGYGI HLYFTHLDIE
60 LSENCAYDSV QIISGDTEEG RLCGQRSSNN PHSPIVEEFQ VPYNKLQVIF KSDFSNEERF
120 TGFAAYYVAT DINECTDFVD VPCSHFCNNF IGGYFCSCPP EYFLHDDMKN CGVNCSGDVF
180 TALIGEIASP NYPKPYPENS RCEYQIRLEK GFQVVVTLRR EDFDVEAADS AGNCLDSLVF
240 VAGDRQFGPY CGHGFPGPLN IETKSNALDI IFQTDLTGQK KGWKLRYHGD PMPCPKEDTP
300 NSVWEPAKAK YVFRDVVQIT CLDGFEVVEG RVGATSFYST CQSNGKWSNS KLKCQPVDCG
360 IPESIENGKV EDPESTLFGS VIRYTCEEPY YYMENGGGGE YHCAGNGSWV NEVLGPELPK
420 CVPVCGVPRE PFEEKQRIIG GSDADIKNFP WQVFFDNPWA GGALINEYWV LTAAHVVEGN
480 REPTMYVGST SVQTSRLAKS KMLTPEHVFI HPGWKLLEVP EGRTNFDNDI ALVRLKDPVK
540 MGPTVSPICL PGTSSDYNLM DGDLGLISGW GRTEKRDRAV RLKAARLPVA PLRKCKEVKV
600 EKPTADAEAY VFTPNMICAG GEKGMDSCKG DSGGAFAVQD PNDKTKFYAA GLVSWGPQCG
660 TYGLYTRVKN YVDWIMKTMQ ENSTPRED
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
12113
McKinnon C.M.,Carter P.E.,Smyth S.J.,Dunbar B.,Fothergill J.E.
Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence.
Eur. J. Biochem.
169
547-553
1987
12114
Tosi M.,Duponchel C.,Meo T.,Julier C.
Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.
Biochemistry
26
8516-8524
1987
12115
Kusumoto H.,Hirosawa S.,Salier J.-P.,Hagen F.S.,Kurachi K.
Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.
Proc. Natl. Acad. Sci. U.S.A.
85
7307-7311
1988
12117
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
12118
Endo Y.,Takahashi M.,Nakao M.,Saiga H.,Sekine H.,Matsushita M.,Nonaka M.,Fujita T.
Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates.
J. Immunol.
161
4924-4930
1998
12119
Tosi M.,Duponchel C.,Meo T.,Couture-Tosi E.
Complement genes C1r and C1s feature an intronless serine protease domain closely related to haptoglobin.
J. Mol. Biol.
208
709-714
1989
12120
Spycher S.E.,Nick H.,Rickli E.E.
Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation.
Eur. J. Biochem.
156
49-57
1986
12121
Carter P.E.,Dunbar B.,Fothergill J.E.
The serine proteinase chain of human complement component C1s. Cyanogen bromide cleavage and N-terminal sequences of the fragments.
Biochem. J.
215
565-571
1983
12122
Thielens N.M.,van Dorsselaer A.,Gagnon J.,Arlaud G.J.
Chemical and functional characterization of a fragment of C1-s containing the epidermal growth factor homology region.
Biochemistry
29
3570-3578
1990
12123
Illy C.,Thielens N.M.,Gagnon J.,Arlaud G.J.
Effect of lactoperoxidase-catalyzed iodination on the Ca(2+)-dependent interactions of human C1s. Location of the iodination sites.
Biochemistry
30
7135-7141
1991
12124
Hess D.,Schaller J.,Rickli E.E.
Identification of the disulfide bonds of human complement C1s.
Biochemistry
30
2827-2833
1991
12125
Rossi V.,Gaboriaud C.,Lacroix M.,Ulrich J.,Fontecilla-Camps J.-C.,Gagnon J.,Arlaud G.J.
Structure of the catalytic region of human complement protease C1s: study by chemical cross-linking and three-dimensional homology modeling.
Biochemistry
34
7311-7321
1995
12126
Rossi V.,Cseh S.,Bally I.,Thielens N.M.,Jensenius J.C.,Arlaud G.J.
Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2.
J. Biol. Chem.
276
40880-40887
2001
12127
Dragon-Durey M.-A.,Quartier P.,Fremeaux-Bacchi V.,Blouin J.,de Barace C.,Prieur A.-M.,Weiss L.,Fridman W.-H.
Molecular basis of a selective C1s deficiency associated with early onset multiple autoimmune diseases.
J. Immunol.
166
7612-7616
2001
12128
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
12129
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
12130
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
12131
Kapferer-Seebacher I.,Pepin M.,Werner R.,Aitman T.J.,Nordgren A.,Stoiber H.,Thielens N.,Gaboriaud C.,Amberger A.,Schossig A.,Gruber R.,Giunta C.,Bamshad M.,Bjoerck E.,Chen C.,Chitayat D.,Dorschner M.,Schmitt-Egenolf M.,Hale C.J.,Hanna D.,Hennies H.C.,Heiss-Kisielewsky I.,Lindstrand A.,Lundberg P.,Mitchell A.L.,Nickerson D.A.,Reinstein E.,Rohrbach M.,Romani N.,Schmuth M.,Silver R.,Taylan F.,Vandersteen A.,Vandrovcova J.,Weerakkody R.,Yang M.,Pope F.M.,Byers P.H.,Zschocke J.
Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.
Am. J. Hum. Genet.
99
1005-1014
2016
12132
Gaboriaud C.,Rossi V.,Bally I.,Arlaud G.J.,Fontecilla-Camps J.-C.
Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle.
EMBO J.
19
1755-1765
2000
12133
Gregory L.A.,Thielens N.M.,Arlaud G.J.,Fontecilla-Camps J.-C.,Gaboriaud C.
X-ray structure of the Ca2+-binding interaction domain of C1s. Insights into the assembly of the C1 complex of complement.
J. Biol. Chem.
278
32157-32164
2003
